The intensive care medicine clinical research agenda in paediatrics.
Identifieur interne : 000181 ( PubMed/Checkpoint ); précédent : 000180; suivant : 000182The intensive care medicine clinical research agenda in paediatrics.
Auteurs : Mark J. Peters [Royaume-Uni] ; Andrew Argent [Afrique du Sud] ; Marino Festa [Australie] ; Stéphane Leteurtre [France] ; Jefferson Piva [Brésil] ; Ann Thompson [États-Unis] ; Douglas Willson [États-Unis] ; Pierre Tissières [France] ; Marisa Tucci [Canada] ; Jacques Lacroix [Canada]Source :
- Intensive care medicine [ 1432-1238 ] ; 2017.
Abstract
Intensive Care Medicine set us the task of outlining a global clinical research agenda for paediatric intensive care (PIC). In line with the clinical focus of this journal, we have limited this to research that may directly influence patient care.
DOI: 10.1007/s00134-017-4729-9
PubMed: 28315043
Affiliations:
- Afrique du Sud, Australie, Brésil, Canada, France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Pennsylvanie, Québec, Rio Grande do Sul, Virginie
- Londres, Montréal, Porto Alegre
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Peters</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Intensive Care Society Study Group (PICS-SG), UCL Great Ormond Street Institute of Child Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Paediatric Intensive Care Society Study Group (PICS-SG), UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Argent, Andrew" sort="Argent, Andrew" uniqKey="Argent A" first="Andrew" last="Argent">Andrew Argent</name><affiliation wicri:level="1"><nlm:affiliation>PICU, Red Cross War Memorial Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town, Republic of South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>PICU, Red Cross War Memorial Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Festa, Marino" sort="Festa, Marino" uniqKey="Festa M" first="Marino" last="Festa">Marino Festa</name><affiliation wicri:level="1"><nlm:affiliation>Paediatric Intensive Care Unit, the Children's Hospital at Westmead, the Sydney Children's Hospital Network, Westmead, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Paediatric Intensive Care Unit, the Children's Hospital at Westmead, the Sydney Children's Hospital Network, Westmead, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Leteurtre, Stephane" sort="Leteurtre, Stephane" uniqKey="Leteurtre S" first="Stéphane" last="Leteurtre">Stéphane Leteurtre</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Intensive Care 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type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Thompson, Ann" sort="Thompson, Ann" uniqKey="Thompson A" first="Ann" last="Thompson">Ann Thompson</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Acute Lung Injury and Sepsis Investigators (PALISI Network), Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Acute Lung Injury and Sepsis Investigators (PALISI Network), Children's Hospital of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Willson, Douglas" sort="Willson, Douglas" uniqKey="Willson D" first="Douglas" last="Willson">Douglas Willson</name><affiliation wicri:level="2"><nlm:affiliation>Executive Committee, PALISI, John Mickell Professor of Pediatric Critical Care, Children's Hospital of Richmond at VCU, Richmond, VA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Executive Committee, PALISI, John Mickell Professor of Pediatric Critical Care, Children's Hospital of Richmond at VCU, Richmond, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Tissieres, Pierre" sort="Tissieres, Pierre" uniqKey="Tissieres P" first="Pierre" last="Tissières">Pierre Tissières</name><affiliation wicri:level="1"><nlm:affiliation>Réanimation Pédiatrique et Médecine Néonatale, Hôpitaux Universitaires Paris-Sud AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Réanimation Pédiatrique et Médecine Néonatale, Hôpitaux Universitaires Paris-Sud AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Tucci, Marisa" sort="Tucci, Marisa" uniqKey="Tucci M" first="Marisa" last="Tucci">Marisa Tucci</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Interest Group, Canadian Critical Care Trials Group, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pediatric Interest Group, Canadian Critical Care Trials Group, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Lacroix, Jacques" sort="Lacroix, Jacques" uniqKey="Lacroix J" first="Jacques" last="Lacroix">Jacques Lacroix</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pediatric Intensive Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Sainte-Justine Hospital, Room 3431, 3175 Côte Sainte-Catherine, Montreal, QC, H3T 1C5, Canada. Jacques_lacroix@ssss.gouv.qc.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Intensive Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Sainte-Justine Hospital, Room 3431, 3175 Côte Sainte-Catherine, Montreal, QC, H3T 1C5</wicri:regionArea><wicri:noRegion>H3T 1C5</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28315043</idno><idno type="pmid">28315043</idno><idno type="doi">10.1007/s00134-017-4729-9</idno><idno type="wicri:Area/PubMed/Corpus">000F21</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F21</idno><idno type="wicri:Area/PubMed/Curation">000F18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F18</idno><idno type="wicri:Area/PubMed/Checkpoint">000F18</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The intensive care medicine clinical research agenda in paediatrics.</title><author><name sortKey="Peters, Mark J" sort="Peters, Mark J" uniqKey="Peters M" first="Mark J" last="Peters">Mark J. Peters</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Intensive Care Society Study Group (PICS-SG), UCL Great Ormond Street Institute of Child Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Paediatric Intensive Care Society Study Group (PICS-SG), UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Argent, Andrew" sort="Argent, Andrew" uniqKey="Argent A" first="Andrew" last="Argent">Andrew Argent</name><affiliation wicri:level="1"><nlm:affiliation>PICU, Red Cross War Memorial Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town, Republic of South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>PICU, Red Cross War Memorial Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Festa, Marino" sort="Festa, Marino" uniqKey="Festa M" first="Marino" last="Festa">Marino Festa</name><affiliation wicri:level="1"><nlm:affiliation>Paediatric Intensive Care Unit, the Children's Hospital at Westmead, the Sydney Children's Hospital Network, Westmead, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Paediatric Intensive Care Unit, the Children's Hospital at Westmead, the Sydney Children's Hospital Network, Westmead, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Leteurtre, Stephane" sort="Leteurtre, Stephane" uniqKey="Leteurtre S" first="Stéphane" last="Leteurtre">Stéphane Leteurtre</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Intensive Care Unit, University Lille, CHU Lille, EA 2694, Santé publique: épidémiologie et qualité des soins, 59000, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pediatric Intensive Care Unit, University Lille, CHU Lille, EA 2694, Santé publique: épidémiologie et qualité des soins, 59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Piva, Jefferson" sort="Piva, Jefferson" uniqKey="Piva J" first="Jefferson" last="Piva">Jefferson Piva</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Emergency and Critical Care Department, H Clinicas, UFRGS University, Porto Alegre, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pediatric Emergency and Critical Care Department, H Clinicas, UFRGS University, Porto Alegre</wicri:regionArea><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Thompson, Ann" sort="Thompson, Ann" uniqKey="Thompson A" first="Ann" last="Thompson">Ann Thompson</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Acute Lung Injury and Sepsis Investigators (PALISI Network), Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Acute Lung Injury and Sepsis Investigators (PALISI Network), Children's Hospital of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Willson, Douglas" sort="Willson, Douglas" uniqKey="Willson D" first="Douglas" last="Willson">Douglas Willson</name><affiliation wicri:level="2"><nlm:affiliation>Executive Committee, PALISI, John Mickell Professor of Pediatric Critical Care, Children's Hospital of Richmond at VCU, Richmond, VA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Executive Committee, PALISI, John Mickell Professor of Pediatric Critical Care, Children's Hospital of Richmond at VCU, Richmond, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Tissieres, Pierre" sort="Tissieres, Pierre" uniqKey="Tissieres P" first="Pierre" last="Tissières">Pierre Tissières</name><affiliation wicri:level="1"><nlm:affiliation>Réanimation Pédiatrique et Médecine Néonatale, Hôpitaux Universitaires Paris-Sud AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Réanimation Pédiatrique et Médecine Néonatale, Hôpitaux Universitaires Paris-Sud AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Tucci, Marisa" sort="Tucci, Marisa" uniqKey="Tucci M" first="Marisa" last="Tucci">Marisa Tucci</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Interest Group, Canadian Critical Care Trials Group, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pediatric Interest Group, Canadian Critical Care Trials Group, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Lacroix, Jacques" sort="Lacroix, Jacques" uniqKey="Lacroix J" first="Jacques" last="Lacroix">Jacques Lacroix</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pediatric Intensive Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Sainte-Justine Hospital, Room 3431, 3175 Côte Sainte-Catherine, Montreal, QC, H3T 1C5, Canada. Jacques_lacroix@ssss.gouv.qc.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Intensive Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Sainte-Justine Hospital, Room 3431, 3175 Côte Sainte-Catherine, Montreal, QC, H3T 1C5</wicri:regionArea><wicri:noRegion>H3T 1C5</wicri:noRegion></affiliation></author></analytic><series><title level="j">Intensive care medicine</title><idno type="eISSN">1432-1238</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intensive Care Medicine set us the task of outlining a global clinical research agenda for paediatric intensive care (PIC). In line with the clinical focus of this journal, we have limited this to research that may directly influence patient care.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28315043</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>18</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Mar</Month><Day>17</Day></PubDate></JournalIssue><Title>Intensive care medicine</Title><ISOAbbreviation>Intensive Care Med</ISOAbbreviation></Journal><ArticleTitle>The intensive care medicine clinical research agenda in paediatrics.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-017-4729-9</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Intensive Care Medicine set us the task of outlining a global clinical research agenda for paediatric intensive care (PIC). In line with the clinical focus of this journal, we have limited this to research that may directly influence patient care.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Clinician researchers from PIC research networks of varying degrees of formality from around the world were invited to answer two main questions: (1) What have been the major recent advances in paediatric critical care research? (2) What are the top 10 studies for the next 10 years?</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">(1) Inclusive databases are well established in many countries. These registries allow detailed observational studies and feasibility testing of clinical trial protocols. Recent trials are larger and more valuable, and (2) most common interventions in PIC are not evidenced-based. Clinical studies for the next 10 years should address this deficit, including: ventilation techniques and interfaces; fluid, transfusion and feeding strategies; optimal targets for vital signs; multiple organ failure definitions, mechanisms and treatments; trauma, prevention and treatment; improving safety; comfort of the patient and their family; appropriate care in the face of medical complexity; defining post-PICU outcomes; and improving knowledge generation and adoption, with novel trial design and implementation strategies. The group specifically highlighted the need for research in resource-limited environments wherein mortality remains often tenfold higher than in well-resourced settings.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Paediatric intensive care research has never been healthier, but many gaps in knowledge remain. We need to close these urgently. The impact of new knowledge will be greatest in resource-limited environments.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3653-4808</Identifier><AffiliationInfo><Affiliation>Paediatric Intensive Care Society Study Group (PICS-SG), UCL Great Ormond Street Institute of Child Health, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Argent</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>PICU, Red Cross War Memorial Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town, Republic of South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Festa</LastName><ForeName>Marino</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Paediatric Intensive Care Unit, the Children's Hospital at Westmead, the Sydney Children's Hospital Network, Westmead, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leteurtre</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Pediatric Intensive Care Unit, University Lille, CHU Lille, EA 2694, Santé publique: épidémiologie et qualité des soins, 59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piva</LastName><ForeName>Jefferson</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Pediatric Emergency and Critical Care Department, H Clinicas, UFRGS University, Porto Alegre, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Ann</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Pediatric Acute Lung Injury and Sepsis Investigators (PALISI Network), Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willson</LastName><ForeName>Douglas</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Executive Committee, PALISI, John Mickell Professor of Pediatric Critical Care, Children's Hospital of Richmond at VCU, Richmond, VA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tissières</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Réanimation Pédiatrique et Médecine Néonatale, Hôpitaux Universitaires Paris-Sud AP-HP, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tucci</LastName><ForeName>Marisa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Pediatric Interest Group, Canadian Critical Care Trials Group, Montreal, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pediatric Intensive Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Sainte-Justine Hospital, Room 3431, 3175 Côte Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lacroix</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Pediatric Intensive Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Sainte-Justine Hospital, Room 3431, 3175 Côte Sainte-Catherine, Montreal, QC, H3T 1C5, Canada. Jacques_lacroix@ssss.gouv.qc.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Intensive Care Med</MedlineTA><NlmUniqueID>7704851</NlmUniqueID><ISSNLinking>0342-4642</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>JAMA Pediatr. 2016 Jan;170(1):7-8</RefSource><PMID Version="1">26550766</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Blood Marrow Transplant. 2016 May;22(5):782-95</RefSource><PMID Version="1">26802323</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2012 Oct 10;308(14):1443-51</RefSource><PMID 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Version="1">27686343</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Transfusion. 2010 Nov;50(11):2328-35</RefSource><PMID Version="1">20529008</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMJ Open. 2015 Sep 18;5(9):e008522</RefSource><PMID Version="1">26384724</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Implement Sci. 2012 May 31;7:50</RefSource><PMID Version="1">22651257</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Children</Keyword><Keyword MajorTopicYN="N">Critical care</Keyword><Keyword MajorTopicYN="N">Intensive care</Keyword><Keyword MajorTopicYN="N">Paediatrics</Keyword><Keyword MajorTopicYN="N">Research</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28315043</ArticleId><ArticleId IdType="doi">10.1007/s00134-017-4729-9</ArticleId><ArticleId IdType="pii">10.1007/s00134-017-4729-9</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Brésil</li><li>Canada</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Pennsylvanie</li><li>Québec</li><li>Rio Grande do Sul</li><li>Virginie</li></region><settlement><li>Londres</li><li>Montréal</li><li>Porto Alegre</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Peters, Mark J" sort="Peters, Mark J" uniqKey="Peters M" first="Mark J" last="Peters">Mark J. Peters</name></region></country><country name="Afrique du Sud"><noRegion><name sortKey="Argent, Andrew" sort="Argent, Andrew" uniqKey="Argent A" first="Andrew" last="Argent">Andrew Argent</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Festa, Marino" sort="Festa, Marino" uniqKey="Festa M" first="Marino" last="Festa">Marino Festa</name></noRegion></country><country name="France"><noRegion><name sortKey="Leteurtre, Stephane" sort="Leteurtre, Stephane" uniqKey="Leteurtre S" first="Stéphane" last="Leteurtre">Stéphane Leteurtre</name></noRegion><name sortKey="Tissieres, Pierre" sort="Tissieres, Pierre" uniqKey="Tissieres P" first="Pierre" last="Tissières">Pierre Tissières</name></country><country name="Brésil"><region name="Rio Grande do Sul"><name sortKey="Piva, Jefferson" sort="Piva, Jefferson" uniqKey="Piva J" first="Jefferson" last="Piva">Jefferson Piva</name></region></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Thompson, Ann" sort="Thompson, Ann" uniqKey="Thompson A" first="Ann" last="Thompson">Ann Thompson</name></region><name sortKey="Willson, Douglas" sort="Willson, Douglas" uniqKey="Willson D" first="Douglas" last="Willson">Douglas Willson</name></country><country name="Canada"><region name="Québec"><name sortKey="Tucci, Marisa" sort="Tucci, Marisa" uniqKey="Tucci M" first="Marisa" last="Tucci">Marisa Tucci</name></region><name sortKey="Lacroix, Jacques" sort="Lacroix, Jacques" uniqKey="Lacroix J" first="Jacques" last="Lacroix">Jacques Lacroix</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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