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Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

Identifieur interne : 002751 ( Pmc/Curation ); précédent : 002750; suivant : 002752

Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

Auteurs : Yan Guo [États-Unis] ; Shaneda Warren Andersen [États-Unis] ; Xiao-Ou Shu [États-Unis] ; Kyriaki Michailidou [Royaume-Uni] ; Manjeet K. Bolla [Royaume-Uni] ; Qin Wang [Royaume-Uni] ; Montserrat Garcia-Closas [Royaume-Uni] ; Roger L. Milne [Australie] ; Marjanka K. Schmidt [Pays-Bas] ; Jenny Chang-Claude [Allemagne] ; Allison Dunning [Royaume-Uni] ; Stig E. Bojesen [Danemark] ; Habibul Ahsan [États-Unis] ; Kristiina Aittom Ki [Finlande] ; Irene L. Andrulis [Canada] ; Hoda Anton-Culver [États-Unis] ; Volker Arndt [Allemagne] ; Matthias W. Beckmann [États-Unis] ; Alicia Beeghly-Fadiel [États-Unis] ; Javier Benitez [Espagne] ; Natalia V. Bogdanova [Allemagne] ; Bernardo Bonanni [Italie] ; Anne-Lise B Rresen-Dale [Norvège] ; Judith Brand [Suède] ; Hiltrud Brauch [Allemagne] ; Hermann Brenner [Allemagne] ; Thomas Brüning [Allemagne] ; Barbara Burwinkel [Allemagne] ; Graham Casey [États-Unis] ; Georgia Chenevix-Trench [Australie] ; Fergus J. Couch [États-Unis] ; Angela Cox [Royaume-Uni] ; Simon S. Cross [Royaume-Uni] ; Kamila Czene [Suède] ; Peter Devilee [Pays-Bas] ; Thilo Dörk [Allemagne] ; Martine Dumont [Canada] ; Peter A. Fasching [Allemagne, États-Unis] ; Jonine Figueroa [États-Unis] ; Dieter Flesch-Janys [Allemagne] ; Olivia Fletcher [Royaume-Uni] ; Henrik Flyger [Danemark] ; Florentia Fostira [Grèce] ; Marilie Gammon [États-Unis] ; Graham G. Giles [Australie] ; Pascal Guénel [France] ; Christopher A. Haiman [États-Unis] ; Ute Hamann [Allemagne] ; Maartje J. Hooning [Pays-Bas] ; John L. Hopper [Australie] ; Anna Jakubowska [Pologne] ; Farzana Jasmine [États-Unis] ; Mark Jenkins [Australie] ; Esther M. John [États-Unis] ; Nichola Johnson [Royaume-Uni] ; Michael E. Jones [Royaume-Uni] ; Maria Kabisch [Allemagne] ; Muhammad Kibriya [États-Unis] ; Julia A. Knight [Canada] ; Linetta B. Koppert [Pays-Bas] ; Veli-Matti Kosma [Finlande] ; Vessela Kristensen [Norvège] ; Loic Le Marchand [États-Unis] ; Eunjung Lee [États-Unis] ; Jingmei Li [Suède] ; Annika Lindblom [Suède] ; Robert Luben [Royaume-Uni] ; Jan Lubinski [Pologne] ; Kathi E. Malone [États-Unis] ; Arto Mannermaa [Finlande] ; Sara Margolin [Suède] ; Frederik Marme [Allemagne] ; Catriona Mclean [Australie] ; Hanne Meijers-Heijboer [Pays-Bas] ; Alfons Meindl [Allemagne] ; Susan L. Neuhausen [États-Unis] ; Heli Nevanlinna [Finlande] ; Patrick Neven [Belgique] ; Janet E. Olson [États-Unis] ; Jose I. A. Perez [Espagne] ; Barbara Perkins [Royaume-Uni] ; Paolo Peterlongo [Italie] ; Kelly-Anne Phillips [Australie] ; Katri Pylk S [Finlande] ; Anja Rudolph [Allemagne] ; Regina Santella [États-Unis] ; Elinor J. Sawyer [Royaume-Uni] ; Rita K. Schmutzler [Allemagne] ; Caroline Seynaeve [Pays-Bas] ; Mitul Shah [Royaume-Uni] ; Martha J. Shrubsole [États-Unis] ; Melissa C. Southey [Australie] ; Anthony J. Swerdlow [Royaume-Uni] ; Amanda E. Toland [États-Unis] ; Ian Tomlinson [Royaume-Uni] ; Diana Torres [Allemagne] ; Thérèse Truong [France] ; Giske Ursin [Norvège] ; Rob B. Van Der Luijt [Pays-Bas] ; Senno Verhoef [Pays-Bas] ; Alice S. Whittemore [États-Unis] ; Robert Winqvist [Finlande] ; Hui Zhao [Belgique] ; Shilin Zhao [États-Unis] ; Per Hall [Suède] ; Jacques Simard [Canada] ; Peter Kraft [États-Unis] ; Paul Pharoah [Royaume-Uni] ; David Hunter [États-Unis] ; Douglas F. Easton [Royaume-Uni] ; Wei Zheng [États-Unis]

Source :

PLoS Medicine [ 1549-1277 ] ; 2016.

RBID : PMC:4995025

Abstract

Background

Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.

Methods

We applied Mendelian randomization to evaluate the association between BMI and risk of breast cancer occurrence using data from two large breast cancer consortia. We created a weighted BMI genetic score comprising 84 BMI-associated genetic variants to predicted BMI. We evaluated genetically predicted BMI in association with breast cancer risk using individual-level data from the Breast Cancer Association Consortium (BCAC) (cases = 46,325, controls = 42,482). We further evaluated the association between genetically predicted BMI and breast cancer risk using summary statistics from 16,003 cases and 41,335 controls from the Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Project. Because most studies measured BMI after cancer diagnosis, we could not conduct a parallel analysis to adequately evaluate the association of measured BMI with breast cancer risk prospectively.

Results

In the BCAC data, genetically predicted BMI was found to be inversely associated with breast cancer risk (odds ratio [OR] = 0.65 per 5 kg/m² increase, 95% confidence interval [CI]: 0.56–0.75, p = 3.32 × 10⁻¹⁰). The associations were similar for both premenopausal (OR = 0.44, 95% CI:0.31–0.62, p = 9.91 × 10⁻⁸) and postmenopausal breast cancer (OR = 0.57, 95% CI: 0.46–0.71, p = 1.88 × 10⁻⁸). This association was replicated in the data from the DRIVE consortium (OR = 0.72, 95% CI: 0.60–0.84, p = 1.64 × 10⁻⁷). Single marker analyses identified 17 of the 84 BMI-associated single nucleotide polymorphisms (SNPs) in association with breast cancer risk at p < 0.05; for 16 of them, the allele associated with elevated BMI was associated with reduced breast cancer risk.

Conclusions

BMI predicted by genome-wide association studies (GWAS)-identified variants is inversely associated with the risk of both pre- and postmenopausal breast cancer. The reduced risk of postmenopausal breast cancer associated with genetically predicted BMI observed in this study differs from the positive association reported from studies using measured adult BMI. Understanding the reasons for this discrepancy may reveal insights into the complex relationship of genetic determinants of body weight in the etiology of breast cancer.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995025

DOI: 10.1371/journal.pmed.1002105
PubMed: 27551723
PubMed Central: 4995025

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Le document en format XML

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<author><name sortKey="Guo, Yan" sort="Guo, Yan" uniqKey="Guo Y" first="Yan" last="Guo">Yan Guo</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
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<author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
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<author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
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<author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
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<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
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<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
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<wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
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<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
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<author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name>
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<wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea>
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<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Ulm, Ulm</wicri:regionArea>
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<author><name sortKey="Dunning, Allison" sort="Dunning, Allison" uniqKey="Dunning A" first="Allison" last="Dunning">Allison Dunning</name>
<affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea>
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<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
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<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff014"><addr-line>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
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</author>
<author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name>
<affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Studies, The University of Chicago, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation wicri:level="1"><nlm:aff id="aff016"><addr-line>Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="aff017"><addr-line>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff018"><addr-line>Department of Molecular Genetics, University of Toronto, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation wicri:level="1"><nlm:aff id="aff019"><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California Irvine, Irvine, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation wicri:level="1"><nlm:aff id="aff020"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Studies, The University of Chicago, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="1"><nlm:aff id="aff021"><addr-line>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff022"><addr-line>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras, Valencia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name>
<affiliation wicri:level="1"><nlm:aff id="aff023"><addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name>
<affiliation wicri:level="1"><nlm:aff id="aff024"><addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff026"><addr-line>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brand, Judith" sort="Brand, Judith" uniqKey="Brand J" first="Judith" last="Brand">Judith Brand</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="1"><nlm:aff id="aff028"><addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff029"><addr-line>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff030"><addr-line>University of Tübingen, Tübingen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation wicri:level="1"><nlm:aff id="aff020"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff028"><addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff031"><addr-line>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
<affiliation wicri:level="1"><nlm:aff id="aff032"><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation wicri:level="1"><nlm:aff id="aff033"><addr-line>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff034"><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name>
<affiliation wicri:level="1"><nlm:aff id="aff035"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="aff036"><addr-line>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation wicri:level="1"><nlm:aff id="aff037"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation wicri:level="1"><nlm:aff id="aff038"><addr-line>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="1"><nlm:aff id="aff039"><addr-line>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
<affiliation wicri:level="1"><nlm:aff id="aff040"><addr-line>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Gynaecology Research Unit, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name>
<affiliation wicri:level="1"><nlm:aff id="aff041"><addr-line>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<affiliation wicri:level="1"><nlm:aff id="aff042"><addr-line>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff043"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation wicri:level="1"><nlm:aff id="aff044"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation wicri:level="1"><nlm:aff id="aff045"><addr-line>Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff046"><addr-line>Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation wicri:level="1"><nlm:aff id="aff047"><addr-line>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name>
<affiliation wicri:level="1"><nlm:aff id="aff048"><addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</addr-line>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gammon, Marilie" sort="Gammon, Marilie" uniqKey="Gammon M" first="Marilie" last="Gammon">Marilie Gammon</name>
<affiliation wicri:level="1"><nlm:aff id="aff049"><addr-line>Departments of Epidemiology, University of North Carolina Chapel-Hill, Chapel Hill, North Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Epidemiology, University of North Carolina Chapel-Hill, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<affiliation wicri:level="1"><nlm:aff id="aff050"><addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff051"><addr-line>University Paris-Sud, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1"><nlm:aff id="aff035"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1"><nlm:aff id="aff052"><addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation wicri:level="1"><nlm:aff id="aff053"><addr-line>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff054"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jasmine, Farzana" sort="Jasmine, Farzana" uniqKey="Jasmine F" first="Farzana" last="Jasmine">Farzana Jasmine</name>
<affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Studies, The University of Chicago, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<affiliation wicri:level="1"><nlm:aff id="aff055"><addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff056"><addr-line>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jones, Michael E" sort="Jones, Michael E" uniqKey="Jones M" first="Michael E." last="Jones">Michael E. Jones</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name>
<affiliation wicri:level="1"><nlm:aff id="aff052"><addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kibriya, Muhammad" sort="Kibriya, Muhammad" uniqKey="Kibriya M" first="Muhammad" last="Kibriya">Muhammad Kibriya</name>
<affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Studies, The University of Chicago, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name>
<affiliation wicri:level="1"><nlm:aff id="aff057"><addr-line>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff058"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koppert, Linetta B" sort="Koppert, Linetta B" uniqKey="Koppert L" first="Linetta B." last="Koppert">Linetta B. Koppert</name>
<affiliation wicri:level="1"><nlm:aff id="aff053"><addr-line>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation wicri:level="1"><nlm:aff id="aff059"><addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff060"><addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff061"><addr-line>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff026"><addr-line>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff062"><addr-line>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="1"><nlm:aff id="aff063"><addr-line>University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff035"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation wicri:level="1"><nlm:aff id="aff064"><addr-line>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name>
<affiliation wicri:level="1"><nlm:aff id="aff065"><addr-line>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="aff054"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Malone, Kathi E" sort="Malone, Kathi E" uniqKey="Malone K" first="Kathi E." last="Malone">Kathi E. Malone</name>
<affiliation wicri:level="1"><nlm:aff id="aff066"><addr-line>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation wicri:level="1"><nlm:aff id="aff059"><addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff060"><addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff061"><addr-line>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation wicri:level="1"><nlm:aff id="aff067"><addr-line>Department of Oncology – Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology – Pathology, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<affiliation wicri:level="1"><nlm:aff id="aff068"><addr-line>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff069"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name>
<affiliation wicri:level="1"><nlm:aff id="aff070"><addr-line>Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Anatomical Pathology, The Alfred Hospital, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name>
<affiliation wicri:level="1"><nlm:aff id="aff071"><addr-line>Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, VU University Medical Center, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="1"><nlm:aff id="aff072"><addr-line>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Gynaecology and Obstetrics, Technische Universität München, Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation wicri:level="1"><nlm:aff id="aff073"><addr-line>Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Beckman Research Institute of City of Hope, Duarte, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:aff id="aff074"><addr-line>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name>
<affiliation wicri:level="1"><nlm:aff id="aff075"><addr-line>Department of Oncology, University Hospital Gasthuisberg, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Oncology, University Hospital Gasthuisberg, Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<affiliation wicri:level="1"><nlm:aff id="aff076"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perez, Jose I A" sort="Perez, Jose I A" uniqKey="Perez J" first="Jose I. A." last="Perez">Jose I. A. Perez</name>
<affiliation wicri:level="1"><nlm:aff id="aff077"><addr-line>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perkins, Barbara" sort="Perkins, Barbara" uniqKey="Perkins B" first="Barbara" last="Perkins">Barbara Perkins</name>
<affiliation wicri:level="1"><nlm:aff id="aff078"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation wicri:level="1"><nlm:aff id="aff079"><addr-line>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name>
<affiliation wicri:level="1"><nlm:aff id="aff080"><addr-line>Peter MacCallum Cancer Center, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Peter MacCallum Cancer Center, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff081"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff082"><addr-line>Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name>
<affiliation wicri:level="1"><nlm:aff id="aff083"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Santella, Regina" sort="Santella, Regina" uniqKey="Santella R" first="Regina" last="Santella">Regina Santella</name>
<affiliation wicri:level="1"><nlm:aff id="aff084"><addr-line>Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff085"><addr-line>Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name>
<affiliation wicri:level="1"><nlm:aff id="aff086"><addr-line>Research Oncology, Guy’s Hospital, King's College London, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Oncology, Guy’s Hospital, King's College London, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="aff087"><addr-line>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff088"><addr-line>Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Integrated Oncology, University Hospital of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff089"><addr-line>Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine, University Hospital of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff090"><addr-line>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
<affiliation wicri:level="1"><nlm:aff id="aff053"><addr-line>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name>
<affiliation wicri:level="1"><nlm:aff id="aff078"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shrubsole, Martha J" sort="Shrubsole, Martha J" uniqKey="Shrubsole M" first="Martha J." last="Shrubsole">Martha J. Shrubsole</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="1"><nlm:aff id="aff091"><addr-line>Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J." last="Swerdlow">Anthony J. Swerdlow</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff092"><addr-line>Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name>
<affiliation wicri:level="1"><nlm:aff id="aff093"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<affiliation wicri:level="1"><nlm:aff id="aff094"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
<affiliation wicri:level="1"><nlm:aff id="aff052"><addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<affiliation wicri:level="1"><nlm:aff id="aff050"><addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff051"><addr-line>University Paris-Sud, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name>
<affiliation wicri:level="1"><nlm:aff id="aff095"><addr-line>Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name>
<affiliation wicri:level="1"><nlm:aff id="aff096"><addr-line>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name>
<affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name>
<affiliation wicri:level="1"><nlm:aff id="aff056"><addr-line>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<affiliation wicri:level="1"><nlm:aff id="aff083"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff097"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="aff098"><addr-line>Vesalius Research Center, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Vesalius Research Center, Leuven</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff099"><addr-line>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Shilin" sort="Zhao, Shilin" uniqKey="Zhao S" first="Shilin" last="Zhao">Shilin Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation wicri:level="1"><nlm:aff id="aff041"><addr-line>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff101"><addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff078"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name>
<affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff101"><addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff078"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent</title>
<author><name sortKey="Guo, Yan" sort="Guo, Yan" uniqKey="Guo Y" first="Yan" last="Guo">Yan Guo</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Warren Andersen, Shaneda" sort="Warren Andersen, Shaneda" uniqKey="Warren Andersen S" first="Shaneda" last="Warren Andersen">Shaneda Warren Andersen</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Ulm, Ulm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dunning, Allison" sort="Dunning, Allison" uniqKey="Dunning A" first="Allison" last="Dunning">Allison Dunning</name>
<affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<affiliation wicri:level="1"><nlm:aff id="aff012"><addr-line>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff014"><addr-line>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name>
<affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Studies, The University of Chicago, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation wicri:level="1"><nlm:aff id="aff016"><addr-line>Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="aff017"><addr-line>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff018"><addr-line>Department of Molecular Genetics, University of Toronto, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation wicri:level="1"><nlm:aff id="aff019"><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California Irvine, Irvine, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation wicri:level="1"><nlm:aff id="aff020"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Studies, The University of Chicago, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="1"><nlm:aff id="aff021"><addr-line>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff022"><addr-line>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras, Valencia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name>
<affiliation wicri:level="1"><nlm:aff id="aff023"><addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name>
<affiliation wicri:level="1"><nlm:aff id="aff024"><addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff026"><addr-line>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brand, Judith" sort="Brand, Judith" uniqKey="Brand J" first="Judith" last="Brand">Judith Brand</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="1"><nlm:aff id="aff028"><addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff029"><addr-line>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff030"><addr-line>University of Tübingen, Tübingen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation wicri:level="1"><nlm:aff id="aff020"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff028"><addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff031"><addr-line>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
<affiliation wicri:level="1"><nlm:aff id="aff032"><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation wicri:level="1"><nlm:aff id="aff033"><addr-line>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff034"><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name>
<affiliation wicri:level="1"><nlm:aff id="aff035"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="aff036"><addr-line>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation wicri:level="1"><nlm:aff id="aff037"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation wicri:level="1"><nlm:aff id="aff038"><addr-line>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="1"><nlm:aff id="aff039"><addr-line>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
<affiliation wicri:level="1"><nlm:aff id="aff040"><addr-line>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Gynaecology Research Unit, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name>
<affiliation wicri:level="1"><nlm:aff id="aff041"><addr-line>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<affiliation wicri:level="1"><nlm:aff id="aff042"><addr-line>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff043"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation wicri:level="1"><nlm:aff id="aff044"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation wicri:level="1"><nlm:aff id="aff045"><addr-line>Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff046"><addr-line>Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation wicri:level="1"><nlm:aff id="aff047"><addr-line>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name>
<affiliation wicri:level="1"><nlm:aff id="aff048"><addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</addr-line>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gammon, Marilie" sort="Gammon, Marilie" uniqKey="Gammon M" first="Marilie" last="Gammon">Marilie Gammon</name>
<affiliation wicri:level="1"><nlm:aff id="aff049"><addr-line>Departments of Epidemiology, University of North Carolina Chapel-Hill, Chapel Hill, North Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Epidemiology, University of North Carolina Chapel-Hill, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<affiliation wicri:level="1"><nlm:aff id="aff050"><addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff051"><addr-line>University Paris-Sud, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1"><nlm:aff id="aff035"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1"><nlm:aff id="aff052"><addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation wicri:level="1"><nlm:aff id="aff053"><addr-line>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff054"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jasmine, Farzana" sort="Jasmine, Farzana" uniqKey="Jasmine F" first="Farzana" last="Jasmine">Farzana Jasmine</name>
<affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Studies, The University of Chicago, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<affiliation wicri:level="1"><nlm:aff id="aff055"><addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff056"><addr-line>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jones, Michael E" sort="Jones, Michael E" uniqKey="Jones M" first="Michael E." last="Jones">Michael E. Jones</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name>
<affiliation wicri:level="1"><nlm:aff id="aff052"><addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kibriya, Muhammad" sort="Kibriya, Muhammad" uniqKey="Kibriya M" first="Muhammad" last="Kibriya">Muhammad Kibriya</name>
<affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Studies, The University of Chicago, Chicago, Illinois</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name>
<affiliation wicri:level="1"><nlm:aff id="aff057"><addr-line>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff058"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koppert, Linetta B" sort="Koppert, Linetta B" uniqKey="Koppert L" first="Linetta B." last="Koppert">Linetta B. Koppert</name>
<affiliation wicri:level="1"><nlm:aff id="aff053"><addr-line>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation wicri:level="1"><nlm:aff id="aff059"><addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff060"><addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff061"><addr-line>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff026"><addr-line>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff062"><addr-line>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="1"><nlm:aff id="aff063"><addr-line>University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff035"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation wicri:level="1"><nlm:aff id="aff064"><addr-line>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name>
<affiliation wicri:level="1"><nlm:aff id="aff065"><addr-line>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="aff054"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Malone, Kathi E" sort="Malone, Kathi E" uniqKey="Malone K" first="Kathi E." last="Malone">Kathi E. Malone</name>
<affiliation wicri:level="1"><nlm:aff id="aff066"><addr-line>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation wicri:level="1"><nlm:aff id="aff059"><addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff060"><addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff061"><addr-line>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation wicri:level="1"><nlm:aff id="aff067"><addr-line>Department of Oncology – Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology – Pathology, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<affiliation wicri:level="1"><nlm:aff id="aff068"><addr-line>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff069"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name>
<affiliation wicri:level="1"><nlm:aff id="aff070"><addr-line>Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Anatomical Pathology, The Alfred Hospital, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name>
<affiliation wicri:level="1"><nlm:aff id="aff071"><addr-line>Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, VU University Medical Center, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="1"><nlm:aff id="aff072"><addr-line>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Gynaecology and Obstetrics, Technische Universität München, Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation wicri:level="1"><nlm:aff id="aff073"><addr-line>Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Beckman Research Institute of City of Hope, Duarte, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:aff id="aff074"><addr-line>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name>
<affiliation wicri:level="1"><nlm:aff id="aff075"><addr-line>Department of Oncology, University Hospital Gasthuisberg, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Oncology, University Hospital Gasthuisberg, Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<affiliation wicri:level="1"><nlm:aff id="aff076"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perez, Jose I A" sort="Perez, Jose I A" uniqKey="Perez J" first="Jose I. A." last="Perez">Jose I. A. Perez</name>
<affiliation wicri:level="1"><nlm:aff id="aff077"><addr-line>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perkins, Barbara" sort="Perkins, Barbara" uniqKey="Perkins B" first="Barbara" last="Perkins">Barbara Perkins</name>
<affiliation wicri:level="1"><nlm:aff id="aff078"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation wicri:level="1"><nlm:aff id="aff079"><addr-line>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name>
<affiliation wicri:level="1"><nlm:aff id="aff080"><addr-line>Peter MacCallum Cancer Center, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Peter MacCallum Cancer Center, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff081"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff082"><addr-line>Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name>
<affiliation wicri:level="1"><nlm:aff id="aff083"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Santella, Regina" sort="Santella, Regina" uniqKey="Santella R" first="Regina" last="Santella">Regina Santella</name>
<affiliation wicri:level="1"><nlm:aff id="aff084"><addr-line>Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff085"><addr-line>Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name>
<affiliation wicri:level="1"><nlm:aff id="aff086"><addr-line>Research Oncology, Guy’s Hospital, King's College London, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Oncology, Guy’s Hospital, King's College London, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="aff087"><addr-line>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff088"><addr-line>Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Integrated Oncology, University Hospital of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff089"><addr-line>Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine, University Hospital of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff090"><addr-line>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
<affiliation wicri:level="1"><nlm:aff id="aff053"><addr-line>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name>
<affiliation wicri:level="1"><nlm:aff id="aff078"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shrubsole, Martha J" sort="Shrubsole, Martha J" uniqKey="Shrubsole M" first="Martha J." last="Shrubsole">Martha J. Shrubsole</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="1"><nlm:aff id="aff091"><addr-line>Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, The University of Melbourne, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J." last="Swerdlow">Anthony J. Swerdlow</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff092"><addr-line>Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name>
<affiliation wicri:level="1"><nlm:aff id="aff093"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<affiliation wicri:level="1"><nlm:aff id="aff094"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
<affiliation wicri:level="1"><nlm:aff id="aff052"><addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<affiliation wicri:level="1"><nlm:aff id="aff050"><addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff051"><addr-line>University Paris-Sud, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name>
<affiliation wicri:level="1"><nlm:aff id="aff095"><addr-line>Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name>
<affiliation wicri:level="1"><nlm:aff id="aff096"><addr-line>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name>
<affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name>
<affiliation wicri:level="1"><nlm:aff id="aff056"><addr-line>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<affiliation wicri:level="1"><nlm:aff id="aff083"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff097"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="aff098"><addr-line>Vesalius Research Center, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Vesalius Research Center, Leuven</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff099"><addr-line>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Shilin" sort="Zhao, Shilin" uniqKey="Zhao S" first="Shilin" last="Zhao">Shilin Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation wicri:level="1"><nlm:aff id="aff041"><addr-line>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff101"><addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff078"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name>
<affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff101"><addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff078"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS Medicine</title>
<idno type="ISSN">1549-1277</idno>
<idno type="eISSN">1549-1676</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title>
<p>Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>We applied Mendelian randomization to evaluate the association between BMI and risk of breast cancer occurrence using data from two large breast cancer consortia. We created a weighted BMI genetic score comprising 84 BMI-associated genetic variants to predicted BMI. We evaluated genetically predicted BMI in association with breast cancer risk using individual-level data from the Breast Cancer Association Consortium (BCAC) (cases  =  46,325, controls  =  42,482). We further evaluated the association between genetically predicted BMI and breast cancer risk using summary statistics from 16,003 cases and 41,335 controls from the Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Project. Because most studies measured BMI after cancer diagnosis, we could not conduct a parallel analysis to adequately evaluate the association of measured BMI with breast cancer risk prospectively.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>In the BCAC data, genetically predicted BMI was found to be inversely associated with breast cancer risk (odds ratio [OR]  =  0.65 per 5 kg/m<sup>2</sup>
 increase, 95% confidence interval [CI]: 0.56–0.75, <italic>p</italic>
 = 3.32 × 10<sup>−10</sup>
). The associations were similar for both premenopausal (OR   =   0.44, 95% CI:0.31–0.62, <italic>p</italic>
  =  9.91 × 10<sup>−8</sup>
) and postmenopausal breast cancer (OR  =  0.57, 95% CI: 0.46–0.71, <italic>p</italic>
  =  1.88 × 10<sup>−8</sup>
). This association was replicated in the data from the DRIVE consortium (OR  =  0.72, 95% CI: 0.60–0.84, <italic>p</italic>
   =   1.64 × 10<sup>−7</sup>
). Single marker analyses identified 17 of the 84 BMI-associated single nucleotide polymorphisms (SNPs) in association with breast cancer risk at <italic>p</italic>
 < 0.05; for 16 of them, the allele associated with elevated BMI was associated with reduced breast cancer risk.</p>
</sec>
<sec id="sec004"><title>Conclusions</title>
<p>BMI predicted by genome-wide association studies (GWAS)-identified variants is inversely associated with the risk of both pre- and postmenopausal breast cancer. The reduced risk of postmenopausal breast cancer associated with genetically predicted BMI observed in this study differs from the positive association reported from studies using measured adult BMI. Understanding the reasons for this discrepancy may reveal insights into the complex relationship of genetic determinants of body weight in the etiology of breast cancer.</p>
</sec>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Med</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS Med</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosmed</journal-id>
<journal-title-group><journal-title>PLoS Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">1549-1277</issn>
<issn pub-type="epub">1549-1676</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27551723</article-id>
<article-id pub-id-type="pmc">4995025</article-id>
<article-id pub-id-type="doi">10.1371/journal.pmed.1002105</article-id>
<article-id pub-id-type="publisher-id">PMEDICINE-D-15-03646</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancers and Neoplasms</subject>
<subj-group><subject>Breast Tumors</subject>
<subj-group><subject>Breast Cancer</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Genetics</subject>
<subj-group><subject>Human Genetics</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Physiology</subject>
<subj-group><subject>Physiological Parameters</subject>
<subj-group><subject>Body Weight</subject>
<subj-group><subject>Body Mass Index</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Physiology</subject>
<subj-group><subject>Physiological Parameters</subject>
<subj-group><subject>Body Weight</subject>
<subj-group><subject>Body Mass Index</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancer Risk Factors</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Social Sciences</subject>
<subj-group><subject>Sociology</subject>
<subj-group><subject>Consortia</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Computational Biology</subject>
<subj-group><subject>Genome Analysis</subject>
<subj-group><subject>Genome-Wide Association Studies</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Genetics</subject>
<subj-group><subject>Genomics</subject>
<subj-group><subject>Genome Analysis</subject>
<subj-group><subject>Genome-Wide Association Studies</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Genetics</subject>
<subj-group><subject>Human Genetics</subject>
<subj-group><subject>Genome-Wide Association Studies</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Epidemiology</subject>
<subj-group><subject>Genetic Epidemiology</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Endocrinology</subject>
<subj-group><subject>Endocrine Physiology</subject>
<subj-group><subject>Menstrual Cycle</subject>
<subj-group><subject>Menarche</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Physiology</subject>
<subj-group><subject>Endocrine Physiology</subject>
<subj-group><subject>Menstrual Cycle</subject>
<subj-group><subject>Menarche</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Physiology</subject>
<subj-group><subject>Endocrine Physiology</subject>
<subj-group><subject>Menstrual Cycle</subject>
<subj-group><subject>Menarche</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Physiology</subject>
<subj-group><subject>Reproductive Physiology</subject>
<subj-group><subject>Menstrual Cycle</subject>
<subj-group><subject>Menarche</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Physiology</subject>
<subj-group><subject>Reproductive Physiology</subject>
<subj-group><subject>Menstrual Cycle</subject>
<subj-group><subject>Menarche</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent</article-title>
<alt-title alt-title-type="running-head">BMI and Breast Cancer Risk: Mendelian Randomization Analyses of Data from Women of European Descent</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Guo</surname>
<given-names>Yan</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Warren Andersen</surname>
<given-names>Shaneda</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shu</surname>
<given-names>Xiao-Ou</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Michailidou</surname>
<given-names>Kyriaki</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bolla</surname>
<given-names>Manjeet K.</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Qin</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Garcia-Closas</surname>
<given-names>Montserrat</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Milne</surname>
<given-names>Roger L.</given-names>
</name>
<xref ref-type="aff" rid="aff006"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Marjanka K.</given-names>
</name>
<xref ref-type="aff" rid="aff008"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chang-Claude</surname>
<given-names>Jenny</given-names>
</name>
<xref ref-type="aff" rid="aff009"><sup>9</sup>
</xref>
<xref ref-type="aff" rid="aff010"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dunning</surname>
<given-names>Allison</given-names>
</name>
<xref ref-type="aff" rid="aff011"><sup>11</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bojesen</surname>
<given-names>Stig E.</given-names>
</name>
<xref ref-type="aff" rid="aff012"><sup>12</sup>
</xref>
<xref ref-type="aff" rid="aff013"><sup>13</sup>
</xref>
<xref ref-type="aff" rid="aff014"><sup>14</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ahsan</surname>
<given-names>Habibul</given-names>
</name>
<xref ref-type="aff" rid="aff015"><sup>15</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aittomäki</surname>
<given-names>Kristiina</given-names>
</name>
<xref ref-type="aff" rid="aff016"><sup>16</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andrulis</surname>
<given-names>Irene L.</given-names>
</name>
<xref ref-type="aff" rid="aff017"><sup>17</sup>
</xref>
<xref ref-type="aff" rid="aff018"><sup>18</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Anton-Culver</surname>
<given-names>Hoda</given-names>
</name>
<xref ref-type="aff" rid="aff019"><sup>19</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0001-9320-8684</contrib-id>
<name><surname>Arndt</surname>
<given-names>Volker</given-names>
</name>
<xref ref-type="aff" rid="aff020"><sup>20</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beckmann</surname>
<given-names>Matthias W.</given-names>
</name>
<xref ref-type="aff" rid="aff015"><sup>15</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beeghly-Fadiel</surname>
<given-names>Alicia</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benitez</surname>
<given-names>Javier</given-names>
</name>
<xref ref-type="aff" rid="aff021"><sup>21</sup>
</xref>
<xref ref-type="aff" rid="aff022"><sup>22</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bogdanova</surname>
<given-names>Natalia V.</given-names>
</name>
<xref ref-type="aff" rid="aff023"><sup>23</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bonanni</surname>
<given-names>Bernardo</given-names>
</name>
<xref ref-type="aff" rid="aff024"><sup>24</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Børresen-Dale</surname>
<given-names>Anne-Lise</given-names>
</name>
<xref ref-type="aff" rid="aff025"><sup>25</sup>
</xref>
<xref ref-type="aff" rid="aff026"><sup>26</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brand</surname>
<given-names>Judith</given-names>
</name>
<xref ref-type="aff" rid="aff027"><sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brauch</surname>
<given-names>Hiltrud</given-names>
</name>
<xref ref-type="aff" rid="aff028"><sup>28</sup>
</xref>
<xref ref-type="aff" rid="aff029"><sup>29</sup>
</xref>
<xref ref-type="aff" rid="aff030"><sup>30</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brenner</surname>
<given-names>Hermann</given-names>
</name>
<xref ref-type="aff" rid="aff020"><sup>20</sup>
</xref>
<xref ref-type="aff" rid="aff028"><sup>28</sup>
</xref>
<xref ref-type="aff" rid="aff031"><sup>31</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brüning</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="aff032"><sup>32</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burwinkel</surname>
<given-names>Barbara</given-names>
</name>
<xref ref-type="aff" rid="aff033"><sup>33</sup>
</xref>
<xref ref-type="aff" rid="aff034"><sup>34</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casey</surname>
<given-names>Graham</given-names>
</name>
<xref ref-type="aff" rid="aff035"><sup>35</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<xref ref-type="aff" rid="aff036"><sup>36</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Couch</surname>
<given-names>Fergus J.</given-names>
</name>
<xref ref-type="aff" rid="aff037"><sup>37</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-5138-1099</contrib-id>
<name><surname>Cox</surname>
<given-names>Angela</given-names>
</name>
<xref ref-type="aff" rid="aff038"><sup>38</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cross</surname>
<given-names>Simon S.</given-names>
</name>
<xref ref-type="aff" rid="aff011"><sup>11</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Czene</surname>
<given-names>Kamila</given-names>
</name>
<xref ref-type="aff" rid="aff027"><sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-8023-2009</contrib-id>
<name><surname>Devilee</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff039"><sup>39</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dörk</surname>
<given-names>Thilo</given-names>
</name>
<xref ref-type="aff" rid="aff040"><sup>40</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dumont</surname>
<given-names>Martine</given-names>
</name>
<xref ref-type="aff" rid="aff041"><sup>41</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fasching</surname>
<given-names>Peter A.</given-names>
</name>
<xref ref-type="aff" rid="aff042"><sup>42</sup>
</xref>
<xref ref-type="aff" rid="aff043"><sup>43</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Figueroa</surname>
<given-names>Jonine</given-names>
</name>
<xref ref-type="aff" rid="aff044"><sup>44</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flesch-Janys</surname>
<given-names>Dieter</given-names>
</name>
<xref ref-type="aff" rid="aff045"><sup>45</sup>
</xref>
<xref ref-type="aff" rid="aff046"><sup>46</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fletcher</surname>
<given-names>Olivia</given-names>
</name>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flyger</surname>
<given-names>Henrik</given-names>
</name>
<xref ref-type="aff" rid="aff047"><sup>47</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fostira</surname>
<given-names>Florentia</given-names>
</name>
<xref ref-type="aff" rid="aff048"><sup>48</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gammon</surname>
<given-names>Marilie</given-names>
</name>
<xref ref-type="aff" rid="aff049"><sup>49</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giles</surname>
