Meta-analyses identify 13 novel loci associated with age at menopause and highlights DNA repair and immune pathways
Identifieur interne : 002C61 ( Pmc/Curation ); précédent : 002C60; suivant : 002C62Meta-analyses identify 13 novel loci associated with age at menopause and highlights DNA repair and immune pathways
Auteurs : Lisette Stolk [Pays-Bas] ; John Rb Perry [Royaume-Uni] ; Daniel I. Chasman [États-Unis] ; Chunyan He [États-Unis] ; Massimo Mangino [Royaume-Uni] ; Patrick Sulem [Islande] ; Maja Barbalic [États-Unis] ; Linda Broer [Pays-Bas] ; Enda M. Byrne [Australie] ; Florian Ernst [Allemagne] ; T Nu Esko [Estonie] ; Nora Franceschini [États-Unis] ; Daniel F. Gudbjartsson [Islande] ; Jouke-Jan Hottenga [Pays-Bas] ; Peter Kraft [États-Unis] ; Patick F. Mcardle [États-Unis] ; Eleonora Porcu [Italie] ; So-Youn Shin [Royaume-Uni] ; Albert V. Smith [Islande] ; Sophie Van Wingerden [Pays-Bas] ; Guangju Zhai [Royaume-Uni, Canada] ; Wei V. Zhuang [États-Unis] ; Eva Albrecht [Allemagne] ; Behrooz Z. Alizadeh [Pays-Bas] ; Thor Aspelund [Islande] ; Stefania Bandinelli [Italie] ; Lovorka Barac Lauc [Croatie] ; Jacques S. Beckmann [Suisse] ; Mladen Boban [Croatie] ; Eric Boerwinkle [États-Unis] ; Frank J. Broekmans [Pays-Bas] ; Andrea Burri [Royaume-Uni] ; Harry Campbell [Royaume-Uni] ; Stephen J. Chanock [États-Unis] ; Constance Chen [États-Unis] ; Marilyn C. Cornelis [États-Unis] ; Tanguy Corre [Italie] ; Andrea D. Coviello [États-Unis] ; Pio D Damo [Italie] ; Gail Davies [Royaume-Uni] ; Ulf De Faire [Suède] ; Eco Jc De Geus [Pays-Bas] ; Ian J. Deary [Royaume-Uni] ; George Vz Dedoussis [Grèce] ; Panagiotis Deloukas [Royaume-Uni] ; Shah Ebrahim [Royaume-Uni] ; Gudny Eiriksdottir [Islande] ; Valur Emilsson [Islande] ; Johan G. Eriksson [Finlande] ; Bart Cjm Fauser [Pays-Bas] ; Liana Ferreli [Italie] ; Luigi Ferrucci [États-Unis] ; Krista Fischer [Estonie] ; Aaron R. Folsom [États-Unis] ; Melissa E. Garcia [États-Unis] ; Paolo Gasparini [Italie] ; Christian Gieger [Allemagne] ; Nicole Glazer [États-Unis] ; Diederick E. Grobbee [Pays-Bas] ; Per Hall [Suède] ; Toomas Haller [Estonie] ; Susan E. Hankinson [États-Unis] ; Merli Hass [Estonie] ; Caroline Hayward [Royaume-Uni] ; Andrew C. Heath [États-Unis] ; Albert Hofman [Pays-Bas] ; Erik Ingelsson [Suède] ; A Cecile Jw Janssens [Pays-Bas] ; Andrew D. Johnson [États-Unis] ; David Karasik [États-Unis] ; Sharon Lr Kardia [États-Unis] ; Jules Keyzer [Pays-Bas] ; Douglas P. Kiel [États-Unis] ; Ivana Kolcic [Croatie] ; Zoltán Kutalik [Suisse] ; Jari Lahti [Finlande] ; Sandra Lai [Italie] ; Triin Laisk [Estonie] ; Joop Se Laven [Pays-Bas] ; Debbie A. Lawlor [Royaume-Uni] ; Jianjun Liu [Singapour] ; Lorna M. Lopez [Royaume-Uni] ; Yvonne V. Louwers [Pays-Bas] ; Patrik Ke Magnusson [Suède] ; Mara Marongiu [Italie] ; Nicholas G. Martin [Australie] ; Irena Martinovic Klaric [Croatie] ; Corrado Masciullo [Italie] ; Barbara Mcknight [États-Unis] ; Sarah E. Medland [Australie] ; David Melzer [Royaume-Uni] ; Vincent Mooser [États-Unis] ; Pau Navarro [Royaume-Uni] ; Anne B. Newman [États-Unis] ; Dale R. Nyholt [Australie] ; N. Charlotte Onland-Moret [Pays-Bas] ; Aarno Palotie [Royaume-Uni, Finlande] ; Guillaume Paré [États-Unis, Canada] ; Alex N. Parker [États-Unis] ; Nancy L. Pedersen [Suède] ; Petra Hm Peeters [Pays-Bas, Royaume-Uni] ; Giorgio Pistis [Italie] ; Andrew S. Plump [États-Unis] ; Ozren Polasek [Croatie] ; Victor Jm Pop [Pays-Bas] ; Bruce M. Psaty [États-Unis] ; Katri R Ikkönen [Finlande] ; Emil Rehnberg [Suède] ; Jerome I. Rotter [États-Unis] ; Igor Rudan [Croatie, Royaume-Uni] ; Cinzia Sala [Italie] ; Andres Salumets [Estonie] ; Angelo Scuteri [États-Unis] ; Andrew Singleton [États-Unis] ; Jennifer A. Smith [États-Unis] ; Harold Snieder [Pays-Bas] ; Nicole Soranzo [Royaume-Uni] ; Simon N. Stacey [Islande] ; John M. Starr [Royaume-Uni] ; Maria G. Stathopoulou [Grèce, France] ; Kathleen Stirrups [Royaume-Uni] ; Ronald P. Stolk [Pays-Bas] ; Unnur Styrkarsdottir [Islande] ; Yan V. Sun [États-Unis] ; Albert Tenesa [Royaume-Uni] ; Barbara Thorand [Allemagne] ; Daniela Toniolo [Italie] ; Laufey Tryggvadottir [Islande] ; Kim Tsui [États-Unis] ; Sheila Ulivi [Italie] ; Rob M. Van Dam [États-Unis, Singapour] ; Yvonne T. Van Der Schouw [Pays-Bas] ; Carla H. Van Gils [Pays-Bas] ; Peter Van Nierop [Pays-Bas] ; Jacqueline M. Vink [Pays-Bas] ; Peter M. Visscher [Royaume-Uni, Australie] ; Marlies Voorhuis [Pays-Bas] ; Gérard Waeber [Suisse] ; Henri Wallaschofski ; H Erich Wichmann [Allemagne] ; Elisabeth Widen [Finlande] ; Colette Jm Wijnands-Van Gent [Pays-Bas] ; Gonneke Willemsen [Pays-Bas] ; James F. Wilson [Royaume-Uni] ; Bruce Hr Wolffenbuttel [Pays-Bas] ; Alan F. Wright [Royaume-Uni] ; Laura M. Yerges-Armstrong [États-Unis] ; Tatijana Zemunik [Croatie] ; Lina Zgaga [Royaume-Uni, Croatie] ; M. Carola Zillikens [Pays-Bas] ; Marek Zygmunt [Allemagne] ; Alice M. Arnold [États-Unis] ; Dorret I. Boomsma [Pays-Bas] ; Julie E. Buring [États-Unis] ; Laura Crisponi [Italie] ; Ellen W. Demerath [États-Unis] ; Vilmundur Gudnason [Islande] ; Tamara B. Harris [États-Unis] ; Frank B. Hu [États-Unis] ; David J. Hunter [États-Unis] ; Lenore J. Launer [États-Unis] ; Andres Metspalu [Estonie] ; Grant W. Montgomery [Australie] ; Ben A. Oostra [Pays-Bas] ; Paul M. Ridker [États-Unis] ; Serena Sanna [Italie] ; David Schlessinger [États-Unis] ; Tim D. Spector [Royaume-Uni] ; Kari Stefansson [Islande] ; Elizabeth A. Streeten [États-Unis] ; Unnur Thorsteinsdottir [Islande] ; Manuela Uda [Italie] ; André G. Uitterlinden [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Henry Völzke [Allemagne] ; Anna Murray [Royaume-Uni] ; Joanne M. Murabito [États-Unis] ; Jenny A. Visser [Pays-Bas] ; Kathryn L. Lunetta [États-Unis]Source :
- Nature genetics [ 1061-4036 ] ; 2012.
Abstract
To identify novel loci for age at natural menopause, we performed a meta-analysis of 22 genome-wide association studies in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 new age at natural menopause loci (
Url:
DOI: 10.1038/ng.1051
PubMed: 22267201
PubMed Central: 3288642
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Daniel I. Chasman<affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="A79">Genetic and Molecular Epidemiology Laboratory, McMaster University, Hamilton, ON Canada</nlm:aff><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation><nlm:aff id="A81">Foundation Medicine, Inc., Cambridge MA USA</nlm:aff><wicri:noCountry code="subfield">Cambridge MA USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="A103">Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald</nlm:aff><wicri:noCountry code="subfield">University of Greifswald</wicri:noCountry></affiliation><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A111">Harvard School of Public Health, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A111">Harvard School of Public Health, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A113">Division of Cardiology, Brigham and Women’s Hospital, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Cardiology, Brigham and Women’s Hospital, Boston</wicri:cityArea></affiliation>Le document en format XML
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Byrne</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation wicri:level="1"><nlm:aff id="A14">Interfakultäres Institut für Genomforschung, Universität Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfakultäres Institut für Genomforschung, Universität Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Estonian Biocenter, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Franceschini, Nora" sort="Franceschini, Nora" uniqKey="Franceschini N" first="Nora" last="Franceschini">Nora Franceschini</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F" last="Gudbjartsson">Daniel F. Gudbjartsson</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Broad Institute of Harvard and MIT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute of Harvard and MIT</wicri:regionArea></affiliation></author><author><name sortKey="Mcardle, Patick F" sort="Mcardle, Patick F" uniqKey="Mcardle P" first="Patick F" last="Mcardle">Patick F. Mcardle</name><affiliation wicri:level="1"><nlm:aff id="A22">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Van Wingerden, Sophie" sort="Van Wingerden, Sophie" uniqKey="Van Wingerden S" first="Sophie" last="Van Wingerden">Sophie Van Wingerden</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A27">Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL</wicri:regionArea></affiliation></author><author><name sortKey="Zhuang, Wei V" sort="Zhuang, Wei V" uniqKey="Zhuang W" first="Wei V" last="Zhuang">Wei V. Zhuang</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation wicri:level="1"><nlm:aff id="A29">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Alizadeh, Behrooz Z" sort="Alizadeh, Behrooz Z" uniqKey="Alizadeh B" first="Behrooz Z" last="Alizadeh">Behrooz Z. Alizadeh</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation wicri:level="1"><nlm:aff id="A31">Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Unit, Azienda Sanitaria di Firenze, Florence</wicri:regionArea></affiliation></author><author><name sortKey="Lauc, Lovorka Barac" sort="Lauc, Lovorka Barac" uniqKey="Lauc L" first="Lovorka Barac" last="Lauc">Lovorka Barac Lauc</name><affiliation wicri:level="1"><nlm:aff id="A32">Croation Science Foundation, Zagreb, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croation Science Foundation, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S" last="Beckmann">Jacques S. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="A33">Department of Medical Genetics, University of Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A34">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="1"><nlm:aff id="A11">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Broekmans, Frank J" sort="Broekmans, Frank J" uniqKey="Broekmans F" first="Frank J" last="Broekmans">Frank J. Broekmans</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Burri, Andrea" sort="Burri, Andrea" uniqKey="Burri A" first="Andrea" last="Burri">Andrea Burri</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="A37">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A38">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C" last="Cornelis">Marilyn C. Cornelis</name><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Corre, Tanguy" sort="Corre, Tanguy" uniqKey="Corre T" first="Tanguy" last="Corre">Tanguy Corre</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Coviello, Andrea D" sort="Coviello, Andrea D" uniqKey="Coviello A" first="Andrea D" last="Coviello">Andrea D. Coviello</name><affiliation wicri:level="1"><nlm:aff id="A41">Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="D Damo, Pio" sort="D Damo, Pio" uniqKey="D Damo P" first="Pio" last="D Damo">Pio D Damo</name><affiliation wicri:level="1"><nlm:aff id="A43">Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">University of Trieste, Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Trieste, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation wicri:level="1"><nlm:aff id="A46">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A47">EMGO+ Institute, VU Medical Centre, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>EMGO+ Institute, VU Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Dedoussis, George Vz" sort="Dedoussis, George Vz" uniqKey="Dedoussis G" first="George Vz" last="Dedoussis">George Vz Dedoussis</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Nutrition and Dietetics, Harokopio University, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Nutrition and Dietetics, Harokopio University, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Deloukas, Panagiotis" sort="Deloukas, Panagiotis" uniqKey="Deloukas P" first="Panagiotis" last="Deloukas">Panagiotis Deloukas</name><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Epidemiology & Population Healths, London School of Hygiene & Tropical Medicine, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Population Healths, London School of Hygiene & Tropical Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:aff id="A51">National Institute for Health and Welfare, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Department of General Practice and Primary Health Care, University of Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, Unit of General Practice, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Folkhalsan Research Centre, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhalsan Research Centre, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Vasa Central Hospital, Vasa, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Vasa Central Hospital, Vasa</wicri:regionArea></affiliation></author><author><name sortKey="Fauser, Bart Cjm" sort="Fauser, Bart Cjm" uniqKey="Fauser B" first="Bart Cjm" last="Fauser">Bart Cjm Fauser</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Ferreli, Liana" sort="Ferreli, Liana" uniqKey="Ferreli L" first="Liana" last="Ferreli">Liana Ferreli</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="A56">Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R" last="Folsom">Aaron R. Folsom</name><affiliation wicri:level="1"><nlm:aff id="A57">Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Garcia, Melissa E" sort="Garcia, Melissa E" uniqKey="Garcia M" first="Melissa E" last="Garcia">Melissa E. Garcia</name><affiliation wicri:level="1"><nlm:aff id="A58">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation wicri:level="1"><nlm:aff id="A43">Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">University of Trieste, Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Trieste, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="A29">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name><affiliation wicri:level="1"><nlm:aff id="A41">Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA</wicri:regionArea></affiliation></author><author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E" last="Grobbee">Diederick E. Grobbee</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Haller, Toomas" sort="Haller, Toomas" uniqKey="Haller T" first="Toomas" last="Haller">Toomas Haller</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E" last="Hankinson">Susan E. Hankinson</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hass, Merli" sort="Hass, Merli" uniqKey="Hass M" first="Merli" last="Hass">Merli Hass</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="A62">MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C" last="Heath">Andrew C. Heath</name><affiliation wicri:level="1"><nlm:aff id="A63">Washington University St.Louis, St. Louis, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University St.Louis, St. Louis, MO</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium of Healthy Aging, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Janssens, A Cecile Jw" sort="Janssens, A Cecile Jw" uniqKey="Janssens A" first="A Cecile Jw" last="Janssens">A Cecile Jw Janssens</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D" last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Karasik, David" sort="Karasik, David" uniqKey="Karasik D" first="David" last="Karasik">David Karasik</name><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A64">Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kardia, Sharon Lr" sort="Kardia, Sharon Lr" uniqKey="Kardia S" first="Sharon Lr" last="Kardia">Sharon Lr Kardia</name><affiliation wicri:level="1"><nlm:aff id="A65">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Keyzer, Jules" sort="Keyzer, Jules" uniqKey="Keyzer J" first="Jules" last="Keyzer">Jules Keyzer</name><affiliation wicri:level="1"><nlm:aff id="A66">Diagnostic GP laboratory Eindhoven, Eindhoven, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Diagnostic GP laboratory Eindhoven, Eindhoven</wicri:regionArea></affiliation></author><author><name sortKey="Kiel, Douglas P" sort="Kiel, Douglas P" uniqKey="Kiel D" first="Douglas P" last="Kiel">Douglas P. Kiel</name><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A64">Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation wicri:level="1"><nlm:aff id="A33">Department of Medical Genetics, University of Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Swiss Institute of Bioinformatics, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics</wicri:regionArea></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="1"><nlm:aff id="A68">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Lai, Sandra" sort="Lai, Sandra" uniqKey="Lai S" first="Sandra" last="Lai">Sandra Lai</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Laisk, Triin" sort="Laisk, Triin" uniqKey="Laisk T" first="Triin" last="Laisk">Triin Laisk</name><affiliation wicri:level="1"><nlm:aff id="A69">Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Laven, Joop Se" sort="Laven, Joop Se" uniqKey="Laven J" first="Joop Se" last="Laven">Joop Se Laven</name><affiliation wicri:level="1"><nlm:aff id="A70">Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation wicri:level="1"><nlm:aff id="A71">MRC Centre for Causal Analysis in Translational Epidemiology, School of Social & Community Medicine, University of Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analysis in Translational Epidemiology, School of Social & Community Medicine, University of Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="A72">Human genetic, Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Human genetic, Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Louwers, Yvonne V" sort="Louwers, Yvonne V" uniqKey="Louwers Y" first="Yvonne V" last="Louwers">Yvonne V. Louwers</name><affiliation wicri:level="1"><nlm:aff id="A70">Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Magnusson, Patrik Ke" sort="Magnusson, Patrik Ke" uniqKey="Magnusson P" first="Patrik Ke" last="Magnusson">Patrik Ke Magnusson</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Marongiu, Mara" sort="Marongiu, Mara" uniqKey="Marongiu M" first="Mara" last="Marongiu">Mara Marongiu</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Klaric, Irena Martinovic" sort="Klaric, Irena Martinovic" uniqKey="Klaric I" first="Irena Martinovic" last="Klaric">Irena Martinovic Klaric</name><affiliation wicri:level="1"><nlm:aff id="A73">Institute for Migration and Ethnic Studies, Zagreb, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Institute for Migration and Ethnic Studies, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Masciullo, Corrado" sort="Masciullo, Corrado" uniqKey="Masciullo C" first="Corrado" last="Masciullo">Corrado Masciullo</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E" last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Melzer, David" sort="Melzer, David" uniqKey="Melzer D" first="David" last="Melzer">David Melzer</name><affiliation wicri:level="1"><nlm:aff id="A3">Peninsula Medical School, University of Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula Medical School, University of Exeter</wicri:regionArea></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation wicri:level="1"><nlm:aff id="A75">Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation wicri:level="1"><nlm:aff id="A62">MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B" last="Newman">Anne B. Newman</name><affiliation wicri:level="2"><nlm:aff id="A76">Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R" last="Nyholt">Dale R. Nyholt</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A78">Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Paré">Guillaume Paré</name><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="A79">Genetic and Molecular Epidemiology Laboratory, McMaster University, Hamilton, ON Canada</nlm:aff><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Parker, Alex N" sort="Parker, Alex N" uniqKey="Parker A" first="Alex N" last="Parker">Alex N. Parker</name><affiliation wicri:level="2"><nlm:aff id="A80">Amgen, Cambridge, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Amgen, Cambridge</wicri:cityArea></affiliation><affiliation><nlm:aff id="A81">Foundation Medicine, Inc., Cambridge MA USA</nlm:aff><wicri:noCountry code="subfield">Cambridge MA USA</wicri:noCountry></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra Hm" sort="Peeters, Petra Hm" uniqKey="Peeters P" first="Petra Hm" last="Peeters">Petra Hm Peeters</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A82">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Plump, Andrew S" sort="Plump, Andrew S" uniqKey="Plump A" first="Andrew S" last="Plump">Andrew S. Plump</name><affiliation wicri:level="1"><nlm:aff id="A83">Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Pop, Victor Jm" sort="Pop, Victor Jm" uniqKey="Pop V" first="Victor Jm" last="Pop">Victor Jm Pop</name><affiliation wicri:level="1"><nlm:aff id="A84">Department of Clinical Health Psychology, University of Tilburg, Tilburg, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Health Psychology, University of Tilburg, Tilburg</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="2"><nlm:aff id="A85">Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A86">Group Health Research Institute, Group Health Cooperative, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Group Health Cooperative, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation wicri:level="1"><nlm:aff id="A68">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Rehnberg, Emil" sort="Rehnberg, Emil" uniqKey="Rehnberg E" first="Emil" last="Rehnberg">Emil Rehnberg</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="1"><nlm:aff id="A87">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Competence Centre on Reproductive Medicine and Biology, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Scuteri, Angelo" sort="Scuteri, Angelo" uniqKey="Scuteri A" first="Angelo" last="Scuteri">Angelo Scuteri</name><affiliation wicri:level="1"><nlm:aff id="A89">Lab Cardiovascular Sciences - NIA - NIH, Baltimore, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lab Cardiovascular Sciences - NIA - NIH, Baltimore</wicri:regionArea></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="1"><nlm:aff id="A90">Laboratory of Neurogenetics, National Institute of Ageing, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute of Ageing, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Jennifer A" sort="Smith, Jennifer A" uniqKey="Smith J" first="Jennifer A" last="Smith">Jennifer A. Smith</name><affiliation wicri:level="1"><nlm:aff id="A65">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N" last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:aff id="A48">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A92">Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Geriatric Medicine Unit, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Stathopoulou, Maria G" sort="Stathopoulou, Maria G" uniqKey="Stathopoulou M" first="Maria G" last="Stathopoulou">Maria G. Stathopoulou</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Nutrition and Dietetics, Harokopio University, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Nutrition and Dietetics, Harokopio University, Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A93">Cardiovascular Genetics Research Unit, EA4373, Université Henri Poincaré - Nancy 1, Nancy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Cardiovascular Genetics Research Unit, EA4373, Université Henri Poincaré - Nancy 1, Nancy</wicri:regionArea></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Styrkarsdottir, Unnur" sort="Styrkarsdottir, Unnur" uniqKey="Styrkarsdottir U" first="Unnur" last="Styrkarsdottir">Unnur Styrkarsdottir</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Yan V" sort="Sun, Yan V" uniqKey="Sun Y" first="Yan V" last="Sun">Yan V. Sun</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Epidemiology, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><affiliation wicri:level="1"><nlm:aff id="A62">MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A95">The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin</wicri:regionArea></affiliation></author><author><name sortKey="Thorand, Barbara" sort="Thorand, Barbara" uniqKey="Thorand B" first="Barbara" last="Thorand">Barbara Thorand</name><affiliation wicri:level="1"><nlm:aff id="A96">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A97">Institute of Molecular Genetics-CNR, Pavia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Molecular Genetics-CNR, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Tryggvadottir, Laufey" sort="Tryggvadottir, Laufey" uniqKey="Tryggvadottir L" first="Laufey" last="Tryggvadottir">Laufey Tryggvadottir</name><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A98">Icelandic Cancer Registry, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Cancer Registry, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Tsui, Kim" sort="Tsui, Kim" uniqKey="Tsui K" first="Kim" last="Tsui">Kim Tsui</name><affiliation wicri:level="2"><nlm:aff id="A80">Amgen, Cambridge, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Amgen, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation wicri:level="1"><nlm:aff id="A43">Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Van Dam, Rob M" sort="Van Dam, Rob M" uniqKey="Van Dam R" first="Rob M" last="Van Dam">Rob M. Van Dam</name><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A99">Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Van Gils, Carla H" sort="Van Gils, Carla H" uniqKey="Van Gils C" first="Carla H" last="Van Gils">Carla H. Van Gils</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Van Nierop, Peter" sort="Van Nierop, Peter" uniqKey="Van Nierop P" first="Peter" last="Van Nierop">Peter Van Nierop</name><affiliation wicri:level="1"><nlm:aff id="A100">Municipal Health Service Brabant-Zuidoost, Helmond, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Municipal Health Service Brabant-Zuidoost, Helmond</wicri:regionArea></affiliation></author><author><name sortKey="Vink, Jacqueline M" sort="Vink, Jacqueline M" uniqKey="Vink J" first="Jacqueline M" last="Vink">Jacqueline M. Vink</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M" last="Visscher">Peter M. Visscher</name><affiliation wicri:level="1"><nlm:aff id="A48">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A101">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Voorhuis, Marlies" sort="Voorhuis, Marlies" uniqKey="Voorhuis M" first="Marlies" last="Voorhuis">Marlies Voorhuis</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation wicri:level="1"><nlm:aff id="A102">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A103">Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald</nlm:aff><wicri:noCountry code="subfield">University of Greifswald</wicri:noCountry></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H Erich" last="Wichmann">H Erich Wichmann</name><affiliation wicri:level="1"><nlm:aff id="A104">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A105">Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A106">Klinikum Grosshadern, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Grosshadern, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation wicri:level="1"><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Gent, Colette Jm Wijnands Van" sort="Gent, Colette Jm Wijnands Van" uniqKey="Gent C" first="Colette Jm Wijnands-Van" last="Gent">Colette Jm Wijnands-Van Gent</name><affiliation wicri:level="1"><nlm:aff id="A107">POZOB Veldhoven, Veldhoven, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>POZOB Veldhoven, Veldhoven</wicri:regionArea></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="A37">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce Hr" sort="Wolffenbuttel, Bruce Hr" uniqKey="Wolffenbuttel B" first="Bruce Hr" last="Wolffenbuttel">Bruce Hr Wolffenbuttel</name><affiliation wicri:level="1"><nlm:aff id="A91">LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A108">Department of Endocrinology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation wicri:level="1"><nlm:aff id="A62">MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Yerges Armstrong, Laura M" sort="Yerges Armstrong, Laura M" uniqKey="Yerges Armstrong L" first="Laura M" last="Yerges-Armstrong">Laura M. Yerges-Armstrong</name><affiliation wicri:level="1"><nlm:aff id="A22">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation wicri:level="1"><nlm:aff id="A37">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A109">Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M. Carola" last="Zillikens">M. Carola Zillikens</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Zygmunt, Marek" sort="Zygmunt, Marek" uniqKey="Zygmunt M" first="Marek" last="Zygmunt">Marek Zygmunt</name><affiliation wicri:level="1"><nlm:aff id="A110">Klinik für Gynäkologie und Geburtshilfe, Universität Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Gynäkologie und Geburtshilfe, Universität Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M" last="Arnold">Alice M. Arnold</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A47">EMGO+ Institute, VU Medical Centre, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>EMGO+ Institute, VU Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A111">Harvard School of Public Health, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Crisponi, Laura" sort="Crisponi, Laura" uniqKey="Crisponi L" first="Laura" last="Crisponi">Laura Crisponi</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Demerath, Ellen W" sort="Demerath, Ellen W" uniqKey="Demerath E" first="Ellen W" last="Demerath">Ellen W. Demerath</name><affiliation wicri:level="1"><nlm:aff id="A57">Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="A58">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Broad Institute of Harvard and MIT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute of Harvard and MIT</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="A58">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Estonian Biocenter, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Competence Centre on Reproductive Medicine and Biology, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="A112">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A111">Harvard School of Public Health, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A113">Division of Cardiology, Brigham and Women’s Hospital, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Cardiology, Brigham and Women’s Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation wicri:level="1"><nlm:aff id="A114">National Institute on Aging, Intramural Research Program, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Intramural Research Program, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Streeten, Elizabeth A" sort="Streeten, Elizabeth A" uniqKey="Streeten E" first="Elizabeth A" last="Streeten">Elizabeth A. Streeten</name><affiliation wicri:level="1"><nlm:aff id="A22">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium of Healthy Aging, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium of Healthy Aging, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="A115">Institut für Community Medicine, Universität Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Community Medicine, Universität Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Murray, Anna" sort="Murray, Anna" uniqKey="Murray A" first="Anna" last="Murray">Anna Murray</name><affiliation wicri:level="1"><nlm:aff id="A3">Peninsula Medical School, University of Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula Medical School, University of Exeter</wicri:regionArea></affiliation></author><author><name sortKey="Murabito, Joanne M" sort="Murabito, Joanne M" uniqKey="Murabito J" first="Joanne M" last="Murabito">Joanne M. Murabito</name><affiliation wicri:level="1"><nlm:aff id="A41">Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Visser, Jenny A" sort="Visser, Jenny A" uniqKey="Visser J" first="Jenny A" last="Visser">Jenny A. Visser</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22267201</idno><idno type="pmc">3288642</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288642</idno><idno type="RBID">PMC:3288642</idno><idno type="doi">10.1038/ng.1051</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002E11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E11</idno><idno type="wicri:Area/Pmc/Curation">002C61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analyses identify 13 novel loci associated with age at menopause and highlights DNA repair and immune pathways</title><author><name sortKey="Stolk, Lisette" sort="Stolk, Lisette" uniqKey="Stolk L" first="Lisette" last="Stolk">Lisette Stolk</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium of Healthy Aging, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Perry, John Rb" sort="Perry, John Rb" uniqKey="Perry J" first="John Rb" last="Perry">John Rb Perry</name><affiliation wicri:level="1"><nlm:aff id="A3">Peninsula Medical School, University of Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula Medical School, University of Exeter</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation></author><author><name sortKey="He, Chunyan" sort="He, Chunyan" uniqKey="He C" first="Chunyan" last="He">Chunyan He</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Public Health, Indiana University School of Medicine, Indianapolis, Indiana, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Public Health, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana</wicri:regionArea></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Barbalic, Maja" sort="Barbalic, Maja" uniqKey="Barbalic M" first="Maja" last="Barbalic">Maja Barbalic</name><affiliation wicri:level="1"><nlm:aff id="A11">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Broer, Linda" sort="Broer, Linda" uniqKey="Broer L" first="Linda" last="Broer">Linda Broer</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Byrne, Enda M" sort="Byrne, Enda M" uniqKey="Byrne E" first="Enda M" last="Byrne">Enda M. Byrne</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation wicri:level="1"><nlm:aff id="A14">Interfakultäres Institut für Genomforschung, Universität Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfakultäres Institut für Genomforschung, Universität Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Estonian Biocenter, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Franceschini, Nora" sort="Franceschini, Nora" uniqKey="Franceschini N" first="Nora" last="Franceschini">Nora Franceschini</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F" last="Gudbjartsson">Daniel F. Gudbjartsson</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Broad Institute of Harvard and MIT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute of Harvard and MIT</wicri:regionArea></affiliation></author><author><name sortKey="Mcardle, Patick F" sort="Mcardle, Patick F" uniqKey="Mcardle P" first="Patick F" last="Mcardle">Patick F. Mcardle</name><affiliation wicri:level="1"><nlm:aff id="A22">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Van Wingerden, Sophie" sort="Van Wingerden, Sophie" uniqKey="Van Wingerden S" first="Sophie" last="Van Wingerden">Sophie Van Wingerden</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A27">Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL</wicri:regionArea></affiliation></author><author><name sortKey="Zhuang, Wei V" sort="Zhuang, Wei V" uniqKey="Zhuang W" first="Wei V" last="Zhuang">Wei V. Zhuang</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation wicri:level="1"><nlm:aff id="A29">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Alizadeh, Behrooz Z" sort="Alizadeh, Behrooz Z" uniqKey="Alizadeh B" first="Behrooz Z" last="Alizadeh">Behrooz Z. Alizadeh</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation wicri:level="1"><nlm:aff id="A31">Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Unit, Azienda Sanitaria di Firenze, Florence</wicri:regionArea></affiliation></author><author><name sortKey="Lauc, Lovorka Barac" sort="Lauc, Lovorka Barac" uniqKey="Lauc L" first="Lovorka Barac" last="Lauc">Lovorka Barac Lauc</name><affiliation wicri:level="1"><nlm:aff id="A32">Croation Science Foundation, Zagreb, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croation Science Foundation, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S" last="Beckmann">Jacques S. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="A33">Department of Medical Genetics, University of Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A34">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="1"><nlm:aff id="A11">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Broekmans, Frank J" sort="Broekmans, Frank J" uniqKey="Broekmans F" first="Frank J" last="Broekmans">Frank J. Broekmans</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Burri, Andrea" sort="Burri, Andrea" uniqKey="Burri A" first="Andrea" last="Burri">Andrea Burri</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="A37">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A38">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C" last="Cornelis">Marilyn C. Cornelis</name><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Corre, Tanguy" sort="Corre, Tanguy" uniqKey="Corre T" first="Tanguy" last="Corre">Tanguy Corre</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Coviello, Andrea D" sort="Coviello, Andrea D" uniqKey="Coviello A" first="Andrea D" last="Coviello">Andrea D. Coviello</name><affiliation wicri:level="1"><nlm:aff id="A41">Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="D Damo, Pio" sort="D Damo, Pio" uniqKey="D Damo P" first="Pio" last="D Damo">Pio D Damo</name><affiliation wicri:level="1"><nlm:aff id="A43">Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">University of Trieste, Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Trieste, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation wicri:level="1"><nlm:aff id="A46">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A47">EMGO+ Institute, VU Medical Centre, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>EMGO+ Institute, VU Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Dedoussis, George Vz" sort="Dedoussis, George Vz" uniqKey="Dedoussis G" first="George Vz" last="Dedoussis">George Vz Dedoussis</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Nutrition and Dietetics, Harokopio University, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Nutrition and Dietetics, Harokopio University, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Deloukas, Panagiotis" sort="Deloukas, Panagiotis" uniqKey="Deloukas P" first="Panagiotis" last="Deloukas">Panagiotis Deloukas</name><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Epidemiology & Population Healths, London School of Hygiene & Tropical Medicine, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Population Healths, London School of Hygiene & Tropical Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:aff id="A51">National Institute for Health and Welfare, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Department of General Practice and Primary Health Care, University of Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, Unit of General Practice, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Folkhalsan Research Centre, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Folkhalsan Research Centre, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Vasa Central Hospital, Vasa, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Vasa Central Hospital, Vasa</wicri:regionArea></affiliation></author><author><name sortKey="Fauser, Bart Cjm" sort="Fauser, Bart Cjm" uniqKey="Fauser B" first="Bart Cjm" last="Fauser">Bart Cjm Fauser</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Ferreli, Liana" sort="Ferreli, Liana" uniqKey="Ferreli L" first="Liana" last="Ferreli">Liana Ferreli</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="A56">Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R" last="Folsom">Aaron R. Folsom</name><affiliation wicri:level="1"><nlm:aff id="A57">Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Garcia, Melissa E" sort="Garcia, Melissa E" uniqKey="Garcia M" first="Melissa E" last="Garcia">Melissa E. Garcia</name><affiliation wicri:level="1"><nlm:aff id="A58">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation wicri:level="1"><nlm:aff id="A43">Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">University of Trieste, Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Trieste, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="A29">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name><affiliation wicri:level="1"><nlm:aff id="A41">Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA</wicri:regionArea></affiliation></author><author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E" last="Grobbee">Diederick E. Grobbee</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Haller, Toomas" sort="Haller, Toomas" uniqKey="Haller T" first="Toomas" last="Haller">Toomas Haller</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E" last="Hankinson">Susan E. Hankinson</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hass, Merli" sort="Hass, Merli" uniqKey="Hass M" first="Merli" last="Hass">Merli Hass</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="A62">MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C" last="Heath">Andrew C. Heath</name><affiliation wicri:level="1"><nlm:aff id="A63">Washington University St.Louis, St. Louis, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University St.Louis, St. Louis, MO</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium of Healthy Aging, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Janssens, A Cecile Jw" sort="Janssens, A Cecile Jw" uniqKey="Janssens A" first="A Cecile Jw" last="Janssens">A Cecile Jw Janssens</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D" last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Karasik, David" sort="Karasik, David" uniqKey="Karasik D" first="David" last="Karasik">David Karasik</name><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A64">Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kardia, Sharon Lr" sort="Kardia, Sharon Lr" uniqKey="Kardia S" first="Sharon Lr" last="Kardia">Sharon Lr Kardia</name><affiliation wicri:level="1"><nlm:aff id="A65">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Keyzer, Jules" sort="Keyzer, Jules" uniqKey="Keyzer J" first="Jules" last="Keyzer">Jules Keyzer</name><affiliation wicri:level="1"><nlm:aff id="A66">Diagnostic GP laboratory Eindhoven, Eindhoven, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Diagnostic GP laboratory Eindhoven, Eindhoven</wicri:regionArea></affiliation></author><author><name sortKey="Kiel, Douglas P" sort="Kiel, Douglas P" uniqKey="Kiel D" first="Douglas P" last="Kiel">Douglas P. Kiel</name><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A64">Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation wicri:level="1"><nlm:aff id="A33">Department of Medical Genetics, University of Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Swiss Institute of Bioinformatics, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics</wicri:regionArea></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="1"><nlm:aff id="A68">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Lai, Sandra" sort="Lai, Sandra" uniqKey="Lai S" first="Sandra" last="Lai">Sandra Lai</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Laisk, Triin" sort="Laisk, Triin" uniqKey="Laisk T" first="Triin" last="Laisk">Triin Laisk</name><affiliation wicri:level="1"><nlm:aff id="A69">Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Laven, Joop Se" sort="Laven, Joop Se" uniqKey="Laven J" first="Joop Se" last="Laven">Joop Se Laven</name><affiliation wicri:level="1"><nlm:aff id="A70">Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation wicri:level="1"><nlm:aff id="A71">MRC Centre for Causal Analysis in Translational Epidemiology, School of Social & Community Medicine, University of Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analysis in Translational Epidemiology, School of Social & Community Medicine, University of Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="A72">Human genetic, Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Human genetic, Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="1"><nlm:aff id="A45">Department of Psychology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Louwers, Yvonne V" sort="Louwers, Yvonne V" uniqKey="Louwers Y" first="Yvonne V" last="Louwers">Yvonne V. Louwers</name><affiliation wicri:level="1"><nlm:aff id="A70">Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Magnusson, Patrik Ke" sort="Magnusson, Patrik Ke" uniqKey="Magnusson P" first="Patrik Ke" last="Magnusson">Patrik Ke Magnusson</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Marongiu, Mara" sort="Marongiu, Mara" uniqKey="Marongiu M" first="Mara" last="Marongiu">Mara Marongiu</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Klaric, Irena Martinovic" sort="Klaric, Irena Martinovic" uniqKey="Klaric I" first="Irena Martinovic" last="Klaric">Irena Martinovic Klaric</name><affiliation wicri:level="1"><nlm:aff id="A73">Institute for Migration and Ethnic Studies, Zagreb, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Institute for Migration and Ethnic Studies, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Masciullo, Corrado" sort="Masciullo, Corrado" uniqKey="Masciullo C" first="Corrado" last="Masciullo">Corrado Masciullo</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E" last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Melzer, David" sort="Melzer, David" uniqKey="Melzer D" first="David" last="Melzer">David Melzer</name><affiliation wicri:level="1"><nlm:aff id="A3">Peninsula Medical School, University of Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula Medical School, University of Exeter</wicri:regionArea></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation wicri:level="1"><nlm:aff id="A75">Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation wicri:level="1"><nlm:aff id="A62">MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B" last="Newman">Anne B. Newman</name><affiliation wicri:level="2"><nlm:aff id="A76">Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R" last="Nyholt">Dale R. Nyholt</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A78">Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Paré">Guillaume Paré</name><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="A79">Genetic and Molecular Epidemiology Laboratory, McMaster University, Hamilton, ON Canada</nlm:aff><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Parker, Alex N" sort="Parker, Alex N" uniqKey="Parker A" first="Alex N" last="Parker">Alex N. Parker</name><affiliation wicri:level="2"><nlm:aff id="A80">Amgen, Cambridge, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Amgen, Cambridge</wicri:cityArea></affiliation><affiliation><nlm:aff id="A81">Foundation Medicine, Inc., Cambridge MA USA</nlm:aff><wicri:noCountry code="subfield">Cambridge MA USA</wicri:noCountry></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Peeters, Petra Hm" sort="Peeters, Petra Hm" uniqKey="Peeters P" first="Petra Hm" last="Peeters">Petra Hm Peeters</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A82">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Plump, Andrew S" sort="Plump, Andrew S" uniqKey="Plump A" first="Andrew S" last="Plump">Andrew S. Plump</name><affiliation wicri:level="1"><nlm:aff id="A83">Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Pop, Victor Jm" sort="Pop, Victor Jm" uniqKey="Pop V" first="Victor Jm" last="Pop">Victor Jm Pop</name><affiliation wicri:level="1"><nlm:aff id="A84">Department of Clinical Health Psychology, University of Tilburg, Tilburg, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Health Psychology, University of Tilburg, Tilburg</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="2"><nlm:aff id="A85">Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A86">Group Health Research Institute, Group Health Cooperative, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Group Health Cooperative, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation wicri:level="1"><nlm:aff id="A68">Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Rehnberg, Emil" sort="Rehnberg, Emil" uniqKey="Rehnberg E" first="Emil" last="Rehnberg">Emil Rehnberg</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="1"><nlm:aff id="A87">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Competence Centre on Reproductive Medicine and Biology, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Scuteri, Angelo" sort="Scuteri, Angelo" uniqKey="Scuteri A" first="Angelo" last="Scuteri">Angelo Scuteri</name><affiliation wicri:level="1"><nlm:aff id="A89">Lab Cardiovascular Sciences - NIA - NIH, Baltimore, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lab Cardiovascular Sciences - NIA - NIH, Baltimore</wicri:regionArea></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="1"><nlm:aff id="A90">Laboratory of Neurogenetics, National Institute of Ageing, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute of Ageing, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Jennifer A" sort="Smith, Jennifer A" uniqKey="Smith J" first="Jennifer A" last="Smith">Jennifer A. Smith</name><affiliation wicri:level="1"><nlm:aff id="A65">Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N" last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:aff id="A48">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A92">Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Geriatric Medicine Unit, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Stathopoulou, Maria G" sort="Stathopoulou, Maria G" uniqKey="Stathopoulou M" first="Maria G" last="Stathopoulou">Maria G. Stathopoulou</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Nutrition and Dietetics, Harokopio University, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Nutrition and Dietetics, Harokopio University, Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A93">Cardiovascular Genetics Research Unit, EA4373, Université Henri Poincaré - Nancy 1, Nancy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Cardiovascular Genetics Research Unit, EA4373, Université Henri Poincaré - Nancy 1, Nancy</wicri:regionArea></affiliation></author><author><name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name><affiliation wicri:level="1"><nlm:aff id="A24">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Styrkarsdottir, Unnur" sort="Styrkarsdottir, Unnur" uniqKey="Styrkarsdottir U" first="Unnur" last="Styrkarsdottir">Unnur Styrkarsdottir</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Yan V" sort="Sun, Yan V" uniqKey="Sun Y" first="Yan V" last="Sun">Yan V. Sun</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Epidemiology, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><affiliation wicri:level="1"><nlm:aff id="A62">MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A95">The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin</wicri:regionArea></affiliation></author><author><name sortKey="Thorand, Barbara" sort="Thorand, Barbara" uniqKey="Thorand B" first="Barbara" last="Thorand">Barbara Thorand</name><affiliation wicri:level="1"><nlm:aff id="A96">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A97">Institute of Molecular Genetics-CNR, Pavia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Molecular Genetics-CNR, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Tryggvadottir, Laufey" sort="Tryggvadottir, Laufey" uniqKey="Tryggvadottir L" first="Laufey" last="Tryggvadottir">Laufey Tryggvadottir</name><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A98">Icelandic Cancer Registry, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Cancer Registry, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Tsui, Kim" sort="Tsui, Kim" uniqKey="Tsui K" first="Kim" last="Tsui">Kim Tsui</name><affiliation wicri:level="2"><nlm:aff id="A80">Amgen, Cambridge, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Amgen, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation wicri:level="1"><nlm:aff id="A43">Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Van Dam, Rob M" sort="Van Dam, Rob M" uniqKey="Van Dam R" first="Rob M" last="Van Dam">Rob M. Van Dam</name><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A99">Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Van Gils, Carla H" sort="Van Gils, Carla H" uniqKey="Van Gils C" first="Carla H" last="Van Gils">Carla H. Van Gils</name><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Van Nierop, Peter" sort="Van Nierop, Peter" uniqKey="Van Nierop P" first="Peter" last="Van Nierop">Peter Van Nierop</name><affiliation wicri:level="1"><nlm:aff id="A100">Municipal Health Service Brabant-Zuidoost, Helmond, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Municipal Health Service Brabant-Zuidoost, Helmond</wicri:regionArea></affiliation></author><author><name sortKey="Vink, Jacqueline M" sort="Vink, Jacqueline M" uniqKey="Vink J" first="Jacqueline M" last="Vink">Jacqueline M. Vink</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M" last="Visscher">Peter M. Visscher</name><affiliation wicri:level="1"><nlm:aff id="A48">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A101">Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Voorhuis, Marlies" sort="Voorhuis, Marlies" uniqKey="Voorhuis M" first="Marlies" last="Voorhuis">Marlies Voorhuis</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A59">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation wicri:level="1"><nlm:aff id="A102">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A103">Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald</nlm:aff><wicri:noCountry code="subfield">University of Greifswald</wicri:noCountry></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H Erich" last="Wichmann">H Erich Wichmann</name><affiliation wicri:level="1"><nlm:aff id="A104">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A105">Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A106">Klinikum Grosshadern, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Grosshadern, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation wicri:level="1"><nlm:aff id="A77">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Gent, Colette Jm Wijnands Van" sort="Gent, Colette Jm Wijnands Van" uniqKey="Gent C" first="Colette Jm Wijnands-Van" last="Gent">Colette Jm Wijnands-Van Gent</name><affiliation wicri:level="1"><nlm:aff id="A107">POZOB Veldhoven, Veldhoven, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>POZOB Veldhoven, Veldhoven</wicri:regionArea></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="A37">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce Hr" sort="Wolffenbuttel, Bruce Hr" uniqKey="Wolffenbuttel B" first="Bruce Hr" last="Wolffenbuttel">Bruce Hr Wolffenbuttel</name><affiliation wicri:level="1"><nlm:aff id="A91">LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A108">Department of Endocrinology, University Medical Center Groningen, University of Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, University Medical Center Groningen, University of Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation wicri:level="1"><nlm:aff id="A62">MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Yerges Armstrong, Laura M" sort="Yerges Armstrong, Laura M" uniqKey="Yerges Armstrong L" first="Laura M" last="Yerges-Armstrong">Laura M. Yerges-Armstrong</name><affiliation wicri:level="1"><nlm:aff id="A22">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation wicri:level="1"><nlm:aff id="A35">Faculty of Medicine, University of Split, Split, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation wicri:level="1"><nlm:aff id="A37">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A109">Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia</nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Zillikens, M Carola" sort="Zillikens, M Carola" uniqKey="Zillikens M" first="M. Carola" last="Zillikens">M. Carola Zillikens</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Zygmunt, Marek" sort="Zygmunt, Marek" uniqKey="Zygmunt M" first="Marek" last="Zygmunt">Marek Zygmunt</name><affiliation wicri:level="1"><nlm:aff id="A110">Klinik für Gynäkologie und Geburtshilfe, Universität Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Gynäkologie und Geburtshilfe, Universität Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M" last="Arnold">Alice M. Arnold</name><affiliation wicri:level="1"><nlm:aff id="A74">Department of Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:aff id="A19">Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dept Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A47">EMGO+ Institute, VU Medical Centre, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>EMGO+ Institute, VU Medical Centre, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A111">Harvard School of Public Health, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Crisponi, Laura" sort="Crisponi, Laura" uniqKey="Crisponi L" first="Laura" last="Crisponi">Laura Crisponi</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Demerath, Ellen W" sort="Demerath, Ellen W" uniqKey="Demerath E" first="Ellen W" last="Demerath">Ellen W. Demerath</name><affiliation wicri:level="1"><nlm:aff id="A57">Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A25">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="A58">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Broad Institute of Harvard and MIT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute of Harvard and MIT</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="A58">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="A15">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Estonian Biocenter, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Competence Centre on Reproductive Medicine and Biology, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="A112">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="A5">Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</nlm:aff><wicri:noCountry code="subfield">Boston USA</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Harvard Medical School, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A111">Harvard School of Public Health, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A113">Division of Cardiology, Brigham and Women’s Hospital, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Cardiology, Brigham and Women’s Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation wicri:level="1"><nlm:aff id="A114">National Institute on Aging, Intramural Research Program, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute on Aging, Intramural Research Program, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Streeten, Elizabeth A" sort="Streeten, Elizabeth A" uniqKey="Streeten E" first="Elizabeth A" last="Streeten">Elizabeth A. Streeten</name><affiliation wicri:level="1"><nlm:aff id="A22">Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="A10">deCODE Genetics, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics, Reykjavik</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation wicri:level="1"><nlm:aff id="A23">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium of Healthy Aging, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium of Healthy Aging, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="A115">Institut für Community Medicine, Universität Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Community Medicine, Universität Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Murray, Anna" sort="Murray, Anna" uniqKey="Murray A" first="Anna" last="Murray">Anna Murray</name><affiliation wicri:level="1"><nlm:aff id="A3">Peninsula Medical School, University of Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula Medical School, University of Exeter</wicri:regionArea></affiliation></author><author><name sortKey="Murabito, Joanne M" sort="Murabito, Joanne M" uniqKey="Murabito J" first="Joanne M" last="Murabito">Joanne M. Murabito</name><affiliation wicri:level="1"><nlm:aff id="A41">Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Visser, Jenny A" sort="Visser, Jenny A" uniqKey="Visser J" first="Jenny A" last="Visser">Jenny A. Visser</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">NHLBI Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">To identify novel loci for age at natural menopause, we performed a meta-analysis of 22 genome-wide association studies in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 new age at natural menopause loci (<italic>P</italic> < 5 × 10<sup>−8</sup>). The new loci included genes implicated in DNA repair (<italic>EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG, PRIM1</italic>) and immune function (<italic>IL11, NLRP11, BAT2</italic>). Gene-set enrichment pathway analyses using the full GWAS dataset identified exodeoxyribonuclease, NFκB signalling and mitochondrial dysfunction as biological processes related to timing of menopause.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Burger, Hg" uniqKey="Burger H">HG Burger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broekmans, Fj" uniqKey="Broekmans F">FJ Broekmans</name></author><author><name sortKey="Soules, Mr" uniqKey="Soules M">MR Soules</name></author><author><name sortKey="Fauser, Bc" uniqKey="Fauser B">BC Fauser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Te Velde, Er" uniqKey="Te Velde E">ER te Velde</name></author><author><name sortKey="Pearson, Pl" uniqKey="Pearson P">PL Pearson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Te Velde, Er" uniqKey="Te Velde E">ER te 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Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22267201</article-id><article-id pub-id-type="pmc">3288642</article-id><article-id pub-id-type="doi">10.1038/ng.1051</article-id><article-id pub-id-type="manuscript">NIHMS342040</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Meta-analyses identify 13 novel loci associated with age at menopause and highlights DNA repair and immune pathways</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Stolk</surname><given-names>Lisette</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib 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ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A39">39</xref><xref ref-type="aff" rid="A61">61</xref><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Launer</surname><given-names>Lenore J</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Metspalu</surname><given-names>Andres</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A88">88</xref></contrib><contrib contrib-type="author"><name><surname>Montgomery</surname><given-names>Grant W</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Oostra</surname><given-names>Ben A</given-names></name><xref ref-type="aff" rid="A112">112</xref></contrib><contrib contrib-type="author"><name><surname>Ridker</surname><given-names>Paul 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rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Thorsteinsdottir</surname><given-names>Unnur</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Uda</surname><given-names>Manuela</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Uitterlinden</surname><given-names>André G</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Völzke</surname><given-names>Henry</given-names></name><xref ref-type="aff" rid="A115">115</xref></contrib><contrib contrib-type="author"><name><surname>Murray</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref rid="FN3" ref-type="author-notes">#</xref></contrib><contrib contrib-type="author"><name><surname>Murabito</surname><given-names>Joanne M</given-names></name><xref ref-type="aff" rid="A41">41</xref><xref ref-type="aff" rid="A42">42</xref><xref rid="FN3" ref-type="author-notes">#</xref></contrib><contrib contrib-type="author"><name><surname>Visser</surname><given-names>Jenny A</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN3" ref-type="author-notes">#</xref></contrib><contrib contrib-type="author"><name><surname>Lunetta</surname><given-names>Kathryn L</given-names></name><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A42">42</xref><xref rid="FN3" ref-type="author-notes">#</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands</aff><aff id="A2"><label>2</label>Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands</aff><aff id="A3"><label>3</label>Peninsula Medical School, University of Exeter, UK</aff><aff id="A4"><label>4</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A5"><label>5</label>Division of Preventive Medicine, Brigham and Women’s Hospital, Boston USA</aff><aff id="A6"><label>6</label>Harvard Medical School, Boston, USA</aff><aff id="A7"><label>7</label>Department of Public Health, Indiana University School of Medicine, Indianapolis, Indiana, USA</aff><aff id="A8"><label>8</label>Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA</aff><aff id="A9"><label>9</label>Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</aff><aff id="A10"><label>10</label>deCODE Genetics, Reykjavik, Iceland</aff><aff id="A11"><label>11</label>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA</aff><aff id="A12"><label>12</label>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A13"><label>13</label>Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A14"><label>14</label>Interfakultäres Institut für Genomforschung, Universität Greifswald, Germany</aff><aff id="A15"><label>15</label>Estonian Genome Center, University of Tartu, Tartu, Estonia</aff><aff id="A16"><label>16</label>Estonian Biocenter, Tartu, Estonia</aff><aff id="A17"><label>17</label>Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</aff><aff id="A18"><label>18</label>Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</aff><aff id="A19"><label>19</label>Dept Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands</aff><aff id="A20"><label>20</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A21"><label>21</label>Broad Institute of Harvard and MIT, USA</aff><aff id="A22"><label>22</label>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA</aff><aff id="A23"><label>23</label>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</aff><aff id="A24"><label>24</label>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK</aff><aff id="A25"><label>25</label>Icelandic Heart Association, Kopavogur, Iceland</aff><aff id="A26"><label>26</label>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A27"><label>27</label>Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada</aff><aff id="A28"><label>28</label>Department of Biostatistics, Boston University School of Public Health, Boston Massachusetts, USA</aff><aff id="A29"><label>29</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A30"><label>30</label>Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands</aff><aff id="A31"><label>31</label>Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy</aff><aff id="A32"><label>32</label>Croation Science Foundation, Zagreb, Croatia</aff><aff id="A33"><label>33</label>Department of Medical Genetics, University of Lausanne, Switzerland</aff><aff id="A34"><label>34</label>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland</aff><aff id="A35"><label>35</label>Faculty of Medicine, University of Split, Split, Croatia</aff><aff id="A36"><label>36</label>Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands</aff><aff id="A37"><label>37</label>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</aff><aff id="A38"><label>38</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A39"><label>39</label>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A40"><label>40</label>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy</aff><aff id="A41"><label>41</label>Sections of General Internal Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston MA, USA</aff><aff id="A42"><label>42</label>NHLBI Framingham Heart Study, Framingham, MA, USA</aff><aff id="A43"><label>43</label>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste, Italy</aff><aff id="A44"><label>44</label>University of Trieste, Trieste, Italy</aff><aff id="A45"><label>45</label>Department of Psychology, The University of Edinburgh, Edinburgh, UK</aff><aff id="A46"><label>46</label>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A47"><label>47</label>EMGO+ Institute, VU Medical Centre, Amsterdam, The Netherlands</aff><aff id="A48"><label>48</label>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK</aff><aff id="A49"><label>49</label>Department of Nutrition and Dietetics, Harokopio University, Athens, Greece</aff><aff id="A50"><label>50</label>Department of Epidemiology & Population Healths, London School of Hygiene & Tropical Medicine, UK</aff><aff id="A51"><label>51</label>National Institute for Health and Welfare, Finland</aff><aff id="A52"><label>52</label>Department of General Practice and Primary Health Care, University of Helsinki, Finland</aff><aff id="A53"><label>53</label>Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</aff><aff id="A54"><label>54</label>Folkhalsan Research Centre, Helsinki, Finland</aff><aff id="A55"><label>55</label>Vasa Central Hospital, Vasa, Finland</aff><aff id="A56"><label>56</label>Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA</aff><aff id="A57"><label>57</label>Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA</aff><aff id="A58"><label>58</label>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD, USA</aff><aff id="A59"><label>59</label>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</aff><aff id="A60"><label>60</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A61"><label>61</label>Channing Laboratory, Department of Medicine, Brigham and Women.s Hospital Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A62"><label>62</label>MRC Human Genetics Unit at the Medical Research Council Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Edinburgh, UK</aff><aff id="A63"><label>63</label>Washington University St.Louis, St. Louis, MO, USA</aff><aff id="A64"><label>64</label>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A65"><label>65</label>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA</aff><aff id="A66"><label>66</label>Diagnostic GP laboratory Eindhoven, Eindhoven, the Netherlands</aff><aff id="A67"><label>67</label>Swiss Institute of Bioinformatics, Switzerland</aff><aff id="A68"><label>68</label>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</aff><aff id="A69"><label>69</label>Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia</aff><aff id="A70"><label>70</label>Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, Erasmus MC, Rotterdam, the Netherlands</aff><aff id="A71"><label>71</label>MRC Centre for Causal Analysis in Translational Epidemiology, School of Social & Community Medicine, University of Bristol, UK</aff><aff id="A72"><label>72</label>Human genetic, Genome Institute of Singapore, Singapore</aff><aff id="A73"><label>73</label>Institute for Migration and Ethnic Studies, Zagreb, Croatia</aff><aff id="A74"><label>74</label>Department of Biostatistics, University of Washington, Seattle, WA, USA</aff><aff id="A75"><label>75</label>Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</aff><aff id="A76"><label>76</label>Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania</aff><aff id="A77"><label>77</label>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland</aff><aff id="A78"><label>78</label>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</aff><aff id="A79"><label>79</label>Genetic and Molecular Epidemiology Laboratory, McMaster University, Hamilton, ON Canada</aff><aff id="A80"><label>80</label>Amgen, Cambridge, MA USA</aff><aff id="A81"><label>81</label>Foundation Medicine, Inc., Cambridge MA USA</aff><aff id="A82"><label>82</label>Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK</aff><aff id="A83"><label>83</label>Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ, USA</aff><aff id="A84"><label>84</label>Department of Clinical Health Psychology, University of Tilburg, Tilburg, the Netherlands</aff><aff id="A85"><label>85</label>Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA USA</aff><aff id="A86"><label>86</label>Group Health Research Institute, Group Health Cooperative, Seattle, WA USA</aff><aff id="A87"><label>87</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A88"><label>88</label>Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia</aff><aff id="A89"><label>89</label>Lab Cardiovascular Sciences - NIA - NIH, Baltimore, USA</aff><aff id="A90"><label>90</label>Laboratory of Neurogenetics, National Institute of Ageing, Bethesda, MD, USA</aff><aff id="A91"><label>91</label>LifeLines Cohort Study & Biobank, University Medical Center Groningen, University of Groningen, the Netherlands</aff><aff id="A92"><label>92</label>Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK</aff><aff id="A93"><label>93</label>Cardiovascular Genetics Research Unit, EA4373, Université Henri Poincaré - Nancy 1, Nancy, France</aff><aff id="A94"><label>94</label>Department of Epidemiology, Emory University, Atlanta, GA, USA</aff><aff id="A95"><label>95</label>The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, UK</aff><aff id="A96"><label>96</label>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A97"><label>97</label>Institute of Molecular Genetics-CNR, Pavia, Italy</aff><aff id="A98"><label>98</label>Icelandic Cancer Registry, Reykjavik, Iceland</aff><aff id="A99"><label>99</label>Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</aff><aff id="A100"><label>100</label>Municipal Health Service Brabant-Zuidoost, Helmond, the Netherlands</aff><aff id="A101"><label>101</label>Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A102"><label>102</label>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital, Lausanne, Switzerland</aff><aff id="A103"><label>103</label>Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald</aff><aff id="A104"><label>104</label>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A105"><label>105</label>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A106"><label>106</label>Klinikum Grosshadern, Munich, Germany</aff><aff id="A107"><label>107</label>POZOB Veldhoven, Veldhoven, the Netherlands</aff><aff id="A108"><label>108</label>Department of Endocrinology, University Medical Center Groningen, University of Groningen, the Netherlands</aff><aff id="A109"><label>109</label>Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia</aff><aff id="A110"><label>110</label>Klinik für Gynäkologie und Geburtshilfe, Universität Greifswald, Germany</aff><aff id="A111"><label>111</label>Harvard School of Public Health, Boston, MA USA</aff><aff id="A112"><label>112</label>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A113"><label>113</label>Division of Cardiology, Brigham and Women’s Hospital, Boston, MA USA</aff><aff id="A114"><label>114</label>National Institute on Aging, Intramural Research Program, Baltimore, MD, USA</aff><aff id="A115"><label>115</label>Institut für Community Medicine, Universität Greifswald, Germany</aff><author-notes><corresp id="FN1">Corresponding authors: Anna Murray, Peninsula Medical School, St Lukes, Magdalen Road, Exeter, EX1 2LU, UK, <email>anna.murray@pms.ac.uk</email>. Kathryn L Lunetta, Department of Biostatistics, Boston University School of Public Health, 801 Mass Avenue, Crosstown Center, CT313, Boston, MA 02118, <email>klunetta@bu.edu</email></corresp><fn id="FN2"><label>*</label><p>These authors contributed jointly to this work</p></fn><fn id="FN3"><label>#</label><p>These senior authors jointly oversaw this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>22</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="collection"><month>3</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2012</year></pub-date><volume>44</volume><issue>3</issue><fpage>260</fpage><lpage>268</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.1051</pmc-comment>
<permissions><license><license-p>Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:
<uri xlink:type="simple" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</uri></license-p></license></permissions><abstract><p id="P1">To identify novel loci for age at natural menopause, we performed a meta-analysis of 22 genome-wide association studies in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 new age at natural menopause loci (<italic>P</italic> < 5 × 10<sup>−8</sup>). The new loci included genes implicated in DNA repair (<italic>EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG, PRIM1</italic>) and immune function (<italic>IL11, NLRP11, BAT2</italic>). Gene-set enrichment pathway analyses using the full GWAS dataset identified exodeoxyribonuclease, NFκB signalling and mitochondrial dysfunction as biological processes related to timing of menopause.</p></abstract></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><p><bold>a.</bold> Manhattan plot of discovery meta analysis. <bold>b.</bold> quantile-quantile plot of discovery primary analysis (red), and double genomic control adjusted primary analysis (black)</p></caption><graphic xlink:href="nihms342040f1"></graphic></fig><table-wrap id="T1" position="float" orientation="landscape"><label>Table 1</label><caption><p>Discovery and replication results</p></caption><table frame="below" rules="groups"><thead><tr><th valign="bottom" align="center" rowspan="1" colspan="1">Region number</th><th valign="bottom" align="center" rowspan="1" colspan="1">Most Significant SNP</th><th valign="bottom" align="center" rowspan="1" colspan="1">Chr</th><th valign="bottom" align="center" rowspan="1" colspan="1">Location (bp)</th><th valign="bottom" align="center" rowspan="1" colspan="1">Minor/Major</th><th valign="bottom" align="center" rowspan="1" colspan="1">Analysis</th><th valign="bottom" align="center" rowspan="1" colspan="1">MAF</th><th valign="bottom" align="center" rowspan="1" colspan="1">Effect per minor allele (years)</th><th valign="bottom" align="center" rowspan="1" colspan="1">SE</th><th valign="bottom" align="center" rowspan="1" colspan="1">P</th><th valign="bottom" align="center" rowspan="1" colspan="1">Absolute Effect per minor allele (weeks)</th><th valign="bottom" align="center" rowspan="1" colspan="1">Heterogeneity P-value</th></tr></thead><tbody><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>1a</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs4246511</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">39152972</td><td align="center" valign="top" rowspan="1" colspan="1">t/c</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.271</td><td align="center" valign="top" rowspan="1" colspan="1">0.289</td><td align="center" valign="top" rowspan="1" colspan="1">0.035</td><td align="center" valign="top" rowspan="1" colspan="1">1.02 × 10<sup>−16</sup></td><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="center" valign="top" rowspan="1" colspan="1">0.288</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.293</td><td align="center" valign="top" rowspan="1" colspan="1">0.133</td><td align="center" valign="top" rowspan="1" colspan="1">0.052</td><td align="center" valign="top" rowspan="1" colspan="1">0.01</td><td align="center" valign="top" rowspan="1" colspan="1">6.9</td><td align="center" valign="top" rowspan="1" colspan="1">0.68</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.24</td><td align="center" valign="top" rowspan="1" colspan="1">0.029</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>9.08</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>17</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">12.5</td><td align="center" valign="top" rowspan="1" colspan="1">0.012</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>1b</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs1635501</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">240107398</td><td align="center" valign="top" rowspan="1" colspan="1">c/t</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.478</td><td align="center" valign="top" rowspan="1" colspan="1">−0.188</td><td align="center" valign="top" rowspan="1" colspan="1">0.032</td><td align="center" valign="top" rowspan="1" colspan="1">4.90 × 10<sup>−09</sup></td><td align="center" valign="top" rowspan="1" colspan="1">9.8</td><td align="center" valign="top" rowspan="1" colspan="1">0.08</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.456</td><td align="center" valign="top" rowspan="1" colspan="1">−0.11</td><td align="center" valign="top" rowspan="1" colspan="1">0.048</td><td align="center" valign="top" rowspan="1" colspan="1">0.023</td><td align="center" valign="top" rowspan="1" colspan="1">5.7</td><td align="center" valign="top" rowspan="1" colspan="1">0.016</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.164</td><td align="center" valign="top" rowspan="1" colspan="1">0.027</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>8.46</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>10</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">8.5</td><td align="center" valign="top" rowspan="1" colspan="1">0.178</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>2a</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs2303369</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">27568920</td><td align="center" valign="top" rowspan="1" colspan="1">t/c</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.388</td><td align="center" valign="top" rowspan="1" colspan="1">−0.174</td><td align="center" valign="top" rowspan="1" colspan="1">0.03</td><td align="center" valign="top" rowspan="1" colspan="1">3.80 × 10<sup>−09</sup></td><td align="center" valign="top" rowspan="1" colspan="1">9</td><td align="center" valign="top" rowspan="1" colspan="1">0.639</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.391</td><td align="center" valign="top" rowspan="1" colspan="1">−0.179</td><td align="center" valign="top" rowspan="1" colspan="1">0.047</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>0.000138</italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">9.3</td><td align="center" valign="top" rowspan="1" colspan="1">0.542</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.175</td><td align="center" valign="top" rowspan="1" colspan="1">0.025</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>2.25</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>12</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">9.1</td><td align="center" valign="top" rowspan="1" colspan="1">0.927</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>2b</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs10183486</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">171699217</td><td align="center" valign="top" rowspan="1" colspan="1">t/c</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.366</td><td align="center" valign="top" rowspan="1" colspan="1">−0.219</td><td align="center" valign="top" rowspan="1" colspan="1">0.031</td><td align="center" valign="top" rowspan="1" colspan="1">7.88 × 10<sup>−13</sup></td><td align="center" valign="top" rowspan="1" colspan="1">11.4</td><td align="center" valign="top" rowspan="1" colspan="1">0.43</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.362</td><td align="center" valign="top" rowspan="1" colspan="1">−0.141</td><td align="center" valign="top" rowspan="1" colspan="1">0.047</td><td align="center" valign="top" rowspan="1" colspan="1">0.003</td><td align="center" valign="top" rowspan="1" colspan="1">7.3</td><td align="center" valign="top" rowspan="1" colspan="1">0.727</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.196</td><td align="center" valign="top" rowspan="1" colspan="1">0.026</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>2.21</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>14</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">10.2</td><td align="center" valign="top" rowspan="1" colspan="1">0.169</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>2c</bold><xref rid="TFN2" ref-type="table-fn">a</xref></td><td align="center" valign="top" rowspan="1" colspan="1">rs7606918</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">172603695</td><td align="center" valign="top" rowspan="1" colspan="1">g/a</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.161</td><td align="center" valign="top" rowspan="1" colspan="1">−0.228</td><td align="center" valign="top" rowspan="1" colspan="1">0.041</td><td align="center" valign="top" rowspan="1" colspan="1">2.89 × 10<sup>−08</sup></td><td align="center" valign="top" rowspan="1" colspan="1">11.8</td><td align="center" valign="top" rowspan="1" colspan="1">0.374</td></tr><tr><td colspan="12" align="center" valign="top" rowspan="1">Replication not attempted</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>4</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs4693089</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">84592646</td><td align="center" valign="top" rowspan="1" colspan="1">g/a</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.486</td><td align="center" valign="top" rowspan="1" colspan="1">0.209</td><td align="center" valign="top" rowspan="1" colspan="1">0.03</td><td align="center" valign="top" rowspan="1" colspan="1">3.28 × 10<sup>−12</sup></td><td align="center" valign="top" rowspan="1" colspan="1">10.9</td><td align="center" valign="top" rowspan="1" colspan="1">0.336</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.492</td><td align="center" valign="top" rowspan="1" colspan="1">0.273</td><td align="center" valign="top" rowspan="1" colspan="1">0.047</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>6.69</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>09</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">14.2</td><td align="center" valign="top" rowspan="1" colspan="1">0.298</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.228</td><td align="center" valign="top" rowspan="1" colspan="1">0.025</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>2.38</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>19</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">11.8</td><td align="center" valign="top" rowspan="1" colspan="1">0.254</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>5a</bold><xref rid="TFN3" ref-type="table-fn">b</xref></td><td align="center" valign="top" rowspan="1" colspan="1">rs890835</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">175888877</td><td align="center" valign="top" rowspan="1" colspan="1">a/c</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.112</td><td align="center" valign="top" rowspan="1" colspan="1">0.266</td><td align="center" valign="top" rowspan="1" colspan="1">0.047</td><td align="center" valign="top" rowspan="1" colspan="1">1.17 × 10<sup>−08</sup></td><td align="center" valign="top" rowspan="1" colspan="1">13.8</td><td align="center" valign="top" rowspan="1" colspan="1">0.003</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.115</td><td align="center" valign="top" rowspan="1" colspan="1">−0.037</td><td align="center" valign="top" rowspan="1" colspan="1">0.072</td><td align="center" valign="top" rowspan="1" colspan="1">0.613</td><td align="center" valign="top" rowspan="1" colspan="1">1.9</td><td align="center" valign="top" rowspan="1" colspan="1">0.486</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.177</td><td align="center" valign="top" rowspan="1" colspan="1">0.039</td><td align="center" valign="top" rowspan="1" colspan="1">6.10 × 10<sup>−06</sup></td><td align="center" valign="top" rowspan="1" colspan="1">9.2</td><td align="center" valign="top" rowspan="1" colspan="1">0.0004</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>5b</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs365132</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">176311180</td><td align="center" valign="top" rowspan="1" colspan="1">t/g</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.49</td><td align="center" valign="top" rowspan="1" colspan="1">0.275</td><td align="center" valign="top" rowspan="1" colspan="1">0.029</td><td align="center" valign="top" rowspan="1" colspan="1">1.90 × 10<sup>−21</sup></td><td align="center" valign="top" rowspan="1" colspan="1">14.3</td><td align="center" valign="top" rowspan="1" colspan="1">0.115</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.494</td><td align="center" valign="top" rowspan="1" colspan="1">0.319</td><td align="center" valign="top" rowspan="1" colspan="1">0.046</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>4.26</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>12</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">16.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.728</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.287</td><td align="center" valign="top" rowspan="1" colspan="1">0.025</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>9.11</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>32</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">14.9</td><td align="center" valign="top" rowspan="1" colspan="1">0.416</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>6a</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs2153157</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">11005474</td><td align="center" valign="top" rowspan="1" colspan="1">a/g</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.492</td><td align="center" valign="top" rowspan="1" colspan="1">0.184</td><td align="center" valign="top" rowspan="1" colspan="1">0.028</td><td align="center" valign="top" rowspan="1" colspan="1">9.40 × 10<sup>−11</sup></td><td align="center" valign="top" rowspan="1" colspan="1">9.5</td><td align="center" valign="top" rowspan="1" colspan="1">0.858</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.5</td><td align="center" valign="top" rowspan="1" colspan="1">0.116</td><td align="center" valign="top" rowspan="1" colspan="1">0.046</td><td align="center" valign="top" rowspan="1" colspan="1">0.012</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">0.329</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.165</td><td align="center" valign="top" rowspan="1" colspan="1">0.024</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>7.76</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>12</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">8.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.211</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>6b</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs1046089</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">31710946</td><td align="center" valign="top" rowspan="1" colspan="1">a/g</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.353</td><td align="center" valign="top" rowspan="1" colspan="1">−0.226</td><td align="center" valign="top" rowspan="1" colspan="1">0.031</td><td align="center" valign="top" rowspan="1" colspan="1">1.31 × 10<sup>−13</sup></td><td align="center" valign="top" rowspan="1" colspan="1">11.8</td><td align="center" valign="top" rowspan="1" colspan="1">0.426</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.358</td><td align="center" valign="top" rowspan="1" colspan="1">−0.181</td><td align="center" valign="top" rowspan="1" colspan="1">0.049</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>1.91</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>04</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">9.4</td><td align="center" valign="top" rowspan="1" colspan="1">0.732</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.213</td><td align="center" valign="top" rowspan="1" colspan="1">0.026</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>1.63</italic></bold><italic>×</italic><bold><italic>10</italic></bold><italic><sup>−</sup></italic><bold><italic><sup>16</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">11.1</td><td align="center" valign="top" rowspan="1" colspan="1">0.427</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>8</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs2517388</td><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="center" valign="top" rowspan="1" colspan="1">38096889</td><td align="center" valign="top" rowspan="1" colspan="1">g/t</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.174</td><td align="center" valign="top" rowspan="1" colspan="1">0.274</td><td align="center" valign="top" rowspan="1" colspan="1">0.04</td><td align="center" valign="top" rowspan="1" colspan="1">1.13 × 10<sup>−11</sup></td><td align="center" valign="top" rowspan="1" colspan="1">14.2</td><td align="center" valign="top" rowspan="1" colspan="1">0.67</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.189</td><td align="center" valign="top" rowspan="1" colspan="1">0.234</td><td align="center" valign="top" rowspan="1" colspan="1">0.062</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>1.52</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>04</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">12.2</td><td align="center" valign="top" rowspan="1" colspan="1">0.708</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.262</td><td align="center" valign="top" rowspan="1" colspan="1">0.034</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>9.31</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>15</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">13.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.591</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>11</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs12294104</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">30339475</td><td align="center" valign="top" rowspan="1" colspan="1">t/c</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.172</td><td align="center" valign="top" rowspan="1" colspan="1">0.226</td><td align="center" valign="top" rowspan="1" colspan="1">0.04</td><td align="center" valign="top" rowspan="1" colspan="1">1.63 × 10<sup>−08</sup></td><td align="center" valign="top" rowspan="1" colspan="1">11.8</td><td align="center" valign="top" rowspan="1" colspan="1">0.721</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.18</td><td align="center" valign="top" rowspan="1" colspan="1">0.223</td><td align="center" valign="top" rowspan="1" colspan="1">0.06</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>2.18</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>04</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">11.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.239</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.225</td><td align="center" valign="top" rowspan="1" colspan="1">0.033</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>1.46</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>11</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">11.7</td><td align="center" valign="top" rowspan="1" colspan="1">0.97</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>12</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs2277339</td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">55432336</td><td align="center" valign="top" rowspan="1" colspan="1">g/t</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.102</td><td align="center" valign="top" rowspan="1" colspan="1">−0.394</td><td align="center" valign="top" rowspan="1" colspan="1">0.051</td><td align="center" valign="top" rowspan="1" colspan="1">5.99 × 10<sup>−15</sup></td><td align="center" valign="top" rowspan="1" colspan="1">20.5</td><td align="center" valign="top" rowspan="1" colspan="1">0.088</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.105</td><td align="center" valign="top" rowspan="1" colspan="1">−0.347</td><td align="center" valign="top" rowspan="1" colspan="1">0.077</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>6.89</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>06</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">18</td><td align="center" valign="top" rowspan="1" colspan="1">0.765</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.38</td><td align="center" valign="top" rowspan="1" colspan="1">0.042</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>2.47</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>19</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">19.7</td><td align="center" valign="top" rowspan="1" colspan="1">0.61</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>13a</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs3736830</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">49204222</td><td align="center" valign="top" rowspan="1" colspan="1">g/c</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.157</td><td align="center" valign="top" rowspan="1" colspan="1">−0.243</td><td align="center" valign="top" rowspan="1" colspan="1">0.04</td><td align="center" valign="top" rowspan="1" colspan="1">1.75 <italic>×</italic> 10<sup>−09</sup></td><td align="center" valign="top" rowspan="1" colspan="1">12.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.859</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.165</td><td align="center" valign="top" rowspan="1" colspan="1">−0.033</td><td align="center" valign="top" rowspan="1" colspan="1">0.062</td><td align="center" valign="top" rowspan="1" colspan="1">0.594</td><td align="center" valign="top" rowspan="1" colspan="1">1.7</td><td align="center" valign="top" rowspan="1" colspan="1">0.905</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.18</td><td align="center" valign="top" rowspan="1" colspan="1">0.034</td><td align="center" valign="top" rowspan="1" colspan="1">9.41 × 10<sup>−08</sup></td><td align="center" valign="top" rowspan="1" colspan="1">9.4</td><td align="center" valign="top" rowspan="1" colspan="1">0.005</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>13b</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs4886238</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">60011740</td><td align="center" valign="top" rowspan="1" colspan="1">a/g</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.334</td><td align="center" valign="top" rowspan="1" colspan="1">0.172</td><td align="center" valign="top" rowspan="1" colspan="1">0.031</td><td align="center" valign="top" rowspan="1" colspan="1">3.76 × 10<sup>−08</sup></td><td align="center" valign="top" rowspan="1" colspan="1">8.9</td><td align="center" valign="top" rowspan="1" colspan="1">0.974</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.333</td><td align="center" valign="top" rowspan="1" colspan="1">0.166</td><td align="center" valign="top" rowspan="1" colspan="1">0.049</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>6.09</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>04</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">8.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.953</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.17</td><td align="center" valign="top" rowspan="1" colspan="1">0.026</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>9.53</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>11</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">8.9</td><td align="center" valign="top" rowspan="1" colspan="1">0.919</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>15</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs2307449</td><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="center" valign="top" rowspan="1" colspan="1">87664932</td><td align="center" valign="top" rowspan="1" colspan="1">g/t</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.405</td><td align="center" valign="top" rowspan="1" colspan="1">−0.167</td><td align="center" valign="top" rowspan="1" colspan="1">0.03</td><td align="center" valign="top" rowspan="1" colspan="1">2.59 × 10<sup>−08</sup></td><td align="center" valign="top" rowspan="1" colspan="1">8.7</td><td align="center" valign="top" rowspan="1" colspan="1">0.442</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.387</td><td align="center" valign="top" rowspan="1" colspan="1">−0.225</td><td align="center" valign="top" rowspan="1" colspan="1">0.047</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>1.61</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>06</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">11.7</td><td align="center" valign="top" rowspan="1" colspan="1">0.328</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.184</td><td align="center" valign="top" rowspan="1" colspan="1">0.025</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>3.56</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>13</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">9.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.294</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>16</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs10852344</td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1">11924420</td><td align="center" valign="top" rowspan="1" colspan="1">c/t</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.415</td><td align="center" valign="top" rowspan="1" colspan="1">0.198</td><td align="center" valign="top" rowspan="1" colspan="1">0.029</td><td align="center" valign="top" rowspan="1" colspan="1">1.28 × 10<sup>−11</sup></td><td align="center" valign="top" rowspan="1" colspan="1">10.3</td><td align="center" valign="top" rowspan="1" colspan="1">0.014</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.426</td><td align="center" valign="top" rowspan="1" colspan="1">0.093</td><td align="center" valign="top" rowspan="1" colspan="1">0.046</td><td align="center" valign="top" rowspan="1" colspan="1">0.042</td><td align="center" valign="top" rowspan="1" colspan="1">4.8</td><td align="center" valign="top" rowspan="1" colspan="1">0.599</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.168</td><td align="center" valign="top" rowspan="1" colspan="1">0.025</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>1.01</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>11</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">8.7</td><td align="center" valign="top" rowspan="1" colspan="1">0.054</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>19a</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs11668344</td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="center" valign="top" rowspan="1" colspan="1">60525476</td><td align="center" valign="top" rowspan="1" colspan="1">g/a</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.363</td><td align="center" valign="top" rowspan="1" colspan="1">−0.416</td><td align="center" valign="top" rowspan="1" colspan="1">0.03</td><td align="center" valign="top" rowspan="1" colspan="1">5.94 × 10<sup>−43</sup></td><td align="center" valign="top" rowspan="1" colspan="1">21.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.112</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.36</td><td align="center" valign="top" rowspan="1" colspan="1">−0.415</td><td align="center" valign="top" rowspan="1" colspan="1">0.048</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>2.65</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>18</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">21.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.517</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.416</td><td align="center" valign="top" rowspan="1" colspan="1">0.026</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>1.45</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>59</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">21.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.987</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>19b</bold><xref rid="TFN4" ref-type="table-fn">c</xref></td><td align="center" valign="top" rowspan="1" colspan="1">rs12461110</td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="center" valign="top" rowspan="1" colspan="1">61012475</td><td align="center" valign="top" rowspan="1" colspan="1">a/g</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.356</td><td align="center" valign="top" rowspan="1" colspan="1">−0.174</td><td align="center" valign="top" rowspan="1" colspan="1">0.03</td><td align="center" valign="top" rowspan="1" colspan="1">9.49 × 10<sup>−09</sup></td><td align="center" valign="top" rowspan="1" colspan="1">9.1</td><td align="center" valign="top" rowspan="1" colspan="1">0.835</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.344</td><td align="center" valign="top" rowspan="1" colspan="1">−0.117</td><td align="center" valign="top" rowspan="1" colspan="1">0.049</td><td align="center" valign="top" rowspan="1" colspan="1">0.018</td><td align="center" valign="top" rowspan="1" colspan="1">6.1</td><td align="center" valign="top" rowspan="1" colspan="1">0.542</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">−0.158</td><td align="center" valign="top" rowspan="1" colspan="1">0.026</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>8.74</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>10</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">8.2</td><td align="center" valign="top" rowspan="1" colspan="1">0.32</td></tr><tr><td colspan="12" valign="bottom" align="left" rowspan="1"><hr></hr></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"><bold>20</bold></td><td align="center" valign="top" rowspan="1" colspan="1">rs16991615</td><td align="center" valign="top" rowspan="1" colspan="1">20</td><td align="center" valign="top" rowspan="1" colspan="1">5896227</td><td align="center" valign="top" rowspan="1" colspan="1">a/g</td><td align="center" valign="top" rowspan="1" colspan="1">Discovery</td><td align="center" valign="top" rowspan="1" colspan="1">0.069</td><td align="center" valign="top" rowspan="1" colspan="1">0.971</td><td align="center" valign="top" rowspan="1" colspan="1">0.062</td><td align="center" valign="top" rowspan="1" colspan="1">1.16 × 10<sup>−54</sup></td><td align="center" valign="top" rowspan="1" colspan="1">50.5</td><td align="center" valign="top" rowspan="1" colspan="1">0.356</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Replication</td><td align="center" valign="top" rowspan="1" colspan="1">0.07</td><td align="center" valign="top" rowspan="1" colspan="1">0.896</td><td align="center" valign="top" rowspan="1" colspan="1">0.096</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>7.90</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>21</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">46.6</td><td align="center" valign="top" rowspan="1" colspan="1">0.088</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">Combined</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">0.948</td><td align="center" valign="top" rowspan="1" colspan="1">0.052</td><td align="center" valign="top" rowspan="1" colspan="1"><bold><italic>1.42</italic></bold><italic>×</italic><bold><italic>10</italic></bold><sup>−</sup><bold><italic><sup>73</sup></italic></bold></td><td align="center" valign="top" rowspan="1" colspan="1">49.3</td><td align="center" valign="top" rowspan="1" colspan="1">0.509</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><p>MAF: minor allele frequency; Heterogeneity: p-values for heterogeneity among discovery studies, replication studies, and comparing all discovery to all replication studies. P- value: Replication p-values that meet the criterion P<0.05/19 are indicated in bold italics. Combined analysis p-values that reached genome-wide significance are indicated in bold italics.</p></fn><fn id="TFN2"><label>a</label><p>Conditional analysis: beta(SE): −0.199(0.041); p-value:9.8 × 10<sup>−07</sup></p></fn><fn id="TFN3"><label>b</label><p>Conditional analysis beta(SE): 0.267(0.046); p-value:6.5 × 10<sup>−09</sup></p></fn><fn id="TFN4"><label>c</label><p>Conditional analysis: beta(SE): −0.168(0.031); p-value:3.8 × 10<sup>−08</sup></p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float" orientation="landscape"><label>Table 2</label><caption><p>Characteristics of the top SNP in each region.</p></caption><table frame="below" rules="groups"><thead><tr><th valign="bottom" align="center" rowspan="1" colspan="1">Region</th><th valign="bottom" align="center" rowspan="1" colspan="1">SNPID</th><th valign="bottom" align="center" rowspan="1" colspan="1">Chr</th><th valign="bottom" align="right" rowspan="1" colspan="1">Location (bp)</th><th valign="bottom" align="center" rowspan="1" colspan="1">gene</th><th valign="bottom" align="center" rowspan="1" colspan="1">feature</th><th valign="bottom" align="left" rowspan="1" colspan="1">Other refgenes<60kb from SNP</th><th valign="bottom" align="left" rowspan="1" colspan="1">Genes with SNPs in LD (r<sup>2</sup>>0.5) with SNP (gene:r<sup>2</sup>)</th><th valign="bottom" align="left" rowspan="1" colspan="1">eQTL</th></tr></thead><tbody><tr><td align="center" valign="top" rowspan="1" colspan="1">1a</td><td align="center" valign="top" rowspan="1" colspan="1">rs4246511</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="right" valign="top" rowspan="1" colspan="1">39,152,972</td><td align="center" valign="top" rowspan="1" colspan="1">RHBDL2</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">MYCBP;GJA10;RRAGC</td><td align="left" valign="top" rowspan="1" colspan="1">MYCBP:0.678; RHBDL2:0.678; RRAGC:0.678; GJA9:0.678; LOC100130627:0.678</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">1b</td><td align="center" valign="top" rowspan="1" colspan="1">rs1635501</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="right" valign="top" rowspan="1" colspan="1">240,107,398</td><td align="center" valign="top" rowspan="1" colspan="1">EXO1</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">LOC100131576:0.678; WDR64:0.923; LOC100133057:1; EXO1:1</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">2a</td><td align="center" valign="top" rowspan="1" colspan="1">rs2303369</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="right" valign="top" rowspan="1" colspan="1">27,568,920</td><td align="center" valign="top" rowspan="1" colspan="1">FNDC4</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">GCKR;KRTCAP3;IFT172;N RBP1</td><td align="left" valign="top" rowspan="1" colspan="1">FTHL3P:0.967; GCKR:1; GTF3C2:0.967; MPV17:0.967; PPM1G:0.967; UCN:0.841; EIF2B4:0.967; SNX17:0.967; IFT172:1; NRBP1:0.967; TRIM54:0.841; FNDC4:1; C2orf16:0.513; ZNF513:0.967; KRTCAP3:1; DNAJC5G:0.841; LOC100130981:0.901</td><td align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup>>0.9 with multiple eSNPs for IFT172n lymph, adipose, and blood; r2>0.9 with multiple eSNPs for KRTCAP3 in lymph and CD4; r2>0.9 with eSNP for SNX17 in PFC</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">2b</td><td align="center" valign="top" rowspan="1" colspan="1">rs10183486</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="right" valign="top" rowspan="1" colspan="1">171,699,217</td><td align="center" valign="top" rowspan="1" colspan="1">TLK1</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">GORASP2:0.929; TLK1:0.964</td><td align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup>>0.9 with eSNPs for TLK1 in LCL and PFC</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">rs4693089</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="right" valign="top" rowspan="1" colspan="1">84,592,646</td><td align="center" valign="top" rowspan="1" colspan="1">HELQ</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">MRPS18C;FAM175A</td><td align="left" valign="top" rowspan="1" colspan="1">MRPS18C:1; FAM175A:1; AGPAT9:1; HEL308:1; OK/SW-CL.36:1</td><td align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup>>0.80 with eSNPs for MRPS18C in Lymph and PFC; r<sup>2</sup>>0.80 for AGPAT9 in Fibroblast</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">5a</td><td align="center" valign="top" rowspan="1" colspan="1">rs890835</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="right" valign="top" rowspan="1" colspan="1">175,888,877</td><td align="center" valign="top" rowspan="1" colspan="1">RNF44</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">UBXD8;PCLKC</td><td align="left" valign="top" rowspan="1" colspan="1">SNCB:0.318; RNF44:1; FAF2:1; PCDH24:1</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">5b</td><td align="center" valign="top" rowspan="1" colspan="1">rs365132</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="right" valign="top" rowspan="1" colspan="1">176,311,180</td><td align="center" valign="top" rowspan="1" colspan="1">UIMC1</td><td align="center" valign="top" rowspan="1" colspan="1">coding-synonymous</td><td align="left" valign="top" rowspan="1" colspan="1">HK3</td><td align="left" valign="top" rowspan="1" colspan="1">FGFR4:0.871; HK3:0.967; ZNF346:0.966; UIMC1:0.967; UNC5A:0.932</td><td align="left" valign="top" rowspan="1" colspan="1">eSNP for Hs.484258 in Lymph; for FGFR4 and ZNF346 in PFC; for ZNF346 in VC</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">6a</td><td align="center" valign="top" rowspan="1" colspan="1">rs2153157</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="right" valign="top" rowspan="1" colspan="1">11,005,474</td><td align="center" valign="top" rowspan="1" colspan="1">SYCP2L</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">GCM2</td><td align="left" valign="top" rowspan="1" colspan="1">MAK:0.602; GCM2:0.602; SYCP2L:0.602</td><td align="left" valign="top" rowspan="1" colspan="1">eSNP for SYCP2L in monocytes</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">6b</td><td align="center" valign="top" rowspan="1" colspan="1">rs1046089<xref rid="TFN5" ref-type="table-fn">a</xref></td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="right" valign="top" rowspan="1" colspan="1">31,710,946</td><td align="center" valign="top" rowspan="1" colspan="1">BAT2</td><td align="center" valign="top" rowspan="1" colspan="1">missense</td><td align="left" valign="top" rowspan="1" colspan="1">BAT3;LST1;C6orf47;APOM; AIF1; NCR3; LY6G5C;LTB;BAT5;CSNK2 B;LY6G5B;BAT4;TNF</td><td align="left" valign="top" rowspan="1" colspan="1">AIF1:0.963; CLIC1:0.682; CSNK2B:0.963; HSPA1A:0.649; HSPA1B:0.587; HSPA1L:0.649; LTB:0.963; MSH5:0.682; NEU1:0.587; VARS:0.682; BAT2:0.963; BAT3:0.963; BAT4:0.963; BAT5:0.963; LST1:0.963; DDAH2:0.682; SNORD52:0.587; SNORD48:0.587; C6orf48:0.587; APOM:0.963; LSM2:0.649; C6orf47:0.963; LY6G5B:0.963; LY6G6D:0.963; LY6G6E:0.963; SLC44A4:0.587; C6orf27:0.682; C6orf25:0.682; LY6G6C:0.961; LY6G5C:0.963; NCR3:0.963; LY6G6F:0.963; C6orf26:0.682; SNORA38:0.963; LOC100130756:0.963</td><td align="left" valign="top" rowspan="1" colspan="1">eSNP for LY6G5C in CD4 and Lymph; for HLA-DRB4 in monocytes; for C6orf10 in VC; for AIF1 in Lymph; for HLA-DQA1 in LCL</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="center" valign="top" rowspan="1" colspan="1">rs2517388</td><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="right" valign="top" rowspan="1" colspan="1">38,096,889</td><td align="center" valign="top" rowspan="1" colspan="1">ASH2L</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">BAG4;EIF4EBP1;LSM1;ST AR</td><td align="left" valign="top" rowspan="1" colspan="1">STAR:0.831; ASH2L:0.831; LSM1:0.831</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">rs12294104</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="right" valign="top" rowspan="1" colspan="1">30,339,475</td><td align="center" valign="top" rowspan="1" colspan="1">--</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">MPPED2;C11orf46</td><td align="left" valign="top" rowspan="1" colspan="1">FSHB:0.92; C11orf46:1</td><td align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup>>0.9 with eSNP for C11orf46 in Lymph</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">rs2277339<xref rid="TFN6" ref-type="table-fn">b</xref></td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="right" valign="top" rowspan="1" colspan="1">55,432,336</td><td align="center" valign="top" rowspan="1" colspan="1">PRIM1</td><td align="center" valign="top" rowspan="1" colspan="1">missense</td><td align="left" valign="top" rowspan="1" colspan="1">HSD17B6;NACA</td><td align="left" valign="top" rowspan="1" colspan="1">-</td><td align="left" valign="top" rowspan="1" colspan="1">eSNP for PRIM1 in VC, CR, PFC</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">13a</td><td align="center" valign="top" rowspan="1" colspan="1">rs3736830</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="right" valign="top" rowspan="1" colspan="1">49,204,222</td><td align="center" valign="top" rowspan="1" colspan="1">KPNA3</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">EBPL</td><td align="left" valign="top" rowspan="1" colspan="1">KPNA3:0.734; EBPL:0.734; ARL11:0.623; LOC100131941:0.623</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">13b</td><td align="center" valign="top" rowspan="1" colspan="1">rs4886238</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="right" valign="top" rowspan="1" colspan="1">60,011,740</td><td align="center" valign="top" rowspan="1" colspan="1">TDRD3</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">TDRD3:1; LOC390407:0.731</td><td align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup>>0.8 with eSNP in Adipose for TDRD3</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="center" valign="top" rowspan="1" colspan="1">rs2307449</td><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="right" valign="top" rowspan="1" colspan="1">87,664,932</td><td align="center" valign="top" rowspan="1" colspan="1">POLG</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">FANCI</td><td align="left" valign="top" rowspan="1" colspan="1">POLG:0.965; RLBP1:0.898; ABHD2:0.898; FANCI:0.965; LOC728003:0.898; LOC100131654:0.683</td><td align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup>>0.8 with eSNP for RLBP1 in PFC</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1">rs10852344</td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="right" valign="top" rowspan="1" colspan="1">11,924,420</td><td align="center" valign="top" rowspan="1" colspan="1">--</td><td align="center" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">TNFRSF17;RUNDC2A;GSP T1</td><td align="left" valign="top" rowspan="1" colspan="1">TNFRSF17:0.662; GSPT1:1; COX6CP1:1; RSL1D1:1; ZC3H7A:0.701; RUNDC2A:0.662; LOC729978:1</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">19a</td><td align="center" valign="top" rowspan="1" colspan="1">rs11668344</td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="right" valign="top" rowspan="1" colspan="1">60,525,476</td><td align="center" valign="top" rowspan="1" colspan="1">TMEM150B</td><td align="center" valign="top" rowspan="1" colspan="1">intron</td><td align="left" valign="top" rowspan="1" colspan="1">BRSK1;HSPBP1;COX6B2;L OC284417;IL11; SUV420H2</td><td align="left" valign="top" rowspan="1" colspan="1">IL11:0.962; SAPS1:0.894; HSPBP1:0.962; BRSK1:0.962; SUV420H2:0.962; COX6B2:0.962; LOC284417:0.962; FAM71E2:0.962</td><td align="left" valign="top" rowspan="1" colspan="1">r<sup>2</sup>>0.8 with eSNP for MGC2705 in adipose and blood</td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">19b</td><td align="center" valign="top" rowspan="1" colspan="1">rs12461110<xref rid="TFN7" ref-type="table-fn">c</xref></td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="right" valign="top" rowspan="1" colspan="1">61,012,475</td><td align="center" valign="top" rowspan="1" colspan="1">NLRP11</td><td align="center" valign="top" rowspan="1" colspan="1">missense</td><td align="left" valign="top" rowspan="1" colspan="1">NLRP4</td><td align="left" valign="top" rowspan="1" colspan="1">NLRP4:0.514; NLRP11:0.514; RFPL4A:0.514; LOC646663:0.514; LOC729974:0.514</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="top" rowspan="1" colspan="1">20</td><td align="center" valign="top" rowspan="1" colspan="1">rs16991615<xref rid="TFN8" ref-type="table-fn">d</xref></td><td align="center" valign="top" rowspan="1" colspan="1">20</td><td align="right" valign="top" rowspan="1" colspan="1">5,896,227</td><td align="center" valign="top" rowspan="1" colspan="1">MCM8</td><td align="center" valign="top" rowspan="1" colspan="1">missense</td><td align="left" valign="top" rowspan="1" colspan="1">CRLS1;CHGB;TRMT6</td><td align="left" valign="top" rowspan="1" colspan="1">-</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="TFN5"><label>a</label><p>Arg > His; Predicted to be Damaging (SIFT), Benign (Polyphen2)</p></fn><fn id="TFN6"><label>b</label><p>Asp > Ala; Predicted to be Damaging (SIFT), Probably damaging (Polyphen2)</p></fn><fn id="TFN7"><label>c</label><p>Pro > Leu; Predicted to be Damaging (SIFT), Benign (Polyphen2)</p></fn><fn id="TFN8"><label>d</label><p>Glu > Lys; Predicted to be Tolerated (SIFT), Benign (Polyphen2)</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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