Obesity and the Microvasculature: A Systematic Review and Meta-Analysis
Identifieur interne : 002912 ( Pmc/Curation ); précédent : 002911; suivant : 002913Obesity and the Microvasculature: A Systematic Review and Meta-Analysis
Auteurs : Adrien Boillot [France] ; Sophia Zoungas [Australie] ; Paul Mitchell [Australie] ; Ronald Klein [États-Unis] ; Barbara Klein [États-Unis] ; Mohammad Kamran Ikram [Singapour, Pays-Bas] ; Caroline Klaver [Pays-Bas] ; Jie Jin Wang [Australie] ; Bamini Gopinath [Australie] ; E. Shyong Tai [Singapour] ; Aljoscha Steffen Neubauer [Allemagne] ; Serge Hercberg [France] ; Laima Brazionis [Australie] ; Seang-Mei Saw [Singapour] ; Tien-Yin Wong [Singapour] ; Sébastien Czernichow [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.
Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m2 increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.
Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.
Url:
DOI: 10.1371/journal.pone.0052708
PubMed: 23405065
PubMed Central: 3566162
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last="Zoungas">Sophia Zoungas</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Barbara" sort="Klein, Barbara" uniqKey="Klein B" first="Barbara" last="Klein">Barbara Klein</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Ikram, Mohammad Kamran" sort="Ikram, Mohammad Kamran" uniqKey="Ikram M" first="Mohammad Kamran" last="Ikram">Mohammad Kamran Ikram</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Klaver, Caroline" sort="Klaver, Caroline" uniqKey="Klaver C" first="Caroline" last="Klaver">Caroline Klaver</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Gopinath, Bamini" sort="Gopinath, Bamini" uniqKey="Gopinath B" first="Bamini" last="Gopinath">Bamini Gopinath</name><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Department of Medicine, University of Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E. Shyong" last="Tai">E. Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Neubauer, Aljoscha Steffen" sort="Neubauer, Aljoscha Steffen" uniqKey="Neubauer A" first="Aljoscha Steffen" last="Neubauer">Aljoscha Steffen Neubauer</name><affiliation wicri:level="1"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Ludwig-Maximilians University, Muenchen, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, Ludwig-Maximilians University, Muenchen</wicri:regionArea></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Unité de Recherche en Épidémiologie Nutritionnelle, Institut National de la Recherche Agronomique/Institut National de la Recherche et de la Santé Médicale, Unité U557/Avicenne Hospital/Conservatoire des Arts et Métiers/Université Paris 13/Université Sorbone Paris Cité, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche en Épidémiologie Nutritionnelle, Institut National de la Recherche Agronomique/Institut National de la Recherche et de la Santé Médicale, Unité U557/Avicenne Hospital/Conservatoire des Arts et Métiers/Université Paris 13/Université Sorbone Paris Cité, Bobigny</wicri:regionArea></affiliation></author><author><name sortKey="Brazionis, Laima" sort="Brazionis, Laima" uniqKey="Brazionis L" first="Laima" last="Brazionis">Laima Brazionis</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Department of Nutrition, Université Versailles St-Quentin, Versailles, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Université Versailles St-Quentin, Versailles</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Institut National de la Recherche et de la Santé Médicale, Unité 1018, Centre for Research in Epidemiology and Population Health, Population-based Cohorts Research Platform, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Recherche et de la Santé Médicale, Unité 1018, Centre for Research in Epidemiology and Population Health, Population-based Cohorts Research Platform, Villejuif</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno 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xml:lang="fr">France</country><wicri:regionArea>Department of Periodontology, University Paris 7, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt</wicri:regionArea></affiliation></author><author><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Barbara" sort="Klein, Barbara" uniqKey="Klein B" first="Barbara" last="Klein">Barbara Klein</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Ikram, Mohammad Kamran" sort="Ikram, Mohammad Kamran" uniqKey="Ikram M" first="Mohammad Kamran" last="Ikram">Mohammad Kamran Ikram</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Klaver, Caroline" sort="Klaver, Caroline" uniqKey="Klaver C" first="Caroline" last="Klaver">Caroline Klaver</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Gopinath, Bamini" sort="Gopinath, Bamini" uniqKey="Gopinath B" first="Bamini" last="Gopinath">Bamini Gopinath</name><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Department of Medicine, University of Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, University of Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E. Shyong" last="Tai">E. Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Neubauer, Aljoscha Steffen" sort="Neubauer, Aljoscha Steffen" uniqKey="Neubauer A" first="Aljoscha Steffen" last="Neubauer">Aljoscha Steffen Neubauer</name><affiliation wicri:level="1"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Ludwig-Maximilians University, Muenchen, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, Ludwig-Maximilians University, Muenchen</wicri:regionArea></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Unité de Recherche en Épidémiologie Nutritionnelle, Institut National de la Recherche Agronomique/Institut National de la Recherche et de la Santé Médicale, Unité U557/Avicenne Hospital/Conservatoire des Arts et Métiers/Université Paris 13/Université Sorbone Paris Cité, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche en Épidémiologie Nutritionnelle, Institut National de la Recherche Agronomique/Institut National de la Recherche et de la Santé Médicale, Unité U557/Avicenne Hospital/Conservatoire des Arts et Métiers/Université Paris 13/Université Sorbone Paris Cité, Bobigny</wicri:regionArea></affiliation></author><author><name sortKey="Brazionis, Laima" sort="Brazionis, Laima" uniqKey="Brazionis L" first="Laima" last="Brazionis">Laima Brazionis</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Department of Nutrition, Université Versailles St-Quentin, Versailles, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Université Versailles St-Quentin, Versailles</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Institut National de la Recherche et de la Santé Médicale, Unité 1018, Centre for Research in Epidemiology and Population Health, Population-based Cohorts Research Platform, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Recherche et de la Santé Médicale, Unité 1018, Centre for Research in Epidemiology and Population Health, Population-based Cohorts Research Platform, Villejuif</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.</p></sec><sec><title>Methods and Findings</title><p>Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m<sup>2</sup> increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.</p></sec><sec><title>Conclusions</title><p>Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fortunato, G" uniqKey="Fortunato G">G Fortunato</name></author><author><name sortKey="Rubba, P" uniqKey="Rubba P">P Rubba</name></author><author><name sortKey="Panico, S" uniqKey="Panico S">S Panico</name></author><author><name sortKey="Trono, D" uniqKey="Trono D">D Trono</name></author><author><name sortKey="Tinto, N" uniqKey="Tinto N">N Tinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kotsis, Vt" uniqKey="Kotsis V">VT Kotsis</name></author><author><name sortKey="Stabouli, Sv" uniqKey="Stabouli S">SV Stabouli</name></author><author><name sortKey="Papamichael, Cm" uniqKey="Papamichael C">CM Papamichael</name></author><author><name sortKey="Zakopoulos, Na" uniqKey="Zakopoulos N">NA 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23405065</article-id><article-id pub-id-type="pmc">3566162</article-id><article-id pub-id-type="publisher-id">PONE-D-12-25063</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0052708</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Cardiovascular</subject><subj-group><subject>Vascular Biology</subject></subj-group></subj-group><subj-group><subject>Clinical Research Design</subject><subj-group><subject>Meta-Analyses</subject><subject>Systematic Reviews</subject></subj-group></subj-group><subj-group><subject>Epidemiology</subject><subj-group><subject>Cardiovascular Disease Epidemiology</subject></subj-group></subj-group><subj-group><subject>Nutrition</subject><subj-group><subject>Obesity</subject></subj-group></subj-group><subj-group><subject>Ophthalmology</subject><subj-group><subject>Retinal Disorders</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Obesity and the Microvasculature: A Systematic Review and Meta-Analysis</article-title><alt-title alt-title-type="running-head">Obesity and Retinal Microvasculature</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Boillot</surname><given-names>Adrien</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zoungas</surname><given-names>Sophia</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Klein</surname><given-names>Ronald</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Klein</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ikram</surname><given-names>Mohammad Kamran</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Klaver</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jie Jin</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gopinath</surname><given-names>Bamini</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tai</surname><given-names>E. Shyong</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Neubauer</surname><given-names>Aljoscha Steffen</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hercberg</surname><given-names>Serge</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brazionis</surname><given-names>Laima</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Saw</surname><given-names>Seang-Mei</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Tien-Yin</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Czernichow</surname><given-names>Sébastien</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff12"><sup>12</sup></xref><xref ref-type="aff" rid="aff13"><sup>13</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref><on-behalf-of>for the META-EYE Study Group</on-behalf-of></contrib><contrib contrib-type="author"><collab>META-EYE Study Group</collab><xref ref-type="author-notes" rid="fn1">¶</xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Periodontology, University Paris 7, Paris, France</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria, Australia</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney, Australia</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</addr-line></aff><aff id="aff7"><label>7</label><addr-line>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff8"><label>8</label><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></aff><aff id="aff9"><label>9</label><addr-line>Department of Medicine, University of Melbourne, Victoria, Australia</addr-line></aff><aff id="aff10"><label>10</label><addr-line>Department of Ophthalmology, Ludwig-Maximilians University, Muenchen, Germany</addr-line></aff><aff id="aff11"><label>11</label><addr-line>Unité de Recherche en Épidémiologie Nutritionnelle, Institut National de la Recherche Agronomique/Institut National de la Recherche et de la Santé Médicale, Unité U557/Avicenne Hospital/Conservatoire des Arts et Métiers/Université Paris 13/Université Sorbone Paris Cité, Bobigny, France</addr-line></aff><aff id="aff12"><label>12</label><addr-line>Department of Nutrition, Université Versailles St-Quentin, Versailles, France</addr-line></aff><aff id="aff13"><label>13</label><addr-line>Institut National de la Recherche et de la Santé Médicale, Unité 1018, Centre for Research in Epidemiology and Population Health, Population-based Cohorts Research Platform, Villejuif, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Zheng</surname><given-names>Yingfeng</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Zhongshan Ophthalmic Center, China</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>sebastien.czernichow@apr.aphp.fr</email></corresp><fn id="fn1" fn-type="other"><p>¶ Members of the META-EYE Collaboration are listed in the Acknowledgments.</p></fn><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: AB SZ TYW SC. Performed the experiments: PM RK BK MKI CK JJW BG EST ASN SH LB SMS. Analyzed the data: AB SC. Wrote the paper: AB SC TYW SZ.</p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>6</day><month>2</month><year>2013</year></pub-date><volume>8</volume><issue>2</issue><elocation-id>e52708</elocation-id><history><date date-type="received"><day>20</day><month>8</month><year>2012</year></date><date date-type="accepted"><day>20</day><month>11</month><year>2012</year></date></history><permissions><copyright-year>2013</copyright-year><copyright-holder>Boillot et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.</p></sec><sec><title>Methods and Findings</title><p>Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m<sup>2</sup> increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.</p></sec><sec><title>Conclusions</title><p>Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.</p></sec></abstract><funding-group><funding-statement>Funding was provided by the National Health and Medical Research Council (#124317, #396414, #209057), the National Heart Foundation, and the Centre for Clinical Research Excellence in Clinical Science in Diabetes. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="9"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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