The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF).
Identifieur interne : 000158 ( PubMed/Checkpoint ); précédent : 000157; suivant : 000159The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF).
Auteurs : N C Harvey [Royaume-Uni] ; E. Biver [Suisse] ; J-M Kaufman [Belgique] ; J. Bauer [Allemagne] ; J. Branco [Portugal] ; M L Brandi [Italie] ; O. Bruyère [Belgique] ; V. Coxam [France] ; A. Cruz-Jentoft [Espagne] ; E. Czerwinski [Pologne] ; H. Dimai [Autriche] ; P. Fardellone [France] ; F. Landi [Italie] ; J-Y Reginster [Belgique] ; B. Dawson-Hughes [États-Unis] ; J A Kanis [Royaume-Uni] ; R. Rizzoli [Suisse] ; C. Cooper [Royaume-Uni]Source :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [ 1433-2965 ] ; 2017.
Abstract
The place of calcium supplementation, with or without concomitant vitamin D supplementation, has been much debated in terms of both efficacy and safety. There have been numerous trials and meta-analyses of supplementation for fracture reduction, and associations with risk of myocardial infarction have been suggested in recent years. In this report, the product of an expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF), we review the evidence for the value of calcium supplementation, with or without vitamin D supplementation, for healthy musculoskeletal ageing. We conclude that (1) calcium and vitamin D supplementation leads to a modest reduction in fracture risk, although population-level intervention has not been shown to be an effective public health strategy; (2) supplementation with calcium alone for fracture reduction is not supported by the literature; (3) side effects of calcium supplementation include renal stones and gastrointestinal symptoms; (4) vitamin D supplementation, rather than calcium supplementation, may reduce falls risk; and (5) assertions of increased cardiovascular risk consequent to calcium supplementation are not convincingly supported by current evidence. In conclusion, we recommend, on the basis of the current evidence, that calcium supplementation, with concomitant vitamin D supplementation, is supported for patients at high risk of calcium and vitamin D insufficiency, and in those who are receiving treatment for osteoporosis.
DOI: 10.1007/s00198-016-3773-6
PubMed: 27761590
Affiliations:
- Allemagne, Autriche, Belgique, Espagne, France, Italie, Pologne, Portugal, Royaume-Uni, Suisse, États-Unis
- Communauté de Madrid, Hauts-de-France, Lombardie, Massachusetts, Picardie, Province de Flandre-Orientale, Province de Liège, Région flamande, Région wallonne
- Amiens, Gand, Liège, Madrid, Milan
- Université de Gand, Université de Liège
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF).</title><author><name sortKey="Harvey, N C" sort="Harvey, N C" uniqKey="Harvey N" first="N C" last="Harvey">N C Harvey</name><affiliation wicri:level="1"><nlm:affiliation>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Biver, E" sort="Biver, E" uniqKey="Biver E" first="E" last="Biver">E. Biver</name><affiliation wicri:level="1"><nlm:affiliation>Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Bone Diseases, University Hospitals Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Kaufman, J M" sort="Kaufman, J M" uniqKey="Kaufman J" first="J-M" last="Kaufman">J-M Kaufman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine, section Endocrinology, Ghent University, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, section Endocrinology, Ghent University, Ghent</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Bauer, J" sort="Bauer, J" uniqKey="Bauer J" first="J" last="Bauer">J. Bauer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Ammerländer Heerstrasse 114-118, 26129, Oldenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Ammerländer Heerstrasse 114-118, 26129, Oldenburg</wicri:regionArea><wicri:noRegion>26129, Oldenburg</wicri:noRegion><wicri:noRegion>26129, Oldenburg</wicri:noRegion><wicri:noRegion>Oldenburg</wicri:noRegion></affiliation></author><author><name sortKey="Branco, J" sort="Branco, J" uniqKey="Branco J" first="J" last="Branco">J. Branco</name><affiliation wicri:level="1"><nlm:affiliation>CEDOC - NOVA Medical School, UNL and Rheumatology Department, CHLO/Hospital Egas Moniz, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>CEDOC - NOVA Medical School, UNL and Rheumatology Department, CHLO/Hospital Egas Moniz, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Brandi, M L" sort="Brandi, M L" uniqKey="Brandi M" first="M L" last="Brandi">M L Brandi</name><affiliation wicri:level="1"><nlm:affiliation>Head, Bone and Mineral Metabolic Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Head, Bone and Mineral Metabolic Unit, Department of Surgery and Translational Medicine, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Bruyere, O" sort="Bruyere, O" uniqKey="Bruyere O" first="O" last="Bruyère">O. Bruyère</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Coxam, V" sort="Coxam, V" uniqKey="Coxam V" first="V" last="Coxam">V. Coxam</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000, Clermont-Ferrand</wicri:regionArea><wicri:noRegion>63000, Clermont-Ferrand</wicri:noRegion><wicri:noRegion>63000, Clermont-Ferrand</wicri:noRegion></affiliation></author><author><name sortKey="Cruz Jentoft, A" sort="Cruz Jentoft, A" uniqKey="Cruz Jentoft A" first="A" last="Cruz-Jentoft">A. Cruz-Jentoft</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Czerwinski, E" sort="Czerwinski, E" uniqKey="Czerwinski E" first="E" last="Czerwinski">E. Czerwinski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bone and Joint Diseases, Faculty of Health Sciences, Krakow Medical Centre, Jagiellonian University, Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Bone and Joint Diseases, Faculty of Health Sciences, Krakow Medical Centre, Jagiellonian University, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Dimai, H" sort="Dimai, H" uniqKey="Dimai H" first="H" last="Dimai">H. Dimai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Fardellone, P" sort="Fardellone, P" uniqKey="Fardellone P" first="P" last="Fardellone">P. Fardellone</name><affiliation wicri:level="3"><nlm:affiliation>CHU Amiens, Université Picardie - Jules Verne, INSERM U 1088, Amiens, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Amiens, Université Picardie - Jules Verne, INSERM U 1088, Amiens</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Picardie</region><settlement type="city">Amiens</settlement></placeName></affiliation></author><author><name sortKey="Landi, F" sort="Landi, F" uniqKey="Landi F" first="F" last="Landi">F. Landi</name><affiliation wicri:level="3"><nlm:affiliation>Geriatric Department, Catholic University of Sacred Heart, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Department, Catholic University of Sacred Heart, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Reginster, J Y" sort="Reginster, J Y" uniqKey="Reginster J" first="J-Y" last="Reginster">J-Y Reginster</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Dawson Hughes, B" sort="Dawson Hughes, B" uniqKey="Dawson Hughes B" first="B" last="Dawson-Hughes">B. Dawson-Hughes</name><affiliation wicri:level="2"><nlm:affiliation>Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kanis, J A" sort="Kanis, J A" uniqKey="Kanis J" first="J A" last="Kanis">J A Kanis</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Rizzoli, R" sort="Rizzoli, R" uniqKey="Rizzoli R" first="R" last="Rizzoli">R. Rizzoli</name><affiliation wicri:level="1"><nlm:affiliation>Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Bone Diseases, University Hospitals Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C" last="Cooper">C. Cooper</name><affiliation wicri:level="1"><nlm:affiliation>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. cc@mrc.soton.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27761590</idno><idno type="pmid">27761590</idno><idno type="doi">10.1007/s00198-016-3773-6</idno><idno type="wicri:Area/PubMed/Corpus">001115</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001115</idno><idno type="wicri:Area/PubMed/Curation">001112</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001112</idno><idno type="wicri:Area/PubMed/Checkpoint">001112</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001112</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF).</title><author><name sortKey="Harvey, N C" sort="Harvey, N C" uniqKey="Harvey N" first="N C" last="Harvey">N C Harvey</name><affiliation wicri:level="1"><nlm:affiliation>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Biver, E" sort="Biver, E" uniqKey="Biver E" first="E" last="Biver">E. Biver</name><affiliation wicri:level="1"><nlm:affiliation>Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Bone Diseases, University Hospitals Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Kaufman, J M" sort="Kaufman, J M" uniqKey="Kaufman J" first="J-M" last="Kaufman">J-M Kaufman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine, section Endocrinology, Ghent University, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, section Endocrinology, Ghent University, Ghent</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Bauer, J" sort="Bauer, J" uniqKey="Bauer J" first="J" last="Bauer">J. Bauer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Ammerländer Heerstrasse 114-118, 26129, Oldenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Ammerländer Heerstrasse 114-118, 26129, Oldenburg</wicri:regionArea><wicri:noRegion>26129, Oldenburg</wicri:noRegion><wicri:noRegion>26129, Oldenburg</wicri:noRegion><wicri:noRegion>Oldenburg</wicri:noRegion></affiliation></author><author><name sortKey="Branco, J" sort="Branco, J" uniqKey="Branco J" first="J" last="Branco">J. Branco</name><affiliation wicri:level="1"><nlm:affiliation>CEDOC - NOVA Medical School, UNL and Rheumatology Department, CHLO/Hospital Egas Moniz, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>CEDOC - NOVA Medical School, UNL and Rheumatology Department, CHLO/Hospital Egas Moniz, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Brandi, M L" sort="Brandi, M L" uniqKey="Brandi M" first="M L" last="Brandi">M L Brandi</name><affiliation wicri:level="1"><nlm:affiliation>Head, Bone and Mineral Metabolic Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Head, Bone and Mineral Metabolic Unit, Department of Surgery and Translational Medicine, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Bruyere, O" sort="Bruyere, O" uniqKey="Bruyere O" first="O" last="Bruyère">O. Bruyère</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Coxam, V" sort="Coxam, V" uniqKey="Coxam V" first="V" last="Coxam">V. Coxam</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000, Clermont-Ferrand</wicri:regionArea><wicri:noRegion>63000, Clermont-Ferrand</wicri:noRegion><wicri:noRegion>63000, Clermont-Ferrand</wicri:noRegion></affiliation></author><author><name sortKey="Cruz Jentoft, A" sort="Cruz Jentoft, A" uniqKey="Cruz Jentoft A" first="A" last="Cruz-Jentoft">A. Cruz-Jentoft</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Czerwinski, E" sort="Czerwinski, E" uniqKey="Czerwinski E" first="E" last="Czerwinski">E. Czerwinski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bone and Joint Diseases, Faculty of Health Sciences, Krakow Medical Centre, Jagiellonian University, Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Bone and Joint Diseases, Faculty of Health Sciences, Krakow Medical Centre, Jagiellonian University, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Dimai, H" sort="Dimai, H" uniqKey="Dimai H" first="H" last="Dimai">H. Dimai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Fardellone, P" sort="Fardellone, P" uniqKey="Fardellone P" first="P" last="Fardellone">P. Fardellone</name><affiliation wicri:level="3"><nlm:affiliation>CHU Amiens, Université Picardie - Jules Verne, INSERM U 1088, Amiens, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Amiens, Université Picardie - Jules Verne, INSERM U 1088, Amiens</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Picardie</region><settlement type="city">Amiens</settlement></placeName></affiliation></author><author><name sortKey="Landi, F" sort="Landi, F" uniqKey="Landi F" first="F" last="Landi">F. Landi</name><affiliation wicri:level="3"><nlm:affiliation>Geriatric Department, Catholic University of Sacred Heart, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Department, Catholic University of Sacred Heart, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Reginster, J Y" sort="Reginster, J Y" uniqKey="Reginster J" first="J-Y" last="Reginster">J-Y Reginster</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Dawson Hughes, B" sort="Dawson Hughes, B" uniqKey="Dawson Hughes B" first="B" last="Dawson-Hughes">B. Dawson-Hughes</name><affiliation wicri:level="2"><nlm:affiliation>Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kanis, J A" sort="Kanis, J A" uniqKey="Kanis J" first="J A" last="Kanis">J A Kanis</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Rizzoli, R" sort="Rizzoli, R" uniqKey="Rizzoli R" first="R" last="Rizzoli">R. Rizzoli</name><affiliation wicri:level="1"><nlm:affiliation>Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Bone Diseases, University Hospitals Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C" last="Cooper">C. Cooper</name><affiliation wicri:level="1"><nlm:affiliation>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. cc@mrc.soton.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author></analytic><series><title level="j">Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</title><idno type="eISSN">1433-2965</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The place of calcium supplementation, with or without concomitant vitamin D supplementation, has been much debated in terms of both efficacy and safety. There have been numerous trials and meta-analyses of supplementation for fracture reduction, and associations with risk of myocardial infarction have been suggested in recent years. In this report, the product of an expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF), we review the evidence for the value of calcium supplementation, with or without vitamin D supplementation, for healthy musculoskeletal ageing. We conclude that (1) calcium and vitamin D supplementation leads to a modest reduction in fracture risk, although population-level intervention has not been shown to be an effective public health strategy; (2) supplementation with calcium alone for fracture reduction is not supported by the literature; (3) side effects of calcium supplementation include renal stones and gastrointestinal symptoms; (4) vitamin D supplementation, rather than calcium supplementation, may reduce falls risk; and (5) assertions of increased cardiovascular risk consequent to calcium supplementation are not convincingly supported by current evidence. In conclusion, we recommend, on the basis of the current evidence, that calcium supplementation, with concomitant vitamin D supplementation, is supported for patients at high risk of calcium and vitamin D insufficiency, and in those who are receiving treatment for osteoporosis.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27761590</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>20</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1433-2965</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</Title><ISOAbbreviation>Osteoporos Int</ISOAbbreviation></Journal><ArticleTitle>The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF).</ArticleTitle><Pagination><MedlinePgn>447-462</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00198-016-3773-6</ELocationID><Abstract><AbstractText>The place of calcium supplementation, with or without concomitant vitamin D supplementation, has been much debated in terms of both efficacy and safety. There have been numerous trials and meta-analyses of supplementation for fracture reduction, and associations with risk of myocardial infarction have been suggested in recent years. In this report, the product of an expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF), we review the evidence for the value of calcium supplementation, with or without vitamin D supplementation, for healthy musculoskeletal ageing. We conclude that (1) calcium and vitamin D supplementation leads to a modest reduction in fracture risk, although population-level intervention has not been shown to be an effective public health strategy; (2) supplementation with calcium alone for fracture reduction is not supported by the literature; (3) side effects of calcium supplementation include renal stones and gastrointestinal symptoms; (4) vitamin D supplementation, rather than calcium supplementation, may reduce falls risk; and (5) assertions of increased cardiovascular risk consequent to calcium supplementation are not convincingly supported by current evidence. In conclusion, we recommend, on the basis of the current evidence, that calcium supplementation, with concomitant vitamin D supplementation, is supported for patients at high risk of calcium and vitamin D insufficiency, and in those who are receiving treatment for osteoporosis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harvey</LastName><ForeName>N C</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biver</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaufman</LastName><ForeName>J-M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, section Endocrinology, Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Ammerländer Heerstrasse 114-118, 26129, Oldenburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Branco</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CEDOC - NOVA Medical School, UNL and Rheumatology Department, CHLO/Hospital Egas Moniz, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brandi</LastName><ForeName>M L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Head, Bone and Mineral Metabolic Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruyère</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coxam</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000, Clermont-Ferrand, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cruz-Jentoft</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czerwinski</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Bone and Joint Diseases, Faculty of Health Sciences, Krakow Medical Centre, Jagiellonian University, Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dimai</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fardellone</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>CHU Amiens, Université Picardie - Jules Verne, INSERM U 1088, Amiens, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landi</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Geriatric Department, Catholic University of Sacred Heart, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reginster</LastName><ForeName>J-Y</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dawson-Hughes</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanis</LastName><ForeName>J A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Health and Ageing, Catholic University of Australia, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rizzoli</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>C</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3510-0709</Identifier><AffiliationInfo><Affiliation>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. cc@mrc.soton.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. cc@mrc.soton.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research Centre, University of Oxford, Oxford, UK. cc@mrc.soton.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>21231</GrantID><Agency>Arthritis Research UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_U147585819</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>17702</GrantID><Agency>Arthritis Research UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UP_A620_1014</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12011/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>HTA/10/33/04</GrantID><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Osteoporos Int</MedlineTA><NlmUniqueID>9100105</NlmUniqueID><ISSNLinking>0937-941X</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2005 May 7-13;365(9471):1621-8</RefSource><PMID Version="1">15885294</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Maturitas. 2014 Sep;79(1):122-32</RefSource><PMID Version="1">25082206</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Soc Nephrol. 2009 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Version="1">26800972</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Calcium supplementation</Keyword><Keyword MajorTopicYN="N">Fracture reduction</Keyword><Keyword MajorTopicYN="N">Myocardial infarction</Keyword><Keyword MajorTopicYN="N">Vitamin D supplementation</Keyword></KeywordList><CoiStatement>DisclosuresN. Harvey has received consultancy, lecture fees and honoraria from Alliance for Better Bone Health, AMGEN, MSD, Eli Lilly, Servier, Shire, Consilient Healthcare and Internis Pharma; C. Cooper has received consultancy, lecture fees and honoraria from AMGEN, GSK, Alliance for Better Bone Health, MSD, Eli Lilly, Pfizer, Novartis, Servier, Medtronic and Roche. V. Coxam has received Institutional funding and honoraria for an oral intervention at a scientific meeting Le Centre National Interprofessionnel de l'Economie Laitière (CNIEL); J.-M. Kaufman has received speaker or consultant fees from Amgen, Eli Lilly, Servier; E. Czerwinski has received research support and lecture fees from Amgen; O. Bruyere has received grant support from IBSA, MSD, Nutraveris, Novartis, Pfizer, Rottapharm, Servier, and Theramex; consulting or lecture fees from Bayer, Genevrier, IBSA, Rottapharm, Servier, SMB and TRB Chemedica. B. Dawson-Hughes has received research funding and consultancy from Pfizer Inc. E. Biver, J. Bauer, J. Branco, M.L. Brandi, A. Cruz-Jentoft, H. Dimai, P. Fardellone, F. Landi, J.Y. Reginster, J.A. Kanis, R. Rizzoli that they have no conflict of interest. ESCEO and IOF disclosures: none in relation to this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27761590</ArticleId><ArticleId IdType="doi">10.1007/s00198-016-3773-6</ArticleId><ArticleId IdType="pii">10.1007/s00198-016-3773-6</ArticleId><ArticleId IdType="pmc">PMC5274536</ArticleId><ArticleId IdType="mid">EMS71121</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pologne</li><li>Portugal</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Communauté de Madrid</li><li>Hauts-de-France</li><li>Lombardie</li><li>Massachusetts</li><li>Picardie</li><li>Province de Flandre-Orientale</li><li>Province de Liège</li><li>Région flamande</li><li>Région wallonne</li></region><settlement><li>Amiens</li><li>Gand</li><li>Liège</li><li>Madrid</li><li>Milan</li></settlement><orgName><li>Université de Gand</li><li>Université de Liège</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Harvey, N C" sort="Harvey, N C" uniqKey="Harvey N" first="N C" last="Harvey">N C Harvey</name></noRegion><name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C" last="Cooper">C. Cooper</name><name sortKey="Kanis, J A" sort="Kanis, J A" uniqKey="Kanis J" first="J A" last="Kanis">J A Kanis</name></country><country name="Suisse"><noRegion><name sortKey="Biver, E" sort="Biver, E" uniqKey="Biver E" first="E" last="Biver">E. Biver</name></noRegion><name sortKey="Rizzoli, R" sort="Rizzoli, R" uniqKey="Rizzoli R" first="R" last="Rizzoli">R. Rizzoli</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Kaufman, J M" sort="Kaufman, J M" uniqKey="Kaufman J" first="J-M" last="Kaufman">J-M Kaufman</name></region><name sortKey="Bruyere, O" sort="Bruyere, O" uniqKey="Bruyere O" first="O" last="Bruyère">O. Bruyère</name><name sortKey="Reginster, J Y" sort="Reginster, J Y" uniqKey="Reginster J" first="J-Y" last="Reginster">J-Y Reginster</name></country><country name="Allemagne"><noRegion><name sortKey="Bauer, J" sort="Bauer, J" uniqKey="Bauer J" first="J" last="Bauer">J. Bauer</name></noRegion></country><country name="Portugal"><noRegion><name sortKey="Branco, J" sort="Branco, J" uniqKey="Branco J" first="J" last="Branco">J. Branco</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Brandi, M L" sort="Brandi, M L" uniqKey="Brandi M" first="M L" last="Brandi">M L Brandi</name></noRegion><name sortKey="Landi, F" sort="Landi, F" uniqKey="Landi F" first="F" last="Landi">F. Landi</name></country><country name="France"><noRegion><name sortKey="Coxam, V" sort="Coxam, V" uniqKey="Coxam V" first="V" last="Coxam">V. Coxam</name></noRegion><name sortKey="Fardellone, P" sort="Fardellone, P" uniqKey="Fardellone P" first="P" last="Fardellone">P. Fardellone</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Cruz Jentoft, A" sort="Cruz Jentoft, A" uniqKey="Cruz Jentoft A" first="A" last="Cruz-Jentoft">A. Cruz-Jentoft</name></region></country><country name="Pologne"><noRegion><name sortKey="Czerwinski, E" sort="Czerwinski, E" uniqKey="Czerwinski E" first="E" last="Czerwinski">E. Czerwinski</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Dimai, H" sort="Dimai, H" uniqKey="Dimai H" first="H" last="Dimai">H. Dimai</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Dawson Hughes, B" sort="Dawson Hughes, B" uniqKey="Dawson Hughes B" first="B" last="Dawson-Hughes">B. Dawson-Hughes</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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