AustralieFrV1, PubMed, Checkpoint, bibRecord, 001897

Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.

Identifieur interne : 001897 ( PubMed/Checkpoint ); précédent : 001896; suivant : 001898

Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.

Auteurs : Charlotte Fribbens [États-Unis] ; Ben O'Leary [États-Unis] ; Lucy Kilburn [États-Unis] ; Sarah Hrebien [États-Unis] ; Isaac Garcia-Murillas [États-Unis] ; Matthew Beaney [États-Unis] ; Massimo Cristofanilli [États-Unis] ; Fabrice Andre [États-Unis] ; Sherene Loi [États-Unis] ; Sibylle Loibl [États-Unis] ; John Jiang [États-Unis] ; Cynthia Huang Bartlett [États-Unis] ; Maria Koehler [États-Unis] ; Mitch Dowsett [États-Unis] ; Judith M. Bliss [États-Unis] ; Stephen R D. Johnston [États-Unis] ; Nicholas C. Turner [États-Unis]

Source :

Journal of clinical oncology : official journal of the American Society of Clinical Oncology [ 1527-7755 ] ; 2016.

RBID : pubmed:27269946

Descripteurs français

KwdFr :
- ADN tumoral (génétique), ADN tumoral (sang), Adulte d'âge moyen, Androstadiènes (usage thérapeutique), Femelle, Humains, Nitriles (administration et posologie), Oestradiol (administration et posologie), Oestradiol (analogues et dérivés), Oestradiol (usage thérapeutique), Pipérazines (administration et posologie), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Pyridines (administration et posologie), Récepteur alpha des oestrogènes (génétique), Récepteur alpha des oestrogènes (sang), Sujet âgé, Survie sans rechute, Triazoles (administration et posologie), Tumeurs du sein (génétique), Tumeurs du sein (sang), Tumeurs du sein (traitement médicamenteux), Études prospectives, Études rétrospectives.
MESH :
- administration et posologie : Nitriles, Oestradiol, Pipérazines, Pyridines, Triazoles.
- analogues et dérivés : Oestradiol.
- génétique : ADN tumoral, Récepteur alpha des oestrogènes, Tumeurs du sein.
- sang : ADN tumoral, Récepteur alpha des oestrogènes, Tumeurs du sein.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Androstadiènes, Oestradiol, Protocoles de polychimiothérapie antinéoplasique.
- Adulte d'âge moyen, Femelle, Humains, Sujet âgé, Survie sans rechute, Études prospectives, Études rétrospectives.

English descriptors

KwdEn :
- Aged, Androstadienes (therapeutic use), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Breast Neoplasms (blood), Breast Neoplasms (drug therapy), Breast Neoplasms (genetics), DNA, Neoplasm (blood), DNA, Neoplasm (genetics), Disease-Free Survival, Estradiol (administration & dosage), Estradiol (analogs & derivatives), Estradiol (therapeutic use), Estrogen Receptor alpha (blood), Estrogen Receptor alpha (genetics), Female, Humans, Middle Aged, Nitriles (administration & dosage), Piperazines (administration & dosage), Prospective Studies, Pyridines (administration & dosage), Retrospective Studies, Triazoles (administration & dosage).
MESH :
- chemical , administration & dosage : Estradiol, Nitriles, Piperazines, Pyridines, Triazoles.
- chemical , analogs & derivatives : Estradiol.
- chemical , blood : DNA, Neoplasm, Estrogen Receptor alpha.
- chemical , genetics : DNA, Neoplasm, Estrogen Receptor alpha.
- chemical , therapeutic use : Androstadienes, Estradiol.
- blood : Breast Neoplasms.
- drug therapy : Breast Neoplasms.
- genetics : Breast Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Aged, Disease-Free Survival, Female, Humans, Middle Aged, Prospective Studies, Retrospective Studies.

Abstract

ESR1 mutations are selected by prior aromatase inhibitor (AI) therapy in advanced breast cancer. We assessed the impact of ESR1 mutations on sensitivity to standard therapies in two phase III randomized trials that represent the development of the current standard therapy for estrogen receptor-positive advanced breast cancer.

DOI: 10.1200/JCO.2016.67.3061
PubMed: 27269946

Affiliations:

Links toward previous steps (curation, corpus...)

