Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study.
Identifieur interne : 000D58 ( PubMed/Checkpoint ); précédent : 000D57; suivant : 000D59Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study.
Auteurs : Jordan Andrews [Australie] ; Alex Janssan [Australie] ; Tracy Nguyen [Australie] ; Anthony D. Pisaniello [Australie] ; Daniel J. Scherer [Australie] ; John J P. Kastelein [Pays-Bas] ; Bela Merkely [Hongrie] ; Steven E. Nissen [États-Unis] ; Kausik Ray [Royaume-Uni] ; Gregory G. Schwartz [États-Unis] ; Stephen G. Worthley [Australie] ; Connie Keyserling [France] ; Jean-Louis Dasseux [France] ; Julie Butters [Australie] ; Jacinta Girardi [Australie] ; Rosemary Miller [Australie] ; Stephen J. Nicholls [Australie]Source :
- Cardiovascular diagnosis and therapy [ 2223-3652 ] ; 2017.
Abstract
High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy remains elusive. Early studies have suggested that infusion of reconstituted HDL promotes reverse cholesterol transport and vascular reactivity. The CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial (CARAT) is investigating the impact of infusing an engineered pre-beta HDL mimetic containing sphingomyelin (SM) and dipalmitoyl phosphatidlyglycerol (CER-001) on coronary atheroma volume in patients with a recent acute coronary syndrome (ACS).
DOI: 10.21037/cdt.2017.01.01
PubMed: 28164012
Affiliations:
- Australie, France, Hongrie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Colorado, Grand Londres, Hollande-Septentrionale, Hongrie centrale, Midi-Pyrénées, Occitanie (région administrative), Ohio
- Amsterdam, Budapest, Londres, Toulouse
- Université d'Amsterdam
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Schwartz</name><affiliation wicri:level="2"><nlm:affiliation>University of Colorado School of Medicine, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Colorado School of Medicine, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Worthley, Stephen G" sort="Worthley, Stephen G" uniqKey="Worthley S" first="Stephen G" last="Worthley">Stephen G. Worthley</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Keyserling, Connie" sort="Keyserling, Connie" uniqKey="Keyserling C" first="Connie" last="Keyserling">Connie Keyserling</name><affiliation wicri:level="3"><nlm:affiliation>Cerenis Pharmaceuticals, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cerenis Pharmaceuticals, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Dasseux, Jean Louis" sort="Dasseux, Jean Louis" uniqKey="Dasseux J" first="Jean-Louis" last="Dasseux">Jean-Louis Dasseux</name><affiliation wicri:level="3"><nlm:affiliation>Cerenis Pharmaceuticals, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cerenis Pharmaceuticals, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Butters, Julie" sort="Butters, Julie" uniqKey="Butters J" first="Julie" last="Butters">Julie Butters</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Girardi, Jacinta" sort="Girardi, Jacinta" uniqKey="Girardi J" first="Jacinta" last="Girardi">Jacinta Girardi</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Rosemary" sort="Miller, Rosemary" uniqKey="Miller R" first="Rosemary" last="Miller">Rosemary Miller</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Nicholls, Stephen J" sort="Nicholls, Stephen J" uniqKey="Nicholls S" first="Stephen J" last="Nicholls">Stephen J. Nicholls</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28164012</idno><idno type="pmid">28164012</idno><idno type="doi">10.21037/cdt.2017.01.01</idno><idno type="wicri:Area/PubMed/Corpus">001076</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001076</idno><idno type="wicri:Area/PubMed/Curation">001073</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001073</idno><idno type="wicri:Area/PubMed/Checkpoint">001073</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001073</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study.</title><author><name sortKey="Andrews, Jordan" sort="Andrews, Jordan" uniqKey="Andrews J" first="Jordan" last="Andrews">Jordan Andrews</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Janssan, Alex" sort="Janssan, Alex" uniqKey="Janssan A" first="Alex" last="Janssan">Alex Janssan</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Tracy" sort="Nguyen, Tracy" uniqKey="Nguyen T" first="Tracy" last="Nguyen">Tracy Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Pisaniello, Anthony D" sort="Pisaniello, Anthony D" uniqKey="Pisaniello A" first="Anthony D" last="Pisaniello">Anthony D. Pisaniello</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Scherer, Daniel J" sort="Scherer, Daniel J" uniqKey="Scherer D" first="Daniel J" last="Scherer">Daniel J. Scherer</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name><affiliation wicri:level="4"><nlm:affiliation>Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Merkely, Bela" sort="Merkely, Bela" uniqKey="Merkely B" first="Bela" last="Merkely">Bela Merkely</name><affiliation wicri:level="3"><nlm:affiliation>Heart and Vascular Center, Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heart and Vascular Center, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Nissen, Steven E" sort="Nissen, Steven E" uniqKey="Nissen S" first="Steven E" last="Nissen">Steven E. Nissen</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Ray, Kausik" sort="Ray, Kausik" uniqKey="Ray K" first="Kausik" last="Ray">Kausik Ray</name><affiliation wicri:level="3"><nlm:affiliation>School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schwartz, Gregory G" sort="Schwartz, Gregory G" uniqKey="Schwartz G" first="Gregory G" last="Schwartz">Gregory G. Schwartz</name><affiliation wicri:level="2"><nlm:affiliation>University of Colorado School of Medicine, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Colorado School of Medicine, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Worthley, Stephen G" sort="Worthley, Stephen G" uniqKey="Worthley S" first="Stephen G" last="Worthley">Stephen G. Worthley</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Keyserling, Connie" sort="Keyserling, Connie" uniqKey="Keyserling C" first="Connie" last="Keyserling">Connie Keyserling</name><affiliation wicri:level="3"><nlm:affiliation>Cerenis Pharmaceuticals, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cerenis Pharmaceuticals, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Dasseux, Jean Louis" sort="Dasseux, Jean Louis" uniqKey="Dasseux J" first="Jean-Louis" last="Dasseux">Jean-Louis Dasseux</name><affiliation wicri:level="3"><nlm:affiliation>Cerenis Pharmaceuticals, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cerenis Pharmaceuticals, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Butters, Julie" sort="Butters, Julie" uniqKey="Butters J" first="Julie" last="Butters">Julie Butters</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Girardi, Jacinta" sort="Girardi, Jacinta" uniqKey="Girardi J" first="Jacinta" last="Girardi">Jacinta Girardi</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Rosemary" sort="Miller, Rosemary" uniqKey="Miller R" first="Rosemary" last="Miller">Rosemary Miller</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Nicholls, Stephen J" sort="Nicholls, Stephen J" uniqKey="Nicholls S" first="Stephen J" last="Nicholls">Stephen J. Nicholls</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cardiovascular diagnosis and therapy</title><idno type="ISSN">2223-3652</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy remains elusive. Early studies have suggested that infusion of reconstituted HDL promotes reverse cholesterol transport and vascular reactivity. The CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial (CARAT) is investigating the impact of infusing an engineered pre-beta HDL mimetic containing sphingomyelin (SM) and dipalmitoyl phosphatidlyglycerol (CER-001) on coronary atheroma volume in patients with a recent acute coronary syndrome (ACS).</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28164012</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>06</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2223-3652</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Cardiovascular diagnosis and therapy</Title><ISOAbbreviation>Cardiovasc Diagn Ther</ISOAbbreviation></Journal><ArticleTitle>Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study.</ArticleTitle><Pagination><MedlinePgn>45-51</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.21037/cdt.2017.01.01</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy remains elusive. Early studies have suggested that infusion of reconstituted HDL promotes reverse cholesterol transport and vascular reactivity. The CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial (CARAT) is investigating the impact of infusing an engineered pre-beta HDL mimetic containing sphingomyelin (SM) and dipalmitoyl phosphatidlyglycerol (CER-001) on coronary atheroma volume in patients with a recent acute coronary syndrome (ACS).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The CARAT is a phase 2, multicenter trial in which 292 patients with an ACS undergoing intracoronary ultrasonography and showing percent atheroma volume (PAV) greater than 30% are randomly assigned to treatment with ten infusions of CER-001 3 mg/kg or matching placebo, administered at weekly intervals. Intracoronary ultrasonography is repeated at the end of the treatment period.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The primary endpoint is the nominal change in PAV. Safety and tolerability will also be evaluated.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">CARAT will establish whether serial 3 mg/kg infusions of an engineered pre-beta HDL mimetic containing SM and dipalmitoyl phosphatidlyglycerol (CER-001) will regress atherosclerotic plaque in patients with a recent ACS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Andrews</LastName><ForeName>Jordan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janssan</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Tracy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pisaniello</LastName><ForeName>Anthony D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scherer</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kastelein</LastName><ForeName>John J P</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merkely</LastName><ForeName>Bela</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Heart and Vascular Center, Semmelweis University, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nissen</LastName><ForeName>Steven E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Cleveland Clinic, Cleveland, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ray</LastName><ForeName>Kausik</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwartz</LastName><ForeName>Gregory G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>University of Colorado School of Medicine, Denver, CO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Worthley</LastName><ForeName>Stephen G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keyserling</LastName><ForeName>Connie</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Cerenis Pharmaceuticals, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dasseux</LastName><ForeName>Jean-Louis</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Cerenis Pharmaceuticals, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butters</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girardi</LastName><ForeName>Jacinta</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Rosemary</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicholls</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China (Republic 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Version="1">23999933</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2007 Sep 27;357(13):1301-10</RefSource><PMID Version="1">17898099</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2008 Apr 2;299(13):1547-60</RefSource><PMID Version="1">18387931</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2004 Nov 10;292(18):2217-25</RefSource><PMID Version="1">15536108</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Coll Cardiol. 2014 Aug 5;64(5):485-94</RefSource><PMID Version="1">25082583</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2005 Nov 26;366(9500):1849-61</RefSource><PMID Version="1">16310551</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Atherosclerosis</Keyword><Keyword MajorTopicYN="N">CER-001</Keyword><Keyword MajorTopicYN="N">clinical trial</Keyword><Keyword MajorTopicYN="N">high-density lipoproteins (HDLs)</Keyword><Keyword MajorTopicYN="N">intravascular ultrasound</Keyword></KeywordList><CoiStatement>The authors have no conflicts of interest to declare.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>7</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28164012</ArticleId><ArticleId IdType="doi">10.21037/cdt.2017.01.01</ArticleId><ArticleId IdType="pii">cdt-07-01-045</ArticleId><ArticleId IdType="pmc">PMC5253449</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Hongrie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Colorado</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Hongrie centrale</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Ohio</li></region><settlement><li>Amsterdam</li><li>Budapest</li><li>Londres</li><li>Toulouse</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Andrews, Jordan" sort="Andrews, Jordan" uniqKey="Andrews J" first="Jordan" last="Andrews">Jordan Andrews</name></noRegion><name sortKey="Butters, Julie" sort="Butters, Julie" uniqKey="Butters J" first="Julie" last="Butters">Julie Butters</name><name sortKey="Girardi, Jacinta" sort="Girardi, Jacinta" uniqKey="Girardi J" first="Jacinta" last="Girardi">Jacinta Girardi</name><name sortKey="Janssan, Alex" sort="Janssan, Alex" uniqKey="Janssan A" first="Alex" last="Janssan">Alex Janssan</name><name sortKey="Miller, Rosemary" sort="Miller, Rosemary" uniqKey="Miller R" first="Rosemary" last="Miller">Rosemary Miller</name><name sortKey="Nguyen, Tracy" sort="Nguyen, Tracy" uniqKey="Nguyen T" first="Tracy" last="Nguyen">Tracy Nguyen</name><name sortKey="Nicholls, Stephen J" sort="Nicholls, Stephen J" uniqKey="Nicholls S" first="Stephen J" last="Nicholls">Stephen J. Nicholls</name><name sortKey="Pisaniello, Anthony D" sort="Pisaniello, Anthony D" uniqKey="Pisaniello A" first="Anthony D" last="Pisaniello">Anthony D. Pisaniello</name><name sortKey="Scherer, Daniel J" sort="Scherer, Daniel J" uniqKey="Scherer D" first="Daniel J" last="Scherer">Daniel J. Scherer</name><name sortKey="Worthley, Stephen G" sort="Worthley, Stephen G" uniqKey="Worthley S" first="Stephen G" last="Worthley">Stephen G. Worthley</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name></region></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Merkely, Bela" sort="Merkely, Bela" uniqKey="Merkely B" first="Bela" last="Merkely">Bela Merkely</name></region></country><country name="États-Unis"><region name="Ohio"><name sortKey="Nissen, Steven E" sort="Nissen, Steven E" uniqKey="Nissen S" first="Steven E" last="Nissen">Steven E. Nissen</name></region><name sortKey="Schwartz, Gregory G" sort="Schwartz, Gregory G" uniqKey="Schwartz G" first="Gregory G" last="Schwartz">Gregory G. Schwartz</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ray, Kausik" sort="Ray, Kausik" uniqKey="Ray K" first="Kausik" last="Ray">Kausik Ray</name></region></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Keyserling, Connie" sort="Keyserling, Connie" uniqKey="Keyserling C" first="Connie" last="Keyserling">Connie Keyserling</name></region><name sortKey="Dasseux, Jean Louis" sort="Dasseux, Jean Louis" uniqKey="Dasseux J" first="Jean-Louis" last="Dasseux">Jean-Louis Dasseux</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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