Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution.
Identifieur interne : 000594 ( PubMed/Checkpoint ); précédent : 000593; suivant : 000595Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution.
Auteurs : Gavin G. Rutledge [Royaume-Uni] ; Ulrike Böhme [Royaume-Uni] ; Mandy Sanders [Royaume-Uni] ; Adam J. Reid [Royaume-Uni] ; James A. Cotton [Royaume-Uni] ; Oumou Maiga-Ascofare [Mali] ; Abdoulaye A. Djimdé [Royaume-Uni] ; Tobias O. Apinjoh ; Lucas Amenga-Etego [Ghana] ; Magnus Manske [Royaume-Uni] ; John W. Barnwell [États-Unis] ; François Renaud [France] ; Benjamin Ollomo [Gabon] ; Franck Prugnolle [France] ; Nicholas M. Anstey [Australie] ; Sarah Auburn [Australie] ; Ric N. Price [Australie] ; James S. Mccarthy [Australie] ; Dominic P. Kwiatkowski [Royaume-Uni] ; Chris I. Newbold [Royaume-Uni] ; Matthew Berriman [Royaume-Uni] ; Thomas D. Otto [Royaume-Uni]Source :
- Nature [ 1476-4687 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Génome, Plasmodium malariae, Plasmodium ovale.
- parasitologie : Paludisme, Pan troglodytes, Érythrocytes.
- Animaux, Femelle, Génomique, Humains, Phylogénie, Évolution moléculaire.
English descriptors
- KwdEn :
- MESH :
- genetics : Genome, Plasmodium malariae, Plasmodium ovale.
- parasitology : Erythrocytes, Malaria, Pan troglodytes.
- Animals, Evolution, Molecular, Female, Genomics, Humans, Phylogeny.
Abstract
Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: P. malariae and two P. ovale species (P. o. curtisi and P. o. wallikeri). These species are prevalent across most regions in which malaria is endemic and are often undetectable by light microscopy, rendering their study in human populations difficult. The exact evolutionary relationship of these species to the other human-infective species has been contested. Using a new reference genome for P. malariae and a manually curated draft P. o. curtisi genome, we are now able to accurately place these species within the Plasmodium phylogeny. Sequencing of a P. malariae relative that infects chimpanzees reveals similar signatures of selection in the P. malariae lineage to another Plasmodium lineage shown to be capable of colonization of both human and chimpanzee hosts. Molecular dating suggests that these host adaptations occurred over similar evolutionary timescales. In addition to the core genome that is conserved between species, differences in gene content can be linked to their specific biology. The genome suggests that P. malariae expresses a family of heterodimeric proteins on its surface that have structural similarities to a protein crucial for invasion of red blood cells. The data presented here provide insight into the evolution of the Plasmodium genus as a whole.
DOI: 10.1038/nature21038
PubMed: 28117441
Affiliations:
- Australie, France, Gabon, Ghana, Mali, Royaume-Uni, États-Unis
- Languedoc-Roussillon, Occitanie (région administrative)
- Montpellier
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Links to Exploration step
pubmed:28117441Le document en format XML
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Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Tropical Medicine Laboratory, QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Clinical Tropical Medicine Laboratory, QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Kwiatkowski, Dominic P" sort="Kwiatkowski, Dominic P" uniqKey="Kwiatkowski D" first="Dominic P" last="Kwiatkowski">Dominic P. Kwiatkowski</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Newbold, Chris I" sort="Newbold, Chris I" uniqKey="Newbold C" first="Chris I" last="Newbold">Chris I. Newbold</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Berriman, Matthew" sort="Berriman, Matthew" uniqKey="Berriman M" first="Matthew" last="Berriman">Matthew Berriman</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. 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Rutledge</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Bohme, Ulrike" sort="Bohme, Ulrike" uniqKey="Bohme U" first="Ulrike" last="Böhme">Ulrike Böhme</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Sanders, Mandy" sort="Sanders, Mandy" uniqKey="Sanders M" first="Mandy" last="Sanders">Mandy Sanders</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Reid, Adam J" sort="Reid, Adam J" uniqKey="Reid A" first="Adam J" last="Reid">Adam J. Reid</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Cotton, James A" sort="Cotton, James A" uniqKey="Cotton J" first="James A" last="Cotton">James A. Cotton</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Maiga Ascofare, Oumou" sort="Maiga Ascofare, Oumou" uniqKey="Maiga Ascofare O" first="Oumou" last="Maiga-Ascofare">Oumou Maiga-Ascofare</name><affiliation wicri:level="1"><nlm:affiliation>Malaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako BP E.2528, Mali.</nlm:affiliation><country xml:lang="fr">Mali</country><wicri:regionArea>Malaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako BP E.2528</wicri:regionArea><wicri:noRegion>Bamako BP E.2528</wicri:noRegion></affiliation></author><author><name sortKey="Djimde, Abdoulaye A" sort="Djimde, Abdoulaye A" uniqKey="Djimde A" first="Abdoulaye A" last="Djimdé">Abdoulaye A. Djimdé</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Apinjoh, Tobias O" sort="Apinjoh, Tobias O" uniqKey="Apinjoh T" first="Tobias O" last="Apinjoh">Tobias O. Apinjoh</name><affiliation><nlm:affiliation>University of Buea, Post Office Box 63, Buea, South West Region, Republic of Cameroon.</nlm:affiliation><wicri:noCountry code="subField">Republic of Cameroon</wicri:noCountry></affiliation></author><author><name sortKey="Amenga Etego, Lucas" sort="Amenga Etego, Lucas" uniqKey="Amenga Etego L" first="Lucas" last="Amenga-Etego">Lucas Amenga-Etego</name><affiliation wicri:level="1"><nlm:affiliation>Navrongo Health Research Centre, Post Office Box 114, Navrongo, Upper East Region, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Navrongo Health Research Centre, Post Office Box 114, Navrongo, Upper East Region</wicri:regionArea><wicri:noRegion>Upper East Region</wicri:noRegion></affiliation></author><author><name sortKey="Manske, Magnus" sort="Manske, Magnus" uniqKey="Manske M" first="Magnus" last="Manske">Magnus Manske</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Barnwell, John W" sort="Barnwell, John W" uniqKey="Barnwell J" first="John W" last="Barnwell">John W. Barnwell</name><affiliation wicri:level="1"><nlm:affiliation>Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Disease Control and Prevention, Atlanta, Georgia 30333</wicri:regionArea><wicri:noRegion>Georgia 30333</wicri:noRegion></affiliation></author><author><name sortKey="Renaud, Francois" sort="Renaud, Francois" uniqKey="Renaud F" first="François" last="Renaud">François Renaud</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire MIVEGEC (UM1-CNRS-IRD), 34394 Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire MIVEGEC (UM1-CNRS-IRD), 34394 Montpellier</wicri:regionArea><wicri:noRegion>34394 Montpellier</wicri:noRegion><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Ollomo, Benjamin" sort="Ollomo, Benjamin" uniqKey="Ollomo B" first="Benjamin" last="Ollomo">Benjamin Ollomo</name><affiliation wicri:level="1"><nlm:affiliation>Centre International de Recherches Médicales de Franceville, BP 709 Franceville, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre International de Recherches Médicales de Franceville, BP 709 Franceville</wicri:regionArea><wicri:noRegion>BP 709 Franceville</wicri:noRegion></affiliation></author><author><name sortKey="Prugnolle, Franck" sort="Prugnolle, Franck" uniqKey="Prugnolle F" first="Franck" last="Prugnolle">Franck Prugnolle</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire MIVEGEC (UM1-CNRS-IRD), 34394 Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire MIVEGEC (UM1-CNRS-IRD), 34394 Montpellier</wicri:regionArea><wicri:noRegion>34394 Montpellier</wicri:noRegion><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Anstey, Nicholas M" sort="Anstey, Nicholas M" uniqKey="Anstey N" first="Nicholas M" last="Anstey">Nicholas M. Anstey</name><affiliation wicri:level="1"><nlm:affiliation>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810</wicri:regionArea><wicri:noRegion>Northern Territory 0810</wicri:noRegion></affiliation></author><author><name sortKey="Auburn, Sarah" sort="Auburn, Sarah" uniqKey="Auburn S" first="Sarah" last="Auburn">Sarah Auburn</name><affiliation wicri:level="1"><nlm:affiliation>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810</wicri:regionArea><wicri:noRegion>Northern Territory 0810</wicri:noRegion></affiliation></author><author><name sortKey="Price, Ric N" sort="Price, Ric N" uniqKey="Price R" first="Ric N" last="Price">Ric N. Price</name><affiliation wicri:level="1"><nlm:affiliation>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810</wicri:regionArea><wicri:noRegion>Northern Territory 0810</wicri:noRegion></affiliation></author><author><name sortKey="Mccarthy, James S" sort="Mccarthy, James S" uniqKey="Mccarthy J" first="James S" last="Mccarthy">James S. Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Tropical Medicine Laboratory, QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Clinical Tropical Medicine Laboratory, QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Kwiatkowski, Dominic P" sort="Kwiatkowski, Dominic P" uniqKey="Kwiatkowski D" first="Dominic P" last="Kwiatkowski">Dominic P. Kwiatkowski</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Newbold, Chris I" sort="Newbold, Chris I" uniqKey="Newbold C" first="Chris I" last="Newbold">Chris I. Newbold</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Berriman, Matthew" sort="Berriman, Matthew" uniqKey="Berriman M" first="Matthew" last="Berriman">Matthew Berriman</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. Otto</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature</title><idno type="eISSN">1476-4687</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Erythrocytes (parasitology)</term><term>Evolution, Molecular</term><term>Female</term><term>Genome (genetics)</term><term>Genomics</term><term>Humans</term><term>Malaria (parasitology)</term><term>Pan troglodytes (parasitology)</term><term>Phylogeny</term><term>Plasmodium malariae (genetics)</term><term>Plasmodium ovale (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Génome (génétique)</term><term>Génomique</term><term>Humains</term><term>Paludisme (parasitologie)</term><term>Pan troglodytes (parasitologie)</term><term>Phylogénie</term><term>Plasmodium malariae (génétique)</term><term>Plasmodium ovale (génétique)</term><term>Érythrocytes (parasitologie)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome</term><term>Plasmodium malariae</term><term>Plasmodium ovale</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Génome</term><term>Plasmodium malariae</term><term>Plasmodium ovale</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme</term><term>Pan troglodytes</term><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Erythrocytes</term><term>Malaria</term><term>Pan troglodytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Evolution, Molecular</term><term>Female</term><term>Genomics</term><term>Humans</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Génomique</term><term>Humains</term><term>Phylogénie</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: P. malariae and two P. ovale species (P. o. curtisi and P. o. wallikeri). These species are prevalent across most regions in which malaria is endemic and are often undetectable by light microscopy, rendering their study in human populations difficult. The exact evolutionary relationship of these species to the other human-infective species has been contested. Using a new reference genome for P. malariae and a manually curated draft P. o. curtisi genome, we are now able to accurately place these species within the Plasmodium phylogeny. Sequencing of a P. malariae relative that infects chimpanzees reveals similar signatures of selection in the P. malariae lineage to another Plasmodium lineage shown to be capable of colonization of both human and chimpanzee hosts. Molecular dating suggests that these host adaptations occurred over similar evolutionary timescales. In addition to the core genome that is conserved between species, differences in gene content can be linked to their specific biology. The genome suggests that P. malariae expresses a family of heterodimeric proteins on its surface that have structural similarities to a protein crucial for invasion of red blood cells. The data presented here provide insight into the evolution of the Plasmodium genus as a whole.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28117441</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>24</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>10</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN><JournalIssue CitedMedium="Internet"><Volume>542</Volume><Issue>7639</Issue><PubDate><Year>2017</Year><Month>02</Month><Day>02</Day></PubDate></JournalIssue><Title>Nature</Title><ISOAbbreviation>Nature</ISOAbbreviation></Journal><ArticleTitle>Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution.</ArticleTitle><Pagination><MedlinePgn>101-104</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/nature21038</ELocationID><Abstract><AbstractText>Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: P. malariae and two P. ovale species (P. o. curtisi and P. o. wallikeri). These species are prevalent across most regions in which malaria is endemic and are often undetectable by light microscopy, rendering their study in human populations difficult. The exact evolutionary relationship of these species to the other human-infective species has been contested. Using a new reference genome for P. malariae and a manually curated draft P. o. curtisi genome, we are now able to accurately place these species within the Plasmodium phylogeny. Sequencing of a P. malariae relative that infects chimpanzees reveals similar signatures of selection in the P. malariae lineage to another Plasmodium lineage shown to be capable of colonization of both human and chimpanzee hosts. Molecular dating suggests that these host adaptations occurred over similar evolutionary timescales. In addition to the core genome that is conserved between species, differences in gene content can be linked to their specific biology. The genome suggests that P. malariae expresses a family of heterodimeric proteins on its surface that have structural similarities to a protein crucial for invasion of red blood cells. The data presented here provide insight into the evolution of the Plasmodium genus as a whole.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rutledge</LastName><ForeName>Gavin G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Böhme</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanders</LastName><ForeName>Mandy</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reid</LastName><ForeName>Adam J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cotton</LastName><ForeName>James A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maiga-Ascofare</LastName><ForeName>Oumou</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Malaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako BP E.2528, Mali.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Infection Research, 20359 Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djimdé</LastName><ForeName>Abdoulaye A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Malaria Research and Training Center, University of Science, Techniques, and Technologies of Bamako, Bamako BP E.2528, Mali.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Apinjoh</LastName><ForeName>Tobias O</ForeName><Initials>TO</Initials><AffiliationInfo><Affiliation>University of Buea, Post Office Box 63, Buea, South West Region, Republic of Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amenga-Etego</LastName><ForeName>Lucas</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Navrongo Health Research Centre, Post Office Box 114, Navrongo, Upper East Region, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manske</LastName><ForeName>Magnus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barnwell</LastName><ForeName>John W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Renaud</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Laboratoire MIVEGEC (UM1-CNRS-IRD), 34394 Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ollomo</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Centre International de Recherches Médicales de Franceville, BP 709 Franceville, Gabon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prugnolle</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Laboratoire MIVEGEC (UM1-CNRS-IRD), 34394 Montpellier, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre International de Recherches Médicales de Franceville, BP 709 Franceville, Gabon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anstey</LastName><ForeName>Nicholas M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auburn</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>Ric N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory 0810, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>James S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Clinical Tropical Medicine Laboratory, QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland 4006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwiatkowski</LastName><ForeName>Dominic P</ForeName><Initials>DP</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newbold</LastName><ForeName>Chris I</ForeName><Initials>CI</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berriman</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Otto</LastName><ForeName>Thomas D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>091625</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nature</MedlineTA><NlmUniqueID>0410462</NlmUniqueID><ISSNLinking>0028-0836</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2014 Aug;46(8):850-7</RefSource><PMID Version="1">25038751</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Microbiol Rev. 2005 Jul;18(3):570-81</RefSource><PMID Version="1">16020691</PMID></CommentsCorrections><CommentsCorrections 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Jan;12(1):198-202</RefSource><PMID Version="1">11779845</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Cell Host Microbe. 2017 Mar 8;21(3):310-312</RefSource><PMID Version="1">28279339</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004912" MajorTopicYN="N">Erythrocytes</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="Y">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016678" MajorTopicYN="N">Genome</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D023281" MajorTopicYN="N">Genomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002679" MajorTopicYN="N">Pan troglodytes</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010965" MajorTopicYN="N">Plasmodium malariae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D041122" MajorTopicYN="N">Plasmodium ovale</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>04</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28117441</ArticleId><ArticleId IdType="pii">nature21038</ArticleId><ArticleId IdType="doi">10.1038/nature21038</ArticleId><ArticleId IdType="pmc">PMC5326575</ArticleId><ArticleId IdType="mid">EMS71595</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Gabon</li><li>Ghana</li><li>Mali</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement></list><tree><noCountry><name sortKey="Apinjoh, Tobias O" sort="Apinjoh, Tobias O" uniqKey="Apinjoh T" first="Tobias O" last="Apinjoh">Tobias O. Apinjoh</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Rutledge, Gavin G" sort="Rutledge, Gavin G" uniqKey="Rutledge G" first="Gavin G" last="Rutledge">Gavin G. Rutledge</name></noRegion><name sortKey="Berriman, Matthew" sort="Berriman, Matthew" uniqKey="Berriman M" first="Matthew" last="Berriman">Matthew Berriman</name><name sortKey="Bohme, Ulrike" sort="Bohme, Ulrike" uniqKey="Bohme U" first="Ulrike" last="Böhme">Ulrike Böhme</name><name sortKey="Cotton, James A" sort="Cotton, James A" uniqKey="Cotton J" first="James A" last="Cotton">James A. Cotton</name><name sortKey="Djimde, Abdoulaye A" sort="Djimde, Abdoulaye A" uniqKey="Djimde A" first="Abdoulaye A" last="Djimdé">Abdoulaye A. Djimdé</name><name sortKey="Kwiatkowski, Dominic P" sort="Kwiatkowski, Dominic P" uniqKey="Kwiatkowski D" first="Dominic P" last="Kwiatkowski">Dominic P. Kwiatkowski</name><name sortKey="Manske, Magnus" sort="Manske, Magnus" uniqKey="Manske M" first="Magnus" last="Manske">Magnus Manske</name><name sortKey="Newbold, Chris I" sort="Newbold, Chris I" uniqKey="Newbold C" first="Chris I" last="Newbold">Chris I. Newbold</name><name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. Otto</name><name sortKey="Reid, Adam J" sort="Reid, Adam J" uniqKey="Reid A" first="Adam J" last="Reid">Adam J. Reid</name><name sortKey="Sanders, Mandy" sort="Sanders, Mandy" uniqKey="Sanders M" first="Mandy" last="Sanders">Mandy Sanders</name></country><country name="Mali"><noRegion><name sortKey="Maiga Ascofare, Oumou" sort="Maiga Ascofare, Oumou" uniqKey="Maiga Ascofare O" first="Oumou" last="Maiga-Ascofare">Oumou Maiga-Ascofare</name></noRegion></country><country name="Ghana"><noRegion><name sortKey="Amenga Etego, Lucas" sort="Amenga Etego, Lucas" uniqKey="Amenga Etego L" first="Lucas" last="Amenga-Etego">Lucas Amenga-Etego</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Barnwell, John W" sort="Barnwell, John W" uniqKey="Barnwell J" first="John W" last="Barnwell">John W. Barnwell</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Renaud, Francois" sort="Renaud, Francois" uniqKey="Renaud F" first="François" last="Renaud">François Renaud</name></region><name sortKey="Prugnolle, Franck" sort="Prugnolle, Franck" uniqKey="Prugnolle F" first="Franck" last="Prugnolle">Franck Prugnolle</name></country><country name="Gabon"><noRegion><name sortKey="Ollomo, Benjamin" sort="Ollomo, Benjamin" uniqKey="Ollomo B" first="Benjamin" last="Ollomo">Benjamin Ollomo</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Anstey, Nicholas M" sort="Anstey, Nicholas M" uniqKey="Anstey N" first="Nicholas M" last="Anstey">Nicholas M. Anstey</name></noRegion><name sortKey="Auburn, Sarah" sort="Auburn, Sarah" uniqKey="Auburn S" first="Sarah" last="Auburn">Sarah Auburn</name><name sortKey="Mccarthy, James S" sort="Mccarthy, James S" uniqKey="Mccarthy J" first="James S" last="Mccarthy">James S. Mccarthy</name><name sortKey="Price, Ric N" sort="Price, Ric N" uniqKey="Price R" first="Ric N" last="Price">Ric N. Price</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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