TWO YEAR OUTCOMES OF "TREAT AND EXTEND" INTRAVITREAL THERAPY USING AFLIBERCEPT PREFERENTIALLY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.
Identifieur interne : 000291 ( PubMed/Checkpoint ); précédent : 000290; suivant : 000292TWO YEAR OUTCOMES OF "TREAT AND EXTEND" INTRAVITREAL THERAPY USING AFLIBERCEPT PREFERENTIALLY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.
Auteurs : Daniel Barthelmes [Australie] ; Vuong Nguyen ; Vincent Daien ; Anna Campain ; Richard Walton ; Robyn Guymer ; Nigel Morlet ; Alex P. Hunyor ; Rohan W. Essex ; Jennifer J. Arnold ; Mark C. GilliesSource :
- Retina (Philadelphia, Pa.) [ 1539-2864 ] ; 2017.
Abstract
To report 24-month outcomes of a treat and extend (T&E) regimen using aflibercept in eyes with neovascular age-related macular degeneration.
DOI: 10.1097/IAE.0000000000001496
PubMed: 28145976
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">TWO YEAR OUTCOMES OF "TREAT AND EXTEND" INTRAVITREAL THERAPY USING AFLIBERCEPT PREFERENTIALLY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.</title><author><name sortKey="Barthelmes, Daniel" sort="Barthelmes, Daniel" uniqKey="Barthelmes D" first="Daniel" last="Barthelmes">Daniel Barthelmes</name><affiliation wicri:level="1"><nlm:affiliation>*Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; †The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; ‡Montpellier University Hospital, Montpellier, France; §Department of Surgery (Ophthalmology), Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Victoria, Australia; ¶Department of Population Health, University of Western Australia, Perth, Western Australia; **Retina Associates, Chatswood, New South Wales, Australia; ††Academic Unit of Ophthalmology, Australian National University, Acton, Australian Capital Territory, Australia; and ‡‡Marsden Eye Specialists, Parramatta, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>*Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; †The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; ‡Montpellier University Hospital, Montpellier, France; §Department of Surgery (Ophthalmology), Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Victoria, Australia; ¶Department of Population Health, University of Western Australia, Perth, Western Australia; **Retina Associates, Chatswood, New South Wales, Australia; ††Academic Unit of Ophthalmology, Australian National University, Acton, Australian Capital Territory, Australia; and ‡‡Marsden Eye Specialists, Parramatta, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Vuong" sort="Nguyen, Vuong" uniqKey="Nguyen V" first="Vuong" last="Nguyen">Vuong Nguyen</name></author><author><name sortKey="Daien, Vincent" sort="Daien, Vincent" uniqKey="Daien V" first="Vincent" last="Daien">Vincent Daien</name></author><author><name sortKey="Campain, Anna" sort="Campain, Anna" uniqKey="Campain A" first="Anna" last="Campain">Anna Campain</name></author><author><name sortKey="Walton, Richard" sort="Walton, Richard" uniqKey="Walton R" first="Richard" last="Walton">Richard Walton</name></author><author><name sortKey="Guymer, Robyn" sort="Guymer, Robyn" uniqKey="Guymer R" first="Robyn" last="Guymer">Robyn Guymer</name></author><author><name sortKey="Morlet, Nigel" sort="Morlet, Nigel" uniqKey="Morlet N" first="Nigel" last="Morlet">Nigel Morlet</name></author><author><name sortKey="Hunyor, Alex P" sort="Hunyor, Alex P" uniqKey="Hunyor A" first="Alex P" last="Hunyor">Alex P. Hunyor</name></author><author><name sortKey="Essex, Rohan W" sort="Essex, Rohan W" uniqKey="Essex R" first="Rohan W" last="Essex">Rohan W. Essex</name></author><author><name sortKey="Arnold, Jennifer J" sort="Arnold, Jennifer J" uniqKey="Arnold J" first="Jennifer J" last="Arnold">Jennifer J. Arnold</name></author><author><name sortKey="Gillies, Mark C" sort="Gillies, Mark C" uniqKey="Gillies M" first="Mark C" last="Gillies">Mark C. Gillies</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28145976</idno><idno type="pmid">28145976</idno><idno type="doi">10.1097/IAE.0000000000001496</idno><idno type="wicri:Area/PubMed/Corpus">001210</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001210</idno><idno type="wicri:Area/PubMed/Curation">001199</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001199</idno><idno type="wicri:Area/PubMed/Checkpoint">001199</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001199</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">TWO YEAR OUTCOMES OF "TREAT AND EXTEND" INTRAVITREAL THERAPY USING AFLIBERCEPT PREFERENTIALLY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.</title><author><name sortKey="Barthelmes, Daniel" sort="Barthelmes, Daniel" uniqKey="Barthelmes D" first="Daniel" last="Barthelmes">Daniel Barthelmes</name><affiliation wicri:level="1"><nlm:affiliation>*Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; †The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; ‡Montpellier University Hospital, Montpellier, France; §Department of Surgery (Ophthalmology), Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Victoria, Australia; ¶Department of Population Health, University of Western Australia, Perth, Western Australia; **Retina Associates, Chatswood, New South Wales, Australia; ††Academic Unit of Ophthalmology, Australian National University, Acton, Australian Capital Territory, Australia; and ‡‡Marsden Eye Specialists, Parramatta, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>*Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; †The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; ‡Montpellier University Hospital, Montpellier, France; §Department of Surgery (Ophthalmology), Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Victoria, Australia; ¶Department of Population Health, University of Western Australia, Perth, Western Australia; **Retina Associates, Chatswood, New South Wales, Australia; ††Academic Unit of Ophthalmology, Australian National University, Acton, Australian Capital Territory, Australia; and ‡‡Marsden Eye Specialists, Parramatta, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Vuong" sort="Nguyen, Vuong" uniqKey="Nguyen V" first="Vuong" last="Nguyen">Vuong Nguyen</name></author><author><name sortKey="Daien, Vincent" sort="Daien, Vincent" uniqKey="Daien V" first="Vincent" last="Daien">Vincent Daien</name></author><author><name sortKey="Campain, Anna" sort="Campain, Anna" uniqKey="Campain A" first="Anna" last="Campain">Anna Campain</name></author><author><name sortKey="Walton, Richard" sort="Walton, Richard" uniqKey="Walton R" first="Richard" last="Walton">Richard Walton</name></author><author><name sortKey="Guymer, Robyn" sort="Guymer, Robyn" uniqKey="Guymer R" first="Robyn" last="Guymer">Robyn Guymer</name></author><author><name sortKey="Morlet, Nigel" sort="Morlet, Nigel" uniqKey="Morlet N" first="Nigel" last="Morlet">Nigel Morlet</name></author><author><name sortKey="Hunyor, Alex P" sort="Hunyor, Alex P" uniqKey="Hunyor A" first="Alex P" last="Hunyor">Alex P. Hunyor</name></author><author><name sortKey="Essex, Rohan W" sort="Essex, Rohan W" uniqKey="Essex R" first="Rohan W" last="Essex">Rohan W. Essex</name></author><author><name sortKey="Arnold, Jennifer J" sort="Arnold, Jennifer J" uniqKey="Arnold J" first="Jennifer J" last="Arnold">Jennifer J. Arnold</name></author><author><name sortKey="Gillies, Mark C" sort="Gillies, Mark C" uniqKey="Gillies M" first="Mark C" last="Gillies">Mark C. Gillies</name></author></analytic><series><title level="j">Retina (Philadelphia, Pa.)</title><idno type="eISSN">1539-2864</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To report 24-month outcomes of a treat and extend (T&E) regimen using aflibercept in eyes with neovascular age-related macular degeneration.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28145976</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>01</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1539-2864</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Jan</Month><Day>31</Day></PubDate></JournalIssue><Title>Retina (Philadelphia, Pa.)</Title><ISOAbbreviation>Retina (Philadelphia, Pa.)</ISOAbbreviation></Journal><ArticleTitle>TWO YEAR OUTCOMES OF "TREAT AND EXTEND" INTRAVITREAL THERAPY USING AFLIBERCEPT PREFERENTIALLY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1097/IAE.0000000000001496</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To report 24-month outcomes of a treat and extend (T&E) regimen using aflibercept in eyes with neovascular age-related macular degeneration.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a database observational study that included treatment-naive eyes with neovascular age-related macular degeneration tracked by the Fight Retinal Blindness! outcome registry completing 24 months of sole monotherapy with aflibercept treatment under a T&E regimen between November 1, 2012 and January 31, 2014. Locally weighted scatterplot smoothing curves were used to display visual acuity outcomes. Main outcome measures were change in visual acuity at 24 months and number of injections and visits during the study period.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The study population, identified by reviewing the database, consisted of 136 eyes from 123 patients completing 24 months of follow-up on aflibercept. Mean (SD) age was 77.2 (7.0) years, 59% were female. Mean visual acuity increased from 61.4 (∼20/60; SD 17.4) letters at baseline to 67.4 (∼20/45; SD 17.7) letters at 24 months (+6.0 letters [95% confidence interval: 3.3-8.5]; P < 0.001). From baseline to 24 months, the proportion of eyes with visual acuity ≥70 letters (20/40) increased (40%-58%, P < 0.001) and the proportion of eyes with visual acuity ≤35 letters (20/200) remained the same (10%; P = 0.547). Ninety-eight per cent of eyes starting with visual acuity ≥70 letters (20/40) were able to maintain this up to 24 months. From the first to the second year of treatment, the mean number of injections (7.8 [2.1] vs. 5.7 [2.6]; P < 0.001) and visits (8.7 [1.7] vs. 6.5 [2.4]; P < 0.001) decreased for eyes completing 24 months of treatment. When data from 60 eligible eyes that did not complete 2 years follow-up, along with 14 eyes that switched to ranibizumab, were included using last observation carried forward, the mean change in visual acuity from baseline was +5.6 letters (95% confidence interval: 3.3-7.7).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These data indicate that eyes treated with aflibercept, as a sole therapy, in routine clinical practice with a T&E regimen can achieve good visual outcomes while decreasing the burden of treatments and clinic visits.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barthelmes</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>*Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; †The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; ‡Montpellier University Hospital, Montpellier, France; §Department of Surgery (Ophthalmology), Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Victoria, Australia; ¶Department of Population Health, University of Western Australia, Perth, Western Australia; **Retina Associates, Chatswood, New South Wales, Australia; ††Academic Unit of Ophthalmology, Australian National University, Acton, Australian Capital Territory, Australia; and ‡‡Marsden Eye Specialists, Parramatta, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Vuong</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Daien</LastName><ForeName>Vincent</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Campain</LastName><ForeName>Anna</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Walton</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Guymer</LastName><ForeName>Robyn</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Morlet</LastName><ForeName>Nigel</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Hunyor</LastName><ForeName>Alex P</ForeName><Initials>AP</Initials></Author><Author ValidYN="Y"><LastName>Essex</LastName><ForeName>Rohan W</ForeName><Initials>RW</Initials></Author><Author ValidYN="Y"><LastName>Arnold</LastName><ForeName>Jennifer J</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Gillies</LastName><ForeName>Mark C</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><CollectiveName>Fight Retinal Blindness Study Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Retina</MedlineTA><NlmUniqueID>8309919</NlmUniqueID><ISSNLinking>0275-004X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28145976</ArticleId><ArticleId IdType="doi">10.1097/IAE.0000000000001496</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Arnold, Jennifer J" sort="Arnold, Jennifer J" uniqKey="Arnold J" first="Jennifer J" last="Arnold">Jennifer J. Arnold</name><name sortKey="Campain, Anna" sort="Campain, Anna" uniqKey="Campain A" first="Anna" last="Campain">Anna Campain</name><name sortKey="Daien, Vincent" sort="Daien, Vincent" uniqKey="Daien V" first="Vincent" last="Daien">Vincent Daien</name><name sortKey="Essex, Rohan W" sort="Essex, Rohan W" uniqKey="Essex R" first="Rohan W" last="Essex">Rohan W. Essex</name><name sortKey="Gillies, Mark C" sort="Gillies, Mark C" uniqKey="Gillies M" first="Mark C" last="Gillies">Mark C. Gillies</name><name sortKey="Guymer, Robyn" sort="Guymer, Robyn" uniqKey="Guymer R" first="Robyn" last="Guymer">Robyn Guymer</name><name sortKey="Hunyor, Alex P" sort="Hunyor, Alex P" uniqKey="Hunyor A" first="Alex P" last="Hunyor">Alex P. Hunyor</name><name sortKey="Morlet, Nigel" sort="Morlet, Nigel" uniqKey="Morlet N" first="Nigel" last="Morlet">Nigel Morlet</name><name sortKey="Nguyen, Vuong" sort="Nguyen, Vuong" uniqKey="Nguyen V" first="Vuong" last="Nguyen">Vuong Nguyen</name><name sortKey="Walton, Richard" sort="Walton, Richard" uniqKey="Walton R" first="Richard" last="Walton">Richard Walton</name></noCountry><country name="Australie"><noRegion><name sortKey="Barthelmes, Daniel" sort="Barthelmes, Daniel" uniqKey="Barthelmes D" first="Daniel" last="Barthelmes">Daniel Barthelmes</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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