Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: A pilot trial in four villages of Eastern Myanmar.
Identifieur interne : 000391 ( PubMed/Checkpoint ); précédent : 000390; suivant : 000392Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: A pilot trial in four villages of Eastern Myanmar.
Auteurs : Jordi Landier [Thaïlande] ; Ladda Kajeechiwa [Thaïlande] ; May Myo Thwin [Thaïlande] ; Daniel M. Parker [Thaïlande] ; Victor Chaumeau [Thaïlande] ; Jacher Wiladphaingern [Thaïlande] ; Mallika Imwong [Thaïlande] ; Olivo Miotto [Thaïlande] ; Krittaya Patumrat [Thaïlande] ; Jureeporn Duanguppama [Thaïlande] ; Dominique Cerqueira [Thaïlande] ; Benoit Malleret [Singapour] ; Laurent Rénia [Singapour] ; Suphak Nosten [Thaïlande] ; Lorenz Von Seidlein [Thaïlande] ; Clare Ling [Thaïlande] ; Stéphane Proux [Thaïlande] ; Vincent Corbel [France] ; Julie A. Simpson [Australie] ; Arjen M. Dondorp [Thaïlande] ; Nicholas J. White [Thaïlande] ; François H. Nosten [Thaïlande]Source :
- Wellcome open research [ 2398-502X ] ; 2017.
Abstract
Background: Artemisinin and partner drug-resistant falciparum malaria is expanding over the Greater Mekong Sub-region (GMS). Eliminating falciparum malaria in the GMS while drugs still retain enough efficacy could prevent global spread of antimalarial resistance. Eliminating malaria rapidly requires targeting the reservoir of asymptomatic parasite carriers. This pilot trial aimed to evaluate the acceptability, safety, feasibility and effectiveness of mass-drug administration (MDA) in reducing malaria in four villages in Eastern Myanmar. Methods: Villages with ≥30% malaria prevalence were selected. Long-lasting insecticidal bednets (LLINs) and access to malaria early diagnosis and treatment (EDT) were provided. Two villages received MDA immediately and two were followed for nine months pre-MDA. MDA consisted of a 3-day supervised course of dihydroartemisinin-piperaquine and single low-dose primaquine administered monthly for three months. Adverse events (AE) were monitored by interviews and consultations. Malaria prevalence was assessed by ultrasensitive PCR quarterly for 24 months. Symptomatic malaria incidence,entomological indices, and antimalarial resistance markers were monitored. Results: MDA was well tolerated. There were no serious AE and mild to moderate AE were reported in 5.6%(212/3931) interviews. In the smaller villages, participation to three MDA courses was 61% and 57%, compared to 28% and 29% in the larger villages. Baseline prevalence was higher in intervention than in control villages (18.7% (95%CI=16.1-21.6) versus 6.8%(5.2-8.7), p<0.0001) whereas three months after starting MDA, prevalence was lower in intervention villages (0.4%(0.04-1.3) versus 2.7%(1.7-4.1), p=0.0014). After nine months the difference was no longer significant (2.0%(1.0-3.5) versus 0.9%(0.04-1.8), p=0.10). M0-M9 symptomatic falciparum incidence was similar between intervention and control. Before/after MDA comparisons showed that asymptomatic P. falciparum carriage and anopheline vector positivity decreased significantly whereas prevalence of the artemisinin-resistance molecular marker remained stable. Conclusions: This MDA was safe and feasible, and, could accelerate elimination of P. falciparum in addition to EDT and LLINs when community participation was sufficient.
DOI: 10.12688/wellcomeopenres.12240.1
PubMed: 29062913
Affiliations:
- Australie, France, Singapour, Thaïlande
- Languedoc-Roussillon, Occitanie (région administrative), Victoria (État)
- Melbourne, Montpellier
- Université de Melbourne, Université nationale de Singapour
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Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Corbel, Vincent" sort="Corbel, Vincent" uniqKey="Corbel V" first="Vincent" last="Corbel">Vincent Corbel</name><affiliation wicri:level="3"><nlm:affiliation>Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle (IRD 224-CNRS 4280 UM1-UM2), Institut de Recherche pour le Développement, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle (IRD 224-CNRS 4280 UM1-UM2), Institut de Recherche pour le Développement, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Simpson, Julie A" sort="Simpson, Julie A" uniqKey="Simpson J" first="Julie A" last="Simpson">Julie A. Simpson</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3053, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3053</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dondorp, Arjen M" sort="Dondorp, Arjen M" uniqKey="Dondorp A" first="Arjen M" last="Dondorp">Arjen M. 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White</name><affiliation wicri:level="1"><nlm:affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Nosten, Francois H" sort="Nosten, Francois H" uniqKey="Nosten F" first="François H" last="Nosten">François H. Nosten</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29062913</idno><idno type="pmid">29062913</idno><idno type="doi">10.12688/wellcomeopenres.12240.1</idno><idno type="wicri:Area/PubMed/Corpus">000563</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000563</idno><idno type="wicri:Area/PubMed/Curation">000561</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000561</idno><idno type="wicri:Area/PubMed/Checkpoint">000561</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000561</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: A pilot trial in four villages of Eastern Myanmar.</title><author><name sortKey="Landier, Jordi" sort="Landier, Jordi" uniqKey="Landier J" first="Jordi" last="Landier">Jordi Landier</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Kajeechiwa, Ladda" sort="Kajeechiwa, Ladda" uniqKey="Kajeechiwa L" first="Ladda" last="Kajeechiwa">Ladda Kajeechiwa</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Thwin, May Myo" sort="Thwin, May Myo" uniqKey="Thwin M" first="May Myo" last="Thwin">May Myo Thwin</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Parker, Daniel M" sort="Parker, Daniel M" uniqKey="Parker D" first="Daniel M" last="Parker">Daniel M. Parker</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Chaumeau, Victor" sort="Chaumeau, Victor" uniqKey="Chaumeau V" first="Victor" last="Chaumeau">Victor Chaumeau</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Wiladphaingern, Jacher" sort="Wiladphaingern, Jacher" uniqKey="Wiladphaingern J" first="Jacher" last="Wiladphaingern">Jacher Wiladphaingern</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Imwong, Mallika" sort="Imwong, Mallika" uniqKey="Imwong M" first="Mallika" last="Imwong">Mallika Imwong</name><affiliation wicri:level="1"><nlm:affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Miotto, Olivo" sort="Miotto, Olivo" uniqKey="Miotto O" first="Olivo" last="Miotto">Olivo Miotto</name><affiliation wicri:level="1"><nlm:affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Patumrat, Krittaya" sort="Patumrat, Krittaya" uniqKey="Patumrat K" first="Krittaya" last="Patumrat">Krittaya Patumrat</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Duanguppama, Jureeporn" sort="Duanguppama, Jureeporn" uniqKey="Duanguppama J" first="Jureeporn" last="Duanguppama">Jureeporn Duanguppama</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Cerqueira, Dominique" sort="Cerqueira, Dominique" uniqKey="Cerqueira D" first="Dominique" last="Cerqueira">Dominique Cerqueira</name><affiliation wicri:level="1"><nlm:affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Malleret, Benoit" sort="Malleret, Benoit" uniqKey="Malleret B" first="Benoit" last="Malleret">Benoit Malleret</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Rénia">Laurent Rénia</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Immunology Network (SIgN), Agency for Science & Technology, Singapore, 138632, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Immunology Network (SIgN), Agency for Science & Technology, Singapore, 138632</wicri:regionArea><wicri:noRegion>138632</wicri:noRegion></affiliation></author><author><name sortKey="Nosten, Suphak" sort="Nosten, Suphak" uniqKey="Nosten S" first="Suphak" last="Nosten">Suphak Nosten</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Von Seidlein, Lorenz" sort="Von Seidlein, Lorenz" uniqKey="Von Seidlein L" first="Lorenz" last="Von Seidlein">Lorenz Von Seidlein</name><affiliation wicri:level="1"><nlm:affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Ling, Clare" sort="Ling, Clare" uniqKey="Ling C" first="Clare" last="Ling">Clare Ling</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Proux, Stephane" sort="Proux, Stephane" uniqKey="Proux S" first="Stéphane" last="Proux">Stéphane Proux</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author><author><name sortKey="Corbel, Vincent" sort="Corbel, Vincent" uniqKey="Corbel V" first="Vincent" last="Corbel">Vincent Corbel</name><affiliation wicri:level="3"><nlm:affiliation>Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle (IRD 224-CNRS 4280 UM1-UM2), Institut de Recherche pour le Développement, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle (IRD 224-CNRS 4280 UM1-UM2), Institut de Recherche pour le Développement, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Simpson, Julie A" sort="Simpson, Julie A" uniqKey="Simpson J" first="Julie A" last="Simpson">Julie A. Simpson</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3053, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3053</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dondorp, Arjen M" sort="Dondorp, Arjen M" uniqKey="Dondorp A" first="Arjen M" last="Dondorp">Arjen M. Dondorp</name><affiliation wicri:level="1"><nlm:affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="White, Nicholas J" sort="White, Nicholas J" uniqKey="White N" first="Nicholas J" last="White">Nicholas J. White</name><affiliation wicri:level="1"><nlm:affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Nosten, Francois H" sort="Nosten, Francois H" uniqKey="Nosten F" first="François H" last="Nosten">François H. Nosten</name><affiliation wicri:level="1"><nlm:affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot</wicri:regionArea><wicri:noRegion>Mae Sot</wicri:noRegion></affiliation></author></analytic><series><title level="j">Wellcome open research</title><idno type="ISSN">2398-502X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Artemisinin and partner drug-resistant falciparum malaria is expanding over the Greater Mekong Sub-region (GMS). Eliminating falciparum malaria in the GMS while drugs still retain enough efficacy could prevent global spread of antimalarial resistance. Eliminating malaria rapidly requires targeting the reservoir of asymptomatic parasite carriers. This pilot trial aimed to evaluate the acceptability, safety, feasibility and effectiveness of mass-drug administration (MDA) in reducing malaria in four villages in Eastern Myanmar. Methods: Villages with ≥30% malaria prevalence were selected. Long-lasting insecticidal bednets (LLINs) and access to malaria early diagnosis and treatment (EDT) were provided. Two villages received MDA immediately and two were followed for nine months pre-MDA. MDA consisted of a 3-day supervised course of dihydroartemisinin-piperaquine and single low-dose primaquine administered monthly for three months. Adverse events (AE) were monitored by interviews and consultations. Malaria prevalence was assessed by ultrasensitive PCR quarterly for 24 months. Symptomatic malaria incidence,entomological indices, and antimalarial resistance markers were monitored. Results: MDA was well tolerated. There were no serious AE and mild to moderate AE were reported in 5.6%(212/3931) interviews. In the smaller villages, participation to three MDA courses was 61% and 57%, compared to 28% and 29% in the larger villages. Baseline prevalence was higher in intervention than in control villages (18.7% (95%CI=16.1-21.6) versus 6.8%(5.2-8.7), p<0.0001) whereas three months after starting MDA, prevalence was lower in intervention villages (0.4%(0.04-1.3) versus 2.7%(1.7-4.1), p=0.0014). After nine months the difference was no longer significant (2.0%(1.0-3.5) versus 0.9%(0.04-1.8), p=0.10). M0-M9 symptomatic falciparum incidence was similar between intervention and control. Before/after MDA comparisons showed that asymptomatic P. falciparum carriage and anopheline vector positivity decreased significantly whereas prevalence of the artemisinin-resistance molecular marker remained stable. Conclusions: This MDA was safe and feasible, and, could accelerate elimination of P. falciparum in addition to EDT and LLINs when community participation was sufficient.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">29062913</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>24</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>27</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2398-502X</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Wellcome open research</Title><ISOAbbreviation>Wellcome Open Res</ISOAbbreviation></Journal><ArticleTitle>Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: A pilot trial in four villages of Eastern Myanmar.</ArticleTitle><Pagination><MedlinePgn>81</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.12688/wellcomeopenres.12240.1</ELocationID><Abstract><AbstractText>Background: Artemisinin and partner drug-resistant falciparum malaria is expanding over the Greater Mekong Sub-region (GMS). Eliminating falciparum malaria in the GMS while drugs still retain enough efficacy could prevent global spread of antimalarial resistance. Eliminating malaria rapidly requires targeting the reservoir of asymptomatic parasite carriers. This pilot trial aimed to evaluate the acceptability, safety, feasibility and effectiveness of mass-drug administration (MDA) in reducing malaria in four villages in Eastern Myanmar. Methods: Villages with ≥30% malaria prevalence were selected. Long-lasting insecticidal bednets (LLINs) and access to malaria early diagnosis and treatment (EDT) were provided. Two villages received MDA immediately and two were followed for nine months pre-MDA. MDA consisted of a 3-day supervised course of dihydroartemisinin-piperaquine and single low-dose primaquine administered monthly for three months. Adverse events (AE) were monitored by interviews and consultations. Malaria prevalence was assessed by ultrasensitive PCR quarterly for 24 months. Symptomatic malaria incidence,entomological indices, and antimalarial resistance markers were monitored. Results: MDA was well tolerated. There were no serious AE and mild to moderate AE were reported in 5.6%(212/3931) interviews. In the smaller villages, participation to three MDA courses was 61% and 57%, compared to 28% and 29% in the larger villages. Baseline prevalence was higher in intervention than in control villages (18.7% (95%CI=16.1-21.6) versus 6.8%(5.2-8.7), p<0.0001) whereas three months after starting MDA, prevalence was lower in intervention villages (0.4%(0.04-1.3) versus 2.7%(1.7-4.1), p=0.0014). After nine months the difference was no longer significant (2.0%(1.0-3.5) versus 0.9%(0.04-1.8), p=0.10). M0-M9 symptomatic falciparum incidence was similar between intervention and control. Before/after MDA comparisons showed that asymptomatic P. falciparum carriage and anopheline vector positivity decreased significantly whereas prevalence of the artemisinin-resistance molecular marker remained stable. Conclusions: This MDA was safe and feasible, and, could accelerate elimination of P. falciparum in addition to EDT and LLINs when community participation was sufficient.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Landier</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8619-9775</Identifier><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kajeechiwa</LastName><ForeName>Ladda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thwin</LastName><ForeName>May Myo</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parker</LastName><ForeName>Daniel M</ForeName><Initials>DM</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-5352-7338</Identifier><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaumeau</LastName><ForeName>Victor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle (IRD 224-CNRS 4280 UM1-UM2), Institut de Recherche pour le Développement, Montpellier, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre Hospitalier Régional Universitaire de Montpellier, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiladphaingern</LastName><ForeName>Jacher</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Imwong</LastName><ForeName>Mallika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miotto</LastName><ForeName>Olivo</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Genomics and Global Health, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patumrat</LastName><ForeName>Krittaya</ForeName><Initials>K</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-6585-9997</Identifier><AffiliationInfo><Affiliation>Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duanguppama</LastName><ForeName>Jureeporn</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerqueira</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malleret</LastName><ForeName>Benoit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Singapore Immunology Network (SIgN), Agency for Science & Technology, Singapore, 138632, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rénia</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Singapore Immunology Network (SIgN), Agency for Science & Technology, Singapore, 138632, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nosten</LastName><ForeName>Suphak</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Seidlein</LastName><ForeName>Lorenz</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ling</LastName><ForeName>Clare</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Proux</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4201-5473</Identifier><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corbel</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle (IRD 224-CNRS 4280 UM1-UM2), Institut de Recherche pour le Développement, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Julie A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3053, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dondorp</LastName><ForeName>Arjen M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nosten</LastName><ForeName>François H</ForeName><Initials>FH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-7951-0745</Identifier><AffiliationInfo><Affiliation>Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>09</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Wellcome Open Res</MedlineTA><NlmUniqueID>101696457</NlmUniqueID><ISSNLinking>2398-502X</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Malar J. 2015 Aug 16;14:319</RefSource><PMID Version="1">26275909</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2014 Jul 31;371(5):411-23</RefSource><PMID Version="1">25075834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2006 Jun;3(6):e183</RefSource><PMID Version="1">16719547</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2015 May 1;211(9):1476-83</RefSource><PMID 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disclosed.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>08</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29062913</ArticleId><ArticleId IdType="doi">10.12688/wellcomeopenres.12240.1</ArticleId><ArticleId IdType="pmc">PMC5635445</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Singapour</li><li>Thaïlande</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Victoria (État)</li></region><settlement><li>Melbourne</li><li>Montpellier</li></settlement><orgName><li>Université de Melbourne</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="Thaïlande"><noRegion><name sortKey="Landier, Jordi" sort="Landier, Jordi" uniqKey="Landier J" first="Jordi" last="Landier">Jordi Landier</name></noRegion><name sortKey="Cerqueira, Dominique" sort="Cerqueira, Dominique" uniqKey="Cerqueira D" first="Dominique" last="Cerqueira">Dominique Cerqueira</name><name sortKey="Chaumeau, Victor" sort="Chaumeau, Victor" uniqKey="Chaumeau V" first="Victor" last="Chaumeau">Victor Chaumeau</name><name sortKey="Dondorp, Arjen M" sort="Dondorp, Arjen M" uniqKey="Dondorp A" first="Arjen M" last="Dondorp">Arjen M. Dondorp</name><name sortKey="Duanguppama, Jureeporn" sort="Duanguppama, Jureeporn" uniqKey="Duanguppama J" first="Jureeporn" last="Duanguppama">Jureeporn Duanguppama</name><name sortKey="Imwong, Mallika" sort="Imwong, Mallika" uniqKey="Imwong M" first="Mallika" last="Imwong">Mallika Imwong</name><name sortKey="Kajeechiwa, Ladda" sort="Kajeechiwa, Ladda" uniqKey="Kajeechiwa L" first="Ladda" last="Kajeechiwa">Ladda Kajeechiwa</name><name sortKey="Ling, Clare" sort="Ling, Clare" uniqKey="Ling C" first="Clare" last="Ling">Clare Ling</name><name sortKey="Miotto, Olivo" sort="Miotto, Olivo" uniqKey="Miotto O" first="Olivo" last="Miotto">Olivo Miotto</name><name sortKey="Nosten, Francois H" sort="Nosten, Francois H" uniqKey="Nosten F" first="François H" last="Nosten">François H. Nosten</name><name sortKey="Nosten, Suphak" sort="Nosten, Suphak" uniqKey="Nosten S" first="Suphak" last="Nosten">Suphak Nosten</name><name sortKey="Parker, Daniel M" sort="Parker, Daniel M" uniqKey="Parker D" first="Daniel M" last="Parker">Daniel M. Parker</name><name sortKey="Patumrat, Krittaya" sort="Patumrat, Krittaya" uniqKey="Patumrat K" first="Krittaya" last="Patumrat">Krittaya Patumrat</name><name sortKey="Proux, Stephane" sort="Proux, Stephane" uniqKey="Proux S" first="Stéphane" last="Proux">Stéphane Proux</name><name sortKey="Thwin, May Myo" sort="Thwin, May Myo" uniqKey="Thwin M" first="May Myo" last="Thwin">May Myo Thwin</name><name sortKey="Von Seidlein, Lorenz" sort="Von Seidlein, Lorenz" uniqKey="Von Seidlein L" first="Lorenz" last="Von Seidlein">Lorenz Von Seidlein</name><name sortKey="White, Nicholas J" sort="White, Nicholas J" uniqKey="White N" first="Nicholas J" last="White">Nicholas J. White</name><name sortKey="Wiladphaingern, Jacher" sort="Wiladphaingern, Jacher" uniqKey="Wiladphaingern J" first="Jacher" last="Wiladphaingern">Jacher Wiladphaingern</name></country><country name="Singapour"><noRegion><name sortKey="Malleret, Benoit" sort="Malleret, Benoit" uniqKey="Malleret B" first="Benoit" last="Malleret">Benoit Malleret</name></noRegion><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Rénia">Laurent Rénia</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Corbel, Vincent" sort="Corbel, Vincent" uniqKey="Corbel V" first="Vincent" last="Corbel">Vincent Corbel</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Simpson, Julie A" sort="Simpson, Julie A" uniqKey="Simpson J" first="Julie A" last="Simpson">Julie A. Simpson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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