Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials.
Identifieur interne : 000871 ( PubMed/Checkpoint ); précédent : 000870; suivant : 000872Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials.
Auteurs : Stanley B. Cohen [États-Unis] ; Yoshiya Tanaka [Japon] ; Xavier Mariette [France] ; Jeffrey R. Curtis [États-Unis] ; Eun Bong Lee [Corée du Sud] ; Peter Nash [Australie] ; Kevin L. Winthrop [États-Unis] ; Christina Charles-Schoeman [États-Unis] ; Krishan Thirunavukkarasu [Australie] ; Ryan Demasi [États-Unis] ; Jamie Geier [États-Unis] ; Kenneth Kwok [États-Unis] ; Lisy Wang [États-Unis] ; Richard Riese [États-Unis] ; Jürgen Wollenhaupt [Allemagne]Source :
- Annals of the rheumatic diseases [ 1468-2060 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Essais cliniques comme sujet, Facteurs temps, Femelle, Humains, Incidence, Infection (immunologie), Infection (épidémiologie), Infection (étiologie), Infections opportunistes (immunologie), Infections opportunistes (épidémiologie), Infections opportunistes (étiologie), Inhibiteurs de protéines kinases (effets indésirables), Jeune adulte, Mâle, Pipéridines (effets indésirables), Polyarthrite rhumatoïde (traitement médicamenteux), Pyrimidines (effets indésirables), Pyrroles (effets indésirables), Sujet immunodéprimé, Sujet âgé, Sujet âgé de 80 ans ou plus, Tuberculose (immunologie), Tuberculose (épidémiologie), Tuberculose (étiologie), Tumeurs (immunologie), Tumeurs (épidémiologie), Tumeurs (étiologie), Zona (immunologie), Zona (épidémiologie), Zona (étiologie).
- MESH :
- effets indésirables : Inhibiteurs de protéines kinases, Pipéridines, Pyrimidines, Pyrroles.
- immunologie : Infection, Infections opportunistes, Tuberculose, Tumeurs, Zona.
- traitement médicamenteux : Polyarthrite rhumatoïde.
- épidémiologie : Infection, Infections opportunistes, Tuberculose, Tumeurs, Zona.
- étiologie : Infection, Infections opportunistes, Tuberculose, Tumeurs, Zona.
- Adolescent, Adulte, Adulte d'âge moyen, Essais cliniques comme sujet, Facteurs temps, Femelle, Humains, Incidence, Jeune adulte, Mâle, Sujet immunodéprimé, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Arthritis, Rheumatoid (drug therapy), Clinical Trials as Topic, Female, Herpes Zoster (epidemiology), Herpes Zoster (etiology), Herpes Zoster (immunology), Humans, Immunocompromised Host, Incidence, Infection (epidemiology), Infection (etiology), Infection (immunology), Male, Middle Aged, Neoplasms (epidemiology), Neoplasms (etiology), Neoplasms (immunology), Opportunistic Infections (epidemiology), Opportunistic Infections (etiology), Opportunistic Infections (immunology), Piperidines (adverse effects), Protein Kinase Inhibitors (adverse effects), Pyrimidines (adverse effects), Pyrroles (adverse effects), Time Factors, Tuberculosis (epidemiology), Tuberculosis (etiology), Tuberculosis (immunology), Young Adult.
- MESH :
- chemical , adverse effects : Piperidines, Protein Kinase Inhibitors, Pyrimidines, Pyrroles.
- drug therapy : Arthritis, Rheumatoid.
- epidemiology : Herpes Zoster, Infection, Neoplasms, Opportunistic Infections, Tuberculosis.
- etiology : Herpes Zoster, Infection, Neoplasms, Opportunistic Infections, Tuberculosis.
- immunology : Herpes Zoster, Infection, Neoplasms, Opportunistic Infections, Tuberculosis.
- Adolescent, Adult, Aged, Aged, 80 and over, Clinical Trials as Topic, Female, Humans, Immunocompromised Host, Incidence, Male, Middle Aged, Time Factors, Young Adult.
Abstract
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report an integrated safety summary of tofacitinib from two phase I, nine phase II, six phase III and two long-term extension studies in adult patients with active RA.
DOI: 10.1136/annrheumdis-2016-210457
PubMed: 28143815
Affiliations:
- Allemagne, Australie, Corée du Sud, France, Japon, États-Unis
- Alabama, Californie, Connecticut, Hambourg, Nouvelle-Galles du Sud, Oregon, Région capitale de Séoul, Texas, État de New York
- Hambourg, Sydney, Séoul
- Université nationale de Séoul
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pubmed:28143815Le document en format XML
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<author><name sortKey="Thirunavukkarasu, Krishan" sort="Thirunavukkarasu, Krishan" uniqKey="Thirunavukkarasu K" first="Krishan" last="Thirunavukkarasu">Krishan Thirunavukkarasu</name>
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<author><name sortKey="Demasi, Ryan" sort="Demasi, Ryan" uniqKey="Demasi R" first="Ryan" last="Demasi">Ryan Demasi</name>
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<author><name sortKey="Geier, Jamie" sort="Geier, Jamie" uniqKey="Geier J" first="Jamie" last="Geier">Jamie Geier</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Kwok, Kenneth" sort="Kwok, Kenneth" uniqKey="Kwok K" first="Kenneth" last="Kwok">Kenneth Kwok</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Wang, Lisy" sort="Wang, Lisy" uniqKey="Wang L" first="Lisy" last="Wang">Lisy Wang</name>
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<author><name sortKey="Riese, Richard" sort="Riese, Richard" uniqKey="Riese R" first="Richard" last="Riese">Richard Riese</name>
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<author><name sortKey="Wollenhaupt, Jurgen" sort="Wollenhaupt, Jurgen" uniqKey="Wollenhaupt J" first="Jürgen" last="Wollenhaupt">Jürgen Wollenhaupt</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Arthritis, Rheumatoid (drug therapy)</term>
<term>Clinical Trials as Topic</term>
<term>Female</term>
<term>Herpes Zoster (epidemiology)</term>
<term>Herpes Zoster (etiology)</term>
<term>Herpes Zoster (immunology)</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Incidence</term>
<term>Infection (epidemiology)</term>
<term>Infection (etiology)</term>
<term>Infection (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasms (epidemiology)</term>
<term>Neoplasms (etiology)</term>
<term>Neoplasms (immunology)</term>
<term>Opportunistic Infections (epidemiology)</term>
<term>Opportunistic Infections (etiology)</term>
<term>Opportunistic Infections (immunology)</term>
<term>Piperidines (adverse effects)</term>
<term>Protein Kinase Inhibitors (adverse effects)</term>
<term>Pyrimidines (adverse effects)</term>
<term>Pyrroles (adverse effects)</term>
<term>Time Factors</term>
<term>Tuberculosis (epidemiology)</term>
<term>Tuberculosis (etiology)</term>
<term>Tuberculosis (immunology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Essais cliniques comme sujet</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Infection (immunologie)</term>
<term>Infection (épidémiologie)</term>
<term>Infection (étiologie)</term>
<term>Infections opportunistes (immunologie)</term>
<term>Infections opportunistes (épidémiologie)</term>
<term>Infections opportunistes (étiologie)</term>
<term>Inhibiteurs de protéines kinases (effets indésirables)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Pipéridines (effets indésirables)</term>
<term>Polyarthrite rhumatoïde (traitement médicamenteux)</term>
<term>Pyrimidines (effets indésirables)</term>
<term>Pyrroles (effets indésirables)</term>
<term>Sujet immunodéprimé</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tuberculose (immunologie)</term>
<term>Tuberculose (épidémiologie)</term>
<term>Tuberculose (étiologie)</term>
<term>Tumeurs (immunologie)</term>
<term>Tumeurs (épidémiologie)</term>
<term>Tumeurs (étiologie)</term>
<term>Zona (immunologie)</term>
<term>Zona (épidémiologie)</term>
<term>Zona (étiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Piperidines</term>
<term>Protein Kinase Inhibitors</term>
<term>Pyrimidines</term>
<term>Pyrroles</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Inhibiteurs de protéines kinases</term>
<term>Pipéridines</term>
<term>Pyrimidines</term>
<term>Pyrroles</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Herpes Zoster</term>
<term>Infection</term>
<term>Neoplasms</term>
<term>Opportunistic Infections</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Herpes Zoster</term>
<term>Infection</term>
<term>Neoplasms</term>
<term>Opportunistic Infections</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infection</term>
<term>Infections opportunistes</term>
<term>Tuberculose</term>
<term>Tumeurs</term>
<term>Zona</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Herpes Zoster</term>
<term>Infection</term>
<term>Neoplasms</term>
<term>Opportunistic Infections</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infection</term>
<term>Infections opportunistes</term>
<term>Tuberculose</term>
<term>Tumeurs</term>
<term>Zona</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infection</term>
<term>Infections opportunistes</term>
<term>Tuberculose</term>
<term>Tumeurs</term>
<term>Zona</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Clinical Trials as Topic</term>
<term>Female</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Essais cliniques comme sujet</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sujet immunodéprimé</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<front><div type="abstract" xml:lang="en">Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report an integrated safety summary of tofacitinib from two phase I, nine phase II, six phase III and two long-term extension studies in adult patients with active RA.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28143815</PMID>
<DateCreated><Year>2017</Year>
<Month>02</Month>
<Day>01</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>08</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-2060</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>76</Volume>
<Issue>7</Issue>
<PubDate><Year>2017</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Annals of the rheumatic diseases</Title>
<ISOAbbreviation>Ann. Rheum. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials.</ArticleTitle>
<Pagination><MedlinePgn>1253-1262</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/annrheumdis-2016-210457</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report an integrated safety summary of tofacitinib from two phase I, nine phase II, six phase III and two long-term extension studies in adult patients with active RA.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Data were pooled for all tofacitinib-treated patients (data cut-off: 31 March 2015). Incidence rates (IRs; patients with event/100 patient-years) and 95% CIs are reported for adverse events (AEs) of interest.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">6194 patients received tofacitinib for a total 19 406 patient-years' exposure; median exposure was 3.4 patient-years. IR (95% CI) for serious AEs was 9.4 (9.0 to 9.9); IR for serious infections was 2.7 (2.5 to 3.0). IR for (all) herpes zoster was 3.9 (3.6 to 4.2); IR for disseminated or multidermatomal herpes zoster was 0.3 (0.2 to 0.4). IR for opportunistic infections (excluding tuberculosis) was 0.3 (0.2 to 0.4) and was 0.2 (0.1 to 0.3) for tuberculosis. IR for malignancies (excluding non-melanoma skin cancer (NMSC)) was 0.9 (0.8 to 1.0); NMSC IR was 0.6 (0.5 to 0.7). IR for gastrointestinal perforations was 0.1 (0.1 to 0.2). Analysis of IR for serious infections, herpes zoster and malignancies by 6-month intervals did not reveal any notable increase in IR with longer-duration tofacitinib exposure.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This analysis of tofacitinib exposure up to 8.5 years allowed estimation of safety events with improved precision versus previous tofacitinib reports. AEs were generally stable over time; no new safety signals were observed compared with previous tofacitinib reports.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION NUMBERS" NlmCategory="UNASSIGNED">NCT01262118, NCT01484561, NCT00147498, NCT00413660, NCT00550446, NCT00603512, NCT00687193, NCT01164579, NCT00976599, NCT01059864, NCT01359150, NCT00960440, NCT00847613, NCT00814307, NCT00856544, NCT00853385, NCT01039688, NCT00413699, NCT00661661; Results.</AbstractText>
<CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cohen</LastName>
<ForeName>Stanley B</ForeName>
<Initials>SB</Initials>
<AffiliationInfo><Affiliation>Metroplex Clinical Research Center, Dallas, Texas, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tanaka</LastName>
<ForeName>Yoshiya</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>University of Occupational and Environmental Health, Kitakyushu, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mariette</LastName>
<ForeName>Xavier</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Paris-Sud University, Le Kremlin Bicêtre, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Curtis</LastName>
<ForeName>Jeffrey R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>University of Alabama at Birmingham, Birmingham, Alabama, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Eun Bong</ForeName>
<Initials>EB</Initials>
<AffiliationInfo><Affiliation>Seoul National University, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nash</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>University of Queensland, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Winthrop</LastName>
<ForeName>Kevin L</ForeName>
<Initials>KL</Initials>
<AffiliationInfo><Affiliation>Oregon Health and Science University, Portland, Oregon, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Charles-Schoeman</LastName>
<ForeName>Christina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University of California, Los Angeles, California, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thirunavukkarasu</LastName>
<ForeName>Krishan</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Pfizer Australia, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>DeMasi</LastName>
<ForeName>Ryan</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Pfizer Inc, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Geier</LastName>
<ForeName>Jamie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Pfizer Inc, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kwok</LastName>
<ForeName>Kenneth</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Pfizer Inc, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Lisy</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Pfizer Inc, Groton, Connecticut, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Riese</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Pfizer Inc, Groton, Connecticut, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wollenhaupt</LastName>
<ForeName>Jürgen</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>University of Hamburg, Hamburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>01</Month>
<Day>31</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Ann Rheum Dis</MedlineTA>
<NlmUniqueID>0372355</NlmUniqueID>
<ISSNLinking>0003-4967</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010880">Piperidines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D047428">Protein Kinase Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011743">Pyrimidines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011758">Pyrroles</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>87LA6FU830</RegistryNumber>
<NameOfSubstance UI="C479163">tofacitinib</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001172" MajorTopicYN="N">Arthritis, Rheumatoid</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002986" MajorTopicYN="N">Clinical Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006562" MajorTopicYN="N">Herpes Zoster</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016867" MajorTopicYN="Y">Immunocompromised Host</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007239" MajorTopicYN="N">Infection</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009894" MajorTopicYN="N">Opportunistic Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010880" MajorTopicYN="N">Piperidines</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D047428" MajorTopicYN="N">Protein Kinase Inhibitors</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011743" MajorTopicYN="N">Pyrimidines</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011758" MajorTopicYN="N">Pyrroles</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014376" MajorTopicYN="N">Tuberculosis</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cardiovascular Disease</Keyword>
<Keyword MajorTopicYN="N">Infections</Keyword>
<Keyword MajorTopicYN="N">Rheumatoid Arthritis</Keyword>
<Keyword MajorTopicYN="N">Treatment</Keyword>
<Keyword MajorTopicYN="N">Tuberculosis</Keyword>
</KeywordList>
<CoiStatement>Competing interests: SBC, KLW, CC-S and JW have served as consultants for, and have received speaker fees and honoraria from, Pfizer Inc. YT has served as a consultant for, and has received speaker fees and honoraria from, AbbVie, Asahi-kasei, Astellas Pharma, BMS, Chugai Pharma, Daiichi Sankyo, Eli Lilly, GlaxoSmithKline, Janssen, Mitsubishi-Tanabe, Pfizer Inc, Sanofi, Takeda, Teijin and YL Biologics. XM has served as a consultant for, and has received speaker fees and honoraria from, BMS, GlaxoSmithKline, Pfizer Inc and UCB. EBL has served as a consultant for Pfizer Inc. KT, RDM, JG, KK and LW are employees and shareholders of Pfizer Inc. RR was an employee of Pfizer Inc at the time these analyses were conducted and holds stock/stock options in Pfizer Inc.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>09</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>12</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>12</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
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<Day>2</Day>
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<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>8</Month>
<Day>22</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
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<ArticleId IdType="pii">annrheumdis-2016-210457</ArticleId>
<ArticleId IdType="doi">10.1136/annrheumdis-2016-210457</ArticleId>
<ArticleId IdType="pmc">PMC5530353</ArticleId>
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<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Corée du Sud</li>
<li>France</li>
<li>Japon</li>
<li>États-Unis</li>
</country>
<region><li>Alabama</li>
<li>Californie</li>
<li>Connecticut</li>
<li>Hambourg</li>
<li>Nouvelle-Galles du Sud</li>
<li>Oregon</li>
<li>Région capitale de Séoul</li>
<li>Texas</li>
<li>État de New York</li>
</region>
<settlement><li>Hambourg</li>
<li>Sydney</li>
<li>Séoul</li>
</settlement>
<orgName><li>Université nationale de Séoul</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Cohen, Stanley B" sort="Cohen, Stanley B" uniqKey="Cohen S" first="Stanley B" last="Cohen">Stanley B. Cohen</name>
</region>
<name sortKey="Charles Schoeman, Christina" sort="Charles Schoeman, Christina" uniqKey="Charles Schoeman C" first="Christina" last="Charles-Schoeman">Christina Charles-Schoeman</name>
<name sortKey="Curtis, Jeffrey R" sort="Curtis, Jeffrey R" uniqKey="Curtis J" first="Jeffrey R" last="Curtis">Jeffrey R. Curtis</name>
<name sortKey="Demasi, Ryan" sort="Demasi, Ryan" uniqKey="Demasi R" first="Ryan" last="Demasi">Ryan Demasi</name>
<name sortKey="Geier, Jamie" sort="Geier, Jamie" uniqKey="Geier J" first="Jamie" last="Geier">Jamie Geier</name>
<name sortKey="Kwok, Kenneth" sort="Kwok, Kenneth" uniqKey="Kwok K" first="Kenneth" last="Kwok">Kenneth Kwok</name>
<name sortKey="Riese, Richard" sort="Riese, Richard" uniqKey="Riese R" first="Richard" last="Riese">Richard Riese</name>
<name sortKey="Wang, Lisy" sort="Wang, Lisy" uniqKey="Wang L" first="Lisy" last="Wang">Lisy Wang</name>
<name sortKey="Winthrop, Kevin L" sort="Winthrop, Kevin L" uniqKey="Winthrop K" first="Kevin L" last="Winthrop">Kevin L. Winthrop</name>
</country>
<country name="Japon"><noRegion><name sortKey="Tanaka, Yoshiya" sort="Tanaka, Yoshiya" uniqKey="Tanaka Y" first="Yoshiya" last="Tanaka">Yoshiya Tanaka</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
</noRegion>
</country>
<country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Eun Bong" sort="Lee, Eun Bong" uniqKey="Lee E" first="Eun Bong" last="Lee">Eun Bong Lee</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Nash, Peter" sort="Nash, Peter" uniqKey="Nash P" first="Peter" last="Nash">Peter Nash</name>
</noRegion>
<name sortKey="Thirunavukkarasu, Krishan" sort="Thirunavukkarasu, Krishan" uniqKey="Thirunavukkarasu K" first="Krishan" last="Thirunavukkarasu">Krishan Thirunavukkarasu</name>
</country>
<country name="Allemagne"><region name="Hambourg"><name sortKey="Wollenhaupt, Jurgen" sort="Wollenhaupt, Jurgen" uniqKey="Wollenhaupt J" first="Jürgen" last="Wollenhaupt">Jürgen Wollenhaupt</name>
</region>
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