Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.
Identifieur interne : 000C42 ( PubMed/Checkpoint ); précédent : 000C41; suivant : 000C43Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.
Auteurs : Ira M. Jacobson [États-Unis] ; Mary K. Washington [États-Unis] ; Maria Buti [Espagne] ; Alexander Thompson [Australie] ; Nezam Afdhal [États-Unis] ; Robert Flisiak [Pologne] ; Ulus Salih Akarca [Turquie] ; Konstantin G. Tchernev [Bulgarie] ; John F. Flaherty [États-Unis] ; Raul Aguilar Schall [États-Unis] ; Robert P. Myers [États-Unis] ; G Mani Subramanian [États-Unis] ; John G. Mchutchison [États-Unis] ; Zobair Younossi [États-Unis] ; Patrick Marcellin [France] ; Keyur Patel [États-Unis]Source :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [ 1542-7714 ] ; 2017.
Abstract
Despite complete suppression of viral DNA with antiviral agents, in some patients with chronic hepatitis B (CHB), serum levels of alanine aminotransferase (ALT) do not normalize. We investigated factors associated with persistent increases in ALT level in patients with CHB given long-term tenofovir disoproxil fumarate.
DOI: 10.1016/j.cgh.2017.01.032
PubMed: 28215615
Affiliations:
- Australie, Bulgarie, Espagne, France, Pologne, Turquie, États-Unis
- Californie, Caroline du Nord, Catalogne, Massachusetts, Sofia-ville (oblast), Tennessee, Virginie, État de New York
- Barcelone, Sofia
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:28215615Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.</title>
<author><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York, New York. Electronic address: ira.jacobson@nyumc.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Washington, Mary K" sort="Washington, Mary K" uniqKey="Washington M" first="Mary K" last="Washington">Mary K. Washington</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name>
<affiliation wicri:level="3"><nlm:affiliation>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Afdhal, Nezam" sort="Afdhal, Nezam" uniqKey="Afdhal N" first="Nezam" last="Afdhal">Nezam Afdhal</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok</wicri:regionArea>
<wicri:noRegion>Bialystok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akarca, Ulus Salih" sort="Akarca, Ulus Salih" uniqKey="Akarca U" first="Ulus Salih" last="Akarca">Ulus Salih Akarca</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir</wicri:regionArea>
<wicri:noRegion>Izmir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tchernev, Konstantin G" sort="Tchernev, Konstantin G" uniqKey="Tchernev K" first="Konstantin G" last="Tchernev">Konstantin G. Tchernev</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Internal Diseases, Medical University, Sofia, Bulgaria.</nlm:affiliation>
<country xml:lang="fr">Bulgarie</country>
<wicri:regionArea>Department of Internal Diseases, Medical University, Sofia</wicri:regionArea>
<placeName><settlement type="city">Sofia</settlement>
<region nuts="2">Sofia-ville (oblast)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Flaherty, John F" sort="Flaherty, John F" uniqKey="Flaherty J" first="John F" last="Flaherty">John F. Flaherty</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aguilar Schall, Raul" sort="Aguilar Schall, Raul" uniqKey="Aguilar Schall R" first="Raul" last="Aguilar Schall">Raul Aguilar Schall</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P" last="Myers">Robert P. Myers</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Younossi, Zobair" sort="Younossi, Zobair" uniqKey="Younossi Z" first="Zobair" last="Younossi">Zobair Younossi</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name>
<affiliation wicri:level="1"><nlm:affiliation>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy</wicri:regionArea>
<wicri:noRegion>Clichy</wicri:noRegion>
<wicri:noRegion>Clichy</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28215615</idno>
<idno type="pmid">28215615</idno>
<idno type="doi">10.1016/j.cgh.2017.01.032</idno>
<idno type="wicri:Area/PubMed/Corpus">000924</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000924</idno>
<idno type="wicri:Area/PubMed/Curation">000921</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000921</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000921</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000921</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.</title>
<author><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York, New York. Electronic address: ira.jacobson@nyumc.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Washington, Mary K" sort="Washington, Mary K" uniqKey="Washington M" first="Mary K" last="Washington">Mary K. Washington</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name>
<affiliation wicri:level="3"><nlm:affiliation>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Afdhal, Nezam" sort="Afdhal, Nezam" uniqKey="Afdhal N" first="Nezam" last="Afdhal">Nezam Afdhal</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok</wicri:regionArea>
<wicri:noRegion>Bialystok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akarca, Ulus Salih" sort="Akarca, Ulus Salih" uniqKey="Akarca U" first="Ulus Salih" last="Akarca">Ulus Salih Akarca</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir</wicri:regionArea>
<wicri:noRegion>Izmir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tchernev, Konstantin G" sort="Tchernev, Konstantin G" uniqKey="Tchernev K" first="Konstantin G" last="Tchernev">Konstantin G. Tchernev</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Internal Diseases, Medical University, Sofia, Bulgaria.</nlm:affiliation>
<country xml:lang="fr">Bulgarie</country>
<wicri:regionArea>Department of Internal Diseases, Medical University, Sofia</wicri:regionArea>
<placeName><settlement type="city">Sofia</settlement>
<region nuts="2">Sofia-ville (oblast)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Flaherty, John F" sort="Flaherty, John F" uniqKey="Flaherty J" first="John F" last="Flaherty">John F. Flaherty</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aguilar Schall, Raul" sort="Aguilar Schall, Raul" uniqKey="Aguilar Schall R" first="Raul" last="Aguilar Schall">Raul Aguilar Schall</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P" last="Myers">Robert P. Myers</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Younossi, Zobair" sort="Younossi, Zobair" uniqKey="Younossi Z" first="Zobair" last="Younossi">Zobair Younossi</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
<wicri:cityArea>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name>
<affiliation wicri:level="1"><nlm:affiliation>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy</wicri:regionArea>
<wicri:noRegion>Clichy</wicri:noRegion>
<wicri:noRegion>Clichy</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</title>
<idno type="eISSN">1542-7714</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Despite complete suppression of viral DNA with antiviral agents, in some patients with chronic hepatitis B (CHB), serum levels of alanine aminotransferase (ALT) do not normalize. We investigated factors associated with persistent increases in ALT level in patients with CHB given long-term tenofovir disoproxil fumarate.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28215615</PMID>
<DateCreated><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateCreated>
<DateRevised><Year>2017</Year>
<Month>06</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1542-7714</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>7</Issue>
<PubDate><Year>2017</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</Title>
<ISOAbbreviation>Clin. Gastroenterol. Hepatol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.</ArticleTitle>
<Pagination><MedlinePgn>1087-1094.e2</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1542-3565(17)30149-0</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cgh.2017.01.032</ELocationID>
<Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Despite complete suppression of viral DNA with antiviral agents, in some patients with chronic hepatitis B (CHB), serum levels of alanine aminotransferase (ALT) do not normalize. We investigated factors associated with persistent increases in ALT level in patients with CHB given long-term tenofovir disoproxil fumarate.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We analyzed data from 471 hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients with CHB participating in 2 phase 3 trials. We identified patients with an increased level of ALT (above the upper limit of normal range) after 5 years (240 weeks) of tenofovir disoproxil fumarate therapy. We analyzed findings from liver biopsy specimens collected from 467 patients (99%) at baseline and 339 patients (72%) at year 5 of treatment; biopsy specimens were evaluated by an independent pathologist. We performed stepwise, forward, multivariate regression analyses of specified baseline characteristics and on-treatment response parameters to identify factors associated with persistent increases in ALT level.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 471 patients, 87 (18%) still had an increased ALT level at year 5 of treatment. Factors associated significantly with a persistent increase in ALT level were a steatosis score of 5% or greater (grade 1 or more) at baseline (odds ratio [OR], 2.236; 95% confidence interval [CI], 1.031-4.852; P = .042) and at year 5 (OR, 3.392; 95% CI, 1.560 ≥ 7.375; P = .002), HBeAg seropositivity at baseline (OR, 3.297; 95% CI, 1.653-6.576; P < .001), and age 40 years or older (OR, 2.099; 95% CI, 1.014-4.342; P = .046). Of the 42 HBeAg-positive patients with steatosis at baseline, 21 (50%) had an increased ALT level at year 5 of treatment. Patients with persistent increases in ALT level were more likely to have an increase in steatosis at year 5 than those with a normal ALT level.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">HBeAg seropositivity and hepatic steatosis contribute to persistent increases in ALT level in patients with CHB receiving suppressive antiviral treatment. ClinicalTrials.gov registration numbers: NCT00117676 and NCT00116805.</AbstractText>
<CopyrightInformation>Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jacobson</LastName>
<ForeName>Ira M</ForeName>
<Initials>IM</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York, New York. Electronic address: ira.jacobson@nyumc.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Washington</LastName>
<ForeName>Mary K</ForeName>
<Initials>MK</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Buti</LastName>
<ForeName>Maria</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thompson</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Afdhal</LastName>
<ForeName>Nezam</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Flisiak</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Akarca</LastName>
<ForeName>Ulus Salih</ForeName>
<Initials>US</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir, Turkey.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tchernev</LastName>
<ForeName>Konstantin G</ForeName>
<Initials>KG</Initials>
<AffiliationInfo><Affiliation>Department of Internal Diseases, Medical University, Sofia, Bulgaria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Flaherty</LastName>
<ForeName>John F</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aguilar Schall</LastName>
<ForeName>Raul</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Myers</LastName>
<ForeName>Robert P</ForeName>
<Initials>RP</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Subramanian</LastName>
<ForeName>G Mani</ForeName>
<Initials>GM</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McHutchison</LastName>
<ForeName>John G</ForeName>
<Initials>JG</Initials>
<AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Younossi</LastName>
<ForeName>Zobair</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marcellin</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Patel</LastName>
<ForeName>Keyur</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>02</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Clin Gastroenterol Hepatol</MedlineTA>
<NlmUniqueID>101160775</NlmUniqueID>
<ISSNLinking>1542-3565</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adiponutrin/Patatin-Like Phospholipase-3</Keyword>
<Keyword MajorTopicYN="N">HBV</Keyword>
<Keyword MajorTopicYN="N">Hepatitis B Virus Infection</Keyword>
<Keyword MajorTopicYN="N">Serum Transaminase</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>08</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>01</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>01</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>2</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>2</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>2</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28215615</ArticleId>
<ArticleId IdType="pii">S1542-3565(17)30149-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.cgh.2017.01.032</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>Bulgarie</li>
<li>Espagne</li>
<li>France</li>
<li>Pologne</li>
<li>Turquie</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Caroline du Nord</li>
<li>Catalogne</li>
<li>Massachusetts</li>
<li>Sofia-ville (oblast)</li>
<li>Tennessee</li>
<li>Virginie</li>
<li>État de New York</li>
</region>
<settlement><li>Barcelone</li>
<li>Sofia</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name>
</region>
<name sortKey="Afdhal, Nezam" sort="Afdhal, Nezam" uniqKey="Afdhal N" first="Nezam" last="Afdhal">Nezam Afdhal</name>
<name sortKey="Aguilar Schall, Raul" sort="Aguilar Schall, Raul" uniqKey="Aguilar Schall R" first="Raul" last="Aguilar Schall">Raul Aguilar Schall</name>
<name sortKey="Flaherty, John F" sort="Flaherty, John F" uniqKey="Flaherty J" first="John F" last="Flaherty">John F. Flaherty</name>
<name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name>
<name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P" last="Myers">Robert P. Myers</name>
<name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name>
<name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name>
<name sortKey="Washington, Mary K" sort="Washington, Mary K" uniqKey="Washington M" first="Mary K" last="Washington">Mary K. Washington</name>
<name sortKey="Younossi, Zobair" sort="Younossi, Zobair" uniqKey="Younossi Z" first="Zobair" last="Younossi">Zobair Younossi</name>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name>
</noRegion>
</country>
<country name="Turquie"><noRegion><name sortKey="Akarca, Ulus Salih" sort="Akarca, Ulus Salih" uniqKey="Akarca U" first="Ulus Salih" last="Akarca">Ulus Salih Akarca</name>
</noRegion>
</country>
<country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Tchernev, Konstantin G" sort="Tchernev, Konstantin G" uniqKey="Tchernev K" first="Konstantin G" last="Tchernev">Konstantin G. Tchernev</name>
</region>
</country>
<country name="France"><noRegion><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C42 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000C42 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:28215615 |texte= Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:28215615" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |