Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
Identifieur interne : 002731 ( Pmc/Curation ); précédent : 002730; suivant : 002732Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
Auteurs : Cristian Pattaro [Italie] ; Anna Köttgen [États-Unis, Allemagne] ; Alexander Teumer [Allemagne] ; Maija Garnaas [États-Unis] ; Carsten A. Böger [Allemagne] ; Christian Fuchsberger [États-Unis] ; Matthias Olden [Allemagne] ; Ming-Huei Chen [États-Unis] ; Adrienne Tin [États-Unis] ; Daniel Taliun [Italie] ; Man Li [États-Unis] ; Xiaoyi Gao [États-Unis] ; Mathias Gorski [Allemagne] ; Qiong Yang [États-Unis] ; Claudia Hundertmark [Allemagne] ; Meredith C. Foster [États-Unis] ; Conall M. O'Seaghdha [États-Unis] ; Nicole Glazer [États-Unis] ; Aaron Isaacs [Pays-Bas] ; Ching-Ti Liu [États-Unis] ; Albert V. Smith [Islande] ; Jeffrey R. O'Connell [États-Unis] ; Maksim Struchalin [Pays-Bas] ; Toshiko Tanaka [États-Unis] ; Guo Li [États-Unis] ; Andrew D. Johnson [États-Unis] ; Hinco J. Gierman [États-Unis] ; Mary Feitosa [États-Unis] ; Shih-Jen Hwang [États-Unis] ; Elizabeth J. Atkinson [États-Unis] ; Kurt Lohman [États-Unis] ; Marilyn C. Cornelis [États-Unis] ; Sa Johansson [Suède] ; Anke Tönjes [Allemagne] ; Abbas Dehghan [Pays-Bas] ; Vincent Chouraki [France] ; Elizabeth G. Holliday [Australie] ; Rossella Sorice [Italie] ; Zoltan Kutalik [Suisse] ; Terho Lehtim Ki [Finlande] ; T Nu Esko [Estonie] ; Harshal Deshmukh [Royaume-Uni] ; Sheila Ulivi [Italie] ; Audrey Y. Chu [États-Unis] ; Federico Murgia [Italie] ; Stella Trompet [Pays-Bas] ; Medea Imboden [Suisse] ; Barbara Kollerits [Autriche] ; Giorgio Pistis [Italie] ; Tamara B. Harris [États-Unis] ; Lenore J. Launer [États-Unis] ; Thor Aspelund [Islande] ; Gudny Eiriksdottir [Islande] ; Braxton D. Mitchell [États-Unis] ; Eric Boerwinkle [États-Unis] ; Helena Schmidt [Autriche] ; Margherita Cavalieri [Autriche] ; Madhumathi Rao [États-Unis] ; Frank B. Hu [États-Unis] ; Ayse Demirkan [Pays-Bas] ; Ben A. Oostra [Pays-Bas] ; Mariza De Andrade [États-Unis] ; Stephen T. Turner [États-Unis] ; Jingzhong Ding [États-Unis] ; Jeanette S. Andrews [États-Unis] ; Barry I. Freedman [États-Unis] ; Wolfgang Koenig [Allemagne] ; Thomas Illig [Allemagne] ; Angela Döring [Allemagne] ; H.-Erich Wichmann [Allemagne] ; Ivana Kolcic [Croatie] ; Tatijana Zemunik [Croatie] ; Mladen Boban [Croatie] ; Cosetta Minelli [Italie] ; Heather E. Wheeler [États-Unis] ; Wilmar Igl [Suède] ; Ghazal Zaboli [Suède] ; Sarah H. Wild [Royaume-Uni] ; Alan F. Wright [Royaume-Uni] ; Harry Campbell [Royaume-Uni] ; David Ellinghaus [Allemagne] ; Ute Nöthlings [Allemagne] ; Gunnar Jacobs [Allemagne] ; Reiner Biffar [Allemagne] ; Karlhans Endlich [Allemagne] ; Florian Ernst [Allemagne] ; Georg Homuth [Allemagne] ; Heyo K. Kroemer [Allemagne] ; Matthias Nauck [Allemagne] ; Sylvia Stracke [Allemagne] ; Uwe Völker [Allemagne] ; Henry Völzke [Allemagne] ; Peter Kovacs [Allemagne] ; Michael Stumvoll [Allemagne] ; Reedik M Gi [Estonie, Royaume-Uni] ; Albert Hofman [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; Fernando Rivadeneira [Pays-Bas] ; Yurii S. Aulchenko [Pays-Bas] ; Ozren Polasek [Croatie] ; Nick Hastie [Royaume-Uni] ; Veronique Vitart [Royaume-Uni] ; Catherine Helmer [France] ; Jie Jin Wang [Australie] ; Daniela Ruggiero [Italie] ; Sven Bergmann [Suisse] ; Mika K Hönen [Finlande] ; Jorma Viikari [Finlande] ; Tiit Nikopensius [Estonie] ; Michael Province [États-Unis] ; Shamika Ketkar [États-Unis] ; Helen Colhoun [Royaume-Uni] ; Alex Doney [Royaume-Uni] ; Antonietta Robino [Italie] ; Franco Giulianini [États-Unis] ; Bernhard K. Kr Mer [Allemagne] ; Laura Portas [Italie] ; Ian Ford [Royaume-Uni] ; Brendan M. Buckley [Irlande (pays)] ; Martin Adam [Suisse] ; Gian-Andri Thun [Suisse] ; Bernhard Paulweber [Autriche] ; Margot Haun [Autriche] ; Cinzia Sala [Italie] ; Marie Metzger [France] ; Paul Mitchell [Australie] ; Marina Ciullo [Italie] ; Stuart K. Kim [États-Unis] ; Peter Vollenweider [Suisse] ; Olli Raitakari [Finlande] ; Andres Metspalu [Estonie] ; Colin Palmer [Royaume-Uni] ; Paolo Gasparini [Italie] ; Mario Pirastu [Italie] ; J. Wouter Jukema [Pays-Bas] ; Nicole M. Probst-Hensch [Suisse] ; Florian Kronenberg [Autriche] ; Daniela Toniolo [Italie] ; Vilmundur Gudnason [Islande] ; Alan R. Shuldiner [États-Unis] ; Josef Coresh [États-Unis] ; Reinhold Schmidt [Autriche] ; Luigi Ferrucci [États-Unis] ; David S. Siscovick [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Ingrid Borecki [États-Unis] ; Sharon L. R. Kardia [États-Unis] ; Yongmei Liu [États-Unis] ; Gary C. Curhan [États-Unis] ; Igor Rudan [Royaume-Uni] ; Ulf Gyllensten [Suède] ; James F. Wilson [Royaume-Uni] ; Andre Franke [Allemagne] ; Peter P. Pramstaller [Italie] ; Rainer Rettig [Allemagne] ; Inga Prokopenko [Royaume-Uni] ; Jacqueline C. M. Witteman [Pays-Bas] ; Caroline Hayward [Royaume-Uni] ; Paul Ridker [États-Unis] ; Afshin Parsa [États-Unis] ; Murielle Bochud [Suisse] ; Iris M. Heid [Allemagne] ; Wolfram Goessling [États-Unis] ; Daniel I. Chasman [États-Unis] ; W. H. Linda Kao [États-Unis] ; Caroline S. Fox [États-Unis]Source :
- PLoS Genetics [ 1553-7390 ] ; 2012.
Abstract
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near
Url:
DOI: 10.1371/journal.pgen.1002584
PubMed: 22479191
PubMed Central: 3315455
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id="aff10"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, 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id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Xiaoyi" sort="Gao, Xiaoyi" uniqKey="Gao X" first="Xiaoyi" last="Gao">Xiaoyi Gao</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias 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Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>Renal Division, Freiburg University Clinic, Freiburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Renal Division, Freiburg University Clinic, Freiburg</wicri:regionArea></affiliation></author><author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. 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O'Seaghdha</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><addr-line>Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name><affiliation wicri:level="1"><nlm:aff id="aff19"><addr-line>Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff21"><addr-line>Centre for Medical Systems Biology, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for Medical Systems Biology, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><affiliation wicri:level="1"><nlm:aff id="aff22"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="1"><nlm:aff id="aff26"><addr-line>Department of Epidemiology and Biostatistics and Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics and Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation wicri:level="1"><nlm:aff id="aff28"><addr-line>University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Gierman, Hinco J" sort="Gierman, Hinco J" uniqKey="Gierman H" first="Hinco J." last="Gierman">Hinco J. Gierman</name><affiliation wicri:level="1"><nlm:aff id="aff29"><addr-line>Department of Developmental Biology, Stanford University, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Biology, Stanford University, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Feitosa, Mary" sort="Feitosa, Mary" uniqKey="Feitosa M" first="Mary" last="Feitosa">Mary Feitosa</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><affiliation wicri:level="1"><nlm:aff id="aff30"><addr-line>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation wicri:level="1"><nlm:aff id="aff31"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name><affiliation wicri:level="1"><nlm:aff id="aff32"><addr-line>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation wicri:level="1"><nlm:aff id="aff34"><addr-line>Department of Medicine, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff35"><addr-line>IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>IFB Adiposity Diseases, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="aff37"><addr-line>Inserm UMR744, Institut Pasteur, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR744, Institut Pasteur, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="aff38"><addr-line>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Centre for Information-based Medicine, Hunter Medical Research Institute, Newcastle, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Information-based Medicine, Hunter Medical Research Institute, Newcastle</wicri:regionArea></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation wicri:level="1"><nlm:aff id="aff41"><addr-line>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, Lausanne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Swiss Institute of Bioinformatics, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="aff43"><addr-line>Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Centre for Laboratory Medicine Tampere Finn-Medi 2, Tampere, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Centre for Laboratory Medicine Tampere Finn-Medi 2, Tampere</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu (EGCUT), Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45"><addr-line>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name><affiliation wicri:level="1"><nlm:aff id="aff46"><addr-line>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation wicri:level="1"><nlm:aff id="aff47"><addr-line>Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Institute of Population Genetics – CNR, Sassari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics – CNR, Sassari</wicri:regionArea></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="1"><nlm:aff id="aff50"><addr-line>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation wicri:level="1"><nlm:aff id="aff53"><addr-line>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="aff54"><addr-line>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="aff54"><addr-line>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="1"><nlm:aff id="aff55"><addr-line>Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff56"><addr-line>Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><affiliation wicri:level="1"><nlm:aff id="aff57"><addr-line>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name><affiliation wicri:level="1"><nlm:aff id="aff58"><addr-line>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation wicri:level="1"><nlm:aff id="aff32"><addr-line>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation wicri:level="1"><nlm:aff id="aff30"><addr-line>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation wicri:level="1"><nlm:aff id="aff59"><addr-line>Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><affiliation wicri:level="1"><nlm:aff id="aff60"><addr-line>Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name><affiliation wicri:level="1"><nlm:aff id="aff61"><addr-line>Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><affiliation wicri:level="1"><nlm:aff id="aff62"><addr-line>Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation wicri:level="1"><nlm:aff id="aff63"><addr-line>Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Abteilung Innere II, Universitätsklinikum Ulm, Ulm</wicri:regionArea></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="1"><nlm:aff id="aff64"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff64"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff65"><addr-line>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff66"><addr-line>Klinikum Grosshadern, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Grosshadern, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano</wicri:regionArea></affiliation></author><author><name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name><affiliation wicri:level="1"><nlm:aff id="aff68"><addr-line>Department of Genetics, Stanford University, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Stanford University, Stanford, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff69"><addr-line>Department of Medicine, University of Chicago, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Chicago, Chicago, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name><affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff73"><addr-line>popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>popgen Biobank, University Hospital Schleswig-Holstein, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff73"><addr-line>popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>popgen Biobank, University Hospital Schleswig-Holstein, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation wicri:level="1"><nlm:aff id="aff74"><addr-line>Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation wicri:level="1"><nlm:aff id="aff75"><addr-line>Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name><affiliation wicri:level="1"><nlm:aff id="aff76"><addr-line>Institute of Pharmacology, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmacology, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation wicri:level="1"><nlm:aff id="aff77"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><affiliation wicri:level="1"><nlm:aff id="aff78"><addr-line>Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for Internal Medicine A, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="aff79"><addr-line>Institute for Community Medicine, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Department of Medicine, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation wicri:level="1"><nlm:aff id="aff34"><addr-line>Department of Medicine, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff35"><addr-line>IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>IFB Adiposity Diseases, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu (EGCUT), Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff81"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="aff82"><addr-line>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="aff82"><addr-line>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="aff83"><addr-line>Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name><affiliation wicri:level="1"><nlm:aff id="aff84"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:aff id="aff84"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation wicri:level="1"><nlm:aff id="aff85"><addr-line>INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED, Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff86"><addr-line>Université Bordeaux 2 Victor Segalen, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux 2 Victor Segalen, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff87"><addr-line>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff88"><addr-line>Centre for Eye Research Australia (CERA), University of Melbourne, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia (CERA), University of Melbourne, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Swiss Institute of Bioinformatics, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="aff89"><addr-line>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere</wicri:regionArea></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation wicri:level="1"><nlm:aff id="aff90"><addr-line>Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medicine, University of Turku and Turku University Hospital, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name><affiliation wicri:level="1"><nlm:aff id="aff45"><addr-line>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name><affiliation wicri:level="1"><nlm:aff id="aff46"><addr-line>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name><affiliation wicri:level="1"><nlm:aff id="aff91"><addr-line>NHS Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:aff id="aff92"><addr-line>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><affiliation wicri:level="1"><nlm:aff id="aff93"><addr-line>University Medical Centre Mannheim, 5th Department of Medicine, Mannheim, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Centre Mannheim, 5th Department of Medicine, Mannheim</wicri:regionArea></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Institute of Population Genetics – CNR, Sassari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics – CNR, Sassari</wicri:regionArea></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="1"><nlm:aff id="aff94"><addr-line>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name><affiliation wicri:level="1"><nlm:aff id="aff95"><addr-line>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</addr-line></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University College Cork, Cork</wicri:regionArea></affiliation></author><author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation wicri:level="1"><nlm:aff id="aff96"><addr-line>First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>First Department of Internal Medicine, Paracelsus Medical University, Salzburg</wicri:regionArea></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation wicri:level="1"><nlm:aff id="aff97"><addr-line>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="aff53"><addr-line>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><affiliation wicri:level="1"><nlm:aff id="aff98"><addr-line>Inserm UMRS 1018, CESP Team 10, Université Paris Sud, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMRS 1018, CESP Team 10, Université Paris Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="1"><nlm:aff id="aff87"><addr-line>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Stuart K" sort="Kim, Stuart K" uniqKey="Kim S" first="Stuart K." last="Kim">Stuart K. Kim</name><affiliation wicri:level="1"><nlm:aff id="aff29"><addr-line>Department of Developmental Biology, Stanford University, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Biology, Stanford University, Stanford, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff68"><addr-line>Department of Genetics, Stanford University, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Stanford University, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:aff id="aff99"><addr-line>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, Turku University Hospital, University of Turku, Turku, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, Turku University Hospital, University of Turku, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu (EGCUT), Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45"><addr-line>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name><affiliation wicri:level="1"><nlm:aff id="aff101"><addr-line>Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation wicri:level="1"><nlm:aff id="aff92"><addr-line>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Institute of Population Genetics – CNR, Sassari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics – CNR, Sassari</wicri:regionArea></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation wicri:level="1"><nlm:aff id="aff50"><addr-line>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff102"><addr-line>Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff103"><addr-line>Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Einthoven Laboratory for Experimental Vascular Medicine, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff104"><addr-line>Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Durrer Center for Cardiogenetic Research, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation wicri:level="1"><nlm:aff id="aff53"><addr-line>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff105"><addr-line>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106"><addr-line>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff57"><addr-line>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation wicri:level="1"><nlm:aff id="aff28"><addr-line>University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Borecki, Ingrid" sort="Borecki, Ingrid" uniqKey="Borecki I" first="Ingrid" last="Borecki">Ingrid Borecki</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation wicri:level="1"><nlm:aff id="aff107"><addr-line>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="1"><nlm:aff id="aff31"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name><affiliation wicri:level="1"><nlm:aff id="aff108"><addr-line>Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano</wicri:regionArea></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation wicri:level="1"><nlm:aff id="aff109"><addr-line>Institute of Physiology, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Physiology, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><nlm:aff id="aff81"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="aff84"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff110"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation wicri:level="1"><nlm:aff id="aff111"><addr-line>Division of Nephrology, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Maryland Medical School, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation wicri:level="1"><nlm:aff id="aff112"><addr-line>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges</wicri:regionArea></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation wicri:level="1"><nlm:aff id="aff113"><addr-line>Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff114"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><affiliation wicri:level="1"><nlm:aff id="aff115"><addr-line>Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff116"><addr-line>Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff110"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106"><addr-line>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff117"><addr-line>Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22479191</idno><idno type="pmc">3315455</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315455</idno><idno type="RBID">PMC:3315455</idno><idno type="doi">10.1371/journal.pgen.1002584</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002881</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002881</idno><idno type="wicri:Area/Pmc/Curation">002731</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002731</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function</title><author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano</wicri:regionArea></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Renal Division, Freiburg University Clinic, Freiburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Renal Division, Freiburg University Clinic, Freiburg</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Garnaas, Maija" sort="Garnaas, Maija" uniqKey="Garnaas M" first="Maija" last="Garnaas">Maija Garnaas</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, University Medical Center Regensburg, Regensburg</wicri:regionArea></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, University Hospital Regensburg, Regensburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation wicri:level="1"><nlm:aff id="aff10"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano</wicri:regionArea></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Xiaoyi" sort="Gao, Xiaoyi" uniqKey="Gao X" first="Xiaoyi" last="Gao">Xiaoyi Gao</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>Renal Division, Freiburg University Clinic, Freiburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Renal Division, Freiburg University Clinic, Freiburg</wicri:regionArea></affiliation></author><author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. Foster</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="O Seaghdha, Conall M" sort="O Seaghdha, Conall M" uniqKey="O Seaghdha C" first="Conall M." last="O'Seaghdha">Conall M. O'Seaghdha</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><addr-line>Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name><affiliation wicri:level="1"><nlm:aff id="aff19"><addr-line>Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff21"><addr-line>Centre for Medical Systems Biology, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for Medical Systems Biology, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name><affiliation wicri:level="1"><nlm:aff id="aff22"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="1"><nlm:aff id="aff26"><addr-line>Department of Epidemiology and Biostatistics and Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics and Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation wicri:level="1"><nlm:aff id="aff28"><addr-line>University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Gierman, Hinco J" sort="Gierman, Hinco J" uniqKey="Gierman H" first="Hinco J." last="Gierman">Hinco J. Gierman</name><affiliation wicri:level="1"><nlm:aff id="aff29"><addr-line>Department of Developmental Biology, Stanford University, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Biology, Stanford University, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Feitosa, Mary" sort="Feitosa, Mary" uniqKey="Feitosa M" first="Mary" last="Feitosa">Mary Feitosa</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><affiliation wicri:level="1"><nlm:aff id="aff30"><addr-line>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation wicri:level="1"><nlm:aff id="aff31"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name><affiliation wicri:level="1"><nlm:aff id="aff32"><addr-line>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation wicri:level="1"><nlm:aff id="aff34"><addr-line>Department of Medicine, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff35"><addr-line>IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>IFB Adiposity Diseases, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="aff37"><addr-line>Inserm UMR744, Institut Pasteur, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR744, Institut Pasteur, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="aff38"><addr-line>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Centre for Information-based Medicine, Hunter Medical Research Institute, Newcastle, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Information-based Medicine, Hunter Medical Research Institute, Newcastle</wicri:regionArea></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation wicri:level="1"><nlm:aff id="aff41"><addr-line>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, Lausanne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Swiss Institute of Bioinformatics, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="aff43"><addr-line>Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Centre for Laboratory Medicine Tampere Finn-Medi 2, Tampere, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Centre for Laboratory Medicine Tampere Finn-Medi 2, Tampere</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu (EGCUT), Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45"><addr-line>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name><affiliation wicri:level="1"><nlm:aff id="aff46"><addr-line>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation wicri:level="1"><nlm:aff id="aff47"><addr-line>Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Institute of Population Genetics – CNR, Sassari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics – CNR, Sassari</wicri:regionArea></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="1"><nlm:aff id="aff50"><addr-line>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation wicri:level="1"><nlm:aff id="aff53"><addr-line>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="aff54"><addr-line>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="aff54"><addr-line>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="1"><nlm:aff id="aff55"><addr-line>Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff56"><addr-line>Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><affiliation wicri:level="1"><nlm:aff id="aff57"><addr-line>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name><affiliation wicri:level="1"><nlm:aff id="aff58"><addr-line>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation wicri:level="1"><nlm:aff id="aff32"><addr-line>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation wicri:level="1"><nlm:aff id="aff30"><addr-line>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation wicri:level="1"><nlm:aff id="aff59"><addr-line>Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><affiliation wicri:level="1"><nlm:aff id="aff60"><addr-line>Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name><affiliation wicri:level="1"><nlm:aff id="aff61"><addr-line>Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><affiliation wicri:level="1"><nlm:aff id="aff62"><addr-line>Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation wicri:level="1"><nlm:aff id="aff63"><addr-line>Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Abteilung Innere II, Universitätsklinikum Ulm, Ulm</wicri:regionArea></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="1"><nlm:aff id="aff64"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff64"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff65"><addr-line>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff66"><addr-line>Klinikum Grosshadern, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Grosshadern, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano</wicri:regionArea></affiliation></author><author><name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name><affiliation wicri:level="1"><nlm:aff id="aff68"><addr-line>Department of Genetics, Stanford University, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Stanford University, Stanford, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff69"><addr-line>Department of Medicine, University of Chicago, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Chicago, Chicago, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name><affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff73"><addr-line>popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>popgen Biobank, University Hospital Schleswig-Holstein, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff73"><addr-line>popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>popgen Biobank, University Hospital Schleswig-Holstein, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation wicri:level="1"><nlm:aff id="aff74"><addr-line>Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation wicri:level="1"><nlm:aff id="aff75"><addr-line>Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name><affiliation wicri:level="1"><nlm:aff id="aff76"><addr-line>Institute of Pharmacology, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmacology, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation wicri:level="1"><nlm:aff id="aff77"><addr-line>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><affiliation wicri:level="1"><nlm:aff id="aff78"><addr-line>Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for Internal Medicine A, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="aff79"><addr-line>Institute for Community Medicine, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Department of Medicine, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation wicri:level="1"><nlm:aff id="aff34"><addr-line>Department of Medicine, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff35"><addr-line>IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>IFB Adiposity Diseases, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu (EGCUT), Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff81"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="aff82"><addr-line>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="aff82"><addr-line>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="aff83"><addr-line>Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name><affiliation wicri:level="1"><nlm:aff id="aff84"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:aff id="aff84"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation wicri:level="1"><nlm:aff id="aff85"><addr-line>INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED, Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff86"><addr-line>Université Bordeaux 2 Victor Segalen, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux 2 Victor Segalen, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff87"><addr-line>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff88"><addr-line>Centre for Eye Research Australia (CERA), University of Melbourne, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia (CERA), University of Melbourne, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Swiss Institute of Bioinformatics, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="aff89"><addr-line>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere</wicri:regionArea></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation wicri:level="1"><nlm:aff id="aff90"><addr-line>Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medicine, University of Turku and Turku University Hospital, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name><affiliation wicri:level="1"><nlm:aff id="aff45"><addr-line>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name><affiliation wicri:level="1"><nlm:aff id="aff46"><addr-line>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name><affiliation wicri:level="1"><nlm:aff id="aff91"><addr-line>NHS Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:aff id="aff92"><addr-line>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><affiliation wicri:level="1"><nlm:aff id="aff93"><addr-line>University Medical Centre Mannheim, 5th Department of Medicine, Mannheim, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Centre Mannheim, 5th Department of Medicine, Mannheim</wicri:regionArea></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Institute of Population Genetics – CNR, Sassari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics – CNR, Sassari</wicri:regionArea></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="1"><nlm:aff id="aff94"><addr-line>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name><affiliation wicri:level="1"><nlm:aff id="aff95"><addr-line>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</addr-line></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University College Cork, Cork</wicri:regionArea></affiliation></author><author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation wicri:level="1"><nlm:aff id="aff96"><addr-line>First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>First Department of Internal Medicine, Paracelsus Medical University, Salzburg</wicri:regionArea></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation wicri:level="1"><nlm:aff id="aff97"><addr-line>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="aff53"><addr-line>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><affiliation wicri:level="1"><nlm:aff id="aff98"><addr-line>Inserm UMRS 1018, CESP Team 10, Université Paris Sud, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMRS 1018, CESP Team 10, Université Paris Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="1"><nlm:aff id="aff87"><addr-line>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Stuart K" sort="Kim, Stuart K" uniqKey="Kim S" first="Stuart K." last="Kim">Stuart K. Kim</name><affiliation wicri:level="1"><nlm:aff id="aff29"><addr-line>Department of Developmental Biology, Stanford University, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Biology, Stanford University, Stanford, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff68"><addr-line>Department of Genetics, Stanford University, Stanford, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Stanford University, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:aff id="aff99"><addr-line>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, Turku University Hospital, University of Turku, Turku, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, Turku University Hospital, University of Turku, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu (EGCUT), Tartu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45"><addr-line>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</addr-line></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name><affiliation wicri:level="1"><nlm:aff id="aff101"><addr-line>Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation wicri:level="1"><nlm:aff id="aff92"><addr-line>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Institute of Population Genetics – CNR, Sassari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics – CNR, Sassari</wicri:regionArea></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation wicri:level="1"><nlm:aff id="aff50"><addr-line>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff102"><addr-line>Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff103"><addr-line>Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Einthoven Laboratory for Experimental Vascular Medicine, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff104"><addr-line>Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Durrer Center for Cardiogenetic Research, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation wicri:level="1"><nlm:aff id="aff51"><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation wicri:level="1"><nlm:aff id="aff53"><addr-line>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24"><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation wicri:level="1"><nlm:aff id="aff25"><addr-line>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff105"><addr-line>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106"><addr-line>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff57"><addr-line>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="aff27"><addr-line>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation wicri:level="1"><nlm:aff id="aff28"><addr-line>University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="aff20"><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Borecki, Ingrid" sort="Borecki, Ingrid" uniqKey="Borecki I" first="Ingrid" last="Borecki">Ingrid Borecki</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation wicri:level="1"><nlm:aff id="aff107"><addr-line>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="1"><nlm:aff id="aff31"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name><affiliation wicri:level="1"><nlm:aff id="aff108"><addr-line>Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano</wicri:regionArea></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation wicri:level="1"><nlm:aff id="aff109"><addr-line>Institute of Physiology, University of Greifswald, Greifswald, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Physiology, University of Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><nlm:aff id="aff81"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name><affiliation wicri:level="1"><nlm:aff id="aff36"><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="aff84"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff110"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation wicri:level="1"><nlm:aff id="aff111"><addr-line>Division of Nephrology, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Maryland Medical School, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation wicri:level="1"><nlm:aff id="aff112"><addr-line>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges</wicri:regionArea></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation wicri:level="1"><nlm:aff id="aff113"><addr-line>Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff114"><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><affiliation wicri:level="1"><nlm:aff id="aff115"><addr-line>Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff116"><addr-line>Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff110"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106"><addr-line>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff117"><addr-line>Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS Genetics</title><idno type="ISSN">1553-7390</idno><idno type="eISSN">1553-7404</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near <italic>MPPED2</italic>, <italic>DDX1</italic>, <italic>SLC47A1</italic>, <italic>CDK12</italic>, <italic>CASP9</italic>, and <italic>INO80</italic>. Morpholino knockdown of <italic>mpped2</italic> and <italic>casp9</italic> in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. 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article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Genet</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Genet</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosgen</journal-id><journal-title-group><journal-title>PLoS Genetics</journal-title></journal-title-group><issn pub-type="ppub">1553-7390</issn><issn pub-type="epub">1553-7404</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22479191</article-id><article-id pub-id-type="pmc">3315455</article-id><article-id pub-id-type="publisher-id">PGENETICS-D-11-02100</article-id><article-id pub-id-type="doi">10.1371/journal.pgen.1002584</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject><subj-group><subject>Genetics</subject></subj-group></subj-group></article-categories><title-group><article-title>Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function</article-title><alt-title alt-title-type="running-head">GWAS Reveals New Loci for Kidney Function</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Pattaro</surname><given-names>Cristian</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Köttgen</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Teumer</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Garnaas</surname><given-names>Maija</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Böger</surname><given-names>Carsten A.</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fuchsberger</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Olden</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Ming-Huei</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tin</surname><given-names>Adrienne</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Taliun</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Man</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Xiaoyi</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gorski</surname><given-names>Mathias</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref><xref ref-type="aff" rid="aff14"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Qiong</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hundertmark</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Foster</surname><given-names>Meredith C.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>O'Seaghdha</surname><given-names>Conall M.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref><xref ref-type="aff" rid="aff18"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Glazer</surname><given-names>Nicole</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Isaacs</surname><given-names>Aaron</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Ching-Ti</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Albert V.</given-names></name><xref ref-type="aff" rid="aff23"><sup>23</sup></xref><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>O'Connell</surname><given-names>Jeffrey R.</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Struchalin</surname><given-names>Maksim</given-names></name><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tanaka</surname><given-names>Toshiko</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Guo</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Andrew D.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gierman</surname><given-names>Hinco J.</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Feitosa</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hwang</surname><given-names>Shih-Jen</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Atkinson</surname><given-names>Elizabeth J.</given-names></name><xref ref-type="aff" rid="aff30"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lohman</surname><given-names>Kurt</given-names></name><xref ref-type="aff" rid="aff31"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cornelis</surname><given-names>Marilyn C.</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johansson</surname><given-names>Åsa</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tönjes</surname><given-names>Anke</given-names></name><xref ref-type="aff" rid="aff34"><sup>34</sup></xref><xref ref-type="aff" rid="aff35"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dehghan</surname><given-names>Abbas</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib 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contrib-type="author"><name><surname>Schmidt</surname><given-names>Helena</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cavalieri</surname><given-names>Margherita</given-names></name><xref ref-type="aff" rid="aff57"><sup>57</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rao</surname><given-names>Madhumathi</given-names></name><xref ref-type="aff" rid="aff58"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Frank B.</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Demirkan</surname><given-names>Ayse</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Oostra</surname><given-names>Ben A.</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>de Andrade</surname><given-names>Mariza</given-names></name><xref ref-type="aff" rid="aff30"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Turner</surname><given-names>Stephen T.</given-names></name><xref ref-type="aff" rid="aff59"><sup>59</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Jingzhong</given-names></name><xref ref-type="aff" rid="aff60"><sup>60</sup></xref></contrib><contrib contrib-type="author"><name><surname>Andrews</surname><given-names>Jeanette S.</given-names></name><xref ref-type="aff" rid="aff61"><sup>61</sup></xref></contrib><contrib contrib-type="author"><name><surname>Freedman</surname><given-names>Barry I.</given-names></name><xref ref-type="aff" rid="aff62"><sup>62</sup></xref></contrib><contrib contrib-type="author"><name><surname>Koenig</surname><given-names>Wolfgang</given-names></name><xref ref-type="aff" rid="aff63"><sup>63</sup></xref></contrib><contrib contrib-type="author"><name><surname>Illig</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="aff64"><sup>64</sup></xref></contrib><contrib contrib-type="author"><name><surname>Döring</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref><xref ref-type="aff" rid="aff64"><sup>64</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wichmann</surname><given-names>H.-Erich</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref><xref ref-type="aff" rid="aff65"><sup>65</sup></xref><xref ref-type="aff" rid="aff66"><sup>66</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kolcic</surname><given-names>Ivana</given-names></name><xref ref-type="aff" rid="aff67"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zemunik</surname><given-names>Tatijana</given-names></name><xref ref-type="aff" rid="aff67"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boban</surname><given-names>Mladen</given-names></name><xref ref-type="aff" rid="aff67"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Minelli</surname><given-names>Cosetta</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wheeler</surname><given-names>Heather E.</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref><xref ref-type="aff" rid="aff69"><sup>69</sup></xref></contrib><contrib contrib-type="author"><name><surname>Igl</surname><given-names>Wilmar</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zaboli</surname><given-names>Ghazal</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wild</surname><given-names>Sarah H.</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Alan F.