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pubmed:27269946

Le document en format XML

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<author><name sortKey="Beaney, Matthew" sort="Beaney, Matthew" uniqKey="Beaney M" first="Matthew" last="Beaney">Matthew Beaney</name>
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<author><name sortKey="Cristofanilli, Massimo" sort="Cristofanilli, Massimo" uniqKey="Cristofanilli M" first="Massimo" last="Cristofanilli">Massimo Cristofanilli</name>
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<author><name sortKey="Andre, Fabrice" sort="Andre, Fabrice" uniqKey="Andre F" first="Fabrice" last="Andre">Fabrice Andre</name>
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<author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name>
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</placeName>
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</affiliation>
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<author><name sortKey="Loibl, Sibylle" sort="Loibl, Sibylle" uniqKey="Loibl S" first="Sibylle" last="Loibl">Sibylle Loibl</name>
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<author><name sortKey="Jiang, John" sort="Jiang, John" uniqKey="Jiang J" first="John" last="Jiang">John Jiang</name>
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</affiliation>
</author>
<author><name sortKey="Bartlett, Cynthia Huang" sort="Bartlett, Cynthia Huang" uniqKey="Bartlett C" first="Cynthia Huang" last="Bartlett">Cynthia Huang Bartlett</name>
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</affiliation>
</author>
<author><name sortKey="Koehler, Maria" sort="Koehler, Maria" uniqKey="Koehler M" first="Maria" last="Koehler">Maria Koehler</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York</wicri:cityArea>
</affiliation>
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<author><name sortKey="Dowsett, Mitch" sort="Dowsett, Mitch" uniqKey="Dowsett M" first="Mitch" last="Dowsett">Mitch Dowsett</name>
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<author><name sortKey="Johnston, Stephen R D" sort="Johnston, Stephen R D" uniqKey="Johnston S" first="Stephen R D" last="Johnston">Stephen R D. Johnston</name>
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<author><name sortKey="Turner, Nicholas C" sort="Turner, Nicholas C" uniqKey="Turner N" first="Nicholas C" last="Turner">Nicholas C. Turner</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.</title>
<author><name sortKey="Fribbens, Charlotte" sort="Fribbens, Charlotte" uniqKey="Fribbens C" first="Charlotte" last="Fribbens">Charlotte Fribbens</name>
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<author><name sortKey="O Leary, Ben" sort="O Leary, Ben" uniqKey="O Leary B" first="Ben" last="O'Leary">Ben O'Leary</name>
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<author><name sortKey="Kilburn, Lucy" sort="Kilburn, Lucy" uniqKey="Kilburn L" first="Lucy" last="Kilburn">Lucy Kilburn</name>
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<author><name sortKey="Hrebien, Sarah" sort="Hrebien, Sarah" uniqKey="Hrebien S" first="Sarah" last="Hrebien">Sarah Hrebien</name>
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<author><name sortKey="Andre, Fabrice" sort="Andre, Fabrice" uniqKey="Andre F" first="Fabrice" last="Andre">Fabrice Andre</name>
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<author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name>
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<author><name sortKey="Loibl, Sibylle" sort="Loibl, Sibylle" uniqKey="Loibl S" first="Sibylle" last="Loibl">Sibylle Loibl</name>
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<author><name sortKey="Jiang, John" sort="Jiang, John" uniqKey="Jiang J" first="John" last="Jiang">John Jiang</name>
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<author><name sortKey="Bartlett, Cynthia Huang" sort="Bartlett, Cynthia Huang" uniqKey="Bartlett C" first="Cynthia Huang" last="Bartlett">Cynthia Huang Bartlett</name>
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<author><name sortKey="Koehler, Maria" sort="Koehler, Maria" uniqKey="Koehler M" first="Maria" last="Koehler">Maria Koehler</name>
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<author><name sortKey="Dowsett, Mitch" sort="Dowsett, Mitch" uniqKey="Dowsett M" first="Mitch" last="Dowsett">Mitch Dowsett</name>
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<author><name sortKey="Bliss, Judith M" sort="Bliss, Judith M" uniqKey="Bliss J" first="Judith M" last="Bliss">Judith M. Bliss</name>
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<author><name sortKey="Johnston, Stephen R D" sort="Johnston, Stephen R D" uniqKey="Johnston S" first="Stephen R D" last="Johnston">Stephen R D. Johnston</name>
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<author><name sortKey="Turner, Nicholas C" sort="Turner, Nicholas C" uniqKey="Turner N" first="Nicholas C" last="Turner">Nicholas C. Turner</name>
<affiliation wicri:level="2"><nlm:affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY. nicholas.turner@icr.ac.uk.</nlm:affiliation>
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<wicri:cityArea>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York</wicri:cityArea>
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<series><title level="j">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</title>
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<front><div type="abstract" xml:lang="en">ESR1 mutations are selected by prior aromatase inhibitor (AI) therapy in advanced breast cancer. We assessed the impact of ESR1 mutations on sensitivity to standard therapies in two phase III randomized trials that represent the development of the current standard therapy for estrogen receptor-positive advanced breast cancer.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27269946</PMID>
<DateCreated><Year>2016</Year>
<Month>08</Month>
<Day>25</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>07</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1527-7755</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>34</Volume>
<Issue>25</Issue>
<PubDate><Year>2016</Year>
<Month>Sep</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Journal of clinical oncology : official journal of the American Society of Clinical Oncology</Title>
<ISOAbbreviation>J. Clin. Oncol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.</ArticleTitle>
<Pagination><MedlinePgn>2961-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1200/JCO.2016.67.3061</ELocationID>
<Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">ESR1 mutations are selected by prior aromatase inhibitor (AI) therapy in advanced breast cancer. We assessed the impact of ESR1 mutations on sensitivity to standard therapies in two phase III randomized trials that represent the development of the current standard therapy for estrogen receptor-positive advanced breast cancer.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">In a prospective-retrospective analysis, we assessed ESR1 mutations in available archived baseline plasma from the SoFEA (Study of Faslodex Versus Exemestane With or Without Arimidex) trial, which compared exemestane with fulvestrant-containing regimens in patients with prior sensitivity to nonsteroidal AI and in baseline plasma from the PALOMA3 (Palbociclib Combined With Fulvestrant in Hormone Receptor-Positive HER2-Negative Metastatic Breast Cancer After Endocrine Failure) trial, which compared fulvestrant plus placebo with fulvestrant plus palbociclib in patients with progression after receiving prior endocrine therapy. ESR1 mutations were analyzed by multiplex digital polymerase chain reaction.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In SoFEA, ESR1 mutations were found in 39.1% of patients (63 of 161), of whom 49.1% (27 of 55) were polyclonal, with rates of mutation detection unaffected by delays in processing of archival plasma. Patients with ESR1 mutations had improved progression-free survival (PFS) after taking fulvestrant (n = 45) compared with exemestane (n = 18; hazard ratio [HR], 0.52; 95% CI, 0.30 to 0.92; P = .02), whereas patients with wild-type ESR1 had similar PFS after receiving either treatment (HR, 1.07; 95% CI, 0.68 to 1.67; P = .77). In PALOMA3, ESR1 mutations were found in the plasma of 25.3% of patients (91 of 360), of whom 28.6% (26 of 91) were polyclonal, with mutations associated with acquired resistance to prior AI. Fulvestrant plus palbociclib improved PFS compared with fulvestrant plus placebo in both ESR1 mutant (HR, 0.43; 95% CI, 0.25 to 0.74; P = .002) and ESR1 wild-type patients (HR, 0.49; 95% CI, 0.35 to 0.70; P < .001).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">ESR1 mutation analysis in plasma after progression after prior AI therapy may help direct choice of further endocrine-based therapy. Additional confirmatory studies are required.</AbstractText>
<CopyrightInformation>© 2016 by American Society of Clinical Oncology.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fribbens</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>O'Leary</LastName>
<ForeName>Ben</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kilburn</LastName>
<ForeName>Lucy</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hrebien</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garcia-Murillas</LastName>
<ForeName>Isaac</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Beaney</LastName>
<ForeName>Matthew</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cristofanilli</LastName>
<ForeName>Massimo</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Andre</LastName>
<ForeName>Fabrice</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.</Affiliation>
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<Agency>Medical Research Council</Agency>
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<affiliations><list><country><li>États-Unis</li>
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<name sortKey="Jiang, John" sort="Jiang, John" uniqKey="Jiang J" first="John" last="Jiang">John Jiang</name>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.

Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.

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Abstract

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