The intensive care delirium research agenda: a multinational, interprofessional perspective.
Identifieur interne : 000183 ( PubMed/Checkpoint ); précédent : 000182; suivant : 000184The intensive care delirium research agenda: a multinational, interprofessional perspective.
Auteurs : Pratik P. Pandharipande [États-Unis] ; E Wesley Ely [États-Unis] ; Rakesh C. Arora [Canada] ; Michele C. Balas [États-Unis] ; Malaz A. Boustani [États-Unis] ; Gabriel Heras La Calle [Espagne] ; Colm Cunningham [Irlande (pays)] ; John W. Devlin [États-Unis] ; Julius Elefante [Canada] ; Jin H. Han [États-Unis] ; Alasdair M. Maclullich [Royaume-Uni] ; José R. Maldonado [États-Unis] ; Alessandro Morandi [Italie] ; Dale M. Needham [États-Unis] ; Valerie J. Page [Royaume-Uni] ; Louise Rose [Canada] ; Jorge I F. Salluh [Brésil] ; Tarek Sharshar [France] ; Yahya Shehabi [Australie] ; Yoanna Skrobik [Canada] ; Arjen J C. Slooter [Pays-Bas] ; Heidi A B. Smith [États-Unis]Source :
- Intensive care medicine [ 1432-1238 ] ; 2017.
Abstract
Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.
DOI: 10.1007/s00134-017-4860-7
PubMed: 28612089
Affiliations:
- Australie, Brésil, Canada, Espagne, France, Irlande (pays), Italie, Pays-Bas, Royaume-Uni, États-Unis
- Californie, Communauté de Madrid, Indiana, Manitoba, Maryland, Massachusetts, Ohio, Québec, Tennessee, Utrecht (province), Victoria (État), Écosse, État de Rio de Janeiro, Île-de-France
- Boston, Madrid, Melbourne, Montréal, Paris, Rio de Janeiro, Utrecht, Winnipeg, Édimbourg
- Université McGill, Université d'Édimbourg, Université du Manitoba
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Pratik.pandharipande@vanderbilt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Ely, E Wesley" sort="Ely, E Wesley" uniqKey="Ely E" first="E Wesley" last="Ely">E Wesley Ely</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary and Critical Care and Health Services Research, Vanderbilt University and VA-GRECC, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care and Health Services Research, Vanderbilt University and VA-GRECC, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Arora, Rakesh C" sort="Arora, Rakesh C" uniqKey="Arora R" first="Rakesh C" last="Arora">Rakesh C. 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Devlin</name><affiliation wicri:level="3"><nlm:affiliation>School of Pharmacy, Northeastern University, Boston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Pharmacy, Northeastern University, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Elefante, Julius" sort="Elefante, Julius" uniqKey="Elefante J" first="Julius" last="Elefante">Julius Elefante</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Han, Jin H" sort="Han, Jin H" uniqKey="Han J" first="Jin H" last="Han">Jin H. Han</name><affiliation wicri:level="2"><nlm:affiliation>Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Maclullich, Alasdair M" sort="Maclullich, Alasdair M" uniqKey="Maclullich A" first="Alasdair M" last="Maclullich">Alasdair M. Maclullich</name><affiliation wicri:level="4"><nlm:affiliation>Edinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Maldonado, Jose R" sort="Maldonado, Jose R" uniqKey="Maldonado J" first="José R" last="Maldonado">José R. Maldonado</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Morandi, Alessandro" sort="Morandi, Alessandro" uniqKey="Morandi A" first="Alessandro" last="Morandi">Alessandro Morandi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation, Ancelle Hospital, Cremona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Rehabilitation, Ancelle Hospital, Cremona</wicri:regionArea><wicri:noRegion>Cremona</wicri:noRegion></affiliation></author><author><name sortKey="Needham, Dale M" sort="Needham, Dale M" uniqKey="Needham D" first="Dale M" last="Needham">Dale M. Needham</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Page, Valerie J" sort="Page, Valerie J" uniqKey="Page V" first="Valerie J" last="Page">Valerie J. Page</name><affiliation wicri:level="1"><nlm:affiliation>Watford General Hospital, Watford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Watford General Hospital, Watford</wicri:regionArea><wicri:noRegion>Watford</wicri:noRegion></affiliation></author><author><name sortKey="Rose, Louise" sort="Rose, Louise" uniqKey="Rose L" first="Louise" last="Rose">Louise Rose</name><affiliation wicri:level="1"><nlm:affiliation>Sunnybrook Health Sciences Centre, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Sunnybrook Health Sciences Centre, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Salluh, Jorge I F" sort="Salluh, Jorge I F" uniqKey="Salluh J" first="Jorge I F" last="Salluh">Jorge I F. Salluh</name><affiliation wicri:level="3"><nlm:affiliation>Department of Critical Care, rD' OR Institute for Research and Education and Post-Graduate Program Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Critical Care, rD' OR Institute for Research and Education and Post-Graduate Program Federal University of Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Sharshar, Tarek" sort="Sharshar, Tarek" uniqKey="Sharshar T" first="Tarek" last="Sharshar">Tarek Sharshar</name><affiliation wicri:level="3"><nlm:affiliation>Department of Intensive Care Medicine, Raymond Poincaré Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Intensive Care Medicine, Raymond Poincaré Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name><affiliation wicri:level="3"><nlm:affiliation>School of Clinical Sciences, Faculty of Medicine, Monash University and Medical Center, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Clinical Sciences, Faculty of Medicine, Monash University and Medical Center, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Skrobik, Yoanna" sort="Skrobik, Yoanna" uniqKey="Skrobik Y" first="Yoanna" last="Skrobik">Yoanna Skrobik</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McGill University, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Slooter, Arjen J C" sort="Slooter, Arjen J C" uniqKey="Slooter A" first="Arjen J C" last="Slooter">Arjen J C. Slooter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Intensive Care Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Intensive Care Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Smith, Heidi A B" sort="Smith, Heidi A B" uniqKey="Smith H" first="Heidi A B" last="Smith">Heidi A B. 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Pandharipande</name><affiliation wicri:level="2"><nlm:affiliation>Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA. Pratik.pandharipande@vanderbilt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Ely, E Wesley" sort="Ely, E Wesley" uniqKey="Ely E" first="E Wesley" last="Ely">E Wesley Ely</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary and Critical Care and Health Services Research, Vanderbilt University and VA-GRECC, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care and Health Services Research, Vanderbilt University and VA-GRECC, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Arora, Rakesh C" sort="Arora, Rakesh C" uniqKey="Arora R" first="Rakesh C" last="Arora">Rakesh C. Arora</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, St. Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, St. Boniface Hospital, University of Manitoba, Winnipeg, MB</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Balas, Michele C" sort="Balas, Michele C" uniqKey="Balas M" first="Michele C" last="Balas">Michele C. Balas</name><affiliation wicri:level="2"><nlm:affiliation>Center of Excellence in Critical and Complex Care, College of Nursing, The Ohio State University, Columbus, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center of Excellence in Critical and Complex Care, College of Nursing, The Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Boustani, Malaz A" sort="Boustani, Malaz A" uniqKey="Boustani M" first="Malaz A" last="Boustani">Malaz A. Boustani</name><affiliation wicri:level="2"><nlm:affiliation>Indiana University Center for Health Innovation and Implementation Science, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Indiana University Center for Health Innovation and Implementation Science, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="La Calle, Gabriel Heras" sort="La Calle, Gabriel Heras" uniqKey="La Calle G" first="Gabriel Heras" last="La Calle">Gabriel Heras La Calle</name><affiliation wicri:level="3"><nlm:affiliation>International Research Project Humanizing Intensive Care (Proyecto HU-CI), Intensive Care Unit, Hospital Universitario de Torrejón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>International Research Project Humanizing Intensive Care (Proyecto HU-CI), Intensive Care Unit, Hospital Universitario de Torrejón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Cunningham, Colm" sort="Cunningham, Colm" uniqKey="Cunningham C" first="Colm" last="Cunningham">Colm Cunningham</name><affiliation wicri:level="1"><nlm:affiliation>School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Lloyd Institute, Trinity College Dublin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Lloyd Institute, Trinity College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Devlin, John W" sort="Devlin, John W" uniqKey="Devlin J" first="John W" last="Devlin">John W. Devlin</name><affiliation wicri:level="3"><nlm:affiliation>School of Pharmacy, Northeastern