Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis.
Identifieur interne : 001033 ( PubMed/Checkpoint ); précédent : 001032; suivant : 001034Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis.
Auteurs : Anne Tournadre [France] ; Bruno Pereira [France] ; Fréderic Dutheil [France] ; Charlotte Giraud [France] ; Daniel Courteix [France] ; Vincent Sapin [France] ; Thomas Frayssac [France] ; Sylvain Mathieu [France] ; Sandrine Malochet-Guinamand [France] ; Martin Soubrier [France]Source :
- Journal of cachexia, sarcopenia and muscle [ 2190-6009 ] ; 2017.
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and could thus improve cardiovascular risk, but their effects on body composition and metabolic profile need to be clarified. We investigated the effects of tocilizumab (TCZ), a humanized anti-interleukin 6 receptor antibody, on body composition and metabolic profile in patients treated for RA.
DOI: 10.1002/jcsm.12189
PubMed: 28316139
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first="Anne" last="Tournadre">Anne Tournadre</name><affiliation wicri:level="3"><nlm:affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Pereira, Bruno" sort="Pereira, Bruno" uniqKey="Pereira B" first="Bruno" last="Pereira">Bruno Pereira</name><affiliation wicri:level="3"><nlm:affiliation>Biostatistics Unit (DRCI), CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biostatistics Unit (DRCI), CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Fréderic" last="Dutheil">Fréderic Dutheil</name><affiliation wicri:level="3"><nlm:affiliation>Department of Preventive and Occupational Medicine, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Preventive and Occupational Medicine, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Giraud, Charlotte" sort="Giraud, Charlotte" uniqKey="Giraud C" first="Charlotte" last="Giraud">Charlotte Giraud</name><affiliation wicri:level="3"><nlm:affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions EA3533, University Clermont Auvergne, CNRS LaPSCo, Physiological and Psychosocial Stress, 24 Avenue des Landais, 63171, Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions EA3533, University Clermont Auvergne, CNRS LaPSCo, Physiological and Psychosocial Stress, 24 Avenue des Landais, 63171, Aubière</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Aubière</settlement></placeName></affiliation></author><author><name sortKey="Sapin, Vincent" sort="Sapin, Vincent" uniqKey="Sapin V" first="Vincent" last="Sapin">Vincent Sapin</name><affiliation wicri:level="3"><nlm:affiliation>Biochemistry and Molecular Biology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biochemistry and Molecular Biology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Frayssac, Thomas" sort="Frayssac, Thomas" uniqKey="Frayssac T" first="Thomas" last="Frayssac">Thomas Frayssac</name><affiliation wicri:level="3"><nlm:affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Mathieu, Sylvain" sort="Mathieu, Sylvain" uniqKey="Mathieu S" first="Sylvain" last="Mathieu">Sylvain Mathieu</name><affiliation wicri:level="3"><nlm:affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Malochet Guinamand, Sandrine" sort="Malochet Guinamand, Sandrine" uniqKey="Malochet Guinamand S" first="Sandrine" last="Malochet-Guinamand">Sandrine Malochet-Guinamand</name><affiliation wicri:level="3"><nlm:affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Soubrier, Martin" sort="Soubrier, Martin" uniqKey="Soubrier M" first="Martin" last="Soubrier">Martin Soubrier</name><affiliation wicri:level="3"><nlm:affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of cachexia, sarcopenia and muscle</title><idno type="eISSN">2190-6009</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and could thus improve cardiovascular risk, but their effects on body composition and metabolic profile need to be clarified. We investigated the effects of tocilizumab (TCZ), a humanized anti-interleukin 6 receptor antibody, on body composition and metabolic profile in patients treated for RA.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28316139</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>19</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2190-6009</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of cachexia, sarcopenia and muscle</Title><ISOAbbreviation>J Cachexia Sarcopenia Muscle</ISOAbbreviation></Journal><ArticleTitle>Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis.</ArticleTitle><Pagination><MedlinePgn>639-646</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jcsm.12189</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and could thus improve cardiovascular risk, but their effects on body composition and metabolic profile need to be clarified. We investigated the effects of tocilizumab (TCZ), a humanized anti-interleukin 6 receptor antibody, on body composition and metabolic profile in patients treated for RA.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twenty-one active RA patients treated with TCZ were included in a 1 year open follow-up study. Waist circumference, body mass index, blood pressure, lipid profile, fasting glucose, insulin, serum levels of adipokines and pancreatic/gastrointestinal hormones, and body composition (dual-energy X-ray absorptiometry) were measured at baseline and 6 and 12 months of treatment. At baseline, RA patients were compared with 21 non-RA controls matched for age, sex, body mass index, and metabolic syndrome.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with controls, body composition was altered in RA with a decrease in total and appendicular lean mass, whereas fat composition was not modified. Among RA patients, 28.6% had a skeletal muscle mass index below the cut-off point for sarcopaenia (4.8% of controls). After 1 year of treatment with TCZ, there was a significant weight gain without changes for fat mass. In contrast, an increase in lean mass was observed with a significant gain in appendicular lean mass and skeletal muscle mass index between 6 and 12 months. Distribution of the fat was modified with a decrease in trunk/peripheral fat ratio and an increase in subcutaneous adipose tissue. No changes for waist circumference, blood pressure, fasting glucose, and atherogenic index were observed.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Despite weight gain during treatment with TCZ, no increase in fat but a modification in fat distribution was observed. In contrast, muscle gain suggests that blocking IL-6 might be efficient in treating sarcopaenia associated with RA.</AbstractText><CopyrightInformation>© 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tournadre</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UNH-UMR 1019, INRA, University Clermont Auvergne, 58 rue Montalembert, BP 321, 63009, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pereira</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Biostatistics Unit (DRCI), CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dutheil</LastName><ForeName>Fréderic</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Preventive and Occupational Medicine, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions EA3533, University Clermont Auvergne, CNRS LaPSCo, Physiological and Psychosocial Stress, 24 Avenue des Landais, 63171, Aubière, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Health, Australian Catholic University, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giraud</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Courteix</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions EA3533, University Clermont Auvergne, CNRS LaPSCo, Physiological and Psychosocial Stress, 24 Avenue des Landais, 63171, Aubière, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Health, Australian Catholic University, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sapin</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Biochemistry and Molecular Biology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Clermont Auvergne, EA7281, 28 Place Henri-Dunant, 63001, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frayssac</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathieu</LastName><ForeName>Sylvain</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malochet-Guinamand</LastName><ForeName>Sandrine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soubrier</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Rheumatology Department, CHU Clermont-Ferrand, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UNH-UMR 1019, INRA, University Clermont Auvergne, 58 rue Montalembert, BP 321, 63009, Clermont-Ferrand CEDEX, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Cachexia Sarcopenia Muscle</MedlineTA><NlmUniqueID>101552883</NlmUniqueID><ISSNLinking>2190-5991</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 2010 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RefType="Cites"><RefSource>Arthritis Care Res (Hoboken). 2011 Feb;63(2):195-202</RefSource><PMID Version="1">20890981</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):639-646</RefSource><PMID Version="1">28316139</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cachexia</Keyword><Keyword MajorTopicYN="N">Metabolic change</Keyword><Keyword MajorTopicYN="N">Rheumatoid arthritis</Keyword><Keyword MajorTopicYN="N">Sarcopaenia</Keyword><Keyword MajorTopicYN="N">Tocilizumab</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>12</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28316139</ArticleId><ArticleId IdType="doi">10.1002/jcsm.12189</ArticleId><ArticleId IdType="pmc">PMC5566648</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li></region><settlement><li>Aubière</li><li>Clermont-Ferrand</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Tournadre, Anne" sort="Tournadre, Anne" uniqKey="Tournadre A" first="Anne" last="Tournadre">Anne Tournadre</name></region><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Fréderic" last="Dutheil">Fréderic Dutheil</name><name sortKey="Frayssac, Thomas" sort="Frayssac, Thomas" uniqKey="Frayssac T" first="Thomas" last="Frayssac">Thomas Frayssac</name><name sortKey="Giraud, Charlotte" sort="Giraud, Charlotte" uniqKey="Giraud C" first="Charlotte" last="Giraud">Charlotte Giraud</name><name sortKey="Malochet Guinamand, Sandrine" sort="Malochet Guinamand, Sandrine" uniqKey="Malochet Guinamand S" first="Sandrine" last="Malochet-Guinamand">Sandrine Malochet-Guinamand</name><name sortKey="Mathieu, Sylvain" sort="Mathieu, Sylvain" uniqKey="Mathieu S" first="Sylvain" last="Mathieu">Sylvain Mathieu</name><name sortKey="Pereira, Bruno" sort="Pereira, Bruno" uniqKey="Pereira B" first="Bruno" last="Pereira">Bruno Pereira</name><name sortKey="Sapin, Vincent" sort="Sapin, Vincent" uniqKey="Sapin V" first="Vincent" last="Sapin">Vincent Sapin</name><name sortKey="Soubrier, Martin" sort="Soubrier, Martin" uniqKey="Soubrier M" first="Martin" last="Soubrier">Martin Soubrier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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