AustralieFrV1, PubMed, Checkpoint, bibRecord, 000897

Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.

Identifieur interne : 000897 ( PubMed/Checkpoint ); précédent : 000896; suivant : 000898

Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.

Auteurs : Liliana M. Massis ; Mariana A. Assis-Marques ; Fernanda V S. Castanheira ; Yasmin J. Capobianco ; Andiamira C. Balestra [Brésil] ; Pedro Escoll ; Rebecca E. Wood [Australie] ; Graziele Z. Manin ; Vani M A. Correa ; José C. Alves-Filho ; Fernando Q. Cunha ; Carmen Buchrieser ; Marcos C. Borges [Brésil] ; Hayley J. Newton [Australie] ; Dario S. Zamboni

Source :

The Journal of infectious diseases [ 1537-6613 ] ; 2017.

RBID : pubmed:27932612

Descripteurs français

KwdFr :
- Agranulocytes, Animaux, Cytokines (métabolisme), Femelle, Humains, Legionella longbeachae (immunologie), Legionella longbeachae (pathogénicité), Legionella pneumophila (immunologie), Légionellose (anatomopathologie), Légionellose (immunologie), Légionellose (microbiologie), Légionellose (physiopathologie), Macrophages (immunologie), Poumon (physiopathologie), Résistance à la maladie (immunologie), Souris, Souris de lignée C57BL, Spécificité d'espèce, Virulence.
MESH :
- anatomopathologie : Légionellose.
- immunologie : Legionella longbeachae, Legionella pneumophila, Légionellose, Macrophages, Résistance à la maladie.
- microbiologie : Légionellose.
- métabolisme : Cytokines.
- pathogénicité : Legionella longbeachae.
- physiopathologie : Légionellose, Poumon.
- Agranulocytes, Animaux, Femelle, Humains, Souris, Souris de lignée C57BL, Spécificité d'espèce, Virulence.

English descriptors

KwdEn :
- Animals, Cytokines (metabolism), Disease Resistance (immunology), Female, Humans, Legionella longbeachae (immunology), Legionella longbeachae (pathogenicity), Legionella pneumophila (immunology), Legionellosis (immunology), Legionellosis (microbiology), Legionellosis (pathology), Legionellosis (physiopathology), Leukocytes, Mononuclear, Lung (physiopathology), Macrophages (immunology), Mice, Mice, Inbred C57BL, Species Specificity, Virulence.
MESH :
- chemical , metabolism : Cytokines.
- immunology : Disease Resistance, Legionella longbeachae, Legionella pneumophila, Legionellosis, Macrophages.
- microbiology : Legionellosis.
- pathogenicity : Legionella longbeachae.
- pathology : Legionellosis.
- physiopathology : Legionellosis, Lung.
- Animals, Female, Humans, Leukocytes, Mononuclear, Mice, Mice, Inbred C57BL, Species Specificity, Virulence.

Abstract

Legionella longbeachae (Llo) and Legionella pneumophila (Lpn) are the most common pneumonia-causing agents of the genus. Although both species can be lethal to humans and are highly prevalent, little is known about the molecular pathogenesis of Llo infections. In murine models of infection, Lpn infection is self-limited, whereas Llo infection is lethal.

DOI: 10.1093/infdis/jiw560
PubMed: 27932612

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001103
to stream PubMed, to step Curation: 001100

