Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.
Identifieur interne : 000A59 ( PubMed/Checkpoint ); précédent : 000A58; suivant : 000A60Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.
Auteurs : Ruth O. Payne [Royaume-Uni] ; Sarah E. Silk [Royaume-Uni] ; Sean C. Elias [Royaume-Uni] ; Kathryn H. Milne [Royaume-Uni] ; Thomas A. Rawlinson [Royaume-Uni] ; David Llewellyn [Royaume-Uni] ; A Rushdi Shakri [Inde] ; Jing Jin [Royaume-Uni] ; Geneviève M. Labbé [Royaume-Uni] ; Nick J. Edwards [Royaume-Uni] ; Ian D. Poulton [Royaume-Uni] ; Rachel Roberts [Royaume-Uni] ; Ryan Farid [Australie] ; Thomas J Rgensen [Danemark] ; Daniel Gw Alanine [Royaume-Uni] ; Simone C. De Cassan [Royaume-Uni] ; Matthew K. Higgins [Royaume-Uni] ; Thomas D. Otto [Royaume-Uni] ; James S. Mccarthy [Australie] ; Willem A. De Jongh [Danemark] ; Alfredo Nicosia [Italie] ; Sarah Moyle [Royaume-Uni] ; Adrian Vs Hill [Royaume-Uni] ; Eleanor Berrie [Royaume-Uni] ; Chetan E. Chitnis [Inde] ; Alison M. Lawrie [Royaume-Uni] ; Simon J. Draper [Royaume-Uni]Source :
- JCI insight [ 2379-3708 ] ; 2017.
Abstract
Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with clinical immunity, but it is unknown whether these responses can be induced by human vaccination.
DOI: 10.1172/jci.insight.93683
PubMed: 28614791
Affiliations:
- Australie, Danemark, Inde, Italie, Royaume-Uni
- Angleterre, Latium, Oxfordshire
- Oxford, Rome
- Université d'Oxford
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Chitnis</name><affiliation wicri:level="1"><nlm:affiliation>International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Lawrie, Alison M" sort="Lawrie, Alison M" uniqKey="Lawrie A" first="Alison M" last="Lawrie">Alison M. Lawrie</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Draper, Simon J" sort="Draper, Simon J" uniqKey="Draper S" first="Simon J" last="Draper">Simon J. Draper</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28614791</idno><idno type="pmid">28614791</idno><idno type="doi">10.1172/jci.insight.93683</idno><idno type="wicri:Area/PubMed/Corpus">000B07</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B07</idno><idno type="wicri:Area/PubMed/Curation">000B04</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B04</idno><idno type="wicri:Area/PubMed/Checkpoint">000B04</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.</title><author><name sortKey="Payne, Ruth O" sort="Payne, Ruth O" uniqKey="Payne R" first="Ruth O" last="Payne">Ruth O. Payne</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Silk, Sarah E" sort="Silk, Sarah E" uniqKey="Silk S" first="Sarah E" last="Silk">Sarah E. Silk</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Elias, Sean C" sort="Elias, Sean C" uniqKey="Elias S" first="Sean C" last="Elias">Sean C. Elias</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Milne, Kathryn H" sort="Milne, Kathryn H" uniqKey="Milne K" first="Kathryn H" last="Milne">Kathryn H. Milne</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Rawlinson, Thomas A" sort="Rawlinson, Thomas A" uniqKey="Rawlinson T" first="Thomas A" last="Rawlinson">Thomas A. Rawlinson</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Llewellyn, David" sort="Llewellyn, David" uniqKey="Llewellyn D" first="David" last="Llewellyn">David Llewellyn</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Shakri, A Rushdi" sort="Shakri, A Rushdi" uniqKey="Shakri A" first="A Rushdi" last="Shakri">A Rushdi Shakri</name><affiliation wicri:level="1"><nlm:affiliation>International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Jing" sort="Jin, Jing" uniqKey="Jin J" first="Jing" last="Jin">Jing Jin</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Labbe, Genevieve M" sort="Labbe, Genevieve M" uniqKey="Labbe G" first="Geneviève M" last="Labbé">Geneviève M. Labbé</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Edwards, Nick J" sort="Edwards, Nick J" uniqKey="Edwards N" first="Nick J" last="Edwards">Nick J. Edwards</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Poulton, Ian D" sort="Poulton, Ian D" uniqKey="Poulton I" first="Ian D" last="Poulton">Ian D. Poulton</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Roberts, Rachel" sort="Roberts, Rachel" uniqKey="Roberts R" first="Rachel" last="Roberts">Rachel Roberts</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Farid, Ryan" sort="Farid, Ryan" uniqKey="Farid R" first="Ryan" last="Farid">Ryan Farid</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="J Rgensen, Thomas" sort="J Rgensen, Thomas" uniqKey="J Rgensen T" first="Thomas" last="J Rgensen">Thomas J Rgensen</name><affiliation wicri:level="1"><nlm:affiliation>ExpreS2, ion Biotechnologies, SCION-DTU Science Park, Hørsholm, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>ExpreS2, ion Biotechnologies, SCION-DTU Science Park, Hørsholm</wicri:regionArea><wicri:noRegion>Hørsholm</wicri:noRegion></affiliation></author><author><name sortKey="Alanine, Daniel Gw" sort="Alanine, Daniel Gw" uniqKey="Alanine D" first="Daniel Gw" last="Alanine">Daniel Gw Alanine</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="De Cassan, Simone C" sort="De Cassan, Simone C" uniqKey="De Cassan S" first="Simone C" last="De Cassan">Simone C. De Cassan</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Higgins, Matthew K" sort="Higgins, Matthew K" uniqKey="Higgins M" first="Matthew K" last="Higgins">Matthew K. Higgins</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biochemistry, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. Otto</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mccarthy, James S" sort="Mccarthy, James S" uniqKey="Mccarthy J" first="James S" last="Mccarthy">James S. Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="De Jongh, Willem A" sort="De Jongh, Willem A" uniqKey="De Jongh W" first="Willem A" last="De Jongh">Willem A. De Jongh</name><affiliation wicri:level="1"><nlm:affiliation>ExpreS2, ion Biotechnologies, SCION-DTU Science Park, Hørsholm, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>ExpreS2, ion Biotechnologies, SCION-DTU Science Park, Hørsholm</wicri:regionArea><wicri:noRegion>Hørsholm</wicri:noRegion></affiliation></author><author><name sortKey="Nicosia, Alfredo" sort="Nicosia, Alfredo" uniqKey="Nicosia A" first="Alfredo" last="Nicosia">Alfredo Nicosia</name><affiliation wicri:level="3"><nlm:affiliation>ReiThera SRL (formerly Okairòs SRL), Viale Città d'Europa, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ReiThera SRL (formerly Okairòs SRL), Viale Città d'Europa, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Moyle, Sarah" sort="Moyle, Sarah" uniqKey="Moyle S" first="Sarah" last="Moyle">Sarah Moyle</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Biomanufacturing Facility, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Biomanufacturing Facility, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Hill, Adrian Vs" sort="Hill, Adrian Vs" uniqKey="Hill A" first="Adrian Vs" last="Hill">Adrian Vs Hill</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Berrie, Eleanor" sort="Berrie, Eleanor" uniqKey="Berrie E" first="Eleanor" last="Berrie">Eleanor Berrie</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Biomanufacturing Facility, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Biomanufacturing Facility, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Chitnis, Chetan E" sort="Chitnis, Chetan E" uniqKey="Chitnis C" first="Chetan E" last="Chitnis">Chetan E. Chitnis</name><affiliation wicri:level="1"><nlm:affiliation>International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Lawrie, Alison M" sort="Lawrie, Alison M" uniqKey="Lawrie A" first="Alison M" last="Lawrie">Alison M. Lawrie</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Draper, Simon J" sort="Draper, Simon J" uniqKey="Draper S" first="Simon J" last="Draper">Simon J. Draper</name><affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Jenner Institute, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></analytic><series><title level="j">JCI insight</title><idno type="eISSN">2379-3708</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with clinical immunity, but it is unknown whether these responses can be induced by human vaccination.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28614791</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>14</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2379-3708</ISSN><JournalIssue CitedMedium="Internet"><Volume>2</Volume><Issue>12</Issue><PubDate><Year>2017</Year><Month>Jun</Month><Day>15</Day></PubDate></JournalIssue><Title>JCI insight</Title><ISOAbbreviation>JCI Insight</ISOAbbreviation></Journal><ArticleTitle>Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1172/jci.insight.93683</ELocationID><ELocationID EIdType="pii" ValidYN="Y">93683</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with clinical immunity, but it is unknown whether these responses can be induced by human vaccination.