University, Boston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Pharmacy, Northeastern University, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Elefante, Julius" sort="Elefante, Julius" uniqKey="Elefante J" first="Julius" last="Elefante">Julius Elefante</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Han, Jin H" sort="Han, Jin H" uniqKey="Han J" first="Jin H" last="Han">Jin H. Han</name><affiliation wicri:level="2"><nlm:affiliation>Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Maclullich, Alasdair M" sort="Maclullich, Alasdair M" uniqKey="Maclullich A" first="Alasdair M" last="Maclullich">Alasdair M. Maclullich</name><affiliation wicri:level="4"><nlm:affiliation>Edinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Maldonado, Jose R" sort="Maldonado, Jose R" uniqKey="Maldonado J" first="José R" last="Maldonado">José R. Maldonado</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Morandi, Alessandro" sort="Morandi, Alessandro" uniqKey="Morandi A" first="Alessandro" last="Morandi">Alessandro Morandi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation, Ancelle Hospital, Cremona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Rehabilitation, Ancelle Hospital, Cremona</wicri:regionArea><wicri:noRegion>Cremona</wicri:noRegion></affiliation></author><author><name sortKey="Needham, Dale M" sort="Needham, Dale M" uniqKey="Needham D" first="Dale M" last="Needham">Dale M. Needham</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Page, Valerie J" sort="Page, Valerie J" uniqKey="Page V" first="Valerie J" last="Page">Valerie J. Page</name><affiliation wicri:level="1"><nlm:affiliation>Watford General Hospital, Watford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Watford General Hospital, Watford</wicri:regionArea><wicri:noRegion>Watford</wicri:noRegion></affiliation></author><author><name sortKey="Rose, Louise" sort="Rose, Louise" uniqKey="Rose L" first="Louise" last="Rose">Louise Rose</name><affiliation wicri:level="1"><nlm:affiliation>Sunnybrook Health Sciences Centre, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Sunnybrook Health Sciences Centre, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Salluh, Jorge I F" sort="Salluh, Jorge I F" uniqKey="Salluh J" first="Jorge I F" last="Salluh">Jorge I F. Salluh</name><affiliation wicri:level="3"><nlm:affiliation>Department of Critical Care, rD' OR Institute for Research and Education and Post-Graduate Program Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Critical Care, rD' OR Institute for Research and Education and Post-Graduate Program Federal University of Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Sharshar, Tarek" sort="Sharshar, Tarek" uniqKey="Sharshar T" first="Tarek" last="Sharshar">Tarek Sharshar</name><affiliation wicri:level="3"><nlm:affiliation>Department of Intensive Care Medicine, Raymond Poincaré Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Intensive Care Medicine, Raymond Poincaré Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name><affiliation wicri:level="3"><nlm:affiliation>School of Clinical Sciences, Faculty of Medicine, Monash University and Medical Center, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Clinical Sciences, Faculty of Medicine, Monash University and Medical Center, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Skrobik, Yoanna" sort="Skrobik, Yoanna" uniqKey="Skrobik Y" first="Yoanna" last="Skrobik">Yoanna Skrobik</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McGill University, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Slooter, Arjen J C" sort="Slooter, Arjen J C" uniqKey="Slooter A" first="Arjen J C" last="Slooter">Arjen J C. Slooter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Intensive Care Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Intensive Care Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Smith, Heidi A B" sort="Smith, Heidi A B" uniqKey="Smith H" first="Heidi A B" last="Smith">Heidi A B. Smith</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pediatric Cardiac Anesthesia, Department of Anesthesiology and Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Cardiac Anesthesia, Department of Anesthesiology and Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Intensive care medicine</title><idno type="eISSN">1432-1238</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28612089</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>14</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Jun</Month><Day>13</Day></PubDate></JournalIssue><Title>Intensive care medicine</Title><ISOAbbreviation>Intensive Care Med</ISOAbbreviation></Journal><ArticleTitle>The intensive care delirium research agenda: a multinational, interprofessional perspective.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-017-4860-7</ELocationID><Abstract><AbstractText>Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pandharipande</LastName><ForeName>Pratik P</ForeName><Initials>PP</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1389-8580</Identifier><AffiliationInfo><Affiliation>Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA. Pratik.pandharipande@vanderbilt.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ely</LastName><ForeName>E Wesley</ForeName><Initials>EW</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care and Health Services Research, Vanderbilt University and VA-GRECC, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arora</LastName><ForeName>Rakesh C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Department of Surgery, St. Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balas</LastName><ForeName>Michele C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Center of Excellence in Critical and Complex Care, College of Nursing, The Ohio State University, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boustani</LastName><ForeName>Malaz A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Indiana University Center for Health Innovation and Implementation Science, Indianapolis, IN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>La Calle</LastName><ForeName>Gabriel Heras</ForeName><Initials>GH</Initials><AffiliationInfo><Affiliation>International Research Project Humanizing Intensive Care (Proyecto HU-CI), Intensive Care Unit, Hospital Universitario de Torrejón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cunningham</LastName><ForeName>Colm</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Lloyd Institute, Trinity College Dublin, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Devlin</LastName><ForeName>John W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>School of Pharmacy, Northeastern University, Boston, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elefante</LastName><ForeName>Julius</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Jin H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>MacLullich</LastName><ForeName>Alasdair M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Edinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maldonado</LastName><ForeName>José R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morandi</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Rehabilitation, Ancelle Hospital, Cremona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Needham</LastName><ForeName>Dale M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Page</LastName><ForeName>Valerie J</ForeName><Initials>VJ</Initials><AffiliationInfo><Affiliation>Watford General Hospital, Watford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rose</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Sunnybrook Health Sciences Centre, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salluh</LastName><ForeName>Jorge I F</ForeName><Initials>JIF</Initials><AffiliationInfo><Affiliation>Department of Critical Care, rD' OR Institute for Research and Education and Post-Graduate Program Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharshar</LastName><ForeName>Tarek</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Intensive Care Medicine, Raymond Poincaré Hospital, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Human Histology and Animal Models, Institut Pasteur, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shehabi</LastName><ForeName>Yahya</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>School of Clinical Sciences, Faculty of Medicine, Monash University and Medical Center, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical School of Medicine, University New South Wales, Sydney, NSW, 2031, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skrobik</LastName><ForeName>Yoanna</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine, McGill University, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slooter</LastName><ForeName>Arjen J C</ForeName><Initials>AJC</Initials><AffiliationInfo><Affiliation>Department of Intensive Care Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Heidi A B</ForeName><Initials>HAB</Initials><AffiliationInfo><Affiliation>Division of Pediatric Cardiac Anesthesia, Department of Anesthesiology and Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL111111</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Intensive Care Med</MedlineTA><NlmUniqueID>7704851</NlmUniqueID><ISSNLinking>0342-4642</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Arthritis Care Res (Hoboken). 2010 May;62(5):640-6</RefSource><PMID 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Jun;42(6):962-71</RefSource><PMID Version="1">27075762</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Interv Aging. 2012;7:509-16</RefSource><PMID Version="1">23204843</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cognitive impairment</Keyword><Keyword MajorTopicYN="N">Delirium</Keyword><Keyword MajorTopicYN="N">Research agenda</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>06</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28612089</ArticleId><ArticleId IdType="doi">10.1007/s00134-017-4860-7</ArticleId><ArticleId IdType="pii">10.1007/s00134-017-4860-7</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Brésil</li><li>Canada</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Californie</li><li>Communauté de Madrid</li><li>Indiana</li><li>Manitoba</li><li>Maryland</li><li>Massachusetts</li><li>Ohio</li><li>Québec</li><li>Tennessee</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>Écosse</li><li>État de Rio de Janeiro</li><li>Île-de-France</li></region><settlement><li>Boston</li><li>Madrid</li><li>Melbourne</li><li>Montréal</li><li>Paris</li><li>Rio de Janeiro</li><li>Utrecht</li><li>Winnipeg</li><li>Édimbourg</li></settlement><orgName><li>Université McGill</li><li>Université d'Édimbourg</li><li>Université du Manitoba</li></orgName></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Pandharipande, Pratik P" sort="Pandharipande, Pratik P" uniqKey="Pandharipande P" first="Pratik P" last="Pandharipande">Pratik P. Pandharipande</name></region><name sortKey="Balas, Michele C" sort="Balas, Michele C" uniqKey="Balas M" first="Michele C" last="Balas">Michele C. Balas</name><name sortKey="Boustani, Malaz A" sort="Boustani, Malaz A" uniqKey="Boustani M" first="Malaz A" last="Boustani">Malaz A. Boustani</name><name sortKey="Devlin, John W" sort="Devlin, John W" uniqKey="Devlin J" first="John W" last="Devlin">John W. Devlin</name><name sortKey="Ely, E Wesley" sort="Ely, E Wesley" uniqKey="Ely E" first="E Wesley" last="Ely">E Wesley Ely</name><name sortKey="Han, Jin H" sort="Han, Jin H" uniqKey="Han J" first="Jin H" last="Han">Jin H. Han</name><name sortKey="Maldonado, Jose R" sort="Maldonado, Jose R" uniqKey="Maldonado J" first="José R" last="Maldonado">José R. Maldonado</name><name sortKey="Needham, Dale M" sort="Needham, Dale M" uniqKey="Needham D" first="Dale M" last="Needham">Dale M. Needham</name><name sortKey="Smith, Heidi A B" sort="Smith, Heidi A B" uniqKey="Smith H" first="Heidi A B" last="Smith">Heidi A B. Smith</name></country><country name="Canada"><region name="Manitoba"><name sortKey="Arora, Rakesh C" sort="Arora, Rakesh C" uniqKey="Arora R" first="Rakesh C" last="Arora">Rakesh C. Arora</name></region><name sortKey="Elefante, Julius" sort="Elefante, Julius" uniqKey="Elefante J" first="Julius" last="Elefante">Julius Elefante</name><name sortKey="Rose, Louise" sort="Rose, Louise" uniqKey="Rose L" first="Louise" last="Rose">Louise Rose</name><name sortKey="Skrobik, Yoanna" sort="Skrobik, Yoanna" uniqKey="Skrobik Y" first="Yoanna" last="Skrobik">Yoanna Skrobik</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="La Calle, Gabriel Heras" sort="La Calle, Gabriel Heras" uniqKey="La Calle G" first="Gabriel Heras" last="La Calle">Gabriel Heras La Calle</name></region></country><country name="Irlande (pays)"><noRegion><name sortKey="Cunningham, Colm" sort="Cunningham, Colm" uniqKey="Cunningham C" first="Colm" last="Cunningham">Colm Cunningham</name></noRegion></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Maclullich, Alasdair M" sort="Maclullich, Alasdair M" uniqKey="Maclullich A" first="Alasdair M" last="Maclullich">Alasdair M. Maclullich</name></region><name sortKey="Page, Valerie J" sort="Page, Valerie J" uniqKey="Page V" first="Valerie J" last="Page">Valerie J. Page</name></country><country name="Italie"><noRegion><name sortKey="Morandi, Alessandro" sort="Morandi, Alessandro" uniqKey="Morandi A" first="Alessandro" last="Morandi">Alessandro Morandi</name></noRegion></country><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Salluh, Jorge I F" sort="Salluh, Jorge I F" uniqKey="Salluh J" first="Jorge I F" last="Salluh">Jorge I F. Salluh</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Sharshar, Tarek" sort="Sharshar, Tarek" uniqKey="Sharshar T" first="Tarek" last="Sharshar">Tarek Sharshar</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name></region></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Slooter, Arjen J C" sort="Slooter, Arjen J C" uniqKey="Slooter A" first="Arjen J C" last="Slooter">Arjen J C. Slooter</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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