AustralieFrV1, PubMed, Checkpoint, bibRecord, 001607

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.

Identifieur interne : 001607 ( PubMed/Checkpoint ); précédent : 001606; suivant : 001608

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.

Auteurs : Brigitta G. Baumert [Allemagne] ; Monika E. Hegi [Suisse] ; Martin J. Van Den Bent [Pays-Bas] ; Andreas Von Deimling [Allemagne] ; Thierry Gorlia [Belgique] ; Khê Hoang-Xuan [France] ; Alba A. Brandes [Italie] ; Guy Kantor [France] ; Martin J B. Taphoorn [Pays-Bas] ; Mohamed Ben Hassel [France] ; Christian Hartmann [Allemagne] ; Gail Ryan [Australie] ; David Capper [Allemagne] ; Johan M. Kros [Pays-Bas] ; Sebastian Kurscheid [Australie] ; Wolfgang Wick [Allemagne] ; Roelien Enting [Pays-Bas] ; Michele Reni [Italie] ; Brian Thiessen [Canada] ; Frederic Dhermain [France] ; Jacoline E. Bromberg [Pays-Bas] ; Loic Feuvret [France] ; Jaap C. Reijneveld [Pays-Bas] ; Olivier Chinot [France] ; Johanna M M. Gijtenbeek [Pays-Bas] ; John P. Rossiter [Canada] ; Nicolas Dif [Belgique] ; Carmen Balana [Espagne] ; Jose Bravo-Marques [Portugal] ; Paul M. Clement [Belgique] ; Christine Marosi [Autriche] ; Tzahala Tzuk-Shina [Israël] ; Robert A. Nordal [Canada] ; Jeremy Rees [Royaume-Uni] ; Denis Lacombe [Belgique] ; Warren P. Mason [Canada] ; Roger Stupp [Suisse]

Source :

The Lancet. Oncology [ 1474-5488 ] ; 2016.

RBID : pubmed:27686946

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Antinéoplasiques alcoylants (usage thérapeutique), Dacarbazine (analogues et dérivés), Dacarbazine (usage thérapeutique), Gliome (), Gliome (mortalité), Humains, Isocitrate dehydrogenases (génétique), Mâle, Radiothérapie conformationnelle, Tumeurs du cerveau (), Tumeurs du cerveau (mortalité).
MESH :
- analogues et dérivés : Dacarbazine.
- génétique : Isocitrate dehydrogenases.
- mortalité : Gliome, Tumeurs du cerveau.
- usage thérapeutique : Antinéoplasiques alcoylants, Dacarbazine.
- Adulte, Adulte d'âge moyen, Gliome, Humains, Mâle, Radiothérapie conformationnelle, Tumeurs du cerveau.

English descriptors

KwdEn :
- Adult, Antineoplastic Agents, Alkylating (therapeutic use), Brain Neoplasms (mortality), Brain Neoplasms (therapy), Dacarbazine (analogs & derivatives), Dacarbazine (therapeutic use), Glioma (mortality), Glioma (therapy), Humans, Isocitrate Dehydrogenase (genetics), Male, Middle Aged, Radiotherapy, Conformal.
MESH :
- chemical , analogs & derivatives : Dacarbazine.
- chemical , genetics : Isocitrate Dehydrogenase.
- chemical , therapeutic use : Antineoplastic Agents, Alkylating, Dacarbazine.
- mortality : Brain Neoplasms, Glioma.
- therapy : Brain Neoplasms, Glioma.
- Adult, Humans, Male, Middle Aged, Radiotherapy, Conformal.

Abstract

Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors.

DOI: 10.1016/S1470-2045(16)30313-8
PubMed: 27686946

Affiliations:

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Le document en format XML

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<author><name sortKey="Baumert, Brigitta G" sort="Baumert, Brigitta G" uniqKey="Baumert B" first="Brigitta G" last="Baumert">Brigitta G. Baumert</name>
<affiliation wicri:level="3"><nlm:affiliation>Maastricht University Medical Centre and GROW (School for Oncology), Maastricht, Netherlands; MediClin Robert-Janker-Clinic/Clinical Cooperation Unit of Neurooncology, University Bonn Medical Centre, Bonn, Germany. Electronic address: brigitta.baumert@gmail.com.</nlm:affiliation>
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<wicri:regionArea>Maastricht University Medical Centre and GROW (School for Oncology), Maastricht, Netherlands; MediClin Robert-Janker-Clinic/Clinical Cooperation Unit of Neurooncology, University Bonn Medical Centre, Bonn</wicri:regionArea>
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<author><name sortKey="Hegi, Monika E" sort="Hegi, Monika E" uniqKey="Hegi M" first="Monika E" last="Hegi">Monika E. Hegi</name>
<affiliation wicri:level="3"><nlm:affiliation>Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Lausanne University Hospital, Lausanne</wicri:regionArea>
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<author><name sortKey="Van Den Bent, Martin J" sort="Van Den Bent, Martin J" uniqKey="Van Den Bent M" first="Martin J" last="Van Den Bent">Martin J. Van Den Bent</name>
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<country xml:lang="fr">Pays-Bas</country>
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<author><name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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<author><name sortKey="Gorlia, Thierry" sort="Gorlia, Thierry" uniqKey="Gorlia T" first="Thierry" last="Gorlia">Thierry Gorlia</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>European Organisation for Research and Treatment of Cancer Headquarters, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
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<author><name sortKey="Hoang Xuan, Khe" sort="Hoang Xuan, Khe" uniqKey="Hoang Xuan K" first="Khê" last="Hoang-Xuan">Khê Hoang-Xuan</name>
<affiliation wicri:level="3"><nlm:affiliation>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Brandes, Alba A" sort="Brandes, Alba A" uniqKey="Brandes A" first="Alba A" last="Brandes">Alba A. Brandes</name>
<affiliation wicri:level="1"><nlm:affiliation>AUSL-IRCCS Scienze Neurologiche, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>AUSL-IRCCS Scienze Neurologiche, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
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<author><name sortKey="Kantor, Guy" sort="Kantor, Guy" uniqKey="Kantor G" first="Guy" last="Kantor">Guy Kantor</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Bergonié, Comprehensive Cancer Center and University Bordeaux Segalen, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Bergonié, Comprehensive Cancer Center and University Bordeaux Segalen, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
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<author><name sortKey="Taphoorn, Martin J B" sort="Taphoorn, Martin J B" uniqKey="Taphoorn M" first="Martin J B" last="Taphoorn">Martin J B. Taphoorn</name>
<affiliation wicri:level="3"><nlm:affiliation>Medical Center Haaglanden, The Hague, Netherlands; Leiden University Center, Leiden, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Medical Center Haaglanden, The Hague, Netherlands; Leiden University Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<author><name sortKey="Hassel, Mohamed Ben" sort="Hassel, Mohamed Ben" uniqKey="Hassel M" first="Mohamed Ben" last="Hassel">Mohamed Ben Hassel</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Eugène Marquis, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Eugène Marquis, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartmann, Christian" sort="Hartmann, Christian" uniqKey="Hartmann C" first="Christian" last="Hartmann">Christian Hartmann</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany; Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany; Institute of Pathology, Medizinische Hochschule Hannover, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
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</author>
<author><name sortKey="Ryan, Gail" sort="Ryan, Gail" uniqKey="Ryan G" first="Gail" last="Ryan">Gail Ryan</name>
<affiliation wicri:level="1"><nlm:affiliation>Peter MacCallum Cancer Center, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Peter MacCallum Cancer Center, Melbourne, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Capper, David" sort="Capper, David" uniqKey="Capper D" first="David" last="Capper">David Capper</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kros, Johan M" sort="Kros, Johan M" uniqKey="Kros J" first="Johan M" last="Kros">Johan M. Kros</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC Cancer Institute University Medical Centre, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kurscheid, Sebastian" sort="Kurscheid, Sebastian" uniqKey="Kurscheid S" first="Sebastian" last="Kurscheid">Sebastian Kurscheid</name>
<affiliation wicri:level="1"><nlm:affiliation>Lausanne University Hospital, Lausanne, Switzerland; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lausanne University Hospital, Lausanne, Switzerland; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT</wicri:regionArea>
<wicri:noRegion>ACT</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wick, Wolfgang" sort="Wick, Wolfgang" uniqKey="Wick W" first="Wolfgang" last="Wick">Wolfgang Wick</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Enting, Roelien" sort="Enting, Roelien" uniqKey="Enting R" first="Roelien" last="Enting">Roelien Enting</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Groningen, Groningen, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
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<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Reni, Michele" sort="Reni, Michele" uniqKey="Reni M" first="Michele" last="Reni">Michele Reni</name>
<affiliation wicri:level="3"><nlm:affiliation>IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thiessen, Brian" sort="Thiessen, Brian" uniqKey="Thiessen B" first="Brian" last="Thiessen">Brian Thiessen</name>
<affiliation wicri:level="1"><nlm:affiliation>BC Cancer Agency, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>BC Cancer Agency, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dhermain, Frederic" sort="Dhermain, Frederic" uniqKey="Dhermain F" first="Frederic" last="Dhermain">Frederic Dhermain</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bromberg, Jacoline E" sort="Bromberg, Jacoline E" uniqKey="Bromberg J" first="Jacoline E" last="Bromberg">Jacoline E. Bromberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC Cancer Institute University Medical Centre, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feuvret, Loic" sort="Feuvret, Loic" uniqKey="Feuvret L" first="Loic" last="Feuvret">Loic Feuvret</name>
<affiliation wicri:level="3"><nlm:affiliation>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reijneveld, Jaap C" sort="Reijneveld, Jaap C" uniqKey="Reijneveld J" first="Jaap C" last="Reijneveld">Jaap C. Reijneveld</name>
<affiliation wicri:level="3"><nlm:affiliation>VU University Medical Center and Academic Medical Center, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>VU University Medical Center and Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chinot, Olivier" sort="Chinot, Olivier" uniqKey="Chinot O" first="Olivier" last="Chinot">Olivier Chinot</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix Marseille, Université, APHM, Hôpital de la Timone, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille, Université, APHM, Hôpital de la Timone, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gijtenbeek, Johanna M M" sort="Gijtenbeek, Johanna M M" uniqKey="Gijtenbeek J" first="Johanna M M" last="Gijtenbeek">Johanna M M. Gijtenbeek</name>
<affiliation wicri:level="3"><nlm:affiliation>Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Medical Center, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rossiter, John P" sort="Rossiter, John P" uniqKey="Rossiter J" first="John P" last="Rossiter">John P. Rossiter</name>
<affiliation wicri:level="1"><nlm:affiliation>Queen's University, Kingston, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Queen's University, Kingston, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dif, Nicolas" sort="Dif, Nicolas" uniqKey="Dif N" first="Nicolas" last="Dif">Nicolas Dif</name>
<affiliation wicri:level="3"><nlm:affiliation>European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>European Organisation for Research and Treatment of Cancer Headquarters, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balana, Carmen" sort="Balana, Carmen" uniqKey="Balana C" first="Carmen" last="Balana">Carmen Balana</name>
<affiliation wicri:level="3"><nlm:affiliation>ICO Badalona Hospital Germans Trias I Pujol, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>ICO Badalona Hospital Germans Trias I Pujol, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bravo Marques, Jose" sort="Bravo Marques, Jose" uniqKey="Bravo Marques J" first="Jose" last="Bravo-Marques">Jose Bravo-Marques</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto Portugues de Oncologia de Lisboa, Lisbon, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Instituto Portugues de Oncologia de Lisboa, Lisbon</wicri:regionArea>
<wicri:noRegion>Lisbon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clement, Paul M" sort="Clement, Paul M" uniqKey="Clement P" first="Paul M" last="Clement">Paul M. Clement</name>
<affiliation wicri:level="1"><nlm:affiliation>KU Leuven, Department of Oncology, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>KU Leuven, Department of Oncology, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marosi, Christine" sort="Marosi, Christine" uniqKey="Marosi C" first="Christine" last="Marosi">Christine Marosi</name>
<affiliation wicri:level="3"><nlm:affiliation>Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzuk Shina, Tzahala" sort="Tzuk Shina, Tzahala" uniqKey="Tzuk Shina T" first="Tzahala" last="Tzuk-Shina">Tzahala Tzuk-Shina</name>
<affiliation wicri:level="1"><nlm:affiliation>Rambam Health Care Campus, Oncology Institute, Haifa, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Rambam Health Care Campus, Oncology Institute, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nordal, Robert A" sort="Nordal, Robert A" uniqKey="Nordal R" first="Robert A" last="Nordal">Robert A. Nordal</name>
<affiliation wicri:level="4"><nlm:affiliation>Tom Baker Cancer Center, University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tom Baker Cancer Center, University of Calgary, Calgary, AB</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rees, Jeremy" sort="Rees, Jeremy" uniqKey="Rees J" first="Jeremy" last="Rees">Jeremy Rees</name>
<affiliation wicri:level="3"><nlm:affiliation>National Hospital for Neurology and Neurosurgery, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Hospital for Neurology and Neurosurgery, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lacombe, Denis" sort="Lacombe, Denis" uniqKey="Lacombe D" first="Denis" last="Lacombe">Denis Lacombe</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Mason, Warren P" sort="Mason, Warren P" uniqKey="Mason W" first="Warren P" last="Mason">Warren P. Mason</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Stupp, Roger" sort="Stupp, Roger" uniqKey="Stupp R" first="Roger" last="Stupp">Roger Stupp</name>
<affiliation wicri:level="1"><nlm:affiliation>Lausanne University Hospital, Lausanne, Switzerland; University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Lausanne University Hospital, Lausanne, Switzerland; University Hospital Zurich, Zurich</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.</title>
<author><name sortKey="Baumert, Brigitta G" sort="Baumert, Brigitta G" uniqKey="Baumert B" first="Brigitta G" last="Baumert">Brigitta G. Baumert</name>
<affiliation wicri:level="3"><nlm:affiliation>Maastricht University Medical Centre and GROW (School for Oncology), Maastricht, Netherlands; MediClin Robert-Janker-Clinic/Clinical Cooperation Unit of Neurooncology, University Bonn Medical Centre, Bonn, Germany. Electronic address: brigitta.baumert@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Maastricht University Medical Centre and GROW (School for Oncology), Maastricht, Netherlands; MediClin Robert-Janker-Clinic/Clinical Cooperation Unit of Neurooncology, University Bonn Medical Centre, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hegi, Monika E" sort="Hegi, Monika E" uniqKey="Hegi M" first="Monika E" last="Hegi">Monika E. Hegi</name>
<affiliation wicri:level="3"><nlm:affiliation>Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Lausanne University Hospital, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Den Bent, Martin J" sort="Van Den Bent, Martin J" uniqKey="Van Den Bent M" first="Martin J" last="Van Den Bent">Martin J. Van Den Bent</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC Cancer Institute University Medical Centre, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gorlia, Thierry" sort="Gorlia, Thierry" uniqKey="Gorlia T" first="Thierry" last="Gorlia">Thierry Gorlia</name>
<affiliation wicri:level="3"><nlm:affiliation>European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>European Organisation for Research and Treatment of Cancer Headquarters, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoang Xuan, Khe" sort="Hoang Xuan, Khe" uniqKey="Hoang Xuan K" first="Khê" last="Hoang-Xuan">Khê Hoang-Xuan</name>
<affiliation wicri:level="3"><nlm:affiliation>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brandes, Alba A" sort="Brandes, Alba A" uniqKey="Brandes A" first="Alba A" last="Brandes">Alba A. Brandes</name>
<affiliation wicri:level="1"><nlm:affiliation>AUSL-IRCCS Scienze Neurologiche, Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>AUSL-IRCCS Scienze Neurologiche, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kantor, Guy" sort="Kantor, Guy" uniqKey="Kantor G" first="Guy" last="Kantor">Guy Kantor</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Bergonié, Comprehensive Cancer Center and University Bordeaux Segalen, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Bergonié, Comprehensive Cancer Center and University Bordeaux Segalen, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taphoorn, Martin J B" sort="Taphoorn, Martin J B" uniqKey="Taphoorn M" first="Martin J B" last="Taphoorn">Martin J B. Taphoorn</name>
<affiliation wicri:level="3"><nlm:affiliation>Medical Center Haaglanden, The Hague, Netherlands; Leiden University Center, Leiden, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Medical Center Haaglanden, The Hague, Netherlands; Leiden University Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Hassel, Mohamed Ben" sort="Hassel, Mohamed Ben" uniqKey="Hassel M" first="Mohamed Ben" last="Hassel">Mohamed Ben Hassel</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Eugène Marquis, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Eugène Marquis, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartmann, Christian" sort="Hartmann, Christian" uniqKey="Hartmann C" first="Christian" last="Hartmann">Christian Hartmann</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany; Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany; Institute of Pathology, Medizinische Hochschule Hannover, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ryan, Gail" sort="Ryan, Gail" uniqKey="Ryan G" first="Gail" last="Ryan">Gail Ryan</name>
<affiliation wicri:level="1"><nlm:affiliation>Peter MacCallum Cancer Center, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Peter MacCallum Cancer Center, Melbourne, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Capper, David" sort="Capper, David" uniqKey="Capper D" first="David" last="Capper">David Capper</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kros, Johan M" sort="Kros, Johan M" uniqKey="Kros J" first="Johan M" last="Kros">Johan M. Kros</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC Cancer Institute University Medical Centre, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kurscheid, Sebastian" sort="Kurscheid, Sebastian" uniqKey="Kurscheid S" first="Sebastian" last="Kurscheid">Sebastian Kurscheid</name>
<affiliation wicri:level="1"><nlm:affiliation>Lausanne University Hospital, Lausanne, Switzerland; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lausanne University Hospital, Lausanne, Switzerland; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT</wicri:regionArea>
<wicri:noRegion>ACT</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wick, Wolfgang" sort="Wick, Wolfgang" uniqKey="Wick W" first="Wolfgang" last="Wick">Wolfgang Wick</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Enting, Roelien" sort="Enting, Roelien" uniqKey="Enting R" first="Roelien" last="Enting">Roelien Enting</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Groningen, Groningen, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Reni, Michele" sort="Reni, Michele" uniqKey="Reni M" first="Michele" last="Reni">Michele Reni</name>
<affiliation wicri:level="3"><nlm:affiliation>IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thiessen, Brian" sort="Thiessen, Brian" uniqKey="Thiessen B" first="Brian" last="Thiessen">Brian Thiessen</name>
<affiliation wicri:level="1"><nlm:affiliation>BC Cancer Agency, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>BC Cancer Agency, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dhermain, Frederic" sort="Dhermain, Frederic" uniqKey="Dhermain F" first="Frederic" last="Dhermain">Frederic Dhermain</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bromberg, Jacoline E" sort="Bromberg, Jacoline E" uniqKey="Bromberg J" first="Jacoline E" last="Bromberg">Jacoline E. Bromberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC Cancer Institute University Medical Centre, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feuvret, Loic" sort="Feuvret, Loic" uniqKey="Feuvret L" first="Loic" last="Feuvret">Loic Feuvret</name>
<affiliation wicri:level="3"><nlm:affiliation>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reijneveld, Jaap C" sort="Reijneveld, Jaap C" uniqKey="Reijneveld J" first="Jaap C" last="Reijneveld">Jaap C. Reijneveld</name>
<affiliation wicri:level="3"><nlm:affiliation>VU University Medical Center and Academic Medical Center, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>VU University Medical Center and Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chinot, Olivier" sort="Chinot, Olivier" uniqKey="Chinot O" first="Olivier" last="Chinot">Olivier Chinot</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix Marseille, Université, APHM, Hôpital de la Timone, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille, Université, APHM, Hôpital de la Timone, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gijtenbeek, Johanna M M" sort="Gijtenbeek, Johanna M M" uniqKey="Gijtenbeek J" first="Johanna M M" last="Gijtenbeek">Johanna M M. Gijtenbeek</name>
<affiliation wicri:level="3"><nlm:affiliation>Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Medical Center, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rossiter, John P" sort="Rossiter, John P" uniqKey="Rossiter J" first="John P" last="Rossiter">John P. Rossiter</name>
<affiliation wicri:level="1"><nlm:affiliation>Queen's University, Kingston, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Queen's University, Kingston, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dif, Nicolas" sort="Dif, Nicolas" uniqKey="Dif N" first="Nicolas" last="Dif">Nicolas Dif</name>
<affiliation wicri:level="3"><nlm:affiliation>European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>European Organisation for Research and Treatment of Cancer Headquarters, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balana, Carmen" sort="Balana, Carmen" uniqKey="Balana C" first="Carmen" last="Balana">Carmen Balana</name>
<affiliation wicri:level="3"><nlm:affiliation>ICO Badalona Hospital Germans Trias I Pujol, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>ICO Badalona Hospital Germans Trias I Pujol, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bravo Marques, Jose" sort="Bravo Marques, Jose" uniqKey="Bravo Marques J" first="Jose" last="Bravo-Marques">Jose Bravo-Marques</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto Portugues de Oncologia de Lisboa, Lisbon, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Instituto Portugues de Oncologia de Lisboa, Lisbon</wicri:regionArea>
<wicri:noRegion>Lisbon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clement, Paul M" sort="Clement, Paul M" uniqKey="Clement P" first="Paul M" last="Clement">Paul M. Clement</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>KU Leuven, Department of Oncology, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marosi, Christine" sort="Marosi, Christine" uniqKey="Marosi C" first="Christine" last="Marosi">Christine Marosi</name>
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<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzuk Shina, Tzahala" sort="Tzuk Shina, Tzahala" uniqKey="Tzuk Shina T" first="Tzahala" last="Tzuk-Shina">Tzahala Tzuk-Shina</name>
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<country xml:lang="fr">Israël</country>
<wicri:regionArea>Rambam Health Care Campus, Oncology Institute, Haifa</wicri:regionArea>
<wicri:noRegion>Haifa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nordal, Robert A" sort="Nordal, Robert A" uniqKey="Nordal R" first="Robert A" last="Nordal">Robert A. Nordal</name>
<affiliation wicri:level="4"><nlm:affiliation>Tom Baker Cancer Center, University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tom Baker Cancer Center, University of Calgary, Calgary, AB</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rees, Jeremy" sort="Rees, Jeremy" uniqKey="Rees J" first="Jeremy" last="Rees">Jeremy Rees</name>
<affiliation wicri:level="3"><nlm:affiliation>National Hospital for Neurology and Neurosurgery, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Hospital for Neurology and Neurosurgery, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lacombe, Denis" sort="Lacombe, Denis" uniqKey="Lacombe D" first="Denis" last="Lacombe">Denis Lacombe</name>
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea>European Organisation for Research and Treatment of Cancer Headquarters, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mason, Warren P" sort="Mason, Warren P" uniqKey="Mason W" first="Warren P" last="Mason">Warren P. Mason</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Princess Margaret Hospital, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
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<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Lausanne University Hospital, Lausanne, Switzerland; University Hospital Zurich, Zurich</wicri:regionArea>
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<series><title level="j">The Lancet. Oncology</title>
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<front><div type="abstract" xml:lang="en">Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27686946</PMID>
<DateCreated><Year>2016</Year>
<Month>09</Month>
<Day>30</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>05</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-5488</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>11</Issue>
<PubDate><Year>2016</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>The Lancet. Oncology</Title>
<ISOAbbreviation>Lancet Oncol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.</ArticleTitle>
<Pagination><MedlinePgn>1521-1532</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1470-2045(16)30313-8</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/S1470-2045(16)30313-8</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">For this randomised, open-label, phase 3 intergroup study (EORTC 22033-26033), undertaken in 78 clinical centres in 19 countries, we included patients aged 18 years or older who had a low-grade (WHO grade II) glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma) with at least one high-risk feature (aged >40 years, progressive disease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HIV infection, chronic hepatitis B or C virus infection, or any condition that could interfere with oral drug administration. Eligible patients were randomly assigned (1:1) to receive either conformal radiotherapy (up to 50·4 Gy; 28 doses of 1·8 Gy once daily, 5 days per week for up to 6·5 weeks) or dose-dense oral temozolomide (75 mg/m(2) once daily for 21 days, repeated every 28 days [one cycle], for a maximum of 12 cycles). Random treatment allocation was done online by a minimisation technique with prospective stratification by institution, 1p deletion (absent vs present vs undetermined), contrast enhancement (yes vs no), age (<40 vs ≥40 years), and WHO performance status (0 vs ≥1). Patients, treating physicians, and researchers were aware of the assigned intervention. A planned analysis was done after 216 progression events occurred. Our primary clinical endpoint was progression-free survival, analysed by intention-to-treat; secondary outcomes were overall survival, adverse events, neurocognitive function (will be reported separately), health-related quality of life and neurological function (reported separately), and correlative analyses of progression-free survival by molecular markers (1p/19q co-deletion, MGMT promoter methylation status, and IDH1/IDH2 mutations). This trial is closed to accrual but continuing for follow-up, and is registered at the European Trials Registry, EudraCT 2004-002714-11, and at ClinicalTrials.gov, NCT00182819.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">Between Sept 23, 2005, and March 26, 2010, 707 patients were registered for the study. Between Dec 6, 2005, and Dec 21, 2012, we randomly assigned 477 patients to receive either radiotherapy (n=240) or temozolomide chemotherapy (n=237). At a median follow-up of 48 months (IQR 31-56), median progression-free survival was 39 months (95% CI 35-44) in the temozolomide group and 46 months (40-56) in the radiotherapy group (unadjusted hazard ratio [HR] 1·16, 95% CI 0·9-1·5, p=0·22). Median overall survival has not been reached. Exploratory analyses in 318 molecularly-defined patients confirmed the significantly different prognosis for progression-free survival in the three recently defined molecular low-grade glioma subgroups (IDHmt, with or without 1p/19q co-deletion [IDHmt/codel], or IDH wild type [IDHwt]; p=0·013). Patients with IDHmt/non-codel tumours treated with radiotherapy had a longer progression-free survival than those treated with temozolomide (HR 1·86 [95% CI 1·21-2·87], log-rank p=0·0043), whereas there were no significant treatment-dependent differences in progression-free survival for patients with IDHmt/codel and IDHwt tumours. Grade 3-4 haematological adverse events occurred in 32 (14%) of 236 patients treated with temozolomide and in one (<1%) of 228 patients treated with radiotherapy, and grade 3-4 infections occurred in eight (3%) of 236 patients treated with temozolomide and in two (1%) of 228 patients treated with radiotherapy. Moderate to severe fatigue was recorded in eight (3%) patients in the radiotherapy group (grade 2) and 16 (7%) in the temozolomide group. 119 (25%) of all 477 patients had died at database lock. Four patients died due to treatment-related causes: two in the temozolomide group and two in the radiotherapy group.</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Overall, there was no significant difference in progression-free survival in patients with low-grade glioma when treated with either radiotherapy alone or temozolomide chemotherapy alone. Further data maturation is needed for overall survival analyses and evaluation of the full predictive effects of different molecular subtypes for future individualised treatment choices.</AbstractText>
<AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Merck Sharpe & Dohme-Merck & Co, Canadian Cancer Society, Swiss Cancer League, UK National Institutes of Health, Australian National Health and Medical Research Council, US National Cancer Institute, European Organisation for Research and Treatment of Cancer Cancer Research Fund.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baumert</LastName>
<ForeName>Brigitta G</ForeName>
<Initials>BG</Initials>
<AffiliationInfo><Affiliation>Maastricht University Medical Centre and GROW (School for Oncology), Maastricht, Netherlands; MediClin Robert-Janker-Clinic/Clinical Cooperation Unit of Neurooncology, University Bonn Medical Centre, Bonn, Germany. Electronic address: brigitta.baumert@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hegi</LastName>
<ForeName>Monika E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Lausanne University Hospital, Lausanne, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van den Bent</LastName>
<ForeName>Martin J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>von Deimling</LastName>
<ForeName>Andreas</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gorlia</LastName>
<ForeName>Thierry</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hoang-Xuan</LastName>
<ForeName>Khê</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brandes</LastName>
<ForeName>Alba A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>AUSL-IRCCS Scienze Neurologiche, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kantor</LastName>
<ForeName>Guy</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Institut Bergonié, Comprehensive Cancer Center and University Bordeaux Segalen, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Taphoorn</LastName>
<ForeName>Martin J B</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Medical Center Haaglanden, The Hague, Netherlands; Leiden University Center, Leiden, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hassel</LastName>
<ForeName>Mohamed Ben</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>Centre Eugène Marquis, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hartmann</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany; Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ryan</LastName>
<ForeName>Gail</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Peter MacCallum Cancer Center, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Capper</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kros</LastName>
<ForeName>Johan M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kurscheid</LastName>
<ForeName>Sebastian</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Lausanne University Hospital, Lausanne, Switzerland; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wick</LastName>
<ForeName>Wolfgang</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>University of Heidelberg and CCU Neuropathology German Cancer Research Centre, Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Enting</LastName>
<ForeName>Roelien</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>University of Groningen, Groningen, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reni</LastName>
<ForeName>Michele</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Thiessen</LastName>
<ForeName>Brian</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>BC Cancer Agency, Vancouver, BC, Canada.</Affiliation>
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<ForeName>Frederic</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Institut Gustave Roussy, Villejuif, France.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Jacoline E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Erasmus MC Cancer Institute University Medical Centre, Rotterdam, Netherlands.</Affiliation>
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<ForeName>Loic</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>APHP, Pitié-Salpêtrière, Hospital and UPMC, Sorbonne Universités, Paris, France.</Affiliation>
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</Author>
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<ForeName>Jaap C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>VU University Medical Center and Academic Medical Center, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chinot</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Aix Marseille, Université, APHM, Hôpital de la Timone, Marseille, France.</Affiliation>
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<ForeName>Johanna M M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Radboud University Medical Center, Nijmegen, Netherlands.</Affiliation>
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<Author ValidYN="Y"><LastName>Rossiter</LastName>
<ForeName>John P</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Queen's University, Kingston, ON, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Dif</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium.</Affiliation>
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<Author ValidYN="Y"><LastName>Balana</LastName>
<ForeName>Carmen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>ICO Badalona Hospital Germans Trias I Pujol, Barcelona, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Bravo-Marques</LastName>
<ForeName>Jose</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Instituto Portugues de Oncologia de Lisboa, Lisbon, Portugal.</Affiliation>
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<Author ValidYN="Y"><LastName>Clement</LastName>
<ForeName>Paul M</ForeName>
<Initials>PM</Initials>
<AffiliationInfo><Affiliation>KU Leuven, Department of Oncology, Leuven, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marosi</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tzuk-Shina</LastName>
<ForeName>Tzahala</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Rambam Health Care Campus, Oncology Institute, Haifa, Israel.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nordal</LastName>
<ForeName>Robert A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Tom Baker Cancer Center, University of Calgary, Calgary, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rees</LastName>
<ForeName>Jeremy</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>National Hospital for Neurology and Neurosurgery, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lacombe</LastName>
<ForeName>Denis</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mason</LastName>
<ForeName>Warren P</ForeName>
<Initials>WP</Initials>
<AffiliationInfo><Affiliation>Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stupp</LastName>
<ForeName>Roger</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Lausanne University Hospital, Lausanne, Switzerland; University Hospital Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT00182819</AccessionNumber>
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<GrantList CompleteYN="Y"><Grant><GrantID>U10 CA011488</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>09</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Lancet Oncol</MedlineTA>
<NlmUniqueID>100957246</NlmUniqueID>
<ISSNLinking>1470-2045</ISSNLinking>
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<NameOfSubstance UI="D003606">Dacarbazine</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.1.1.41</RegistryNumber>
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<Chemical><RegistryNumber>EC 1.1.1.41</RegistryNumber>
<NameOfSubstance UI="C538784">isocitrate dehydrogenase 2, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.1.1.42.</RegistryNumber>
<NameOfSubstance UI="C543588">IDH1 protein, human</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="C047246">temozolomide</NameOfSubstance>
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<li>Autriche</li>
<li>Belgique</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Israël</li>
<li>Italie</li>
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<li>Aquitaine</li>
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<li>District de Cologne</li>
<li>District de Karlsruhe</li>
<li>Grand Londres</li>
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<li>Gueldre</li>
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<li>Hollande-Septentrionale</li>
<li>Lombardie</li>
<li>Nouvelle-Aquitaine</li>
<li>Ontario</li>
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<li>Rhénanie-du-Nord-Westphalie</li>
<li>Région Bretagne</li>
<li>Région de Bruxelles-Capitale</li>
<li>Vienne (Autriche)</li>
<li>Île-de-France</li>
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<li>Barcelone</li>
<li>Bonn</li>
<li>Bordeaux</li>
<li>Bruxelles</li>
<li>Calgary</li>
<li>Groningue</li>
<li>Groningue (ville)</li>
<li>Hanovre</li>
<li>Heidelberg</li>
<li>Lausanne</li>
<li>Leyde</li>
<li>Londres</li>
<li>Marseille</li>
<li>Milan</li>
<li>Nimègue</li>
<li>Paris</li>
<li>Rennes</li>
<li>Rotterdam</li>
<li>Toronto</li>
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<li>Université de Groningue</li>
<li>Université de Toronto</li>
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<name sortKey="Feuvret, Loic" sort="Feuvret, Loic" uniqKey="Feuvret L" first="Loic" last="Feuvret">Loic Feuvret</name>
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<name sortKey="Nordal, Robert A" sort="Nordal, Robert A" uniqKey="Nordal R" first="Robert A" last="Nordal">Robert A. Nordal</name>
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<country name="Espagne"><region name="Catalogne"><name sortKey="Balana, Carmen" sort="Balana, Carmen" uniqKey="Balana C" first="Carmen" last="Balana">Carmen Balana</name>
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<country name="Portugal"><noRegion><name sortKey="Bravo Marques, Jose" sort="Bravo Marques, Jose" uniqKey="Bravo Marques J" first="Jose" last="Bravo-Marques">Jose Bravo-Marques</name>
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<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Marosi, Christine" sort="Marosi, Christine" uniqKey="Marosi C" first="Christine" last="Marosi">Christine Marosi</name>
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<country name="Israël"><noRegion><name sortKey="Tzuk Shina, Tzahala" sort="Tzuk Shina, Tzahala" uniqKey="Tzuk Shina T" first="Tzahala" last="Tzuk-Shina">Tzahala Tzuk-Shina</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rees, Jeremy" sort="Rees, Jeremy" uniqKey="Rees J" first="Jeremy" last="Rees">Jeremy Rees</name>
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   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
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   |clé=     pubmed:27686946
   |texte=   Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
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This area was generated with Dilib version V0.6.33.
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	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.

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