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Serveur d'exploration sur les relations entre la France et l'Australie

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Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics

Identifieur interne : 002720 ( Pmc/Curation ); précédent : 002719; suivant : 002721

Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics

Auteurs : Montserrat Garcia-Closas [États-Unis] ; Per Hall [Suède] ; Heli Nevanlinna [Finlande] ; Karen Pooley [Royaume-Uni] ; Jonathan Morrison [Royaume-Uni] ; Douglas A. Richesson [États-Unis] ; Stig E. Bojesen [Danemark] ; B Rge G. Nordestgaard [Danemark] ; Christen K. Axelsson [Danemark] ; Jose I. Arias [Espagne] ; Roger L. Milne [Espagne] ; Gloria Ribas [Espagne] ; Anna González-Neira [Espagne] ; Javier Benítez [Espagne] ; Pilar Zamora [Espagne] ; Hiltrud Brauch [Allemagne] ; Christina Justenhoven [Allemagne] ; Ute Hamann [Allemagne] ; Yon-Dschun Ko [Allemagne] ; Thomas Bruening [Allemagne] ; Susanne Haas [Allemagne] ; Thilo Dörk [Allemagne] ; Peter Schürmann [Allemagne] ; Peter Hillemanns [Allemagne] ; Natalia Bogdanova [Allemagne] ; Michael Bremer [Allemagne] ; Johann Hinrich Karstens [Allemagne] ; Rainer Fagerholm [Finlande] ; Kirsimari Aaltonen [Finlande] ; Kristiina Aittom Ki [Finlande] ; Karl Von Smitten [Finlande] ; Carl Blomqvist [Finlande] ; Arto Mannermaa [Finlande] ; Matti Uusitupa [Finlande] ; Matti Eskelinen [Finlande] ; Maria Tengström [Finlande] ; Veli-Matti Kosma [Finlande] ; Vesa Kataja [Finlande] ; Georgia Chenevix-Trench [Australie] ; Amanda B. Spurdle [Australie] ; Jonathan Beesley [Australie] ; Xiaoqing Chen [Australie] ; Peter Devilee [Pays-Bas] ; Christi J. Van Asperen [Pays-Bas] ; Catharina E. Jacobi [Pays-Bas] ; Rob A. E. M. Tollenaar [Pays-Bas] ; Petra E. A. Huijts [Pays-Bas] ; Jan G. M. Klijn [Pays-Bas] ; Jenny Chang-Claude [Allemagne] ; Silke Kropp [Allemagne] ; Tracy Slanger [Allemagne] ; Dieter Flesch-Janys [Allemagne] ; Elke Mutschelknauss [Allemagne] ; Ramona Salazar [Allemagne] ; Shan Wang-Gohrke [Allemagne] ; Fergus Couch [États-Unis] ; Ellen L. Goode [États-Unis] ; Janet E. Olson [États-Unis] ; Celine Vachon [États-Unis] ; Zachary S. Fredericksen [États-Unis] ; Graham G. Giles [Australie] ; Laura Baglietto [Australie] ; Gianluca Severi [Australie] ; John L. Hopper [Australie] ; Dallas R. English [Australie] ; Melissa C. Southey [Australie] ; Christopher A. Haiman [États-Unis] ; Brian E. Henderson [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Loic Le Marchand [États-Unis] ; Daniel O. Stram [États-Unis] ; David J. Hunter [États-Unis] ; Susan E. Hankinson [États-Unis] ; David G. Cox [États-Unis] ; Rulla Tamimi [États-Unis] ; Peter Kraft [États-Unis] ; Mark E. Sherman [États-Unis] ; Stephen J. Chanock [États-Unis] ; Jolanta Lissowska [Pologne] ; Louise A. Brinton [États-Unis] ; Beata Peplonska [Pologne] ; Jan G. M. Klijn [Pays-Bas] ; Maartje J. Hooning [Pays-Bas] ; Han Meijers-Heijboer [Pays-Bas] ; J. Margriet Collee [Pays-Bas] ; Ans Van Den Ouweland [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; Jianjun Liu [Singapour] ; Low Yen Lin [Singapour] ; Li Yuqing [Singapour] ; Keith Humphreys [Suède] ; Kamila Czene [Suède] ; Angela Cox [Royaume-Uni] ; Sabapathy P. Balasubramanian [Royaume-Uni] ; Simon S. Cross [Royaume-Uni] ; Malcolm W. R. Reed [Royaume-Uni] ; Fiona Blows [Royaume-Uni] ; Kristy Driver [Royaume-Uni] ; Alison Dunning [Royaume-Uni] ; Jonathan Tyrer [Royaume-Uni] ; Bruce A. J. Ponder [Royaume-Uni] ; Suleeporn Sangrajrang [Thaïlande] ; Paul Brennan [France] ; James Mckay [France] ; Fabrice Odefrey [France] ; Valerie Gabrieau [France] ; Alice Sigurdson [États-Unis] ; Michele Doody [États-Unis] ; Jeffrey P. Struewing ; Bruce Alexander [États-Unis] ; Douglas F. Easton [Royaume-Uni] ; Paul D. Pharoah [Royaume-Uni]

Source :

RBID : PMC:2291027

Abstract

A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs and breast cancer risk varied by clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls from 20 studies. We also evaluated their influence on overall survival in 13,527 cases from 13 studies. All participants were of European or Asian origin. rs2981582 in FGFR2 was more strongly related to ER-positive (per-allele OR (95%CI) = 1.31 (1.27–1.36)) than ER-negative (1.08 (1.03–1.14)) disease (P for heterogeneity = 10−13). This SNP was also more strongly related to PR-positive, low grade and node positive tumors (P = 10−5, 10−8, 0.013, respectively). The association for rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10−4, respectively). The differences in the associations between SNPs in FGFR2 and 8q24 and risk by ER and grade remained significant after permutation adjustment for multiple comparisons and after adjustment for other tumor characteristics. Three SNPs (rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09–1.21)). rs13281615 in 8q24 was associated with an improvement in survival after diagnosis (per-allele HR = 0.90 (0.83–0.97). The association was attenuated and non-significant after adjusting for known prognostic factors. Our findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct. Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment.


Url:
DOI: 10.1371/journal.pgen.1000054
PubMed: 18437204
PubMed Central: 2291027

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Jeffrey P. Struewing
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<name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
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<name sortKey="Axelsson, Christen K" sort="Axelsson, Christen K" uniqKey="Axelsson C" first="Christen K." last="Axelsson">Christen K. Axelsson</name>
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<addr-line>Monte Naranco Hospital, Oviedo, Spain</addr-line>
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<name sortKey="Ribas, Gloria" sort="Ribas, Gloria" uniqKey="Ribas G" first="Gloria" last="Ribas">Gloria Ribas</name>
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<name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
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<addr-line>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany</addr-line>
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<wicri:regionArea>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen</wicri:regionArea>
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<name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
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<addr-line>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany</addr-line>
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<country xml:lang="fr">Allemagne</country>
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<name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
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<addr-line>Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Deutsches Krebsforschungszentrum Heidelberg, Heidelberg</wicri:regionArea>
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<name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name>
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<addr-line>Evangelische Kliniken Bonn gGmhH Johanniter Krankenhaus, Bonn, Germany</addr-line>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Evangelische Kliniken Bonn gGmhH Johanniter Krankenhaus, Bonn</wicri:regionArea>
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<name sortKey="Bruening, Thomas" sort="Bruening, Thomas" uniqKey="Bruening T" first="Thomas" last="Bruening">Thomas Bruening</name>
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<addr-line>Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr University Bochum, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr University Bochum</wicri:regionArea>
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<name sortKey="Haas, Susanne" sort="Haas, Susanne" uniqKey="Haas S" first="Susanne" last="Haas">Susanne Haas</name>
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<addr-line>Institute für Pathology, University Bonn, Bonn, Germany</addr-line>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute für Pathology, University Bonn, Bonn</wicri:regionArea>
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<name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
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<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover</wicri:regionArea>
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<name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name>
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<nlm:aff id="aff16">
<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover</wicri:regionArea>
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<nlm:aff id="aff16">
<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover</wicri:regionArea>
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<name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea>
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<name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea>
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</author>
<author>
<name sortKey="Karstens, Johann Hinrich" sort="Karstens, Johann Hinrich" uniqKey="Karstens J" first="Johann Hinrich" last="Karstens">Johann Hinrich Karstens</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea>
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<name sortKey="Fagerholm, Rainer" sort="Fagerholm, Rainer" uniqKey="Fagerholm R" first="Rainer" last="Fagerholm">Rainer Fagerholm</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<addr-line>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
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<name sortKey="Aaltonen, Kirsimari" sort="Aaltonen, Kirsimari" uniqKey="Aaltonen K" first="Kirsimari" last="Aaltonen">Kirsimari Aaltonen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<addr-line>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<addr-line>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Von Smitten, Karl" sort="Von Smitten, Karl" uniqKey="Von Smitten K" first="Karl" last="Von Smitten">Karl Von Smitten</name>
<affiliation wicri:level="1">
<nlm:aff id="aff20">
<addr-line>Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Surgery, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<addr-line>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<addr-line>Department of Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<addr-line>Department of Public Health and Clinical Nutrition, Biocenter Kuopio, University of Kuopio, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Public Health and Clinical Nutrition, Biocenter Kuopio, University of Kuopio, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eskelinen, Matti" sort="Eskelinen, Matti" uniqKey="Eskelinen M" first="Matti" last="Eskelinen">Matti Eskelinen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<addr-line>Department of Surgery, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Surgery, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tengstrom, Maria" sort="Tengstrom, Maria" uniqKey="Tengstrom M" first="Maria" last="Tengström">Maria Tengström</name>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<addr-line>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<addr-line>Department of Oncology, Vaasa Central Hospital, Vaasa, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Vaasa Central Hospital, Vaasa</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<addr-line>Department of Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<addr-line>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<addr-line>Department of Oncology, Vaasa Central Hospital, Vaasa, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Vaasa Central Hospital, Vaasa</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<addr-line>Departments of Human Genetics and Pathology, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Human Genetics and Pathology, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<addr-line>Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jacobi, Catharina E" sort="Jacobi, Catharina E" uniqKey="Jacobi C" first="Catharina E." last="Jacobi">Catharina E. Jacobi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<addr-line>Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Decision Making, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<addr-line>Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Huijts, Petra E A" sort="Huijts, Petra E A" uniqKey="Huijts P" first="Petra E. A." last="Huijts">Petra E. A. Huijts</name>
<affiliation wicri:level="1">
<nlm:aff id="aff33">
<addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Klijn, Jan G M" sort="Klijn, Jan G M" uniqKey="Klijn J" first="Jan G. M." last="Klijn">Jan G. M. Klijn</name>
<affiliation wicri:level="1">
<nlm:aff id="aff33">
<addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<addr-line>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kropp, Silke" sort="Kropp, Silke" uniqKey="Kropp S" first="Silke" last="Kropp">Silke Kropp</name>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<addr-line>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Slanger, Tracy" sort="Slanger, Tracy" uniqKey="Slanger T" first="Tracy" last="Slanger">Tracy Slanger</name>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<addr-line>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<addr-line>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mutschelknauss, Elke" sort="Mutschelknauss, Elke" uniqKey="Mutschelknauss E" first="Elke" last="Mutschelknauss">Elke Mutschelknauss</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<addr-line>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Salazar, Ramona" sort="Salazar, Ramona" uniqKey="Salazar R" first="Ramona" last="Salazar">Ramona Salazar</name>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<addr-line>Bioglobe GmbH, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bioglobe GmbH, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name>
<affiliation wicri:level="1">
<nlm:aff id="aff37">
<addr-line>Molecular Biology Laboratory, Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Biology Laboratory, Department of Obstetrics and Gynecology, University of Ulm, Ulm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Couch, Fergus" sort="Couch, Fergus" uniqKey="Couch F" first="Fergus" last="Couch">Fergus Couch</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S." last="Fredericksen">Zachary S. Fredericksen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<addr-line>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<addr-line>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<addr-line>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1">
<nlm:aff id="aff40">
<addr-line>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name>
<affiliation wicri:level="1">
<nlm:aff id="aff40">
<addr-line>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="1">
<nlm:aff id="aff41">
<addr-line>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff42">
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff42">
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name>
<affiliation wicri:level="1">
<nlm:aff id="aff43">
<addr-line>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="1">
<nlm:aff id="aff43">
<addr-line>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff44">
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation wicri:level="1">
<nlm:aff id="aff45">
<addr-line>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
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</author>
<author>
<name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
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<affiliation wicri:level="1">
<nlm:aff id="aff47">
<addr-line>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
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</author>
<author>
<name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
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</author>
<author>
<name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="1">
<nlm:aff id="aff47">
<addr-line>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
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</author>
<author>
<name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name>
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<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
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<author>
<name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
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<addr-line>Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland</wicri:regionArea>
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<author>
<name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
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<nlm:aff id="aff49">
<addr-line>Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw</wicri:regionArea>
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</author>
<author>
<name sortKey="Brinton, Louise A" sort="Brinton, Louise A" uniqKey="Brinton L" first="Louise A." last="Brinton">Louise A. Brinton</name>
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<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
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</author>
<author>
<name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name>
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<nlm:aff id="aff50">
<addr-line>Nofer Institute of Occupational Medicine, Lodz, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Nofer Institute of Occupational Medicine, Lodz</wicri:regionArea>
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<author>
<name sortKey="Klijn, Jan G M" sort="Klijn, Jan G M" uniqKey="Klijn J" first="Jan G. M." last="Klijn">Jan G. M. Klijn</name>
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<nlm:aff id="aff51">
<addr-line>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam</wicri:regionArea>
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</author>
<author>
<name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
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<nlm:aff id="aff51">
<addr-line>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam</wicri:regionArea>
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<author>
<name sortKey="Meijers Heijboer, Han" sort="Meijers Heijboer, Han" uniqKey="Meijers Heijboer H" first="Han" last="Meijers-Heijboer">Han Meijers-Heijboer</name>
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<nlm:aff id="aff52">
<addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collee">J. Margriet Collee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Den Ouweland, Ans" sort="Van Den Ouweland, Ans" uniqKey="Van Den Ouweland A" first="Ans" last="Van Den Ouweland">Ans Van Den Ouweland</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
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<nlm:aff id="aff53">
<addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<addr-line>Human Genetics, Genome Institute of Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lin, Low Yen" sort="Lin, Low Yen" uniqKey="Lin L" first="Low Yen" last="Lin">Low Yen Lin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<addr-line>Human Genetics, Genome Institute of Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yuqing, Li" sort="Yuqing, Li" uniqKey="Yuqing L" first="Li" last="Yuqing">Li Yuqing</name>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<addr-line>Human Genetics, Genome Institute of Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation wicri:level="1">
<nlm:aff id="aff55">
<addr-line>Institute for Cancer Studies, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Cancer Studies, Sheffield University Medical School, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Balasubramanian, Sabapathy P" sort="Balasubramanian, Sabapathy P" uniqKey="Balasubramanian S" first="Sabapathy P." last="Balasubramanian">Sabapathy P. Balasubramanian</name>
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<nlm:aff id="aff56">
<addr-line>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield</wicri:regionArea>
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<author>
<name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
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<nlm:aff id="aff57">
<addr-line>Academic Unit of Pathology, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Pathology, Sheffield University Medical School, Sheffield</wicri:regionArea>
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<author>
<name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name>
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<nlm:aff id="aff56">
<addr-line>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield</wicri:regionArea>
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</author>
<author>
<name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name>
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<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<addr-line>Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK, Cambridge Research Institute, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">
<addr-line>Molecular Epidemiology Unit, National Cancer Institute, Ratchathewi, Bangkok, Thailand</addr-line>
</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Molecular Epidemiology Unit, National Cancer Institute, Ratchathewi, Bangkok</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name>
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<nlm:aff id="aff60">
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gabrieau, Valerie" sort="Gabrieau, Valerie" uniqKey="Gabrieau V" first="Valerie" last="Gabrieau">Valerie Gabrieau</name>
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<nlm:aff id="aff60">
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sigurdson, Alice" sort="Sigurdson, Alice" uniqKey="Sigurdson A" first="Alice" last="Sigurdson">Alice Sigurdson</name>
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<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Doody, Michele" sort="Doody, Michele" uniqKey="Doody M" first="Michele" last="Doody">Michele Doody</name>
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<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
</affiliation>
</author>
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<name sortKey="Struewing, Jeffrey P" sort="Struewing, Jeffrey P" uniqKey="Struewing J" first="Jeffrey P." last="Struewing">Jeffrey P. Struewing</name>
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<addr-line>Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, United Stated of America</addr-line>
</nlm:aff>
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<name sortKey="Alexander, Bruce" sort="Alexander, Bruce" uniqKey="Alexander B" first="Bruce" last="Alexander">Bruce Alexander</name>
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<nlm:aff id="aff62">
<addr-line>Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
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<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
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<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name>
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<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
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<title xml:lang="en" level="a" type="main">Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics</title>
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<name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
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<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
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<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
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<name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
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<nlm:aff id="aff2">
<addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea>
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<name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
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<addr-line>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
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<wicri:regionArea>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
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<name sortKey="Pooley, Karen" sort="Pooley, Karen" uniqKey="Pooley K" first="Karen" last="Pooley">Karen Pooley</name>
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<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
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<name sortKey="Morrison, Jonathan" sort="Morrison, Jonathan" uniqKey="Morrison J" first="Jonathan" last="Morrison">Jonathan Morrison</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Richesson, Douglas A" sort="Richesson, Douglas A" uniqKey="Richesson D" first="Douglas A." last="Richesson">Douglas A. Richesson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<addr-line>Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<addr-line>Department of Bispebjerg University Hospitals, University of Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Bispebjerg University Hospitals, University of Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<addr-line>Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Axelsson, Christen K" sort="Axelsson, Christen K" uniqKey="Axelsson C" first="Christen K." last="Axelsson">Christen K. Axelsson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<addr-line>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Arias, Jose I" sort="Arias, Jose I" uniqKey="Arias J" first="Jose I." last="Arias">Jose I. Arias</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<addr-line>Spanish National Cancer Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Centre, Madrid</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<addr-line>Monte Naranco Hospital, Oviedo, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Monte Naranco Hospital, Oviedo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<addr-line>Spanish National Cancer Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Centre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ribas, Gloria" sort="Ribas, Gloria" uniqKey="Ribas G" first="Gloria" last="Ribas">Gloria Ribas</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<addr-line>Spanish National Cancer Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Centre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<addr-line>Spanish National Cancer Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Centre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<addr-line>Spanish National Cancer Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Centre, Madrid</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zamora, Pilar" sort="Zamora, Pilar" uniqKey="Zamora P" first="Pilar" last="Zamora">Pilar Zamora</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<addr-line>La Paz Hospital, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>La Paz Hospital, Madrid</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<addr-line>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<addr-line>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<addr-line>Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Deutsches Krebsforschungszentrum Heidelberg, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<addr-line>Evangelische Kliniken Bonn gGmhH Johanniter Krankenhaus, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Evangelische Kliniken Bonn gGmhH Johanniter Krankenhaus, Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bruening, Thomas" sort="Bruening, Thomas" uniqKey="Bruening T" first="Thomas" last="Bruening">Thomas Bruening</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<addr-line>Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr University Bochum, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr University Bochum</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Haas, Susanne" sort="Haas, Susanne" uniqKey="Haas S" first="Susanne" last="Haas">Susanne Haas</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<addr-line>Institute für Pathology, University Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute für Pathology, University Bonn, Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Karstens, Johann Hinrich" sort="Karstens, Johann Hinrich" uniqKey="Karstens J" first="Johann Hinrich" last="Karstens">Johann Hinrich Karstens</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fagerholm, Rainer" sort="Fagerholm, Rainer" uniqKey="Fagerholm R" first="Rainer" last="Fagerholm">Rainer Fagerholm</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<addr-line>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Aaltonen, Kirsimari" sort="Aaltonen, Kirsimari" uniqKey="Aaltonen K" first="Kirsimari" last="Aaltonen">Kirsimari Aaltonen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<addr-line>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<addr-line>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Von Smitten, Karl" sort="Von Smitten, Karl" uniqKey="Von Smitten K" first="Karl" last="Von Smitten">Karl Von Smitten</name>
<affiliation wicri:level="1">
<nlm:aff id="aff20">
<addr-line>Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Surgery, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<addr-line>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<addr-line>Department of Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uusitupa, Matti" sort="Uusitupa, Matti" uniqKey="Uusitupa M" first="Matti" last="Uusitupa">Matti Uusitupa</name>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<addr-line>Department of Public Health and Clinical Nutrition, Biocenter Kuopio, University of Kuopio, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Public Health and Clinical Nutrition, Biocenter Kuopio, University of Kuopio, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eskelinen, Matti" sort="Eskelinen, Matti" uniqKey="Eskelinen M" first="Matti" last="Eskelinen">Matti Eskelinen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<addr-line>Department of Surgery, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Surgery, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tengstrom, Maria" sort="Tengstrom, Maria" uniqKey="Tengstrom M" first="Maria" last="Tengström">Maria Tengström</name>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<addr-line>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<addr-line>Department of Oncology, Vaasa Central Hospital, Vaasa, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Vaasa Central Hospital, Vaasa</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<addr-line>Department of Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<addr-line>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Kuopio University Hospital, Kuopio</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<addr-line>Department of Oncology, Vaasa Central Hospital, Vaasa, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, Vaasa Central Hospital, Vaasa</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<addr-line>Departments of Human Genetics and Pathology, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Human Genetics and Pathology, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<addr-line>Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jacobi, Catharina E" sort="Jacobi, Catharina E" uniqKey="Jacobi C" first="Catharina E." last="Jacobi">Catharina E. Jacobi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<addr-line>Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Decision Making, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<addr-line>Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Huijts, Petra E A" sort="Huijts, Petra E A" uniqKey="Huijts P" first="Petra E. A." last="Huijts">Petra E. A. Huijts</name>
<affiliation wicri:level="1">
<nlm:aff id="aff33">
<addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Klijn, Jan G M" sort="Klijn, Jan G M" uniqKey="Klijn J" first="Jan G. M." last="Klijn">Jan G. M. Klijn</name>
<affiliation wicri:level="1">
<nlm:aff id="aff33">
<addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<addr-line>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kropp, Silke" sort="Kropp, Silke" uniqKey="Kropp S" first="Silke" last="Kropp">Silke Kropp</name>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<addr-line>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Slanger, Tracy" sort="Slanger, Tracy" uniqKey="Slanger T" first="Tracy" last="Slanger">Tracy Slanger</name>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<addr-line>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<addr-line>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mutschelknauss, Elke" sort="Mutschelknauss, Elke" uniqKey="Mutschelknauss E" first="Elke" last="Mutschelknauss">Elke Mutschelknauss</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<addr-line>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Salazar, Ramona" sort="Salazar, Ramona" uniqKey="Salazar R" first="Ramona" last="Salazar">Ramona Salazar</name>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<addr-line>Bioglobe GmbH, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bioglobe GmbH, Hamburg</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name>
<affiliation wicri:level="1">
<nlm:aff id="aff37">
<addr-line>Molecular Biology Laboratory, Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Biology Laboratory, Department of Obstetrics and Gynecology, University of Ulm, Ulm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Couch, Fergus" sort="Couch, Fergus" uniqKey="Couch F" first="Fergus" last="Couch">Fergus Couch</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S." last="Fredericksen">Zachary S. Fredericksen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic College of Medicine, Rochester, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<addr-line>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<addr-line>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<addr-line>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="1">
<nlm:aff id="aff40">
<addr-line>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name>
<affiliation wicri:level="1">
<nlm:aff id="aff40">
<addr-line>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="1">
<nlm:aff id="aff41">
<addr-line>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff42">
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff42">
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name>
<affiliation wicri:level="1">
<nlm:aff id="aff43">
<addr-line>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="1">
<nlm:aff id="aff43">
<addr-line>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff44">
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation wicri:level="1">
<nlm:aff id="aff45">
<addr-line>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff47">
<addr-line>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="1">
<nlm:aff id="aff47">
<addr-line>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="1">
<nlm:aff id="aff48">
<addr-line>Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
<affiliation wicri:level="1">
<nlm:aff id="aff49">
<addr-line>Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brinton, Louise A" sort="Brinton, Louise A" uniqKey="Brinton L" first="Louise A." last="Brinton">Louise A. Brinton</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name>
<affiliation wicri:level="1">
<nlm:aff id="aff50">
<addr-line>Nofer Institute of Occupational Medicine, Lodz, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Nofer Institute of Occupational Medicine, Lodz</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Klijn, Jan G M" sort="Klijn, Jan G M" uniqKey="Klijn J" first="Jan G. M." last="Klijn">Jan G. M. Klijn</name>
<affiliation wicri:level="1">
<nlm:aff id="aff51">
<addr-line>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation wicri:level="1">
<nlm:aff id="aff51">
<addr-line>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Meijers Heijboer, Han" sort="Meijers Heijboer, Han" uniqKey="Meijers Heijboer H" first="Han" last="Meijers-Heijboer">Han Meijers-Heijboer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collee">J. Margriet Collee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Den Ouweland, Ans" sort="Van Den Ouweland, Ans" uniqKey="Van Den Ouweland A" first="Ans" last="Van Den Ouweland">Ans Van Den Ouweland</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="1">
<nlm:aff id="aff53">
<addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<addr-line>Human Genetics, Genome Institute of Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lin, Low Yen" sort="Lin, Low Yen" uniqKey="Lin L" first="Low Yen" last="Lin">Low Yen Lin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<addr-line>Human Genetics, Genome Institute of Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yuqing, Li" sort="Yuqing, Li" uniqKey="Yuqing L" first="Li" last="Yuqing">Li Yuqing</name>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<addr-line>Human Genetics, Genome Institute of Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation wicri:level="1">
<nlm:aff id="aff55">
<addr-line>Institute for Cancer Studies, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Cancer Studies, Sheffield University Medical School, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Balasubramanian, Sabapathy P" sort="Balasubramanian, Sabapathy P" uniqKey="Balasubramanian S" first="Sabapathy P." last="Balasubramanian">Sabapathy P. Balasubramanian</name>
<affiliation wicri:level="1">
<nlm:aff id="aff56">
<addr-line>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<addr-line>Academic Unit of Pathology, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Pathology, Sheffield University Medical School, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name>
<affiliation wicri:level="1">
<nlm:aff id="aff56">
<addr-line>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dunning, Alison" sort="Dunning, Alison" uniqKey="Dunning A" first="Alison" last="Dunning">Alison Dunning</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<addr-line>Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK, Cambridge Research Institute, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">
<addr-line>Molecular Epidemiology Unit, National Cancer Institute, Ratchathewi, Bangkok, Thailand</addr-line>
</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Molecular Epidemiology Unit, National Cancer Institute, Ratchathewi, Bangkok</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gabrieau, Valerie" sort="Gabrieau, Valerie" uniqKey="Gabrieau V" first="Valerie" last="Gabrieau">Valerie Gabrieau</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sigurdson, Alice" sort="Sigurdson, Alice" uniqKey="Sigurdson A" first="Alice" last="Sigurdson">Alice Sigurdson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Doody, Michele" sort="Doody, Michele" uniqKey="Doody M" first="Michele" last="Doody">Michele Doody</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Struewing, Jeffrey P" sort="Struewing, Jeffrey P" uniqKey="Struewing J" first="Jeffrey P." last="Struewing">Jeffrey P. Struewing</name>
<affiliation>
<nlm:aff id="aff61">
<addr-line>Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, United Stated of America</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">United Stated of America</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Alexander, Bruce" sort="Alexander, Bruce" uniqKey="Alexander B" first="Bruce" last="Alexander">Bruce Alexander</name>
<affiliation wicri:level="1">
<nlm:aff id="aff62">
<addr-line>Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">PLoS Genetics</title>
<idno type="ISSN">1553-7390</idno>
<idno type="eISSN">1553-7404</idno>
<imprint>
<date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (
<italic>FGFR2</italic>
), trinucleotide repeat containing 9 (
<italic>TNRC9</italic>
), mitogen-activated protein kinase 3 K1 (
<italic>MAP3K1</italic>
), 8q24, and lymphocyte-specific protein 1 (
<italic>LSP1</italic>
)) associated with breast cancer risk. We investigated whether the associations between these SNPs and breast cancer risk varied by clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls from 20 studies. We also evaluated their influence on overall survival in 13,527 cases from 13 studies. All participants were of European or Asian origin. rs2981582 in
<italic>FGFR2</italic>
was more strongly related to ER-positive (per-allele OR (95%CI) = 1.31 (1.27–1.36)) than ER-negative (1.08 (1.03–1.14)) disease (P for heterogeneity = 10
<sup>−13</sup>
). This SNP was also more strongly related to PR-positive, low grade and node positive tumors (P = 10
<sup>−5</sup>
, 10
<sup>−8</sup>
, 0.013, respectively). The association for rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10
<sup>−4</sup>
, respectively). The differences in the associations between SNPs in
<italic>FGFR2</italic>
and 8q24 and risk by ER and grade remained significant after permutation adjustment for multiple comparisons and after adjustment for other tumor characteristics. Three SNPs (rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in
<italic>TNRC9</italic>
(1.14 (1.09–1.21)). rs13281615 in 8q24 was associated with an improvement in survival after diagnosis (per-allele HR = 0.90 (0.83–0.97). The association was attenuated and non-significant after adjusting for known prognostic factors. Our findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct. Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment.</p>
</div>
</front>
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</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">PLoS Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS Genet</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosgen</journal-id>
<journal-title-group>
<journal-title>PLoS Genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">1553-7390</issn>
<issn pub-type="epub">1553-7404</issn>
<publisher>
<publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">18437204</article-id>
<article-id pub-id-type="pmc">2291027</article-id>
<article-id pub-id-type="publisher-id">07-PLGE-RA-0661R5</article-id>
<article-id pub-id-type="doi">10.1371/journal.pgen.1000054</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline">
<subject>Genetics and Genomics/Genetics of Disease</subject>
<subject>Oncology/Breast Cancer</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics</article-title>
<alt-title alt-title-type="running-head">Breast Cancer Susceptibility and Pathology</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Garcia-Closas</surname>
<given-names>Montserrat</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">
<sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hall</surname>
<given-names>Per</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nevanlinna</surname>
<given-names>Heli</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pooley</surname>
<given-names>Karen</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Morrison</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Richesson</surname>
<given-names>Douglas A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bojesen</surname>
<given-names>Stig E.</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff6">
<sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nordestgaard</surname>
<given-names>Børge G.</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Axelsson</surname>
<given-names>Christen K.</given-names>
</name>
<xref ref-type="aff" rid="aff7">
<sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Arias</surname>
<given-names>Jose I.</given-names>
</name>
<xref ref-type="aff" rid="aff8">
<sup>8</sup>
</xref>
<xref ref-type="aff" rid="aff9">
<sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Milne</surname>
<given-names>Roger L.</given-names>
</name>
<xref ref-type="aff" rid="aff8">
<sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ribas</surname>
<given-names>Gloria</given-names>
</name>
<xref ref-type="aff" rid="aff8">
<sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>González-Neira</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="aff8">
<sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Benítez</surname>
<given-names>Javier</given-names>
</name>
<xref ref-type="aff" rid="aff8">
<sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zamora</surname>
<given-names>Pilar</given-names>
</name>
<xref ref-type="aff" rid="aff10">
<sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brauch</surname>
<given-names>Hiltrud</given-names>
</name>
<xref ref-type="aff" rid="aff11">
<sup>11</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Justenhoven</surname>
<given-names>Christina</given-names>
</name>
<xref ref-type="aff" rid="aff11">
<sup>11</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hamann</surname>
<given-names>Ute</given-names>
</name>
<xref ref-type="aff" rid="aff12">
<sup>12</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ko</surname>
<given-names>Yon-Dschun</given-names>
</name>
<xref ref-type="aff" rid="aff13">
<sup>13</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bruening</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="aff14">
<sup>14</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Haas</surname>
<given-names>Susanne</given-names>
</name>
<xref ref-type="aff" rid="aff15">
<sup>15</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dörk</surname>
<given-names>Thilo</given-names>
</name>
<xref ref-type="aff" rid="aff16">
<sup>16</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schürmann</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff16">
<sup>16</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hillemanns</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff16">
<sup>16</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bogdanova</surname>
<given-names>Natalia</given-names>
</name>
<xref ref-type="aff" rid="aff16">
<sup>16</sup>
</xref>
<xref ref-type="aff" rid="aff17">
<sup>17</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bremer</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="aff17">
<sup>17</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Karstens</surname>
<given-names>Johann Hinrich</given-names>
</name>
<xref ref-type="aff" rid="aff17">
<sup>17</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fagerholm</surname>
<given-names>Rainer</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Aaltonen</surname>
<given-names>Kirsimari</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff18">
<sup>18</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Aittomäki</surname>
<given-names>Kristiina</given-names>
</name>
<xref ref-type="aff" rid="aff19">
<sup>19</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>von Smitten</surname>
<given-names>Karl</given-names>
</name>
<xref ref-type="aff" rid="aff20">
<sup>20</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Blomqvist</surname>
<given-names>Carl</given-names>
</name>
<xref ref-type="aff" rid="aff18">
<sup>18</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mannermaa</surname>
<given-names>Arto</given-names>
</name>
<xref ref-type="aff" rid="aff21">
<sup>21</sup>
</xref>
<xref ref-type="aff" rid="aff22">
<sup>22</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Uusitupa</surname>
<given-names>Matti</given-names>
</name>
<xref ref-type="aff" rid="aff23">
<sup>23</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Eskelinen</surname>
<given-names>Matti</given-names>
</name>
<xref ref-type="aff" rid="aff24">
<sup>24</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tengström</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="aff25">
<sup>25</sup>
</xref>
<xref ref-type="aff" rid="aff26">
<sup>26</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kosma</surname>
<given-names>Veli-Matti</given-names>
</name>
<xref ref-type="aff" rid="aff21">
<sup>21</sup>
</xref>
<xref ref-type="aff" rid="aff22">
<sup>22</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kataja</surname>
<given-names>Vesa</given-names>
</name>
<xref ref-type="aff" rid="aff25">
<sup>25</sup>
</xref>
<xref ref-type="aff" rid="aff26">
<sup>26</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<xref ref-type="aff" rid="aff27">
<sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Spurdle</surname>
<given-names>Amanda B.</given-names>
</name>
<xref ref-type="aff" rid="aff27">
<sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Beesley</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="aff27">
<sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Xiaoqing</given-names>
</name>
<xref ref-type="aff" rid="aff27">
<sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Australian Ovarian Cancer Management Group</surname>
<given-names></given-names>
</name>
<xref ref-type="aff" rid="aff27">
<sup>27</sup>
</xref>
<xref ref-type="aff" rid="aff28">
<sup>28</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer</surname>
<given-names></given-names>
</name>
<xref ref-type="aff" rid="aff28">
<sup>28</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Devilee</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff29">
<sup>29</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van Asperen</surname>
<given-names>Christi J.</given-names>
</name>
<xref ref-type="aff" rid="aff30">
<sup>30</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jacobi</surname>
<given-names>Catharina E.</given-names>
</name>
<xref ref-type="aff" rid="aff31">
<sup>31</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tollenaar</surname>
<given-names>Rob A. E. M.</given-names>
</name>
<xref ref-type="aff" rid="aff32">
<sup>32</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Huijts</surname>
<given-names>Petra E.A.</given-names>
</name>
<xref ref-type="aff" rid="aff33">
<sup>33</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Klijn</surname>
<given-names>Jan G. M.</given-names>
</name>
<xref ref-type="aff" rid="aff33">
<sup>33</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chang-Claude</surname>
<given-names>Jenny</given-names>
</name>
<xref ref-type="aff" rid="aff34">
<sup>34</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kropp</surname>
<given-names>Silke</given-names>
</name>
<xref ref-type="aff" rid="aff34">
<sup>34</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Slanger</surname>
<given-names>Tracy</given-names>
</name>
<xref ref-type="aff" rid="aff34">
<sup>34</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Flesch-Janys</surname>
<given-names>Dieter</given-names>
</name>
<xref ref-type="aff" rid="aff35">
<sup>35</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mutschelknauss</surname>
<given-names>Elke</given-names>
</name>
<xref ref-type="aff" rid="aff35">
<sup>35</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Salazar</surname>
<given-names>Ramona</given-names>
</name>
<xref ref-type="aff" rid="aff36">
<sup>36</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang-Gohrke</surname>
<given-names>Shan</given-names>
</name>
<xref ref-type="aff" rid="aff37">
<sup>37</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Couch</surname>
<given-names>Fergus</given-names>
</name>
<xref ref-type="aff" rid="aff38">
<sup>38</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Goode</surname>
<given-names>Ellen L.</given-names>
</name>
<xref ref-type="aff" rid="aff38">
<sup>38</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Olson</surname>
<given-names>Janet E.</given-names>
</name>
<xref ref-type="aff" rid="aff38">
<sup>38</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Vachon</surname>
<given-names>Celine</given-names>
</name>
<xref ref-type="aff" rid="aff38">
<sup>38</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fredericksen</surname>
<given-names>Zachary S.</given-names>
</name>
<xref ref-type="aff" rid="aff38">
<sup>38</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Giles</surname>
<given-names>Graham G.</given-names>
</name>
<xref ref-type="aff" rid="aff39">
<sup>39</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Baglietto</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="aff39">
<sup>39</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Severi</surname>
<given-names>Gianluca</given-names>
</name>
<xref ref-type="aff" rid="aff39">
<sup>39</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hopper</surname>
<given-names>John L.</given-names>
</name>
<xref ref-type="aff" rid="aff40">
<sup>40</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>English</surname>
<given-names>Dallas R.</given-names>
</name>
<xref ref-type="aff" rid="aff40">
<sup>40</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Southey</surname>
<given-names>Melissa C.</given-names>
</name>
<xref ref-type="aff" rid="aff41">
<sup>41</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Haiman</surname>
<given-names>Christopher A.</given-names>
</name>
<xref ref-type="aff" rid="aff42">
<sup>42</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Henderson</surname>
<given-names>Brian E.</given-names>
</name>
<xref ref-type="aff" rid="aff42">
<sup>42</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kolonel</surname>
<given-names>Laurence N.</given-names>
</name>
<xref ref-type="aff" rid="aff43">
<sup>43</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Le Marchand</surname>
<given-names>Loic</given-names>
</name>
<xref ref-type="aff" rid="aff43">
<sup>43</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stram</surname>
<given-names>Daniel O.</given-names>
</name>
<xref ref-type="aff" rid="aff44">
<sup>44</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hunter</surname>
<given-names>David J.</given-names>
</name>
<xref ref-type="aff" rid="aff45">
<sup>45</sup>
</xref>
<xref ref-type="aff" rid="aff46">
<sup>46</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hankinson</surname>
<given-names>Susan E.</given-names>
</name>
<xref ref-type="aff" rid="aff46">
<sup>46</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cox</surname>
<given-names>David G.</given-names>
</name>
<xref ref-type="aff" rid="aff46">
<sup>46</sup>
</xref>
<xref ref-type="aff" rid="aff47">
<sup>47</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tamimi</surname>
<given-names>Rulla</given-names>
</name>
<xref ref-type="aff" rid="aff46">
<sup>46</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kraft</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff47">
<sup>47</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sherman</surname>
<given-names>Mark E.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chanock</surname>
<given-names>Stephen J.</given-names>
</name>
<xref ref-type="aff" rid="aff48">
<sup>48</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lissowska</surname>
<given-names>Jolanta</given-names>
</name>
<xref ref-type="aff" rid="aff49">
<sup>49</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brinton</surname>
<given-names>Louise A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Peplonska</surname>
<given-names>Beata</given-names>
</name>
<xref ref-type="aff" rid="aff50">
<sup>50</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Klijn</surname>
<given-names>Jan G. M.</given-names>
</name>
<xref ref-type="aff" rid="aff51">
<sup>51</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hooning</surname>
<given-names>Maartje J.</given-names>
</name>
<xref ref-type="aff" rid="aff51">
<sup>51</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Meijers-Heijboer</surname>
<given-names>Han</given-names>
</name>
<xref ref-type="aff" rid="aff52">
<sup>52</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Collee</surname>
<given-names>J. Margriet</given-names>
</name>
<xref ref-type="aff" rid="aff52">
<sup>52</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van den Ouweland</surname>
<given-names>Ans</given-names>
</name>
<xref ref-type="aff" rid="aff52">
<sup>52</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Uitterlinden</surname>
<given-names>Andre G.</given-names>
</name>
<xref ref-type="aff" rid="aff53">
<sup>53</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Liu</surname>
<given-names>Jianjun</given-names>
</name>
<xref ref-type="aff" rid="aff54">
<sup>54</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lin</surname>
<given-names>Low Yen</given-names>
</name>
<xref ref-type="aff" rid="aff54">
<sup>54</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yuqing</surname>
<given-names>Li</given-names>
</name>
<xref ref-type="aff" rid="aff54">
<sup>54</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Humphreys</surname>
<given-names>Keith</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Czene</surname>
<given-names>Kamila</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cox</surname>
<given-names>Angela</given-names>
</name>
<xref ref-type="aff" rid="aff55">
<sup>55</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Balasubramanian</surname>
<given-names>Sabapathy P.</given-names>
</name>
<xref ref-type="aff" rid="aff56">
<sup>56</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cross</surname>
<given-names>Simon S.</given-names>
</name>
<xref ref-type="aff" rid="aff57">
<sup>57</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Reed</surname>
<given-names>Malcolm W. R.</given-names>
</name>
<xref ref-type="aff" rid="aff56">
<sup>56</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Blows</surname>
<given-names>Fiona</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Driver</surname>
<given-names>Kristy</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dunning</surname>
<given-names>Alison</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tyrer</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ponder</surname>
<given-names>Bruce A. J.</given-names>
</name>
<xref ref-type="aff" rid="aff58">
<sup>58</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sangrajrang</surname>
<given-names>Suleeporn</given-names>
</name>
<xref ref-type="aff" rid="aff59">
<sup>59</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brennan</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="aff60">
<sup>60</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>McKay</surname>
<given-names>James</given-names>
</name>
<xref ref-type="aff" rid="aff60">
<sup>60</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Odefrey</surname>
<given-names>Fabrice</given-names>
</name>
<xref ref-type="aff" rid="aff60">
<sup>60</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gabrieau</surname>
<given-names>Valerie</given-names>
</name>
<xref ref-type="aff" rid="aff60">
<sup>60</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sigurdson</surname>
<given-names>Alice</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Doody</surname>
<given-names>Michele</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Struewing</surname>
<given-names>Jeffrey P.</given-names>
</name>
<xref ref-type="aff" rid="aff61">
<sup>61</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alexander</surname>
<given-names>Bruce</given-names>
</name>
<xref ref-type="aff" rid="aff62">
<sup>62</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Easton</surname>
<given-names>Douglas F.</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pharoah</surname>
<given-names>Paul D.</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1">
<label>1</label>
<addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America</addr-line>
</aff>
<aff id="aff2">
<label>2</label>
<addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</addr-line>
</aff>
<aff id="aff3">
<label>3</label>
<addr-line>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</aff>
<aff id="aff4">
<label>4</label>
<addr-line>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</aff>
<aff id="aff5">
<label>5</label>
<addr-line>Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen, Denmark</addr-line>
</aff>
<aff id="aff6">
<label>6</label>
<addr-line>Department of Bispebjerg University Hospitals, University of Copenhagen, Denmark</addr-line>
</aff>
<aff id="aff7">
<label>7</label>
<addr-line>Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Denmark</addr-line>
</aff>
<aff id="aff8">
<label>8</label>
<addr-line>Spanish National Cancer Centre, Madrid, Spain</addr-line>
</aff>
<aff id="aff9">
<label>9</label>
<addr-line>Monte Naranco Hospital, Oviedo, Spain</addr-line>
</aff>
<aff id="aff10">
<label>10</label>
<addr-line>La Paz Hospital, Madrid, Spain</addr-line>
</aff>
<aff id="aff11">
<label>11</label>
<addr-line>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany</addr-line>
</aff>
<aff id="aff12">
<label>12</label>
<addr-line>Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany</addr-line>
</aff>
<aff id="aff13">
<label>13</label>
<addr-line>Evangelische Kliniken Bonn gGmhH Johanniter Krankenhaus, Bonn, Germany</addr-line>
</aff>
<aff id="aff14">
<label>14</label>
<addr-line>Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr University Bochum, Germany</addr-line>
</aff>
<aff id="aff15">
<label>15</label>
<addr-line>Institute für Pathology, University Bonn, Bonn, Germany</addr-line>
</aff>
<aff id="aff16">
<label>16</label>
<addr-line>Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany</addr-line>
</aff>
<aff id="aff17">
<label>17</label>
<addr-line>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</addr-line>
</aff>
<aff id="aff18">
<label>18</label>
<addr-line>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</aff>
<aff id="aff19">
<label>19</label>
<addr-line>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</aff>
<aff id="aff20">
<label>20</label>
<addr-line>Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland</addr-line>
</aff>
<aff id="aff21">
<label>21</label>
<addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio, Finland</addr-line>
</aff>
<aff id="aff22">
<label>22</label>
<addr-line>Department of Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</aff>
<aff id="aff23">
<label>23</label>
<addr-line>Department of Public Health and Clinical Nutrition, Biocenter Kuopio, University of Kuopio, Kuopio, Finland</addr-line>
</aff>
<aff id="aff24">
<label>24</label>
<addr-line>Department of Surgery, Kuopio University Hospital, Kuopio, Finland</addr-line>
</aff>
<aff id="aff25">
<label>25</label>
<addr-line>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</aff>
<aff id="aff26">
<label>26</label>
<addr-line>Department of Oncology, Vaasa Central Hospital, Vaasa, Finland</addr-line>
</aff>
<aff id="aff27">
<label>27</label>
<addr-line>The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia</addr-line>
</aff>
<aff id="aff28">
<label>28</label>
<addr-line>Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia</addr-line>
</aff>
<aff id="aff29">
<label>29</label>
<addr-line>Departments of Human Genetics and Pathology, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</aff>
<aff id="aff30">
<label>30</label>
<addr-line>Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</aff>
<aff id="aff31">
<label>31</label>
<addr-line>Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</aff>
<aff id="aff32">
<label>32</label>
<addr-line>Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</aff>
<aff id="aff33">
<label>33</label>
<addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</addr-line>
</aff>
<aff id="aff34">
<label>34</label>
<addr-line>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</addr-line>
</aff>
<aff id="aff35">
<label>35</label>
<addr-line>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</aff>
<aff id="aff36">
<label>36</label>
<addr-line>Bioglobe GmbH, Hamburg, Germany</addr-line>
</aff>
<aff id="aff37">
<label>37</label>
<addr-line>Molecular Biology Laboratory, Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</addr-line>