Links to Exploration step

pubmed:27932612

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.</title>
<author><name sortKey="Massis, Liliana M" sort="Massis, Liliana M" uniqKey="Massis L" first="Liliana M" last="Massis">Liliana M. Massis</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Assis Marques, Mariana A" sort="Assis Marques, Mariana A" uniqKey="Assis Marques M" first="Mariana A" last="Assis-Marques">Mariana A. Assis-Marques</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Castanheira, Fernanda V S" sort="Castanheira, Fernanda V S" uniqKey="Castanheira F" first="Fernanda V S" last="Castanheira">Fernanda V S. Castanheira</name>
<affiliation><nlm:affiliation>Department of Pharmacology, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Capobianco, Yasmin J" sort="Capobianco, Yasmin J" uniqKey="Capobianco Y" first="Yasmin J" last="Capobianco">Yasmin J. Capobianco</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Balestra, Andiamira C" sort="Balestra, Andiamira C" uniqKey="Balestra A" first="Andiamira C" last="Balestra">Andiamira C. Balestra</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto,Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto</wicri:regionArea>
<orgName type="university">Université de São Paulo</orgName>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escoll, Pedro" sort="Escoll, Pedro" uniqKey="Escoll P" first="Pedro" last="Escoll">Pedro Escoll</name>
<affiliation><nlm:affiliation>Biology of Intracellular Bacteria, Institut Pasteur, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wood, Rebecca E" sort="Wood, Rebecca E" uniqKey="Wood R" first="Rebecca E" last="Wood">Rebecca E. Wood</name>
<affiliation wicri:level="4"><nlm:affiliation>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Manin, Graziele Z" sort="Manin, Graziele Z" uniqKey="Manin G" first="Graziele Z" last="Manin">Graziele Z. Manin</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Correa, Vani M A" sort="Correa, Vani M A" uniqKey="Correa V" first="Vani M A" last="Correa">Vani M A. Correa</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alves Filho, Jose C" sort="Alves Filho, Jose C" uniqKey="Alves Filho J" first="José C" last="Alves-Filho">José C. Alves-Filho</name>
<affiliation><nlm:affiliation>Department of Pharmacology, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cunha, Fernando Q" sort="Cunha, Fernando Q" uniqKey="Cunha F" first="Fernando Q" last="Cunha">Fernando Q. Cunha</name>
<affiliation><nlm:affiliation>Department of Pharmacology, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<affiliation><nlm:affiliation>Biology of Intracellular Bacteria, Institut Pasteur, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Borges, Marcos C" sort="Borges, Marcos C" uniqKey="Borges M" first="Marcos C" last="Borges">Marcos C. Borges</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto,Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto</wicri:regionArea>
<orgName type="university">Université de São Paulo</orgName>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newton, Hayley J" sort="Newton, Hayley J" uniqKey="Newton H" first="Hayley J" last="Newton">Hayley J. Newton</name>
<affiliation wicri:level="4"><nlm:affiliation>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zamboni, Dario S" sort="Zamboni, Dario S" uniqKey="Zamboni D" first="Dario S" last="Zamboni">Dario S. Zamboni</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:27932612</idno>
<idno type="pmid">27932612</idno>
<idno type="doi">10.1093/infdis/jiw560</idno>
<idno type="wicri:Area/PubMed/Corpus">001103</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001103</idno>
<idno type="wicri:Area/PubMed/Curation">001100</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001100</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001100</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001100</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.</title>
<author><name sortKey="Massis, Liliana M" sort="Massis, Liliana M" uniqKey="Massis L" first="Liliana M" last="Massis">Liliana M. Massis</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Assis Marques, Mariana A" sort="Assis Marques, Mariana A" uniqKey="Assis Marques M" first="Mariana A" last="Assis-Marques">Mariana A. Assis-Marques</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Castanheira, Fernanda V S" sort="Castanheira, Fernanda V S" uniqKey="Castanheira F" first="Fernanda V S" last="Castanheira">Fernanda V S. Castanheira</name>
<affiliation><nlm:affiliation>Department of Pharmacology, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Capobianco, Yasmin J" sort="Capobianco, Yasmin J" uniqKey="Capobianco Y" first="Yasmin J" last="Capobianco">Yasmin J. Capobianco</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Balestra, Andiamira C" sort="Balestra, Andiamira C" uniqKey="Balestra A" first="Andiamira C" last="Balestra">Andiamira C. Balestra</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto,Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto</wicri:regionArea>
<orgName type="university">Université de São Paulo</orgName>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escoll, Pedro" sort="Escoll, Pedro" uniqKey="Escoll P" first="Pedro" last="Escoll">Pedro Escoll</name>
<affiliation><nlm:affiliation>Biology of Intracellular Bacteria, Institut Pasteur, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wood, Rebecca E" sort="Wood, Rebecca E" uniqKey="Wood R" first="Rebecca E" last="Wood">Rebecca E. Wood</name>
<affiliation wicri:level="4"><nlm:affiliation>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Manin, Graziele Z" sort="Manin, Graziele Z" uniqKey="Manin G" first="Graziele Z" last="Manin">Graziele Z. Manin</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Correa, Vani M A" sort="Correa, Vani M A" uniqKey="Correa V" first="Vani M A" last="Correa">Vani M A. Correa</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alves Filho, Jose C" sort="Alves Filho, Jose C" uniqKey="Alves Filho J" first="José C" last="Alves-Filho">José C. Alves-Filho</name>
<affiliation><nlm:affiliation>Department of Pharmacology, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cunha, Fernando Q" sort="Cunha, Fernando Q" uniqKey="Cunha F" first="Fernando Q" last="Cunha">Fernando Q. Cunha</name>
<affiliation><nlm:affiliation>Department of Pharmacology, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<affiliation><nlm:affiliation>Biology of Intracellular Bacteria, Institut Pasteur, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Borges, Marcos C" sort="Borges, Marcos C" uniqKey="Borges M" first="Marcos C" last="Borges">Marcos C. Borges</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto,Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto</wicri:regionArea>
<orgName type="university">Université de São Paulo</orgName>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newton, Hayley J" sort="Newton, Hayley J" uniqKey="Newton H" first="Hayley J" last="Newton">Hayley J. Newton</name>
<affiliation wicri:level="4"><nlm:affiliation>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zamboni, Dario S" sort="Zamboni, Dario S" uniqKey="Zamboni D" first="Dario S" last="Zamboni">Dario S. Zamboni</name>
<affiliation><nlm:affiliation>Department of Cell Biology.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Cell Biology.</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of infectious diseases</title>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cytokines (metabolism)</term>
<term>Disease Resistance (immunology)</term>
<term>Female</term>
<term>Humans</term>
<term>Legionella longbeachae (immunology)</term>
<term>Legionella longbeachae (pathogenicity)</term>
<term>Legionella pneumophila (immunology)</term>
<term>Legionellosis (immunology)</term>
<term>Legionellosis (microbiology)</term>
<term>Legionellosis (pathology)</term>
<term>Legionellosis (physiopathology)</term>
<term>Leukocytes, Mononuclear</term>
<term>Lung (physiopathology)</term>
<term>Macrophages (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Species Specificity</term>
<term>Virulence</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agranulocytes</term>
<term>Animaux</term>
<term>Cytokines (métabolisme)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Legionella longbeachae (immunologie)</term>
<term>Legionella longbeachae (pathogénicité)</term>
<term>Legionella pneumophila (immunologie)</term>
<term>Légionellose (anatomopathologie)</term>
<term>Légionellose (immunologie)</term>
<term>Légionellose (microbiologie)</term>
<term>Légionellose (physiopathologie)</term>
<term>Macrophages (immunologie)</term>
<term>Poumon (physiopathologie)</term>
<term>Résistance à la maladie (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Spécificité d'espèce</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Légionellose</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Legionella longbeachae</term>
<term>Legionella pneumophila</term>
<term>Légionellose</term>
<term>Macrophages</term>
<term>Résistance à la maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Disease Resistance</term>
<term>Legionella longbeachae</term>
<term>Legionella pneumophila</term>
<term>Legionellosis</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Légionellose</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Legionellosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Legionella longbeachae</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Legionella longbeachae</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Legionellosis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Légionellose</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Legionellosis</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Humans</term>
<term>Leukocytes, Mononuclear</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Species Specificity</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Agranulocytes</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Spécificité d'espèce</term>
<term>Virulence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Legionella longbeachae (Llo) and Legionella pneumophila (Lpn) are the most common pneumonia-causing agents of the genus. Although both species can be lethal to humans and are highly prevalent, little is known about the molecular pathogenesis of Llo infections. In murine models of infection, Lpn infection is self-limited, whereas Llo infection is lethal.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27932612</PMID>
<DateCreated><Year>2016</Year>
<Month>12</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>06</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>06</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>215</Volume>
<Issue>3</Issue>
<PubDate><Year>2017</Year>
<Month>Feb</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.</ArticleTitle>
<Pagination><MedlinePgn>440-451</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiw560</ELocationID>
<Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Legionella longbeachae (Llo) and Legionella pneumophila (Lpn) are the most common pneumonia-causing agents of the genus. Although both species can be lethal to humans and are highly prevalent, little is known about the molecular pathogenesis of Llo infections. In murine models of infection, Lpn infection is self-limited, whereas Llo infection is lethal.</AbstractText>
<AbstractText Label="Methods" NlmCategory="UNASSIGNED">We used mouse macrophages, human macrophages, human epithelial cells, and mouse infections in vivo to evaluate multiple parameters of the infection.</AbstractText>
<AbstractText Label="Results" NlmCategory="UNASSIGNED">We determined that the Llo Dot/Icm secretion system is critical for virulence. Different than Lpn, Llo disseminates and the animals develop a severe pulmonary failure, as demonstrated by lung mechanics and blood oxygenation assays. As compared to Lpn, Llo is immunologically silent and fails to trigger the production of cytokines in human pulmonary epithelial cells and in mouse and human macrophages. Infections in Tnfr1-/-, Ifng-/-, and Il12p40-/- mice supported the participation of cytokines for the resistance phenotype.</AbstractText>
<AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Both Lpn and Llo require the Dot/Icm system for pathogenesis, but the infection outcome is strikingly different. Llo is immunologically silent, highly virulent, and lethal. The differences reported herein may reflect unappreciated clinical differences in patients infected with Lpn or Llo.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Massis</LastName>
<ForeName>Liliana M</ForeName>
<Initials>LM</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Assis-Marques</LastName>
<ForeName>Mariana A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Castanheira</LastName>
<ForeName>Fernanda V S</ForeName>
<Initials>FV</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Capobianco</LastName>
<ForeName>Yasmin J</ForeName>
<Initials>YJ</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Balestra</LastName>
<ForeName>Andiamira C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto,Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Escoll</LastName>
<ForeName>Pedro</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Biology of Intracellular Bacteria, Institut Pasteur, and.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CNRS UMR 3525, Paris, France ; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wood</LastName>
<ForeName>Rebecca E</ForeName>
<Initials>RE</Initials>
<AffiliationInfo><Affiliation>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Manin</LastName>
<ForeName>Graziele Z</ForeName>
<Initials>GZ</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Correa</LastName>
<ForeName>Vani M A</ForeName>
<Initials>VM</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alves-Filho</LastName>
<ForeName>José C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cunha</LastName>
<ForeName>Fernando Q</ForeName>
<Initials>FQ</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Buchrieser</LastName>
<ForeName>Carmen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Biology of Intracellular Bacteria, Institut Pasteur, and.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CNRS UMR 3525, Paris, France; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borges</LastName>
<ForeName>Marcos C</ForeName>
<Initials>MC</Initials>
<AffiliationInfo><Affiliation>Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, FMRP/USP, Ribeirão Preto,Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Newton</LastName>
<ForeName>Hayley J</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zamboni</LastName>
<ForeName>Dario S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Infect Dis</MedlineTA>
<NlmUniqueID>0413675</NlmUniqueID>
<ISSNLinking>0022-1899</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060467" MajorTopicYN="N">Disease Resistance</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044128" MajorTopicYN="N">Legionella longbeachae</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016952" MajorTopicYN="N">Legionella pneumophila</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007876" MajorTopicYN="N">Legionellosis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007963" MajorTopicYN="N">Leukocytes, Mononuclear</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Legionella longbeachae</Keyword>
<Keyword MajorTopicYN="Y">Type IV secretion system</Keyword>
<Keyword MajorTopicYN="Y">macrophages.</Keyword>
<Keyword MajorTopicYN="Y">pulmonary infection</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>07</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>11</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>12</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>6</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>12</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27932612</ArticleId>
<ArticleId IdType="pii">jiw560</ArticleId>
<ArticleId IdType="doi">10.1093/infdis/jiw560</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>Brésil</li>
</country>
<region><li>Victoria (État)</li>
<li>État de São Paulo</li>
</region>
<settlement><li>Melbourne</li>
<li>São Paulo</li>
</settlement>
<orgName><li>Université de Melbourne</li>
<li>Université de São Paulo</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Alves Filho, Jose C" sort="Alves Filho, Jose C" uniqKey="Alves Filho J" first="José C" last="Alves-Filho">José C. Alves-Filho</name>
<name sortKey="Assis Marques, Mariana A" sort="Assis Marques, Mariana A" uniqKey="Assis Marques M" first="Mariana A" last="Assis-Marques">Mariana A. Assis-Marques</name>
<name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<name sortKey="Capobianco, Yasmin J" sort="Capobianco, Yasmin J" uniqKey="Capobianco Y" first="Yasmin J" last="Capobianco">Yasmin J. Capobianco</name>
<name sortKey="Castanheira, Fernanda V S" sort="Castanheira, Fernanda V S" uniqKey="Castanheira F" first="Fernanda V S" last="Castanheira">Fernanda V S. Castanheira</name>
<name sortKey="Correa, Vani M A" sort="Correa, Vani M A" uniqKey="Correa V" first="Vani M A" last="Correa">Vani M A. Correa</name>
<name sortKey="Cunha, Fernando Q" sort="Cunha, Fernando Q" uniqKey="Cunha F" first="Fernando Q" last="Cunha">Fernando Q. Cunha</name>
<name sortKey="Escoll, Pedro" sort="Escoll, Pedro" uniqKey="Escoll P" first="Pedro" last="Escoll">Pedro Escoll</name>
<name sortKey="Manin, Graziele Z" sort="Manin, Graziele Z" uniqKey="Manin G" first="Graziele Z" last="Manin">Graziele Z. Manin</name>
<name sortKey="Massis, Liliana M" sort="Massis, Liliana M" uniqKey="Massis L" first="Liliana M" last="Massis">Liliana M. Massis</name>
<name sortKey="Zamboni, Dario S" sort="Zamboni, Dario S" uniqKey="Zamboni D" first="Dario S" last="Zamboni">Dario S. Zamboni</name>
</noCountry>
<country name="Brésil"><region name="État de São Paulo"><name sortKey="Balestra, Andiamira C" sort="Balestra, Andiamira C" uniqKey="Balestra A" first="Andiamira C" last="Balestra">Andiamira C. Balestra</name>
</region>
<name sortKey="Borges, Marcos C" sort="Borges, Marcos C" uniqKey="Borges M" first="Marcos C" last="Borges">Marcos C. Borges</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Wood, Rebecca E" sort="Wood, Rebecca E" uniqKey="Wood R" first="Rebecca E" last="Wood">Rebecca E. Wood</name>
</region>
<name sortKey="Newton, Hayley J" sort="Newton, Hayley J" uniqKey="Newton H" first="Hayley J" last="Newton">Hayley J. Newton</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000897 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000897 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:27932612
   |texte=   Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:27932612" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.

Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki