Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle.
Identifieur interne : 000A31 ( PubMed/Checkpoint ); précédent : 000A30; suivant : 000A32Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle.
Auteurs : Mathieu Castela [France] ; Fabien Linay [France] ; Edwige Roy [France] ; Philippe Moguelet [France] ; Jie Xu [France] ; Martin Holzenberger [France] ; Kiarash Khosrotehrani [Australie] ; Selim Aractingi [France]Source :
- Experimental dermatology [ 1600-0625 ] ; 2017.
Abstract
Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15-Igf1r(KO) mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15-Igf1r(KO) mice than in controls, without consequences on wound healing, at least in young mice. K15-Igf1r(KO) HFs entered anagen phase earlier than controls and showed a delay in the anagen/catagen switch. The expression of Bmp-4 mRNA was inhibited in HFs from K15-Igf1r(KO) . MED1 transcription was impaired in the epidermis of K15-Igf1r(KO) mice. These findings suggest that Igf1r controls the hair cycle, partly through Bmp-4 activation.
DOI: 10.1111/exd.13287
PubMed: 28094870
Affiliations:
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Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Linay, Fabien" sort="Linay, Fabien" uniqKey="Linay F" first="Fabien" last="Linay">Fabien Linay</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRS_938, Saint-Antoine Research Center, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Roy, Edwige" sort="Roy, Edwige" uniqKey="Roy E" first="Edwige" last="Roy">Edwige Roy</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRS_938, Saint-Antoine Research Center, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moguelet, Philippe" sort="Moguelet, Philippe" uniqKey="Moguelet P" first="Philippe" last="Moguelet">Philippe Moguelet</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Hôpital Tenon AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Hôpital Tenon AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Xu, Jie" sort="Xu, Jie" uniqKey="Xu J" first="Jie" last="Xu">Jie Xu</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRS_938, Saint-Antoine Research Center, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Holzenberger, Martin" sort="Holzenberger, Martin" uniqKey="Holzenberger M" first="Martin" last="Holzenberger">Martin Holzenberger</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRS_938, Saint-Antoine Research Center, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Khosrotehrani, Kiarash" sort="Khosrotehrani, Kiarash" uniqKey="Khosrotehrani K" first="Kiarash" last="Khosrotehrani">Kiarash Khosrotehrani</name><affiliation wicri:level="1"><nlm:affiliation>Experimental Dermatology Group, UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Experimental Dermatology Group, UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Aractingi, Selim" sort="Aractingi, Selim" uniqKey="Aractingi S" first="Selim" last="Aractingi">Selim Aractingi</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRS_938, Saint-Antoine Research Center, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Experimental dermatology</title><idno type="eISSN">1600-0625</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15-Igf1r(KO) mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15-Igf1r(KO) mice than in controls, without consequences on wound healing, at least in young mice. K15-Igf1r(KO) HFs entered anagen phase earlier than controls and showed a delay in the anagen/catagen switch. The expression of Bmp-4 mRNA was inhibited in HFs from K15-Igf1r(KO) . MED1 transcription was impaired in the epidermis of K15-Igf1r(KO) mice. These findings suggest that Igf1r controls the hair cycle, partly through Bmp-4 activation.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28094870</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>17</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0625</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>9</Issue><PubDate><Year>2017</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Experimental dermatology</Title><ISOAbbreviation>Exp. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle.</ArticleTitle><Pagination><MedlinePgn>785-791</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/exd.13287</ELocationID><Abstract><AbstractText>Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15-Igf1r(KO) mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15-Igf1r(KO) mice than in controls, without consequences on wound healing, at least in young mice. K15-Igf1r(KO) HFs entered anagen phase earlier than controls and showed a delay in the anagen/catagen switch. The expression of Bmp-4 mRNA was inhibited in HFs from K15-Igf1r(KO) . MED1 transcription was impaired in the epidermis of K15-Igf1r(KO) mice. These findings suggest that Igf1r controls the hair cycle, partly through Bmp-4 activation.</AbstractText><CopyrightInformation>© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Castela</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-8745-9583</Identifier><AffiliationInfo><Affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UPMC Université Paris 6, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Linay</LastName><ForeName>Fabien</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UPMC Université Paris 6, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roy</LastName><ForeName>Edwige</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UPMC Université Paris 6, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Experimental Dermatology Group, UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moguelet</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Pathology, Hôpital Tenon AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UPMC Université Paris 6, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holzenberger</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UPMC Université Paris 6, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khosrotehrani</LastName><ForeName>Kiarash</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Experimental Dermatology Group, UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aractingi</LastName><ForeName>Selim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>INSERM UMRS_938, Saint-Antoine Research Center, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris 5 Descartes, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Dermatology, Hôpital Cochin, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Exp Dermatol</MedlineTA><NlmUniqueID>9301549</NlmUniqueID><ISSNLinking>0906-6705</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Igf1r</Keyword><Keyword MajorTopicYN="N">anagen</Keyword><Keyword MajorTopicYN="N">conditional gene targeting</Keyword><Keyword MajorTopicYN="N">hair cycle</Keyword><Keyword MajorTopicYN="N">stem cells</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28094870</ArticleId><ArticleId IdType="doi">10.1111/exd.13287</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Castela, Mathieu" sort="Castela, Mathieu" uniqKey="Castela M" first="Mathieu" last="Castela">Mathieu Castela</name></region><name sortKey="Aractingi, Selim" sort="Aractingi, Selim" uniqKey="Aractingi S" first="Selim" last="Aractingi">Selim Aractingi</name><name sortKey="Holzenberger, Martin" sort="Holzenberger, Martin" uniqKey="Holzenberger M" first="Martin" last="Holzenberger">Martin Holzenberger</name><name sortKey="Linay, Fabien" sort="Linay, Fabien" uniqKey="Linay F" first="Fabien" last="Linay">Fabien Linay</name><name sortKey="Moguelet, Philippe" sort="Moguelet, Philippe" uniqKey="Moguelet P" first="Philippe" last="Moguelet">Philippe Moguelet</name><name sortKey="Roy, Edwige" sort="Roy, Edwige" uniqKey="Roy E" first="Edwige" last="Roy">Edwige Roy</name><name sortKey="Xu, Jie" sort="Xu, Jie" uniqKey="Xu J" first="Jie" last="Xu">Jie Xu</name></country><country name="Australie"><noRegion><name sortKey="Khosrotehrani, Kiarash" sort="Khosrotehrani, Kiarash" uniqKey="Khosrotehrani K" first="Kiarash" last="Khosrotehrani">Kiarash Khosrotehrani</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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