Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Identifieur interne : 002C85 ( Pmc/Curation ); précédent : 002C84; suivant : 002C86Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Auteurs : Brian M. Wolpin [États-Unis] ; Cosmeri Rizzato [Allemagne] ; Peter Kraft [États-Unis] ; Charles Kooperberg [États-Unis] ; Gloria M. Petersen [États-Unis] ; Zhaoming Wang [États-Unis] ; Alan A. Arslan [États-Unis] ; Laura Beane-Freeman [États-Unis] ; Paige M. Bracci [États-Unis] ; Julie Buring [États-Unis] ; Federico Canzian [Allemagne] ; Eric J. Duell [Espagne] ; Steven Gallinger [Canada] ; Graham G. Giles [Australie] ; Gary E. Goodman [États-Unis] ; Phyllis J. Goodman [États-Unis] ; Eric J. Jacobs [États-Unis] ; Aruna Kamineni [États-Unis] ; Alison P. Klein [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Matthew H. Kulke [États-Unis] ; Donghui Li [États-Unis] ; Núria Malats [Espagne] ; Sara H. Olson [États-Unis] ; Harvey A. Risch [États-Unis] ; Howard D. Sesso [États-Unis] ; Kala Visvanathan [États-Unis] ; Emily White [États-Unis] ; Wei Zheng [États-Unis] ; Christian C. Abnet [États-Unis] ; Demetrius Albanes [États-Unis] ; Gabriella Andreotti [États-Unis] ; Melissa A. Austin [États-Unis] ; Richard Barfield [États-Unis] ; Daniela Basso [Italie] ; Sonja I. Berndt [États-Unis] ; Marie-Christine Boutron-Ruault [France] ; Michelle Brotzman [États-Unis] ; Markus W. Büchler [Allemagne] ; H. Bas Bueno-De-Mesquita [Pays-Bas, Royaume-Uni] ; Peter Bugert [Allemagne] ; Laurie Burdette [États-Unis] ; Daniele Campa [Allemagne] ; Neil E. Caporaso [États-Unis] ; Gabriele Capurso [Italie] ; Charles Chung [États-Unis] ; Michelle Cotterchio [Canada] ; Eithne Costello [Royaume-Uni] ; Joanne Elena [États-Unis] ; Niccola Funel [Italie] ; J. Michael Gaziano [États-Unis] ; Nathalia A. Giese [Allemagne] ; Edward L. Giovannucci [États-Unis] ; Michael Goggins [États-Unis] ; Megan J. Gorman [États-Unis] ; Myron Gross [États-Unis] ; Christopher A. Haiman [États-Unis] ; Manal Hassan [États-Unis] ; Kathy J. Helzlsouer [États-Unis] ; Brian E. Henderson [États-Unis] ; Elizabeth A. Holly [États-Unis] ; Nan Hu [États-Unis] ; David J. Hunter [États-Unis] ; Federico Innocenti [États-Unis] ; Mazda Jenab [France] ; Rudolf Kaaks [Allemagne] ; Timothy J. Key [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Eric A. Klein [États-Unis] ; Manolis Kogevinas [Espagne, Grèce] ; Vittorio Krogh [Italie] ; Juozas Kupcinskas [Lituanie] ; Robert C. Kurtz [États-Unis] ; Andrea Lacroix [États-Unis] ; Maria T. Landi [États-Unis] ; Stefano Landi [Italie] ; Loic Le Marchand [États-Unis] ; Andrea Mambrini [Italie] ; Satu Mannisto [Finlande] ; Roger L. Milne [Australie] ; Yusuke Nakamura [Japon] ; Ann L. Oberg [États-Unis] ; Kouros Owzar [États-Unis] ; Alpa V. Patel [États-Unis] ; Petra H. M. Peeters [Pays-Bas, Royaume-Uni] ; Ulrike Peters [États-Unis] ; Raffaele Pezzilli [Italie] ; Ada Piepoli [Italie] ; Miquel Porta [Espagne] ; Francisco X. Real [Espagne] ; Elio Riboli [Royaume-Uni] ; Nathaniel Rothman [États-Unis] ; Aldo Scarpa [Italie] ; Xiao-Ou Shu [États-Unis] ; Debra T. Silverman [États-Unis] ; Pavel Soucek [République tchèque] ; Malin Sund [Suède] ; Renata Talar-Wojnarowska [Pologne] ; Philip R. Taylor [États-Unis] ; George E. Theodoropoulos [Grèce] ; Mark Thornquist [États-Unis] ; Anne Tj Nneland [Danemark] ; Geoffrey S. Tobias [États-Unis] ; Dimitrios Trichopoulos [États-Unis, Grèce] ; Pavel Vodicka [République tchèque] ; Jean Wactawski-Wende [États-Unis] ; Nicolas Wentzensen [États-Unis] ; Chen Wu [États-Unis] ; Herbert Yu [États-Unis] ; Kai Yu [États-Unis] ; Anne Zeleniuch-Jacquotte [États-Unis] ; Robert Hoover [États-Unis] ; Patricia Hartge [États-Unis] ; Charles Fuchs [États-Unis] ; Stephen J. Chanock [États-Unis] ; Rachael S. Stolzenberg-Solomon [États-Unis] ; Laufey T. Amundadottir [États-Unis]Source :
- Nature genetics [ 1061-4036 ] ; 2014.
Abstract
We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (
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DOI: 10.1038/ng.3052
PubMed: 25086665
PubMed Central: 4191666
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Wolpin</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Rizzato, Cosmeri" sort="Rizzato, Cosmeri" uniqKey="Rizzato C" first="Cosmeri" last="Rizzato">Cosmeri Rizzato</name><affiliation wicri:level="1"><nlm:aff id="A3">Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="1"><nlm:aff id="A6">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, Gloria M" sort="Petersen, Gloria M" uniqKey="Petersen G" first="Gloria M." last="Petersen">Gloria M. 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Klein</name><affiliation wicri:level="1"><nlm:aff id="A24">Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:aff id="A26">The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Kulke, Matthew H" sort="Kulke, Matthew H" uniqKey="Kulke M" first="Matthew H." last="Kulke">Matthew H. Kulke</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Li, Donghui" sort="Li, Donghui" uniqKey="Li D" first="Donghui" last="Li">Donghui Li</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation wicri:level="1"><nlm:aff id="A28">Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H." last="Olson">Sara H. Olson</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut</wicri:regionArea></affiliation></author><author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D." last="Sesso">Howard D. Sesso</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><affiliation wicri:level="1"><nlm:aff id="A31">Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="A32">Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A34">Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Austin, Melissa A" sort="Austin, Melissa A" uniqKey="Austin M" first="Melissa A." last="Austin">Melissa A. Austin</name><affiliation wicri:level="1"><nlm:aff id="A33">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Barfield, Richard" sort="Barfield, Richard" uniqKey="Barfield R" first="Richard" last="Barfield">Richard Barfield</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Basso, Daniela" sort="Basso, Daniela" uniqKey="Basso D" first="Daniela" last="Basso">Daniela Basso</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padua</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="1"><nlm:aff id="A37">Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health Team, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health Team, F-94805, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">University Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris Sud, UMRS 1018, F-94805, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">IGR, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IGR, F-94805, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Brotzman, Michelle" sort="Brotzman, Michelle" uniqKey="Brotzman M" first="Michelle" last="Brotzman">Michelle Brotzman</name><affiliation wicri:level="1"><nlm:aff id="A40">Westat, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Westat, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W." last="Büchler">Markus W. Büchler</name><affiliation wicri:level="1"><nlm:aff id="A41">Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="A42">National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A43">Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute of Transfusion Medicine and Immunology, Heidelberg University, Medical Faculty Mannheim, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Transfusion Medicine and Immunology, Heidelberg University, Medical Faculty Mannheim, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim</wicri:regionArea></affiliation></author><author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation wicri:level="1"><nlm:aff id="A46">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E." last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Capurso, Gabriele" sort="Capurso, Gabriele" uniqKey="Capurso G" first="Gabriele" last="Capurso">Gabriele Capurso</name><affiliation wicri:level="1"><nlm:aff id="A47">Digestive and Liver Disease Unit, ‘Sapienza’ University of Rome, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Digestive and Liver Disease Unit, ‘Sapienza’ University of Rome, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Charles" sort="Chung, Charles" uniqKey="Chung C" first="Charles" last="Chung">Charles Chung</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation wicri:level="1"><nlm:aff id="A48">Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Care Ontario, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A49">Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name><affiliation wicri:level="1"><nlm:aff id="A50">National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Elena, Joanne" sort="Elena, Joanne" uniqKey="Elena J" first="Joanne" last="Elena">Joanne Elena</name><affiliation wicri:level="1"><nlm:aff id="A51">Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Funel, Niccola" sort="Funel, Niccola" uniqKey="Funel