A perspective on the contribution of animal models to the pharmacological treatment of posttraumatic stress disorder.
Identifieur interne : 001296 ( PubMed/Checkpoint ); précédent : 001295; suivant : 001297A perspective on the contribution of animal models to the pharmacological treatment of posttraumatic stress disorder.
Auteurs : Valerie Bertaina-Anglade [France] ; Susan M. O'Connor [Australie] ; Emile Andriambeloson [France]Source :
- Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists [ 1440-1665 ] ; 2017.
Abstract
Posttraumatic stress disorder (PTSD) is a prevalent, chronic, disabling disorder that may develop following exposure to a traumatic event. This review summarizes currently used animal models of PTSD and their potential role in the development of better therapeutics. Heterogeneity is one of the main characteristics of PTSD with the consequence that many pharmacological approaches are used to relieve symptoms of PTSD. To address the translational properties of the animal models, we discuss the types of stressors used, the rodent correlates of human PTSD (DSM-5) symptoms, and the efficacy of approved, recommended and off-label drugs used to treat PTSD in 'PTSD-animals'.
DOI: 10.1177/1039856217716288
PubMed: 28747120
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O'Connor</name><affiliation wicri:level="1"><nlm:affiliation>Vice President, Neuroscience Research, Bionomics, Thebarton, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Vice President, Neuroscience Research, Bionomics, Thebarton, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Andriambeloson, Emile" sort="Andriambeloson, Emile" uniqKey="Andriambeloson E" first="Emile" last="Andriambeloson">Emile Andriambeloson</name><affiliation wicri:level="1"><nlm:affiliation>Head of Research, Neurofit SAS, Illkirch, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Head of Research, Neurofit SAS, Illkirch</wicri:regionArea><wicri:noRegion>Illkirch</wicri:noRegion><wicri:noRegion>Illkirch</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28747120</idno><idno type="pmid">28747120</idno><idno type="doi">10.1177/1039856217716288</idno><idno type="wicri:Area/PubMed/Corpus">000811</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000811</idno><idno type="wicri:Area/PubMed/Curation">000808</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000808</idno><idno type="wicri:Area/PubMed/Checkpoint">000808</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000808</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A perspective on the contribution of animal models to the pharmacological treatment of posttraumatic stress disorder.</title><author><name sortKey="Bertaina Anglade, Valerie" sort="Bertaina Anglade, Valerie" uniqKey="Bertaina Anglade V" first="Valerie" last="Bertaina-Anglade">Valerie Bertaina-Anglade</name><affiliation wicri:level="3"><nlm:affiliation>Senior Scientist, Translational Neuroscience, Biotrial, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Senior Scientist, Translational Neuroscience, Biotrial, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="O Connor, Susan M" sort="O Connor, Susan M" uniqKey="O Connor S" first="Susan M" last="O'Connor">Susan M. O'Connor</name><affiliation wicri:level="1"><nlm:affiliation>Vice President, Neuroscience Research, Bionomics, Thebarton, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Vice President, Neuroscience Research, Bionomics, Thebarton, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Andriambeloson, Emile" sort="Andriambeloson, Emile" uniqKey="Andriambeloson E" first="Emile" last="Andriambeloson">Emile Andriambeloson</name><affiliation wicri:level="1"><nlm:affiliation>Head of Research, Neurofit SAS, Illkirch, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Head of Research, Neurofit SAS, Illkirch</wicri:regionArea><wicri:noRegion>Illkirch</wicri:noRegion><wicri:noRegion>Illkirch</wicri:noRegion></affiliation></author></analytic><series><title level="j">Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists</title><idno type="eISSN">1440-1665</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Posttraumatic stress disorder (PTSD) is a prevalent, chronic, disabling disorder that may develop following exposure to a traumatic event. This review summarizes currently used animal models of PTSD and their potential role in the development of better therapeutics. Heterogeneity is one of the main characteristics of PTSD with the consequence that many pharmacological approaches are used to relieve symptoms of PTSD. To address the translational properties of the animal models, we discuss the types of stressors used, the rodent correlates of human PTSD (DSM-5) symptoms, and the efficacy of approved, recommended and off-label drugs used to treat PTSD in 'PTSD-animals'.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28747120</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>27</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1440-1665</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists</Title><ISOAbbreviation>Australas Psychiatry</ISOAbbreviation></Journal><ArticleTitle>A perspective on the contribution of animal models to the pharmacological treatment of posttraumatic stress disorder.</ArticleTitle><Pagination><MedlinePgn>342-347</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/1039856217716288</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Posttraumatic stress disorder (PTSD) is a prevalent, chronic, disabling disorder that may develop following exposure to a traumatic event. This review summarizes currently used animal models of PTSD and their potential role in the development of better therapeutics. Heterogeneity is one of the main characteristics of PTSD with the consequence that many pharmacological approaches are used to relieve symptoms of PTSD. To address the translational properties of the animal models, we discuss the types of stressors used, the rodent correlates of human PTSD (DSM-5) symptoms, and the efficacy of approved, recommended and off-label drugs used to treat PTSD in 'PTSD-animals'.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Currently available animal models reproduce most PTSD symptoms and are validated by existing therapeutics. However, novel therapeutics are needed for this disorder as not one drug alleviates all symptoms and many have side effects that lead to non-compliance among PTSD patients. The true translational power of animal models of PTSD will only be demonstrated when new therapeutics acting through novel mechanisms become available for clinical practice.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bertaina-Anglade</LastName><ForeName>Valerie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Senior Scientist, Translational Neuroscience, Biotrial, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Connor</LastName><ForeName>Susan M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Vice President, Neuroscience Research, Bionomics, Thebarton, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andriambeloson</LastName><ForeName>Emile</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Head of Research, Neurofit SAS, Illkirch, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Australas Psychiatry</MedlineTA><NlmUniqueID>9613603</NlmUniqueID><ISSNLinking>1039-8562</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">animal models</Keyword><Keyword MajorTopicYN="N">posttraumatic stress disorder</Keyword><Keyword MajorTopicYN="N">therapeutics</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28747120</ArticleId><ArticleId IdType="doi">10.1177/1039856217716288</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Région Bretagne</li></region><settlement><li>Rennes</li></settlement></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Bertaina Anglade, Valerie" sort="Bertaina Anglade, Valerie" uniqKey="Bertaina Anglade V" first="Valerie" last="Bertaina-Anglade">Valerie Bertaina-Anglade</name></region><name sortKey="Andriambeloson, Emile" sort="Andriambeloson, Emile" uniqKey="Andriambeloson E" first="Emile" last="Andriambeloson">Emile Andriambeloson</name></country><country name="Australie"><noRegion><name sortKey="O Connor, Susan M" sort="O Connor, Susan M" uniqKey="O Connor S" first="Susan M" last="O'Connor">Susan M. 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