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The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice.

Identifieur interne : 001535 ( PubMed/Checkpoint ); précédent : 001534; suivant : 001536

The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice.

Auteurs : Nabil El Massri [Australie] ; Daniel M. Johnstone [Australie] ; Cassandra L. Peoples [Australie] ; Cécile Moro [France] ; Florian Reinhart [France] ; Napoleon Torres [France] ; Jonathan Stone [Australie] ; Alim-Louis Benabid [France] ; John Mitrofanis [Australie]

Source :

The International journal of neuroscience [ 1563-5279 ] ; 2016.

RBID : pubmed:25469453

Descripteurs français

KwdFr :
- 1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine (administration et posologie), Animaux, Astrocytes (anatomopathologie), Astrocytes (effets des radiations), Gliose (anatomopathologie), Gliose (radiothérapie), Intoxication au MPTP (anatomopathologie), Intoxication au MPTP (radiothérapie), Mâle, Neurones dopaminergiques (), Neurones dopaminergiques (effets des radiations), Noyau caudé (anatomopathologie), Noyau caudé (effets des radiations), Numération cellulaire, Pars compacta (anatomopathologie), Pars compacta (effets des radiations), Protéines de tissu nerveux (analyse), Putamen (anatomopathologie), Putamen (effets des radiations), Rayons infrarouges (usage thérapeutique), Relation dose-effet des médicaments, Relation dose-effet des radiations, Souris, Souris de lignée BALB C, Survie cellulaire (effets des radiations), Syndromes parkinsoniens (anatomopathologie), Syndromes parkinsoniens (radiothérapie), Tyrosine 3-monooxygenase (analyse).
MESH :
- administration et posologie : 1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine.
- analyse : Protéines de tissu nerveux, Tyrosine 3-monooxygenase.
- anatomopathologie : Astrocytes, Gliose, Intoxication au MPTP, Noyau caudé, Pars compacta, Putamen, Syndromes parkinsoniens.
- effets des radiations : Astrocytes, Neurones dopaminergiques, Noyau caudé, Pars compacta, Putamen, Survie cellulaire.
- radiothérapie : Gliose, Intoxication au MPTP, Syndromes parkinsoniens.
- usage thérapeutique : Rayons infrarouges.
- Animaux, Mâle, Neurones dopaminergiques, Numération cellulaire, Relation dose-effet des médicaments, Relation dose-effet des radiations, Souris, Souris de lignée BALB C.

English descriptors

KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (administration & dosage), Animals, Astrocytes (pathology), Astrocytes (radiation effects), Caudate Nucleus (pathology), Caudate Nucleus (radiation effects), Cell Count, Cell Survival (radiation effects), Dopaminergic Neurons (drug effects), Dopaminergic Neurons (radiation effects), Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Gliosis (pathology), Gliosis (radiotherapy), Infrared Rays (therapeutic use), MPTP Poisoning (pathology), MPTP Poisoning (radiotherapy), Male, Mice, Mice, Inbred BALB C, Nerve Tissue Proteins (analysis), Parkinsonian Disorders (pathology), Parkinsonian Disorders (radiotherapy), Pars Compacta (pathology), Pars Compacta (radiation effects), Putamen (pathology), Putamen (radiation effects), Tyrosine 3-Monooxygenase (analysis).
MESH :
- chemical , administration & dosage : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemical , analysis : Nerve Tissue Proteins, Tyrosine 3-Monooxygenase.
- drug effects : Dopaminergic Neurons.
- pathology : Astrocytes, Caudate Nucleus, Gliosis, MPTP Poisoning, Parkinsonian Disorders, Pars Compacta, Putamen.
- radiation effects : Astrocytes, Caudate Nucleus, Cell Survival, Dopaminergic Neurons, Pars Compacta, Putamen.
- radiotherapy : Gliosis, MPTP Poisoning, Parkinsonian Disorders.
- therapeutic use : Infrared Rays.
- Animals, Cell Count, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Male, Mice, Mice, Inbred BALB C.

Abstract

We have used the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model to explore whether (i) the neuroprotective effect of near infrared light (NIr) treatment in the SNc is dose-dependent and (ii) the relationship between tyrosine hydroxylase (TH)+ terminal density and glial cells in the caudate-putamen complex (CPu). Mice received MPTP injections (50 mg/kg) and 2 J/cm2 NIr dose with either 2 d or 7 d survival period. In another series, with a longer 14 d survival period, mice had a stronger MPTP regime (100 mg/kg) and either 2 J/cm2 or 4 J/cm2 NIr dose. Brains were processed for routine immunohistochemistry and cell counts were made using stereology. Our findings were that in the 2 d series, no change in SNc TH+ cell number was evident after any treatment. In the 7 d series however, MPTP insult resulted in ∼45% reduction in TH+ cell number; after NIr (2 J/cm2) treatment, many cells were protected from the toxic insult. In the 14 d series, MPTP induced a similar reduction in TH+ cell number. NIr mitigated the loss of TH+ cells, but only at the higher dose of 4 J/cm2; the lower dose of 2 J/cm2 had no neuroprotective effect in this series. The higher dose of NIr, unlike the lower dose, also mitigated the MPTP- induced increase in CPu astrocytes after 14 d; these changes were independent of TH+ terminal density, of which, did not vary across the different experimental groups. In summary, we showed that neuroprotection by NIr irradiation in MPTP-treated mice was dose-dependent; with increasing MPTP toxicity, higher doses of NIr were required to protect cells and reduce astrogliosis.

DOI: 10.3109/00207454.2014.994063
PubMed: 25469453

Affiliations:

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<term>Animals</term>
<term>Astrocytes (pathology)</term>
<term>Astrocytes (radiation effects)</term>
<term>Caudate Nucleus (pathology)</term>
<term>Caudate Nucleus (radiation effects)</term>
<term>Cell Count</term>
<term>Cell Survival (radiation effects)</term>
<term>Dopaminergic Neurons (drug effects)</term>
<term>Dopaminergic Neurons (radiation effects)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Dose-Response Relationship, Radiation</term>
<term>Gliosis (pathology)</term>
<term>Gliosis (radiotherapy)</term>
<term>Infrared Rays (therapeutic use)</term>
<term>MPTP Poisoning (pathology)</term>
<term>MPTP Poisoning (radiotherapy)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Nerve Tissue Proteins (analysis)</term>
<term>Parkinsonian Disorders (pathology)</term>
<term>Parkinsonian Disorders (radiotherapy)</term>
<term>Pars Compacta (pathology)</term>
<term>Pars Compacta (radiation effects)</term>
<term>Putamen (pathology)</term>
<term>Putamen (radiation effects)</term>
<term>Tyrosine 3-Monooxygenase (analysis)</term>
</keywords>
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<term>Animaux</term>
<term>Astrocytes (anatomopathologie)</term>
<term>Astrocytes (effets des radiations)</term>
<term>Gliose (anatomopathologie)</term>
<term>Gliose (radiothérapie)</term>
<term>Intoxication au MPTP (anatomopathologie)</term>
<term>Intoxication au MPTP (radiothérapie)</term>
<term>Mâle</term>
<term>Neurones dopaminergiques ()</term>
<term>Neurones dopaminergiques (effets des radiations)</term>
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<term>Rayons infrarouges (usage thérapeutique)</term>
<term>Relation dose-effet des médicaments</term>
<term>Relation dose-effet des radiations</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Survie cellulaire (effets des radiations)</term>
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<term>Syndromes parkinsoniens (radiothérapie)</term>
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<term>Tyrosine 3-Monooxygenase</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine</term>
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<term>Tyrosine 3-monooxygenase</term>
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<term>Gliose</term>
<term>Intoxication au MPTP</term>
<term>Noyau caudé</term>
<term>Pars compacta</term>
<term>Putamen</term>
<term>Syndromes parkinsoniens</term>
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<keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Astrocytes</term>
<term>Neurones dopaminergiques</term>
<term>Noyau caudé</term>
<term>Pars compacta</term>
<term>Putamen</term>
<term>Survie cellulaire</term>
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<term>Caudate Nucleus</term>
<term>Gliosis</term>
<term>MPTP Poisoning</term>
<term>Parkinsonian Disorders</term>
<term>Pars Compacta</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Astrocytes</term>
<term>Caudate Nucleus</term>
<term>Cell Survival</term>
<term>Dopaminergic Neurons</term>
<term>Pars Compacta</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Gliosis</term>
<term>MPTP Poisoning</term>
<term>Parkinsonian Disorders</term>
</keywords>
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<term>Intoxication au MPTP</term>
<term>Syndromes parkinsoniens</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Infrared Rays</term>
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</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Count</term>
<term>Dose-Response Relationship, Drug</term>
<term>Dose-Response Relationship, Radiation</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Mâle</term>
<term>Neurones dopaminergiques</term>
<term>Numération cellulaire</term>
<term>Relation dose-effet des médicaments</term>
<term>Relation dose-effet des radiations</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
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<front><div type="abstract" xml:lang="en">We have used the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model to explore whether (i) the neuroprotective effect of near infrared light (NIr) treatment in the SNc is dose-dependent and (ii) the relationship between tyrosine hydroxylase (TH)+ terminal density and glial cells in the caudate-putamen complex (CPu). Mice received MPTP injections (50 mg/kg) and 2 J/cm2 NIr dose with either 2 d or 7 d survival period. In another series, with a longer 14 d survival period, mice had a stronger MPTP regime (100 mg/kg) and either 2 J/cm2 or 4 J/cm2 NIr dose. Brains were processed for routine immunohistochemistry and cell counts were made using stereology. Our findings were that in the 2 d series, no change in SNc TH+ cell number was evident after any treatment. In the 7 d series however, MPTP insult resulted in ∼45% reduction in TH+ cell number; after NIr (2 J/cm2) treatment, many cells were protected from the toxic insult. In the 14 d series, MPTP induced a similar reduction in TH+ cell number. NIr mitigated the loss of TH+ cells, but only at the higher dose of 4 J/cm2; the lower dose of 2 J/cm2 had no neuroprotective effect in this series. The higher dose of NIr, unlike the lower dose, also mitigated the MPTP- induced increase in CPu astrocytes after 14 d; these changes were independent of TH+ terminal density, of which, did not vary across the different experimental groups. In summary, we showed that neuroprotection by NIr irradiation in MPTP-treated mice was dose-dependent; with increasing MPTP toxicity, higher doses of NIr were required to protect cells and reduce astrogliosis.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25469453</PMID>
<DateCreated><Year>2015</Year>
<Month>12</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>09</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>12</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1563-5279</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>126</Volume>
<Issue>1</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>The International journal of neuroscience</Title>
<ISOAbbreviation>Int. J. Neurosci.</ISOAbbreviation>
</Journal>
<ArticleTitle>The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice.</ArticleTitle>
<Pagination><MedlinePgn>76-87</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3109/00207454.2014.994063</ELocationID>
