Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review - OMERACT Virtual Special Interest Group.
Identifieur interne : 000E71 ( PubMed/Checkpoint ); précédent : 000E70; suivant : 000E72Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review - OMERACT Virtual Special Interest Group.
Auteurs : Marita Cross [Australie] ; Ludovic Dubouis [Australie] ; Matthieu Mangin [Australie] ; David J. Hunter [Australie] ; Lyn March [Australie] ; Gillian Hawker [Australie] ; Francis Guillemin [Australie]Source :
- The Journal of rheumatology [ 0315-162X ] ; 2017.
Abstract
Beyond the exacerbation of pain in describing a flare in osteoarthritis (OA), patients and health professionals add other elements that deserve to be fully elucidated, such as effusion, swelling, and mobility limitation. To define and conceptualize the construct flare in OA, the objective was to identify the key variables, or symptoms, that worsen, and to clarify how these variables are described in the literature by patients and clinicians.
DOI: 10.3899/jrheum.161107
PubMed: 28668808
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review - OMERACT Virtual Special Interest Group.</title>
<author><name sortKey="Cross, Marita" sort="Cross, Marita" uniqKey="Cross M" first="Marita" last="Cross">Marita Cross</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
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<author><name sortKey="Dubouis, Ludovic" sort="Dubouis, Ludovic" uniqKey="Dubouis L" first="Ludovic" last="Dubouis">Ludovic Dubouis</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
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<author><name sortKey="Mangin, Matthieu" sort="Mangin, Matthieu" uniqKey="Mangin M" first="Matthieu" last="Mangin">Matthieu Mangin</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
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<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
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<author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
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<author><name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillemin, Francis" sort="Guillemin, Francis" uniqKey="Guillemin F" first="Francis" last="Guillemin">Francis Guillemin</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review - OMERACT Virtual Special Interest Group.</title>
<author><name sortKey="Cross, Marita" sort="Cross, Marita" uniqKey="Cross M" first="Marita" last="Cross">Marita Cross</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
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<author><name sortKey="Dubouis, Ludovic" sort="Dubouis, Ludovic" uniqKey="Dubouis L" first="Ludovic" last="Dubouis">Ludovic Dubouis</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
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<author><name sortKey="Mangin, Matthieu" sort="Mangin, Matthieu" uniqKey="Mangin M" first="Matthieu" last="Mangin">Matthieu Mangin</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
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<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillemin, Francis" sort="Guillemin, Francis" uniqKey="Guillemin F" first="Francis" last="Guillemin">Francis Guillemin</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
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<idno type="ISSN">0315-162X</idno>
<imprint><date when="2017" type="published">2017</date>
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<front><div type="abstract" xml:lang="en">Beyond the exacerbation of pain in describing a flare in osteoarthritis (OA), patients and health professionals add other elements that deserve to be fully elucidated, such as effusion, swelling, and mobility limitation. To define and conceptualize the construct flare in OA, the objective was to identify the key variables, or symptoms, that worsen, and to clarify how these variables are described in the literature by patients and clinicians.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28668808</PMID>
<DateCreated><Year>2017</Year>
<Month>07</Month>
<Day>02</Day>
</DateCreated>
<DateRevised><Year>2017</Year>
<Month>07</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0315-162X</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year>
<Month>Jul</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of rheumatology</Title>
<ISOAbbreviation>J. Rheumatol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review - OMERACT Virtual Special Interest Group.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">jrheum.161107</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3899/jrheum.161107</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Beyond the exacerbation of pain in describing a flare in osteoarthritis (OA), patients and health professionals add other elements that deserve to be fully elucidated, such as effusion, swelling, and mobility limitation. To define and conceptualize the construct flare in OA, the objective was to identify the key variables, or symptoms, that worsen, and to clarify how these variables are described in the literature by patients and clinicians.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A systematic review of the literature was conducted in Medline and PsychINFO. In brief, the search terms used were "osteoarthritis," "knee," "hip," and "flare." Specific characteristics of included studies were identified, including the type of study design, type of flare assessed, how the flare developed, and what definition of flare was used, including whether the definition was based on qualitative or quantitative analysis.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Pain was the major factor in the definition of flare within these studies. Four components of flare were identified: pain, other factors, composite criteria, and global assessment. While the majority of studies reported flare as an increase in pain using standardized outcome measures, only 1 study reported the antecedents and consequences of a pain flare using qualitative methods.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The use of flare as an outcome or inclusion criterion in rheumatology trials is a common occurrence; however, this review highlights the wide variation in the definitions of OA flare currently in use and the emphasis on the measurement of pain. This variation in definition does not allow for direct comparison between trials and limits interpretation of evidence.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cross</LastName>
<ForeName>Marita</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dubouis</LastName>
<ForeName>Ludovic</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mangin</LastName>
<ForeName>Matthieu</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hunter</LastName>
<ForeName>David J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>March</LastName>
<ForeName>Lyn</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hawker</LastName>
<ForeName>Gillian</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guillemin</LastName>
<ForeName>Francis</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>07</Month>
<Day>01</Day>
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<MedlineJournalInfo><Country>Canada</Country>
<MedlineTA>J Rheumatol</MedlineTA>
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<ArticleIdList><ArticleId IdType="pubmed">28668808</ArticleId>
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<affiliations><list><country><li>Australie</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
</region>
<settlement><li>Sydney</li>
</settlement>
<orgName><li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Cross, Marita" sort="Cross, Marita" uniqKey="Cross M" first="Marita" last="Cross">Marita Cross</name>
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<name sortKey="Dubouis, Ludovic" sort="Dubouis, Ludovic" uniqKey="Dubouis L" first="Ludovic" last="Dubouis">Ludovic Dubouis</name>
<name sortKey="Guillemin, Francis" sort="Guillemin, Francis" uniqKey="Guillemin F" first="Francis" last="Guillemin">Francis Guillemin</name>
<name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name>
<name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name>
<name sortKey="Mangin, Matthieu" sort="Mangin, Matthieu" uniqKey="Mangin M" first="Matthieu" last="Mangin">Matthieu Mangin</name>
<name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name>
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