AustralieFrV1, PubMed, Checkpoint, bibRecord, 001789

Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.

Identifieur interne : 001789 ( PubMed/Checkpoint ); précédent : 001788; suivant : 001790

Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.

Auteurs : S J Lubbe [Royaume-Uni] ; V. Escott-Price [Royaume-Uni] ; A. Brice [France] ; T. Gasser [Allemagne] ; A M Pittman [Royaume-Uni] ; J. Bras [Royaume-Uni] ; J. Hardy [Royaume-Uni] ; P. Heutink [Pays-Bas] ; N M Wood [Royaume-Uni] ; A B Singleton [États-Unis] ; D G Grosset [Royaume-Uni] ; C B Carroll [Royaume-Uni] ; M H Law [Australie] ; F. Demenais [France] ; M M Iles [Royaume-Uni] ; D T Bishop [Royaume-Uni] ; J. Newton-Bishop [Royaume-Uni] ; N M Williams [Royaume-Uni] ; H R Morris [Royaume-Uni]

Source :

Neurobiology of aging [ 1558-1497 ] ; 2016.

RBID : pubmed:27640074

Descripteurs français

English descriptors

KwdEn :
- Cohort Studies, Dopamine (biosynthesis), Genetic Association Studies, Genetic Predisposition to Disease (genetics), Genetic Variation (genetics), Genotype, Humans, Melanins (biosynthesis), Melanoma (genetics), Membrane Glycoproteins (genetics), Monophenol Monooxygenase, Oxidoreductases (genetics), Parkinson Disease (genetics), Pigmentation (genetics), Receptor, ErbB-4 (genetics), Receptors, Cell Surface (genetics), Risk, Skin Neoplasms (genetics), Tumor Suppressor Proteins (genetics), Ubiquitin Thiolesterase (genetics).
MESH :
- chemical , biosynthesis : Dopamine, Melanins.
- genetics : Genetic Predisposition to Disease, Genetic Variation, Melanoma, Membrane Glycoproteins, Oxidoreductases, Parkinson Disease, Pigmentation, Receptor, ErbB-4, Receptors, Cell Surface, Skin Neoplasms, Tumor Suppressor Proteins, Ubiquitin Thiolesterase.
- Cohort Studies, Genetic Association Studies, Genotype, Humans, Monophenol Monooxygenase, Risk.

Abstract

A shared genetic susceptibility between cutaneous malignant melanoma (CMM) and Parkinson's disease (PD) has been suggested. We investigated this by assessing the contribution of rare variants in genes involved in CMM to PD risk. We studied rare variation across 29 CMM risk genes using high-quality genotype data in 6875 PD cases and 6065 controls and sought to replicate findings using whole-exome sequencing data from a second independent cohort totaling 1255 PD cases and 473 controls. No statistically significant enrichment of rare variants across all genes, per gene, or for any individual variant was detected in either cohort. There were nonsignificant trends toward different carrier frequencies between PD cases and controls, under different inheritance models, in the following CMM risk genes: BAP1, DCC, ERBB4, KIT, MAPK2, MITF, PTEN, and TP53. The very rare TYR p.V275F variant, which is a pathogenic allele for recessive albinism, was more common in PD cases than controls in 3 independent cohorts. Tyrosinase, encoded by TYR, is the rate-limiting enzyme for the production of neuromelanin, and has a role in the production of dopamine. These results suggest a possible role for another gene in the dopamine-biosynthetic pathway in susceptibility to neurodegenerative Parkinsonism, but further studies in larger PD cohorts are needed to accurately determine the role of these genes/variants in disease pathogenesis.

DOI: 10.1016/j.neurobiolaging.2016.07.013
PubMed: 27640074

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001538
to stream PubMed, to step Curation: 001516

Links to Exploration step

pubmed:27640074

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.</title>
<author><name sortKey="Lubbe, S J" sort="Lubbe, S J" uniqKey="Lubbe S" first="S J" last="Lubbe">S J Lubbe</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escott Price, V" sort="Escott Price, V" uniqKey="Escott Price V" first="V" last="Escott-Price">V. Escott-Price</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Epinière, ICM, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Epinière, ICM</wicri:regionArea>
<wicri:noRegion>ICM</wicri:noRegion>
<wicri:noRegion>ICM</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name>
<affiliation wicri:level="3"><nlm:affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pittman, A M" sort="Pittman, A M" uniqKey="Pittman A" first="A M" last="Pittman">A M Pittman</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bras, J" sort="Bras, J" uniqKey="Bras J" first="J" last="Bras">J. Bras</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J" last="Hardy">J. Hardy</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P" last="Heutink">P. Heutink</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wood, N M" sort="Wood, N M" uniqKey="Wood N" first="N M" last="Wood">N M Wood</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom; UCL Genetics Institute, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom; UCL Genetics Institute, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singleton, A B" sort="Singleton, A B" uniqKey="Singleton A" first="A B" last="Singleton">A B Singleton</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grosset, D G" sort="Grosset, D G" uniqKey="Grosset D" first="D G" last="Grosset">D G Grosset</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow</wicri:regionArea>
<wicri:noRegion>Glasgow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carroll, C B" sort="Carroll, C B" uniqKey="Carroll C" first="C B" last="Carroll">C B Carroll</name>
<affiliation wicri:level="1"><nlm:affiliation>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth</wicri:regionArea>
<wicri:noRegion>Plymouth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Law, M H" sort="Law, M H" uniqKey="Law M" first="M H" last="Law">M H Law</name>
<affiliation wicri:level="1"><nlm:affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demenais, F" sort="Demenais, F" uniqKey="Demenais F" first="F" last="Demenais">F. Demenais</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR 946, Genetic Variation and Human Diseases Unit, Paris, France; Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, UMR 946, Genetic Variation and Human Diseases Unit, Paris, France; Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Iles, M M" sort="Iles, M M" uniqKey="Iles M" first="M M" last="Iles">M M Iles</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bishop, D T" sort="Bishop, D T" uniqKey="Bishop D" first="D T" last="Bishop">D T Bishop</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newton Bishop, J" sort="Newton Bishop, J" uniqKey="Newton Bishop J" first="J" last="Newton-Bishop">J. Newton-Bishop</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williams, N M" sort="Williams, N M" uniqKey="Williams N" first="N M" last="Williams">N M Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morris, H R" sort="Morris, H R" uniqKey="Morris H" first="H R" last="Morris">H R Morris</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom. Electronic address: h.morris@ucl.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27640074</idno>
<idno type="pmid">27640074</idno>
<idno type="doi">10.1016/j.neurobiolaging.2016.07.013</idno>
<idno type="wicri:Area/PubMed/Corpus">001538</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001538</idno>
<idno type="wicri:Area/PubMed/Curation">001516</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001516</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001516</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001516</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.</title>
<author><name sortKey="Lubbe, S J" sort="Lubbe, S J" uniqKey="Lubbe S" first="S J" last="Lubbe">S J Lubbe</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escott Price, V" sort="Escott Price, V" uniqKey="Escott Price V" first="V" last="Escott-Price">V. Escott-Price</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Epinière, ICM, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Epinière, ICM</wicri:regionArea>
<wicri:noRegion>ICM</wicri:noRegion>
<wicri:noRegion>ICM</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name>
<affiliation wicri:level="3"><nlm:affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pittman, A M" sort="Pittman, A M" uniqKey="Pittman A" first="A M" last="Pittman">A M Pittman</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bras, J" sort="Bras, J" uniqKey="Bras J" first="J" last="Bras">J. Bras</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J" last="Hardy">J. Hardy</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P" last="Heutink">P. Heutink</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wood, N M" sort="Wood, N M" uniqKey="Wood N" first="N M" last="Wood">N M Wood</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom; UCL Genetics Institute, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom; UCL Genetics Institute, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singleton, A B" sort="Singleton, A B" uniqKey="Singleton A" first="A B" last="Singleton">A B Singleton</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grosset, D G" sort="Grosset, D G" uniqKey="Grosset D" first="D G" last="Grosset">D G Grosset</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow</wicri:regionArea>
<wicri:noRegion>Glasgow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carroll, C B" sort="Carroll, C B" uniqKey="Carroll C" first="C B" last="Carroll">C B Carroll</name>
<affiliation wicri:level="1"><nlm:affiliation>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth</wicri:regionArea>
<wicri:noRegion>Plymouth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Law, M H" sort="Law, M H" uniqKey="Law M" first="M H" last="Law">M H Law</name>
<affiliation wicri:level="1"><nlm:affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demenais, F" sort="Demenais, F" uniqKey="Demenais F" first="F" last="Demenais">F. Demenais</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR 946, Genetic Variation and Human Diseases Unit, Paris, France; Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, UMR 946, Genetic Variation and Human Diseases Unit, Paris, France; Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Iles, M M" sort="Iles, M M" uniqKey="Iles M" first="M M" last="Iles">M M Iles</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bishop, D T" sort="Bishop, D T" uniqKey="Bishop D" first="D T" last="Bishop">D T Bishop</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newton Bishop, J" sort="Newton Bishop, J" uniqKey="Newton Bishop J" first="J" last="Newton-Bishop">J. Newton-Bishop</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williams, N M" sort="Williams, N M" uniqKey="Williams N" first="N M" last="Williams">N M Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morris, H R" sort="Morris, H R" uniqKey="Morris H" first="H R" last="Morris">H R Morris</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom. Electronic address: h.morris@ucl.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuroscience, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Neurobiology of aging</title>
<idno type="eISSN">1558-1497</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cohort Studies</term>
<term>Dopamine (biosynthesis)</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genetic Variation (genetics)</term>
<term>Genotype</term>
<term>Humans</term>
<term>Melanins (biosynthesis)</term>
<term>Melanoma (genetics)</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Monophenol Monooxygenase</term>
<term>Oxidoreductases (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Pigmentation (genetics)</term>
<term>Receptor, ErbB-4 (genetics)</term>
<term>Receptors, Cell Surface (genetics)</term>
<term>Risk</term>
<term>Skin Neoplasms (genetics)</term>
<term>Tumor Suppressor Proteins (genetics)</term>
<term>Ubiquitin Thiolesterase (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Dopamine (biosynthèse)</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Génotype</term>
<term>Humains</term>
<term>Maladie de Parkinson (génétique)</term>
<term>Monophenol monooxygenase</term>
<term>Mélanines (biosynthèse)</term>
<term>Mélanome (génétique)</term>
<term>Oxidoreductases (génétique)</term>
<term>Pigmentation (génétique)</term>
<term>Protéines suppresseurs de tumeurs (génétique)</term>
<term>Prédisposition génétique à une maladie (génétique)</term>
<term>Risque</term>
<term>Récepteur ErbB-4 (génétique)</term>
<term>Récepteurs de surface cellulaire (génétique)</term>
<term>Tumeurs cutanées (génétique)</term>
<term>Ubiquitin thiolesterase (génétique)</term>
<term>Variation génétique (génétique)</term>
<term>Études d'associations génétiques</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Dopamine</term>
<term>Melanins</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Dopamine</term>
<term>Mélanines</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term>
<term>Genetic Variation</term>
<term>Melanoma</term>
<term>Membrane Glycoproteins</term>
<term>Oxidoreductases</term>
<term>Parkinson Disease</term>
<term>Pigmentation</term>
<term>Receptor, ErbB-4</term>
<term>Receptors, Cell Surface</term>
<term>Skin Neoplasms</term>
<term>Tumor Suppressor Proteins</term>
<term>Ubiquitin Thiolesterase</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Maladie de Parkinson</term>
<term>Mélanome</term>
<term>Oxidoreductases</term>
<term>Pigmentation</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Prédisposition génétique à une maladie</term>
<term>Récepteur ErbB-4</term>
<term>Récepteurs de surface cellulaire</term>
<term>Tumeurs cutanées</term>
<term>Ubiquitin thiolesterase</term>
<term>Variation génétique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term>
<term>Genetic Association Studies</term>
<term>Genotype</term>
<term>Humans</term>
<term>Monophenol Monooxygenase</term>
<term>Risk</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Génotype</term>
<term>Humains</term>
<term>Monophenol monooxygenase</term>
<term>Risque</term>
<term>Études d'associations génétiques</term>
<term>Études de cohortes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A shared genetic susceptibility between cutaneous malignant melanoma (CMM) and Parkinson's disease (PD) has been suggested. We investigated this by assessing the contribution of rare variants in genes involved in CMM to PD risk. We studied rare variation across 29 CMM risk genes using high-quality genotype data in 6875 PD cases and 6065 controls and sought to replicate findings using whole-exome sequencing data from a second independent cohort totaling 1255 PD cases and 473 controls. No statistically significant enrichment of rare variants across all genes, per gene, or for any individual variant was detected in either cohort. There were nonsignificant trends toward different carrier frequencies between PD cases and controls, under different inheritance models, in the following CMM risk genes: BAP1, DCC, ERBB4, KIT, MAPK2, MITF, PTEN, and TP53. The very rare TYR p.V275F variant, which is a pathogenic allele for recessive albinism, was more common in PD cases than controls in 3 independent cohorts. Tyrosinase, encoded by TYR, is the rate-limiting enzyme for the production of neuromelanin, and has a role in the production of dopamine. These results suggest a possible role for another gene in the dopamine-biosynthetic pathway in susceptibility to neurodegenerative Parkinsonism, but further studies in larger PD cohorts are needed to accurately determine the role of these genes/variants in disease pathogenesis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27640074</PMID>
<DateCreated><Year>2016</Year>
<Month>09</Month>
<Day>18</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>10</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-1497</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>48</Volume>
<PubDate><Year>2016</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Neurobiology of aging</Title>
<ISOAbbreviation>Neurobiol. Aging</ISOAbbreviation>
</Journal>
<ArticleTitle>Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>222.e1-222.e7</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0197-4580(16)30150-6</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurobiolaging.2016.07.013</ELocationID>
<Abstract><AbstractText>A shared genetic susceptibility between cutaneous malignant melanoma (CMM) and Parkinson's disease (PD) has been suggested. We investigated this by assessing the contribution of rare variants in genes involved in CMM to PD risk. We studied rare variation across 29 CMM risk genes using high-quality genotype data in 6875 PD cases and 6065 controls and sought to replicate findings using whole-exome sequencing data from a second independent cohort totaling 1255 PD cases and 473 controls. No statistically significant enrichment of rare variants across all genes, per gene, or for any individual variant was detected in either cohort. There were nonsignificant trends toward different carrier frequencies between PD cases and controls, under different inheritance models, in the following CMM risk genes: BAP1, DCC, ERBB4, KIT, MAPK2, MITF, PTEN, and TP53. The very rare TYR p.V275F variant, which is a pathogenic allele for recessive albinism, was more common in PD cases than controls in 3 independent cohorts. Tyrosinase, encoded by TYR, is the rate-limiting enzyme for the production of neuromelanin, and has a role in the production of dopamine. These results suggest a possible role for another gene in the dopamine-biosynthetic pathway in susceptibility to neurodegenerative Parkinsonism, but further studies in larger PD cohorts are needed to accurately determine the role of these genes/variants in disease pathogenesis.</AbstractText>
<CopyrightInformation>Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lubbe</LastName>
<ForeName>S J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Escott-Price</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brice</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Epinière, ICM, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gasser</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pittman</LastName>
<ForeName>A M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bras</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hardy</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heutink</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wood</LastName>
<ForeName>N M</ForeName>
<Initials>NM</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom; UCL Genetics Institute, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Singleton</LastName>
<ForeName>A B</ForeName>
<Initials>AB</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grosset</LastName>
<ForeName>D G</ForeName>
<Initials>DG</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carroll</LastName>
<ForeName>C B</ForeName>
<Initials>CB</Initials>
<AffiliationInfo><Affiliation>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Law</LastName>
<ForeName>M H</ForeName>
<Initials>MH</Initials>
<AffiliationInfo><Affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Demenais</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR 946, Genetic Variation and Human Diseases Unit, Paris, France; Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Iles</LastName>
<ForeName>M M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Melanoma Meta-Analysis Consortium</CollectiveName>
</Author>
<Author ValidYN="Y"><LastName>Bishop</LastName>
<ForeName>D T</ForeName>
<Initials>DT</Initials>
<AffiliationInfo><Affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Newton-Bishop</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Williams</LastName>
<ForeName>N M</ForeName>
<Initials>NM</Initials>
<AffiliationInfo><Affiliation>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morris</LastName>
<ForeName>H R</ForeName>
<Initials>HR</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neuroscience, UCL Institute of Neurology, London, United Kingdom. Electronic address: h.morris@ucl.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>International Parkinson's Disease Genomics Consortium</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>Z01 AG000949</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 CA141668</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>G1100643</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>K-1501</GrantID>
<Agency>Parkinson's UK</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>R01 NS037167</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>G0501542</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>Z01 ES101986</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P50 NS071674</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>G0700943</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>07</Month>
<Day>28</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Neurobiol Aging</MedlineTA>
<NlmUniqueID>8100437</NlmUniqueID>
<ISSNLinking>0197-4580</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C501909">DCC protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008543">Melanins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011956">Receptors, Cell Surface</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D025521">Tumor Suppressor Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C014121">neuromelanin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.-</RegistryNumber>
<NameOfSubstance UI="D010088">Oxidoreductases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.14.18.-</RegistryNumber>
<NameOfSubstance UI="C489799">TYRP1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.14.18.1</RegistryNumber>
<NameOfSubstance UI="D014442">Monophenol Monooxygenase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="C587689">ERBB4 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="D066247">Receptor, ErbB-4</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.2.15</RegistryNumber>
<NameOfSubstance UI="C400134">BAP1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.19.12</RegistryNumber>
<NameOfSubstance UI="D043222">Ubiquitin Thiolesterase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber>
<NameOfSubstance UI="D004298">Dopamine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2015 Dec 1;24(23 ):6711-20</RefSource>
<PMID Version="1">26362251</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Stat Med. 2002 Jun 15;21(11):1539-58</RefSource>
<PMID Version="1">12111919</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Cancer. 2014 Sep;50(14):2456-62</RefSource>
<PMID Version="1">25065294</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Jan 10;493(7431):216-20</RefSource>
<PMID Version="1">23201682</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2005 Mar;7(3):263-73</RefSource>
<PMID Version="1">15766664</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2012 Jul 6;337(6090):64-9</RefSource>
<PMID Version="1">22604720</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2016 Jan;79(1):159-61</RefSource>
<PMID Version="1">26389967</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Jul;19(7):807-11</RefSource>
<PMID Version="1">15254939</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2014 Jun;35(6):1512.e5-10</RefSource>
<PMID Version="1">24439955</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Med Hypotheses. 2009 Mar;72(3):280-4</RefSource>
<PMID Version="1">19027242</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2009 Sep;19(9):1553-61</RefSource>
<PMID Version="1">19602639</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Epidemiology. 2002 Mar;13(2):157-64</RefSource>
<PMID Version="1">11880756</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Psychother Psychosom. 2014;83(2):89-105</RefSource>
<PMID Version="1">24458030</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2009 Jan;65(1):76-82</RefSource>
<PMID Version="1">19194882</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2010 Sep;20(9):1297-303</RefSource>
<PMID Version="1">20644199</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E455-64</RefSource>
<PMID Version="1">24443550</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2014 Jan 1;179(1):85-94</RefSource>
<PMID Version="1">24142916</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2010 Aug;7(8):575-6</RefSource>
<PMID Version="1">20676075</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Cancer. 2011 May 15;128(10):2251-60</RefSource>
<PMID Version="1">21207412</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2015 Mar;36(3):1605.e7-12</RefSource>
<PMID Version="1">25444595</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2011 Oct 24;11(11):812-23</RefSource>
<PMID Version="1">22020207</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2010 Apr;7(4):248-9</RefSource>
<PMID Version="1">20354512</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2005 Jun;20(6):719-25</RefSource>
<PMID Version="1">15704188</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2009 Oct 20;73(16):1286-91</RefSource>
<PMID Version="1">19841380</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010 May 05;5(5):e10481</RefSource>
<PMID Version="1">20463956</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochem J. 2003 Jul 1;373(Pt 1):25-32</RefSource>
<PMID Version="1">12683952</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2015 May;77(5):889-94</RefSource>
<PMID Version="1">25631192</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Comput Biol. 2010 Dec 02;6(12):e1001025</RefSource>
<PMID Version="1">21152010</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2015 Jan;36(1):545.e9-14</RefSource>
<PMID Version="1">25174650</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Causes Control. 2010 May;21(5):697-707</RefSource>
<PMID Version="1">20054708</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2012 Nov;11(11):986-98</RefSource>
<PMID Version="1">23079555</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2001 May;11(5):863-74</RefSource>
<PMID Version="1">11337480</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2003 May 13;100(10 ):5956-61</RefSource>
<PMID Version="1">12719539</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>FEBS Lett. 2006 Apr 3;580(8):2147-52</RefSource>
<PMID Version="1">16567160</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2010 Apr;67(4):553-4</RefSource>
<PMID Version="1">20437597</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):243-5</RefSource>
<PMID Version="1">22086882</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 1991 Oct 15;51(20):5449-53</RefSource>
<PMID Version="1">1680551</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Death Dis. 2013 Jan 10;4:e455</RefSource>
<PMID Version="1">23303129</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Epidemiology. 2006 Sep;17(5):582-7</RefSource>
<PMID Version="1">16837822</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2010 Jan;20(1):110-21</RefSource>
<PMID Version="1">19858363</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 2014 Sep;137(Pt 9):2480-92</RefSource>
<PMID Version="1">24993959</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2011 Jul 15;89(1):82-93</RefSource>
<PMID Version="1">21737059</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2010 Mar;16(3):186-90</RefSource>
<PMID Version="1">19945903</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochemistry. 2011 Nov 1;50(43):9399-408</RefSource>
<PMID Version="1">21961647</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2009 Jul 15;25(14):1754-60</RefSource>
<PMID Version="1">19451168</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Prog Neurobiol. 2005 Feb;75(2):109-24</RefSource>
<PMID Version="1">15784302</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2012 Dec;69(12):1572-7</RefSource>
<PMID Version="1">22945795</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Cancer. 2005 Jan 17;92(1):201-5</RefSource>
<PMID Version="1">15583688</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 2003 Nov;26(11):578-80</RefSource>
<PMID Version="1">14585596</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2010 Sep;38(16):e164</RefSource>
<PMID Version="1">20601685</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2013 Nov 7;93(5):900-5</RefSource>
<PMID Version="1">24119685</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2009 Jun;65(6):759; author reply 759</RefSource>
<PMID Version="1">19557863</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol. 2014 Feb;261(2):259-66</RefSource>
<PMID Version="1">23798000</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Res Mol Brain Res. 1997 Apr;45(1):159-62</RefSource>
<PMID Version="1">9105685</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056726" MajorTopicYN="Y">Genetic Association Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008543" MajorTopicYN="N">Melanins</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008545" MajorTopicYN="N">Melanoma</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014442" MajorTopicYN="N">Monophenol Monooxygenase</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010088" MajorTopicYN="N">Oxidoreductases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010858" MajorTopicYN="N">Pigmentation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D066247" MajorTopicYN="N">Receptor, ErbB-4</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011956" MajorTopicYN="N">Receptors, Cell Surface</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012878" MajorTopicYN="N">Skin Neoplasms</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025521" MajorTopicYN="N">Tumor Suppressor Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D043222" MajorTopicYN="N">Ubiquitin Thiolesterase</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cutaneous malignant melanoma</Keyword>
<Keyword MajorTopicYN="N">Parkinson's</Keyword>
<Keyword MajorTopicYN="N">Pigmentation</Keyword>
<Keyword MajorTopicYN="N">Shared genetic background</Keyword>
<Keyword MajorTopicYN="N">Tyrosinase</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>02</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>07</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>07</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>10</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27640074</ArticleId>
<ArticleId IdType="pii">S0197-4580(16)30150-6</ArticleId>
<ArticleId IdType="doi">10.1016/j.neurobiolaging.2016.07.013</ArticleId>
<ArticleId IdType="pmc">PMC5096891</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Maryland</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Londres</li>
<li>Paris</li>
<li>Tübingen</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lubbe, S J" sort="Lubbe, S J" uniqKey="Lubbe S" first="S J" last="Lubbe">S J Lubbe</name>
</region>
<name sortKey="Bishop, D T" sort="Bishop, D T" uniqKey="Bishop D" first="D T" last="Bishop">D T Bishop</name>
<name sortKey="Bras, J" sort="Bras, J" uniqKey="Bras J" first="J" last="Bras">J. Bras</name>
<name sortKey="Carroll, C B" sort="Carroll, C B" uniqKey="Carroll C" first="C B" last="Carroll">C B Carroll</name>
<name sortKey="Escott Price, V" sort="Escott Price, V" uniqKey="Escott Price V" first="V" last="Escott-Price">V. Escott-Price</name>
<name sortKey="Grosset, D G" sort="Grosset, D G" uniqKey="Grosset D" first="D G" last="Grosset">D G Grosset</name>
<name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J" last="Hardy">J. Hardy</name>
<name sortKey="Iles, M M" sort="Iles, M M" uniqKey="Iles M" first="M M" last="Iles">M M Iles</name>
<name sortKey="Morris, H R" sort="Morris, H R" uniqKey="Morris H" first="H R" last="Morris">H R Morris</name>
<name sortKey="Newton Bishop, J" sort="Newton Bishop, J" uniqKey="Newton Bishop J" first="J" last="Newton-Bishop">J. Newton-Bishop</name>
<name sortKey="Pittman, A M" sort="Pittman, A M" uniqKey="Pittman A" first="A M" last="Pittman">A M Pittman</name>
<name sortKey="Williams, N M" sort="Williams, N M" uniqKey="Williams N" first="N M" last="Williams">N M Williams</name>
<name sortKey="Wood, N M" sort="Wood, N M" uniqKey="Wood N" first="N M" last="Wood">N M Wood</name>
</country>
<country name="France"><noRegion><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name>
</noRegion>
<name sortKey="Demenais, F" sort="Demenais, F" uniqKey="Demenais F" first="F" last="Demenais">F. Demenais</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name>
</region>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P" last="Heutink">P. Heutink</name>
</region>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Singleton, A B" sort="Singleton, A B" uniqKey="Singleton A" first="A B" last="Singleton">A B Singleton</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Law, M H" sort="Law, M H" uniqKey="Law M" first="M H" last="Law">M H Law</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001789 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001789 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:27640074
   |texte=   Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:27640074" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.

Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki