Genetic variability of the activity of bidirectional promoters: a pilot study in bovine muscle.
Identifieur interne : 000B78 ( PubMed/Checkpoint ); précédent : 000B77; suivant : 000B79Genetic variability of the activity of bidirectional promoters: a pilot study in bovine muscle.
Auteurs : Cédric Meersseman [France] ; Rabia Letaief [France] ; Véronique Léjard [France] ; Emmanuelle Rebours [France] ; Gabriel Guillocheau [France] ; Diane Esquerré [France] ; Anis Djari [France] ; Amanda Chamberlain [Australie] ; Christy Vander Jagt [Australie] ; Christophe Klopp [France] ; Mekki Boussaha [France] ; Gilles Renand [France] ; Abderrahman Maftah [France] ; Daniel Petit [France] ; Dominique Rocha [France]Source :
- DNA research : an international journal for rapid publication of reports on genes and genomes [ 1756-1663 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Proteins.
- metabolism : Back Muscles.
- Animals, Cattle, Gene Expression Profiling, Gene Expression Regulation, Male, Pilot Projects, Polymorphism, Single Nucleotide, Promoter Regions, Genetic.
Abstract
Bidirectional promoters are regulatory regions co-regulating the expression of two neighbouring genes organized in a head-to-head orientation. In recent years, these regulatory regions have been studied in many organisms; however, no investigation to date has been done to analyse the genetic variation of the activity of this type of promoter regions. In our study, we conducted an investigation to first identify bidirectional promoters sharing genes expressed in bovine Longissimus thoracis and then to find genetic variants affecting the activity of some of these bidirectional promoters. Combining bovine gene information and expression data obtained using RNA-Seq, we identified 120 putative bidirectional promoters active in bovine muscle. We experimentally validated in vitro 16 of these bidirectional promoters. Finally, using gene expression and whole-genome genotyping data, we explored the variability of the activity in muscle of the identified bidirectional promoters and discovered genetic variants affecting their activity. We found that the expression level of 77 genes is correlated with the activity of 12 bidirectional promoters. We also identified 57 single nucleotide polymorphisms associated with the activity of 5 bidirectional promoters. To our knowledge, our study is the first analysis in any species of the genetic variability of the activity of bidirectional promoters.
DOI: 10.1093/dnares/dsx004
PubMed: 28338730
Affiliations:
- Australie, France
- Limousin, Midi-Pyrénées, Occitanie (région administrative), Île-de-France
- Castanet Tolosan, Castanet-Tolosan, Jouy-en-Josas, Limoges
- Université de Limoges
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pubmed:28338730Le document en format XML
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Jouy-en-Josas</wicri:noRegion></affiliation></author><author><name sortKey="Esquerre, Diane" sort="Esquerre, Diane" uniqKey="Esquerre D" first="Diane" last="Esquerré">Diane Esquerré</name><affiliation wicri:level="1"><nlm:affiliation>GenPhySE, Université de Toulouse, INRA, INPT, ENVT, 31326 Castanet Tolosan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GenPhySE, Université de Toulouse, INRA, INPT, ENVT, 31326 Castanet Tolosan</wicri:regionArea><wicri:noRegion>31326 Castanet Tolosan</wicri:noRegion><wicri:noRegion>31326 Castanet Tolosan</wicri:noRegion></affiliation></author><author><name sortKey="Djari, Anis" sort="Djari, Anis" uniqKey="Djari A" first="Anis" last="Djari">Anis Djari</name><affiliation wicri:level="1"><nlm:affiliation>SIGENAE, UR 875, INRA, 31362 Castanet-Tolosan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>SIGENAE, UR 875, INRA, 31362 Castanet-Tolosan</wicri:regionArea><wicri:noRegion>31362 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Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GMA, INRA, Université de Limoges, 87060 Limoges</wicri:regionArea><wicri:noRegion>87060 Limoges</wicri:noRegion><orgName type="university">Université de Limoges</orgName><placeName><settlement type="city">Limoges</settlement><region type="region" nuts="2">Limousin</region></placeName></affiliation></author><author><name sortKey="Petit, Daniel" sort="Petit, Daniel" uniqKey="Petit D" first="Daniel" last="Petit">Daniel Petit</name><affiliation wicri:level="4"><nlm:affiliation>GMA, INRA, Université de Limoges, 87060 Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GMA, INRA, Université de Limoges, 87060 Limoges</wicri:regionArea><wicri:noRegion>87060 Limoges</wicri:noRegion><orgName type="university">Université de Limoges</orgName><placeName><settlement type="city">Limoges</settlement><region type="region" 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type="city">Jouy-en-Josas</settlement></placeName></affiliation></author><author><name sortKey="Letaief, Rabia" sort="Letaief, Rabia" uniqKey="Letaief R" first="Rabia" last="Letaief">Rabia Letaief</name><affiliation wicri:level="3"><nlm:affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Jouy-en-Josas</settlement></placeName></affiliation></author><author><name sortKey="Lejard, Veronique" sort="Lejard, Veronique" uniqKey="Lejard V" first="Véronique" last="Léjard">Véronique Léjard</name><affiliation wicri:level="3"><nlm:affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Jouy-en-Josas</settlement></placeName></affiliation></author><author><name sortKey="Rebours, Emmanuelle" sort="Rebours, Emmanuelle" uniqKey="Rebours E" first="Emmanuelle" last="Rebours">Emmanuelle Rebours</name><affiliation wicri:level="3"><nlm:affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Jouy-en-Josas</settlement></placeName></affiliation></author><author><name sortKey="Guillocheau, Gabriel" sort="Guillocheau, Gabriel" uniqKey="Guillocheau G" first="Gabriel" last="Guillocheau">Gabriel Guillocheau</name><affiliation wicri:level="3"><nlm:affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Jouy-en-Josas</settlement></placeName></affiliation></author><author><name sortKey="Esquerre, Diane" sort="Esquerre, Diane" uniqKey="Esquerre D" first="Diane" last="Esquerré">Diane Esquerré</name><affiliation wicri:level="3"><nlm:affiliation>GenPhySE, Université de Toulouse, INRA, INPT, ENVT, 31326 Castanet Tolosan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GenPhySE, Université de Toulouse, INRA, INPT, ENVT, 31326 Castanet Tolosan</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Castanet Tolosan</settlement></placeName></affiliation></author><author><name sortKey="Djari, Anis" sort="Djari, Anis" uniqKey="Djari A" first="Anis" last="Djari">Anis Djari</name><affiliation wicri:level="3"><nlm:affiliation>SIGENAE, UR 875, INRA, 31362 Castanet-Tolosan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>SIGENAE, UR 875, INRA, 31362 Castanet-Tolosan</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Castanet-Tolosan</settlement></placeName></affiliation></author><author><name sortKey="Chamberlain, Amanda" sort="Chamberlain, Amanda" uniqKey="Chamberlain A" first="Amanda" last="Chamberlain">Amanda Chamberlain</name><affiliation wicri:level="1"><nlm:affiliation>Dairy Futures Cooperative Research Centre, AgriBio, Bundoora, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Dairy Futures Cooperative Research Centre, AgriBio, Bundoora, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Vander Jagt, Christy" sort="Vander Jagt, Christy" uniqKey="Vander Jagt C" first="Christy" last="Vander Jagt">Christy Vander Jagt</name><affiliation wicri:level="1"><nlm:affiliation>Dairy Futures Cooperative Research Centre, AgriBio, Bundoora, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Dairy Futures Cooperative Research Centre, AgriBio, Bundoora, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Klopp, Christophe" sort="Klopp, Christophe" uniqKey="Klopp C" first="Christophe" last="Klopp">Christophe Klopp</name><affiliation wicri:level="1"><nlm:affiliation>SIGENAE, UR 875, INRA, 31362 Castanet-Tolosan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>SIGENAE, UR 875, INRA, 31362 Castanet-Tolosan</wicri:regionArea><wicri:noRegion>31362 Castanet-Tolosan</wicri:noRegion><wicri:noRegion>31362 Castanet-Tolosan</wicri:noRegion></affiliation></author><author><name sortKey="Boussaha, Mekki" sort="Boussaha, Mekki" uniqKey="Boussaha M" first="Mekki" last="Boussaha">Mekki Boussaha</name><affiliation wicri:level="1"><nlm:affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas</wicri:regionArea><wicri:noRegion>78350 Jouy-en-Josas</wicri:noRegion><wicri:noRegion>78350 Jouy-en-Josas</wicri:noRegion></affiliation></author><author><name sortKey="Renand, Gilles" sort="Renand, Gilles" uniqKey="Renand G" first="Gilles" last="Renand">Gilles Renand</name><affiliation wicri:level="1"><nlm:affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas</wicri:regionArea><wicri:noRegion>78350 Jouy-en-Josas</wicri:noRegion><wicri:noRegion>78350 Jouy-en-Josas</wicri:noRegion></affiliation></author><author><name sortKey="Maftah, Abderrahman" sort="Maftah, Abderrahman" uniqKey="Maftah A" first="Abderrahman" last="Maftah">Abderrahman Maftah</name><affiliation wicri:level="4"><nlm:affiliation>GMA, INRA, Université de Limoges, 87060 Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GMA, INRA, Université de Limoges, 87060 Limoges</wicri:regionArea><wicri:noRegion>87060 Limoges</wicri:noRegion><orgName type="university">Université de Limoges</orgName><placeName><settlement type="city">Limoges</settlement><region type="region" nuts="2">Limousin</region></placeName></affiliation></author><author><name sortKey="Petit, Daniel" sort="Petit, Daniel" uniqKey="Petit D" first="Daniel" last="Petit">Daniel Petit</name><affiliation wicri:level="4"><nlm:affiliation>GMA, INRA, Université de Limoges, 87060 Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GMA, INRA, Université de Limoges, 87060 Limoges</wicri:regionArea><wicri:noRegion>87060 Limoges</wicri:noRegion><orgName type="university">Université de Limoges</orgName><placeName><settlement type="city">Limoges</settlement><region type="region" nuts="2">Limousin</region></placeName></affiliation></author><author><name sortKey="Rocha, Dominique" sort="Rocha, Dominique" uniqKey="Rocha D" first="Dominique" last="Rocha">Dominique Rocha</name><affiliation wicri:level="1"><nlm:affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas</wicri:regionArea><wicri:noRegion>78350 Jouy-en-Josas</wicri:noRegion><wicri:noRegion>78350 Jouy-en-Josas</wicri:noRegion></affiliation></author></analytic><series><title level="j">DNA research : an international journal for rapid publication of reports on genes and genomes</title><idno type="eISSN">1756-1663</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Back Muscles (metabolism)</term><term>Cattle</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Male</term><term>Pilot Projects</term><term>Polymorphism, Single Nucleotide</term><term>Promoter Regions, Genetic</term><term>Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Bovins</term><term>Muscles du dos (métabolisme)</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Projets pilotes</term><term>Protéines (génétique)</term><term>Régions promotrices (génétique)</term><term>Régulation de l'expression des gènes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Back Muscles</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Muscles du dos</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cattle</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Male</term><term>Pilot Projects</term><term>Polymorphism, Single Nucleotide</term><term>Promoter Regions, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Bovins</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Projets pilotes</term><term>Régions promotrices (génétique)</term><term>Régulation de l'expression des gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bidirectional promoters are regulatory regions co-regulating the expression of two neighbouring genes organized in a head-to-head orientation. In recent years, these regulatory regions have been studied in many organisms; however, no investigation to date has been done to analyse the genetic variation of the activity of this type of promoter regions. In our study, we conducted an investigation to first identify bidirectional promoters sharing genes expressed in bovine Longissimus thoracis and then to find genetic variants affecting the activity of some of these bidirectional promoters. Combining bovine gene information and expression data obtained using RNA-Seq, we identified 120 putative bidirectional promoters active in bovine muscle. We experimentally validated in vitro 16 of these bidirectional promoters. Finally, using gene expression and whole-genome genotyping data, we explored the variability of the activity in muscle of the identified bidirectional promoters and discovered genetic variants affecting their activity. We found that the expression level of 77 genes is correlated with the activity of 12 bidirectional promoters. We also identified 57 single nucleotide polymorphisms associated with the activity of 5 bidirectional promoters. To our knowledge, our study is the first analysis in any species of the genetic variability of the activity of bidirectional promoters.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28338730</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>24</Day></DateCreated><DateCompleted><Year>2017</Year><Month>08</Month><Day>07</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1756-1663</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>DNA research : an international journal for rapid publication of reports on genes and genomes</Title><ISOAbbreviation>DNA Res.</ISOAbbreviation></Journal><ArticleTitle>Genetic variability of the activity of bidirectional promoters: a pilot study in bovine muscle.</ArticleTitle><Pagination><MedlinePgn>221-233</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/dnares/dsx004</ELocationID><Abstract><AbstractText>Bidirectional promoters are regulatory regions co-regulating the expression of two neighbouring genes organized in a head-to-head orientation. In recent years, these regulatory regions have been studied in many organisms; however, no investigation to date has been done to analyse the genetic variation of the activity of this type of promoter regions. In our study, we conducted an investigation to first identify bidirectional promoters sharing genes expressed in bovine Longissimus thoracis and then to find genetic variants affecting the activity of some of these bidirectional promoters. Combining bovine gene information and expression data obtained using RNA-Seq, we identified 120 putative bidirectional promoters active in bovine muscle. We experimentally validated in vitro 16 of these bidirectional promoters. Finally, using gene expression and whole-genome genotyping data, we explored the variability of the activity in muscle of the identified bidirectional promoters and discovered genetic variants affecting their activity. We found that the expression level of 77 genes is correlated with the activity of 12 bidirectional promoters. We also identified 57 single nucleotide polymorphisms associated with the activity of 5 bidirectional promoters. To our knowledge, our study is the first analysis in any species of the genetic variability of the activity of bidirectional promoters.</AbstractText><CopyrightInformation>© The Author 2017. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Meersseman</LastName><ForeName>Cédric</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>GMA, INRA, Université de Limoges, 87060 Limoges, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Letaief</LastName><ForeName>Rabia</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Léjard</LastName><ForeName>Véronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rebours</LastName><ForeName>Emmanuelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guillocheau</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esquerré</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>GenPhySE, Université de Toulouse, INRA, INPT, ENVT, 31326 Castanet Tolosan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djari</LastName><ForeName>Anis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>SIGENAE, UR 875, INRA, 31362 Castanet-Tolosan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chamberlain</LastName><ForeName>Amanda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Dairy Futures Cooperative Research Centre, AgriBio, Bundoora, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AgriBio, Department of Economic Development, Jobs, Transport & Resources, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vander Jagt</LastName><ForeName>Christy</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Dairy Futures Cooperative Research Centre, AgriBio, Bundoora, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AgriBio, Department of Economic Development, Jobs, Transport & Resources, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klopp</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>SIGENAE, UR 875, INRA, 31362 Castanet-Tolosan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boussaha</LastName><ForeName>Mekki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Renand</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maftah</LastName><ForeName>Abderrahman</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>GMA, INRA, Université de Limoges, 87060 Limoges, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petit</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>GMA, INRA, Université de Limoges, 87060 Limoges, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rocha</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>DNA Res</MedlineTA><NlmUniqueID>9423827</NlmUniqueID><ISSNLinking>1340-2838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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Version="1">24361965</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Comput Biol. 2006 Jul 7;2(7):e74</RefSource><PMID Version="1">16839196</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2008 May 28;9 Suppl 6:S9</RefSource><PMID Version="1">18541062</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2005 Jan 1;33(Database issue):D112-5</RefSource><PMID Version="1">15608158</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064131" MajorTopicYN="N">Back Muscles</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="Y">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="Y">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011401" MajorTopicYN="Y">Promoter Regions, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011506" MajorTopicYN="N">Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bidirectional promoter</Keyword><Keyword MajorTopicYN="N">cattle genome</Keyword><Keyword MajorTopicYN="N">genetic variability</Keyword><Keyword MajorTopicYN="N">muscle</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28338730</ArticleId><ArticleId IdType="pii">3052238</ArticleId><ArticleId IdType="doi">10.1093/dnares/dsx004</ArticleId><ArticleId IdType="pmc">PMC5499805</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Limousin</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Île-de-France</li></region><settlement><li>Castanet Tolosan</li><li>Castanet-Tolosan</li><li>Jouy-en-Josas</li><li>Limoges</li></settlement><orgName><li>Université de Limoges</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Meersseman, Cedric" sort="Meersseman, Cedric" uniqKey="Meersseman C" first="Cédric" last="Meersseman">Cédric Meersseman</name></region><name sortKey="Boussaha, Mekki" sort="Boussaha, Mekki" uniqKey="Boussaha M" first="Mekki" last="Boussaha">Mekki Boussaha</name><name sortKey="Djari, Anis" sort="Djari, Anis" uniqKey="Djari A" first="Anis" last="Djari">Anis Djari</name><name sortKey="Esquerre, Diane" sort="Esquerre, Diane" uniqKey="Esquerre D" first="Diane" last="Esquerré">Diane Esquerré</name><name sortKey="Guillocheau, Gabriel" sort="Guillocheau, Gabriel" uniqKey="Guillocheau G" first="Gabriel" last="Guillocheau">Gabriel Guillocheau</name><name sortKey="Klopp, Christophe" sort="Klopp, Christophe" uniqKey="Klopp C" first="Christophe" last="Klopp">Christophe Klopp</name><name sortKey="Lejard, Veronique" sort="Lejard, Veronique" uniqKey="Lejard V" first="Véronique" last="Léjard">Véronique Léjard</name><name sortKey="Letaief, Rabia" sort="Letaief, Rabia" uniqKey="Letaief R" first="Rabia" last="Letaief">Rabia Letaief</name><name sortKey="Maftah, Abderrahman" sort="Maftah, Abderrahman" uniqKey="Maftah A" first="Abderrahman" last="Maftah">Abderrahman Maftah</name><name sortKey="Petit, Daniel" sort="Petit, Daniel" uniqKey="Petit D" first="Daniel" last="Petit">Daniel Petit</name><name sortKey="Rebours, Emmanuelle" sort="Rebours, Emmanuelle" uniqKey="Rebours E" first="Emmanuelle" last="Rebours">Emmanuelle Rebours</name><name sortKey="Renand, Gilles" sort="Renand, Gilles" uniqKey="Renand G" first="Gilles" last="Renand">Gilles Renand</name><name sortKey="Rocha, Dominique" sort="Rocha, Dominique" uniqKey="Rocha D" first="Dominique" last="Rocha">Dominique Rocha</name></country><country name="Australie"><noRegion><name sortKey="Chamberlain, Amanda" sort="Chamberlain, Amanda" uniqKey="Chamberlain A" first="Amanda" last="Chamberlain">Amanda Chamberlain</name></noRegion><name sortKey="Vander Jagt, Christy" sort="Vander Jagt, Christy" uniqKey="Vander Jagt C" first="Christy" last="Vander Jagt">Christy Vander Jagt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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