<given-names>Graham G.</given-names>
</name>
<xref ref-type="aff" rid="aff006"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guénel</surname>
<given-names>Pascal</given-names>
</name>
<xref ref-type="aff" rid="aff050"><sup>50</sup>
</xref>
<xref ref-type="aff" rid="aff051"><sup>51</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haiman</surname>
<given-names>Christopher A.</given-names>
</name>
<xref ref-type="aff" rid="aff035"><sup>35</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamann</surname>
<given-names>Ute</given-names>
</name>
<xref ref-type="aff" rid="aff052"><sup>52</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hooning</surname>
<given-names>Maartje J.</given-names>
</name>
<xref ref-type="aff" rid="aff053"><sup>53</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hopper</surname>
<given-names>John L.</given-names>
</name>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jakubowska</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="aff054"><sup>54</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jasmine</surname>
<given-names>Farzana</given-names>
</name>
<xref ref-type="aff" rid="aff015"><sup>15</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jenkins</surname>
<given-names>Mark</given-names>
</name>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>John</surname>
<given-names>Esther M.</given-names>
</name>
<xref ref-type="aff" rid="aff055"><sup>55</sup>
</xref>
<xref ref-type="aff" rid="aff056"><sup>56</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Johnson</surname>
<given-names>Nichola</given-names>
</name>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Michael E.</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kabisch</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="aff052"><sup>52</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0001-9784-6958</contrib-id>
<name><surname>Kibriya</surname>
<given-names>Muhammad</given-names>
</name>
<xref ref-type="aff" rid="aff015"><sup>15</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Knight</surname>
<given-names>Julia A.</given-names>
</name>
<xref ref-type="aff" rid="aff057"><sup>57</sup>
</xref>
<xref ref-type="aff" rid="aff058"><sup>58</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koppert</surname>
<given-names>Linetta B.</given-names>
</name>
<xref ref-type="aff" rid="aff053"><sup>53</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kosma</surname>
<given-names>Veli-Matti</given-names>
</name>
<xref ref-type="aff" rid="aff059"><sup>59</sup>
</xref>
<xref ref-type="aff" rid="aff060"><sup>60</sup>
</xref>
<xref ref-type="aff" rid="aff061"><sup>61</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kristensen</surname>
<given-names>Vessela</given-names>
</name>
<xref ref-type="aff" rid="aff025"><sup>25</sup>
</xref>
<xref ref-type="aff" rid="aff026"><sup>26</sup>
</xref>
<xref ref-type="aff" rid="aff062"><sup>62</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Le Marchand</surname>
<given-names>Loic</given-names>
</name>
<xref ref-type="aff" rid="aff063"><sup>63</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Eunjung</given-names>
</name>
<xref ref-type="aff" rid="aff035"><sup>35</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Jingmei</given-names>
</name>
<xref ref-type="aff" rid="aff027"><sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lindblom</surname>
<given-names>Annika</given-names>
</name>
<xref ref-type="aff" rid="aff064"><sup>64</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-5088-6343</contrib-id>
<name><surname>Luben</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="aff065"><sup>65</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lubinski</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="aff054"><sup>54</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Malone</surname>
<given-names>Kathi E.</given-names>
</name>
<xref ref-type="aff" rid="aff066"><sup>66</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mannermaa</surname>
<given-names>Arto</given-names>
</name>
<xref ref-type="aff" rid="aff059"><sup>59</sup>
</xref>
<xref ref-type="aff" rid="aff060"><sup>60</sup>
</xref>
<xref ref-type="aff" rid="aff061"><sup>61</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Margolin</surname>
<given-names>Sara</given-names>
</name>
<xref ref-type="aff" rid="aff067"><sup>67</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-6591-3367</contrib-id>
<name><surname>Marme</surname>
<given-names>Frederik</given-names>
</name>
<xref ref-type="aff" rid="aff068"><sup>68</sup>
</xref>
<xref ref-type="aff" rid="aff069"><sup>69</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McLean</surname>
<given-names>Catriona</given-names>
</name>
<xref ref-type="aff" rid="aff070"><sup>70</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0003-1169-3853</contrib-id>
<name><surname>Meijers-Heijboer</surname>
<given-names>Hanne</given-names>
</name>
<xref ref-type="aff" rid="aff071"><sup>71</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meindl</surname>
<given-names>Alfons</given-names>
</name>
<xref ref-type="aff" rid="aff072"><sup>72</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neuhausen</surname>
<given-names>Susan L.</given-names>
</name>
<xref ref-type="aff" rid="aff073"><sup>73</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nevanlinna</surname>
<given-names>Heli</given-names>
</name>
<xref ref-type="aff" rid="aff074"><sup>74</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neven</surname>
<given-names>Patrick</given-names>
</name>
<xref ref-type="aff" rid="aff075"><sup>75</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olson</surname>
<given-names>Janet E.</given-names>
</name>
<xref ref-type="aff" rid="aff076"><sup>76</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Perez</surname>
<given-names>Jose I. A.</given-names>
</name>
<xref ref-type="aff" rid="aff077"><sup>77</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Perkins</surname>
<given-names>Barbara</given-names>
</name>
<xref ref-type="aff" rid="aff078"><sup>78</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0001-6951-6855</contrib-id>
<name><surname>Peterlongo</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="aff079"><sup>79</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Phillips</surname>
<given-names>Kelly-Anne</given-names>
</name>
<xref ref-type="aff" rid="aff080"><sup>80</sup>
</xref>
<xref ref-type="aff" rid="aff081"><sup>81</sup>
</xref>
<xref ref-type="aff" rid="aff082"><sup>82</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pylkäs</surname>
<given-names>Katri</given-names>
</name>
<xref ref-type="aff" rid="aff083"><sup>83</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rudolph</surname>
<given-names>Anja</given-names>
</name>
<xref ref-type="aff" rid="aff009"><sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Santella</surname>
<given-names>Regina</given-names>
</name>
<xref ref-type="aff" rid="aff084"><sup>84</sup>
</xref>
<xref ref-type="aff" rid="aff085"><sup>85</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sawyer</surname>
<given-names>Elinor J.</given-names>
</name>
<xref ref-type="aff" rid="aff086"><sup>86</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmutzler</surname>
<given-names>Rita K.</given-names>
</name>
<xref ref-type="aff" rid="aff087"><sup>87</sup>
</xref>
<xref ref-type="aff" rid="aff088"><sup>88</sup>
</xref>
<xref ref-type="aff" rid="aff089"><sup>89</sup>
</xref>
<xref ref-type="aff" rid="aff090"><sup>90</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seynaeve</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="aff053"><sup>53</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shah</surname>
<given-names>Mitul</given-names>
</name>
<xref ref-type="aff" rid="aff078"><sup>78</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shrubsole</surname>
<given-names>Martha J.</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Southey</surname>
<given-names>Melissa C.</given-names>
</name>
<xref ref-type="aff" rid="aff091"><sup>91</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Swerdlow</surname>
<given-names>Anthony J.</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff092"><sup>92</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Toland</surname>
<given-names>Amanda E.</given-names>
</name>
<xref ref-type="aff" rid="aff093"><sup>93</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tomlinson</surname>
<given-names>Ian</given-names>
</name>
<xref ref-type="aff" rid="aff094"><sup>94</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Torres</surname>
<given-names>Diana</given-names>
</name>
<xref ref-type="aff" rid="aff052"><sup>52</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Truong</surname>
<given-names>Thérèse</given-names>
</name>
<xref ref-type="aff" rid="aff050"><sup>50</sup>
</xref>
<xref ref-type="aff" rid="aff051"><sup>51</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ursin</surname>
<given-names>Giske</given-names>
</name>
<xref ref-type="aff" rid="aff095"><sup>95</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Van Der Luijt</surname>
<given-names>Rob B.</given-names>
</name>
<xref ref-type="aff" rid="aff096"><sup>96</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Verhoef</surname>
<given-names>Senno</given-names>
</name>
<xref ref-type="aff" rid="aff008"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Whittemore</surname>
<given-names>Alice S.</given-names>
</name>
<xref ref-type="aff" rid="aff056"><sup>56</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Winqvist</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="aff083"><sup>83</sup>
</xref>
<xref ref-type="aff" rid="aff097"><sup>97</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Hui</given-names>
</name>
<xref ref-type="aff" rid="aff098"><sup>98</sup>
</xref>
<xref ref-type="aff" rid="aff099"><sup>99</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Shilin</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hall</surname>
<given-names>Per</given-names>
</name>
<xref ref-type="aff" rid="aff027"><sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simard</surname>
<given-names>Jacques</given-names>
</name>
<xref ref-type="aff" rid="aff041"><sup>41</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kraft</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff100"><sup>100</sup>
</xref>
<xref ref-type="aff" rid="aff101"><sup>101</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8494-732X</contrib-id>
<name><surname>Pharoah</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff078"><sup>78</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hunter</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="aff100"><sup>100</sup>
</xref>
<xref ref-type="aff" rid="aff101"><sup>101</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Easton</surname>
<given-names>Douglas F.</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff078"><sup>78</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zheng</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</aff>
<aff id="aff004"><label>4</label>
<addr-line>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom</addr-line>
</aff>
<aff id="aff005"><label>5</label>
<addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line>
</aff>
<aff id="aff006"><label>6</label>
<addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line>
</aff>
<aff id="aff007"><label>7</label>
<addr-line>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</aff>
<aff id="aff008"><label>8</label>
<addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line>
</aff>
<aff id="aff009"><label>9</label>
<addr-line>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</aff>
<aff id="aff010"><label>10</label>
<addr-line>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line>
</aff>
<aff id="aff011"><label>11</label>
<addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line>
</aff>
<aff id="aff012"><label>12</label>
<addr-line>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line>
</aff>
<aff id="aff013"><label>13</label>
<addr-line>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</aff>
<aff id="aff014"><label>14</label>
<addr-line>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</aff>
<aff id="aff015"><label>15</label>
<addr-line>Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America</addr-line>
</aff>
<aff id="aff016"><label>16</label>
<addr-line>Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</addr-line>
</aff>
<aff id="aff017"><label>17</label>
<addr-line>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</aff>
<aff id="aff018"><label>18</label>
<addr-line>Department of Molecular Genetics, University of Toronto, Toronto, Canada</addr-line>
</aff>
<aff id="aff019"><label>19</label>
<addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line>
</aff>
<aff id="aff020"><label>20</label>
<addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</aff>
<aff id="aff021"><label>21</label>
<addr-line>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</addr-line>
</aff>
<aff id="aff022"><label>22</label>
<addr-line>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</addr-line>
</aff>
<aff id="aff023"><label>23</label>
<addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</aff>
<aff id="aff024"><label>24</label>
<addr-line>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</addr-line>
</aff>
<aff id="aff025"><label>25</label>
<addr-line>Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</addr-line>
</aff>
<aff id="aff026"><label>26</label>
<addr-line>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</aff>
<aff id="aff027"><label>27</label>
<addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</aff>
<aff id="aff028"><label>28</label>
<addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</aff>
<aff id="aff029"><label>29</label>
<addr-line>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</addr-line>
</aff>
<aff id="aff030"><label>30</label>
<addr-line>University of Tübingen, Tübingen, Germany</addr-line>
</aff>
<aff id="aff031"><label>31</label>
<addr-line>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</aff>
<aff id="aff032"><label>32</label>
<addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</addr-line>
</aff>
<aff id="aff033"><label>33</label>
<addr-line>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</aff>
<aff id="aff034"><label>34</label>
<addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</aff>
<aff id="aff035"><label>35</label>
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</aff>
<aff id="aff036"><label>36</label>
<addr-line>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</addr-line>
</aff>
<aff id="aff037"><label>37</label>
<addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</aff>
<aff id="aff038"><label>38</label>
<addr-line>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line>
</aff>
<aff id="aff039"><label>39</label>
<addr-line>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</aff>
<aff id="aff040"><label>40</label>
<addr-line>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</addr-line>
</aff>
<aff id="aff041"><label>41</label>
<addr-line>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</aff>
<aff id="aff042"><label>42</label>
<addr-line>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line>
</aff>
<aff id="aff043"><label>43</label>
<addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, United States of America</addr-line>
</aff>
<aff id="aff044"><label>44</label>
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line>
</aff>
<aff id="aff045"><label>45</label>
<addr-line>Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</aff>
<aff id="aff046"><label>46</label>
<addr-line>Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</aff>
<aff id="aff047"><label>47</label>
<addr-line>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</aff>
<aff id="aff048"><label>48</label>
<addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</addr-line>
</aff>
<aff id="aff049"><label>49</label>
<addr-line>Departments of Epidemiology, University of North Carolina Chapel-Hill, Chapel Hill, North Carolina, United States of America</addr-line>
</aff>
<aff id="aff050"><label>50</label>
<addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</aff>
<aff id="aff051"><label>51</label>
<addr-line>University Paris-Sud, Villejuif, France</addr-line>
</aff>
<aff id="aff052"><label>52</label>
<addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</aff>
<aff id="aff053"><label>53</label>
<addr-line>Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line>
</aff>
<aff id="aff054"><label>54</label>
<addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line>
</aff>
<aff id="aff055"><label>55</label>
<addr-line>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line>
</aff>
<aff id="aff056"><label>56</label>
<addr-line>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America</addr-line>
</aff>
<aff id="aff057"><label>57</label>
<addr-line>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</aff>
<aff id="aff058"><label>58</label>
<addr-line>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</addr-line>
</aff>
<aff id="aff059"><label>59</label>
<addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</aff>
<aff id="aff060"><label>60</label>
<addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</aff>
<aff id="aff061"><label>61</label>
<addr-line>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</addr-line>
</aff>
<aff id="aff062"><label>62</label>
<addr-line>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</addr-line>
</aff>
<aff id="aff063"><label>63</label>
<addr-line>University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America</addr-line>
</aff>
<aff id="aff064"><label>64</label>
<addr-line>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</addr-line>
</aff>
<aff id="aff065"><label>65</label>
<addr-line>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</aff>
<aff id="aff066"><label>66</label>
<addr-line>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America</addr-line>
</aff>
<aff id="aff067"><label>67</label>
<addr-line>Department of Oncology – Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line>
</aff>
<aff id="aff068"><label>68</label>
<addr-line>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</addr-line>
</aff>
<aff id="aff069"><label>69</label>
<addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line>
</aff>
<aff id="aff070"><label>70</label>
<addr-line>Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</addr-line>
</aff>
<aff id="aff071"><label>71</label>
<addr-line>Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands</addr-line>
</aff>
<aff id="aff072"><label>72</label>
<addr-line>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</addr-line>
</aff>
<aff id="aff073"><label>73</label>
<addr-line>Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line>
</aff>
<aff id="aff074"><label>74</label>
<addr-line>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</addr-line>
</aff>
<aff id="aff075"><label>75</label>
<addr-line>Department of Oncology, University Hospital Gasthuisberg, Leuven, Belgium</addr-line>
</aff>
<aff id="aff076"><label>76</label>
<addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</aff>
<aff id="aff077"><label>77</label>
<addr-line>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</addr-line>
</aff>
<aff id="aff078"><label>78</label>
<addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</aff>
<aff id="aff079"><label>79</label>
<addr-line>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</addr-line>
</aff>
<aff id="aff080"><label>80</label>
<addr-line>Peter MacCallum Cancer Center, The University of Melbourne, Melbourne, Australia</addr-line>
</aff>
<aff id="aff081"><label>81</label>
<addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia</addr-line>
</aff>
<aff id="aff082"><label>82</label>
<addr-line>Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy, Australia</addr-line>
</aff>
<aff id="aff083"><label>83</label>
<addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</addr-line>
</aff>
<aff id="aff084"><label>84</label>
<addr-line>Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, United States of America</addr-line>
</aff>
<aff id="aff085"><label>85</label>
<addr-line>Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York, United States of America</addr-line>
</aff>
<aff id="aff086"><label>86</label>
<addr-line>Research Oncology, Guy’s Hospital, King's College London, London, United Kingdom</addr-line>
</aff>
<aff id="aff087"><label>87</label>
<addr-line>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</addr-line>
</aff>
<aff id="aff088"><label>88</label>
<addr-line>Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</addr-line>
</aff>
<aff id="aff089"><label>89</label>
<addr-line>Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</addr-line>
</aff>
<aff id="aff090"><label>90</label>
<addr-line>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</addr-line>
</aff>
<aff id="aff091"><label>91</label>
<addr-line>Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line>
</aff>
<aff id="aff092"><label>92</label>
<addr-line>Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom</addr-line>
</aff>
<aff id="aff093"><label>93</label>
<addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America</addr-line>
</aff>
<aff id="aff094"><label>94</label>
<addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</addr-line>
</aff>
<aff id="aff095"><label>95</label>
<addr-line>Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway</addr-line>
</aff>
<aff id="aff096"><label>96</label>
<addr-line>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</addr-line>
</aff>
<aff id="aff097"><label>97</label>
<addr-line>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</addr-line>
</aff>
<aff id="aff098"><label>98</label>
<addr-line>Vesalius Research Center, Leuven, Belgium</addr-line>
</aff>
<aff id="aff099"><label>99</label>
<addr-line>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</addr-line>
</aff>
<aff id="aff100"><label>100</label>
<addr-line>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</aff>
<aff id="aff101"><label>101</label>
<addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Beck</surname>
<given-names>Andrew H.</given-names>
</name>
<role>Academic Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Harvard Medical School, UNITED STATES</addr-line>
</aff>
<author-notes><fn fn-type="COI-statement" id="coi001"><p>The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Analyzed the data: YG SWA WZ. Wrote the first draft of the manuscript: YG SWA WZ. Contributed to the writing of the manuscript: YG SWA WZ XOS. Agree with the manuscript’s results and conclusions: YG SWA XOS KM MKB QW MGC RLM MKS JCC AD SEB HA KA ILA HAC VA MWB ABF JBe NVB BBo ALBD JBr HBra HBre TB BBu GC GCT FJC AC SSC KC PD TD MD PAF JF DFJ OF HF FF MG GGG PG CAH UH MJH JLH AJ FJ MJ EMJ NJ MEJ MKa MKi JAK LBK VMK VK LLM EL JLi AL RL JLu KEM AMa SM FM CM HMH AMe SLN HN PN JEO JIAP BP PPe KAP KP AR RS EJS RKS CS MS MJS MCS AJS AET IT DT TT GU RBVDL SV ASW RW HZ SZ PH JS PK PPh DH DFE WZ. Contributed to the collection of data in the original consortia: XOS KM MKB QW MGC RLM MKS JCC AD SEB HA KA ILA HAC VA MWB ABF JBe NVB BBo ALBD JBr HBra HBre TB BBu GC GCT FJC AC SSC KC PD TD MD PAF JF DFJ OF HF FF MG GGG PG CAH UH MJH JLH AJ FJ MJ EMJ NJ MEJ MKa MKi JAK LBK VMK VK LLM EL JLi AL RL JLu KEM AMa SM FM CM HMH AMe SLN HN PN JEO JIAP BP PPe KAP KP AR RS EJS RKS CS MS MJS MCS AJS AET IT DT TT GU RBVDL SV ASW RW HZ SZ PH JS PK PPh DH DFE WZ. All authors have read, and confirm that they meet, ICMJE criteria for authorship.</p>
</fn>
<corresp id="cor001">* E-mail: <email>wei.zheng@vanderbilt.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>23</day>
<month>8</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><month>8</month>
<year>2016</year>
</pub-date>
<volume>13</volume>
<issue>8</issue>
<elocation-id>e1002105</elocation-id>
<history><date date-type="received"><day>3</day>
<month>12</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>24</day>
<month>6</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© 2016 Guo et al</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Guo et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="pmed.1002105.pdf"></self-uri>
<abstract><sec id="sec001"><title>Background</title>
<p>Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>We applied Mendelian randomization to evaluate the association between BMI and risk of breast cancer occurrence using data from two large breast cancer consortia. We created a weighted BMI genetic score comprising 84 BMI-associated genetic variants to predicted BMI. We evaluated genetically predicted BMI in association with breast cancer risk using individual-level data from the Breast Cancer Association Consortium (BCAC) (cases  =  46,325, controls  =  42,482). We further evaluated the association between genetically predicted BMI and breast cancer risk using summary statistics from 16,003 cases and 41,335 controls from the Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Project. Because most studies measured BMI after cancer diagnosis, we could not conduct a parallel analysis to adequately evaluate the association of measured BMI with breast cancer risk prospectively.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>In the BCAC data, genetically predicted BMI was found to be inversely associated with breast cancer risk (odds ratio [OR]  =  0.65 per 5 kg/m<sup>2</sup>
 increase, 95% confidence interval [CI]: 0.56–0.75, <italic>p</italic>
 = 3.32 × 10<sup>−10</sup>
). The associations were similar for both premenopausal (OR   =   0.44, 95% CI:0.31–0.62, <italic>p</italic>
  =  9.91 × 10<sup>−8</sup>
) and postmenopausal breast cancer (OR  =  0.57, 95% CI: 0.46–0.71, <italic>p</italic>
  =  1.88 × 10<sup>−8</sup>
). This association was replicated in the data from the DRIVE consortium (OR  =  0.72, 95% CI: 0.60–0.84, <italic>p</italic>
   =   1.64 × 10<sup>−7</sup>
). Single marker analyses identified 17 of the 84 BMI-associated single nucleotide polymorphisms (SNPs) in association with breast cancer risk at <italic>p</italic>
 < 0.05; for 16 of them, the allele associated with elevated BMI was associated with reduced breast cancer risk.</p>
</sec>
<sec id="sec004"><title>Conclusions</title>
<p>BMI predicted by genome-wide association studies (GWAS)-identified variants is inversely associated with the risk of both pre- and postmenopausal breast cancer. The reduced risk of postmenopausal breast cancer associated with genetically predicted BMI observed in this study differs from the positive association reported from studies using measured adult BMI. Understanding the reasons for this discrepancy may reveal insights into the complex relationship of genetic determinants of body weight in the etiology of breast cancer.</p>
</sec>
</abstract>
<abstract abstract-type="toc"><p>Using Mendelian randomization analysis, Wei Zheng and colleagues probe potentially causal associations between BMI and breast cancer risk in both pre- and postmenopausal women.</p>
</abstract>
<abstract abstract-type="summary"><title>Author Summary</title>
<sec id="sec005"><title>Why Was This Study Done?</title>
<list list-type="bullet"><list-item><p>Body mass index (BMI) has been linked to breast cancer risk in conventional population studies.</p>
</list-item>
<list-item><p>In these studies, high BMI is associated with reduced risk of breast cancer in premenopausal women but with increased risk in postmenopausal women. These changed risks may be caused by BMI or caused by environmental factors that are associated with BMI.</p>
</list-item>
<list-item><p>We sought to use a research tool from the genetics field to understand BMI’s causal role in breast cancer.</p>
</list-item>
</list>
</sec>
<sec id="sec006"><title>What Did the Researchers Do and Find?</title>
<list list-type="bullet"><list-item><p>We took advantage of previously identified genetic sequence variations that are associated with BMI in European populations and used these variants to predict BMI. These variants are set at birth and are not affected by environmental factors; thus, outcomes associated with high BMI as predicted by genetic variants are more likely to be caused by high BMI itself rather than by environmental factors that are associated with high BMI.</p>
</list-item>
<list-item><p>Using databases containing individual genetic sequences and breast cancer diagnoses in a European population, we tested whether genetically predicted BMI was associated with diagnosis of breast cancer in either pre- or postmenopausal women.</p>
</list-item>
<list-item><p>We found that genetically predicted high BMI was associated with decreased breast cancer risk, in both cancer databases. Unexpectedly, this was true for both pre- and postmenopausal women.</p>
</list-item>
</list>
</sec>
<sec id="sec007"><title>What Do These Findings Mean?</title>
<list list-type="bullet"><list-item><p>Our results from postmenopausal women contradict prior findings from population studies, which used measured, rather than genetically predicted, BMI.</p>
</list-item>
<list-item><p>BMI predicted using genetic variants identified to date may be more closely related to body weight in early life or midlife, which is negatively associated with risk of breast cancer. Measured high BMI later in life may be influenced by environmental factors that are associated with increased risk of breast cancer.</p>
</list-item>
<list-item><p>More research is needed on the interrelationship of genetic factors, environment, and BMI in the risk of breast cancer.</p>
</list-item>
</list>
</sec>
</abstract>
<funding-group><award-group id="award001"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/100000054</institution-id>
<institution>National Cancer Institute</institution>
</institution-wrap>
</funding-source>
<award-id>R37CA070867</award-id>
<principal-award-recipient><name><surname>Zheng</surname>
<given-names>Wei</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award002"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/100000054</institution-id>
<institution>National Cancer Institute</institution>
</institution-wrap>
</funding-source>
<award-id>R25CA160056</award-id>
<principal-award-recipient><name><surname>Shu</surname>
<given-names>Xiao-Ou</given-names>
</name>
</principal-award-recipient>
</award-group>
<funding-statement>The work conducted for this project at Vanderbilt University is supported primarily by National Cancer Institute research grants (R37CA070867 and R25CA160056) and endowment funds for the Ingram Professorship and Anne Potter Wilson Chair. JF is a volunteer for the NCI in the Epidemiology and Biostatistics Program and has no role in funding decisions. A complete funding statement is available in the Supporting Information. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="2"></fig-count>
<table-count count="3"></table-count>
<page-count count="18"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>The GAME-ON summary statistics are free to access (<ext-link ext-link-type="uri" xlink:href="http://epi.grants.cancer.gov/gameon/">http://epi.grants.cancer.gov/gameon/</ext-link>
). To request the data from the Breast Cancer Association Consortium (BCAC), readers are instructed to submit a concept proposal, which will be reviewed by the BCAC Data Access Coordination Committee (DACC) (<ext-link ext-link-type="uri" xlink:href="http://ccge.medschl.cam.ac.uk/consortia/bcac/">http://ccge.medschl.cam.ac.uk/consortia/bcac/</ext-link>
). Over the past seven years, more than 500 concept proposals have been approved, including many from non-BCAC investigators.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>The GAME-ON summary statistics are free to access (<ext-link ext-link-type="uri" xlink:href="http://epi.grants.cancer.gov/gameon/">http://epi.grants.cancer.gov/gameon/</ext-link>
). To request the data from the Breast Cancer Association Consortium (BCAC), readers are instructed to submit a concept proposal, which will be reviewed by the BCAC Data Access Coordination Committee (DACC) (<ext-link ext-link-type="uri" xlink:href="http://ccge.medschl.cam.ac.uk/consortia/bcac/">http://ccge.medschl.cam.ac.uk/consortia/bcac/</ext-link>
). Over the past seven years, more than 500 concept proposals have been approved, including many from non-BCAC investigators.</p>
</notes>
</front>
</pmc>
</record>

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Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

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