DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.
Identifieur interne : 000E88 ( PubMed/Checkpoint ); précédent : 000E87; suivant : 000E89DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.
Auteurs : Dilys Lam [Australie] ; Marie-Laure Ancelin [France] ; Karen Ritchie [Royaume-Uni] ; Richard Saffery [Australie] ; Joanne Ryan [Australie]Source :
- Psychoneuroendocrinology [ 1873-3360 ] ; 2017.
Abstract
Depression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic regulation of ACE may play an important role in HPA axis (dys)regulation.
DOI: 10.1016/j.psyneuen.2017.11.003
PubMed: 29132028
Affiliations:
- Australie, France, Royaume-Uni
- Languedoc-Roussillon, Occitanie (région administrative), Victoria (État), Écosse
- Melbourne, Montpellier, Édimbourg
- Université de Melbourne
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:29132028Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.</title><author><name sortKey="Lam, Dilys" sort="Lam, Dilys" uniqKey="Lam D" first="Dilys" last="Lam">Dilys Lam</name><affiliation wicri:level="4"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="4"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="4"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia; INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address: joanne.ryan@monash.edu.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia; INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29132028</idno><idno type="pmid">29132028</idno><idno type="doi">10.1016/j.psyneuen.2017.11.003</idno><idno type="wicri:Area/PubMed/Corpus">000132</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000132</idno><idno type="wicri:Area/PubMed/Curation">000132</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000132</idno><idno type="wicri:Area/PubMed/Checkpoint">000132</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000132</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.</title><author><name sortKey="Lam, Dilys" sort="Lam, Dilys" uniqKey="Lam D" first="Dilys" last="Lam">Dilys Lam</name><affiliation wicri:level="4"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="4"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="4"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia; INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address: joanne.ryan@monash.edu.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia; INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Psychoneuroendocrinology</title><idno type="eISSN">1873-3360</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic regulation of ACE may play an important role in HPA axis (dys)regulation.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29132028</PMID><DateCreated><Year>2017</Year><Month>11</Month><Day>13</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3360</ISSN><JournalIssue CitedMedium="Internet"><Volume>88</Volume><PubDate><Year>2017</Year><Month>Nov</Month><Day>08</Day></PubDate></JournalIssue><Title>Psychoneuroendocrinology</Title><ISOAbbreviation>Psychoneuroendocrinology</ISOAbbreviation></Journal><ArticleTitle>DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.</ArticleTitle><Pagination><MedlinePgn>1-8</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0306-4530(17)30621-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.psyneuen.2017.11.003</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Depression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic regulation of ACE may play an important role in HPA axis (dys)regulation.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate ACE promoter methylation as a biomarker of late-life depression, and its association with genetic variation and cortisol secretion.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">The longitudinal general population ESPRIT study is aimed at investigating psychiatric disorders in older persons (n=1863, average age=73). Depression was assessed using the Mini International Neuropsychiatric Interview according to DSM-IV criteria and the Centre for Epidemiologic Studies Depression Scale (CES-D). Genotype information for seven polymorphisms across the ACE gene was also available. Blood and saliva samples collected at baseline and used to extract DNA and measure cortisol, respectively. Sequenom MassARRAY was used to measure promoter DNA methylation of the ACE gene (n=552).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There was no evidence of an association between ACE promoter methylation and depression. However, there was evidence that ACE genetic variants influenced methylation, and modified the association between depression and methylation (Δ at various sites; -2.05% to 1.74%; p=0.019 to 0.039). Multivariate analyses were adjusted for participants' lifestyle, health and medical history. Independent of depression status, ACE methylation was inversely correlated with cortisol levels (r=-0.336, p=0.042).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This study provides evidence that associations between ACE methylation and depression are genotype-dependent, suggesting that the development of reliable depression biomarkers may need to consider methylation levels in combination with underlying genetic variation. ACE methylation may also be a suitable biomarker of cortisol and/or HPA axis activity.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lam</LastName><ForeName>Dilys</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ancelin</LastName><ForeName>Marie-Laure</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritchie</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saffery</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryan</LastName><ForeName>Joanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital & Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia; INSERM, U1061, Neuropsychiatrie, Recherche Clinique et Epidémiologique, Univ. Montpellier, Montpellier, France; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address: joanne.ryan@monash.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>11</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Psychoneuroendocrinology</MedlineTA><NlmUniqueID>7612148</NlmUniqueID><ISSNLinking>0306-4530</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Angiotensin converting enzyme (ACE)</Keyword><Keyword MajorTopicYN="N">Cortisol</Keyword><Keyword MajorTopicYN="N">DNA methylation</Keyword><Keyword MajorTopicYN="N">Depression</Keyword><Keyword MajorTopicYN="N">Epigenetics</Keyword><Keyword MajorTopicYN="N">Genetic variation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>06</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>09</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>11</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>11</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>11</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29132028</ArticleId><ArticleId IdType="pii">S0306-4530(17)30621-2</ArticleId><ArticleId IdType="doi">10.1016/j.psyneuen.2017.11.003</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Victoria (État)</li><li>Écosse</li></region><settlement><li>Melbourne</li><li>Montpellier</li><li>Édimbourg</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Lam, Dilys" sort="Lam, Dilys" uniqKey="Lam D" first="Dilys" last="Lam">Dilys Lam</name></region><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name></region></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E88 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000E88 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:29132028
|texte= DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:29132028" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |