Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.
Identifieur interne : 000806 ( PubMed/Checkpoint ); précédent : 000805; suivant : 000807Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.
Auteurs : Yuho Okita [Australie] ; Alexandre N. Rcom-H'Cheo-Gauthier [Australie] ; Michael Goulding [Australie] ; Roger S. Chung [Australie] ; Peter Faller [France] ; Dean L. Pountney [Australie]Source :
- Frontiers in neuroscience [ 1662-4548 ] ; 2017.
Abstract
Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropriate copper binding can result in loss of protein function and Cu(I)/(II) redox cycling can generate reactive oxygen species. Copper accumulates in the brain with aging and has been shown to bind alpha-synuclein and initiate its aggregation, the primary aetiological factor in Parkinson's disease (PD), and other alpha-synucleinopathies. In PD, total tissue copper is decreased, including neuromelanin-bound copper and there is a reduction in copper transporter CTR-1. Conversely cerebrospinal fluid (CSF) copper is increased. MT-1/2 expression is increased in activated astrocytes in alpha-synucleinopathies, yet expression of the neuronal MT-3 isoform may be reduced. MTs have been implicated in inflammatory states to perform one-way exchange of copper, releasing free zinc and recent studies have found copper bound to alpha-synuclein is transferred to the MT-3 isoform in vitro and MT-3 is found bound to pathological alpha-synuclein aggregates in the alpha-synucleinopathy, multiple systems atrophy. Moreover, both MT and alpha-synuclein can be released and taken up by neural cells via specific receptors and so may interact both intra- and extra-cellularly. Here, we critically review the role of MTs in copper dyshomeostasis and alpha-synuclein aggregation, and their potential as biomarkers and therapeutic targets.
DOI: 10.3389/fnins.2017.00114
PubMed: 28420950
Affiliations:
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Rcom-H'Cheo-Gauthier</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Goulding, Michael" sort="Goulding, Michael" uniqKey="Goulding M" first="Michael" last="Goulding">Michael Goulding</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Chung, Roger S" sort="Chung, Roger S" uniqKey="Chung R" first="Roger S" last="Chung">Roger S. Chung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie UniversitySydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie UniversitySydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Faller, Peter" sort="Faller, Peter" uniqKey="Faller P" first="Peter" last="Faller">Peter Faller</name><affiliation wicri:level="1"><nlm:affiliation>Centre National de la Recherche Scientifique, Institut de Chimie UMR 7177, Université de StrasbourgStrasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique, Institut de Chimie UMR 7177, Université de StrasbourgStrasbourg</wicri:regionArea><wicri:noRegion>Université de StrasbourgStrasbourg</wicri:noRegion><wicri:noRegion>Université de StrasbourgStrasbourg</wicri:noRegion></affiliation></author><author><name sortKey="Pountney, Dean L" sort="Pountney, Dean L" uniqKey="Pountney D" first="Dean L" last="Pountney">Dean L. Pountney</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in neuroscience</title><idno type="ISSN">1662-4548</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropriate copper binding can result in loss of protein function and Cu(I)/(II) redox cycling can generate reactive oxygen species. Copper accumulates in the brain with aging and has been shown to bind alpha-synuclein and initiate its aggregation, the primary aetiological factor in Parkinson's disease (PD), and other alpha-synucleinopathies. In PD, total tissue copper is decreased, including neuromelanin-bound copper and there is a reduction in copper transporter CTR-1. Conversely cerebrospinal fluid (CSF) copper is increased. MT-1/2 expression is increased in activated astrocytes in alpha-synucleinopathies, yet expression of the neuronal MT-3 isoform may be reduced. MTs have been implicated in inflammatory states to perform one-way exchange of copper, releasing free zinc and recent studies have found copper bound to alpha-synuclein is transferred to the MT-3 isoform in vitro and MT-3 is found bound to pathological alpha-synuclein aggregates in the alpha-synucleinopathy, multiple systems atrophy. Moreover, both MT and alpha-synuclein can be released and taken up by neural cells via specific receptors and so may interact both intra- and extra-cellularly. Here, we critically review the role of MTs in copper dyshomeostasis and alpha-synuclein aggregation, and their potential as biomarkers and therapeutic targets.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28420950</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>19</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>16</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1662-4548</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Frontiers in neuroscience</Title><ISOAbbreviation>Front Neurosci</ISOAbbreviation></Journal><ArticleTitle>Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.</ArticleTitle><Pagination><MedlinePgn>114</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fnins.2017.00114</ELocationID><Abstract><AbstractText>Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropriate copper binding can result in loss of protein function and Cu(I)/(II) redox cycling can generate reactive oxygen species. Copper accumulates in the brain with aging and has been shown to bind alpha-synuclein and initiate its aggregation, the primary aetiological factor in Parkinson's disease (PD), and other alpha-synucleinopathies. In PD, total tissue copper is decreased, including neuromelanin-bound copper and there is a reduction in copper transporter CTR-1. Conversely cerebrospinal fluid (CSF) copper is increased. MT-1/2 expression is increased in activated astrocytes in alpha-synucleinopathies, yet expression of the neuronal MT-3 isoform may be reduced. MTs have been implicated in inflammatory states to perform one-way exchange of copper, releasing free zinc and recent studies have found copper bound to alpha-synuclein is transferred to the MT-3 isoform in vitro and MT-3 is found bound to pathological alpha-synuclein aggregates in the alpha-synucleinopathy, multiple systems atrophy. Moreover, both MT and alpha-synuclein can be released and taken up by neural cells via specific receptors and so may interact both intra- and extra-cellularly. Here, we critically review the role of MTs in copper dyshomeostasis and alpha-synuclein aggregation, and their potential as biomarkers and therapeutic targets.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Okita</LastName><ForeName>Yuho</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rcom-H'cheo-Gauthier</LastName><ForeName>Alexandre N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goulding</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Roger S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie UniversitySydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faller</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, Institut de Chimie UMR 7177, Université de StrasbourgStrasbourg, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Strasbourg Institute for Advanced StudyStrasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pountney</LastName><ForeName>Dean L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Neurosci</MedlineTA><NlmUniqueID>101478481</NlmUniqueID><ISSNLinking>1662-453X</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int Immunopharmacol. 2004 Oct;4(10-11):1307-18</RefSource><PMID Version="1">15313429</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Jan;19(1):60-7</RefSource><PMID Version="1">14743362</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2014 Apr 23-30;311(16):1670-83</RefSource><PMID Version="1">24756517</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1960 Dec;235:3460-5</RefSource><PMID Version="1">13750713</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2008 May 30;283(22):15349-58</RefSource><PMID Version="1">18334482</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Parkinsons Dis. 2013;3(1):1-11</RefSource><PMID Version="1">23938306</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurotox Res. 2011 Jan;19(1):115-22</RefSource><PMID Version="1">20039155</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Drug Discov. 2004 Mar;3(3):205-14</RefSource><PMID Version="1">15031734</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Oxid Med Cell Longev. 2014;2014:147251</RefSource><PMID Version="1">24672633</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Prog Histochem Cytochem. 2009;44(1):1-27</RefSource><PMID Version="1">19348909</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2015 Jul;21(7):802-7</RefSource><PMID Version="1">26099047</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:116-20</RefSource><PMID Version="1">17159794</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2016;51(1):81-95</RefSource><PMID Version="1">26836194</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2011 Sep 02;12(10):550</RefSource><PMID Version="1">21886184</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Drugs Aging. 2001;18(9):685-716</RefSource><PMID Version="1">11599635</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Trace Elem Res. 1992 Sep;34(3):237-48</RefSource><PMID Version="1">1384614</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2007 May 11;418(1):72-6</RefSource><PMID Version="1">17408857</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Mol Life Sci. 2012 Nov;69(21):3665-81</RefSource><PMID Version="1">22766972</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2013 Mar 12;80(11):1062-4</RefSource><PMID Version="1">23427326</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2014 Dec;29(14):1720-41</RefSource><PMID Version="1">25297524</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Death Dis. 2012 Jul 19;3:e350</RefSource><PMID Version="1">22825468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Metallomics. 2016 Sep 1;8(9):863-73</RefSource><PMID Version="1">27499330</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Neuroanat. 2015 Jul 08;9:91</RefSource><PMID Version="1">26217195</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 2009 Jan 12;1248:14-21</RefSource><PMID Version="1">19014916</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2016;51(3):637-56</RefSource><PMID Version="1">26923022</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Biochim Pol. 2010;57(4):561-6</RefSource><PMID Version="1">21060896</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Aging Cell. 2013 Oct;12(5):823-32</RefSource><PMID Version="1">23738916</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Chem Neuroanat. 2008 Sep;36(1):1-5</RefSource><PMID Version="1">18485665</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Sep 5;501(7465):45-51</RefSource><PMID Version="1">24005412</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Chem Biol. 2008 Apr;12(2):222-8</RefSource><PMID Version="1">18342639</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1987 Aug 1;2(8553):238-41</RefSource><PMID Version="1">2886715</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2014 Jan;75(1):127-37</RefSource><PMID Version="1">24242821</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol. 1998 Apr;274(4 Pt 2):F783-90</RefSource><PMID Version="1">9575904</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Genomics. 2013 Dec;14(8):486-501</RefSource><PMID Version="1">24532982</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 1996 Jun;13(2):219-22</RefSource><PMID Version="1">8640230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Histol Histopathol. 2012 Nov;27(11):1459-70</RefSource><PMID Version="1">23018245</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1998 Apr 9;392(6676):605-8</RefSource><PMID Version="1">9560156</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 1984 May;37(1):263-72</RefSource><PMID Version="1">6327055</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2015 Sep;81:76-92</RefSource><PMID Version="1">25497688</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Indian J Psychiatry. 2010 Apr;52(2):140-4</RefSource><PMID Version="1">20838501</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Neurol. 2012 Aug;25(4):429-32</RefSource><PMID Version="1">22772873</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chem Biol Interact. 1985 Nov;55(3):347-56</RefSource><PMID Version="1">4075441</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2014 Apr;35(4):858-66</RefSource><PMID Version="1">24176624</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1984 Apr 5-11;308(5959):513-9</RefSource><PMID Version="1">6323998</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2007 Nov;183(2):171-80</RefSource><PMID Version="1">17634932</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Talanta. 1998 Jun;46(2):243-54</RefSource><PMID Version="1">18967148</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S158-68</RefSource><PMID Version="1">20590831</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Top Behav Neurosci. 2015;22:271-301</RefSource><PMID Version="1">24839101</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2008 Jul 10;59(1):43-55</RefSource><PMID Version="1">18614028</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2017 Mar;32(3):319-324</RefSource><PMID Version="1">28233927</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res Mol Brain Res. 2005 Mar 24;134(1):67-75</RefSource><PMID Version="1">15790531</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genomics. 1990 Nov;8(3):513-8</RefSource><PMID Version="1">2286373</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2001 Jun;30(3):665-76</RefSource><PMID Version="1">11430801</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515</RefSource><PMID Version="1">27708160</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 2010 Mar 10;1319:118-30</RefSource><PMID Version="1">20026314</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2016 Jan 15;291(3):1092-102</RefSource><PMID Version="1">26598525</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Inorg Chem. 2013 Feb 4;52(3):1358-67</RefSource><PMID Version="1">23343468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Inorg Chem. 2015 May 18;54(10):4744-51</RefSource><PMID Version="1">25926427</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Chem Soc. 2008 Jun 18;130(24):7766-73</RefSource><PMID Version="1">18494470</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Traffic. 2014 Feb;15(2):230-44</RefSource><PMID Version="1">24152121</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Toxicology. 1981;20(4):275-9</RefSource><PMID Version="1">7314118</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Epidemiol. 2011 Jun;26 Suppl 1:S1-58</RefSource><PMID Version="1">21626386</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2004 Mar 12;279(11):10710-9</RefSource><PMID Version="1">14672949</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sci Rep. 2011;1:11</RefSource><PMID Version="1">22355530</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6333-7</RefSource><PMID Version="1">1631128</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Chem Biol. 2008 Jun;4(6):366-72</RefSource><PMID Version="1">18454142</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2016 Sep;93:115-20</RefSource><PMID Version="1">27185595</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2009 Apr 15;24(5):647-54</RefSource><PMID Version="1">19117366</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2002 Apr 1;22(7):2780-91</RefSource><PMID Version="1">11923443</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2004 Apr;18(6):637-47</RefSource><PMID Version="1">15054086</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Inorg Chem. 2011 Oct;16(7):1103-13</RefSource><PMID Version="1">21678079</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurochem Int. 2013 Sep;63(3):201-29</RefSource><PMID Version="1">23791710</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS J. 2010 Jul;277(14):2921-30</RefSource><PMID Version="1">20561054</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1999 Jun 15;340 ( Pt 3):821-8</RefSource><PMID Version="1">10359669</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Neurodegener. 2016 Apr 02;11:25</RefSource><PMID Version="1">27038906</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Pharm Biotechnol. 2013;14(4):408-13</RefSource><PMID Version="1">23590138</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010 Aug 11;5(8):e12030</RefSource><PMID Version="1">20711450</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cold Spring Harb Perspect Med. 2017 Feb 17;:null</RefSource><PMID Version="1">28213435</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Mol Life Sci. 2012 Nov;69(21):3683-700</RefSource><PMID Version="1">22722772</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Aging Neurosci. 2010 May 21;2:17</RefSource><PMID Version="1">20577640</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Metallomics. 2013 Jan;5(1):43-51</RefSource><PMID Version="1">23076575</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(6):e38545</RefSource><PMID Version="1">22701661</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chembiochem. 2015 Nov 2;16(16):2319-28</RefSource><PMID Version="1">26338312</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Mol Sci. 2017 Feb 22;18(2):</RefSource><PMID Version="1">28241427</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2017 Feb 7;23 (2):1-13</RefSource><PMID Version="1">28170377</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Neurosci. 2016 Dec 20;10 :570</RefSource><PMID Version="1">28066161</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurochem Int. 1993 Dec;23(6):561-6</RefSource><PMID Version="1">8281125</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mediators Inflamm. 2013;2013:342931</RefSource><PMID Version="1">23843682</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Trace Elem Med Biol. 2007;21 Suppl 1:35-9</RefSource><PMID Version="1">18039494</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Sci (Lond). 2016 Apr;130(8):565-74</RefSource><PMID Version="1">26957644</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 1989 Dec;9(12):5738-41</RefSource><PMID Version="1">2555705</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurotox Res. 2009 May;15(4):381-9</RefSource><PMID Version="1">19384571</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dev Biol. 1986 Dec;118(2):549-55</RefSource><PMID Version="1">3792622</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Free Radic Biol Med. 2011 Jun 1;50(11):1471-9</RefSource><PMID Version="1">21320589</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2009 Aug 13;460(7257):823-30</RefSource><PMID Version="1">19675642</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2012 May 25;149(5):1048-59</RefSource><PMID Version="1">22632969</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>ACS Chem Neurosci. 2016 Jan 20;7(1):119-29</RefSource><PMID Version="1">26481462</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Med Rep. 2015 Mar;11(3):1582-6</RefSource><PMID Version="1">25405524</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS J. 2010 Jul;277(14):2931-9</RefSource><PMID Version="1">20561053</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Postgrad Med J. 2004 Aug;80(946):452-8</RefSource><PMID Version="1">15299154</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2005 May;8(5):657-63</RefSource><PMID Version="1">15834418</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Nanomedicine. 2013;8:1477-88</RefSource><PMID Version="1">23620664</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2009 Oct 16;139(2):440.e1-2</RefSource><PMID Version="1">19837042</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Inorg Biochem. 2016 Oct;163:292-300</RefSource><PMID Version="1">27112900</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Cell Neurosci. 2015 Nov 12;9:437</RefSource><PMID Version="1">26778958</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2013 Jun 12;33(24):10154-64</RefSource><PMID Version="1">23761910</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Sci. 2007 Jun 15;257(1-2):221-39</RefSource><PMID Version="1">17462670</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2009 Jun 13;373(9680):2055-66</RefSource><PMID Version="1">19524782</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2012 Nov 16;338(6109):949-53</RefSource><PMID Version="1">23161999</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Pharmacol Toxicol. 2016 Nov 2;17 (1):55</RefSource><PMID Version="1">27802831</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurotherapeutics. 2015 Apr;12 (2):461-76</RefSource><PMID Version="1">25761970</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Toxicol Lett. 2003 Sep 30;144(2):151-7</RefSource><PMID Version="1">12927359</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurotoxicology. 2008 May;29(3):489-503</RefSource><PMID Version="1">18313142</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chem Res Toxicol. 2010 Feb 15;23(2):319-26</RefSource><PMID Version="1">19968254</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2000;920:16-27</RefSource><PMID Version="1">11193145</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cold Spring Harb Perspect Med. 2012 Feb;2(2):a009399</RefSource><PMID Version="1">22355802</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 1980 Feb 12;92(3):1052-69</RefSource><PMID Version="1">7362599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Biol Med (Maywood). 2006 Oct;231(9):1576-83</RefSource><PMID Version="1">17018883</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1981 Mar 25;256(6):2621-4</RefSource><PMID Version="1">7204370</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2004 Dec 8;24(49):11165-70</RefSource><PMID Version="1">15590933</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1984 Dec;81(23):7392-6</RefSource><PMID Version="1">6095291</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Sci. 2011 Apr 15;303(1-2):95-9</RefSource><PMID Version="1">21292280</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 2013 Feb;72(2):130-6</RefSource><PMID Version="1">23334596</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurogenetics. 2011 Nov;12(4):295-305</RefSource><PMID Version="1">21800131</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurochem Int. 2014 Jan;65:40-8</RefSource><PMID Version="1">24389356</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Metallomics. 2015 Mar;7(3):395-404</RefSource><PMID Version="1">25648629</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Med Hypotheses. 2006;67(2):251-69</RefSource><PMID Version="1">16513287</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Inorg Chem. 2014 May 5;53(9):4350-8</RefSource><PMID Version="1">24725094</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Neurobiol. 2004 Aug;30(1):1-21</RefSource><PMID Version="1">15247485</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2003 Apr 15;23(8):3336-42</RefSource><PMID Version="1">12716941</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2003 Sep 11;39(6):889-909</RefSource><PMID Version="1">12971891</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Physiol Rev. 2007 Jul;87(3):1011-46</RefSource><PMID Version="1">17615395</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">copper</Keyword><Keyword MajorTopicYN="N">dementia with lewy bodies</Keyword><Keyword MajorTopicYN="N">metallothionein</Keyword><Keyword MajorTopicYN="N">multiple system atrophy</Keyword><Keyword MajorTopicYN="N">α-synuclein</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>10</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28420950</ArticleId><ArticleId IdType="doi">10.3389/fnins.2017.00114</ArticleId><ArticleId IdType="pmc">PMC5380005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Okita, Yuho" sort="Okita, Yuho" uniqKey="Okita Y" first="Yuho" last="Okita">Yuho Okita</name></noRegion><name sortKey="Chung, Roger S" sort="Chung, Roger S" uniqKey="Chung R" first="Roger S" last="Chung">Roger S. Chung</name><name sortKey="Goulding, Michael" sort="Goulding, Michael" uniqKey="Goulding M" first="Michael" last="Goulding">Michael Goulding</name><name sortKey="Pountney, Dean L" sort="Pountney, Dean L" uniqKey="Pountney D" first="Dean L" last="Pountney">Dean L. Pountney</name><name sortKey="Rcom H Cheo Gauthier, Alexandre N" sort="Rcom H Cheo Gauthier, Alexandre N" uniqKey="Rcom H Cheo Gauthier A" first="Alexandre N" last="Rcom-H'Cheo-Gauthier">Alexandre N. Rcom-H'Cheo-Gauthier</name></country><country name="France"><noRegion><name sortKey="Faller, Peter" sort="Faller, Peter" uniqKey="Faller P" first="Peter" last="Faller">Peter Faller</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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