Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study.
Identifieur interne : 001020 ( PubMed/Checkpoint ); précédent : 001019; suivant : 001021Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study.
Auteurs : A Y Zhang [Australie] ; I. Judson [Royaume-Uni] ; C. Benson [Royaume-Uni] ; J S Wunder [Canada] ; I. Ray-Coquard [France] ; R J Grimer [Royaume-Uni] ; R. Quek [Singapour] ; E. Wong [Royaume-Uni] ; A B Miah [Royaume-Uni] ; P C Ferguson [Canada] ; A. Dufresne [France] ; J Y H. Teh [Singapour] ; M. Stockler [Australie] ; M H N. Tattersall [Australie]Source :
- British journal of cancer [ 1532-1827 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anthracyclines (effets indésirables), Antinéoplasiques (effets indésirables), Antinéoplasiques alcoylants (effets indésirables), Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Facteurs temps, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Sarcomes (étiologie), Seconde tumeur primitive (étiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs (radiothérapie), Tumeurs (traitement médicamenteux), Tumeurs radio-induites (étiologie), Études rétrospectives.
- MESH :
- effets indésirables : Anthracyclines, Antinéoplasiques, Antinéoplasiques alcoylants.
- radiothérapie : Tumeurs.
- traitement médicamenteux : Tumeurs.
- étiologie : Sarcomes, Seconde tumeur primitive, Tumeurs radio-induites.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Facteurs temps, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Anthracyclines (adverse effects), Antineoplastic Agents (adverse effects), Antineoplastic Agents, Alkylating (adverse effects), Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Neoplasms (drug therapy), Neoplasms (radiotherapy), Neoplasms, Radiation-Induced (etiology), Neoplasms, Second Primary (etiology), Retrospective Studies, Sarcoma (etiology), Time Factors, Young Adult.
- MESH :
- chemical , adverse effects : Anthracyclines, Antineoplastic Agents, Antineoplastic Agents, Alkylating.
- drug therapy : Neoplasms.
- etiology : Neoplasms, Radiation-Induced, Neoplasms, Second Primary, Sarcoma.
- radiotherapy : Neoplasms.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Retrospective Studies, Time Factors, Young Adult.
Abstract
An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.
DOI: 10.1038/bjc.2017.198
PubMed: 28654633
Affiliations:
- Australie, Canada, France, Royaume-Uni, Singapour
- Auvergne-Rhône-Alpes, Nouvelle-Galles du Sud, Rhône-Alpes
- Lyon, Sydney
- Université de Sydney
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:28654633Le document en format XML
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Judson</name><affiliation wicri:level="1"><nlm:affiliation>Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust, London SW3 6JJ</wicri:regionArea><wicri:noRegion>London SW3 6JJ</wicri:noRegion></affiliation></author><author><name sortKey="Benson, C" sort="Benson, C" uniqKey="Benson C" first="C" last="Benson">C. Benson</name><affiliation wicri:level="1"><nlm:affiliation>Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust, London SW3 6JJ</wicri:regionArea><wicri:noRegion>London SW3 6JJ</wicri:noRegion></affiliation></author><author><name sortKey="Wunder, J S" sort="Wunder, J S" uniqKey="Wunder J" first="J S" last="Wunder">J S Wunder</name><affiliation wicri:level="1"><nlm:affiliation>Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, ON M5G 1X5</wicri:regionArea><wicri:noRegion>ON M5G 1X5</wicri:noRegion></affiliation></author><author><name sortKey="Ray Coquard, I" sort="Ray Coquard, I" uniqKey="Ray Coquard I" first="I" last="Ray-Coquard">I. Ray-Coquard</name><affiliation wicri:level="1"><nlm:affiliation>Centre Léon Bérard, University Claude Bernard, Lyon 69100, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Léon Bérard, University Claude Bernard, Lyon 69100</wicri:regionArea><wicri:noRegion>69100</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Grimer, R J" sort="Grimer, R J" uniqKey="Grimer R" first="R J" last="Grimer">R J Grimer</name><affiliation wicri:level="1"><nlm:affiliation>The Royal Orthopaedic Hospital NHS Trust, Birmingham B31 2AP, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Orthopaedic Hospital NHS Trust, Birmingham B31 2AP</wicri:regionArea><wicri:noRegion>Birmingham B31 2AP</wicri:noRegion></affiliation></author><author><name sortKey="Quek, R" sort="Quek, R" uniqKey="Quek R" first="R" last="Quek">R. Quek</name><affiliation wicri:level="1"><nlm:affiliation>National Cancer Centre, Singapore 169610, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National Cancer Centre, Singapore 169610</wicri:regionArea><wicri:noRegion>Singapore 169610</wicri:noRegion></affiliation></author><author><name sortKey="Wong, E" sort="Wong, E" uniqKey="Wong E" first="E" last="Wong">E. Wong</name><affiliation wicri:level="1"><nlm:affiliation>Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust, London SW3 6JJ</wicri:regionArea><wicri:noRegion>London SW3 6JJ</wicri:noRegion></affiliation></author><author><name sortKey="Miah, A B" sort="Miah, A B" uniqKey="Miah A" first="A B" last="Miah">A B Miah</name><affiliation wicri:level="1"><nlm:affiliation>Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust, London SW3 6JJ</wicri:regionArea><wicri:noRegion>London SW3 6JJ</wicri:noRegion></affiliation></author><author><name sortKey="Ferguson, P C" sort="Ferguson, P C" uniqKey="Ferguson P" first="P C" last="Ferguson">P C Ferguson</name><affiliation wicri:level="1"><nlm:affiliation>Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, ON M5G 1X5</wicri:regionArea><wicri:noRegion>ON M5G 1X5</wicri:noRegion></affiliation></author><author><name sortKey="Dufresne, A" sort="Dufresne, A" uniqKey="Dufresne A" first="A" last="Dufresne">A. Dufresne</name><affiliation wicri:level="1"><nlm:affiliation>Centre Léon Bérard, University Claude Bernard, Lyon 69100, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Léon Bérard, University Claude Bernard, Lyon 69100</wicri:regionArea><wicri:noRegion>69100</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Teh, J Y H" sort="Teh, J Y H" uniqKey="Teh J" first="J Y H" last="Teh">J Y H. Teh</name><affiliation wicri:level="1"><nlm:affiliation>National Cancer Centre, Singapore 169610, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National Cancer Centre, Singapore 169610</wicri:regionArea><wicri:noRegion>Singapore 169610</wicri:noRegion></affiliation></author><author><name sortKey="Stockler, M" sort="Stockler, M" uniqKey="Stockler M" first="M" last="Stockler">M. Stockler</name><affiliation wicri:level="1"><nlm:affiliation>Chris O'Brien Lifehouse, Sydney 2050, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Chris O'Brien Lifehouse, Sydney 2050</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Tattersall, M H N" sort="Tattersall, M H N" uniqKey="Tattersall M" first="M H N" last="Tattersall">M H N. Tattersall</name><affiliation wicri:level="4"><nlm:affiliation>The University of Sydney, Sydney 2006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Sydney, Sydney 2006</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></analytic><series><title level="j">British journal of cancer</title><idno type="eISSN">1532-1827</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Anthracyclines (adverse effects)</term><term>Antineoplastic Agents (adverse effects)</term><term>Antineoplastic Agents, Alkylating (adverse effects)</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Neoplasms (drug therapy)</term><term>Neoplasms (radiotherapy)</term><term>Neoplasms, Radiation-Induced (etiology)</term><term>Neoplasms, Second Primary (etiology)</term><term>Retrospective Studies</term><term>Sarcoma (etiology)</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anthracyclines (effets indésirables)</term><term>Antinéoplasiques (effets indésirables)</term><term>Antinéoplasiques alcoylants (effets indésirables)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de l'âge</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Sarcomes (étiologie)</term><term>Seconde tumeur primitive (étiologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs (radiothérapie)</term><term>Tumeurs (traitement médicamenteux)</term><term>Tumeurs radio-induites (étiologie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anthracyclines</term><term>Antineoplastic Agents</term><term>Antineoplastic Agents, Alkylating</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anthracyclines</term><term>Antinéoplasiques</term><term>Antinéoplasiques alcoylants</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Neoplasms, Radiation-Induced</term><term>Neoplasms, Second Primary</term><term>Sarcoma</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Sarcomes</term><term>Seconde tumeur primitive</term><term>Tumeurs radio-induites</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de l'âge</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28654633</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>27</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-1827</ISSN><JournalIssue CitedMedium="Internet"><Volume>117</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Jul</Month><Day>25</Day></PubDate></JournalIssue><Title>British journal of cancer</Title><ISOAbbreviation>Br. J. Cancer</ISOAbbreviation></Journal><ArticleTitle>Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study.</ArticleTitle><Pagination><MedlinePgn>326-331</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/bjc.2017.198</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI: 1.08-1.72; P=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83-2.43; P<0.001) and chemotherapy for the first malignancy (HR 1.61; 95% CI 1.26-2.05; P<0·001) were independently associated with a shorter time to RIS. Anthracyclines and alkylating agents significantly contribute to the effect.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study confirms an association between chemotherapy given for the first malignancy and a shorter time to development of RIS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>A Y</ForeName><Initials>AY</Initials><AffiliationInfo><Affiliation>The University of Sydney, Sydney 2006, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chris O'Brien Lifehouse, Sydney 2050, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Judson</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benson</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wunder</LastName><ForeName>J S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Surgery, University of Toronto, Toronto, ON M5S, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ray-Coquard</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre Léon Bérard, University Claude Bernard, Lyon 69100, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grimer</LastName><ForeName>R J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>The Royal Orthopaedic Hospital NHS Trust, Birmingham B31 2AP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quek</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Cancer Centre, Singapore 169610, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miah</LastName><ForeName>A B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferguson</LastName><ForeName>P C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Surgery, University of Toronto, Toronto, ON M5S, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dufresne</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre Léon Bérard, University Claude Bernard, Lyon 69100, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teh</LastName><ForeName>J Y H</ForeName><Initials>JYH</Initials><AffiliationInfo><Affiliation>National Cancer Centre, Singapore 169610, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stockler</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Chris O'Brien Lifehouse, Sydney 2050, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney 2006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tattersall</LastName><ForeName>M H N</ForeName><Initials>MHN</Initials><AffiliationInfo><Affiliation>The University of Sydney, Sydney 2006, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chris O'Brien Lifehouse, Sydney 2050, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D023361">Validation Studies</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Cancer</MedlineTA><NlmUniqueID>0370635</NlmUniqueID><ISSNLinking>0007-0920</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018943">Anthracyclines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018906">Antineoplastic Agents, Alkylating</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cancer. 1991 Jan 1;67(1):193-201</RefSource><PMID Version="1">1985716</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Surg Oncol. 2005 Mar;12(3):237-45</RefSource><PMID Version="1">15827816</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 1976 Jun;36(6):2065-9</RefSource><PMID Version="1">1268859</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>CA Cancer J Clin. 2012 Jul-Aug;62(4):220-41</RefSource><PMID Version="1">22700443</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2001 Mar 15;19(6):1610-8</RefSource><PMID 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MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018943" MajorTopicYN="N">Anthracyclines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018906" MajorTopicYN="N">Antineoplastic Agents, Alkylating</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000532" MajorTopicYN="N">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009381" MajorTopicYN="N">Neoplasms, Radiation-Induced</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016609" MajorTopicYN="N">Neoplasms, Second Primary</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012509" MajorTopicYN="N">Sarcoma</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>04</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>05</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>06</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2018</Year><Month>07</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28654633</ArticleId><ArticleId IdType="pii">bjc2017198</ArticleId><ArticleId IdType="doi">10.1038/bjc.2017.198</ArticleId><ArticleId IdType="pmc">PMC5537501</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Royaume-Uni</li><li>Singapour</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Galles du Sud</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Zhang, A Y" sort="Zhang, A Y" uniqKey="Zhang A" first="A Y" last="Zhang">A Y Zhang</name></region><name sortKey="Stockler, M" sort="Stockler, M" uniqKey="Stockler M" first="M" last="Stockler">M. Stockler</name><name sortKey="Tattersall, M H N" sort="Tattersall, M H N" uniqKey="Tattersall M" first="M H N" last="Tattersall">M H N. Tattersall</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Judson, I" sort="Judson, I" uniqKey="Judson I" first="I" last="Judson">I. Judson</name></noRegion><name sortKey="Benson, C" sort="Benson, C" uniqKey="Benson C" first="C" last="Benson">C. Benson</name><name sortKey="Grimer, R J" sort="Grimer, R J" uniqKey="Grimer R" first="R J" last="Grimer">R J Grimer</name><name sortKey="Miah, A B" sort="Miah, A B" uniqKey="Miah A" first="A B" last="Miah">A B Miah</name><name sortKey="Wong, E" sort="Wong, E" uniqKey="Wong E" first="E" last="Wong">E. 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