Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
Identifieur interne : 001869 ( PubMed/Checkpoint ); précédent : 001868; suivant : 001870Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
Auteurs : Bruno Dubois [France] ; Harald Hampel [France] ; Howard H. Feldman [Canada] ; Philip Scheltens [Pays-Bas] ; Paul Aisen [États-Unis] ; Sandrine Andrieu [France] ; Hovagim Bakardjian [France] ; Habib Benali [France] ; Lars Bertram [Royaume-Uni] ; Kaj Blennow [Suède] ; Karl Broich [Allemagne] ; Enrica Cavedo [Italie] ; Sebastian Crutch [Royaume-Uni] ; Jean-François Dartigues [France] ; Charles Duyckaerts [France] ; Stéphane Epelbaum [France] ; Giovanni B. Frisoni [Italie] ; Serge Gauthier [Canada] ; Remy Genthon [France] ; Alida A. Gouw [Pays-Bas] ; Marie-Odile Habert [France] ; David M. Holtzman [États-Unis] ; Miia Kivipelto [Finlande] ; Simone Lista [France] ; José-Luis Molinuevo [Espagne] ; Sid E. O'Bryant [États-Unis] ; Gil D. Rabinovici [États-Unis] ; Christopher Rowe [Australie] ; Stephen Salloway [États-Unis] ; Lon S. Schneider [États-Unis] ; Reisa Sperling [États-Unis] ; Marc Teichmann [France] ; Maria C. Carrillo [États-Unis] ; Jeffrey Cummings [États-Unis] ; Cliff R. Jack [États-Unis]Source :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5279 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Encéphale.
- diagnostic : Maladie d'Alzheimer.
- génétique : Maladie d'Alzheimer.
- imagerie diagnostique : Encéphale, Maladie d'Alzheimer.
- physiopathologie : Maladie d'Alzheimer.
- Animaux, Humains, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Alzheimer Disease.
- diagnostic imaging : Alzheimer Disease, Brain.
- genetics : Alzheimer Disease.
- pathology : Brain.
- physiopathology : Alzheimer Disease.
- Animals, Disease Progression, Humans.
Abstract
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this "silent" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.
DOI: 10.1016/j.jalz.2016.02.002
PubMed: 27012484
Affiliations:
- Allemagne, Australie, Canada, Espagne, Finlande, France, Italie, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Aquitaine, Californie, Catalogne, District de Cologne, Grand Londres, Hollande-Septentrionale, Illinois, Massachusetts, Missouri (État), Nevada, Nouvelle-Aquitaine, Québec, Rhénanie-du-Nord-Westphalie, Texas, Victoria (État), Île-de-France
- Amsterdam, Barcelone, Bonn, Bordeaux, Boston, Chicago, Londres, Los Angeles, Melbourne, Montréal, Paris
- University College de Londres, Université de Bordeaux, Université de Californie du Sud, Université de Melbourne
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:27012484Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.</title><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France. Electronic address: bruno.dubois@aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France; AXA Research Fund & UPMC Chair, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France; AXA Research Fund & UPMC Chair, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Feldman, Howard H" sort="Feldman, Howard H" uniqKey="Feldman H" first="Howard H" last="Feldman">Howard H. Feldman</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Alzheimer Center, VU University Medical Center and Neuroscience Campus, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology and Alzheimer Center, VU University Medical Center and Neuroscience Campus, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Aisen, Paul" sort="Aisen, Paul" uniqKey="Aisen P" first="Paul" last="Aisen">Paul Aisen</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California San Diego, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name><affiliation wicri:level="1"><nlm:affiliation>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital</wicri:regionArea><wicri:noRegion>Toulouse University Hospital</wicri:noRegion><wicri:noRegion>Toulouse University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Bakardjian, Hovagim" sort="Bakardjian, Hovagim" uniqKey="Bakardjian H" first="Hovagim" last="Bakardjian">Hovagim Bakardjian</name><affiliation wicri:level="3"><nlm:affiliation>IHU-A-ICM-Institut des Neurosciences translationnelles de Paris, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-A-ICM-Institut des Neurosciences translationnelles de Paris, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Benali, Habib" sort="Benali, Habib" uniqKey="Benali H" first="Habib" last="Benali">Habib Benali</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U1146-CNRS UMR 7371-UPMC UM CR2, Site Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1146-CNRS UMR 7371-UPMC UM CR2, Site Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:affiliation>Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; School of Public Health, Faculty of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Neurochemistry Lab, Department of Neuroscience and Physiology, University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital, Mölndal, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Neurochemistry Lab, Department of Neuroscience and Physiology, University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation></author><author><name sortKey="Broich, Karl" sort="Broich, Karl" uniqKey="Broich K" first="Karl" last="Broich">Karl Broich</name><affiliation wicri:level="3"><nlm:affiliation>Federal Institute for Drugs and Medical Devices, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Federal Institute for Drugs and Medical Devices, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Cavedo, Enrica" sort="Cavedo, Enrica" uniqKey="Cavedo E" first="Enrica" last="Cavedo">Enrica Cavedo</name><affiliation wicri:level="1"><nlm:affiliation>AXA Research Fund & UPMC Chair, Paris, France; Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris, France; Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Crutch, Sebastian" sort="Crutch, Sebastian" uniqKey="Crutch S" first="Sebastian" last="Crutch">Sebastian Crutch</name><affiliation wicri:level="4"><nlm:affiliation>Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation wicri:level="4"><nlm:affiliation>INSERM U 1219, Université de Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 1219, Université de Bordeaux</wicri:regionArea><wicri:noRegion>Université de Bordeaux</wicri:noRegion><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation wicri:level="3"><nlm:affiliation>University Pierre et Marie Curie, Assistance Publique des Hôpitaux de Paris, Alzheimer-Prion Team Institut du Cerveau et de la Moelle (ICM), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Pierre et Marie Curie, Assistance Publique des Hôpitaux de Paris, Alzheimer-Prion Team Institut du Cerveau et de la Moelle (ICM), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Epelbaum, Stephane" sort="Epelbaum, Stephane" uniqKey="Epelbaum S" first="Stéphane" last="Epelbaum">Stéphane Epelbaum</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B" last="Frisoni">Giovanni B. Frisoni</name><affiliation wicri:level="1"><nlm:affiliation>University Hospitals and University of Geneva, Geneva, Switzerland; IRCCS Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University Hospitals and University of Geneva, Geneva, Switzerland; IRCCS Fatebenefratelli, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Gauthier, Serge" sort="Gauthier, Serge" uniqKey="Gauthier S" first="Serge" last="Gauthier">Serge Gauthier</name><affiliation wicri:level="3"><nlm:affiliation>McGill Center for Studies in Aging, Douglas Mental Health Research Institute, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill Center for Studies in Aging, Douglas Mental Health Research Institute, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Genthon, Remy" sort="Genthon, Remy" uniqKey="Genthon R" first="Remy" last="Genthon">Remy Genthon</name><affiliation wicri:level="3"><nlm:affiliation>Fondation pour la Recherche sur Alzheimer, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fondation pour la Recherche sur Alzheimer, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gouw, Alida A" sort="Gouw, Alida A" uniqKey="Gouw A" first="Alida A" last="Gouw">Alida A. Gouw</name><affiliation wicri:level="3"><nlm:affiliation>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France; Department of Clinical Neurophysiology/MEG Center, VU University Medical Center, Amsterdam.</nlm:affiliation><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><wicri:orgArea>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France; Department of Clinical Neurophysiology/MEG Center, VU University Medical Center</wicri:orgArea></affiliation></author><author><name sortKey="Habert, Marie Odile" sort="Habert, Marie Odile" uniqKey="Habert M" first="Marie-Odile" last="Habert">Marie-Odile Habert</name><affiliation wicri:level="3"><nlm:affiliation>Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France; AP-HP, Hôpital Pitié-Salpêtrière, Département de Médecine Nucléaire, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France; AP-HP, Hôpital Pitié-Salpêtrière, Département de Médecine Nucléaire, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Holtzman, David M" sort="Holtzman, David M" uniqKey="Holtzman D" first="David M" last="Holtzman">David M. Holtzman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Washington University, Hope Center for Neurological Disorders, St. Louis, MO, USA; Department of Neurology, Washington University, Knight Alzheimer's Disease Research Center, St. Louis, MO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University, Hope Center for Neurological Disorders, St. Louis, MO, USA; Department of Neurology, Washington University, Knight Alzheimer's Disease Research Center, St. Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Kivipelto, Miia" sort="Kivipelto, Miia" uniqKey="Kivipelto M" first="Miia" last="Kivipelto">Miia Kivipelto</name><affiliation wicri:level="1"><nlm:affiliation>Center for Alzheimer Research, Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden; Institute of Clinical Medicine/ Neurology, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Center for Alzheimer Research, Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden; Institute of Clinical Medicine/ Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name><affiliation wicri:level="3"><nlm:affiliation>AXA Research Fund & UPMC Chair, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José-Luis" last="Molinuevo">José-Luis Molinuevo</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="O Bryant, Sid E" sort="O Bryant, Sid E" uniqKey="O Bryant S" first="Sid E" last="O'Bryant">Sid E. O'Bryant</name><affiliation wicri:level="2"><nlm:affiliation>Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D" last="Rabinovici">Gil D. Rabinovici</name><affiliation wicri:level="2"><nlm:affiliation>Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rowe, Christopher" sort="Rowe, Christopher" uniqKey="Rowe C" first="Christopher" last="Rowe">Christopher Rowe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Imaging, Austin Health, University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Molecular Imaging, Austin Health, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Salloway, Stephen" sort="Salloway, Stephen" uniqKey="Salloway S" first="Stephen" last="Salloway">Stephen Salloway</name><affiliation wicri:level="1"><nlm:affiliation>Memory and Aging Program, Butler Hospital, Alpert Medical School of Brown University, USA; Department of Neurology, Alpert Medical School of Brown University, USA; Department of Psychiatry, Alpert Medical School of Brown University, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memory and Aging Program, Butler Hospital, Alpert Medical School of Brown University, USA; Department of Neurology, Alpert Medical School of Brown University, USA; Department of Psychiatry, Alpert Medical School of Brown University</wicri:regionArea><wicri:noRegion>Alpert Medical School of Brown University</wicri:noRegion></affiliation></author><author><name sortKey="Schneider, Lon S" sort="Schneider, Lon S" uniqKey="Schneider L" first="Lon S" last="Schneider">Lon S. Schneider</name><affiliation wicri:level="4"><nlm:affiliation>Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Keck School of Medicine of the University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Sperling, Reisa" sort="Sperling, Reisa" uniqKey="Sperling R" first="Reisa" last="Sperling">Reisa Sperling</name><affiliation wicri:level="3"><nlm:affiliation>Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Massachusetts General Hospital, Boston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Massachusetts General Hospital, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Teichmann, Marc" sort="Teichmann, Marc" uniqKey="Teichmann M" first="Marc" last="Teichmann">Marc Teichmann</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Carrillo, Maria C" sort="Carrillo, Maria C" uniqKey="Carrillo M" first="Maria C" last="Carrillo">Maria C. Carrillo</name><affiliation wicri:level="3"><nlm:affiliation>The Alzheimer's Association Division of Medical & Scientific Relations, Chicago, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Alzheimer's Association Division of Medical & Scientific Relations, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Cummings, Jeffrey" sort="Cummings, Jeffrey" uniqKey="Cummings J" first="Jeffrey" last="Cummings">Jeffrey Cummings</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV</wicri:regionArea><placeName><region type="state">Nevada</region></placeName></affiliation></author><author><name sortKey="Jack, Cliff R" sort="Jack, Cliff R" uniqKey="Jack C" first="Cliff R" last="Jack">Cliff R. Jack</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Mayo Clinic, Rochester MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester MN</wicri:regionArea><wicri:noRegion>Rochester MN</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27012484</idno><idno type="pmid">27012484</idno><idno type="doi">10.1016/j.jalz.2016.02.002</idno><idno type="wicri:Area/PubMed/Corpus">002175</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002175</idno><idno type="wicri:Area/PubMed/Curation">002149</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002149</idno><idno type="wicri:Area/PubMed/Checkpoint">002149</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.</title><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France. Electronic address: bruno.dubois@aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France; AXA Research Fund & UPMC Chair, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France; AXA Research Fund & UPMC Chair, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Feldman, Howard H" sort="Feldman, Howard H" uniqKey="Feldman H" first="Howard H" last="Feldman">Howard H. Feldman</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Alzheimer Center, VU University Medical Center and Neuroscience Campus, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology and Alzheimer Center, VU University Medical Center and Neuroscience Campus, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Aisen, Paul" sort="Aisen, Paul" uniqKey="Aisen P" first="Paul" last="Aisen">Paul Aisen</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California San Diego, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name><affiliation wicri:level="1"><nlm:affiliation>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital</wicri:regionArea><wicri:noRegion>Toulouse University Hospital</wicri:noRegion><wicri:noRegion>Toulouse University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Bakardjian, Hovagim" sort="Bakardjian, Hovagim" uniqKey="Bakardjian H" first="Hovagim" last="Bakardjian">Hovagim Bakardjian</name><affiliation wicri:level="3"><nlm:affiliation>IHU-A-ICM-Institut des Neurosciences translationnelles de Paris, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-A-ICM-Institut des Neurosciences translationnelles de Paris, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Benali, Habib" sort="Benali, Habib" uniqKey="Benali H" first="Habib" last="Benali">Habib Benali</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U1146-CNRS UMR 7371-UPMC UM CR2, Site Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1146-CNRS UMR 7371-UPMC UM CR2, Site Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:affiliation>Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; School of Public Health, Faculty of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Neurochemistry Lab, Department of Neuroscience and Physiology, University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital, Mölndal, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Neurochemistry Lab, Department of Neuroscience and Physiology, University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation></author><author><name sortKey="Broich, Karl" sort="Broich, Karl" uniqKey="Broich K" first="Karl" last="Broich">Karl Broich</name><affiliation wicri:level="3"><nlm:affiliation>Federal Institute for Drugs and Medical Devices, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Federal Institute for Drugs and Medical Devices, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Cavedo, Enrica" sort="Cavedo, Enrica" uniqKey="Cavedo E" first="Enrica" last="Cavedo">Enrica Cavedo</name><affiliation wicri:level="1"><nlm:affiliation>AXA Research Fund & UPMC Chair, Paris, France; Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris, France; Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Crutch, Sebastian" sort="Crutch, Sebastian" uniqKey="Crutch S" first="Sebastian" last="Crutch">Sebastian Crutch</name><affiliation wicri:level="4"><nlm:affiliation>Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation wicri:level="4"><nlm:affiliation>INSERM U 1219, Université de Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 1219, Université de Bordeaux</wicri:regionArea><wicri:noRegion>Université de Bordeaux</wicri:noRegion><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation wicri:level="3"><nlm:affiliation>University Pierre et Marie Curie, Assistance Publique des Hôpitaux de Paris, Alzheimer-Prion Team Institut du Cerveau et de la Moelle (ICM), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Pierre et Marie Curie, Assistance Publique des Hôpitaux de Paris, Alzheimer-Prion Team Institut du Cerveau et de la Moelle (ICM), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Epelbaum, Stephane" sort="Epelbaum, Stephane" uniqKey="Epelbaum S" first="Stéphane" last="Epelbaum">Stéphane Epelbaum</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B" last="Frisoni">Giovanni B. Frisoni</name><affiliation wicri:level="1"><nlm:affiliation>University Hospitals and University of Geneva, Geneva, Switzerland; IRCCS Fatebenefratelli, Brescia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University Hospitals and University of Geneva, Geneva, Switzerland; IRCCS Fatebenefratelli, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Gauthier, Serge" sort="Gauthier, Serge" uniqKey="Gauthier S" first="Serge" last="Gauthier">Serge Gauthier</name><affiliation wicri:level="3"><nlm:affiliation>McGill Center for Studies in Aging, Douglas Mental Health Research Institute, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill Center for Studies in Aging, Douglas Mental Health Research Institute, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Genthon, Remy" sort="Genthon, Remy" uniqKey="Genthon R" first="Remy" last="Genthon">Remy Genthon</name><affiliation wicri:level="3"><nlm:affiliation>Fondation pour la Recherche sur Alzheimer, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fondation pour la Recherche sur Alzheimer, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gouw, Alida A" sort="Gouw, Alida A" uniqKey="Gouw A" first="Alida A" last="Gouw">Alida A. Gouw</name><affiliation wicri:level="3"><nlm:affiliation>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France; Department of Clinical Neurophysiology/MEG Center, VU University Medical Center, Amsterdam.</nlm:affiliation><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><wicri:orgArea>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France; Department of Clinical Neurophysiology/MEG Center, VU University Medical Center</wicri:orgArea></affiliation></author><author><name sortKey="Habert, Marie Odile" sort="Habert, Marie Odile" uniqKey="Habert M" first="Marie-Odile" last="Habert">Marie-Odile Habert</name><affiliation wicri:level="3"><nlm:affiliation>Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France; AP-HP, Hôpital Pitié-Salpêtrière, Département de Médecine Nucléaire, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France; AP-HP, Hôpital Pitié-Salpêtrière, Département de Médecine Nucléaire, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Holtzman, David M" sort="Holtzman, David M" uniqKey="Holtzman D" first="David M" last="Holtzman">David M. Holtzman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Washington University, Hope Center for Neurological Disorders, St. Louis, MO, USA; Department of Neurology, Washington University, Knight Alzheimer's Disease Research Center, St. Louis, MO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University, Hope Center for Neurological Disorders, St. Louis, MO, USA; Department of Neurology, Washington University, Knight Alzheimer's Disease Research Center, St. Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Kivipelto, Miia" sort="Kivipelto, Miia" uniqKey="Kivipelto M" first="Miia" last="Kivipelto">Miia Kivipelto</name><affiliation wicri:level="1"><nlm:affiliation>Center for Alzheimer Research, Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden; Institute of Clinical Medicine/ Neurology, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Center for Alzheimer Research, Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden; Institute of Clinical Medicine/ Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name><affiliation wicri:level="3"><nlm:affiliation>AXA Research Fund & UPMC Chair, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José-Luis" last="Molinuevo">José-Luis Molinuevo</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="O Bryant, Sid E" sort="O Bryant, Sid E" uniqKey="O Bryant S" first="Sid E" last="O'Bryant">Sid E. O'Bryant</name><affiliation wicri:level="2"><nlm:affiliation>Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D" last="Rabinovici">Gil D. Rabinovici</name><affiliation wicri:level="2"><nlm:affiliation>Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rowe, Christopher" sort="Rowe, Christopher" uniqKey="Rowe C" first="Christopher" last="Rowe">Christopher Rowe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Imaging, Austin Health, University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Molecular Imaging, Austin Health, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Salloway, Stephen" sort="Salloway, Stephen" uniqKey="Salloway S" first="Stephen" last="Salloway">Stephen Salloway</name><affiliation wicri:level="1"><nlm:affiliation>Memory and Aging Program, Butler Hospital, Alpert Medical School of Brown University, USA; Department of Neurology, Alpert Medical School of Brown University, USA; Department of Psychiatry, Alpert Medical School of Brown University, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memory and Aging Program, Butler Hospital, Alpert Medical School of Brown University, USA; Department of Neurology, Alpert Medical School of Brown University, USA; Department of Psychiatry, Alpert Medical School of Brown University</wicri:regionArea><wicri:noRegion>Alpert Medical School of Brown University</wicri:noRegion></affiliation></author><author><name sortKey="Schneider, Lon S" sort="Schneider, Lon S" uniqKey="Schneider L" first="Lon S" last="Schneider">Lon S. Schneider</name><affiliation wicri:level="4"><nlm:affiliation>Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Keck School of Medicine of the University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Sperling, Reisa" sort="Sperling, Reisa" uniqKey="Sperling R" first="Reisa" last="Sperling">Reisa Sperling</name><affiliation wicri:level="3"><nlm:affiliation>Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Massachusetts General Hospital, Boston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Massachusetts General Hospital, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Teichmann, Marc" sort="Teichmann, Marc" uniqKey="Teichmann M" first="Marc" last="Teichmann">Marc Teichmann</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Carrillo, Maria C" sort="Carrillo, Maria C" uniqKey="Carrillo M" first="Maria C" last="Carrillo">Maria C. Carrillo</name><affiliation wicri:level="3"><nlm:affiliation>The Alzheimer's Association Division of Medical & Scientific Relations, Chicago, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Alzheimer's Association Division of Medical & Scientific Relations, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Cummings, Jeffrey" sort="Cummings, Jeffrey" uniqKey="Cummings J" first="Jeffrey" last="Cummings">Jeffrey Cummings</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV</wicri:regionArea><placeName><region