</given-names></name><xref ref-type="aff" rid="aff71"><sup>71</sup></xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Harry</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ellinghaus</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nöthlings</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref><xref ref-type="aff" rid="aff73"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jacobs</surname><given-names>Gunnar</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref><xref ref-type="aff" rid="aff73"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Biffar</surname><given-names>Reiner</given-names></name><xref ref-type="aff" rid="aff74"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>Endlich</surname><given-names>Karlhans</given-names></name><xref ref-type="aff" rid="aff75"><sup>75</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ernst</surname><given-names>Florian</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Homuth</surname><given-names>Georg</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kroemer</surname><given-names>Heyo K.</given-names></name><xref ref-type="aff" rid="aff76"><sup>76</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nauck</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="aff77"><sup>77</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stracke</surname><given-names>Sylvia</given-names></name><xref ref-type="aff" rid="aff78"><sup>78</sup></xref></contrib><contrib contrib-type="author"><name><surname>Völker</surname><given-names>Uwe</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Völzke</surname><given-names>Henry</given-names></name><xref ref-type="aff" rid="aff79"><sup>79</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kovacs</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff80"><sup>80</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stumvoll</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff34"><sup>34</sup></xref><xref ref-type="aff" rid="aff35"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mägi</surname><given-names>Reedik</given-names></name><xref ref-type="aff" rid="aff44"><sup>44</sup></xref><xref ref-type="aff" rid="aff81"><sup>81</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hofman</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Uitterlinden</surname><given-names>Andre G.</given-names></name><xref ref-type="aff" rid="aff82"><sup>82</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rivadeneira</surname><given-names>Fernando</given-names></name><xref ref-type="aff" rid="aff82"><sup>82</sup></xref></contrib><contrib contrib-type="author"><name><surname>Aulchenko</surname><given-names>Yurii S.</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Polasek</surname><given-names>Ozren</given-names></name><xref ref-type="aff" rid="aff83"><sup>83</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hastie</surname><given-names>Nick</given-names></name><xref ref-type="aff" rid="aff84"><sup>84</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vitart</surname><given-names>Veronique</given-names></name><xref ref-type="aff" rid="aff84"><sup>84</sup></xref></contrib><contrib contrib-type="author"><name><surname>Helmer</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="aff85"><sup>85</sup></xref><xref ref-type="aff" rid="aff86"><sup>86</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jie Jin</given-names></name><xref ref-type="aff" rid="aff87"><sup>87</sup></xref><xref ref-type="aff" rid="aff88"><sup>88</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ruggiero</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="aff40"><sup>40</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bergmann</surname><given-names>Sven</given-names></name><xref ref-type="aff" rid="aff42"><sup>42</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kähönen</surname><given-names>Mika</given-names></name><xref ref-type="aff" rid="aff89"><sup>89</sup></xref></contrib><contrib contrib-type="author"><name><surname>Viikari</surname><given-names>Jorma</given-names></name><xref ref-type="aff" rid="aff90"><sup>90</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nikopensius</surname><given-names>Tiit</given-names></name><xref ref-type="aff" rid="aff45"><sup>45</sup></xref></contrib><contrib contrib-type="author"><name><surname>Province</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ketkar</surname><given-names>Shamika</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Colhoun</surname><given-names>Helen</given-names></name><xref ref-type="aff" rid="aff46"><sup>46</sup></xref></contrib><contrib contrib-type="author"><name><surname>Doney</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="aff91"><sup>91</sup></xref></contrib><contrib contrib-type="author"><name><surname>Robino</surname><given-names>Antonietta</given-names></name><xref ref-type="aff" rid="aff92"><sup>92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Giulianini</surname><given-names>Franco</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Krämer</surname><given-names>Bernhard K.</given-names></name><xref ref-type="aff" rid="aff93"><sup>93</sup></xref></contrib><contrib contrib-type="author"><name><surname>Portas</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ford</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="aff94"><sup>94</sup></xref></contrib><contrib contrib-type="author"><name><surname>Buckley</surname><given-names>Brendan M.</given-names></name><xref ref-type="aff" rid="aff95"><sup>95</sup></xref></contrib><contrib contrib-type="author"><name><surname>Adam</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Thun</surname><given-names>Gian-Andri</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Paulweber</surname><given-names>Bernhard</given-names></name><xref ref-type="aff" rid="aff96"><sup>96</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haun</surname><given-names>Margot</given-names></name><xref ref-type="aff" rid="aff97"><sup>97</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sala</surname><given-names>Cinzia</given-names></name><xref ref-type="aff" rid="aff53"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>Metzger</surname><given-names>Marie</given-names></name><xref ref-type="aff" rid="aff98"><sup>98</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="aff87"><sup>87</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ciullo</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="aff40"><sup>40</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Stuart K.</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vollenweider</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff99"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Raitakari</surname><given-names>Olli</given-names></name><xref ref-type="aff" rid="aff100"><sup>100</sup></xref></contrib><contrib contrib-type="author"><name><surname>Metspalu</surname><given-names>Andres</given-names></name><xref ref-type="aff" rid="aff44"><sup>44</sup></xref><xref ref-type="aff" rid="aff45"><sup>45</sup></xref></contrib><contrib contrib-type="author"><name><surname>Palmer</surname><given-names>Colin</given-names></name><xref ref-type="aff" rid="aff101"><sup>101</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gasparini</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="aff92"><sup>92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pirastu</surname><given-names>Mario</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jukema</surname><given-names>J. Wouter</given-names></name><xref ref-type="aff" rid="aff50"><sup>50</sup></xref><xref ref-type="aff" rid="aff102"><sup>102</sup></xref><xref ref-type="aff" rid="aff103"><sup>103</sup></xref><xref ref-type="aff" rid="aff104"><sup>104</sup></xref></contrib><contrib contrib-type="author"><name><surname>Probst-Hensch</surname><given-names>Nicole M.</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kronenberg</surname><given-names>Florian</given-names></name><xref ref-type="aff" rid="aff52"><sup>52</sup></xref></contrib><contrib contrib-type="author"><name><surname>Toniolo</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="aff53"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gudnason</surname><given-names>Vilmundur</given-names></name><xref ref-type="aff" rid="aff23"><sup>23</sup></xref><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shuldiner</surname><given-names>Alan R.</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff105"><sup>105</sup></xref></contrib><contrib contrib-type="author"><name><surname>Coresh</surname><given-names>Josef</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff106"><sup>106</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Reinhold</given-names></name><xref ref-type="aff" rid="aff57"><sup>57</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ferrucci</surname><given-names>Luigi</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Siscovick</surname><given-names>David S.</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M.</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Borecki</surname><given-names>Ingrid</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kardia</surname><given-names>Sharon L. R.</given-names></name><xref ref-type="aff" rid="aff107"><sup>107</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yongmei</given-names></name><xref ref-type="aff" rid="aff31"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Curhan</surname><given-names>Gary C.</given-names></name><xref ref-type="aff" rid="aff108"><sup>108</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rudan</surname><given-names>Igor</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gyllensten</surname><given-names>Ulf</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>James F.</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref></contrib><contrib contrib-type="author"><name><surname>Franke</surname><given-names>Andre</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pramstaller</surname><given-names>Peter P.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rettig</surname><given-names>Rainer</given-names></name><xref ref-type="aff" rid="aff109"><sup>109</sup></xref></contrib><contrib contrib-type="author"><name><surname>Prokopenko</surname><given-names>Inga</given-names></name><xref ref-type="aff" rid="aff81"><sup>81</sup></xref></contrib><contrib contrib-type="author"><name><surname>Witteman</surname><given-names>Jacqueline C. M.</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="aff84"><sup>84</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ridker</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref><xref ref-type="aff" rid="aff110"><sup>110</sup></xref></contrib><contrib contrib-type="author"><name><surname>Parsa</surname><given-names>Afshin</given-names></name><xref ref-type="aff" rid="aff111"><sup>111</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bochud</surname><given-names>Murielle</given-names></name><xref ref-type="aff" rid="aff112"><sup>112</sup></xref></contrib><contrib contrib-type="author"><name><surname>Heid</surname><given-names>Iris M.</given-names></name><xref ref-type="aff" rid="aff113"><sup>113</sup></xref><xref ref-type="aff" rid="aff114"><sup>114</sup></xref></contrib><contrib contrib-type="author"><name><surname>Goessling</surname><given-names>Wolfram</given-names></name><xref ref-type="aff" rid="aff115"><sup>115</sup></xref><xref ref-type="aff" rid="aff116"><sup>116</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chasman</surname><given-names>Daniel I.</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref><xref ref-type="aff" rid="aff110"><sup>110</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kao</surname><given-names>W. H. Linda</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff106"><sup>106</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Caroline S.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref><xref ref-type="aff" rid="aff117"><sup>117</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>¶</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Renal Division, Freiburg University Clinic, Freiburg, Germany</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany</addr-line></aff><aff id="aff7"><label>7</label><addr-line>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America</addr-line></aff><aff id="aff8"><label>8</label><addr-line>Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany</addr-line></aff><aff id="aff9"><label>9</label><addr-line>Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany</addr-line></aff><aff id="aff10"><label>10</label><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff11"><label>11</label><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff12"><label>12</label><addr-line>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></aff><aff id="aff13"><label>13</label><addr-line>Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany</addr-line></aff><aff id="aff14"><label>14</label><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></aff><aff id="aff15"><label>15</label><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff16"><label>16</label><addr-line>Renal Division, Freiburg University Clinic, Freiburg, Germany</addr-line></aff><aff id="aff17"><label>17</label><addr-line>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America</addr-line></aff><aff id="aff18"><label>18</label><addr-line>Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff19"><label>19</label><addr-line>Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff20"><label>20</label><addr-line>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff21"><label>21</label><addr-line>Centre for Medical Systems Biology, Leiden, The Netherlands</addr-line></aff><aff id="aff22"><label>22</label><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff23"><label>23</label><addr-line>Icelandic Heart Association, Research Institute, Kopavogur, Iceland</addr-line></aff><aff id="aff24"><label>24</label><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></aff><aff id="aff25"><label>25</label><addr-line>Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff26"><label>26</label><addr-line>Department of Epidemiology and Biostatistics and Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam, The Netherlands</addr-line></aff><aff id="aff27"><label>27</label><addr-line>Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff28"><label>28</label><addr-line>University of Washington, Seattle, Washington, United States of America</addr-line></aff><aff id="aff29"><label>29</label><addr-line>Department of Developmental Biology, Stanford University, Stanford, California, United States of America</addr-line></aff><aff id="aff30"><label>30</label><addr-line>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff31"><label>31</label><addr-line>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></aff><aff id="aff32"><label>32</label><addr-line>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff33"><label>33</label><addr-line>Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</addr-line></aff><aff id="aff34"><label>34</label><addr-line>Department of Medicine, University of Leipzig, Leipzig, Germany</addr-line></aff><aff id="aff35"><label>35</label><addr-line>IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany</addr-line></aff><aff id="aff36"><label>36</label><addr-line>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff37"><label>37</label><addr-line>Inserm UMR744, Institut Pasteur, Lille, France</addr-line></aff><aff id="aff38"><label>38</label><addr-line>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia</addr-line></aff><aff id="aff39"><label>39</label><addr-line>Centre for Information-based Medicine, Hunter Medical Research Institute, Newcastle, Australia</addr-line></aff><aff id="aff40"><label>40</label><addr-line>Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy</addr-line></aff><aff id="aff41"><label>41</label><addr-line>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</addr-line></aff><aff id="aff42"><label>42</label><addr-line>Swiss Institute of Bioinformatics, Lausanne, Switzerland</addr-line></aff><aff id="aff43"><label>43</label><addr-line>Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Centre for Laboratory Medicine Tampere Finn-Medi 2, Tampere, Finland</addr-line></aff><aff id="aff44"><label>44</label><addr-line>Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia</addr-line></aff><aff id="aff45"><label>45</label><addr-line>Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</addr-line></aff><aff id="aff46"><label>46</label><addr-line>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom</addr-line></aff><aff id="aff47"><label>47</label><addr-line>Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy</addr-line></aff><aff id="aff48"><label>48</label><addr-line>Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff49"><label>49</label><addr-line>Institute of Population Genetics – CNR, Sassari, Italy</addr-line></aff><aff id="aff50"><label>50</label><addr-line>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</addr-line></aff><aff id="aff51"><label>51</label><addr-line>Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></aff><aff id="aff52"><label>52</label><addr-line>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria</addr-line></aff><aff id="aff53"><label>53</label><addr-line>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy</addr-line></aff><aff id="aff54"><label>54</label><addr-line>Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America</addr-line></aff><aff id="aff55"><label>55</label><addr-line>Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America</addr-line></aff><aff id="aff56"><label>56</label><addr-line>Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Graz, Austria</addr-line></aff><aff id="aff57"><label>57</label><addr-line>Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria</addr-line></aff><aff id="aff58"><label>58</label><addr-line>Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff59"><label>59</label><addr-line>Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff60"><label>60</label><addr-line>Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></aff><aff id="aff61"><label>61</label><addr-line>Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></aff><aff id="aff62"><label>62</label><addr-line>Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America</addr-line></aff><aff id="aff63"><label>63</label><addr-line>Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany</addr-line></aff><aff id="aff64"><label>64</label><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></aff><aff id="aff65"><label>65</label><addr-line>Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</addr-line></aff><aff id="aff66"><label>66</label><addr-line>Klinikum Grosshadern, Neuherberg, Germany</addr-line></aff><aff id="aff67"><label>67</label><addr-line>Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</addr-line></aff><aff id="aff68"><label>68</label><addr-line>Department of Genetics, Stanford University, Stanford, California, United States of America</addr-line></aff><aff id="aff69"><label>69</label><addr-line>Department of Medicine, University of Chicago, Chicago, Illinois, United States of America</addr-line></aff><aff id="aff70"><label>70</label><addr-line>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom</addr-line></aff><aff id="aff71"><label>71</label><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></aff><aff id="aff72"><label>72</label><addr-line>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany</addr-line></aff><aff id="aff73"><label>73</label><addr-line>popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany</addr-line></aff><aff id="aff74"><label>74</label><addr-line>Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany</addr-line></aff><aff id="aff75"><label>75</label><addr-line>Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany</addr-line></aff><aff id="aff76"><label>76</label><addr-line>Institute of Pharmacology, University of Greifswald, Greifswald, Germany</addr-line></aff><aff id="aff77"><label>77</label><addr-line>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</addr-line></aff><aff id="aff78"><label>78</label><addr-line>Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany</addr-line></aff><aff id="aff79"><label>79</label><addr-line>Institute for Community Medicine, University of Greifswald, Greifswald, Germany</addr-line></aff><aff id="aff80"><label>80</label><addr-line>Department of Medicine, University of Leipzig, Leipzig, Germany</addr-line></aff><aff id="aff81"><label>81</label><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom</addr-line></aff><aff id="aff82"><label>82</label><addr-line>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line></aff><aff id="aff83"><label>83</label><addr-line>Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia</addr-line></aff><aff id="aff84"><label>84</label><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom</addr-line></aff><aff id="aff85"><label>85</label><addr-line>INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED, Bordeaux, France</addr-line></aff><aff id="aff86"><label>86</label><addr-line>Université Bordeaux 2 Victor Segalen, Bordeaux, France</addr-line></aff><aff id="aff87"><label>87</label><addr-line>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia</addr-line></aff><aff id="aff88"><label>88</label><addr-line>Centre for Eye Research Australia (CERA), University of Melbourne, Melbourne, Australia</addr-line></aff><aff id="aff89"><label>89</label><addr-line>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland</addr-line></aff><aff id="aff90"><label>90</label><addr-line>Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland</addr-line></aff><aff id="aff91"><label>91</label><addr-line>NHS Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom</addr-line></aff><aff id="aff92"><label>92</label><addr-line>Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy</addr-line></aff><aff id="aff93"><label>93</label><addr-line>University Medical Centre Mannheim, 5th Department of Medicine, Mannheim, Germany</addr-line></aff><aff id="aff94"><label>94</label><addr-line>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom</addr-line></aff><aff id="aff95"><label>95</label><addr-line>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</addr-line></aff><aff id="aff96"><label>96</label><addr-line>First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria</addr-line></aff><aff id="aff97"><label>97</label><addr-line>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria</addr-line></aff><aff id="aff98"><label>98</label><addr-line>Inserm UMRS 1018, CESP Team 10, Université Paris Sud, Villejuif, France</addr-line></aff><aff id="aff99"><label>99</label><addr-line>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</addr-line></aff><aff id="aff100"><label>100</label><addr-line>Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, Turku University Hospital, University of Turku, Turku, Finland</addr-line></aff><aff id="aff101"><label>101</label><addr-line>Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom</addr-line></aff><aff id="aff102"><label>102</label><addr-line>Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands</addr-line></aff><aff id="aff103"><label>103</label><addr-line>Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands</addr-line></aff><aff id="aff104"><label>104</label><addr-line>Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</addr-line></aff><aff id="aff105"><label>105</label><addr-line>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff106"><label>106</label><addr-line>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff107"><label>107</label><addr-line>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America</addr-line></aff><aff id="aff108"><label>108</label><addr-line>Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff109"><label>109</label><addr-line>Institute of Physiology, University of Greifswald, Greifswald, Germany</addr-line></aff><aff id="aff110"><label>110</label><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff111"><label>111</label><addr-line>Division of Nephrology, University of Maryland Medical School, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff112"><label>112</label><addr-line>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland</addr-line></aff><aff id="aff113"><label>113</label><addr-line>Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany</addr-line></aff><aff id="aff114"><label>114</label><addr-line>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></aff><aff id="aff115"><label>115</label><addr-line>Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff116"><label>116</label><addr-line>Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America</addr-line></aff><aff id="aff117"><label>117</label><addr-line>Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Gibson</surname><given-names>Greg</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1">Georgia Institute of Technology, United States of America</aff><author-notes><corresp id="cor1">* E-mail: <email>foxca@nhlbi.nih.gov</email> (CSF); <email>wkao@jhsph.edu</email> (WHL Kao)</corresp><fn fn-type="con"><p>Study design: V Gudnason, TB Harris, LJ Launer, G Eiriksdottir, A Parsa, A Köttgen, WHL Kao, R Schmidt, L Ferrucci, DS Siscovick, BA Oostra, CM van Duijn, I Borecki, CS Fox, FB Hu, CA Böger, M Gorski, T Illig, A Döring, HE Wichmann, IM Heid, I Rudan, PP Pramstaller, GC Curhan, U Gyllensten, JF Wilson, SH Wild, AF Wright, H Campbell, A Hofman, AG Uitterlinden, JCM Witteman, R Biffar, K Endlich, R Rettig, S Stracke, H Völzke, P Kovacs, A Tönjes, O Polasek, N Hastie, C Hayward, V Vitart, DI Chasman, P Ridker, C Helmer, A Metspalu, JJ Wang, P Mitchell, M Province, X Gao, M Ciullo, P Vollenweider, M Pirastu, B Paulweber, D Toniolo, T Lehtimäki, O Raitakari, M Kähönen, J Viikari, P Gasparini, H Colhoun, A Doney, C Palmer, H Deshmukh, S Trompet, I Ford, BM Buckley, JW Jukema, NM Probst-Hensch. Study management: V Gudnason, TB Harris, LJ Launer, G Eiriksdottir, A Parsa, WHL Kao, R Schmidt, H Schmidt, M Cavalieri, L Ferrucci, DS Siscovick, A Isaacs, BA Oostra, CM van Duijn, I Borecki, CS Fox, J Ding, Y Liu, MC Cornelis, FB Hu, W Koenig, T Illig, A Döring, HE Wichmann, I Rudan, I Kolcic, T Zemunik, M Boban, C Pattaro, PP Pramstaller, GC Curhan, A Johansson, G Zaboli, U Gyllensten, JF Wilson, SH Wild, U Nöthlings, A Hofman, AG Uitterlinden, JCM Witteman, R Biffar, K Endlich, R Rettig, U Völker, H Völkze, M Stumvoll, A Tönjes, O Polasek, N Hastie, C Hayward, V Vitart, DI Chasman, P Ridker, C Helmer, A Metspalu, JJ Wang, P Mitchell, M Province, X Gao, M Ciullo, M Bochud, P Vollenweider, M Pirastu, B Kollerits, M Haun, B Paulweber, F Kronenberg, D Toniolo, T Lehtimäki, O Raitakari, M Kähönen, J Viikari, P Gasparini, F Giulianini, H Colhoun, A Doney, C Palmer, H Deshmukh, S Trompet, I Ford, BM Buckley, JW Jukema, BK Krämer, NM Probst-Hensch, M Imboden. Subject recruitment: G Eiriksdottir, AR Shuldiner, BD Mitchell, J Coresh, R Schmidt, M Cavalieri, DS Siscovick, BA Oostra, CM van Duijn, TB Harris, T Illig, A Döring, HE Wichmann, I Rudan, I Kolcic, PP Pramstaller, A Johansson, JF Wilson, SH Wild, A Hofman, AG Uitterlinden, JCM Witteman, R Biffar, R Rettig, S Stracke, H Völkze, A Tönjes, O Polasek, C Helmer, P Mitchell, M Ciullo, P Vollenweider, M Pirastu, B Paulweber, D Toniolo, O Raitakari, M Kähönen, J Viikari, S Ulivi, A Robino, P Ridker, H Colhoun, A Doney, C Palmer, I Ford, BM Buckley, JW Jukema, NM Probst-Hensch. Genotyping: AR Shuldiner, BD Mitchell, E Boerwinkle, H Schmidt, A Isaacs, A Demirkan, BA Oostra, CM van Duijn, M de Andrade, EJ Atkinson, ST Turner, SLR Kardia, Y Liu, CA Böger, M Gorski, T Illig, HE Wichmann, IM Heid, JF Wilson, H Campbell, A Franke, AG Uitterlinden, F Rivadeneira, F Ernst, G Homuth, HK Kroemer, M Nauck, U Völker, M Stumvoll, O Polasek, C Hayward, DI Chasman, T Esko, M Haun, F Kronenberg, T Lehtimäki, F Giulianini, S Trompet, JW Jukema. Statistical methods and analysis: T Aspelund, AV Smith, A Parsa, JR O'Connell, A Köttgen, WHL Kao, A Tin, C Hundertmark, M Struchalin, T Tanaka, G Li, A Isaacs, A Demirkan, M Feitosa, CS Fox, MH Chen, MC Foster, SJ Hwang, Q Yang, K Lohman, JS Andrews, Y Liu, MC Cornelis, CA Böger, M Gorski, IM Heid, C Pattaro, D Taliun, C Fuchsberger, C Minelli, A Johansson, W Igl, D Ellinghaus, A Franke, A Dehghan, F Rivadeneira, YS Aulchenko, A Teumer, I Prokopenko, R Mägi, C Hayward, V Vitart, DI Chasman, T Esko, EG Holliday, X Gao, S Ketkar, D Ruggiero, R Sorice, Z Kutalik, S Bergmann, F Murgia, L Portas, B Kollerits, F Kronenberg, G Pistis, S Ulivi, A Robino, AY Chu, H Colhoun, A Doney, C Palmer, H Deshmukh, I Ford, NM Probst-Hensch, M Adam, GA Thun, M Olden, M Li, N Glazer, HJ Gierman, V Chouraki, HE Wheeler, G Jacobs, T Nikopensius, M Metzger. Bioinformatics: AV Smith, JR O'Connell, C Hundertmark, M Struchalin, G Li, MH Chen, Q Yang, K Lohman, JS Andrews, Y Liu, MC Cornelis, CA Böger, M Gorski, IM Heid, C Pattaro, D Taliun, C Fuchsberger, A Johansson, W Igl, D Ellinghaus, A Dehghan, F Rivadeneira, YS Aulchenko, HK Kroemer, A Teumer, I Prokopenko, R Mägi, DI Chasman, T Esko, D Ruggiero, R Sorice, S Bergmann, F Murgia, L Portas, G Pistis, C Sala, T Lehtimäki, O Raitakari, S Ulivi, F Giulianini, S Trompet, I Ford, M Imboden, C-T Liu, AD Johnson, SK Kim. Zebrafish studies: M Garnaas, W Goessling. Interpretation of results: V Gudnason, TB Harris, LJ Launer, AV Smith, A Parsa, A Köttgen, WHL Kao, A Tin, DS Siscovick, G Li, M Rao, A Isaacs, MH Chen, MC Foster, SJ Hwang, Q Yang, J Ding, K Lohman, Y Liu, CA Böger, M Gorski, IM Heid, I Rudan, T Zemunik, M Boban, C Pattaro, D Taliun, A Johansson, W Igl, G Zaboli, U Gyllensten, JF Wilson, SH Wild, R Biffar, K Endlich, HK Kroemer, M Nauck, R Rettig, S Stracke, A Teumer, U Völker, H Völkze, O Polasek, N Hastie, C Hayward, V Vitart, DI Chasman, BI Freedman, T Esko, A Metspalu, EG Holliday, I Borecki, M Province, X Gao, M Ciullo, M Bochud, B Kollerits, M Haun, B Paulweber, F Kronenberg, D Toniolo, G Pistis, C Sala, AY Chu, S Trompet, JW Jukema, M Garnaas, W Goessling, CS Fox. Wrote the manuscript: C Pattaro, A Köttgen, A Teumer, M Garnaas, CA Böger, C Fuchsberger, A Tin, CM O'Seaghdha, A Parsa, M Bochud, IM Heid, W Goessling, DI Chasman, WHL Kao, CS Fox.</p></fn><fn id="fn1" fn-type="other"><p>¶ These authors were joint senior authors on this work.</p></fn></author-notes><pub-date pub-type="collection"><month>3</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>29</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="ecorrected"><day>02
</day><month>4</month><year>2012</year></pub-date><volume>8</volume><issue>3</issue><elocation-id>e1002584</elocation-id><history><date date-type="received"><day>1</day><month>10</month><year>2011</year></date><date date-type="accepted"><day>22</day><month>1</month><year>2012</year></date></history><permissions><copyright-statement>Pattaro et al.</copyright-statement><copyright-year>2012</copyright-year><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><abstract><p>Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near <italic>MPPED2</italic>, <italic>DDX1</italic>, <italic>SLC47A1</italic>, <italic>CDK12</italic>, <italic>CASP9</italic>, and <italic>INO80</italic>. Morpholino knockdown of <italic>mpped2</italic> and <italic>casp9</italic> in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.</p></abstract><abstract abstract-type="summary"><title>Author Summary</title><p>Chronic kidney disease (CKD) is an important public health problem with a hereditary component. We performed a new genome-wide association study in up to 130,600 European ancestry individuals to identify genes that may influence kidney function, specifically genes that may influence kidney function differently depending on sex, age, hypertension, and diabetes status of individuals. We uncovered 6 new loci associated with estimated glomerular filtration rate (eGFR), the primary measure of renal function, in or near <italic>MPPED2</italic>, <italic>DDX1</italic>, <italic>SLC47A1</italic>, <italic>CDK12</italic>, <italic>CASP9</italic>, and <italic>INO80</italic>. <italic>CDK12</italic> effect was stronger in younger and absent in older individuals. <italic>MPPED2</italic>, <italic>DDX1</italic>, <italic>SLC47A1</italic>, and <italic>CDK12</italic> loci were associated with eGFR in African ancestry samples as well, highlighting the cross-ethnicity validity of our findings. Using the zebrafish model, we performed morpholino knockdown of <italic>mpped2</italic> and <italic>casp9</italic> in zebrafish embryos and revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. These results further our understanding of the pathogenesis of CKD and provide insights into potential novel mechanisms of disease.</p></abstract><counts><page-count count="15"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |