α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors.
Identifieur interne : 001367 ( PubMed/Checkpoint ); précédent : 001366; suivant : 001368α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors.
Auteurs : Pablo J. Enriori [Australie] ; Weiyi Chen [Australie] ; Maria C. Garcia-Rudaz [Australie] ; Bernadette E. Grayson [États-Unis] ; Anne E. Evans [États-Unis] ; Sarah M. Comstock [États-Unis] ; Ursel Gebhardt [Allemagne] ; Hermann L. Müller [Allemagne] ; Thomas Reinehr [Allemagne] ; Belinda A. Henry [Australie] ; Russell D. Brown [Australie] ; Clinton R. Bruce [Australie] ; Stephanie E. Simonds [Australie] ; Sara A. Litwak [Australie] ; Sean L. Mcgee [Australie] ; Serge Luquet [France] ; Sarah Martinez [France] ; Martin Jastroch [Allemagne] ; Matthias H. Tschöp [Allemagne] ; Matthew J. Watt [Australie] ; Iain J. Clarke [Australie] ; Christian L. Roth [États-Unis] ; Kevin L. Grove [États-Unis] ; Michael A. Cowley [Australie]Source :
- Molecular metabolism [ 2212-8778 ] ; 2016.
Abstract
Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a role in glucose homeostasis and tested the hypothesis that the pituitary is able to sense a physiological increase in circulating glucose and responds by secreting α-MSH.
DOI: 10.1016/j.molmet.2016.07.009
PubMed: 27688995
Affiliations:
- Allemagne, Australie, France, États-Unis
- Bavière, District de Haute-Bavière, Oregon, Washington (État)
- Munich
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Enriori</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Weiyi" sort="Chen, Weiyi" uniqKey="Chen W" first="Weiyi" last="Chen">Weiyi Chen</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Garcia Rudaz, Maria C" sort="Garcia Rudaz, Maria C" uniqKey="Garcia Rudaz M" first="Maria C" last="Garcia-Rudaz">Maria C. Garcia-Rudaz</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Grayson, Bernadette E" sort="Grayson, Bernadette E" uniqKey="Grayson B" first="Bernadette E" last="Grayson">Bernadette E. Grayson</name><affiliation wicri:level="2"><nlm:affiliation>Division Neuroscience, Oregon Health and Science University, Oregon, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division Neuroscience, Oregon Health and Science University, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Evans, Anne E" sort="Evans, Anne E" uniqKey="Evans A" first="Anne E" last="Evans">Anne E. Evans</name><affiliation wicri:level="2"><nlm:affiliation>Division Neuroscience, Oregon Health and Science University, Oregon, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division Neuroscience, Oregon Health and Science University, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Comstock, Sarah M" sort="Comstock, Sarah M" uniqKey="Comstock S" first="Sarah M" last="Comstock">Sarah M. Comstock</name><affiliation wicri:level="2"><nlm:affiliation>Division Neuroscience, Oregon Health and Science University, Oregon, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division Neuroscience, Oregon Health and Science University, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Gebhardt, Ursel" sort="Gebhardt, Ursel" uniqKey="Gebhardt U" first="Ursel" last="Gebhardt">Ursel Gebhardt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Vestische Children Hospital Datteln, University of Witten/Herdecke, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, Vestische Children Hospital Datteln, University of Witten/Herdecke</wicri:regionArea><wicri:noRegion>University of Witten/Herdecke</wicri:noRegion><wicri:noRegion>University of Witten/Herdecke</wicri:noRegion><wicri:noRegion>University of Witten/Herdecke</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Hermann L" sort="Muller, Hermann L" uniqKey="Muller H" first="Hermann L" last="Müller">Hermann L. Müller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Vestische Children Hospital Datteln, University of Witten/Herdecke, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, Vestische Children Hospital Datteln, University of Witten/Herdecke</wicri:regionArea><wicri:noRegion>University of Witten/Herdecke</wicri:noRegion><wicri:noRegion>University of Witten/Herdecke</wicri:noRegion><wicri:noRegion>University of Witten/Herdecke</wicri:noRegion></affiliation></author><author><name sortKey="Reinehr, Thomas" sort="Reinehr, Thomas" uniqKey="Reinehr T" first="Thomas" last="Reinehr">Thomas Reinehr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Klinikum Oldenburg GmbH, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, Klinikum Oldenburg GmbH</wicri:regionArea><wicri:noRegion>Klinikum Oldenburg GmbH</wicri:noRegion><wicri:noRegion>Klinikum Oldenburg GmbH</wicri:noRegion><wicri:noRegion>Klinikum Oldenburg GmbH</wicri:noRegion></affiliation></author><author><name sortKey="Henry, Belinda A" sort="Henry, Belinda A" uniqKey="Henry B" first="Belinda A" last="Henry">Belinda A. Henry</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Russell D" sort="Brown, Russell D" uniqKey="Brown R" first="Russell D" last="Brown">Russell D. Brown</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Bruce, Clinton R" sort="Bruce, Clinton R" uniqKey="Bruce C" first="Clinton R" last="Bruce">Clinton R. Bruce</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Simonds, Stephanie E" sort="Simonds, Stephanie E" uniqKey="Simonds S" first="Stephanie E" last="Simonds">Stephanie E. Simonds</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Litwak, Sara A" sort="Litwak, Sara A" uniqKey="Litwak S" first="Sara A" last="Litwak">Sara A. Litwak</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Mcgee, Sean L" sort="Mcgee, Sean L" uniqKey="Mcgee S" first="Sean L" last="Mcgee">Sean L. Mcgee</name><affiliation wicri:level="1"><nlm:affiliation>Metabolic Research Unit, School of Medicine, Deakin University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Metabolic Research Unit, School of Medicine, Deakin University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Luquet, Serge" sort="Luquet, Serge" uniqKey="Luquet S" first="Serge" last="Luquet">Serge Luquet</name><affiliation wicri:level="1"><nlm:affiliation>Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris</wicri:regionArea><wicri:noRegion>75205 Paris</wicri:noRegion><wicri:noRegion>75205 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Martinez, Sarah" sort="Martinez, Sarah" uniqKey="Martinez S" first="Sarah" last="Martinez">Sarah Martinez</name><affiliation wicri:level="1"><nlm:affiliation>Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris</wicri:regionArea><wicri:noRegion>75205 Paris</wicri:noRegion><wicri:noRegion>75205 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Jastroch, Martin" sort="Jastroch, Martin" uniqKey="Jastroch M" first="Martin" last="Jastroch">Martin Jastroch</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg & Division of Metabolic Diseases, Technische Universität, München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg & Division of Metabolic Diseases, Technische Universität, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Tschop, Matthias H" sort="Tschop, Matthias H" uniqKey="Tschop M" first="Matthias H" last="Tschöp">Matthias H. Tschöp</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg & Division of Metabolic Diseases, Technische Universität, München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg & Division of Metabolic Diseases, Technische Universität, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Watt, Matthew J" sort="Watt, Matthew J" uniqKey="Watt M" first="Matthew J" last="Watt">Matthew J. Watt</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Iain J" sort="Clarke, Iain J" uniqKey="Clarke I" first="Iain J" last="Clarke">Iain J. Clarke</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Roth, Christian L" sort="Roth, Christian L" uniqKey="Roth C" first="Christian L" last="Roth">Christian L. Roth</name><affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Seattle Children's Hospital Research Institute, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Seattle Children's Hospital Research Institute, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Grove, Kevin L" sort="Grove, Kevin L" uniqKey="Grove K" first="Kevin L" last="Grove">Kevin L. Grove</name><affiliation wicri:level="2"><nlm:affiliation>Division Neuroscience, Oregon Health and Science University, Oregon, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division Neuroscience, Oregon Health and Science University, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Cowley, Michael A" sort="Cowley, Michael A" uniqKey="Cowley M" first="Michael A" last="Cowley">Michael A. Cowley</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular metabolism</title><idno type="ISSN">2212-8778</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a role in glucose homeostasis and tested the hypothesis that the pituitary is able to sense a physiological increase in circulating glucose and responds by secreting α-MSH.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27688995</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>30</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2212-8778</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>10</Issue><PubDate><Year>2016</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Molecular metabolism</Title><ISOAbbreviation>Mol Metab</ISOAbbreviation></Journal><ArticleTitle>α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors.</ArticleTitle><Pagination><MedlinePgn>807-22</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.molmet.2016.07.009</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a role in glucose homeostasis and tested the hypothesis that the pituitary is able to sense a physiological increase in circulating glucose and responds by secreting α-MSH.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We established glucose-stimulated α-MSH secretion using humans, non-human primates, and mouse models. Continuous α-MSH infusions were performed during glucose tolerance tests and hyperinsulinemic-euglycemic clamps to evaluate the systemic effect of α-MSH in glucose regulation. Complementary ex vivo and in vitro techniques were employed to delineate the direct action of α-MSH via the melanocortin 5 receptor (MC5R)-PKA axis in skeletal muscles. Combined treatment of non-selective/selective phosphodiesterase inhibitor and α-MSH was adopted to restore glucose tolerance in obese mice.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Here we demonstrate that pituitary secretion of α-MSH is increased by glucose. Peripheral α-MSH increases temperature in skeletal muscles, acts directly on soleus and gastrocnemius muscles to significantly increase glucose uptake, and enhances whole-body glucose clearance via the activation of muscle MC5R and protein kinase A. These actions are absent in obese mice, accompanied by a blunting of α-MSH-induced cAMP levels in skeletal muscles of obese mice. Both selective and non-selective phosphodiesterase inhibition restores α-MSH induced skeletal muscle glucose uptake and improves glucose disposal in obese mice.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These data describe a novel endocrine circuit that modulates glucose homeostasis by pituitary α-MSH, which increases muscle glucose uptake and thermogenesis through the activation of a MC5R-PKA-pathway, which is disrupted in obesity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Enriori</LastName><ForeName>Pablo J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Weiyi</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garcia-Rudaz</LastName><ForeName>Maria C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grayson</LastName><ForeName>Bernadette E</ForeName><Initials>BE</Initials><AffiliationInfo><Affiliation>Division Neuroscience, Oregon Health and Science University, Oregon, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evans</LastName><ForeName>Anne E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Division Neuroscience, Oregon Health and Science University, Oregon, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Comstock</LastName><ForeName>Sarah M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Division Neuroscience, Oregon Health and Science University, Oregon, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gebhardt</LastName><ForeName>Ursel</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Vestische Children Hospital Datteln, University of Witten/Herdecke, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Hermann L</ForeName><Initials>HL</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Vestische Children Hospital Datteln, University of Witten/Herdecke, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reinehr</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Klinikum Oldenburg GmbH, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henry</LastName><ForeName>Belinda A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>Russell D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruce</LastName><ForeName>Clinton R</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonds</LastName><ForeName>Stephanie E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Litwak</LastName><ForeName>Sara A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McGee</LastName><ForeName>Sean L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Metabolic Research Unit, School of Medicine, Deakin University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luquet</LastName><ForeName>Serge</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jastroch</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg & Division of Metabolic Diseases, Technische Universität, München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tschöp</LastName><ForeName>Matthias H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg & Division of Metabolic Diseases, Technische Universität, München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watt</LastName><ForeName>Matthew J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clarke</LastName><ForeName>Iain J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash University, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roth</LastName><ForeName>Christian L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Division of Endocrinology, Seattle Children's Hospital Research Institute, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grove</LastName><ForeName>Kevin L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Division Neuroscience, Oregon Health and Science University, Oregon, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cowley</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Biomedical Discovery Institute/Department of Physiology, Monash 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RefType="Cites"><RefSource>Endocrinology. 2013 Apr;154(4):1444-53</RefSource><PMID Version="1">23471217</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Glucose homeostasis</Keyword><Keyword MajorTopicYN="N">MC5R</Keyword><Keyword MajorTopicYN="N">PKA</Keyword><Keyword MajorTopicYN="N">Pituitary</Keyword><Keyword MajorTopicYN="N">Skeletal muscles</Keyword><Keyword MajorTopicYN="N">α-MSH</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>07</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27688995</ArticleId><ArticleId IdType="pmc">PMC5034615</ArticleId><ArticleId IdType="doi">10.1016/j.molmet.2016.07.009</ArticleId><ArticleId IdType="pii">S2212-8778(16)30102-8</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Oregon</li><li>Washington (État)</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Enriori, Pablo J" sort="Enriori, Pablo J" uniqKey="Enriori P" first="Pablo J" last="Enriori">Pablo J. Enriori</name></noRegion><name sortKey="Brown, Russell D" sort="Brown, Russell D" uniqKey="Brown R" first="Russell D" last="Brown">Russell D. Brown</name><name sortKey="Bruce, Clinton R" sort="Bruce, Clinton R" uniqKey="Bruce C" first="Clinton R" last="Bruce">Clinton R. Bruce</name><name sortKey="Chen, Weiyi" sort="Chen, Weiyi" uniqKey="Chen W" first="Weiyi" last="Chen">Weiyi Chen</name><name sortKey="Clarke, Iain J" sort="Clarke, Iain J" uniqKey="Clarke I" first="Iain J" last="Clarke">Iain J. Clarke</name><name sortKey="Cowley, Michael A" sort="Cowley, Michael A" uniqKey="Cowley M" first="Michael A" last="Cowley">Michael A. Cowley</name><name sortKey="Garcia Rudaz, Maria C" sort="Garcia Rudaz, Maria C" uniqKey="Garcia Rudaz M" first="Maria C" last="Garcia-Rudaz">Maria C. Garcia-Rudaz</name><name sortKey="Henry, Belinda A" sort="Henry, Belinda A" uniqKey="Henry B" first="Belinda A" last="Henry">Belinda A. Henry</name><name sortKey="Litwak, Sara A" sort="Litwak, Sara A" uniqKey="Litwak S" first="Sara A" last="Litwak">Sara A. Litwak</name><name sortKey="Mcgee, Sean L" sort="Mcgee, Sean L" uniqKey="Mcgee S" first="Sean L" last="Mcgee">Sean L. Mcgee</name><name sortKey="Simonds, Stephanie E" sort="Simonds, Stephanie E" uniqKey="Simonds S" first="Stephanie E" last="Simonds">Stephanie E. Simonds</name><name sortKey="Watt, Matthew J" sort="Watt, Matthew J" uniqKey="Watt M" first="Matthew J" last="Watt">Matthew J. Watt</name></country><country name="États-Unis"><region name="Oregon"><name sortKey="Grayson, Bernadette E" sort="Grayson, Bernadette E" uniqKey="Grayson B" first="Bernadette E" last="Grayson">Bernadette E. Grayson</name></region><name sortKey="Comstock, Sarah M" sort="Comstock, Sarah M" uniqKey="Comstock S" first="Sarah M" last="Comstock">Sarah M. Comstock</name><name sortKey="Evans, Anne E" sort="Evans, Anne E" uniqKey="Evans A" first="Anne E" last="Evans">Anne E. Evans</name><name sortKey="Grove, Kevin L" sort="Grove, Kevin L" uniqKey="Grove K" first="Kevin L" last="Grove">Kevin L. Grove</name><name sortKey="Roth, Christian L" sort="Roth, Christian L" uniqKey="Roth C" first="Christian L" last="Roth">Christian L. Roth</name></country><country name="Allemagne"><noRegion><name sortKey="Gebhardt, Ursel" sort="Gebhardt, Ursel" uniqKey="Gebhardt U" first="Ursel" last="Gebhardt">Ursel Gebhardt</name></noRegion><name sortKey="Jastroch, Martin" sort="Jastroch, Martin" uniqKey="Jastroch M" first="Martin" last="Jastroch">Martin Jastroch</name><name sortKey="Muller, Hermann L" sort="Muller, Hermann L" uniqKey="Muller H" first="Hermann L" last="Müller">Hermann L. Müller</name><name sortKey="Reinehr, Thomas" sort="Reinehr, Thomas" uniqKey="Reinehr T" first="Thomas" last="Reinehr">Thomas Reinehr</name><name sortKey="Tschop, Matthias H" sort="Tschop, Matthias H" uniqKey="Tschop M" first="Matthias H" last="Tschöp">Matthias H. Tschöp</name></country><country name="France"><noRegion><name sortKey="Luquet, Serge" sort="Luquet, Serge" uniqKey="Luquet S" first="Serge" last="Luquet">Serge Luquet</name></noRegion><name sortKey="Martinez, Sarah" sort="Martinez, Sarah" uniqKey="Martinez S" first="Sarah" last="Martinez">Sarah Martinez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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