Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial.
Identifieur interne : 000D03 ( PubMed/Checkpoint ); précédent : 000D02; suivant : 000D04Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial.
Auteurs : Markus B. Skrifvars [Australie] ; Michael Bailey ; Craig French ; Jeffrey Presneill ; Alistair Nichol ; Lorraine Little ; Jacques Duranteau ; Olivier Huet ; Samir Haddad ; Yaseen Arabi ; Colin Mcarthur ; D James Cooper ; Rinaldo BellomoSource :
- The journal of trauma and acute care surgery [ 2163-0763 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Lésions traumatiques de l'encéphale (mortalité), Lésions traumatiques de l'encéphale (traitement médicamenteux), Mâle, Polytraumatisme, Résultat thérapeutique, Score de gravité des lésions traumatiques, Échelle abrégée des traumatismes, Érythropoïétine (usage thérapeutique).
- MESH :
- mortalité : Lésions traumatiques de l'encéphale.
- traitement médicamenteux : Lésions traumatiques de l'encéphale.
- usage thérapeutique : Érythropoïétine.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Polytraumatisme, Résultat thérapeutique, Score de gravité des lésions traumatiques, Échelle abrégée des traumatismes.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Erythropoietin.
- drug therapy : Brain Injuries, Traumatic.
- mortality : Brain Injuries, Traumatic.
- Abbreviated Injury Scale, Adult, Female, Humans, Injury Severity Score, Male, Middle Aged, Multiple Trauma, Treatment Outcome.
Abstract
Erythropoietin (EPO) may reduce mortality after traumatic brain injury (TBI). Secondary brain injury is exacerbated by multiple trauma, and possibly modifiable by EPO. We hypothesized that EPO decreases mortality more in TBI patients with multiple trauma, than in patients with TBI alone.
DOI: 10.1097/TA.0000000000001594
PubMed: 28590358
Affiliations:
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pubmed:28590358Le document en format XML
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Skrifvars</name><affiliation wicri:level="1"><nlm:affiliation>From the Australian and New Zealand Intensive Care Research Centre (M.B.S., M.B., C.F., J.P., A.N., L.L., D.J.C., R.B.), School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Division of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine (M.B.S.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Intensive Care Helsinki, Finland; Department of Intensive Care (C.F.), Western Health; University of Melbourne (C.F.); Department of Intensive Care (J.P.), Royal Melbourne Hospital, Melbourne, Victoria, Australia; School of Medicine and Medical Sciences (A.N.), University College Dublin, Dublin, Ireland; Department of Intensive Care and Hyperbaric Medicine (A.N., D.J.C.), The Alfred, Melbourne, Victoria, Australia; Département d'Anesthésie-Réanimation (J.D.), Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris; Department of Anaesthesiology and Intensive Care Medicine (O.H.), CHU La Cavale Blanche, Brest, France; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center (S.H., Y.A.), Riyadh, Saudi Arabia; Auckland City Hospital (C.M.), Auckland, New Zealand; and Department of Intensive Care (R.B.), Austin Health, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>From the Australian and New Zealand Intensive Care Research Centre (M.B.S., M.B., C.F., J.P., A.N., L.L., D.J.C., R.B.), School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Division of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine (M.B.S.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Intensive Care Helsinki, Finland; Department of Intensive Care (C.F.), Western Health; University of Melbourne (C.F.); Department of Intensive Care (J.P.), Royal Melbourne Hospital, Melbourne, Victoria, Australia; School of Medicine and Medical Sciences (A.N.), University College Dublin, Dublin, Ireland; Department of Intensive Care and Hyperbaric Medicine (A.N., D.J.C.), The Alfred, Melbourne, Victoria, Australia; Département d'Anesthésie-Réanimation (J.D.), Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris; Department of Anaesthesiology and Intensive Care Medicine (O.H.), CHU La Cavale Blanche, Brest, France; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center (S.H., Y.A.), Riyadh, Saudi Arabia; Auckland City Hospital (C.M.), Auckland, New Zealand; and Department of Intensive Care (R.B.), Austin Health, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name></author><author><name sortKey="French, Craig" sort="French, Craig" uniqKey="French C" first="Craig" last="French">Craig French</name></author><author><name sortKey="Presneill, Jeffrey" sort="Presneill, Jeffrey" uniqKey="Presneill J" first="Jeffrey" last="Presneill">Jeffrey Presneill</name></author><author><name sortKey="Nichol, Alistair" sort="Nichol, Alistair" uniqKey="Nichol A" first="Alistair" last="Nichol">Alistair Nichol</name></author><author><name sortKey="Little, Lorraine" sort="Little, Lorraine" uniqKey="Little L" first="Lorraine" last="Little">Lorraine Little</name></author><author><name sortKey="Duranteau, Jacques" sort="Duranteau, Jacques" uniqKey="Duranteau J" first="Jacques" last="Duranteau">Jacques Duranteau</name></author><author><name sortKey="Huet, Olivier" sort="Huet, Olivier" uniqKey="Huet O" first="Olivier" last="Huet">Olivier Huet</name></author><author><name sortKey="Haddad, Samir" sort="Haddad, Samir" uniqKey="Haddad S" first="Samir" last="Haddad">Samir Haddad</name></author><author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name></author><author><name sortKey="Mcarthur, Colin" sort="Mcarthur, Colin" uniqKey="Mcarthur C" first="Colin" last="Mcarthur">Colin Mcarthur</name></author><author><name sortKey="Cooper, D James" sort="Cooper, D James" uniqKey="Cooper D" first="D James" last="Cooper">D James Cooper</name></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28590358</idno><idno type="pmid">28590358</idno><idno type="doi">10.1097/TA.0000000000001594</idno><idno type="wicri:Area/PubMed/Corpus">000646</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000646</idno><idno type="wicri:Area/PubMed/Curation">000644</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000644</idno><idno type="wicri:Area/PubMed/Checkpoint">000644</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000644</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial.</title><author><name sortKey="Skrifvars, Markus B" sort="Skrifvars, Markus B" uniqKey="Skrifvars M" first="Markus B" last="Skrifvars">Markus B. Skrifvars</name><affiliation wicri:level="1"><nlm:affiliation>From the Australian and New Zealand Intensive Care Research Centre (M.B.S., M.B., C.F., J.P., A.N., L.L., D.J.C., R.B.), School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Division of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine (M.B.S.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Intensive Care Helsinki, Finland; Department of Intensive Care (C.F.), Western Health; University of Melbourne (C.F.); Department of Intensive Care (J.P.), Royal Melbourne Hospital, Melbourne, Victoria, Australia; School of Medicine and Medical Sciences (A.N.), University College Dublin, Dublin, Ireland; Department of Intensive Care and Hyperbaric Medicine (A.N., D.J.C.), The Alfred, Melbourne, Victoria, Australia; Département d'Anesthésie-Réanimation (J.D.), Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris; Department of Anaesthesiology and Intensive Care Medicine (O.H.), CHU La Cavale Blanche, Brest, France; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center (S.H., Y.A.), Riyadh, Saudi Arabia; Auckland City Hospital (C.M.), Auckland, New Zealand; and Department of Intensive Care (R.B.), Austin Health, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>From the Australian and New Zealand Intensive Care Research Centre (M.B.S., M.B., C.F., J.P., A.N., L.L., D.J.C., R.B.), School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Division of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine (M.B.S.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Intensive Care Helsinki, Finland; Department of Intensive Care (C.F.), Western Health; University of Melbourne (C.F.); Department of Intensive Care (J.P.), Royal Melbourne Hospital, Melbourne, Victoria, Australia; School of Medicine and Medical Sciences (A.N.), University College Dublin, Dublin, Ireland; Department of Intensive Care and Hyperbaric Medicine (A.N., D.J.C.), The Alfred, Melbourne, Victoria, Australia; Département d'Anesthésie-Réanimation (J.D.), Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris; Department of Anaesthesiology and Intensive Care Medicine (O.H.), CHU La Cavale Blanche, Brest, France; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center (S.H., Y.A.), Riyadh, Saudi Arabia; Auckland City Hospital (C.M.), Auckland, New Zealand; and Department of Intensive Care (R.B.), Austin Health, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name></author><author><name sortKey="French, Craig" sort="French, Craig" uniqKey="French C" first="Craig" last="French">Craig French</name></author><author><name sortKey="Presneill, Jeffrey" sort="Presneill, Jeffrey" uniqKey="Presneill J" first="Jeffrey" last="Presneill">Jeffrey Presneill</name></author><author><name sortKey="Nichol, Alistair" sort="Nichol, Alistair" uniqKey="Nichol A" first="Alistair" last="Nichol">Alistair Nichol</name></author><author><name sortKey="Little, Lorraine" sort="Little, Lorraine" uniqKey="Little L" first="Lorraine" last="Little">Lorraine Little</name></author><author><name sortKey="Duranteau, Jacques" sort="Duranteau, Jacques" uniqKey="Duranteau J" first="Jacques" last="Duranteau">Jacques Duranteau</name></author><author><name sortKey="Huet, Olivier" sort="Huet, Olivier" uniqKey="Huet O" first="Olivier" last="Huet">Olivier Huet</name></author><author><name sortKey="Haddad, Samir" sort="Haddad, Samir" uniqKey="Haddad S" first="Samir" last="Haddad">Samir Haddad</name></author><author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name></author><author><name sortKey="Mcarthur, Colin" sort="Mcarthur, Colin" uniqKey="Mcarthur C" first="Colin" last="Mcarthur">Colin Mcarthur</name></author><author><name sortKey="Cooper, D James" sort="Cooper, D James" uniqKey="Cooper D" first="D James" last="Cooper">D James Cooper</name></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name></author></analytic><series><title level="j">The journal of trauma and acute care surgery</title><idno type="eISSN">2163-0763</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbreviated Injury Scale</term><term>Adult</term><term>Brain Injuries, Traumatic (drug therapy)</term><term>Brain Injuries, Traumatic (mortality)</term><term>Erythropoietin (therapeutic use)</term><term>Female</term><term>Humans</term><term>Injury Severity Score</term><term>Male</term><term>Middle Aged</term><term>Multiple Trauma</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Lésions traumatiques de l'encéphale (mortalité)</term><term>Lésions traumatiques de l'encéphale (traitement médicamenteux)</term><term>Mâle</term><term>Polytraumatisme</term><term>Résultat thérapeutique</term><term>Score de gravité des lésions traumatiques</term><term>Échelle abrégée des traumatismes</term><term>Érythropoïétine (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Erythropoietin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Brain Injuries, Traumatic</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Brain Injuries, Traumatic</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Lésions traumatiques de l'encéphale</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lésions traumatiques de l'encéphale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Érythropoïétine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Abbreviated Injury Scale</term><term>Adult</term><term>Female</term><term>Humans</term><term>Injury Severity Score</term><term>Male</term><term>Middle Aged</term><term>Multiple Trauma</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Polytraumatisme</term><term>Résultat thérapeutique</term><term>Score de gravité des lésions traumatiques</term><term>Échelle abrégée des traumatismes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Erythropoietin (EPO) may reduce mortality after traumatic brain injury (TBI). Secondary brain injury is exacerbated by multiple trauma, and possibly modifiable by EPO. We hypothesized that EPO decreases mortality more in TBI patients with multiple trauma, than in patients with TBI alone.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28590358</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>07</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>18</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2163-0763</ISSN><JournalIssue CitedMedium="Internet"><Volume>83</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Sep</Month></PubDate></JournalIssue><Title>The journal of trauma and acute care surgery</Title><ISOAbbreviation>J Trauma Acute Care Surg</ISOAbbreviation></Journal><ArticleTitle>Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial.</ArticleTitle><Pagination><MedlinePgn>449-456</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/TA.0000000000001594</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Erythropoietin (EPO) may reduce mortality after traumatic brain injury (TBI). Secondary brain injury is exacerbated by multiple trauma, and possibly modifiable by EPO. We hypothesized that EPO decreases mortality more in TBI patients with multiple trauma, than in patients with TBI alone.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A post hoc analysis of the EPO-TBI randomized controlled trial conducted in 2009 to 2014. To evaluate the impact of injuries outside the brain, we calculated an extracranial Injury Severity Score (ISS) that included the same components of the ISS, excluding head and face components. We defined multiple trauma as two injured body regions with an Abbreviated Injury Scale (AIS) score of 3 or higher. Cox regression analyses, allowing for potential differential responses per the presence or absence of extracranial injury defined by these injury scores, were used to assess the effect of EPO on time to mortality.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 603 included patients, the median extracranial ISS was 6 (interquartile range, 1-13) and 258 (43%) had an AIS score of 3 or higher in at least two body regions. On Cox regression, EPO was associated with decreased mortality in patients with greater extracranial ISS (interaction p = 0.048) and weakly associated with differential mortality with multiple trauma (AIS score > 3 or in two regions, interaction p = 0.17). At 6 months in patients with extracranial ISS higher than 6, 10 (6.8%) of 147 EPO-treated patients compared with 26 (17%) of 154 placebo-treated patients died (risk reduction, 10%; 95% confidence interval, 2.9-17%; p = 0.007).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this post hoc analysis, EPO administration was associated with a potential differential improvement in 6-month mortality in TBI patients with more severe extracranial injury. These findings need confirmation in future clinical and experimental studies.</AbstractText><AbstractText Label="LEVEL OF EVIDENCE" NlmCategory="METHODS">Therapeutic study, level III.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Skrifvars</LastName><ForeName>Markus B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>From the Australian and New Zealand Intensive Care Research Centre (M.B.S., M.B., C.F., J.P., A.N., L.L., D.J.C., R.B.), School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Division of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine (M.B.S.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Intensive Care Helsinki, Finland; Department of Intensive Care (C.F.), Western Health; University of Melbourne (C.F.); Department of Intensive Care (J.P.), Royal Melbourne Hospital, Melbourne, Victoria, Australia; School of Medicine and Medical Sciences (A.N.), University College Dublin, Dublin, Ireland; Department of Intensive Care and Hyperbaric Medicine (A.N., D.J.C.), The Alfred, Melbourne, Victoria, Australia; Département d'Anesthésie-Réanimation (J.D.), Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris; Department of Anaesthesiology and Intensive Care Medicine (O.H.), CHU La Cavale Blanche, Brest, France; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center (S.H., Y.A.), Riyadh, Saudi Arabia; Auckland City Hospital (C.M.), Auckland, New Zealand; and Department of Intensive Care (R.B.), Austin Health, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>French</LastName><ForeName>Craig</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Presneill</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Nichol</LastName><ForeName>Alistair</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Little</LastName><ForeName>Lorraine</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Duranteau</LastName><ForeName>Jacques</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Huet</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Haddad</LastName><ForeName>Samir</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Arabi</LastName><ForeName>Yaseen</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>McArthur</LastName><ForeName>Colin</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>D James</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Bellomo</LastName><ForeName>Rinaldo</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><CollectiveName>EPO-TBI investigators and the ANZICS Clinical Trials Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Trauma Acute Care Surg</MedlineTA><NlmUniqueID>101570622</NlmUniqueID><ISSNLinking>2163-0755</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>11096-26-7</RegistryNumber><NameOfSubstance UI="D004921">Erythropoietin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015998" MajorTopicYN="N">Abbreviated Injury Scale</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000070642" MajorTopicYN="N">Brain Injuries, Traumatic</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004921" MajorTopicYN="N">Erythropoietin</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015601" MajorTopicYN="N">Injury Severity Score</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009104" MajorTopicYN="N">Multiple Trauma</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28590358</ArticleId><ArticleId IdType="doi">10.1097/TA.0000000000001594</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><name sortKey="Cooper, D James" sort="Cooper, D James" uniqKey="Cooper D" first="D James" last="Cooper">D James Cooper</name><name sortKey="Duranteau, Jacques" sort="Duranteau, Jacques" uniqKey="Duranteau J" first="Jacques" last="Duranteau">Jacques Duranteau</name><name sortKey="French, Craig" sort="French, Craig" uniqKey="French C" first="Craig" last="French">Craig French</name><name sortKey="Haddad, Samir" sort="Haddad, Samir" uniqKey="Haddad S" first="Samir" last="Haddad">Samir Haddad</name><name sortKey="Huet, Olivier" sort="Huet, Olivier" uniqKey="Huet O" first="Olivier" last="Huet">Olivier Huet</name><name sortKey="Little, Lorraine" sort="Little, Lorraine" uniqKey="Little L" first="Lorraine" last="Little">Lorraine Little</name><name sortKey="Mcarthur, Colin" sort="Mcarthur, Colin" uniqKey="Mcarthur C" first="Colin" last="Mcarthur">Colin Mcarthur</name><name sortKey="Nichol, Alistair" sort="Nichol, Alistair" uniqKey="Nichol A" first="Alistair" last="Nichol">Alistair Nichol</name><name sortKey="Presneill, Jeffrey" sort="Presneill, Jeffrey" uniqKey="Presneill J" first="Jeffrey" last="Presneill">Jeffrey Presneill</name></noCountry><country name="Australie"><noRegion><name sortKey="Skrifvars, Markus B" sort="Skrifvars, Markus B" uniqKey="Skrifvars M" first="Markus B" last="Skrifvars">Markus B. 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|texte= Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial.
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Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:28590358" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
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