<Abstract><AbstractText>We have used the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model to explore whether (i) the neuroprotective effect of near infrared light (NIr) treatment in the SNc is dose-dependent and (ii) the relationship between tyrosine hydroxylase (TH)+ terminal density and glial cells in the caudate-putamen complex (CPu). Mice received MPTP injections (50 mg/kg) and 2 J/cm2 NIr dose with either 2 d or 7 d survival period. In another series, with a longer 14 d survival period, mice had a stronger MPTP regime (100 mg/kg) and either 2 J/cm2 or 4 J/cm2 NIr dose. Brains were processed for routine immunohistochemistry and cell counts were made using stereology. Our findings were that in the 2 d series, no change in SNc TH+ cell number was evident after any treatment. In the 7 d series however, MPTP insult resulted in ∼45% reduction in TH+ cell number; after NIr (2 J/cm2) treatment, many cells were protected from the toxic insult. In the 14 d series, MPTP induced a similar reduction in TH+ cell number. NIr mitigated the loss of TH+ cells, but only at the higher dose of 4 J/cm2; the lower dose of 2 J/cm2 had no neuroprotective effect in this series. The higher dose of NIr, unlike the lower dose, also mitigated the MPTP- induced increase in CPu astrocytes after 14 d; these changes were independent of TH+ terminal density, of which, did not vary across the different experimental groups. In summary, we showed that neuroprotection by NIr irradiation in MPTP-treated mice was dose-dependent; with increasing MPTP toxicity, higher doses of NIr were required to protect cells and reduce astrogliosis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>El Massri</LastName>
<ForeName>Nabil</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>a Department of Anatomy F13, University of Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnstone</LastName>
<ForeName>Daniel M</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>b Department of Physiology F13, University of Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peoples</LastName>
<ForeName>Cassandra L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>a Department of Anatomy F13, University of Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moro</LastName>
<ForeName>Cécile</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reinhart</LastName>
<ForeName>Florian</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Torres</LastName>
<ForeName>Napoleon</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stone</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>b Department of Physiology F13, University of Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Benabid</LastName>
<ForeName>Alim-Louis</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mitrofanis</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>a Department of Anatomy F13, University of Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>01</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Int J Neurosci</MedlineTA>
<NlmUniqueID>0270707</NlmUniqueID>
<ISSNLinking>0020-7454</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009419">Nerve Tissue Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9P21XSP91P</RegistryNumber>
<NameOfSubstance UI="D015632">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.14.16.2</RegistryNumber>
<NameOfSubstance UI="D014446">Tyrosine 3-Monooxygenase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D015632" MajorTopicYN="N">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001253" MajorTopicYN="N">Astrocytes</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002421" MajorTopicYN="N">Caudate Nucleus</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059290" MajorTopicYN="N">Dopaminergic Neurons</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004307" MajorTopicYN="N">Dose-Response Relationship, Radiation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005911" MajorTopicYN="N">Gliosis</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007259" MajorTopicYN="N">Infrared Rays</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020267" MajorTopicYN="N">MPTP Poisoning</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009419" MajorTopicYN="N">Nerve Tissue Proteins</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065842" MajorTopicYN="N">Pars Compacta</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011699" MajorTopicYN="N">Putamen</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014446" MajorTopicYN="N">Tyrosine 3-Monooxygenase</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">neuroprotection</Keyword>
<Keyword MajorTopicYN="N">substantia nigra</Keyword>
<Keyword MajorTopicYN="N">tyrosine hydroxylase</Keyword>
</KeywordList>
</MedlineCitation>
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<Month>12</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>12</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>9</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25469453</ArticleId>
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</pubmed>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Nouvelle-Galles du Sud</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Grenoble</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="El Massri, Nabil" sort="El Massri, Nabil" uniqKey="El Massri N" first="Nabil" last="El Massri">Nabil El Massri</name>
</region>
<name sortKey="Johnstone, Daniel M" sort="Johnstone, Daniel M" uniqKey="Johnstone D" first="Daniel M" last="Johnstone">Daniel M. Johnstone</name>
<name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name>
<name sortKey="Peoples, Cassandra L" sort="Peoples, Cassandra L" uniqKey="Peoples C" first="Cassandra L" last="Peoples">Cassandra L. Peoples</name>
<name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name>
</region>
<name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name>
<name sortKey="Reinhart, Florian" sort="Reinhart, Florian" uniqKey="Reinhart F" first="Florian" last="Reinhart">Florian Reinhart</name>
<name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name>
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</tree>
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The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice.

The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice.

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