</aff>
<aff id="aff38">
<label>38</label>
<addr-line>Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America</addr-line>
</aff>
<aff id="aff39">
<label>39</label>
<addr-line>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia</addr-line>
</aff>
<aff id="aff40">
<label>40</label>
<addr-line>Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</aff>
<aff id="aff41">
<label>41</label>
<addr-line>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</aff>
<aff id="aff42">
<label>42</label>
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</aff>
<aff id="aff43">
<label>43</label>
<addr-line>Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America</addr-line>
</aff>
<aff id="aff44">
<label>44</label>
<addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</aff>
<aff id="aff45">
<label>45</label>
<addr-line>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</aff>
<aff id="aff46">
<label>46</label>
<addr-line>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</aff>
<aff id="aff47">
<label>47</label>
<addr-line>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line>
</aff>
<aff id="aff48">
<label>48</label>
<addr-line>Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, United States of America</addr-line>
</aff>
<aff id="aff49">
<label>49</label>
<addr-line>Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw, Poland</addr-line>
</aff>
<aff id="aff50">
<label>50</label>
<addr-line>Nofer Institute of Occupational Medicine, Lodz, Poland</addr-line>
</aff>
<aff id="aff51">
<label>51</label>
<addr-line>Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam, The Netherlands</addr-line>
</aff>
<aff id="aff52">
<label>52</label>
<addr-line>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</aff>
<aff id="aff53">
<label>53</label>
<addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line>
</aff>
<aff id="aff54">
<label>54</label>
<addr-line>Human Genetics, Genome Institute of Singapore, Singapore</addr-line>
</aff>
<aff id="aff55">
<label>55</label>
<addr-line>Institute for Cancer Studies, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</aff>
<aff id="aff56">
<label>56</label>
<addr-line>Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</aff>
<aff id="aff57">
<label>57</label>
<addr-line>Academic Unit of Pathology, Sheffield University Medical School, Sheffield, United Kingdom</addr-line>
</aff>
<aff id="aff58">
<label>58</label>
<addr-line>Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom</addr-line>
</aff>
<aff id="aff59">
<label>59</label>
<addr-line>Molecular Epidemiology Unit, National Cancer Institute, Ratchathewi, Bangkok, Thailand</addr-line>
</aff>
<aff id="aff60">
<label>60</label>
<addr-line>International Agency for Research on Cancer, Lyon, France</addr-line>
</aff>
<aff id="aff61">
<label>61</label>
<addr-line>Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, United Stated of America</addr-line>
</aff>
<aff id="aff62">
<label>62</label>
<addr-line>Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</aff>
<contrib-group>
<contrib contrib-type="editor">
<name>
<surname>Leal</surname>
<given-names>Suzanne M.</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1">Baylor College of Medicine, United States of America</aff>
<author-notes>
<corresp id="cor1">* E-mail:
<email>montse@nih.gov</email>
</corresp>
<fn fn-type="con">
<p>Conceived and designed the experiments: M. Garcia-Closas, P. Hall, S. Bojesen, B. Nordestgaard, C. Axelsson, T. Dörk, J. Chang-Claude, D. Flesch-Janys, D. Hunter, S. Hankinson, D. Cox, R. Tamimi, P. Kraft, P. Brennan, J. McKay, D. Easton, P. Pharoah. Performed the experiments: K. Pooley, R. Milne, G. Ribas, A. González-Neira, J. Benítez, H. Brauch, C. Justenhoven, T. Dörk, P. Schürmann, N. Bogdanova, A. Mannermaa, J. Beesley, X. Chen, J. Chang-Claude, R. Salazar, S. Wang-Gohrke, F. Couch, M. Southey, D. Hunter, D. Cox, S. Chanock, J. Liu, A. Dunning, F. Odefrey, J. Struewing. Analyzed the data: M. Garcia-Closas, D. Richesson, T. Dörk, M. Tengström, V. Kataja, P. Huijts, S. Kropp, D. Flesch-Janys, P. Kraft, J. Tyrer, V. Gabrieau. Contributed reagents/materials/analysis tools: M. Garcia-Closas, P. Hall, H. Nevanlinna, K. Pooley, J. Morrison, S. Bojesen, B. Nordestgaard, C. Axelsson, H. Brauch, P. Hillemanns, M. Bremer, J. Karstens, R. Fagerholm, K. Aaltonen, K. Aittomäki, K. von Smitten, C. Blomqvist, M. Uusitupa, M. Eskelinen, V. Kosma, G. Chenevix-Trench, A. Spurdle, Australian Ovarian Cancer Management Group, The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, P. Devilee, C. van Asperen, R. Tollenaar, J. Chang-Claude, D. Flesch-Janys, F. Couch, J. Olson, G. Giles, C. Haiman, B. Henderson, L. Kolonel, L. Le Marchand, D. Stram, A. Uitterlinden, J. Liu, K. Humphreys, K. Czene, J. Struewing. Wrote the paper: M. Garcia-Closas, P. Hall, H. Nevanlinna, P. Pharoah. Study design/data collection: M. Garcia-Closas, P. Hall, H. Nevanlinna, J. Morrison, J. Arias, P. Zamora, H. Brauch, C. Justenhoven, U. Hamann, Y. Ko, T. Bruening, S. Haas, R. Fagerholm, K. Aaltonen, A. Mannermaa, M. Uusitupa, M. Eskelinen, M. Tengström, V. Kosma, V. Kataja, G. Chenevix-Trench, A. Spurdle, C. van Asperen, C. Jacobi, R. Tollenaar, J. Klijn, T. Slanger, E. Mutschelknauss, F. Couch, E. Goode, J. Olson, C. Vachon, Z. Fredericksen, G. Giles, L. Baglietto, G. Severi, J. Hopper, D. English, M. Southey, C. Haiman, B. Henderson, L. Kolonel, L. Le Marchand, D. Stram, D. Hunter, S. Hankinson, R. Tamimi, M. Sherman, J. Lissowska, L. Brinton, B. Peplonska, J. Klijn, M. Hooning, H. Meijers-Heijboer, J. Collee, A. Ouweland, J. Liu, L. Lin, L. Yuqing, A. Cox, S. Balasubramanian, M. Reed, F. Blows, K. Driver, A. Dunning, B. Ponder, S. Sangrajrang, A. Sigurdson, M. Doody, B. Alexander, D. Easton, P. Pharoah. Pathology review: J. Arias, P. Zamora, S. Haas, M. Bremer, V. Kosma, M. Sherman, S. Cross, F. Blows, K. Driver.</p>
</fn>
</author-notes>
<pub-date pub-type="collection">
<month>4</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="epub">
<day>25</day>
<month>4</month>
<year>2008</year>
</pub-date>
<volume>4</volume>
<issue>4</issue>
<elocation-id>e1000054</elocation-id>
<history>
<date date-type="received">
<day>16</day>
<month>8</month>
<year>2007</year>
</date>
<date date-type="accepted">
<day>18</day>
<month>3</month>
<year>2008</year>
</date>
</history>
<permissions>
<copyright-statement>This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.</copyright-statement>
<copyright-year>2008</copyright-year>
<license xlink:href="https://creativecommons.org/publicdomain/zero/1.0/">
<license-p>This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.</license-p>
</license>
</permissions>
<abstract>
<p>A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (
<italic>FGFR2</italic>
), trinucleotide repeat containing 9 (
<italic>TNRC9</italic>
), mitogen-activated protein kinase 3 K1 (
<italic>MAP3K1</italic>
), 8q24, and lymphocyte-specific protein 1 (
<italic>LSP1</italic>
)) associated with breast cancer risk. We investigated whether the associations between these SNPs and breast cancer risk varied by clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls from 20 studies. We also evaluated their influence on overall survival in 13,527 cases from 13 studies. All participants were of European or Asian origin. rs2981582 in
<italic>FGFR2</italic>
was more strongly related to ER-positive (per-allele OR (95%CI) = 1.31 (1.27–1.36)) than ER-negative (1.08 (1.03–1.14)) disease (P for heterogeneity = 10
<sup>−13</sup>
). This SNP was also more strongly related to PR-positive, low grade and node positive tumors (P = 10
<sup>−5</sup>
, 10
<sup>−8</sup>
, 0.013, respectively). The association for rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10
<sup>−4</sup>
, respectively). The differences in the associations between SNPs in
<italic>FGFR2</italic>
and 8q24 and risk by ER and grade remained significant after permutation adjustment for multiple comparisons and after adjustment for other tumor characteristics. Three SNPs (rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in
<italic>TNRC9</italic>
(1.14 (1.09–1.21)). rs13281615 in 8q24 was associated with an improvement in survival after diagnosis (per-allele HR = 0.90 (0.83–0.97). The association was attenuated and non-significant after adjusting for known prognostic factors. Our findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct. Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment.</p>
</abstract>
<abstract abstract-type="summary">
<title>Author Summary</title>
<p>This report from the Breast Cancer Association Consortium evaluates whether common variants in five recently identified breast cancer susceptibility loci (
<italic>FGFR2</italic>
,
<italic>TNRC9</italic>
,
<italic>MAP3K1</italic>
, 8q24, and
<italic>LSP1</italic>
) influence the clinical presentation of breast cancer and survival after diagnosis. We studied these susceptibility loci in relation to clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls of European or Asian origin from 20 studies. The association, with overall survival, was evaluated in 13,527 cases from 13 studies. The most notable findings were that the genetic variants in the fibroblast growth factor receptor 2 (
<italic>FGFR2</italic>
) gene and the 8q24 region were more strongly related to ER-positive than ER-negative disease, and to low rather than high grade tumors. The loci did not significantly influence survival after accounting for known prognostic factors. Analyses indicated that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative diseases are biologically distinct tumors. Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment.</p>
</abstract>
<counts>
<page-count count="10"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

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