N" first="Niccola" last="Funel">Niccola Funel</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J. Michael" last="Gaziano">J. Michael Gaziano</name><affiliation wicri:level="1"><nlm:aff id="A14">Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Massachusetts Veteran’s Epidemiology, Research, and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts Veteran’s Epidemiology, Research, and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A." last="Giese">Nathalia A. Giese</name><affiliation wicri:level="1"><nlm:aff id="A41">Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Goggins, Michael" sort="Goggins, Michael" uniqKey="Goggins M" first="Michael" last="Goggins">Michael Goggins</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Gorman, Megan J" sort="Gorman, Megan J" uniqKey="Gorman M" first="Megan J." last="Gorman">Megan J. Gorman</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Gross, Myron" sort="Gross, Myron" uniqKey="Gross M" first="Myron" last="Gross">Myron Gross</name><affiliation wicri:level="1"><nlm:aff id="A59">Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="A60">Preventive Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Preventive Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Hassan, Manal" sort="Hassan, Manal" uniqKey="Hassan M" first="Manal" last="Hassan">Manal Hassan</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J." last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation wicri:level="1"><nlm:aff id="A61">Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="A62">Cancer Prevention, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A." last="Holly">Elizabeth A. Holly</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Nan" sort="Hu, Nan" uniqKey="Hu N" first="Nan" last="Hu">Nan Hu</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A63">Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A64">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Innocenti, Federico" sort="Innocenti, Federico" uniqKey="Innocenti F" first="Federico" last="Innocenti">Federico Innocenti</name><affiliation wicri:level="1"><nlm:aff id="A65">The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation wicri:level="1"><nlm:aff id="A66">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="1"><nlm:aff id="A46">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J." last="Key">Timothy J. Key</name><affiliation wicri:level="1"><nlm:aff id="A67">Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A68">School of Clinical Medicine, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Medicine, University of Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Eric A" sort="Klein, Eric A" uniqKey="Klein E" first="Eric A." last="Klein">Eric A. Klein</name><affiliation wicri:level="1"><nlm:aff id="A69">Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:aff id="A70">Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar Institute of Medical Research (IMIM), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">National School of Public Health, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>National School of Public Health, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="1"><nlm:aff id="A73">Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Kupcinskas, Juozas" sort="Kupcinskas, Juozas" uniqKey="Kupcinskas J" first="Juozas" last="Kupcinskas">Juozas Kupcinskas</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas</wicri:regionArea></affiliation></author><author><name sortKey="Kurtz, Robert C" sort="Kurtz, Robert C" uniqKey="Kurtz R" first="Robert C." last="Kurtz">Robert C. Kurtz</name><affiliation wicri:level="1"><nlm:aff id="A75">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation wicri:level="1"><nlm:aff id="A6">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T." last="Landi">Maria T. Landi</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Landi, Stefano" sort="Landi, Stefano" uniqKey="Landi S" first="Stefano" last="Landi">Stefano Landi</name><affiliation wicri:level="1"><nlm:aff id="A76">Department of Biology, University of Pisa, Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea></affiliation></author><author><name sortKey="Mambrini, Andrea" sort="Mambrini, Andrea" uniqKey="Mambrini A" first="Andrea" last="Mambrini">Andrea Mambrini</name><affiliation wicri:level="1"><nlm:aff id="A78">Oncology Department, ASL1 Massa Carrara, Massa Carrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Oncology Department, ASL1 Massa Carrara, Massa Carrara</wicri:regionArea></affiliation></author><author><name sortKey="Mannisto, Satu" sort="Mannisto, Satu" uniqKey="Mannisto S" first="Satu" last="Mannisto">Satu Mannisto</name><affiliation wicri:level="1"><nlm:aff id="A79">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="A18">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation wicri:level="1"><nlm:aff id="A80">Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L." last="Oberg">Ann L. Oberg</name><affiliation wicri:level="1"><nlm:aff id="A81">Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Owzar, Kouros" sort="Owzar, Kouros" uniqKey="Owzar K" first="Kouros" last="Owzar">Kouros Owzar</name><affiliation wicri:level="1"><nlm:aff id="A82">Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V." last="Patel">Alpa V. Patel</name><affiliation wicri:level="1"><nlm:aff id="A22">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H. M." last="Peeters">Petra H. M. Peeters</name><affiliation wicri:level="1"><nlm:aff id="A83">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A84">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A85">Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Pezzilli, Raffaele" sort="Pezzilli, Raffaele" uniqKey="Pezzilli R" first="Raffaele" last="Pezzilli">Raffaele Pezzilli</name><affiliation wicri:level="1"><nlm:aff id="A86">Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Piepoli, Ada" sort="Piepoli, Ada" uniqKey="Piepoli A" first="Ada" last="Piepoli">Ada Piepoli</name><affiliation wicri:level="1"><nlm:aff id="A87">Department of Gastroenterology, Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gastroenterology, Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo</wicri:regionArea></affiliation></author><author><name sortKey="Porta, Miquel" sort="Porta, Miquel" uniqKey="Porta M" first="Miquel" last="Porta">Miquel Porta</name><affiliation wicri:level="1"><nlm:aff id="A71">Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar Institute of Medical Research (IMIM), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">School of Medicine, Universitat Autònoma de Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>School of Medicine, Universitat Autònoma de Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A89">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea></affiliation></author><author><name sortKey="Real, Francisco X" sort="Real, Francisco X" uniqKey="Real F" first="Francisco X." last="Real">Francisco X. Real</name><affiliation wicri:level="1"><nlm:aff id="A90">Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="1"><nlm:aff id="A44">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name><affiliation wicri:level="1"><nlm:aff id="A92">ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona</wicri:regionArea></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A34">Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T." last="Silverman">Debra T. Silverman</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Soucek, Pavel" sort="Soucek, Pavel" uniqKey="Soucek P" first="Pavel" last="Soucek">Pavel Soucek</name><affiliation wicri:level="1"><nlm:aff id="A93">Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Surgical and Peroperative Sciences, Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical and Peroperative Sciences, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Talar Wojnarowska, Renata" sort="Talar Wojnarowska, Renata" uniqKey="Talar Wojnarowska R" first="Renata" last="Talar-Wojnarowska">Renata Talar-Wojnarowska</name><affiliation wicri:level="1"><nlm:aff id="A95">Department of Digestive Tract Diseases, Medical University of Łodz, Łodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz</wicri:regionArea></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Theodoropoulos, George E" sort="Theodoropoulos, George E" uniqKey="Theodoropoulos G" first="George E." last="Theodoropoulos">George E. Theodoropoulos</name><affiliation wicri:level="1"><nlm:aff id="A96">1st Propaideutic Surgical Department, Hippocration University Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Propaideutic Surgical Department, Hippocration University Hospital, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><affiliation wicri:level="1"><nlm:aff id="A6">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="1"><nlm:aff id="A97">Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Tobias, Geoffrey S" sort="Tobias, Geoffrey S" uniqKey="Tobias G" first="Geoffrey S." last="Tobias">Geoffrey S. Tobias</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A98">Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Bureau of Epidemiologic Research, Academy of Athens, Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A99">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Vodicka, Pavel" sort="Vodicka, Pavel" uniqKey="Vodicka P" first="Pavel" last="Vodicka">Pavel Vodicka</name><affiliation wicri:level="1"><nlm:aff id="A100">Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation wicri:level="1"><nlm:aff id="A101">Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York</wicri:regionArea></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Chen" sort="Wu, Chen" uniqKey="Wu C" first="Chen" last="Wu">Chen Wu</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Medicine, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">New York University Cancer Institute, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York University Cancer Institute, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Fuchs, Charles" sort="Fuchs, Charles" uniqKey="Fuchs C" first="Charles" last="Fuchs">Charles Fuchs</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Stolzenberg Solomon, Rachael S" sort="Stolzenberg Solomon, Rachael S" uniqKey="Stolzenberg Solomon R" first="Rachael S." last="Stolzenberg-Solomon">Rachael S. Stolzenberg-Solomon</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Amundadottir, Laufey T" sort="Amundadottir, Laufey T" uniqKey="Amundadottir L" first="Laufey T." last="Amundadottir">Laufey T. Amundadottir</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25086665</idno><idno type="pmc">4191666</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191666</idno><idno type="RBID">PMC:4191666</idno><idno type="doi">10.1038/ng.3052</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002E35</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E35</idno><idno type="wicri:Area/Pmc/Curation">002C85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer</title><author><name sortKey="Wolpin, Brian M" sort="Wolpin, Brian M" uniqKey="Wolpin B" first="Brian M." last="Wolpin">Brian M. Wolpin</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Rizzato, Cosmeri" sort="Rizzato, Cosmeri" uniqKey="Rizzato C" first="Cosmeri" last="Rizzato">Cosmeri Rizzato</name><affiliation wicri:level="1"><nlm:aff id="A3">Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="1"><nlm:aff id="A6">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, Gloria M" sort="Petersen, Gloria M" uniqKey="Petersen G" first="Gloria M." last="Petersen">Gloria M. Petersen</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Arslan, Alan A" sort="Arslan, Alan A" uniqKey="Arslan A" first="Alan A." last="Arslan">Alan A. Arslan</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Medicine, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">New York University Cancer Institute, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York University Cancer Institute, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Beane Freeman, Laura" sort="Beane Freeman, Laura" uniqKey="Beane Freeman L" first="Laura" last="Beane-Freeman">Laura Beane-Freeman</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M." last="Bracci">Paige M. Bracci</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Buring, Julie" sort="Buring, Julie" uniqKey="Buring J" first="Julie" last="Buring">Julie Buring</name><affiliation wicri:level="1"><nlm:aff id="A14">Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:aff id="A3">Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J." last="Duell">Eric J. Duell</name><affiliation wicri:level="1"><nlm:aff id="A16">Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:aff id="A17">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="A18">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E." last="Goodman">Gary E. Goodman</name><affiliation wicri:level="1"><nlm:aff id="A6">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Goodman, Phyllis J" sort="Goodman, Phyllis J" uniqKey="Goodman P" first="Phyllis J." last="Goodman">Phyllis J. Goodman</name><affiliation wicri:level="1"><nlm:aff id="A21">Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><affiliation wicri:level="1"><nlm:aff id="A22">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Kamineni, Aruna" sort="Kamineni, Aruna" uniqKey="Kamineni A" first="Aruna" last="Kamineni">Aruna Kamineni</name><affiliation wicri:level="1"><nlm:aff id="A23">Group Health Research Institute, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Alison P" sort="Klein, Alison P" uniqKey="Klein A" first="Alison P." last="Klein">Alison P. Klein</name><affiliation wicri:level="1"><nlm:aff id="A24">Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:aff id="A26">The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Kulke, Matthew H" sort="Kulke, Matthew H" uniqKey="Kulke M" first="Matthew H." last="Kulke">Matthew H. Kulke</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Li, Donghui" sort="Li, Donghui" uniqKey="Li D" first="Donghui" last="Li">Donghui Li</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation wicri:level="1"><nlm:aff id="A28">Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H." last="Olson">Sara H. Olson</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut</wicri:regionArea></affiliation></author><author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D." last="Sesso">Howard D. Sesso</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><affiliation wicri:level="1"><nlm:aff id="A31">Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="A32">Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A34">Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Austin, Melissa A" sort="Austin, Melissa A" uniqKey="Austin M" first="Melissa A." last="Austin">Melissa A. Austin</name><affiliation wicri:level="1"><nlm:aff id="A33">Department of Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Barfield, Richard" sort="Barfield, Richard" uniqKey="Barfield R" first="Richard" last="Barfield">Richard Barfield</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Basso, Daniela" sort="Basso, Daniela" uniqKey="Basso D" first="Daniela" last="Basso">Daniela Basso</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padua</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="1"><nlm:aff id="A37">Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health Team, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health Team, F-94805, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">University Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris Sud, UMRS 1018, F-94805, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">IGR, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IGR, F-94805, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Brotzman, Michelle" sort="Brotzman, Michelle" uniqKey="Brotzman M" first="Michelle" last="Brotzman">Michelle Brotzman</name><affiliation wicri:level="1"><nlm:aff id="A40">Westat, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Westat, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W." last="Büchler">Markus W. Büchler</name><affiliation wicri:level="1"><nlm:aff id="A41">Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="A42">National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A43">Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute of Transfusion Medicine and Immunology, Heidelberg University, Medical Faculty Mannheim, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Transfusion Medicine and Immunology, Heidelberg University, Medical Faculty Mannheim, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim</wicri:regionArea></affiliation></author><author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation wicri:level="1"><nlm:aff id="A46">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E." last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Capurso, Gabriele" sort="Capurso, Gabriele" uniqKey="Capurso G" first="Gabriele" last="Capurso">Gabriele Capurso</name><affiliation wicri:level="1"><nlm:aff id="A47">Digestive and Liver Disease Unit, ‘Sapienza’ University of Rome, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Digestive and Liver Disease Unit, ‘Sapienza’ University of Rome, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Charles" sort="Chung, Charles" uniqKey="Chung C" first="Charles" last="Chung">Charles Chung</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation wicri:level="1"><nlm:aff id="A48">Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Care Ontario, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A49">Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name><affiliation wicri:level="1"><nlm:aff id="A50">National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Elena, Joanne" sort="Elena, Joanne" uniqKey="Elena J" first="Joanne" last="Elena">Joanne Elena</name><affiliation wicri:level="1"><nlm:aff id="A51">Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Funel, Niccola" sort="Funel, Niccola" uniqKey="Funel N" first="Niccola" last="Funel">Niccola Funel</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J. Michael" last="Gaziano">J. Michael Gaziano</name><affiliation wicri:level="1"><nlm:aff id="A14">Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Massachusetts Veteran’s Epidemiology, Research, and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts Veteran’s Epidemiology, Research, and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A." last="Giese">Nathalia A. Giese</name><affiliation wicri:level="1"><nlm:aff id="A41">Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Goggins, Michael" sort="Goggins, Michael" uniqKey="Goggins M" first="Michael" last="Goggins">Michael Goggins</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Gorman, Megan J" sort="Gorman, Megan J" uniqKey="Gorman M" first="Megan J." last="Gorman">Megan J. Gorman</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Gross, Myron" sort="Gross, Myron" uniqKey="Gross M" first="Myron" last="Gross">Myron Gross</name><affiliation wicri:level="1"><nlm:aff id="A59">Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="A60">Preventive Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Preventive Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Hassan, Manal" sort="Hassan, Manal" uniqKey="Hassan M" first="Manal" last="Hassan">Manal Hassan</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J." last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation wicri:level="1"><nlm:aff id="A61">Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="A62">Cancer Prevention, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A." last="Holly">Elizabeth A. Holly</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Nan" sort="Hu, Nan" uniqKey="Hu N" first="Nan" last="Hu">Nan Hu</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A63">Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A64">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Innocenti, Federico" sort="Innocenti, Federico" uniqKey="Innocenti F" first="Federico" last="Innocenti">Federico Innocenti</name><affiliation wicri:level="1"><nlm:aff id="A65">The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation wicri:level="1"><nlm:aff id="A66">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="1"><nlm:aff id="A46">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J." last="Key">Timothy J. Key</name><affiliation wicri:level="1"><nlm:aff id="A67">Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A68">School of Clinical Medicine, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Medicine, University of Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Eric A" sort="Klein, Eric A" uniqKey="Klein E" first="Eric A." last="Klein">Eric A. Klein</name><affiliation wicri:level="1"><nlm:aff id="A69">Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:aff id="A70">Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar Institute of Medical Research (IMIM), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">National School of Public Health, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>National School of Public Health, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="1"><nlm:aff id="A73">Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Kupcinskas, Juozas" sort="Kupcinskas, Juozas" uniqKey="Kupcinskas J" first="Juozas" last="Kupcinskas">Juozas Kupcinskas</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas</wicri:regionArea></affiliation></author><author><name sortKey="Kurtz, Robert C" sort="Kurtz, Robert C" uniqKey="Kurtz R" first="Robert C." last="Kurtz">Robert C. Kurtz</name><affiliation wicri:level="1"><nlm:aff id="A75">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation wicri:level="1"><nlm:aff id="A6">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T." last="Landi">Maria T. Landi</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Landi, Stefano" sort="Landi, Stefano" uniqKey="Landi S" first="Stefano" last="Landi">Stefano Landi</name><affiliation wicri:level="1"><nlm:aff id="A76">Department of Biology, University of Pisa, Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea></affiliation></author><author><name sortKey="Mambrini, Andrea" sort="Mambrini, Andrea" uniqKey="Mambrini A" first="Andrea" last="Mambrini">Andrea Mambrini</name><affiliation wicri:level="1"><nlm:aff id="A78">Oncology Department, ASL1 Massa Carrara, Massa Carrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Oncology Department, ASL1 Massa Carrara, Massa Carrara</wicri:regionArea></affiliation></author><author><name sortKey="Mannisto, Satu" sort="Mannisto, Satu" uniqKey="Mannisto S" first="Satu" last="Mannisto">Satu Mannisto</name><affiliation wicri:level="1"><nlm:aff id="A79">National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="A18">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation wicri:level="1"><nlm:aff id="A80">Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L." last="Oberg">Ann L. Oberg</name><affiliation wicri:level="1"><nlm:aff id="A81">Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Owzar, Kouros" sort="Owzar, Kouros" uniqKey="Owzar K" first="Kouros" last="Owzar">Kouros Owzar</name><affiliation wicri:level="1"><nlm:aff id="A82">Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V." last="Patel">Alpa V. Patel</name><affiliation wicri:level="1"><nlm:aff id="A22">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H. M." last="Peeters">Petra H. M. Peeters</name><affiliation wicri:level="1"><nlm:aff id="A83">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A84">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A85">Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Pezzilli, Raffaele" sort="Pezzilli, Raffaele" uniqKey="Pezzilli R" first="Raffaele" last="Pezzilli">Raffaele Pezzilli</name><affiliation wicri:level="1"><nlm:aff id="A86">Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital, Bologna</wicri:regionArea></affiliation></author><author><name sortKey="Piepoli, Ada" sort="Piepoli, Ada" uniqKey="Piepoli A" first="Ada" last="Piepoli">Ada Piepoli</name><affiliation wicri:level="1"><nlm:aff id="A87">Department of Gastroenterology, Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gastroenterology, Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo</wicri:regionArea></affiliation></author><author><name sortKey="Porta, Miquel" sort="Porta, Miquel" uniqKey="Porta M" first="Miquel" last="Porta">Miquel Porta</name><affiliation wicri:level="1"><nlm:aff id="A71">Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar Institute of Medical Research (IMIM), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">School of Medicine, Universitat Autònoma de Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>School of Medicine, Universitat Autònoma de Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A89">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea></affiliation></author><author><name sortKey="Real, Francisco X" sort="Real, Francisco X" uniqKey="Real F" first="Francisco X." last="Real">Francisco X. Real</name><affiliation wicri:level="1"><nlm:aff id="A90">Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="1"><nlm:aff id="A44">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name><affiliation wicri:level="1"><nlm:aff id="A92">ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona</wicri:regionArea></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A34">Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T." last="Silverman">Debra T. Silverman</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Soucek, Pavel" sort="Soucek, Pavel" uniqKey="Soucek P" first="Pavel" last="Soucek">Pavel Soucek</name><affiliation wicri:level="1"><nlm:aff id="A93">Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Surgical and Peroperative Sciences, Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical and Peroperative Sciences, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Talar Wojnarowska, Renata" sort="Talar Wojnarowska, Renata" uniqKey="Talar Wojnarowska R" first="Renata" last="Talar-Wojnarowska">Renata Talar-Wojnarowska</name><affiliation wicri:level="1"><nlm:aff id="A95">Department of Digestive Tract Diseases, Medical University of Łodz, Łodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz</wicri:regionArea></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Theodoropoulos, George E" sort="Theodoropoulos, George E" uniqKey="Theodoropoulos G" first="George E." last="Theodoropoulos">George E. Theodoropoulos</name><affiliation wicri:level="1"><nlm:aff id="A96">1st Propaideutic Surgical Department, Hippocration University Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Propaideutic Surgical Department, Hippocration University Hospital, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><affiliation wicri:level="1"><nlm:aff id="A6">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="1"><nlm:aff id="A97">Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Tobias, Geoffrey S" sort="Tobias, Geoffrey S" uniqKey="Tobias G" first="Geoffrey S." last="Tobias">Geoffrey S. Tobias</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A98">Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Bureau of Epidemiologic Research, Academy of Athens, Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A99">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Vodicka, Pavel" sort="Vodicka, Pavel" uniqKey="Vodicka P" first="Pavel" last="Vodicka">Pavel Vodicka</name><affiliation wicri:level="1"><nlm:aff id="A100">Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation wicri:level="1"><nlm:aff id="A101">Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York</wicri:regionArea></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Chen" sort="Wu, Chen" uniqKey="Wu C" first="Chen" last="Wu">Chen Wu</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><affiliation wicri:level="1"><nlm:aff id="A77">Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Medicine, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">New York University Cancer Institute, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York University Cancer Institute, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Fuchs, Charles" sort="Fuchs, Charles" uniqKey="Fuchs C" first="Charles" last="Fuchs">Charles Fuchs</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Stolzenberg Solomon, Rachael S" sort="Stolzenberg Solomon, Rachael S" uniqKey="Stolzenberg Solomon R" first="Rachael S." last="Stolzenberg-Solomon">Rachael S. Stolzenberg-Solomon</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Amundadottir, Laufey T" sort="Amundadottir, Laufey T" uniqKey="Amundadottir L" first="Laufey T." last="Amundadottir">Laufey T. Amundadottir</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (<italic>LINC-PINT</italic>; per-allele odds ratio [OR] = 0.79; 95% confidence interval [CI] = 0.74–0.84; <italic>P</italic> = 3.0×10<sup>−12</sup>), rs7190458 at 16q23.1 (<italic>BCAR1/CTRB1/CTRB2</italic>; OR = 1.46; 95% CI = 1.30–1.65; <italic>P</italic> = 1.1×10<sup>−10</sup>), rs9581943 at 13q12.2 (<italic>PDX1</italic>; OR = 1.15; 95% CI = 1.10–1.20; <italic>P</italic> = 2.4×10<sup>−9</sup>), and rs16986825 at 22q12.1 (<italic>ZNRF3</italic>; OR = 1.18; 95% CI = 1.12–1.25; <italic>P</italic> = 1.2×10<sup>−8</sup>). An independent signal was identified in exon 2 of <italic>TERT</italic> at the established region 5p15.33 (rs2736098; OR = 0.80; 95% CI = 0.76–0.85; <italic>P</italic> = 9.8×10<sup>−14</sup>). We also identified a locus at 8q24.21 (rs1561927; <italic>P</italic> = 1.3×10<sup>−7</sup>) that approached genome-wide significance located 455 kb telomeric of <italic>PVT1</italic>. 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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25086665</article-id><article-id pub-id-type="pmc">4191666</article-id><article-id pub-id-type="doi">10.1038/ng.3052</article-id><article-id pub-id-type="manuscript">NIHMS612903</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wolpin</surname><given-names>Brian M.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib 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rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Herbert</given-names></name><xref ref-type="aff" rid="A77">77</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Kai</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Zeleniuch-Jacquotte</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Hoover</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Hartge</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><contrib contrib-type="author"><name><surname>Fuchs</surname><given-names>Charles</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A54">54</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Stolzenberg-Solomon</surname><given-names>Rachael S.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Amundadottir</surname><given-names>Laufey T.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A2"><label>2</label>Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A3"><label>3</label>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A4"><label>4</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A5"><label>5</label>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A6"><label>6</label>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</aff><aff id="A7"><label>7</label>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A8"><label>8</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A9"><label>9</label>Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</aff><aff id="A10"><label>10</label>Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA</aff><aff id="A11"><label>11</label>Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA</aff><aff id="A12"><label>12</label>New York University Cancer Institute, New York, New York, USA</aff><aff id="A13"><label>13</label>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA</aff><aff id="A14"><label>14</label>Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A15"><label>15</label>Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A16"><label>16</label>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain</aff><aff id="A17"><label>17</label>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</aff><aff id="A18"><label>18</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</aff><aff id="A19"><label>19</label>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia</aff><aff id="A20"><label>20</label>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia</aff><aff id="A21"><label>21</label>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</aff><aff id="A22"><label>22</label>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</aff><aff id="A23"><label>23</label>Group Health Research Institute, Seattle, Washington, USA</aff><aff id="A24"><label>24</label>Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</aff><aff id="A25"><label>25</label>Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland, USA</aff><aff id="A26"><label>26</label>The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii, USA</aff><aff id="A27"><label>27</label>Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</aff><aff id="A28"><label>28</label>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="A29"><label>29</label>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</aff><aff id="A30"><label>30</label>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA</aff><aff id="A31"><label>31</label>Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</aff><aff id="A32"><label>32</label>Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</aff><aff id="A33"><label>33</label>Department of Epidemiology, University of Washington, Seattle, Washington, USA</aff><aff id="A34"><label>34</label>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA</aff><aff id="A35"><label>35</label>Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA</aff><aff id="A36"><label>36</label>Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy</aff><aff id="A37"><label>37</label>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health Team, F-94805, Villejuif, France</aff><aff id="A38"><label>38</label>University Paris Sud, UMRS 1018, F-94805, Villejuif, France</aff><aff id="A39"><label>39</label>IGR, F-94805, Villejuif, France</aff><aff id="A40"><label>40</label>Westat, Rockville, Maryland, USA</aff><aff id="A41"><label>41</label>Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany</aff><aff id="A42"><label>42</label>National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</aff><aff id="A43"><label>43</label>Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands</aff><aff id="A44"><label>44</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</aff><aff id="A45"><label>45</label>Institute of Transfusion Medicine and Immunology, Heidelberg University, Medical Faculty Mannheim, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim, Germany</aff><aff id="A46"><label>46</label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A47"><label>47</label>Digestive and Liver Disease Unit, ‘Sapienza’ University of Rome, Rome, Italy</aff><aff id="A48"><label>48</label>Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A49"><label>49</label>Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A50"><label>50</label>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom</aff><aff id="A51"><label>51</label>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A52"><label>52</label>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy</aff><aff id="A53"><label>53</label>Massachusetts Veteran’s Epidemiology, Research, and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA</aff><aff id="A54"><label>54</label>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A55"><label>55</label>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A56"><label>56</label>Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</aff><aff id="A57"><label>57</label>Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</aff><aff id="A58"><label>58</label>Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA</aff><aff id="A59"><label>59</label>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA</aff><aff id="A60"><label>60</label>Preventive Medicine, University of Southern California, Los Angeles, California, USA</aff><aff id="A61"><label>61</label>Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, USA</aff><aff id="A62"><label>62</label>Cancer Prevention, University of Southern California, Los Angeles, California, USA</aff><aff id="A63"><label>63</label>Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A64"><label>64</label>Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A65"><label>65</label>The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina, USA</aff><aff id="A66"><label>66</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="A67"><label>67</label>Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom</aff><aff id="A68"><label>68</label>School of Clinical Medicine, University of Cambridge, United Kingdom</aff><aff id="A69"><label>69</label>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA</aff><aff id="A70"><label>70</label>Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Spain</aff><aff id="A71"><label>71</label>Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain</aff><aff id="A72"><label>72</label>National School of Public Health, Athens, Greece</aff><aff id="A73"><label>73</label>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</aff><aff id="A74"><label>74</label>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania</aff><aff id="A75"><label>75</label>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</aff><aff id="A76"><label>76</label>Department of Biology, University of Pisa, Pisa, Italy</aff><aff id="A77"><label>77</label>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA</aff><aff id="A78"><label>78</label>Oncology Department, ASL1 Massa Carrara, Massa Carrara, Italy</aff><aff id="A79"><label>79</label>National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland</aff><aff id="A80"><label>80</label>Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</aff><aff id="A81"><label>81</label>Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A82"><label>82</label>Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA</aff><aff id="A83"><label>83</label>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A84"><label>84</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</aff><aff id="A85"><label>85</label>Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</aff><aff id="A86"><label>86</label>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital, Bologna, Italy</aff><aff id="A87"><label>87</label>Department of Gastroenterology, Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, Italy</aff><aff id="A88"><label>88</label>School of Medicine, Universitat Autònoma de Barcelona, Spain</aff><aff id="A89"><label>89</label>CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</aff><aff id="A90"><label>90</label>Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="A91"><label>91</label>Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain</aff><aff id="A92"><label>92</label>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy</aff><aff id="A93"><label>93</label>Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague, Czech Republic</aff><aff id="A94"><label>94</label>Department of Surgical and Peroperative Sciences, Umeå University, Umeå, Sweden</aff><aff id="A95"><label>95</label>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz, Poland</aff><aff id="A96"><label>96</label>1st Propaideutic Surgical Department, Hippocration University Hospital, Athens, Greece</aff><aff id="A97"><label>97</label>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark</aff><aff id="A98"><label>98</label>Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</aff><aff id="A99"><label>99</label>Hellenic Health Foundation, Athens, Greece</aff><aff id="A100"><label>100</label>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</aff><aff id="A101"><label>101</label>Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York, USA</aff><author-notes><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">These authors contributed equally to this work</p></fn><fn id="FN2"><label>†</label><p id="P2">These authors jointly directed this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>03</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2015</year></pub-date><volume>46</volume><issue>9</issue><fpage>994</fpage><lpage>1000</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.3052</pmc-comment>
<permissions><license xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms"><license-p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link></license-p></license></permissions><abstract><p id="P3">We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (<italic>LINC-PINT</italic>; per-allele odds ratio [OR] = 0.79; 95% confidence interval [CI] = 0.74–0.84; <italic>P</italic> = 3.0×10<sup>−12</sup>), rs7190458 at 16q23.1 (<italic>BCAR1/CTRB1/CTRB2</italic>; OR = 1.46; 95% CI = 1.30–1.65; <italic>P</italic> = 1.1×10<sup>−10</sup>), rs9581943 at 13q12.2 (<italic>PDX1</italic>; OR = 1.15; 95% CI = 1.10–1.20; <italic>P</italic> = 2.4×10<sup>−9</sup>), and rs16986825 at 22q12.1 (<italic>ZNRF3</italic>; OR = 1.18; 95% CI = 1.12–1.25; <italic>P</italic> = 1.2×10<sup>−8</sup>). An independent signal was identified in exon 2 of <italic>TERT</italic> at the established region 5p15.33 (rs2736098; OR = 0.80; 95% CI = 0.76–0.85; <italic>P</italic> = 9.8×10<sup>−14</sup>). We also identified a locus at 8q24.21 (rs1561927; <italic>P</italic> = 1.3×10<sup>−7</sup>) that approached genome-wide significance located 455 kb telomeric of <italic>PVT1</italic>. Our study has identified multiple new susceptibility alleles for pancreatic cancer worthy of follow-up studies.</p></abstract></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><title>Association results, recombination hotspots and LD plots for new pancreatic cancer susceptibility regions (a–e) and one suggestive region (f)</title><p id="P37">Top, association results of GWAS data from the stage 1 (gray diamonds), stage 2 (purple diamonds), replication (blue diamonds) and the combined data from stages 1–3 (red diamonds) plotted against −log<sub>10</sub><italic>P</italic> values (left y axis). Overlaid are likelihood ratio statistics (right y axis) estimating putative recombination hotspots across the region on the basis of five unique sets of 100 randomly selected control samples. Bottom, LD heat map based on r<sup>2</sup> values from the total control populations for all SNPs included in the GWAS. The data are based on a total number of 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Shown are results for 5p15.33 (a), 7q32.3 (b), 16q23.1 (c), 13q12.2 (d), 22q12.1 (e), and 8q24.1 (f).</p></caption><graphic xlink:href="nihms612903f1a"></graphic><graphic xlink:href="nihms612903f1b"></graphic><graphic xlink:href="nihms612903f1c"></graphic><graphic xlink:href="nihms612903f1d"></graphic><graphic xlink:href="nihms612903f1e"></graphic><graphic xlink:href="nihms612903f1f"></graphic></fig><table-wrap id="T1" position="float" orientation="portrait"><label>Table 1</label><caption><p id="P38">Subject numbers and characteristics of pancreatic cancer cases and controls</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">Cases<break></break>No. (%)</th><th align="center" rowspan="1" colspan="1">Controls<break></break>No. (%)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>No. of subjects</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Stage 1</td><td align="center" rowspan="1" colspan="1">1,582</td><td align="center" rowspan="1" colspan="1">5,203</td></tr><tr><td align="left" rowspan="1" colspan="1"> Stage 2</td><td align="center" rowspan="1" colspan="1">3,525</td><td align="center" rowspan="1" colspan="1">3,642</td></tr><tr><td align="left" rowspan="1" colspan="1"> Replication</td><td align="center" rowspan="1" colspan="1">2,576</td><td align="center" rowspan="1" colspan="1">5,552</td></tr><tr><td align="left" rowspan="1" colspan="1"> Full study population</td><td align="center" rowspan="1" colspan="1">7,683</td><td align="center" rowspan="1" colspan="1">14,397</td></tr><tr><td align="center" colspan="3" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Geographic region</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> United States</td><td align="center" rowspan="1" colspan="1">4,387 (57.1)</td><td align="center" rowspan="1" colspan="1">7,962 (55.3)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Central/Northern Europe</td><td align="center" rowspan="1" colspan="1">2,264 (29.5)</td><td align="center" rowspan="1" colspan="1">3,853 (26.8)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Southern Europe</td><td align="center" rowspan="1" colspan="1">1,032 (13.4)</td><td align="center" rowspan="1" colspan="1">2,582 (17.9)</td></tr><tr><td align="center" colspan="3" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Sex</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">4,107 (53.5)</td><td align="center" rowspan="1" colspan="1">8,841 (61.4)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">3,576 (46.5)</td><td align="center" rowspan="1" colspan="1">5,556 (38.6)</td></tr><tr><td align="center" colspan="3" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Age, years</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> ≤ 60</td><td align="center" rowspan="1" colspan="1">1,972 (25.7)</td><td align="center" rowspan="1" colspan="1">4,577 (31.8)</td></tr><tr><td align="left" rowspan="1" colspan="1"> 61 – 70</td><td align="center" rowspan="1" colspan="1">2,688 (35.0)</td><td align="center" rowspan="1" colspan="1">5,906 (41.0)</td></tr><tr><td align="left" rowspan="1" colspan="1"> > 70</td><td align="center" rowspan="1" colspan="1">3,023 (39.3)</td><td align="center" rowspan="1" colspan="1">3,914 (27.2)</td></tr><tr><td align="center" colspan="3" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Smoking status</bold><xref ref-type="table-fn" rid="TFN1">*</xref></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> Current / past</td><td align="center" rowspan="1" colspan="1">2,634 (51.6)</td><td align="center" rowspan="1" colspan="1">4,541 (51.3)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Never</td><td align="center" rowspan="1" colspan="1">1,642 (32.2)</td><td align="center" rowspan="1" colspan="1">3,186 (36.0)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Unknown</td><td align="center" rowspan="1" colspan="1">831 (16.3)</td><td align="center" rowspan="1" colspan="1">1,118 (12.6)</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>*</label><p id="P39">Smoking status was available for subjects in Stages 1 and 2.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float" orientation="landscape"><label>Table 2</label><caption><p id="P40">Association results for five new pancreatic cancer susceptibility loci and one suggestive locus</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="3" valign="middle" colspan="1">Chr</th><th align="left" rowspan="3" valign="middle" colspan="1">Nearest gene(s)<xref ref-type="table-fn" rid="TFN3">a</xref></th><th align="center" rowspan="3" valign="middle" colspan="1">SNP</th><th align="center" rowspan="3" valign="middle" colspan="1">Position<xref ref-type="table-fn" rid="TFN4">b</xref></th><th align="center" rowspan="3" valign="middle" colspan="1">Minor<break></break>allele<xref ref-type="table-fn" rid="TFN5">c</xref></th><th align="center" rowspan="3" valign="middle" colspan="1">Major<break></break>allele<xref ref-type="table-fn" rid="TFN5">c</xref></th><th align="left" rowspan="3" valign="middle" colspan="1">Stage</th><th align="center" rowspan="3" valign="middle" colspan="1">Allelic OR<break></break>(95% CI)</th><th align="center" colspan="2" valign="middle" rowspan="1">Minor allele<break></break>frequency</th><th align="center" rowspan="3" valign="middle" colspan="1"><italic>P</italic><xref ref-type="table-fn" rid="TFN8">f</xref></th></tr><tr><th align="center" colspan="2" valign="bottom" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="middle" rowspan="1" colspan="1">Controls</th><th align="center" valign="middle" rowspan="1" colspan="1">Cases</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">5p15.33</td><td align="left" rowspan="1" colspan="1"><italic>TERT, MIR4457, CLPTM1L</italic></td><td align="center" rowspan="1" colspan="1">rs2736098</td><td align="center" rowspan="1" colspan="1">1,294,086</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">C</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="center" rowspan="1" colspan="1">0.76 (0.68–0.86)</td><td align="center" rowspan="1" colspan="1">0.268</td><td align="center" rowspan="1" colspan="1">0.216</td><td align="center" rowspan="1" colspan="1">8.22 × 10<sup>−6</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="center" rowspan="1" colspan="1">0.82 (0.74–0.90)</td><td align="center" rowspan="1" colspan="1">0.284</td><td align="center" rowspan="1" colspan="1">0.259</td><td align="center" rowspan="1" colspan="1">2.63 × 10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Replication<xref ref-type="table-fn" rid="TFN6">d</xref></td><td align="center" rowspan="1" colspan="1">0.81 (0.74–0.89)</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">1.36 × 10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold>Combined</bold><xref ref-type="table-fn" rid="TFN7">e</xref></td><td align="center" rowspan="1" colspan="1"><bold>0.80 (0.76–0.85)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><bold>9.78 × 10<sup>−14</sup></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">7q32.3</td><td align="left" rowspan="1" colspan="1"><italic>LINC-PINT</italic></td><td align="center" rowspan="1" colspan="1">rs6971499</td><td align="center" rowspan="1" colspan="1">130,680,521</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">T</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="center" rowspan="1" colspan="1">0.79 (0.68–0.90)</td><td align="center" rowspan="1" colspan="1">0.155</td><td align="center" rowspan="1" colspan="1">0.127</td><td align="center" rowspan="1" colspan="1">6.58 × 10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="center" rowspan="1" colspan="1">0.81 (0.74–0.90)</td><td align="center" rowspan="1" colspan="1">0.147</td><td align="center" rowspan="1" colspan="1">0.124</td><td align="center" rowspan="1" colspan="1">4.69 × 10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Replication<xref ref-type="table-fn" rid="TFN6">d</xref></td><td align="center" rowspan="1" colspan="1">0.77 (0.69–0.86)</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">4.37 × 10<sup>−6</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold>Combined</bold><xref ref-type="table-fn" rid="TFN7">e</xref></td><td align="center" rowspan="1" colspan="1"><bold>0.79 (0.74–0.84)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><bold>2.98 × 10<sup>−12</sup></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">16q23.1</td><td align="left" rowspan="1" colspan="1"><italic>BCAR1, CTRB1, CTRB2</italic></td><td align="center" rowspan="1" colspan="1">rs7190458</td><td align="center" rowspan="1" colspan="1">75,263,661</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">G</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="center" rowspan="1" colspan="1">1.61 (1.32–1.96)</td><td align="center" rowspan="1" colspan="1">0.042</td><td align="center" rowspan="1" colspan="1">0.065</td><td align="center" rowspan="1" colspan="1">4.14 × 10<sup>−6</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="center" rowspan="1" colspan="1">1.47 (1.20–1.82)</td><td align="center" rowspan="1" colspan="1">0.039</td><td align="center" rowspan="1" colspan="1">0.049</td><td align="center" rowspan="1" colspan="1">2.17 × 10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Replication<xref ref-type="table-fn" rid="TFN6">d</xref></td><td align="center" rowspan="1" colspan="1">1.33 (1.10–1.61)</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">3.14 × 10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold>Combined</bold><xref ref-type="table-fn" rid="TFN7">e</xref></td><td align="center" rowspan="1" colspan="1"><bold>1.46 (1.30–1.65)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><bold>1.13 × 10<sup>−10</sup></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">13q12.2</td><td align="left" rowspan="1" colspan="1"><italic>PDX1</italic></td><td align="center" rowspan="1" colspan="1">rs9581943</td><td align="center" rowspan="1" colspan="1">28,493,997</td><td align="center" rowspan="1" colspan="1">A</td><td align="center" rowspan="1" colspan="1">G</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="center" rowspan="1" colspan="1">1.23 (1.12–1.35)</td><td align="center" rowspan="1" colspan="1">0.397</td><td align="center" rowspan="1" colspan="1">0.441</td><td align="center" rowspan="1" colspan="1">1.34 × 10<sup>−5</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="center" rowspan="1" colspan="1">1.12 (1.05–1.20)</td><td align="center" rowspan="1" colspan="1">0.406</td><td align="center" rowspan="1" colspan="1">0.434</td><td align="center" rowspan="1" colspan="1">5.51 × 10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Replication<xref ref-type="table-fn" rid="TFN6">d</xref></td><td align="center" rowspan="1" colspan="1">1.11 (1.03–1.20)</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">4.80 × 10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold>Combined</bold><xref ref-type="table-fn" rid="TFN7">e</xref></td><td align="center" rowspan="1" colspan="1"><bold>1.15 (1.10–1.20)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><bold>2.35 × 10<sup>−9</sup></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">22q12.1</td><td align="left" rowspan="1" colspan="1"><italic>ZNRF3</italic></td><td align="center" rowspan="1" colspan="1">rs16986825</td><td align="center" rowspan="1" colspan="1">29,300,306</td><td align="center" rowspan="1" colspan="1">T</td><td align="center" rowspan="1" colspan="1">C</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="center" rowspan="1" colspan="1">1.25 (1.10–1.42)</td><td align="center" rowspan="1" colspan="1">0.150</td><td align="center" rowspan="1" colspan="1">0.184</td><td align="center" rowspan="1" colspan="1">4.96 × 10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="center" rowspan="1" colspan="1">1.15 (1.05–1.26)</td><td align="center" rowspan="1" colspan="1">0.149</td><td align="center" rowspan="1" colspan="1">0.168</td><td align="center" rowspan="1" colspan="1">2.11 × 10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Replication<xref ref-type="table-fn" rid="TFN6">d</xref></td><td align="center" rowspan="1" colspan="1">1.18 (1.08–1.30)</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">5.13 × 10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold>Combined</bold><xref ref-type="table-fn" rid="TFN7">e</xref></td><td align="center" rowspan="1" colspan="1"><bold>1.18 (1.12–1.25)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><bold>1.18 × 10<sup>−8</sup></bold></td></tr><tr><td align="left" rowspan="1" colspan="1">8q24.21</td><td align="left" rowspan="1" colspan="1"><italic>MIR1208, PVT1</italic></td><td align="center" rowspan="1" colspan="1">rs1561927</td><td align="center" rowspan="1" colspan="1">129,568,078</td><td align="center" rowspan="1" colspan="1">C</td><td align="center" rowspan="1" colspan="1">T</td><td align="left" rowspan="1" colspan="1">Stage 1</td><td align="center" rowspan="1" colspan="1">0.88 (0.78–0.97)</td><td align="center" rowspan="1" colspan="1">0.269</td><td align="center" rowspan="1" colspan="1">0.251</td><td align="center" rowspan="1" colspan="1">1.59 × 10<sup>−2</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Stage 2</td><td align="center" rowspan="1" colspan="1">0.86 (0.80–0.93)</td><td align="center" rowspan="1" colspan="1">0.279</td><td align="center" rowspan="1" colspan="1">0.250</td><td align="center" rowspan="1" colspan="1">1.11 × 10<sup>−4</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Replication<xref ref-type="table-fn" rid="TFN6">d</xref></td><td align="center" rowspan="1" colspan="1">0.89 (0.82–0.97)</td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">6.44 × 10<sup>−3</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><bold>Combined</bold><xref ref-type="table-fn" rid="TFN7">e</xref></td><td align="center" rowspan="1" colspan="1"><bold>0.87 (0.83–0.92)</bold></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1"><bold>1.30 × 10<sup>−7</sup></bold></td></tr></tbody></table><table-wrap-foot><fn id="TFN2"><p id="P41">Results from unconditional logistic regression of the genotypes generated in Stage 1, Stage 2, and replication (total of 7,683 individuals diagnosed with pancreatic cancer and 14,397 controls).</p></fn><fn id="TFN3"><label>a</label><p id="P42">Closest RefSeq gene(s). Genes located within 25 kb of SNP are listed in black in order of closest gene to those further away; closest genes outside this 50 kb window are listed in grey.</p></fn><fn id="TFN4"><label>b</label><p id="P43">Position of SNP in NCBI genome build 37 (Hg19).</p></fn><fn id="TFN5"><label>c</label><p id="P44">Minor and major alleles.</p></fn><fn id="TFN6"><label>d</label><p id="P45">The replication is a meta-analysis of three groups and thus, minor allele frequency (MAF) is not listed.</p></fn><fn id="TFN7"><label>e</label><p id="P46">Number of case and control subjects in joint analysis of Stage 1, Stage 2 and replication: rs2736098 (7,199/13,121), rs6971499 (7,435/13,289), rs7190458 (7,412/13,291), rs9581943 (7,415/13,286), rs16986825 (7,413/13,196), rs1561927 (7,486/13,274).</p></fn><fn id="TFN8"><label>f</label><p id="P47">1 d.f. score test;</p></fn><fn id="TFN9"><p id="P48">Chr: chromosome and band; OR, per-allele OR for the minor allele adjusted for age, sex, geographic region and significant principal components for Stage 1; per-allele OR adjusted for age, sex, study, arm and significant principal components for Stage 2; per-allele OR adjusted for age, sex and study for Replication. Text in bold indicates the combined meta-analysis results.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" position="float" orientation="landscape"><label>Table 3</label><caption><p id="P49">Conditional analyses of SNPs at chromosomes 5p15.33 and 9q34.2</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" rowspan="1" colspan="1">New SNP</th><th align="center" rowspan="1" colspan="1">Chr</th><th align="center" rowspan="1" colspan="1">Position<xref ref-type="table-fn" rid="TFN10">a</xref></th><th align="center" rowspan="1" colspan="1">Gene</th><th align="center" rowspan="1" colspan="1">OR<xref ref-type="table-fn" rid="TFN11">b</xref></th><th align="center" rowspan="1" colspan="1"><italic>P</italic><xref ref-type="table-fn" rid="TFN11">b</xref></th><th align="center" rowspan="1" colspan="1">Conditional OR<xref ref-type="table-fn" rid="TFN12">c</xref></th><th align="center" rowspan="1" colspan="1">Conditional <italic>P</italic><xref ref-type="table-fn" rid="TFN12">c</xref></th><th align="center" rowspan="1" colspan="1">Established SNP</th><th align="center" rowspan="1" colspan="1">r<sup>2</sup>,<xref ref-type="table-fn" rid="TFN13">d</xref></th><th align="center" rowspan="1" colspan="1">OR<xref ref-type="table-fn" rid="TFN14">e</xref></th><th align="center" rowspan="1" colspan="1"><italic>P</italic><xref ref-type="table-fn" rid="TFN14">e</xref></th><th align="center" rowspan="1" colspan="1">Conditonal OR<xref ref-type="table-fn" rid="TFN15">f</xref></th><th align="center" rowspan="1" colspan="1">Conditional <italic>P</italic><xref ref-type="table-fn" rid="TFN15">f</xref></th></tr></thead><tbody><tr><td align="center" rowspan="1" colspan="1">rs2736098</td><td align="center" rowspan="1" colspan="1">5p15.33</td><td align="center" rowspan="1" colspan="1">1,294,086</td><td align="center" rowspan="1" colspan="1"><italic>TERT, CLPTM1L</italic></td><td align="center" rowspan="1" colspan="1">0.80 (0.74–0.86)</td><td align="center" rowspan="1" colspan="1">1.42 × 10<sup>−9</sup></td><td align="center" rowspan="1" colspan="1">0.88 (0.80–0.95)</td><td align="center" rowspan="1" colspan="1">2.44 × 10<sup>−3</sup></td><td align="center" rowspan="1" colspan="1">rs401681 / rs31490</td><td align="center" rowspan="1" colspan="1">0.22</td><td align="center" rowspan="1" colspan="1">0.83 (0.79–0.88)</td><td align="center" rowspan="1" colspan="1">1.97 × 10<sup>−11</sup></td><td align="center" rowspan="1" colspan="1">0.86 (0.81–0.92)</td><td align="center" rowspan="1" colspan="1">7.55 × 10<sup>−6</sup></td></tr><tr><td align="center" rowspan="1" colspan="1">rs4962153</td><td align="center" rowspan="1" colspan="1">9q34.2</td><td align="center" rowspan="1" colspan="1">136,323,754</td><td align="center" rowspan="1" colspan="1"><italic>ADAMTS13, ABO</italic></td><td align="center" rowspan="1" colspan="1">1.20 (1.10–1.30)</td><td align="center" rowspan="1" colspan="1">1.97 × 10<sup>−5</sup></td><td align="center" rowspan="1" colspan="1">1.05 (0.96–1.16)</td><td align="center" rowspan="1" colspan="1">0.28</td><td align="center" rowspan="1" colspan="1">rs505902 / rs687289</td><td align="center" rowspan="1" colspan="1">0.17</td><td align="center" rowspan="1" colspan="1">1.27 (1.20–1.35)</td><td align="center" rowspan="1" colspan="1">1.64 × 10<sup>−16</sup></td><td align="center" rowspan="1" colspan="1">1.25 (1.18–1.33)</td><td align="center" rowspan="1" colspan="1">6.28 × 10<sup>−12</sup></td></tr></tbody></table><table-wrap-foot><fn id="TFN10"><label>a</label><p id="P50">Position of SNP in NCBI genome build 37 (Hg19).</p></fn><fn id="TFN11"><label>b</label><p id="P51">Per-allele ORs for the minor allele and <italic>P</italic> values for the new SNP from the unconditional meta-analysis of Stage 1 and Stage 2.</p></fn><fn id="TFN12"><label>c</label><p id="P52">Per-allele ORs for the minor allele and <italic>P</italic> values for the new SNP from the conditional meta-analysis.</p></fn><fn id="TFN13"><label>d</label><p id="P53">r<sup>2</sup> LD values between the new SNP and the established SNP at the locus based on 1000 Genomes Project CEU data.</p></fn><fn id="TFN14"><label>e</label><p id="P54">Per-allele ORs for the minor allele and <italic>P</italic> values for the established SNP from the unconditional meta-analysis of Stage 1 and Stage 2.</p></fn><fn id="TFN15"><label>f</label><p id="P55">Per-allele ORs for the minor allele and <italic>P</italic> values for the established SNP from the conditional meta-analysis.</p></fn><fn id="TFN16"><p id="P56">Chr: chromosome.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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