AustralieFrV1, Pmc, Curation, bibRecord, 002665

In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Identifieur interne : 002665 ( Pmc/Curation ); précédent : 002664; suivant : 002666

In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Auteurs : Massilva Rahmoun [France] ; Rowena Lavery [Australie] ; Sabine Laurent-Chaballier [France] ; Nicolas Bellora [Argentine] ; Gayle K. Philip [Australie] ; Moïra Rossitto [France] ; Aleisha Symon [Australie] ; Eric Pailhoux [France] ; Florence Cammas [France] ; Jessica Chung [Australie] ; Stefan Bagheri-Fam [Australie] ; Mark Murphy [États-Unis] ; Vivian Bardwell [États-Unis] ; David Zarkower [États-Unis] ; Brigitte Boizet-Bonhoure [France] ; Philippe Clair [France] ; Vincent R. Harley [Australie] ; Francis Poulat [France]

Source :

Nucleic Acids Research [ 0305-1048 ] ; 2017.

RBID : PMC:5499551

Abstract

In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9, we combined analysis of SOX9-bound chromatin regions from murine and bovine foetal testes with sequencing of RNA samples from mouse testes lacking Sox9. We found that SOX9 controls a conserved genetic programme that involves most of the sex-determining genes. In foetal testes, SOX9 modulates both transcription and directly or indirectly sex-specific differential splicing of its target genes through binding to genomic regions with sequence motifs that are conserved among mammals and that we called ‘Sertoli Cell Signature’ (SCS). The SCS is characterized by a precise organization of binding motifs for the Sertoli cell reprogramming factors SOX9, GATA4 and DMRT1. As SOX9 biological role in mammalian gonads is to determine Sertoli cells, we correlated this genomic signature with the presence of SOX9 on chromatin in foetal testes, therefore equating this signature to a genomic bar code of the fate of foetal Sertoli cells. Starting from the hypothesis that nuclear factors that bind to genomic regions with SCS could functionally interact with SOX9, we identified TRIM28 as a new SOX9 partner in foetal testes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499551

DOI: 10.1093/nar/gkx328
PubMed: 28472341
PubMed Central: 5499551

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<author><name sortKey="Symon, Aleisha" sort="Symon, Aleisha" uniqKey="Symon A" first="Aleisha" last="Symon">Aleisha Symon</name>
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<author><name sortKey="Pailhoux, Eric" sort="Pailhoux, Eric" uniqKey="Pailhoux E" first="Eric" last="Pailhoux">Eric Pailhoux</name>
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<author><name sortKey="Chung, Jessica" sort="Chung, Jessica" uniqKey="Chung J" first="Jessica" last="Chung">Jessica Chung</name>
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<author><name sortKey="Bagheri Fam, Stefan" sort="Bagheri Fam, Stefan" uniqKey="Bagheri Fam S" first="Stefan" last="Bagheri-Fam">Stefan Bagheri-Fam</name>
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<author><name sortKey="Murphy, Mark" sort="Murphy, Mark" uniqKey="Murphy M" first="Mark" last="Murphy">Mark Murphy</name>
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<author><name sortKey="Bardwell, Vivian" sort="Bardwell, Vivian" uniqKey="Bardwell V" first="Vivian" last="Bardwell">Vivian Bardwell</name>
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<author><name sortKey="Zarkower, David" sort="Zarkower, David" uniqKey="Zarkower D" first="David" last="Zarkower">David Zarkower</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson hall, 321 Church St, SE, Minneapolis, MN 55455</wicri:regionArea>
</affiliation>
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<author><name sortKey="Boizet Bonhoure, Brigitte" sort="Boizet Bonhoure, Brigitte" uniqKey="Boizet Bonhoure B" first="Brigitte" last="Boizet-Bonhoure">Brigitte Boizet-Bonhoure</name>
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<country xml:lang="fr">France</country>
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</affiliation>
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<author><name sortKey="Clair, Philippe" sort="Clair, Philippe" uniqKey="Clair P" first="Philippe" last="Clair">Philippe Clair</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>University of Montpellier, Montpellier GenomiX, bat 24, Place Eugène Bataillon, 34095 Montpellier cedex 5</wicri:regionArea>
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<author><name sortKey="Harley, Vincent R" sort="Harley, Vincent R" uniqKey="Harley V" first="Vincent R." last="Harley">Vincent R. Harley</name>
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<country xml:lang="fr">Australie</country>
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</affiliation>
</author>
<author><name sortKey="Poulat, Francis" sort="Poulat, Francis" uniqKey="Poulat F" first="Francis" last="Poulat">Francis Poulat</name>
<affiliation wicri:level="1"><nlm:aff id="AFF1">Institute of Human Genetics, CNRS-University of Montpellier UMR9002, 34396 Montpellier cedex 5, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute of Human Genetics, CNRS-University of Montpellier UMR9002, 34396 Montpellier cedex 5</wicri:regionArea>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9, we combined analysis of SOX9-bound chromatin regions from murine and bovine foetal testes with sequencing of RNA samples from mouse testes lacking <italic>Sox9</italic>
. We found that SOX9 controls a conserved genetic programme that involves most of the sex-determining genes. In foetal testes, SOX9 modulates both transcription and directly or indirectly sex-specific differential splicing of its target genes through binding to genomic regions with sequence motifs that are conserved among mammals and that we called ‘Sertoli Cell Signature’ (SCS). The SCS is characterized by a precise organization of binding motifs for the Sertoli cell reprogramming factors SOX9, GATA4 and DMRT1. As SOX9 biological role in mammalian gonads is to determine Sertoli cells, we correlated this genomic signature with the presence of SOX9 on chromatin in foetal testes, therefore equating this signature to a genomic bar code of the fate of foetal Sertoli cells. Starting from the hypothesis that nuclear factors that bind to genomic regions with SCS could functionally interact with SOX9, we identified TRIM28 as a new SOX9 partner in foetal testes.</p>
</div>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Nucleic Acids Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Nucleic Acids Res</journal-id>
<journal-id journal-id-type="publisher-id">nar</journal-id>
<journal-title-group><journal-title>Nucleic Acids Research</journal-title>
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<issn pub-type="ppub">0305-1048</issn>
<issn pub-type="epub">1362-4962</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28472341</article-id>
<article-id pub-id-type="pmc">5499551</article-id>
<article-id pub-id-type="doi">10.1093/nar/gkx328</article-id>
<article-id pub-id-type="publisher-id">gkx328</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Gene regulation, Chromatin and Epigenetics</subject>
</subj-group>
</article-categories>
<title-group><article-title>In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Rahmoun</surname>
<given-names>Massilva</given-names>
</name>
<xref ref-type="aff" rid="AFF1">1</xref>
<xref ref-type="corresp" rid="COR2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lavery</surname>
<given-names>Rowena</given-names>
</name>
<xref ref-type="aff" rid="AFF2">2</xref>
<xref ref-type="corresp" rid="COR2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Laurent-Chaballier</surname>
<given-names>Sabine</given-names>
</name>
<xref ref-type="aff" rid="AFF3">3</xref>
<xref ref-type="corresp" rid="COR3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bellora</surname>
<given-names>Nicolas</given-names>
</name>
<xref ref-type="aff" rid="AFF4">4</xref>
<xref ref-type="corresp" rid="COR3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Philip</surname>
<given-names>Gayle K.</given-names>
</name>
<xref ref-type="aff" rid="AFF5">5</xref>
<xref ref-type="corresp" rid="COR3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rossitto</surname>
<given-names>Moïra</given-names>
</name>
<xref ref-type="aff" rid="AFF1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Symon</surname>
<given-names>Aleisha</given-names>
</name>
<xref ref-type="aff" rid="AFF2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pailhoux</surname>
<given-names>Eric</given-names>
</name>
<xref ref-type="aff" rid="AFF6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cammas</surname>
<given-names>Florence</given-names>
</name>
<xref ref-type="aff" rid="AFF3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chung</surname>
<given-names>Jessica</given-names>
</name>
<xref ref-type="aff" rid="AFF5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bagheri-Fam</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="AFF2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Murphy</surname>
<given-names>Mark</given-names>
</name>
<xref ref-type="aff" rid="AFF7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bardwell</surname>
<given-names>Vivian</given-names>
</name>
<xref ref-type="aff" rid="AFF7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zarkower</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="AFF7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boizet-Bonhoure</surname>
<given-names>Brigitte</given-names>
</name>
<xref ref-type="aff" rid="AFF1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Clair</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="AFF8">8</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Harley</surname>
<given-names>Vincent R.</given-names>
</name>
<pmc-comment>vincent.harley@hudson.org.au</pmc-comment>
          <xref ref-type="aff" rid="AFF2">2</xref>
<xref ref-type="corresp" rid="COR1"></xref>
<xref ref-type="corresp" rid="COR4"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Poulat</surname>
<given-names>Francis</given-names>
</name>
<pmc-comment>francis.poulat@igh.cnrs.fr</pmc-comment>
          <xref ref-type="aff" rid="AFF1">1</xref>
<xref ref-type="corresp" rid="COR1"></xref>
<xref ref-type="corresp" rid="COR4"></xref>
</contrib>
</contrib-group>
<aff id="AFF1"><label>1</label>
Institute of Human Genetics, CNRS-University of Montpellier UMR9002, 34396 Montpellier cedex 5, France</aff>
<aff id="AFF2"><label>2</label>
The Hudson Institute of Medical Research and Department of Anatomy, Monash University, Melbourne, Australia</aff>
<aff id="AFF3"><label>3</label>
Institut de Recherche en Cancérologie de Montpellier, IRCM, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier F-34298, France</aff>
<aff id="AFF4"><label>4</label>
Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales (IPATEC), Universidad Nacional del Comahue - CONICET, Bariloche, Argentina</aff>
<aff id="AFF5"><label>5</label>
VLSCI, LAB-14, 700 Swanston Street, Carlton 3053, Victoria, Australia</aff>
<aff id="AFF6"><label>6</label>
INRA Biologie du Développement et Reproduction, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France</aff>
<aff id="AFF7"><label>7</label>
Department of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson hall, 321 Church St, SE, Minneapolis, MN 55455, USA</aff>
<aff id="AFF8"><label>8</label>
University of Montpellier, Montpellier GenomiX, bat 24, Place Eugène Bataillon, 34095 Montpellier cedex 5, France</aff>
<author-notes><corresp id="COR1"><label>*</label>
To whom correspondence should be addressed. Tel: +33 4 34 35 99 40; Fax: +33 4 34 35 99 01; Email: <email>francis.poulat@igh.cnrs.fr</email>
. Correspondence may also be addressed to Vincent R Harley. Email: <email>vincent.harley@hudson.org.au</email>
</corresp>
<corresp id="COR2"><label>†</label>
These authors contributed equally to this work as first authors.</corresp>
<corresp id="COR3"><label>‡</label>
These authors contributed equally to this work as second authors.</corresp>
<corresp id="COR4"><label>§</label>
These authors contributed equally to this work as last authors.</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>07</day>
<month>7</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub" iso-8601-date="2017-05-02"><day>02</day>
<month>5</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>02</day>
<month>5</month>
<year>2017</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the . </pmc-comment>
      <volume>45</volume>
<issue>12</issue>
<fpage>7191</fpage>
<lpage>7211</lpage>
<history><date date-type="accepted"><day>17</day>
<month>4</month>
<year>2017</year>
</date>
<date date-type="rev-recd"><day>23</day>
<month>3</month>
<year>2017</year>
</date>
<date date-type="received"><day>24</day>
<month>8</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.</copyright-statement>
<copyright-year>2017</copyright-year>
<license license-type="cc-by-nc" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<uri xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</uri>
), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact <email>journals.permissions@oup.com</email>
</license-p>
</license>
</permissions>
<self-uri xlink:href="gkx328.pdf"></self-uri>
<abstract><title>Abstract</title>
<p>In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9, we combined analysis of SOX9-bound chromatin regions from murine and bovine foetal testes with sequencing of RNA samples from mouse testes lacking <italic>Sox9</italic>
. We found that SOX9 controls a conserved genetic programme that involves most of the sex-determining genes. In foetal testes, SOX9 modulates both transcription and directly or indirectly sex-specific differential splicing of its target genes through binding to genomic regions with sequence motifs that are conserved among mammals and that we called ‘Sertoli Cell Signature’ (SCS). The SCS is characterized by a precise organization of binding motifs for the Sertoli cell reprogramming factors SOX9, GATA4 and DMRT1. As SOX9 biological role in mammalian gonads is to determine Sertoli cells, we correlated this genomic signature with the presence of SOX9 on chromatin in foetal testes, therefore equating this signature to a genomic bar code of the fate of foetal Sertoli cells. Starting from the hypothesis that nuclear factors that bind to genomic regions with SCS could functionally interact with SOX9, we identified TRIM28 as a new SOX9 partner in foetal testes.</p>
</abstract>
<counts><page-count count="21"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

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In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

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