type="state">Nevada</region></placeName></affiliation></author><author><name sortKey="Jack, Cliff R" sort="Jack, Cliff R" uniqKey="Jack C" first="Cliff R" last="Jack">Cliff R. Jack</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Mayo Clinic, Rochester MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester MN</wicri:regionArea><wicri:noRegion>Rochester MN</wicri:noRegion></affiliation></author></analytic><series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title><idno type="eISSN">1552-5279</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (diagnosis)</term><term>Alzheimer Disease (diagnostic imaging)</term><term>Alzheimer Disease (genetics)</term><term>Alzheimer Disease (physiopathology)</term><term>Animals</term><term>Brain (diagnostic imaging)</term><term>Brain (pathology)</term><term>Disease Progression</term><term>Humans</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Encéphale (anatomopathologie)</term><term>Encéphale (imagerie diagnostique)</term><term>Humains</term><term>Maladie d'Alzheimer (diagnostic)</term><term>Maladie d'Alzheimer (génétique)</term><term>Maladie d'Alzheimer (imagerie diagnostique)</term><term>Maladie d'Alzheimer (physiopathologie)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie d'Alzheimer</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Maladie d'Alzheimer</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Encéphale</term><term>Maladie d'Alzheimer</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Maladie d'Alzheimer</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Progression</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this "silent" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27012484</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>25</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>15</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1552-5279</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Alzheimer's & dementia : the journal of the Alzheimer's Association</Title><ISOAbbreviation>Alzheimers Dement</ISOAbbreviation></Journal><ArticleTitle>Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.</ArticleTitle><Pagination><MedlinePgn>292-323</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jalz.2016.02.002</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1552-5260(16)00050-9</ELocationID><Abstract><AbstractText>During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this "silent" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.</AbstractText><CopyrightInformation>Copyright © 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dubois</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France. Electronic address: bruno.dubois@aphp.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hampel</LastName><ForeName>Harald</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France; AXA Research Fund & UPMC Chair, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feldman</LastName><ForeName>Howard H</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>University of British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scheltens</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Neurology and Alzheimer Center, VU University Medical Center and Neuroscience Campus, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aisen</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University of Southern California San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrieu</LastName><ForeName>Sandrine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bakardjian</LastName><ForeName>Hovagim</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>IHU-A-ICM-Institut des Neurosciences translationnelles de Paris, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benali</LastName><ForeName>Habib</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>INSERM U1146-CNRS UMR 7371-UPMC UM CR2, Site Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertram</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; School of Public Health, Faculty of Medicine, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blennow</LastName><ForeName>Kaj</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Clinical Neurochemistry Lab, Department of Neuroscience and Physiology, University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital, Mölndal, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broich</LastName><ForeName>Karl</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Federal Institute for Drugs and Medical Devices, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavedo</LastName><ForeName>Enrica</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>AXA Research Fund & UPMC Chair, Paris, France; Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crutch</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dartigues</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>INSERM U 1219, Université de Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duyckaerts</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University Pierre et Marie Curie, Assistance Publique des Hôpitaux de Paris, Alzheimer-Prion Team Institut du Cerveau et de la Moelle (ICM), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Epelbaum</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frisoni</LastName><ForeName>Giovanni B</ForeName><Initials>GB</Initials><AffiliationInfo><Affiliation>University Hospitals and University of Geneva, Geneva, Switzerland; IRCCS Fatebenefratelli, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gauthier</LastName><ForeName>Serge</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>McGill Center for Studies in Aging, Douglas Mental Health Research Institute, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Genthon</LastName><ForeName>Remy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Fondation pour la Recherche sur Alzheimer, Hôpital Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gouw</LastName><ForeName>Alida A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>UMR1027, INSERM, Université Toulouse III, Toulouse University Hospital, France; Department of Clinical Neurophysiology/MEG Center, VU University Medical Center, Amsterdam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Habert</LastName><ForeName>Marie-Odile</ForeName><Initials>MO</Initials><AffiliationInfo><Affiliation>Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France; AP-HP, Hôpital Pitié-Salpêtrière, Département de Médecine Nucléaire, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holtzman</LastName><ForeName>David M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Washington University, Hope Center for Neurological Disorders, St. Louis, MO, USA; Department of Neurology, Washington University, Knight Alzheimer's Disease Research Center, St. Louis, MO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kivipelto</LastName><ForeName>Miia</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for Alzheimer Research, Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden; Institute of Clinical Medicine/ Neurology, University of Eastern Finland, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lista</LastName><ForeName>Simone</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>AXA Research Fund & UPMC Chair, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molinuevo</LastName><ForeName>José-Luis</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Bryant</LastName><ForeName>Sid E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rabinovici</LastName><ForeName>Gil D</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rowe</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Molecular Imaging, Austin Health, University of Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salloway</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Memory and Aging Program, Butler Hospital, Alpert Medical School of Brown University, USA; Department of Neurology, Alpert Medical School of Brown University, USA; Department of Psychiatry, Alpert Medical School of Brown University, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>Lon S</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sperling</LastName><ForeName>Reisa</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment, Massachusetts General Hospital, Boston, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teichmann</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab, Department of Neurology, AP_HP, Pitié-Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carrillo</LastName><ForeName>Maria C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>The Alzheimer's Association Division of Medical & Scientific Relations, Chicago, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cummings</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jack</LastName><ForeName>Cliff R</ForeName><Initials>CR</Initials><Suffix>Jr</Suffix><AffiliationInfo><Affiliation>Department of Radiology, Mayo Clinic, Rochester MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclinical State of AD”; July 23, 2015; Washington DC, USA</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Alzheimers Dement</MedlineTA><NlmUniqueID>101231978</NlmUniqueID><ISSNLinking>1552-5260</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Alzheimers Dement. 2016 Mar;12(3):213-5</RefSource><PMID Version="1">27012483</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alzheimer's disease</Keyword><Keyword MajorTopicYN="N">Amyloid PET</Keyword><Keyword MajorTopicYN="N">Asymptomatic</Keyword><Keyword MajorTopicYN="N">Biomarkers</Keyword><Keyword MajorTopicYN="N">Blood biomarkers</Keyword><Keyword MajorTopicYN="N">CSF biomarkers</Keyword><Keyword MajorTopicYN="N">Diagnostic criteria</Keyword><Keyword MajorTopicYN="N">Genetics</Keyword><Keyword MajorTopicYN="N">MRI</Keyword><Keyword MajorTopicYN="N">Pathophysiology</Keyword><Keyword MajorTopicYN="N">Preclinical</Keyword><Keyword MajorTopicYN="N">Tau PET</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27012484</ArticleId><ArticleId IdType="pii">S1552-5260(16)00050-9</ArticleId><ArticleId IdType="doi">10.1016/j.jalz.2016.02.002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Californie</li><li>Catalogne</li><li>District de Cologne</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Illinois</li><li>Massachusetts</li><li>Missouri (État)</li><li>Nevada</li><li>Nouvelle-Aquitaine</li><li>Québec</li><li>Rhénanie-du-Nord-Westphalie</li><li>Texas</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Bonn</li><li>Bordeaux</li><li>Boston</li><li>Chicago</li><li>Londres</li><li>Los Angeles</li><li>Melbourne</li><li>Montréal</li><li>Paris</li></settlement><orgName><li>University College de Londres</li><li>Université de Bordeaux</li><li>Université de Californie du Sud</li><li>Université de Melbourne</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name></region><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name><name sortKey="Bakardjian, Hovagim" sort="Bakardjian, Hovagim" uniqKey="Bakardjian H" first="Hovagim" last="Bakardjian">Hovagim Bakardjian</name><name sortKey="Benali, Habib" sort="Benali, Habib" uniqKey="Benali H" first="Habib" last="Benali">Habib Benali</name><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><name sortKey="Epelbaum, Stephane" sort="Epelbaum, Stephane" uniqKey="Epelbaum S" first="Stéphane" last="Epelbaum">Stéphane Epelbaum</name><name sortKey="Genthon, Remy" sort="Genthon, Remy" uniqKey="Genthon R" first="Remy" last="Genthon">Remy Genthon</name><name sortKey="Habert, Marie Odile" sort="Habert, Marie Odile" uniqKey="Habert M" first="Marie-Odile" last="Habert">Marie-Odile Habert</name><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name><name sortKey="Teichmann, Marc" sort="Teichmann, Marc" uniqKey="Teichmann M" first="Marc" last="Teichmann">Marc Teichmann</name></country><country name="Canada"><noRegion><name sortKey="Feldman, Howard H" sort="Feldman, Howard H" uniqKey="Feldman H" first="Howard H" last="Feldman">Howard H. Feldman</name></noRegion><name sortKey="Gauthier, Serge" sort="Gauthier, Serge" uniqKey="Gauthier S" first="Serge" last="Gauthier">Serge Gauthier</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name></region><name sortKey="Gouw, Alida A" sort="Gouw, Alida A" uniqKey="Gouw A" first="Alida A" last="Gouw">Alida A. Gouw</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Aisen, Paul" sort="Aisen, Paul" uniqKey="Aisen P" first="Paul" last="Aisen">Paul Aisen</name></region><name sortKey="Carrillo, Maria C" sort="Carrillo, Maria C" uniqKey="Carrillo M" first="Maria C" last="Carrillo">Maria C. Carrillo</name><name sortKey="Cummings, Jeffrey" sort="Cummings, Jeffrey" uniqKey="Cummings J" first="Jeffrey" last="Cummings">Jeffrey Cummings</name><name sortKey="Holtzman, David M" sort="Holtzman, David M" uniqKey="Holtzman D" first="David M" last="Holtzman">David M. Holtzman</name><name sortKey="Jack, Cliff R" sort="Jack, Cliff R" uniqKey="Jack C" first="Cliff R" last="Jack">Cliff R. Jack</name><name sortKey="O Bryant, Sid E" sort="O Bryant, Sid E" uniqKey="O Bryant S" first="Sid E" last="O'Bryant">Sid E. O'Bryant</name><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D" last="Rabinovici">Gil D. Rabinovici</name><name sortKey="Salloway, Stephen" sort="Salloway, Stephen" uniqKey="Salloway S" first="Stephen" last="Salloway">Stephen Salloway</name><name sortKey="Schneider, Lon S" sort="Schneider, Lon S" uniqKey="Schneider L" first="Lon S" last="Schneider">Lon S. Schneider</name><name sortKey="Sperling, Reisa" sort="Sperling, Reisa" uniqKey="Sperling R" first="Reisa" last="Sperling">Reisa Sperling</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name></region><name sortKey="Crutch, Sebastian" sort="Crutch, Sebastian" uniqKey="Crutch S" first="Sebastian" last="Crutch">Sebastian Crutch</name></country><country name="Suède"><noRegion><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name></noRegion></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Broich, Karl" sort="Broich, Karl" uniqKey="Broich K" first="Karl" last="Broich">Karl Broich</name></region></country><country name="Italie"><noRegion><name sortKey="Cavedo, Enrica" sort="Cavedo, Enrica" uniqKey="Cavedo E" first="Enrica" last="Cavedo">Enrica Cavedo</name></noRegion><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B" last="Frisoni">Giovanni B. Frisoni</name></country><country name="Finlande"><noRegion><name sortKey="Kivipelto, Miia" sort="Kivipelto, Miia" uniqKey="Kivipelto M" first="Miia" last="Kivipelto">Miia Kivipelto</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José-Luis" last="Molinuevo">José-Luis Molinuevo</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Rowe, Christopher" sort="Rowe, Christopher" uniqKey="Rowe C" first="Christopher" last="Rowe">Christopher Rowe</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001869 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001869 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:27012484
|texte= Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:27012484" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |