Panobinostat monotherapy and combination therapy in patients with acute myeloid leukemia, results from two clinical trials.
Identifieur interne : 000642 ( PubMed/Checkpoint ); précédent : 000641; suivant : 000643Panobinostat monotherapy and combination therapy in patients with acute myeloid leukemia, results from two clinical trials.
Auteurs : Richard Schlenk [Allemagne] ; Jürgen Krauter [Allemagne] ; Emmanuel Raffoux [France] ; Karl-Anton Kreuzer [Allemagne] ; Markus Schaich [Allemagne] ; Lucien Noens [Belgique] ; Thomas Pabst [Suisse] ; Madhuri Vusirikala [États-Unis] ; Didier Bouscary [France] ; Andrew Spencer [Australie] ; Anna Candoni [Italie] ; Jorge Sierra Gil [Espagne] ; Noah Berkowitz [États-Unis] ; Hans-Jochen Weber [Suisse] ; Oliver Ottmann [Royaume-Uni]Source :
- Haematologica [ 1592-8721 ] ; 2017.
DOI: 10.3324/haematol.2017.172411
PubMed: 29051280
Affiliations:
- Allemagne, Australie, Belgique, Espagne, France, Italie, Royaume-Uni, Suisse, États-Unis
- Bade-Wurtemberg, Canton de Berne, District de Karlsruhe, New Jersey, Île-de-France
- Berne, Heidelberg, Paris
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National center for tumor diseases Heidelberg, Heidelberg, Germany; richard.schlenk@nct-heidelberg.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>NCT-Trial Center, National center for tumor diseases Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Krauter, Jurgen" sort="Krauter, Jurgen" uniqKey="Krauter J" first="Jürgen" last="Krauter">Jürgen Krauter</name><affiliation wicri:level="1"><nlm:affiliation>Department Hematology and Oncology, Braunschweig Municipal Hospital, Braunschweig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Hematology and Oncology, Braunschweig Municipal Hospital, 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University at Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University at Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Schaich, Markus" sort="Schaich, Markus" uniqKey="Schaich M" first="Markus" last="Schaich">Markus Schaich</name><affiliation wicri:level="1"><nlm:affiliation>Hämatologie, Onkologie und Palliativmedizin, Rems-Murr-Kliniken, Winnenden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hämatologie, Onkologie und Palliativmedizin, Rems-Murr-Kliniken, Winnenden</wicri:regionArea><wicri:noRegion>Winnenden</wicri:noRegion><wicri:noRegion>Winnenden</wicri:noRegion><wicri:noRegion>Winnenden</wicri:noRegion></affiliation></author><author><name sortKey="Noens, Lucien" sort="Noens, Lucien" uniqKey="Noens L" first="Lucien" last="Noens">Lucien Noens</name><affiliation wicri:level="1"><nlm:affiliation>Universitair Ziekenhuis, Gent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Universitair Ziekenhuis, Gent</wicri:regionArea><wicri:noRegion>Gent</wicri:noRegion></affiliation></author><author><name sortKey="Pabst, Thomas" sort="Pabst, Thomas" uniqKey="Pabst T" first="Thomas" last="Pabst">Thomas Pabst</name><affiliation wicri:level="3"><nlm:affiliation>Inselspital, Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Inselspital, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Vusirikala, Madhuri" sort="Vusirikala, Madhuri" uniqKey="Vusirikala M" first="Madhuri" last="Vusirikala">Madhuri Vusirikala</name><affiliation wicri:level="1"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas TX, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas TX</wicri:regionArea><wicri:noRegion>Dallas TX</wicri:noRegion></affiliation></author><author><name sortKey="Bouscary, Didier" sort="Bouscary, Didier" uniqKey="Bouscary D" first="Didier" last="Bouscary">Didier Bouscary</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation wicri:level="1"><nlm:affiliation>The Alfred Hospital, Melbourne VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Alfred Hospital, Melbourne VIC</wicri:regionArea><wicri:noRegion>Melbourne VIC</wicri:noRegion></affiliation></author><author><name sortKey="Candoni, Anna" sort="Candoni, Anna" uniqKey="Candoni A" first="Anna" last="Candoni">Anna Candoni</name><affiliation wicri:level="1"><nlm:affiliation>Az.Osped.-Universit.Santa Maria della Misericordia di Udine Udine, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Az.Osped.-Universit.Santa Maria della Misericordia di Udine Udine</wicri:regionArea></affiliation></author><author><name sortKey="Sierra Gil, Jorge" sort="Sierra Gil, Jorge" uniqKey="Sierra Gil J" first="Jorge" last="Sierra Gil">Jorge Sierra Gil</name><affiliation wicri:level="1"><nlm:affiliation>Hospital de la Santa Creu i Sant Pau Autonomous University of Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital de la Santa Creu i Sant Pau Autonomous University of Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Berkowitz, Noah" sort="Berkowitz, Noah" uniqKey="Berkowitz N" first="Noah" last="Berkowitz">Noah Berkowitz</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceutical Corp, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceutical Corp, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Weber, Hans Jochen" sort="Weber, Hans Jochen" uniqKey="Weber H" first="Hans-Jochen" last="Weber">Hans-Jochen Weber</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharma AG, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Pharma AG, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Ottmann, Oliver" sort="Ottmann, Oliver" uniqKey="Ottmann O" first="Oliver" last="Ottmann">Oliver Ottmann</name><affiliation wicri:level="1"><nlm:affiliation>Haematology, Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematology, Division of Cancer and Genetics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author></analytic><series><title level="j">Haematologica</title><idno type="eISSN">1592-8721</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29051280</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>20</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1592-8721</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Oct</Month><Day>19</Day></PubDate></JournalIssue><Title>Haematologica</Title><ISOAbbreviation>Haematologica</ISOAbbreviation></Journal><ArticleTitle>Panobinostat monotherapy and combination therapy in patients with acute myeloid leukemia, results from two clinical trials.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">haematol.2017.172411</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3324/haematol.2017.172411</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schlenk</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>NCT-Trial Center, National center for tumor diseases Heidelberg, Heidelberg, Germany; richard.schlenk@nct-heidelberg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krauter</LastName><ForeName>Jürgen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department Hematology and Oncology, Braunschweig Municipal Hospital, Braunschweig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raffoux</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Hopital Saint Louis, Service Hematologie adulte, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kreuzer</LastName><ForeName>Karl-Anton</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Department I of Internal Medicine, University at Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schaich</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hämatologie, Onkologie und Palliativmedizin, Rems-Murr-Kliniken, Winnenden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noens</LastName><ForeName>Lucien</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Universitair Ziekenhuis, Gent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pabst</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Inselspital, Bern, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vusirikala</LastName><ForeName>Madhuri</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Texas Southwestern Medical Center, Dallas TX, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouscary</LastName><ForeName>Didier</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spencer</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Alfred Hospital, Melbourne VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Candoni</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Az.Osped.-Universit.Santa Maria della Misericordia di Udine Udine, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sierra Gil</LastName><ForeName>Jorge</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital de la Santa Creu i Sant Pau Autonomous University of Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berkowitz</LastName><ForeName>Noah</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Novartis Pharmaceutical Corp, East Hanover, NJ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weber</LastName><ForeName>Hans-Jochen</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Novartis Pharma AG, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ottmann</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Haematology, Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Haematologica</MedlineTA><NlmUniqueID>0417435</NlmUniqueID><ISSNLinking>0390-6078</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute Myeloid Leukemia</Keyword><Keyword MajorTopicYN="N">Leukemic Stem Cell</Keyword><Keyword MajorTopicYN="N">deacetylase inhibitor</Keyword><Keyword MajorTopicYN="N">panobinostat</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29051280</ArticleId><ArticleId IdType="pii">haematol.2017.172411</ArticleId><ArticleId IdType="doi">10.3324/haematol.2017.172411</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Canton de Berne</li><li>District de Karlsruhe</li><li>New Jersey</li><li>Île-de-France</li></region><settlement><li>Berne</li><li>Heidelberg</li><li>Paris</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Schlenk, Richard" sort="Schlenk, Richard" uniqKey="Schlenk R" first="Richard" last="Schlenk">Richard Schlenk</name></region><name sortKey="Krauter, Jurgen" sort="Krauter, Jurgen" uniqKey="Krauter J" first="Jürgen" last="Krauter">Jürgen Krauter</name><name sortKey="Kreuzer, Karl Anton" sort="Kreuzer, Karl Anton" uniqKey="Kreuzer K" first="Karl-Anton" last="Kreuzer">Karl-Anton Kreuzer</name><name sortKey="Schaich, Markus" sort="Schaich, Markus" uniqKey="Schaich M" first="Markus" last="Schaich">Markus Schaich</name></country><country name="France"><region name="Île-de-France"><name sortKey="Raffoux, Emmanuel" sort="Raffoux, Emmanuel" uniqKey="Raffoux E" first="Emmanuel" last="Raffoux">Emmanuel Raffoux</name></region><name sortKey="Bouscary, Didier" sort="Bouscary, Didier" uniqKey="Bouscary D" first="Didier" last="Bouscary">Didier Bouscary</name></country><country name="Belgique"><noRegion><name sortKey="Noens, Lucien" sort="Noens, Lucien" uniqKey="Noens L" first="Lucien" last="Noens">Lucien Noens</name></noRegion></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Pabst, Thomas" sort="Pabst, Thomas" uniqKey="Pabst T" first="Thomas" last="Pabst">Thomas Pabst</name></region><name sortKey="Weber, Hans Jochen" sort="Weber, Hans Jochen" uniqKey="Weber H" first="Hans-Jochen" last="Weber">Hans-Jochen Weber</name></country><country name="États-Unis"><noRegion><name sortKey="Vusirikala, Madhuri" sort="Vusirikala, Madhuri" uniqKey="Vusirikala M" first="Madhuri" last="Vusirikala">Madhuri Vusirikala</name></noRegion><name sortKey="Berkowitz, Noah" sort="Berkowitz, Noah" uniqKey="Berkowitz N" first="Noah" last="Berkowitz">Noah Berkowitz</name></country><country name="Australie"><noRegion><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Candoni, Anna" sort="Candoni, Anna" uniqKey="Candoni A" first="Anna" last="Candoni">Anna Candoni</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Sierra Gil, Jorge" sort="Sierra Gil, Jorge" uniqKey="Sierra Gil J" first="Jorge" last="Sierra Gil">Jorge Sierra Gil</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Ottmann, Oliver" sort="Ottmann, Oliver" uniqKey="Ottmann O" first="Oliver" last="Ottmann">Oliver Ottmann</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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