Clinical and genetic predictors of paclitaxel neurotoxicity based on patient- versus clinician-reported incidence and severity of neurotoxicity in the ICON7 trial.
Identifieur interne : 000F97 ( PubMed/Checkpoint ); précédent : 000F96; suivant : 000F98Clinical and genetic predictors of paclitaxel neurotoxicity based on patient- versus clinician-reported incidence and severity of neurotoxicity in the ICON7 trial.
Auteurs : S B Park [Australie] ; J B Kwok [Australie] ; R. Asher [Australie] ; C K Lee [Australie] ; P. Beale [Australie] ; F. Selle [France] ; M. FriedlanderSource :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2017.
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of paclitaxel, with no reliable method to identify at-risk patients. We investigated the incidence and risk factors including genetic polymorphisms associated with the development of CIPN based on clinician and patient reporting of neuropathic symptoms.
DOI: 10.1093/annonc/mdx491
PubMed: 29117336
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Asher</name><affiliation wicri:level="3"><nlm:affiliation>National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>National Health and Medical Research Council Clinical Trials Centre, University of Sydney</wicri:orgArea></affiliation></author><author><name sortKey="Lee, C K" sort="Lee, C K" uniqKey="Lee C" first="C K" last="Lee">C K Lee</name><affiliation wicri:level="3"><nlm:affiliation>National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>National Health and Medical Research Council Clinical Trials Centre, University of Sydney</wicri:orgArea></affiliation></author><author><name sortKey="Beale, P" sort="Beale, P" uniqKey="Beale P" first="P" last="Beale">P. Beale</name><affiliation wicri:level="3"><nlm:affiliation>Concord Cancer Centre, Concord Repatriation General Hospital, Sydney.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>Concord Cancer Centre, Concord Repatriation General Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Selle, F" sort="Selle, F" uniqKey="Selle F" first="F" last="Selle">F. Selle</name><affiliation wicri:level="3"><nlm:affiliation>Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens and Department of Medical Oncology, Alliance For Cancer Research, Hôpital Tenon, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens and Department of Medical Oncology, Alliance For Cancer Research, Hôpital Tenon, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M" last="Friedlander">M. 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Asher</name><affiliation wicri:level="3"><nlm:affiliation>National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>National Health and Medical Research Council Clinical Trials Centre, University of Sydney</wicri:orgArea></affiliation></author><author><name sortKey="Lee, C K" sort="Lee, C K" uniqKey="Lee C" first="C K" last="Lee">C K Lee</name><affiliation wicri:level="3"><nlm:affiliation>National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>National Health and Medical Research Council Clinical Trials Centre, University of Sydney</wicri:orgArea></affiliation></author><author><name sortKey="Beale, P" sort="Beale, P" uniqKey="Beale P" first="P" last="Beale">P. Beale</name><affiliation wicri:level="3"><nlm:affiliation>Concord Cancer Centre, Concord Repatriation General Hospital, Sydney.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>Concord Cancer Centre, Concord Repatriation General Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Selle, F" sort="Selle, F" uniqKey="Selle F" first="F" last="Selle">F. Selle</name><affiliation wicri:level="3"><nlm:affiliation>Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens and Department of Medical Oncology, Alliance For Cancer Research, Hôpital Tenon, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens and Department of Medical Oncology, Alliance For Cancer Research, Hôpital Tenon, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M" last="Friedlander">M. Friedlander</name><affiliation><nlm:affiliation>Prince of Wales Clinical School.</nlm:affiliation><wicri:noCountry code="no comma">Prince of Wales Clinical School.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of paclitaxel, with no reliable method to identify at-risk patients. We investigated the incidence and risk factors including genetic polymorphisms associated with the development of CIPN based on clinician and patient reporting of neuropathic symptoms.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">29117336</PMID><DateCreated><Year>2017</Year><Month>11</Month><Day>08</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1569-8041</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>11</Issue><PubDate><Year>2017</Year><Month>Nov</Month><Day>01</Day></PubDate></JournalIssue><Title>Annals of oncology : official journal of the European Society for Medical Oncology</Title><ISOAbbreviation>Ann. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Clinical and genetic predictors of paclitaxel neurotoxicity based on patient- versus clinician-reported incidence and severity of neurotoxicity in the ICON7 trial.</ArticleTitle><Pagination><MedlinePgn>2733-2740</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/annonc/mdx491</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of paclitaxel, with no reliable method to identify at-risk patients. We investigated the incidence and risk factors including genetic polymorphisms associated with the development of CIPN based on clinician and patient reporting of neuropathic symptoms.</AbstractText><AbstractText Label="Patients and methods" NlmCategory="UNASSIGNED">Risk factors for the development of CIPN were examined in 454 patients treated with paclitaxel/carboplatin from the International Collaboration on Ovarian Neoplasms 7 (ICON7) trial. Neuropathy was graded by clinicians by standard adverse event reporting and by patients utilising OV28 questionnaire. Genetic risk factors were examined by selecting six single nucleotide polymorphisms in genes associated with microtubule function. Risk factors were assessed via dose-to-event cox regression models.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Grade >2 neuropathy was reported by clinicians in 28% of patients, while 67% of patients reported 'quite a bit' or 'very much' tingling or numbness. Agreement between clinicians and patients was poor (κ = 0.236, 95% confidence interval, 0.177-0.296, P < 0.001). Older age, bevacizumab treatment and bowel resection were associated with clinician reported CIPN, while older age and volume of residual disease were associated with patient-reported neuropathy. There were no significant associations between clinician-reported neuropathy or patient-reported neuropathy and TUBB2, CEP72 or individual MAPT or GSK3B SNPs, however MAPT additive polymorphisms were associated with patient-reported neuropathy and GSK3B additive polymorphisms were associated with clinician reported CIPN.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">There was significant discordance between patient- and clinician-reported neurotoxicity. The lack of consensus regarding optimal outcome measures and whose opinion with regard to CIPN takes precedence is a limitation in the investigation of risk factors for CIPN. Care must be taken to select and include patient-reported outcome measures in CIPN assessment to enable accurate identification of genetic and other risk factors for neuropathy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Park</LastName><ForeName>S B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Brain and Mind Centre, Sydney Medical School, University of Sydney, Sydney.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Prince of Wales Clinical School.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwok</LastName><ForeName>J B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Brain and Mind Centre, Sydney Medical School, University of Sydney, Sydney.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neuroscience Research Australia, University of New South Wales, Sydney.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asher</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>C K</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beale</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Concord Cancer Centre, Concord Repatriation General Hospital, Sydney.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sydney Medical School, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Selle</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens and Department of Medical Oncology, Alliance For Cancer Research, Hôpital Tenon, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Friedlander</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Prince of Wales Clinical School.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Oncol</MedlineTA><NlmUniqueID>9007735</NlmUniqueID><ISSNLinking>0923-7534</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">neuropathy</Keyword><Keyword MajorTopicYN="N">neurotoxicity</Keyword><Keyword MajorTopicYN="N">paclitaxel</Keyword><Keyword MajorTopicYN="N">patient-reported outcome</Keyword><Keyword MajorTopicYN="N">polymorphism</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>11</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>11</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29117336</ArticleId><ArticleId IdType="pii">4107380</ArticleId><ArticleId IdType="doi">10.1093/annonc/mdx491</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Sydney</li></settlement></list><tree><noCountry><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M" last="Friedlander">M. Friedlander</name></noCountry><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Park, S B" sort="Park, S B" uniqKey="Park S" first="S B" last="Park">S B Park</name></region><name sortKey="Asher, R" sort="Asher, R" uniqKey="Asher R" first="R" last="Asher">R. Asher</name><name sortKey="Beale, P" sort="Beale, P" uniqKey="Beale P" first="P" last="Beale">P. Beale</name><name sortKey="Kwok, J B" sort="Kwok, J B" uniqKey="Kwok J" first="J B" last="Kwok">J B Kwok</name><name sortKey="Lee, C K" sort="Lee, C K" uniqKey="Lee C" first="C K" last="Lee">C K Lee</name></country><country name="France"><region name="Île-de-France"><name sortKey="Selle, F" sort="Selle, F" uniqKey="Selle F" first="F" last="Selle">F. Selle</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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