Experimental dyspnea as a stressor: differential cardiovegetative responses to inspiratory threshold loading in healthy men and women.
Identifieur interne : 000C59 ( PubMed/Checkpoint ); précédent : 000C58; suivant : 000C60Experimental dyspnea as a stressor: differential cardiovegetative responses to inspiratory threshold loading in healthy men and women.
Auteurs : Marie-Cécile Niérat [France] ; Louis Laviolette [France] ; Anna Hudson [France] ; Thomas Similowski [France] ; Caroline Sévoz-Couche [France]Source :
- Journal of applied physiology (Bethesda, Md. : 1985) [ 1522-1601 ] ; 2017.
Abstract
Dyspnea is associated with an emotional reaction that involves limbic activation. The inspiratory threshold load (ITL) is known to elicit a dyspneic response in healthy subjects. Laboratory-induced stress conditions have been shown to elicit sex-related differences in cardiovascular responses. The aim of this study was to evaluate how healthy men (n = 8) and women (n = 9) react and adapt to 5-min periods of ITL at three levels (low, medium, and high) in terms of heart rate (HR), temporal (RMSSD) and spectral (LF, HF, LF/HF ratio) HRV indexes, and rating of breathing discomfort. HR increased with low, medium, and high ITL in men, whereas it increased only with high ITL in women. LF/HF ratio increased at low ITL in both men and women. Modifications appear to depend essentially on increased LF in men and on reduced HF in women. In addition, HRV modifications differ between men and women, following the order of presentation of ITLs. Our results show a continuous and sustained stress in men (increased HR, LF, and LF/HF ratio across ITL presentation) and a stress adaptation in women. Subjective responses of breathing discomfort were not correlated with sympatho-vagal balance modifications for a subgroup of subjects (n = 10). Breathing against the ITL induced autonomic modifications that are different between men and women, i.e., driven by sympathetic mediated responses in men, whereas women showed a greater parasympathetic modulation of cardiovascular activity. These results highlight the role of the mechanical inspiratory load in the heart rate variability seen in chronic obstructive pulmonary disease.NEW & NOTEWORTHY Breathing against the ITL induced autonomic modifications driven by sympathetic mediated responses in men, whereas women showed a greater parasympathetic modulation of cardiovascular activity, even for low load. A stress circuit could be at the origin of autonomic modifications induced by ITL. Our results would underline the role of the mechanic inspiratory load in the abnormalities in heart rate variability seen in COPD patients.
DOI: 10.1152/japplphysiol.00078.2017
PubMed: 28473608
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caroline.sevoz-couche@upmc.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Sorbonne Universités, UPMC Universite Paris 06, INSERM, UMRS1158 "Neurophysiologie respiratoire expérimentale et clinique", Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of applied physiology (Bethesda, Md. : 1985)</title><idno type="eISSN">1522-1601</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dyspnea is associated with an emotional reaction that involves limbic activation. The inspiratory threshold load (ITL) is known to elicit a dyspneic response in healthy subjects. Laboratory-induced stress conditions have been shown to elicit sex-related differences in cardiovascular responses. The aim of this study was to evaluate how healthy men (n = 8) and women (n = 9) react and adapt to 5-min periods of ITL at three levels (low, medium, and high) in terms of heart rate (HR), temporal (RMSSD) and spectral (LF, HF, LF/HF ratio) HRV indexes, and rating of breathing discomfort. HR increased with low, medium, and high ITL in men, whereas it increased only with high ITL in women. LF/HF ratio increased at low ITL in both men and women. Modifications appear to depend essentially on increased LF in men and on reduced HF in women. In addition, HRV modifications differ between men and women, following the order of presentation of ITLs. Our results show a continuous and sustained stress in men (increased HR, LF, and LF/HF ratio across ITL presentation) and a stress adaptation in women. Subjective responses of breathing discomfort were not correlated with sympatho-vagal balance modifications for a subgroup of subjects (n = 10). Breathing against the ITL induced autonomic modifications that are different between men and women, i.e., driven by sympathetic mediated responses in men, whereas women showed a greater parasympathetic modulation of cardiovascular activity. These results highlight the role of the mechanical inspiratory load in the heart rate variability seen in chronic obstructive pulmonary disease.NEW & NOTEWORTHY Breathing against the ITL induced autonomic modifications driven by sympathetic mediated responses in men, whereas women showed a greater parasympathetic modulation of cardiovascular activity, even for low load. A stress circuit could be at the origin of autonomic modifications induced by ITL. Our results would underline the role of the mechanic inspiratory load in the abnormalities in heart rate variability seen in COPD patients.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28473608</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>05</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-1601</ISSN><JournalIssue CitedMedium="Internet"><Volume>123</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jul</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of applied physiology (Bethesda, Md. : 1985)</Title><ISOAbbreviation>J. Appl. Physiol.</ISOAbbreviation></Journal><ArticleTitle>Experimental dyspnea as a stressor: differential cardiovegetative responses to inspiratory threshold loading in healthy men and women.</ArticleTitle><Pagination><MedlinePgn>205-212</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1152/japplphysiol.00078.2017</ELocationID><Abstract><AbstractText>Dyspnea is associated with an emotional reaction that involves limbic activation. The inspiratory threshold load (ITL) is known to elicit a dyspneic response in healthy subjects. Laboratory-induced stress conditions have been shown to elicit sex-related differences in cardiovascular responses. The aim of this study was to evaluate how healthy men (n = 8) and women (n = 9) react and adapt to 5-min periods of ITL at three levels (low, medium, and high) in terms of heart rate (HR), temporal (RMSSD) and spectral (LF, HF, LF/HF ratio) HRV indexes, and rating of breathing discomfort. HR increased with low, medium, and high ITL in men, whereas it increased only with high ITL in women. LF/HF ratio increased at low ITL in both men and women. Modifications appear to depend essentially on increased LF in men and on reduced HF in women. In addition, HRV modifications differ between men and women, following the order of presentation of ITLs. Our results show a continuous and sustained stress in men (increased HR, LF, and LF/HF ratio across ITL presentation) and a stress adaptation in women. Subjective responses of breathing discomfort were not correlated with sympatho-vagal balance modifications for a subgroup of subjects (n = 10). Breathing against the ITL induced autonomic modifications that are different between men and women, i.e., driven by sympathetic mediated responses in men, whereas women showed a greater parasympathetic modulation of cardiovascular activity. These results highlight the role of the mechanical inspiratory load in the heart rate variability seen in chronic obstructive pulmonary disease.NEW & NOTEWORTHY Breathing against the ITL induced autonomic modifications driven by sympathetic mediated responses in men, whereas women showed a greater parasympathetic modulation of cardiovascular activity, even for low load. A stress circuit could be at the origin of autonomic modifications induced by ITL. Our results would underline the role of the mechanic inspiratory load in the abnormalities in heart rate variability seen in COPD patients.</AbstractText><CopyrightInformation>Copyright © 2017 the American Physiological Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Niérat</LastName><ForeName>Marie-Cécile</ForeName><Initials>MC</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9370-7301</Identifier><AffiliationInfo><Affiliation>Sorbonne Universités, UPMC Universite Paris 06, INSERM, UMRS1158 "Neurophysiologie respiratoire expérimentale et clinique", Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laviolette</LastName><ForeName>Louis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Sorbonne Universités, UPMC Universite Paris 06, INSERM, UMRS1158 "Neurophysiologie respiratoire expérimentale et clinique", Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hudson</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sorbonne Universités, UPMC Universite Paris 06, INSERM, UMRS1158 "Neurophysiologie respiratoire expérimentale et clinique", Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neuroscience Research Australia and University of New South Wales, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Similowski</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2868-9279</Identifier><AffiliationInfo><Affiliation>Sorbonne Universités, UPMC Universite Paris 06, INSERM, UMRS1158 "Neurophysiologie respiratoire expérimentale et clinique", Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie et Réanimation Médicale ("Département R3S"), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sévoz-Couche</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Sorbonne Universités, UPMC Universite Paris 06, INSERM, UMRS1158 "Neurophysiologie respiratoire expérimentale et clinique", Paris, France; caroline.sevoz-couche@upmc.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Appl Physiol (1985)</MedlineTA><NlmUniqueID>8502536</NlmUniqueID><ISSNLinking>0161-7567</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ITL</Keyword><Keyword MajorTopicYN="N">dyspnea</Keyword><Keyword MajorTopicYN="N">gender differences</Keyword><Keyword MajorTopicYN="N">healthy subjects</Keyword><Keyword MajorTopicYN="N">short-term HRV</Keyword><Keyword MajorTopicYN="N">stress</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>01</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>04</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>04</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28473608</ArticleId><ArticleId IdType="pii">japplphysiol.00078.2017</ArticleId><ArticleId IdType="doi">10.1152/japplphysiol.00078.2017</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Nierat, Marie Cecile" sort="Nierat, Marie Cecile" uniqKey="Nierat M" first="Marie-Cécile" last="Niérat">Marie-Cécile Niérat</name></region><name sortKey="Hudson, Anna" sort="Hudson, Anna" uniqKey="Hudson A" first="Anna" last="Hudson">Anna Hudson</name><name sortKey="Laviolette, Louis" sort="Laviolette, Louis" uniqKey="Laviolette L" first="Louis" last="Laviolette">Louis Laviolette</name><name sortKey="Sevoz Couche, Caroline" sort="Sevoz Couche, Caroline" uniqKey="Sevoz Couche C" first="Caroline" last="Sévoz-Couche">Caroline Sévoz-Couche</name><name sortKey="Similowski, Thomas" sort="Similowski, Thomas" uniqKey="Similowski T" first="Thomas" last="Similowski">Thomas Similowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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