Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation.
Identifieur interne : 001859 ( PubMed/Checkpoint ); précédent : 001858; suivant : 001860Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation.
Auteurs : Cécile Aubron [Australie] ; Joris Depuydt [Australie] ; François Belon [France] ; Michael Bailey [Australie] ; Matthieu Schmidt [Australie] ; Jayne Sheldrake [Australie] ; Deirdre Murphy [Australie] ; Carlos Scheinkestel [Australie] ; D Jamie Cooper [Australie] ; Gilles Capellier [France] ; Vincent Pellegrino [Australie] ; David Pilcher [Australie] ; Zoe Mcquilten [Australie]Source :
- Annals of intensive care [ 2110-5820 ] ; 2016.
Abstract
Bleeding is the most frequent complication associated with extracorporeal membrane oxygenation (ECMO) support in critically ill patients. Nonetheless, risk factors for bleeding have been poorly described especially those associated with coagulation anomalies and anticoagulant therapy during ECMO support. The aim of this study is to describe bleeding complications in critically ill patients undergoing ECMO and to identify risk factors for bleeding events.
DOI: 10.1186/s13613-016-0196-7
PubMed: 27714705
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Cecile.aubron@chu-brest.fr.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Depuydt, Joris" sort="Depuydt, Joris" uniqKey="Depuydt J" first="Joris" last="Depuydt">Joris Depuydt</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Belon, Francois" sort="Belon, Francois" uniqKey="Belon F" first="François" last="Belon">François Belon</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, Jean Minjoz Hospital, 25030, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>The Intensive Care Unit, Jean Minjoz Hospital, 25030, Besançon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name><affiliation wicri:level="3"><nlm:affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand 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sortKey="Sheldrake, Jayne" sort="Sheldrake, Jayne" uniqKey="Sheldrake J" first="Jayne" last="Sheldrake">Jayne Sheldrake</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Murphy, Deirdre" sort="Murphy, Deirdre" uniqKey="Murphy D" first="Deirdre" last="Murphy">Deirdre Murphy</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Scheinkestel, Carlos" sort="Scheinkestel, Carlos" uniqKey="Scheinkestel C" first="Carlos" last="Scheinkestel">Carlos Scheinkestel</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Cooper, D Jamie" sort="Cooper, D Jamie" uniqKey="Cooper D" first="D Jamie" last="Cooper">D Jamie Cooper</name><affiliation wicri:level="3"><nlm:affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</nlm:affiliation><country 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sortKey="Pellegrino, Vincent" sort="Pellegrino, Vincent" uniqKey="Pellegrino V" first="Vincent" last="Pellegrino">Vincent Pellegrino</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Pilcher, David" sort="Pilcher, David" uniqKey="Pilcher D" first="David" last="Pilcher">David Pilcher</name><affiliation wicri:level="3"><nlm:affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand Intensive Care 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Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Cecile.aubron@chu-brest.fr.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Depuydt, Joris" sort="Depuydt, Joris" uniqKey="Depuydt J" first="Joris" last="Depuydt">Joris Depuydt</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Belon, Francois" sort="Belon, Francois" uniqKey="Belon F" first="François" last="Belon">François Belon</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, Jean Minjoz Hospital, 25030, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>The Intensive Care Unit, Jean Minjoz Hospital, 25030, Besançon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name><affiliation wicri:level="3"><nlm:affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmidt, Matthieu" sort="Schmidt, Matthieu" uniqKey="Schmidt M" first="Matthieu" last="Schmidt">Matthieu Schmidt</name><affiliation wicri:level="3"><nlm:affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sheldrake, Jayne" sort="Sheldrake, Jayne" uniqKey="Sheldrake J" first="Jayne" last="Sheldrake">Jayne Sheldrake</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Murphy, Deirdre" sort="Murphy, Deirdre" uniqKey="Murphy D" first="Deirdre" last="Murphy">Deirdre Murphy</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Scheinkestel, Carlos" sort="Scheinkestel, Carlos" uniqKey="Scheinkestel C" first="Carlos" last="Scheinkestel">Carlos Scheinkestel</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Cooper, D Jamie" sort="Cooper, D Jamie" uniqKey="Cooper D" first="D Jamie" last="Cooper">D Jamie Cooper</name><affiliation wicri:level="3"><nlm:affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Capellier, Gilles" sort="Capellier, Gilles" uniqKey="Capellier G" first="Gilles" last="Capellier">Gilles Capellier</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, Jean Minjoz Hospital, 25030, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>The Intensive Care Unit, Jean Minjoz Hospital, 25030, Besançon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Pellegrino, Vincent" sort="Pellegrino, Vincent" uniqKey="Pellegrino V" first="Vincent" last="Pellegrino">Vincent Pellegrino</name><affiliation wicri:level="3"><nlm:affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Pilcher, David" sort="Pilcher, David" uniqKey="Pilcher D" first="David" last="Pilcher">David Pilcher</name><affiliation wicri:level="3"><nlm:affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Mcquilten, Zoe" sort="Mcquilten, Zoe" uniqKey="Mcquilten Z" first="Zoe" last="Mcquilten">Zoe Mcquilten</name><affiliation wicri:level="3"><nlm:affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Annals of intensive care</title><idno type="ISSN">2110-5820</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bleeding is the most frequent complication associated with extracorporeal membrane oxygenation (ECMO) support in critically ill patients. Nonetheless, risk factors for bleeding have been poorly described especially those associated with coagulation anomalies and anticoagulant therapy during ECMO support. The aim of this study is to describe bleeding complications in critically ill patients undergoing ECMO and to identify risk factors for bleeding events.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27714705</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>07</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2110-5820</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Annals of intensive care</Title><ISOAbbreviation>Ann Intensive Care</ISOAbbreviation></Journal><ArticleTitle>Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation.</ArticleTitle><Pagination><MedlinePgn>97</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13613-016-0196-7</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Bleeding is the most frequent complication associated with extracorporeal membrane oxygenation (ECMO) support in critically ill patients. Nonetheless, risk factors for bleeding have been poorly described especially those associated with coagulation anomalies and anticoagulant therapy during ECMO support. The aim of this study is to describe bleeding complications in critically ill patients undergoing ECMO and to identify risk factors for bleeding events.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We retrospectively analysed ICU charts of adults who received either veno-venous (VV) or veno-arterial (VA) ECMO support in two participating ICUs between 2010 and 2013. Characteristics of patients with and without bleeding complications, as per the Extracorporeal Life Support Organisation (ELSO) definition, were compared, and the impact of bleeding complications on patient outcomes was assessed using survival analysis. Variables that were independently associated with bleeding, including daily clinical and biological variables during ECMO courses, were modelled.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 149 ECMO episodes (111 VA ECMO and 38 VV ECMO) performed in 147 adults, 89 episodes (60 %) were complicated by at least one bleeding event. The most common bleeding sources were: ECMO cannula (37 %), haemothorax or cardiac tamponade (17 %) and ear-nose and throat (16 %). Intra-cranial haemorrhage occurred in five (2.2 %) patients. Bleeding complications were independently associated with worse survival [adjusted hazard ratio (HR) 2.17, 95 % confidence interval (CI) 1.07-4.41, P = 0.03]. Higher activated partial thromboplastin time (aPTT) [adjusted odds ratio (OR) 3.00, 95 % CI 1.64-5.47, P < 0.01], APACHE III score [adjusted OR 1.01, 95 % CI 1.01-1.02, P = 0.01] and ECMO following surgery [adjusted OR 3.04, 95 % CI 1.62-5.69, P < 0.01] were independently associated with greater risk of bleeding occurrence. A similar association between bleeding and higher aPTT was found when non-post-surgical VA ECMO was considered separately.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Bleeding events based on the ELSO bleeding definition occurred in more than 60 % of ECMO episodes and were associated with hospital mortality. We identified higher aPTT prior bleeding as an independent risk factor for bleeding event, suggesting that better control of the aPTT (through a better control of either coagulopathy or anticoagulation) may improve patients' outcome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aubron</LastName><ForeName>Cécile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Cecile.aubron@chu-brest.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Transfusion Research Unit, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Cecile.aubron@chu-brest.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Intensive Care Unit, Centre Hospitalier Régional et Universitaire de Brest, site La Cavale Blanche, Bvd Tanguy Prigent, 29609, Brest Cedex, France. Cecile.aubron@chu-brest.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LUBEM, EA 3882 - Université de Bretagne Occidentale, 29 200 Brest, France. Cecile.aubron@chu-brest.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DePuydt</LastName><ForeName>Joris</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Hospital of Antwerp, 2000, Antwerp, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belon</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>The Intensive Care Unit, Jean Minjoz Hospital, 25030, Besançon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Matthieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpetrière, Assistance Publique-Hôpitaux de Paris, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sheldrake</LastName><ForeName>Jayne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murphy</LastName><ForeName>Deirdre</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scheinkestel</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>D Jamie</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capellier</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>The Intensive Care Unit, Jean Minjoz Hospital, 25030, Besançon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pellegrino</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pilcher</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McQuilten</LastName><ForeName>Zoe</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Transfusion Research Unit, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Ann Intensive Care</MedlineTA><NlmUniqueID>101562873</NlmUniqueID><ISSNLinking>2110-5820</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2009 Nov 4;302(17):1888-95</RefSource><PMID Version="1">19822628</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Atheroscler Thromb. 2015;22(3):265-71</RefSource><PMID Version="1">25186021</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Artif Organs. 2006 Dec;29(12):1121-31</RefSource><PMID Version="1">17219352</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Cardiothorac Surg. 1999 Apr;15(4):508-14</RefSource><PMID Version="1">10371130</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Thromb Res. 2015 Mar;135(3):443-8</RefSource><PMID Version="1">25455998</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Extra Corpor Technol. 2006 Jun;38(2):165-7</RefSource><PMID Version="1">16921692</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care. 2013 Apr 18;17(2):R73</RefSource><PMID Version="1">23594433</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Thorac Surg. 2003 Jul;76(1):129-35</RefSource><PMID Version="1">12842526</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Thorac Surg. 1998 Mar;65(3):712-8</RefSource><PMID Version="1">9527200</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>ASAIO J. 2013 May-Jun;59(3):202-10</RefSource><PMID Version="1">23644605</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Transfus Med Rev. 2015 Apr;29(2):90-101</RefSource><PMID Version="1">25595476</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>ASAIO J. 2016 May-Jun;62(3):302-9</RefSource><PMID Version="1">26720739</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Heart Lung Circ. 2008;17 Suppl 4:S41-7</RefSource><PMID Version="1">18964254</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pediatr Crit Care Med. 2015 Mar;16(3):276-88</RefSource><PMID Version="1">25651048</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Intensive Care. 2015 Feb 11;3(1):6</RefSource><PMID Version="1">25705431</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Intensive Care Med. 2012 Jan;38(1):62-8</RefSource><PMID Version="1">21965100</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pediatr Crit Care Med. 2013 Feb;14(2):e77-84</RefSource><PMID Version="1">23287906</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Intensive Care Med. 2009 Dec;35(12):2105-14</RefSource><PMID Version="1">19768656</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Med. 2008 May;36(5):1404-11</RefSource><PMID Version="1">18434909</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Perfusion. 2015 Nov;30(8):675-82</RefSource><PMID Version="1">25823366</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Resusc. 2013 Sep;15(3):172-8</RefSource><PMID Version="1">23944202</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pediatr Crit Care Med. 2015 Jan;16(1):66-74</RefSource><PMID Version="1">25319630</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anticoagulation</Keyword><Keyword MajorTopicYN="N">Bleeding</Keyword><Keyword MajorTopicYN="N">Coagulopathy</Keyword><Keyword MajorTopicYN="N">Critically ill patients</Keyword><Keyword MajorTopicYN="N">Extra corporeal membrane oxygenation</Keyword><Keyword MajorTopicYN="N">Haemorrhage</Keyword><Keyword MajorTopicYN="N">Thromboembolic events</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27714705</ArticleId><ArticleId IdType="doi">10.1186/s13613-016-0196-7</ArticleId><ArticleId IdType="pii">10.1186/s13613-016-0196-7</ArticleId><ArticleId IdType="pmc">PMC5053950</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Bourgogne-Franche-Comté</li><li>Franche-Comté</li><li>Victoria (État)</li></region><settlement><li>Besançon</li><li>Melbourne</li></settlement></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Aubron, Cecile" sort="Aubron, Cecile" uniqKey="Aubron C" first="Cécile" last="Aubron">Cécile Aubron</name></region><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name><name sortKey="Cooper, D Jamie" sort="Cooper, D Jamie" uniqKey="Cooper D" first="D Jamie" last="Cooper">D Jamie Cooper</name><name sortKey="Depuydt, Joris" sort="Depuydt, Joris" uniqKey="Depuydt J" first="Joris" last="Depuydt">Joris Depuydt</name><name sortKey="Mcquilten, Zoe" sort="Mcquilten, Zoe" uniqKey="Mcquilten Z" first="Zoe" last="Mcquilten">Zoe Mcquilten</name><name sortKey="Murphy, Deirdre" sort="Murphy, Deirdre" uniqKey="Murphy D" first="Deirdre" last="Murphy">Deirdre Murphy</name><name sortKey="Pellegrino, Vincent" sort="Pellegrino, Vincent" uniqKey="Pellegrino V" first="Vincent" last="Pellegrino">Vincent Pellegrino</name><name sortKey="Pilcher, David" sort="Pilcher, David" uniqKey="Pilcher D" first="David" last="Pilcher">David Pilcher</name><name sortKey="Scheinkestel, Carlos" sort="Scheinkestel, Carlos" uniqKey="Scheinkestel C" first="Carlos" last="Scheinkestel">Carlos Scheinkestel</name><name sortKey="Schmidt, Matthieu" sort="Schmidt, Matthieu" uniqKey="Schmidt M" first="Matthieu" last="Schmidt">Matthieu Schmidt</name><name sortKey="Sheldrake, Jayne" sort="Sheldrake, Jayne" uniqKey="Sheldrake J" first="Jayne" last="Sheldrake">Jayne Sheldrake</name></country><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Belon, Francois" sort="Belon, Francois" uniqKey="Belon F" first="François" last="Belon">François Belon</name></region><name sortKey="Capellier, Gilles" sort="Capellier, Gilles" uniqKey="Capellier G" first="Gilles" last="Capellier">Gilles Capellier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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