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Safety and immunogenicity of replication-deficient chimpanzee adenovirus serotype 63 (ChAd63) and modified vaccinia virus Ankara (MVA) viral vectored vaccines targeting PvDBP_RII (Salvador I strain) were assessed in an open-label dose-escalation phase Ia study in 24 healthy UK adults. Vaccines were delivered by the intramuscular route in a ChAd63-MVA heterologous prime-boost regimen using an 8-week interval.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Both vaccines were well tolerated and demonstrated a favorable safety profile in malaria-naive adults. PvDBP_RII-specific ex-vivo IFN-γ T cell, antibody-secreting cell, memory B cell, and serum IgG responses were observed after the MVA boost immunization. Vaccine-induced antibodies inhibited the binding of vaccine homologous and heterologous variants of recombinant PvDBP_RII to the DARC receptor, with median 50% binding-inhibition titers greater than 1:100.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We have demonstrated for the first time to our knowledge that strain-transcending antibodies can be induced against the PvDBP_RII antigen by vaccination in humans. These vaccine candidates warrant further clinical evaluation of efficacy against the blood-stage P. vivax parasite.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">Clinicaltrials.gov NCT01816113.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Support was provided by the UK Medical Research Council, UK National Institute of Health Research Oxford Biomedical Research Centre, and the Wellcome Trust.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Payne</LastName><ForeName>Ruth O</ForeName><Initials>RO</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silk</LastName><ForeName>Sarah E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elias</LastName><ForeName>Sean C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milne</LastName><ForeName>Kathryn H</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rawlinson</LastName><ForeName>Thomas A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Llewellyn</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shakri</LastName><ForeName>A Rushdi</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Labbé</LastName><ForeName>Geneviève M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>Nick J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poulton</LastName><ForeName>Ian D</ForeName><Initials>ID</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farid</LastName><ForeName>Ryan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jørgensen</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>ExpreS2, ion Biotechnologies, SCION-DTU Science Park, Hørsholm, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alanine</LastName><ForeName>Daniel Gw</ForeName><Initials>DG</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Cassan</LastName><ForeName>Simone C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Higgins</LastName><ForeName>Matthew K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Otto</LastName><ForeName>Thomas D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>James S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Jongh</LastName><ForeName>Willem A</ForeName><Initials>WA</Initials><AffiliationInfo><Affiliation>ExpreS2, ion Biotechnologies, SCION-DTU Science Park, Hørsholm, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicosia</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>ReiThera SRL (formerly Okairòs SRL), Viale Città d'Europa, Rome, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CEINGE, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moyle</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Clinical Biomanufacturing Facility, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Adrian Vs</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berrie</LastName><ForeName>Eleanor</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Clinical Biomanufacturing Facility, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chitnis</LastName><ForeName>Chetan E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Pasteur, Department of Parasites and Insect Vectors, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawrie</LastName><ForeName>Alison