THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
Identifieur interne : 000293 ( PubMed/Checkpoint ); précédent : 000292; suivant : 000294THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
Auteurs : Stephen Ph Alexander [Royaume-Uni] ; Eamonn Kelly [Royaume-Uni] ; Neil V. Marrion [Royaume-Uni] ; John A. Peters [Royaume-Uni] ; Elena Faccenda [Royaume-Uni] ; Simon D. Harding [Royaume-Uni] ; Adam J. Pawson [Royaume-Uni] ; Joanna L. Sharman [Royaume-Uni] ; Christopher Southan [Royaume-Uni] ; O Peter Buneman [Royaume-Uni] ; John A. Cidlowski [États-Unis] ; Arthur Christopoulos [Australie] ; Anthony P. Davenport [Royaume-Uni] ; Doriano Fabbro [Suisse] ; Michael Spedding [France] ; Jörg Striessnig [Autriche] ; Jamie A. Davies [Royaume-Uni]Source :
- British journal of pharmacology [ 1476-5381 ] ; 2017.
Abstract
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
DOI: 10.1111/bph.13882
PubMed: 29055037
Affiliations:
- Australie, Autriche, France, Royaume-Uni, Suisse, États-Unis
- Angleterre, Angleterre de l'Est, Caroline du Nord, Écosse
- Cambridge, Édimbourg
- Université d'Édimbourg, Université de Cambridge
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:29055037Le document en format XML
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Marrion</name><affiliation wicri:level="1"><nlm:affiliation>School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD</wicri:regionArea><wicri:noRegion>BS8 1TD</wicri:noRegion></affiliation></author><author><name sortKey="Peters, John A" sort="Peters, John A" uniqKey="Peters J" first="John A" last="Peters">John A. Peters</name><affiliation wicri:level="1"><nlm:affiliation>Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY</wicri:regionArea><wicri:noRegion>DD1 9SY</wicri:noRegion></affiliation></author><author><name sortKey="Faccenda, Elena" sort="Faccenda, Elena" uniqKey="Faccenda E" first="Elena" last="Faccenda">Elena Faccenda</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Harding, Simon D" sort="Harding, Simon D" uniqKey="Harding S" first="Simon D" last="Harding">Simon D. Harding</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Pawson, Adam J" sort="Pawson, Adam J" uniqKey="Pawson A" first="Adam J" last="Pawson">Adam J. Pawson</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Sharman, Joanna L" sort="Sharman, Joanna L" uniqKey="Sharman J" first="Joanna L" last="Sharman">Joanna L. Sharman</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Southan, Christopher" sort="Southan, Christopher" uniqKey="Southan C" first="Christopher" last="Southan">Christopher Southan</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Buneman, O Peter" sort="Buneman, O Peter" uniqKey="Buneman O" first="O Peter" last="Buneman">O Peter Buneman</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Cidlowski, John A" sort="Cidlowski, John A" uniqKey="Cidlowski J" first="John A" last="Cidlowski">John A. Cidlowski</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Christopoulos, Arthur" sort="Christopoulos, Arthur" uniqKey="Christopoulos A" first="Arthur" last="Christopoulos">Arthur Christopoulos</name><affiliation wicri:level="1"><nlm:affiliation>Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria 3052</wicri:regionArea><wicri:noRegion>Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Davenport, Anthony P" sort="Davenport, Anthony P" uniqKey="Davenport A" first="Anthony P" last="Davenport">Anthony P. Davenport</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Fabbro, Doriano" sort="Fabbro, Doriano" uniqKey="Fabbro D" first="Doriano" last="Fabbro">Doriano Fabbro</name><affiliation wicri:level="1"><nlm:affiliation>PIQUR Therapeutics, Basel, 4057, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>PIQUR Therapeutics, Basel, 4057</wicri:regionArea><wicri:noRegion>4057</wicri:noRegion></affiliation></author><author><name sortKey="Spedding, Michael" sort="Spedding, Michael" uniqKey="Spedding M" first="Michael" last="Spedding">Michael Spedding</name><affiliation wicri:level="1"><nlm:affiliation>Spedding Research Solutions SARL, Le Vésinet, 78110, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Spedding Research Solutions SARL, Le Vésinet, 78110</wicri:regionArea><wicri:noRegion>78110</wicri:noRegion><wicri:noRegion>78110</wicri:noRegion></affiliation></author><author><name sortKey="Striessnig, Jorg" sort="Striessnig, Jorg" uniqKey="Striessnig J" first="Jörg" last="Striessnig">Jörg Striessnig</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck</wicri:regionArea><wicri:noRegion>A-6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Jamie A" sort="Davies, Jamie A" uniqKey="Davies J" first="Jamie A" last="Davies">Jamie A. Davies</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j">British journal of pharmacology</title><idno type="eISSN">1476-5381</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">29055037</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>21</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1476-5381</ISSN><JournalIssue CitedMedium="Internet"><Volume>174 Suppl 1</Volume><PubDate><Year>2017</Year><Month>Dec</Month></PubDate></JournalIssue><Title>British journal of pharmacology</Title><ISOAbbreviation>Br. J. Pharmacol.</ISOAbbreviation></Journal><ArticleTitle>THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.</ArticleTitle><Pagination><MedlinePgn>S1-S16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/bph.13882</ELocationID><Abstract><AbstractText>The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.</AbstractText><CopyrightInformation>© 2017 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alexander</LastName><ForeName>Stephen Ph</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelly</LastName><ForeName>Eamonn</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marrion</LastName><ForeName>Neil V</ForeName><Initials>NV</Initials><AffiliationInfo><Affiliation>School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>John A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faccenda</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harding</LastName><ForeName>Simon D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pawson</LastName><ForeName>Adam J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharman</LastName><ForeName>Joanna L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Southan</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buneman</LastName><ForeName>O Peter</ForeName><Initials>OP</Initials><AffiliationInfo><Affiliation>Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cidlowski</LastName><ForeName>John A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>National 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Stephen Ph" uniqKey="Alexander S" first="Stephen Ph" last="Alexander">Stephen Ph Alexander</name></noRegion><name sortKey="Buneman, O Peter" sort="Buneman, O Peter" uniqKey="Buneman O" first="O Peter" last="Buneman">O Peter Buneman</name><name sortKey="Davenport, Anthony P" sort="Davenport, Anthony P" uniqKey="Davenport A" first="Anthony P" last="Davenport">Anthony P. Davenport</name><name sortKey="Davies, Jamie A" sort="Davies, Jamie A" uniqKey="Davies J" first="Jamie A" last="Davies">Jamie A. Davies</name><name sortKey="Faccenda, Elena" sort="Faccenda, Elena" uniqKey="Faccenda E" first="Elena" last="Faccenda">Elena Faccenda</name><name sortKey="Harding, Simon D" sort="Harding, Simon D" uniqKey="Harding S" first="Simon D" last="Harding">Simon D. Harding</name><name sortKey="Kelly, Eamonn" sort="Kelly, Eamonn" uniqKey="Kelly E" first="Eamonn" last="Kelly">Eamonn Kelly</name><name sortKey="Marrion, Neil V" sort="Marrion, Neil V" uniqKey="Marrion N" first="Neil V" last="Marrion">Neil V. Marrion</name><name sortKey="Pawson, Adam J" sort="Pawson, Adam J" uniqKey="Pawson A" first="Adam J" last="Pawson">Adam J. Pawson</name><name sortKey="Peters, John A" sort="Peters, John A" uniqKey="Peters J" first="John A" last="Peters">John A. Peters</name><name sortKey="Sharman, Joanna L" sort="Sharman, Joanna L" uniqKey="Sharman J" first="Joanna L" last="Sharman">Joanna L. Sharman</name><name sortKey="Southan, Christopher" sort="Southan, Christopher" uniqKey="Southan C" first="Christopher" last="Southan">Christopher Southan</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Cidlowski, John A" sort="Cidlowski, John A" uniqKey="Cidlowski J" first="John A" last="Cidlowski">John A. Cidlowski</name></region></country><country name="Australie"><noRegion><name sortKey="Christopoulos, Arthur" sort="Christopoulos, Arthur" uniqKey="Christopoulos A" first="Arthur" last="Christopoulos">Arthur Christopoulos</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Fabbro, Doriano" sort="Fabbro, Doriano" uniqKey="Fabbro D" first="Doriano" last="Fabbro">Doriano Fabbro</name></noRegion></country><country name="France"><noRegion><name sortKey="Spedding, Michael" sort="Spedding, Michael" uniqKey="Spedding M" first="Michael" last="Spedding">Michael Spedding</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Striessnig, Jorg" sort="Striessnig, Jorg" uniqKey="Striessnig J" first="Jörg" last="Striessnig">Jörg Striessnig</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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