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Repigmentation in vitiligo: position paper of the Vitiligo Global Issues Consensus Conference.

Identifieur interne : 000447 ( PubMed/Checkpoint ); précédent : 000446; suivant : 000448

Repigmentation in vitiligo: position paper of the Vitiligo Global Issues Consensus Conference.

Auteurs : Emily Y. Gan [Singapour] ; Viktoria Eleftheriadou [Royaume-Uni] ; Samia Esmat [Égypte] ; Iltefat Hamzavi [États-Unis] ; Thierry Passeron [France] ; Markus Böhm [Allemagne] ; Tag Anbar [Égypte] ; Boon Kee Goh [Singapour] ; Cheng-Che E. Lan [Taïwan] ; Harvey Lui [Canada] ; M. Ramam [Inde] ; Noufal Raboobee [Afrique du Sud] ; Ichiro Katayama [Japon] ; Tamio Suzuki [Japon] ; Davinder Parsad [Inde] ; Vaneeta Seth [États-Unis] ; Henry W. Lim [États-Unis] ; Nanja Van Geel [Belgique] ; Sanjeev Mulekar [Arabie saoudite] ; John Harris [États-Unis] ; Richard Wittal [Australie] ; Laila Benzekri [Maroc] ; Yvon Gauthier [France] ; Prasad Kumarasinghe [Australie] ; Steven T G. Thng [Singapour] ; Caio Cesar Silva De Castro [Brésil] ; Marwa Abdallah [Égypte] ; Charlotte Vrijman [Pays-Bas] ; Marcel Bekkenk [Pays-Bas] ; Julien Seneschal [France] ; Amit G. Pandya [États-Unis] ; Khaled Ezzedine [France] ; Mauro Picardo [Italie] ; Alain Taïeb [France]

Source :

RBID : pubmed:27864868

Abstract

The Vitiligo Global Issues Consensus Conference (VGICC), through an international e-Delphi consensus, concluded that 'repigmentation' and 'maintenance of gained repigmentation' are essential core outcome measures in future vitiligo trials. This VGICC position paper addresses these core topics in two sections and includes an atlas depicting vitiligo repigmentation patterns and color match. The first section delineates mechanisms and characteristics of vitiligo repigmentation, and the second section summarizes the outcomes of international meeting discussions and two e-surveys on vitiligo repigmentation, which had been carried out over 3 yr. Treatment is defined as successful if repigmentation exceeds 80% and at least 80% of the gained repigmentation is maintained for over 6 months. No agreement was found on the best outcome measure for assessing target or global repigmentation, therefore highlighting the limitations of e-surveys in addressing clinical measurements. Until there is a clear consensus, existing tools should be selected according to the specific needs of each study. A workshop will be conducted to address the remaining issues so as to achieve a consensus.

DOI: 10.1111/pcmr.12561
PubMed: 27864868


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pubmed:27864868

Le document en format XML

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</author>
<author>
<name sortKey="Eleftheriadou, Viktoria" sort="Eleftheriadou, Viktoria" uniqKey="Eleftheriadou V" first="Viktoria" last="Eleftheriadou">Viktoria Eleftheriadou</name>
<affiliation wicri:level="4">
<nlm:affiliation>Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre of Evidence Based Dermatology, University of Nottingham, Nottingham</wicri:regionArea>
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<settlement type="city">Nottingham</settlement>
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<author>
<name sortKey="Esmat, Samia" sort="Esmat, Samia" uniqKey="Esmat S" first="Samia" last="Esmat">Samia Esmat</name>
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<nlm:affiliation>Dermatology Department, Cairo University, Cairo, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Dermatology Department, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hamzavi, Iltefat" sort="Hamzavi, Iltefat" uniqKey="Hamzavi I" first="Iltefat" last="Hamzavi">Iltefat Hamzavi</name>
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<nlm:affiliation>Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MI</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Passeron, Thierry" sort="Passeron, Thierry" uniqKey="Passeron T" first="Thierry" last="Passeron">Thierry Passeron</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Dermatology, University Hospital of Nice, Nice, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, University Hospital of Nice, Nice</wicri:regionArea>
<placeName>
<region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
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</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bohm, Markus" sort="Bohm, Markus" uniqKey="Bohm M" first="Markus" last="Böhm">Markus Böhm</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Dermatology, University of Münster, Münster, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology, University of Münster, Münster</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Anbar, Tag" sort="Anbar, Tag" uniqKey="Anbar T" first="Tag" last="Anbar">Tag Anbar</name>
<affiliation wicri:level="1">
<nlm:affiliation>Dermatology Department, Minia University, Minia, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Dermatology Department, Minia University, Minia</wicri:regionArea>
<wicri:noRegion>Minia</wicri:noRegion>
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</author>
<author>
<name sortKey="Goh, Boon Kee" sort="Goh, Boon Kee" uniqKey="Goh B" first="Boon Kee" last="Goh">Boon Kee Goh</name>
<affiliation wicri:level="1">
<nlm:affiliation>Skin Physicians, Mount Elizabeth Medical Center, Singapore City, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Skin Physicians, Mount Elizabeth Medical Center, Singapore City</wicri:regionArea>
<wicri:noRegion>Singapore City</wicri:noRegion>
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</author>
<author>
<name sortKey="Lan, Cheng Che E" sort="Lan, Cheng Che E" uniqKey="Lan C" first="Cheng-Che E" last="Lan">Cheng-Che E. Lan</name>
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<nlm:affiliation>Department of Dermatology, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Dermatology, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lui, Harvey" sort="Lui, Harvey" uniqKey="Lui H" first="Harvey" last="Lui">Harvey Lui</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ramam, M" sort="Ramam, M" uniqKey="Ramam M" first="M" last="Ramam">M. Ramam</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi</wicri:regionArea>
<wicri:noRegion>New Delhi</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Raboobee, Noufal" sort="Raboobee, Noufal" uniqKey="Raboobee N" first="Noufal" last="Raboobee">Noufal Raboobee</name>
<affiliation wicri:level="1">
<nlm:affiliation>Suite 202, Westville Hospital, Westville, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Suite 202, Westville Hospital, Westville</wicri:regionArea>
<wicri:noRegion>Westville</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Katayama, Ichiro" sort="Katayama, Ichiro" uniqKey="Katayama I" first="Ichiro" last="Katayama">Ichiro Katayama</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Dermatology Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Suzuki, Tamio" sort="Suzuki, Tamio" uniqKey="Suzuki T" first="Tamio" last="Suzuki">Tamio Suzuki</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology, Faculty of Medicine, Yamagata University, Yamagata, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Dermatology, Faculty of Medicine, Yamagata University, Yamagata</wicri:regionArea>
<wicri:noRegion>Yamagata</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Parsad, Davinder" sort="Parsad, Davinder" uniqKey="Parsad D" first="Davinder" last="Parsad">Davinder Parsad</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Dermatology, Postgraduate Institute of Medical Education & Research, Chandigarh</wicri:regionArea>
<wicri:noRegion>Chandigarh</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Seth, Vaneeta" sort="Seth, Vaneeta" uniqKey="Seth V" first="Vaneeta" last="Seth">Vaneeta Seth</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Dermatology, Newton Wellesley Hospital, Newton, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, Newton Wellesley Hospital, Newton, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lim, Henry W" sort="Lim, Henry W" uniqKey="Lim H" first="Henry W" last="Lim">Henry W. Lim</name>
<affiliation wicri:level="2">
