Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.
Identifieur interne : 000C42 ( PubMed/Checkpoint ); précédent : 000C41; suivant : 000C43Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.
Auteurs : Ira M. Jacobson [États-Unis] ; Mary K. Washington [États-Unis] ; Maria Buti [Espagne] ; Alexander Thompson [Australie] ; Nezam Afdhal [États-Unis] ; Robert Flisiak [Pologne] ; Ulus Salih Akarca [Turquie] ; Konstantin G. Tchernev [Bulgarie] ; John F. Flaherty [États-Unis] ; Raul Aguilar Schall [États-Unis] ; Robert P. Myers [États-Unis] ; G Mani Subramanian [États-Unis] ; John G. Mchutchison [États-Unis] ; Zobair Younossi [États-Unis] ; Patrick Marcellin [France] ; Keyur Patel [États-Unis]Source :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [ 1542-7714 ] ; 2017.
Abstract
Despite complete suppression of viral DNA with antiviral agents, in some patients with chronic hepatitis B (CHB), serum levels of alanine aminotransferase (ALT) do not normalize. We investigated factors associated with persistent increases in ALT level in patients with CHB given long-term tenofovir disoproxil fumarate.
DOI: 10.1016/j.cgh.2017.01.032
PubMed: 28215615
Affiliations:
- Australie, Bulgarie, Espagne, France, Pologne, Turquie, États-Unis
- Californie, Caroline du Nord, Catalogne, Massachusetts, Sofia-ville (oblast), Tennessee, Virginie, État de New York
- Barcelone, Sofia
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Tchernev</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Diseases, Medical University, Sofia, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Internal Diseases, Medical University, Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Flaherty, John F" sort="Flaherty, John F" uniqKey="Flaherty J" first="John F" last="Flaherty">John F. Flaherty</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Aguilar Schall, Raul" sort="Aguilar Schall, Raul" uniqKey="Aguilar Schall R" first="Raul" last="Aguilar Schall">Raul Aguilar Schall</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P" last="Myers">Robert P. 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Mchutchison</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Younossi, Zobair" sort="Younossi, Zobair" uniqKey="Younossi Z" first="Zobair" last="Younossi">Zobair Younossi</name><affiliation wicri:level="2"><nlm:affiliation>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church</wicri:cityArea></affiliation></author><author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name><affiliation wicri:level="1"><nlm:affiliation>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy</wicri:regionArea><wicri:noRegion>Clichy</wicri:noRegion><wicri:noRegion>Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28215615</idno><idno type="pmid">28215615</idno><idno type="doi">10.1016/j.cgh.2017.01.032</idno><idno type="wicri:Area/PubMed/Corpus">000924</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000924</idno><idno type="wicri:Area/PubMed/Curation">000921</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000921</idno><idno type="wicri:Area/PubMed/Checkpoint">000921</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000921</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.</title><author><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York, New York. Electronic address: ira.jacobson@nyumc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Washington, Mary K" sort="Washington, Mary K" uniqKey="Washington M" first="Mary K" last="Washington">Mary K. Washington</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name><affiliation wicri:level="3"><nlm:affiliation>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Afdhal, Nezam" sort="Afdhal, Nezam" uniqKey="Afdhal N" first="Nezam" last="Afdhal">Nezam Afdhal</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Akarca, Ulus Salih" sort="Akarca, Ulus Salih" uniqKey="Akarca U" first="Ulus Salih" last="Akarca">Ulus Salih Akarca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir</wicri:regionArea><wicri:noRegion>Izmir</wicri:noRegion></affiliation></author><author><name sortKey="Tchernev, Konstantin G" sort="Tchernev, Konstantin G" uniqKey="Tchernev K" first="Konstantin G" last="Tchernev">Konstantin G. Tchernev</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Diseases, Medical University, Sofia, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Internal Diseases, Medical University, Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Flaherty, John F" sort="Flaherty, John F" uniqKey="Flaherty J" first="John F" last="Flaherty">John F. Flaherty</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Aguilar Schall, Raul" sort="Aguilar Schall, Raul" uniqKey="Aguilar Schall R" first="Raul" last="Aguilar Schall">Raul Aguilar Schall</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P" last="Myers">Robert P. Myers</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Younossi, Zobair" sort="Younossi, Zobair" uniqKey="Younossi Z" first="Zobair" last="Younossi">Zobair Younossi</name><affiliation wicri:level="2"><nlm:affiliation>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church</wicri:cityArea></affiliation></author><author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name><affiliation wicri:level="1"><nlm:affiliation>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy</wicri:regionArea><wicri:noRegion>Clichy</wicri:noRegion><wicri:noRegion>Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</title><idno type="eISSN">1542-7714</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite complete suppression of viral DNA with antiviral agents, in some patients with chronic hepatitis B (CHB), serum levels of alanine aminotransferase (ALT) do not normalize. We investigated factors associated with persistent increases in ALT level in patients with CHB given long-term tenofovir disoproxil fumarate.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28215615</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>20</Day></DateCreated><DateRevised><Year>2017</Year><Month>06</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1542-7714</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>7</Issue><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</Title><ISOAbbreviation>Clin. Gastroenterol. Hepatol.</ISOAbbreviation></Journal><ArticleTitle>Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.</ArticleTitle><Pagination><MedlinePgn>1087-1094.e2</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1542-3565(17)30149-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cgh.2017.01.032</ELocationID><Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Despite complete suppression of viral DNA with antiviral agents, in some patients with chronic hepatitis B (CHB), serum levels of alanine aminotransferase (ALT) do not normalize. We investigated factors associated with persistent increases in ALT level in patients with CHB given long-term tenofovir disoproxil fumarate.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We analyzed data from 471 hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients with CHB participating in 2 phase 3 trials. We identified patients with an increased level of ALT (above the upper limit of normal range) after 5 years (240 weeks) of tenofovir disoproxil fumarate therapy. We analyzed findings from liver biopsy specimens collected from 467 patients (99%) at baseline and 339 patients (72%) at year 5 of treatment; biopsy specimens were evaluated by an independent pathologist. We performed stepwise, forward, multivariate regression analyses of specified baseline characteristics and on-treatment response parameters to identify factors associated with persistent increases in ALT level.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 471 patients, 87 (18%) still had an increased ALT level at year 5 of treatment. Factors associated significantly with a persistent increase in ALT level were a steatosis score of 5% or greater (grade 1 or more) at baseline (odds ratio [OR], 2.236; 95% confidence interval [CI], 1.031-4.852; P = .042) and at year 5 (OR, 3.392; 95% CI, 1.560 ≥ 7.375; P = .002), HBeAg seropositivity at baseline (OR, 3.297; 95% CI, 1.653-6.576; P < .001), and age 40 years or older (OR, 2.099; 95% CI, 1.014-4.342; P = .046). Of the 42 HBeAg-positive patients with steatosis at baseline, 21 (50%) had an increased ALT level at year 5 of treatment. Patients with persistent increases in ALT level were more likely to have an increase in steatosis at year 5 than those with a normal ALT level.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">HBeAg seropositivity and hepatic steatosis contribute to persistent increases in ALT level in patients with CHB receiving suppressive antiviral treatment. ClinicalTrials.gov registration numbers: NCT00117676 and NCT00116805.</AbstractText><CopyrightInformation>Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jacobson</LastName><ForeName>Ira M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York, New York. Electronic address: ira.jacobson@nyumc.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Washington</LastName><ForeName>Mary K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buti</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Afdhal</LastName><ForeName>Nezam</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flisiak</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akarca</LastName><ForeName>Ulus Salih</ForeName><Initials>US</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tchernev</LastName><ForeName>Konstantin G</ForeName><Initials>KG</Initials><AffiliationInfo><Affiliation>Department of Internal Diseases, Medical University, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flaherty</LastName><ForeName>John F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aguilar Schall</LastName><ForeName>Raul</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Myers</LastName><ForeName>Robert P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Subramanian</LastName><ForeName>G Mani</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McHutchison</LastName><ForeName>John G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Younossi</LastName><ForeName>Zobair</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcellin</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Keyur</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Gastroenterol Hepatol</MedlineTA><NlmUniqueID>101160775</NlmUniqueID><ISSNLinking>1542-3565</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adiponutrin/Patatin-Like Phospholipase-3</Keyword><Keyword MajorTopicYN="N">HBV</Keyword><Keyword MajorTopicYN="N">Hepatitis B Virus Infection</Keyword><Keyword MajorTopicYN="N">Serum Transaminase</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>01</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28215615</ArticleId><ArticleId IdType="pii">S1542-3565(17)30149-0</ArticleId><ArticleId IdType="doi">10.1016/j.cgh.2017.01.032</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Bulgarie</li><li>Espagne</li><li>France</li><li>Pologne</li><li>Turquie</li><li>États-Unis</li></country><region><li>Californie</li><li>Caroline du Nord</li><li>Catalogne</li><li>Massachusetts</li><li>Sofia-ville (oblast)</li><li>Tennessee</li><li>Virginie</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Sofia</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name></region><name sortKey="Afdhal, Nezam" sort="Afdhal, Nezam" uniqKey="Afdhal N" first="Nezam" last="Afdhal">Nezam Afdhal</name><name sortKey="Aguilar Schall, Raul" sort="Aguilar Schall, Raul" uniqKey="Aguilar Schall R" first="Raul" last="Aguilar Schall">Raul Aguilar Schall</name><name sortKey="Flaherty, John F" sort="Flaherty, John F" uniqKey="Flaherty J" first="John F" last="Flaherty">John F. Flaherty</name><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P" last="Myers">Robert P. Myers</name><name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name><name sortKey="Washington, Mary K" sort="Washington, Mary K" uniqKey="Washington M" first="Mary K" last="Washington">Mary K. Washington</name><name sortKey="Younossi, Zobair" sort="Younossi, Zobair" uniqKey="Younossi Z" first="Zobair" last="Younossi">Zobair Younossi</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name></region></country><country name="Australie"><noRegion><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name></noRegion></country><country name="Turquie"><noRegion><name sortKey="Akarca, Ulus Salih" sort="Akarca, Ulus Salih" uniqKey="Akarca U" first="Ulus Salih" last="Akarca">Ulus Salih Akarca</name></noRegion></country><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Tchernev, Konstantin G" sort="Tchernev, Konstantin G" uniqKey="Tchernev K" first="Konstantin G" last="Tchernev">Konstantin G. Tchernev</name></region></country><country name="France"><noRegion><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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