M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Draper</LastName><ForeName>Simon J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>The Jenner Institute, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JCI 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IdType="pii">93683</ArticleId><ArticleId IdType="doi">10.1172/jci.insight.93683</ArticleId><ArticleId IdType="pmc">PMC5470884</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Danemark</li><li>Inde</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Latium</li><li>Oxfordshire</li></region><settlement><li>Oxford</li><li>Rome</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Payne, Ruth O" sort="Payne, Ruth O" uniqKey="Payne R" first="Ruth O" last="Payne">Ruth O. Payne</name></region><name sortKey="Alanine, Daniel Gw" sort="Alanine, Daniel Gw" uniqKey="Alanine D" first="Daniel Gw" last="Alanine">Daniel Gw Alanine</name><name sortKey="Berrie, Eleanor" sort="Berrie, Eleanor" uniqKey="Berrie E" first="Eleanor" last="Berrie">Eleanor Berrie</name><name sortKey="De Cassan, Simone C" sort="De Cassan, Simone C" uniqKey="De Cassan S" first="Simone C" last="De Cassan">Simone C. De Cassan</name><name sortKey="Draper, Simon J" sort="Draper, Simon J" uniqKey="Draper S" first="Simon J" last="Draper">Simon J. Draper</name><name sortKey="Edwards, Nick J" sort="Edwards, Nick J" uniqKey="Edwards N" first="Nick J" last="Edwards">Nick J. Edwards</name><name sortKey="Elias, Sean C" sort="Elias, Sean C" uniqKey="Elias S" first="Sean C" last="Elias">Sean C. Elias</name><name sortKey="Higgins, Matthew K" sort="Higgins, Matthew K" uniqKey="Higgins M" first="Matthew K" last="Higgins">Matthew K. Higgins</name><name sortKey="Hill, Adrian Vs" sort="Hill, Adrian Vs" uniqKey="Hill A" first="Adrian Vs" last="Hill">Adrian Vs Hill</name><name sortKey="Jin, Jing" sort="Jin, Jing" uniqKey="Jin J" first="Jing" last="Jin">Jing Jin</name><name sortKey="Labbe, Genevieve M" sort="Labbe, Genevieve M" uniqKey="Labbe G" first="Geneviève M" last="Labbé">Geneviève M. Labbé</name><name sortKey="Lawrie, Alison M" sort="Lawrie, Alison M" uniqKey="Lawrie A" first="Alison M" last="Lawrie">Alison M. Lawrie</name><name sortKey="Llewellyn, David" sort="Llewellyn, David" uniqKey="Llewellyn D" first="David" last="Llewellyn">David Llewellyn</name><name sortKey="Milne, Kathryn H" sort="Milne, Kathryn H" uniqKey="Milne K" first="Kathryn H" last="Milne">Kathryn H. Milne</name><name sortKey="Moyle, Sarah" sort="Moyle, Sarah" uniqKey="Moyle S" first="Sarah" last="Moyle">Sarah Moyle</name><name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. Otto</name><name sortKey="Poulton, Ian D" sort="Poulton, Ian D" uniqKey="Poulton I" first="Ian D" last="Poulton">Ian D. Poulton</name><name sortKey="Rawlinson, Thomas A" sort="Rawlinson, Thomas A" uniqKey="Rawlinson T" first="Thomas A" last="Rawlinson">Thomas A. Rawlinson</name><name sortKey="Roberts, Rachel" sort="Roberts, Rachel" uniqKey="Roberts R" first="Rachel" last="Roberts">Rachel Roberts</name><name sortKey="Silk, Sarah E" sort="Silk, Sarah E" uniqKey="Silk S" first="Sarah E" last="Silk">Sarah E. Silk</name></country><country name="Inde"><noRegion><name sortKey="Shakri, A Rushdi" sort="Shakri, A Rushdi" uniqKey="Shakri A" first="A Rushdi" last="Shakri">A Rushdi Shakri</name></noRegion><name sortKey="Chitnis, Chetan E" sort="Chitnis, Chetan E" uniqKey="Chitnis C" first="Chetan E" last="Chitnis">Chetan E. Chitnis</name></country><country name="Australie"><noRegion><name sortKey="Farid, Ryan" sort="Farid, Ryan" uniqKey="Farid R" first="Ryan" last="Farid">Ryan Farid</name></noRegion><name sortKey="Mccarthy, James S" sort="Mccarthy, James S" uniqKey="Mccarthy J" first="James S" last="Mccarthy">James S. Mccarthy</name></country><country name="Danemark"><noRegion><name sortKey="J Rgensen, Thomas" sort="J Rgensen, Thomas" uniqKey="J Rgensen T" first="Thomas" last="J Rgensen">Thomas J Rgensen</name></noRegion><name sortKey="De Jongh, Willem A" sort="De Jongh, Willem A" uniqKey="De Jongh W" first="Willem A" last="De Jongh">Willem A. De Jongh</name></country><country name="Italie"><region name="Latium"><name sortKey="Nicosia, Alfredo" sort="Nicosia, Alfredo" uniqKey="Nicosia A" first="Alfredo" last="Nicosia">Alfredo Nicosia</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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