Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol.
Identifieur interne : 000F01 ( PubMed/Checkpoint ); précédent : 000F00; suivant : 000F02Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol.
Auteurs : Bindi Borg [Australie] ; Seema Mihrshahi [Australie] ; Mark Griffin [Australie] ; Chhoun Chamnan [Cambodge] ; Arnaud Laillou [Cambodge] ; Frank T. Wieringa [France]Source :
- BMJ open [ 2044-6055 ] ; 2017.
Abstract
The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micronutrient fortified lipid-based nutrient supplement. This food is innovative, in that it uses fish instead of milk as the animal source food. Very few supplementary foods have non-milk animal source foods, and in addition they have not been widely tested. This trial will assess the novel food's acceptability to children and caregivers.
DOI: 10.1136/bmjopen-2017-015958
PubMed: 28882910
Affiliations:
- Australie, Cambodge, France
- Languedoc-Roussillon, Nouvelle-Galles du Sud, Occitanie (région administrative)
- Montpellier, Sydney
- Université de Sydney
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Wieringa</name><affiliation wicri:level="3"><nlm:affiliation>UMR-204 Nutripass, Institut de Recherche pour le Développement, IRD/UM/SupAgro, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR-204 Nutripass, Institut de Recherche pour le Développement, IRD/UM/SupAgro, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author></analytic><series><title level="j">BMJ open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micronutrient fortified lipid-based nutrient supplement. This food is innovative, in that it uses fish instead of milk as the animal source food. Very few supplementary foods have non-milk animal source foods, and in addition they have not been widely tested. This trial will assess the novel food's acceptability to children and caregivers.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28882910</PMID><DateCreated><Year>2017</Year><Month>09</Month><Day>08</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>15</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2044-6055</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>9</Issue><PubDate><Year>2017</Year><Month>Sep</Month><Day>06</Day></PubDate></JournalIssue><Title>BMJ open</Title><ISOAbbreviation>BMJ Open</ISOAbbreviation></Journal><ArticleTitle>Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol.</ArticleTitle><Pagination><MedlinePgn>e015958</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjopen-2017-015958</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micronutrient fortified lipid-based nutrient supplement. This food is innovative, in that it uses fish instead of milk as the animal source food. Very few supplementary foods have non-milk animal source foods, and in addition they have not been widely tested. This trial will assess the novel food's acceptability to children and caregivers.</AbstractText><AbstractText Label="METHODS AND ANALYSIS" NlmCategory="UNASSIGNED">This is a cluster-randomised, incomplete block, 4×4 crossover design with no blinding. It will take place in four sites in a community setting in periurban Phnom Penh. Healthy children aged 9-23 months (n=100) will eat each of four foods for 3 days at a time. The amount they consume will be measured, and at the end of each 3-day set, caregivers will assess how well their child liked the food. After 12 days, caregivers themselves will do a sensory test of the 4 foods and will rank them in terms of preference.</AbstractText><AbstractText Label="ETHICS AND DISSEMINATION" NlmCategory="UNASSIGNED">Ethical clearance was received from the University of Queensland Medical Research Ethics Committee (2014001070) and from Cambodia's National Ethics Committee for Health Research (03/8 NECHR).</AbstractText><AbstractText Label="REGISTRATION" NlmCategory="UNASSIGNED">ClinicalTrials.gov, identifier: LNS-CAMB-INFANTS; NCT02257437. Pre-results.</AbstractText><CopyrightInformation>© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Borg</LastName><ForeName>Bindi</ForeName><Initials>B</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2764-9788</Identifier><AffiliationInfo><Affiliation>School of Public Health, University of Sydney, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mihrshahi</LastName><ForeName>Seema</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>School of Public Health, University of Sydney, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griffin</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>School of Public Health, University of Queensland, Brisbane, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chamnan</LastName><ForeName>Chhoun</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>DFPTQ, Fisheries Administration, Ministry of Agriculture, Forestry and Fisheries, Phnom Penh, Cambodia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laillou</LastName><ForeName>Arnaud</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>UNICEF, Phnom Penh, Cambodia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wieringa</LastName><ForeName>Frank T</ForeName><Initials>FT</Initials><AffiliationInfo><Affiliation>UMR-204 Nutripass, Institut de Recherche pour le Développement, IRD/UM/SupAgro, Montpellier, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>09</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMJ Open</MedlineTA><NlmUniqueID>101552874</NlmUniqueID><ISSNLinking>2044-6055</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Food Nutr Bull. 2009 Sep;30(3 Suppl):S267-342</RefSource><PMID Version="1">19998863</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nutr J. 2013 Aug 15;12 :120</RefSource><PMID Version="1">23945188</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Public Health Action. 2013 Jun 21;3(2):128-35</RefSource><PMID Version="1">26393015</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bull World Health Organ. 2002;80(12):926-32</RefSource><PMID Version="1">12571719</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nutr Rev. 2011 Feb;69(2):116-7; author reply 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Version="1">21415736</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Nutr. 2013 Apr 14;109(7):1230-40</RefSource><PMID Version="1">22856533</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Food Nutr Bull. 2006 Sep;27(3 Suppl):S83-9</RefSource><PMID Version="1">17076214</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Matern Child Nutr. 2008 Apr;4 Suppl 1:24-85</RefSource><PMID Version="1">18289157</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Food Nutr Bull. 2009 Sep;30(3 Suppl):S434-63</RefSource><PMID Version="1">19998866</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Food Nutr Bull. 2014 Jun;35(2 Suppl):S52-6</RefSource><PMID Version="1">25069294</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2013 Aug 3;382(9890):427-451</RefSource><PMID Version="1">23746772</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mycopathologia. 2009 Nov;168(5):257-68</RefSource><PMID Version="1">19693687</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cochrane Database Syst Rev. 2013 Jun 21;(6):CD009584</RefSource><PMID Version="1">23794237</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Public Health. 2013;13 Suppl 3:S22</RefSource><PMID Version="1">24564207</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2013 Aug 3;382(9890):452-477</RefSource><PMID Version="1">23746776</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Pediatr Adolesc Med. 2012 Sep;166(9):842-50</RefSource><PMID Version="1">22801933</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Lipid-based nutrient supplement (LNS)</Keyword><Keyword MajorTopicYN="N">acceptability</Keyword><Keyword MajorTopicYN="N">hedonic scale</Keyword><Keyword MajorTopicYN="N">micronutrient powder</Keyword><Keyword MajorTopicYN="N">ready-to-use supplementary food (RUSF)</Keyword><Keyword MajorTopicYN="N">test feeding</Keyword></KeywordList><CoiStatement>Competing interests: None declared.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28882910</ArticleId><ArticleId IdType="pii">bmjopen-2017-015958</ArticleId><ArticleId IdType="doi">10.1136/bmjopen-2017-015958</ArticleId><ArticleId IdType="pmc">PMC5588973</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Cambodge</li><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Nouvelle-Galles du Sud</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Borg, Bindi" sort="Borg, Bindi" uniqKey="Borg B" first="Bindi" last="Borg">Bindi Borg</name></region><name sortKey="Griffin, Mark" sort="Griffin, Mark" uniqKey="Griffin M" first="Mark" last="Griffin">Mark Griffin</name><name sortKey="Mihrshahi, Seema" sort="Mihrshahi, Seema" uniqKey="Mihrshahi S" first="Seema" last="Mihrshahi">Seema Mihrshahi</name></country><country name="Cambodge"><noRegion><name sortKey="Chamnan, Chhoun" sort="Chamnan, Chhoun" uniqKey="Chamnan C" first="Chhoun" last="Chamnan">Chhoun Chamnan</name></noRegion><name sortKey="Laillou, Arnaud" sort="Laillou, Arnaud" uniqKey="Laillou A" first="Arnaud" last="Laillou">Arnaud Laillou</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Wieringa, Frank T" sort="Wieringa, Frank T" uniqKey="Wieringa F" first="Frank T" last="Wieringa">Frank T. 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