<nlm:affiliation>Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MI</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Geel, Nanja" sort="Van Geel, Nanja" uniqKey="Van Geel N" first="Nanja" last="Van Geel">Nanja Van Geel</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Dermatology, Ghent University Hospital, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mulekar, Sanjeev" sort="Mulekar, Sanjeev" uniqKey="Mulekar S" first="Sanjeev" last="Mulekar">Sanjeev Mulekar</name>
<affiliation wicri:level="1">
<nlm:affiliation>National Center for Vitiligo and Psoriasis, Riyadh, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>National Center for Vitiligo and Psoriasis, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Harris, John" sort="Harris, John" uniqKey="Harris J" first="John" last="Harris">John Harris</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA</wicri:regionArea>
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<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wittal, Richard" sort="Wittal, Richard" uniqKey="Wittal R" first="Richard" last="Wittal">Richard Wittal</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Dermatology, University of New South Wales, Sydney, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Benzekri, Laila" sort="Benzekri, Laila" uniqKey="Benzekri L" first="Laila" last="Benzekri">Laila Benzekri</name>
<affiliation wicri:level="3">
<nlm:affiliation>Mohammed V University in Rabat, Department of Dermatology, Ibn Sina University Hospital, Rabat, Morocco.</nlm:affiliation>
<country xml:lang="fr">Maroc</country>
<wicri:regionArea>Mohammed V University in Rabat, Department of Dermatology, Ibn Sina University Hospital, Rabat</wicri:regionArea>
<placeName>
<settlement type="city">Rabat</settlement>
<region nuts="2">Rabat-Salé-Kénitra</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gauthier, Yvon" sort="Gauthier, Yvon" uniqKey="Gauthier Y" first="Yvon" last="Gauthier">Yvon Gauthier</name>
<affiliation wicri:level="3">
<nlm:affiliation>Pigmentary Disorders Outpatient Clinic, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Pigmentary Disorders Outpatient Clinic, Bordeaux</wicri:regionArea>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kumarasinghe, Prasad" sort="Kumarasinghe, Prasad" uniqKey="Kumarasinghe P" first="Prasad" last="Kumarasinghe">Prasad Kumarasinghe</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology, Fiona Stanley Hospital and University of Western Australia, Perth, WA, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Dermatology, Fiona Stanley Hospital and University of Western Australia, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Thng, Steven T G" sort="Thng, Steven T G" uniqKey="Thng S" first="Steven T G" last="Thng">Steven T G. Thng</name>
<affiliation wicri:level="1">
<nlm:affiliation>National Skin Centre, Singapore City, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>National Skin Centre, Singapore City</wicri:regionArea>
<wicri:noRegion>Singapore City</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Silva De Castro, Caio Cesar" sort="Silva De Castro, Caio Cesar" uniqKey="Silva De Castro C" first="Caio Cesar" last="Silva De Castro">Caio Cesar Silva De Castro</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Dermatology, Pontifícia Universidade Católica do Paraná, Curitiba</wicri:regionArea>
<wicri:noRegion>Curitiba</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Abdallah, Marwa" sort="Abdallah, Marwa" uniqKey="Abdallah M" first="Marwa" last="Abdallah">Marwa Abdallah</name>
<affiliation wicri:level="1">
<nlm:affiliation>Dermatology, Andrology & Venereology Department, Ain Shams University, Cairo, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Dermatology, Andrology & Venereology Department, Ain Shams University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
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</author>
<author>
<name sortKey="Vrijman, Charlotte" sort="Vrijman, Charlotte" uniqKey="Vrijman C" first="Charlotte" last="Vrijman">Charlotte Vrijman</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Dermatology, Academic Medical Centre, Netherlands Institute for Pigment Disorders, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Dermatology, Academic Medical Centre, Netherlands Institute for Pigment Disorders, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
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<author>
<name sortKey="Bekkenk, Marcel" sort="Bekkenk, Marcel" uniqKey="Bekkenk M" first="Marcel" last="Bekkenk">Marcel Bekkenk</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Dermatology, Academic Medical Centre, Netherlands Institute for Pigment Disorders, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Dermatology, Academic Medical Centre, Netherlands Institute for Pigment Disorders, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
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</author>
<author>
<name sortKey="Seneschal, Julien" sort="Seneschal, Julien" uniqKey="Seneschal J" first="Julien" last="Seneschal">Julien Seneschal</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Dermatology and Pediatric Dermatology, Bordeaux University Hospitals, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology and Pediatric Dermatology, Bordeaux University Hospitals, Bordeaux</wicri:regionArea>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pandya, Amit G" sort="Pandya, Amit G" uniqKey="Pandya A" first="Amit G" last="Pandya">Amit G. Pandya</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ezzedine, Khaled" sort="Ezzedine, Khaled" uniqKey="Ezzedine K" first="Khaled" last="Ezzedine">Khaled Ezzedine</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Dermatology, Hôpital Henri Mondor, Créteil, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Hôpital Henri Mondor, Créteil</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
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</author>
<author>
<name sortKey="Picardo, Mauro" sort="Picardo, Mauro" uniqKey="Picardo M" first="Mauro" last="Picardo">Mauro Picardo</name>
<affiliation wicri:level="3">
<nlm:affiliation>Cutaneous pathophysiology, San Gallicano Dermatologic Institute IRCCS, Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Cutaneous pathophysiology, San Gallicano Dermatologic Institute IRCCS, Rome</wicri:regionArea>
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<settlement type="city">Rome</settlement>
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<name sortKey="Taieb, Alain" sort="Taieb, Alain" uniqKey="Taieb A" first="Alain" last="Taïeb">Alain Taïeb</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Dermatology and Pediatric Dermatology, Bordeaux University Hospitals, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology and Pediatric Dermatology, Bordeaux University Hospitals, Bordeaux</wicri:regionArea>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
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<title level="j">Pigment cell & melanoma research</title>
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<div type="abstract" xml:lang="en">The Vitiligo Global Issues Consensus Conference (VGICC), through an international e-Delphi consensus, concluded that 'repigmentation' and 'maintenance of gained repigmentation' are essential core outcome measures in future vitiligo trials. This VGICC position paper addresses these core topics in two sections and includes an atlas depicting vitiligo repigmentation patterns and color match. The first section delineates mechanisms and characteristics of vitiligo repigmentation, and the second section summarizes the outcomes of international meeting discussions and two e-surveys on vitiligo repigmentation, which had been carried out over 3 yr. Treatment is defined as successful if repigmentation exceeds 80% and at least 80% of the gained repigmentation is maintained for over 6 months. No agreement was found on the best outcome measure for assessing target or global repigmentation, therefore highlighting the limitations of e-surveys in addressing clinical measurements. Until there is a clear consensus, existing tools should be selected according to the specific needs of each study. A workshop will be conducted to address the remaining issues so as to achieve a consensus.</div>
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<Year>2016</Year>
<Month>11</Month>
<Day>19</Day>
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<Issue>1</Issue>
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<Title>Pigment cell & melanoma research</Title>
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<ArticleTitle>Repigmentation in vitiligo: position paper of the Vitiligo Global Issues Consensus Conference.</ArticleTitle>
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<MedlinePgn>28-40</MedlinePgn>
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<AbstractText>The Vitiligo Global Issues Consensus Conference (VGICC), through an international e-Delphi consensus, concluded that 'repigmentation' and 'maintenance of gained repigmentation' are essential core outcome measures in future vitiligo trials. This VGICC position paper addresses these core topics in two sections and includes an atlas depicting vitiligo repigmentation patterns and color match. The first section delineates mechanisms and characteristics of vitiligo repigmentation, and the second section summarizes the outcomes of international meeting discussions and two e-surveys on vitiligo repigmentation, which had been carried out over 3 yr. Treatment is defined as successful if repigmentation exceeds 80% and at least 80% of the gained repigmentation is maintained for over 6 months. No agreement was found on the best outcome measure for assessing target or global repigmentation, therefore highlighting the limitations of e-surveys in addressing clinical measurements. Until there is a clear consensus, existing tools should be selected according to the specific needs of each study. A workshop will be conducted to address the remaining issues so as to achieve a consensus.</AbstractText>
<CopyrightInformation>© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation>
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<LastName>Gan</LastName>
<ForeName>Emily Y</ForeName>
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<Affiliation>National Skin Centre, Singapore City, Singapore.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Eleftheriadou</LastName>
<ForeName>Viktoria</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.</Affiliation>
</AffiliationInfo>
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<LastName>Esmat</LastName>
<ForeName>Samia</ForeName>
<Initials>S</Initials>
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<Affiliation>Dermatology Department, Cairo University, Cairo, Egypt.</Affiliation>
</AffiliationInfo>
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<LastName>Hamzavi</LastName>
<ForeName>Iltefat</ForeName>
<Initials>I</Initials>
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<Affiliation>Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.</Affiliation>
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<LastName>Passeron</LastName>
<ForeName>Thierry</ForeName>
<Initials>T</Initials>
<AffiliationInfo>
<Affiliation>Department of Dermatology, University Hospital of Nice, Nice, France.</Affiliation>
</AffiliationInfo>
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