Changes in IgE sensitization and total IgE levels over 20 years of follow-up
Identifieur interne : 002469 ( Pmc/Curation ); précédent : 002468; suivant : 002470Changes in IgE sensitization and total IgE levels over 20 years of follow-up
Auteurs : André F. S. Amaral [Royaume-Uni] ; Roger B. Newson [Royaume-Uni] ; Michael J. Abramson [Australie] ; Josep M. Ant [Espagne] ; Roberto Bono [Italie] ; Angelo G. Corsico [Italie] ; Roberto De Marco [Italie] ; Pascal Demoly [France] ; Bertil Forsberg [Suède] ; Thorarinn Gislason [Islande] ; Joachim Heinrich [Allemagne] ; Ismael Huerta [Espagne] ; Christer Janson [Suède] ; Rain J Gi [Estonie] ; Jeong-Lim Kim [Suède] ; José Maldonado [Espagne] ; Jesús Martinez-Moratalla Rovira [Espagne] ; Catherine Neukirch [France] ; Dennis Nowak [Allemagne] ; Isabelle Pin [France] ; Nicole Probst-Hensch [Suisse] ; Chantal Raherison-Semjen [France] ; Cecilie Svanes [Norvège] ; Isabel Urrutia Landa [Espagne] ; Ronald Van Ree [Pays-Bas] ; Serge A. Versteeg [Pays-Bas] ; Joost Weyler [Belgique] ; Jan-Paul Zock [Espagne] ; Peter G. J. Burney [Royaume-Uni] ; Deborah L. Jarvis [Royaume-Uni]Source :
- The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 2016.
Abstract
Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect.
We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period.
Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse.
Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (−4.6%; 95% CI, −7.0% to −2.1%). The prevalence of sensitization to house dust mite (−4.3%; 95% CI, −6.0% to −2.6%) and cat (−2.1%; 95% CI, −3.6% to −0.7%) decreased more than sensitization to grass (−0.6%; 95% CI, −2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts.
Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.
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DOI: 10.1016/j.jaci.2015.09.037
PubMed: 26586040
PubMed Central: 4889785
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Corsico</name><affiliation wicri:level="1"><nlm:aff id="aff9">Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation–University of Pavia, Pavia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation–University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="De Marco, Roberto" sort="De Marco, Roberto" uniqKey="De Marco R" first="Roberto" last="De Marco">Roberto De Marco</name><affiliation wicri:level="1"><nlm:aff id="aff10">Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona</wicri:regionArea></affiliation></author><author><name sortKey="Demoly, Pascal" sort="Demoly, Pascal" uniqKey="Demoly P" first="Pascal" last="Demoly">Pascal Demoly</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Pulmonology, Division of Allergy, Arnaud de Villeneuve Hospital, CHU Montpellier, and EPAR Team–UMR-S 1136 INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pulmonology, Division of Allergy, Arnaud de Villeneuve Hospital, CHU Montpellier, and EPAR Team–UMR-S 1136 INSERM, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Forsberg, Bertil" sort="Forsberg, Bertil" uniqKey="Forsberg B" first="Bertil" last="Forsberg">Bertil Forsberg</name><affiliation wicri:level="1"><nlm:aff id="aff12">Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Gislason, Thorarinn" sort="Gislason, Thorarinn" uniqKey="Gislason T" first="Thorarinn" last="Gislason">Thorarinn Gislason</name><affiliation wicri:level="1"><nlm:aff id="aff13">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Respiratory Medicine and Sleep, Landspitali–The National University Hospital of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Respiratory Medicine and Sleep, Landspitali–The National University Hospital of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation wicri:level="1"><nlm:aff id="aff15">Institute of Epidemiology I, Helmholtz Zentrum, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum, Munich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16">Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Huerta, Ismael" sort="Huerta, Ismael" uniqKey="Huerta I" first="Ismael" last="Huerta">Ismael Huerta</name><affiliation wicri:level="1"><nlm:aff id="aff17">Epidemiological Surveillance Section, Directorate General of Public Health, Department of Health of Asturias, Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Epidemiological Surveillance Section, Directorate General of Public Health, Department of Health of Asturias, Oviedo</wicri:regionArea></affiliation></author><author><name sortKey="Janson, Christer" sort="Janson, Christer" uniqKey="Janson C" first="Christer" last="Janson">Christer Janson</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="J Gi, Rain" sort="J Gi, Rain" uniqKey="J Gi R" first="Rain" last="J Gi">Rain J Gi</name><affiliation wicri:level="1"><nlm:aff id="aff19">Tartu University Hospital, Lung Clinic, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Tartu University Hospital, Lung Clinic, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Jeong Lim" sort="Kim, Jeong Lim" uniqKey="Kim J" first="Jeong-Lim" last="Kim">Jeong-Lim Kim</name><affiliation wicri:level="1"><nlm:aff id="aff20">Department of Publich Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Publich Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Maldonado, Jose" sort="Maldonado, Jose" uniqKey="Maldonado J" first="José" last="Maldonado">José Maldonado</name><affiliation wicri:level="1"><nlm:aff id="aff21">Unit of Clinical Management of Pneumology and Allergy, University Hospital of Huelva, Huelva, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Clinical Management of Pneumology and Allergy, University Hospital of Huelva, Huelva</wicri:regionArea></affiliation></author><author><name sortKey="Martinez Moratalla Rovira, Jesus" sort="Martinez Moratalla Rovira, Jesus" uniqKey="Martinez Moratalla Rovira J" first="Jesús" last="Martinez-Moratalla Rovira">Jesús Martinez-Moratalla Rovira</name><affiliation wicri:level="1"><nlm:aff id="aff22">Unit of Pneumology, University Hospital of Albacete, Albacete, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Pneumology, University Hospital of Albacete, Albacete</wicri:regionArea></affiliation></author><author><name sortKey="Neukirch, Catherine" sort="Neukirch, Catherine" uniqKey="Neukirch C" first="Catherine" last="Neukirch">Catherine Neukirch</name><affiliation wicri:level="1"><nlm:aff id="aff23">INSERM UMR1152, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1152, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24">Université Paris Diderot Paris 7, UMR1152, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot Paris 7, UMR1152, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Nowak, Dennis" sort="Nowak, Dennis" uniqKey="Nowak D" first="Dennis" last="Nowak">Dennis Nowak</name><affiliation wicri:level="1"><nlm:aff id="aff25">Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, and the German Center for Lung Research, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, and the German Center for Lung Research, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name><affiliation wicri:level="1"><nlm:aff id="aff26">Pédiatrie, Pole Couple Enfants, CHU de Grenoble, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pédiatrie, Pole Couple Enfants, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27">INSERM U823, Institut Albert Bonniot, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U823, Institut Albert Bonniot, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff28">Université Joseph Fourier, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Probst Hensch, Nicole" sort="Probst Hensch, Nicole" uniqKey="Probst Hensch N" first="Nicole" last="Probst-Hensch">Nicole Probst-Hensch</name><affiliation wicri:level="1"><nlm:aff id="aff29">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff30">University of Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Raherison Semjen, Chantal" sort="Raherison Semjen, Chantal" uniqKey="Raherison Semjen C" first="Chantal" last="Raherison-Semjen">Chantal Raherison-Semjen</name><affiliation wicri:level="1"><nlm:aff id="aff31">INSERM U897, Institute of Public health and Epidemiology, Bordeaux University, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Institute of Public health and Epidemiology, Bordeaux University, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Svanes, Cecilie" sort="Svanes, Cecilie" uniqKey="Svanes C" first="Cecilie" last="Svanes">Cecilie Svanes</name><affiliation wicri:level="1"><nlm:aff id="aff32">Centre for International Health, University of Bergen, Bergen, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Centre for International Health, University of Bergen, Bergen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff33">Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Occupational Medicine, Haukeland University Hospital, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Urrutia Landa, Isabel" sort="Urrutia Landa, Isabel" uniqKey="Urrutia Landa I" first="Isabel" last="Urrutia Landa">Isabel Urrutia Landa</name><affiliation wicri:level="1"><nlm:aff id="aff34">Department of Pneumology, Galdakao Hospital, Galdakao, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, Galdakao Hospital, Galdakao</wicri:regionArea></affiliation></author><author><name sortKey="Van Ree, Ronald" sort="Van Ree, Ronald" uniqKey="Van Ree R" first="Ronald" last="Van Ree">Ronald Van Ree</name><affiliation wicri:level="1"><nlm:aff id="aff35">Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Versteeg, Serge A" sort="Versteeg, Serge A" uniqKey="Versteeg S" first="Serge A." last="Versteeg">Serge A. Versteeg</name><affiliation wicri:level="1"><nlm:aff id="aff36">Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Weyler, Joost" sort="Weyler, Joost" uniqKey="Weyler J" first="Joost" last="Weyler">Joost Weyler</name><affiliation wicri:level="1"><nlm:aff id="aff37">Epidemiology and Social Medicine and the StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Epidemiology and Social Medicine and the StatUA Statistics Centre, University of Antwerp, Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name><affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Pompeu Fabra (UPF), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Burney, Peter G J" sort="Burney, Peter G J" uniqKey="Burney P" first="Peter G. J." last="Burney">Peter G. J. Burney</name><affiliation wicri:level="1"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea></affiliation></author><author><name sortKey="Jarvis, Deborah L" sort="Jarvis, Deborah L" uniqKey="Jarvis D" first="Deborah L." last="Jarvis">Deborah L. Jarvis</name><affiliation wicri:level="1"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26586040</idno><idno type="pmc">4889785</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889785</idno><idno type="RBID">PMC:4889785</idno><idno type="doi">10.1016/j.jaci.2015.09.037</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002619</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002619</idno><idno type="wicri:Area/Pmc/Curation">002469</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002469</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Changes in IgE sensitization and total IgE levels over 20 years of follow-up</title><author><name sortKey="Amaral, Andre F S" sort="Amaral, Andre F S" uniqKey="Amaral A" first="André F. S." last="Amaral">André F. S. Amaral</name><affiliation wicri:level="1"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea></affiliation></author><author><name sortKey="Newson, Roger B" sort="Newson, Roger B" uniqKey="Newson R" first="Roger B." last="Newson">Roger B. Newson</name><affiliation wicri:level="1"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Primary Care and Public Health, School of Public Health, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Primary Care and Public Health, School of Public Health, Imperial College, London</wicri:regionArea></affiliation></author><author><name sortKey="Abramson, Michael J" sort="Abramson, Michael J" uniqKey="Abramson M" first="Michael J." last="Abramson">Michael J. Abramson</name><affiliation wicri:level="1"><nlm:aff id="aff3">School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Public Health & Preventive Medicine, Monash University, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Ant, Josep M" sort="Ant, Josep M" uniqKey="Ant J" first="Josep M." last="Ant">Josep M. Ant</name><affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>IMIM (Hospital del Mar Medical Research Institute), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Pompeu Fabra (UPF), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Bono, Roberto" sort="Bono, Roberto" uniqKey="Bono R" first="Roberto" last="Bono">Roberto Bono</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Public Health and Pediatrics, University of Turin, Turin, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health and Pediatrics, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Corsico, Angelo G" sort="Corsico, Angelo G" uniqKey="Corsico A" first="Angelo G." last="Corsico">Angelo G. Corsico</name><affiliation wicri:level="1"><nlm:aff id="aff9">Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation–University of Pavia, Pavia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation–University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="De Marco, Roberto" sort="De Marco, Roberto" uniqKey="De Marco R" first="Roberto" last="De Marco">Roberto De Marco</name><affiliation wicri:level="1"><nlm:aff id="aff10">Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona</wicri:regionArea></affiliation></author><author><name sortKey="Demoly, Pascal" sort="Demoly, Pascal" uniqKey="Demoly P" first="Pascal" last="Demoly">Pascal Demoly</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Pulmonology, Division of Allergy, Arnaud de Villeneuve Hospital, CHU Montpellier, and EPAR Team–UMR-S 1136 INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pulmonology, Division of Allergy, Arnaud de Villeneuve Hospital, CHU Montpellier, and EPAR Team–UMR-S 1136 INSERM, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Forsberg, Bertil" sort="Forsberg, Bertil" uniqKey="Forsberg B" first="Bertil" last="Forsberg">Bertil Forsberg</name><affiliation wicri:level="1"><nlm:aff id="aff12">Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Gislason, Thorarinn" sort="Gislason, Thorarinn" uniqKey="Gislason T" first="Thorarinn" last="Gislason">Thorarinn Gislason</name><affiliation wicri:level="1"><nlm:aff id="aff13">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Respiratory Medicine and Sleep, Landspitali–The National University Hospital of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Respiratory Medicine and Sleep, Landspitali–The National University Hospital of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation wicri:level="1"><nlm:aff id="aff15">Institute of Epidemiology I, Helmholtz Zentrum, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum, Munich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16">Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Huerta, Ismael" sort="Huerta, Ismael" uniqKey="Huerta I" first="Ismael" last="Huerta">Ismael Huerta</name><affiliation wicri:level="1"><nlm:aff id="aff17">Epidemiological Surveillance Section, Directorate General of Public Health, Department of Health of Asturias, Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Epidemiological Surveillance Section, Directorate General of Public Health, Department of Health of Asturias, Oviedo</wicri:regionArea></affiliation></author><author><name sortKey="Janson, Christer" sort="Janson, Christer" uniqKey="Janson C" first="Christer" last="Janson">Christer Janson</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="J Gi, Rain" sort="J Gi, Rain" uniqKey="J Gi R" first="Rain" last="J Gi">Rain J Gi</name><affiliation wicri:level="1"><nlm:aff id="aff19">Tartu University Hospital, Lung Clinic, Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Tartu University Hospital, Lung Clinic, Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Jeong Lim" sort="Kim, Jeong Lim" uniqKey="Kim J" first="Jeong-Lim" last="Kim">Jeong-Lim Kim</name><affiliation wicri:level="1"><nlm:aff id="aff20">Department of Publich Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Publich Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Maldonado, Jose" sort="Maldonado, Jose" uniqKey="Maldonado J" first="José" last="Maldonado">José Maldonado</name><affiliation wicri:level="1"><nlm:aff id="aff21">Unit of Clinical Management of Pneumology and Allergy, University Hospital of Huelva, Huelva, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Clinical Management of Pneumology and Allergy, University Hospital of Huelva, Huelva</wicri:regionArea></affiliation></author><author><name sortKey="Martinez Moratalla Rovira, Jesus" sort="Martinez Moratalla Rovira, Jesus" uniqKey="Martinez Moratalla Rovira J" first="Jesús" last="Martinez-Moratalla Rovira">Jesús Martinez-Moratalla Rovira</name><affiliation wicri:level="1"><nlm:aff id="aff22">Unit of Pneumology, University Hospital of Albacete, Albacete, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Pneumology, University Hospital of Albacete, Albacete</wicri:regionArea></affiliation></author><author><name sortKey="Neukirch, Catherine" sort="Neukirch, Catherine" uniqKey="Neukirch C" first="Catherine" last="Neukirch">Catherine Neukirch</name><affiliation wicri:level="1"><nlm:aff id="aff23">INSERM UMR1152, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1152, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24">Université Paris Diderot Paris 7, UMR1152, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot Paris 7, UMR1152, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Nowak, Dennis" sort="Nowak, Dennis" uniqKey="Nowak D" first="Dennis" last="Nowak">Dennis Nowak</name><affiliation wicri:level="1"><nlm:aff id="aff25">Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, and the German Center for Lung Research, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, and the German Center for Lung Research, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name><affiliation wicri:level="1"><nlm:aff id="aff26">Pédiatrie, Pole Couple Enfants, CHU de Grenoble, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pédiatrie, Pole Couple Enfants, CHU de Grenoble, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27">INSERM U823, Institut Albert Bonniot, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U823, Institut Albert Bonniot, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff28">Université Joseph Fourier, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Probst Hensch, Nicole" sort="Probst Hensch, Nicole" uniqKey="Probst Hensch N" first="Nicole" last="Probst-Hensch">Nicole Probst-Hensch</name><affiliation wicri:level="1"><nlm:aff id="aff29">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff30">University of Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Raherison Semjen, Chantal" sort="Raherison Semjen, Chantal" uniqKey="Raherison Semjen C" first="Chantal" last="Raherison-Semjen">Chantal Raherison-Semjen</name><affiliation wicri:level="1"><nlm:aff id="aff31">INSERM U897, Institute of Public health and Epidemiology, Bordeaux University, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U897, Institute of Public health and Epidemiology, Bordeaux University, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Svanes, Cecilie" sort="Svanes, Cecilie" uniqKey="Svanes C" first="Cecilie" last="Svanes">Cecilie Svanes</name><affiliation wicri:level="1"><nlm:aff id="aff32">Centre for International Health, University of Bergen, Bergen, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Centre for International Health, University of Bergen, Bergen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff33">Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Occupational Medicine, Haukeland University Hospital, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Urrutia Landa, Isabel" sort="Urrutia Landa, Isabel" uniqKey="Urrutia Landa I" first="Isabel" last="Urrutia Landa">Isabel Urrutia Landa</name><affiliation wicri:level="1"><nlm:aff id="aff34">Department of Pneumology, Galdakao Hospital, Galdakao, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, Galdakao Hospital, Galdakao</wicri:regionArea></affiliation></author><author><name sortKey="Van Ree, Ronald" sort="Van Ree, Ronald" uniqKey="Van Ree R" first="Ronald" last="Van Ree">Ronald Van Ree</name><affiliation wicri:level="1"><nlm:aff id="aff35">Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Versteeg, Serge A" sort="Versteeg, Serge A" uniqKey="Versteeg S" first="Serge A." last="Versteeg">Serge A. Versteeg</name><affiliation wicri:level="1"><nlm:aff id="aff36">Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Weyler, Joost" sort="Weyler, Joost" uniqKey="Weyler J" first="Joost" last="Weyler">Joost Weyler</name><affiliation wicri:level="1"><nlm:aff id="aff37">Epidemiology and Social Medicine and the StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Epidemiology and Social Medicine and the StatUA Statistics Centre, University of Antwerp, Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name><affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Pompeu Fabra (UPF), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Burney, Peter G J" sort="Burney, Peter G J" uniqKey="Burney P" first="Peter G. J." last="Burney">Peter G. J. Burney</name><affiliation wicri:level="1"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea></affiliation></author><author><name sortKey="Jarvis, Deborah L" sort="Jarvis, Deborah L" uniqKey="Jarvis D" first="Deborah L." last="Jarvis">Deborah L. Jarvis</name><affiliation wicri:level="1"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of Allergy and Clinical Immunology</title><idno type="ISSN">0091-6749</idno><idno type="eISSN">1097-6825</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect.</p></sec><sec><title>Objective</title><p>We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period.</p></sec><sec><title>Methods</title><p>Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse.</p></sec><sec><title>Results</title><p>Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (−4.6%; 95% CI, −7.0% to −2.1%). The prevalence of sensitization to house dust mite (−4.3%; 95% CI, −6.0% to −2.6%) and cat (−2.1%; 95% CI, −3.6% to −0.7%) decreased more than sensitization to grass (−0.6%; 95% CI, −2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts.</p></sec><sec><title>Conclusion</title><p>Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Salo, P M" uniqKey="Salo P">P.M. Salo</name></author><author><name sortKey="Arbes, S J" uniqKey="Arbes S">S.J. Arbes</name></author><author><name sortKey="Jaramillo, R" uniqKey="Jaramillo R">R. Jaramillo</name></author><author><name sortKey="Calatroni, A" uniqKey="Calatroni A">A. Calatroni</name></author><author><name sortKey="Weir, C H" uniqKey="Weir C">C.H. Weir</name></author><author><name sortKey="Sever, M L" uniqKey="Sever M">M.L. Sever</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broadfield, E" uniqKey="Broadfield E">E. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Allergy Clin Immunol</journal-id><journal-id journal-id-type="iso-abbrev">J. Allergy Clin. Immunol</journal-id><journal-title-group><journal-title>The Journal of Allergy and Clinical Immunology</journal-title></journal-title-group><issn pub-type="ppub">0091-6749</issn><issn pub-type="epub">1097-6825</issn><publisher><publisher-name>Mosby</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26586040</article-id><article-id pub-id-type="pmc">4889785</article-id><article-id pub-id-type="publisher-id">S0091-6749(15)01430-X</article-id><article-id pub-id-type="doi">10.1016/j.jaci.2015.09.037</article-id><article-categories><subj-group subj-group-type="heading"><subject>Mechanisms of Allergy and Clinical Immunology</subject></subj-group></article-categories><title-group><article-title>Changes in IgE sensitization and total IgE levels over 20 years of follow-up</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Amaral</surname><given-names>André F.S.</given-names></name><degrees>PhD</degrees><email>a.amaral@imperial.ac.uk</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author"><name><surname>Newson</surname><given-names>Roger B.</given-names></name><degrees>DPhil</degrees><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Abramson</surname><given-names>Michael J.</given-names></name><degrees>PhD</degrees><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Antó</surname><given-names>Josep M.</given-names></name><degrees>PhD</degrees><xref rid="aff4" ref-type="aff">d</xref><xref rid="aff5" ref-type="aff">e</xref><xref rid="aff6" ref-type="aff">f</xref><xref rid="aff7" ref-type="aff">g</xref></contrib><contrib contrib-type="author"><name><surname>Bono</surname><given-names>Roberto</given-names></name><degrees>PhD</degrees><xref rid="aff8" ref-type="aff">h</xref></contrib><contrib contrib-type="author"><name><surname>Corsico</surname><given-names>Angelo G.</given-names></name><degrees>PhD</degrees><xref rid="aff9" ref-type="aff">i</xref></contrib><contrib contrib-type="author"><name><surname>de Marco</surname><given-names>Roberto</given-names></name><degrees>PhD</degrees><xref rid="aff10" ref-type="aff">j</xref></contrib><contrib contrib-type="author"><name><surname>Demoly</surname><given-names>Pascal</given-names></name><degrees>MD</degrees><xref rid="aff11" ref-type="aff">k</xref></contrib><contrib contrib-type="author"><name><surname>Forsberg</surname><given-names>Bertil</given-names></name><degrees>PhD</degrees><xref rid="aff12" ref-type="aff">l</xref></contrib><contrib contrib-type="author"><name><surname>Gislason</surname><given-names>Thorarinn</given-names></name><degrees>PhD</degrees><xref rid="aff13" ref-type="aff">m</xref><xref rid="aff14" ref-type="aff">n</xref></contrib><contrib contrib-type="author"><name><surname>Heinrich</surname><given-names>Joachim</given-names></name><degrees>PhD</degrees><xref rid="aff15" ref-type="aff">o</xref><xref rid="aff16" ref-type="aff">p</xref></contrib><contrib contrib-type="author"><name><surname>Huerta</surname><given-names>Ismael</given-names></name><degrees>MD</degrees><xref rid="aff17" ref-type="aff">q</xref></contrib><contrib contrib-type="author"><name><surname>Janson</surname><given-names>Christer</given-names></name><degrees>PhD</degrees><xref rid="aff18" ref-type="aff">r</xref></contrib><contrib contrib-type="author"><name><surname>Jõgi</surname><given-names>Rain</given-names></name><degrees>PhD</degrees><xref rid="aff19" ref-type="aff">s</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Jeong-Lim</given-names></name><degrees>PhD</degrees><xref rid="aff20" ref-type="aff">t</xref></contrib><contrib contrib-type="author"><name><surname>Maldonado</surname><given-names>José</given-names></name><degrees>MD</degrees><xref rid="aff21" ref-type="aff">u</xref></contrib><contrib contrib-type="author"><name><surname>Martinez-Moratalla Rovira</surname><given-names>Jesús</given-names></name><degrees>MD</degrees><xref rid="aff22" ref-type="aff">v</xref></contrib><contrib contrib-type="author"><name><surname>Neukirch</surname><given-names>Catherine</given-names></name><degrees>MD</degrees><xref rid="aff23" ref-type="aff">w</xref><xref rid="aff24" ref-type="aff">x</xref></contrib><contrib contrib-type="author"><name><surname>Nowak</surname><given-names>Dennis</given-names></name><degrees>MD</degrees><xref rid="aff25" ref-type="aff">y</xref></contrib><contrib contrib-type="author"><name><surname>Pin</surname><given-names>Isabelle</given-names></name><degrees>MD</degrees><xref rid="aff26" ref-type="aff">z</xref><xref rid="aff27" ref-type="aff">aa</xref><xref rid="aff28" ref-type="aff">bb</xref></contrib><contrib contrib-type="author"><name><surname>Probst-Hensch</surname><given-names>Nicole</given-names></name><degrees>PhD</degrees><xref rid="aff29" ref-type="aff">cc</xref><xref rid="aff30" ref-type="aff">dd</xref></contrib><contrib contrib-type="author"><name><surname>Raherison-Semjen</surname><given-names>Chantal</given-names></name><degrees>PhD</degrees><xref rid="aff31" ref-type="aff">ee</xref></contrib><contrib contrib-type="author"><name><surname>Svanes</surname><given-names>Cecilie</given-names></name><degrees>PhD</degrees><xref rid="aff32" ref-type="aff">ff</xref><xref rid="aff33" ref-type="aff">gg</xref></contrib><contrib contrib-type="author"><name><surname>Urrutia Landa</surname><given-names>Isabel</given-names></name><degrees>PhD</degrees><xref rid="aff34" ref-type="aff">hh</xref></contrib><contrib contrib-type="author"><name><surname>van Ree</surname><given-names>Ronald</given-names></name><degrees>PhD</degrees><xref rid="aff35" ref-type="aff">ii</xref></contrib><contrib contrib-type="author"><name><surname>Versteeg</surname><given-names>Serge A.</given-names></name><degrees>BSc</degrees><xref rid="aff36" ref-type="aff">jj</xref></contrib><contrib contrib-type="author"><name><surname>Weyler</surname><given-names>Joost</given-names></name><degrees>PhD</degrees><xref rid="aff37" ref-type="aff">kk</xref></contrib><contrib contrib-type="author"><name><surname>Zock</surname><given-names>Jan-Paul</given-names></name><degrees>PhD</degrees><xref rid="aff4" ref-type="aff">d</xref><xref rid="aff6" ref-type="aff">f</xref><xref rid="aff7" ref-type="aff">g</xref></contrib><contrib contrib-type="author"><name><surname>Burney</surname><given-names>Peter G.J.</given-names></name><degrees>MD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Jarvis</surname><given-names>Deborah L.</given-names></name><degrees>MD</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</aff><aff id="aff2"><label>b</label>Department of Primary Care and Public Health, School of Public Health, Imperial College, London, United Kingdom</aff><aff id="aff3"><label>c</label>School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia</aff><aff id="aff4"><label>d</label>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</aff><aff id="aff5"><label>e</label>IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain</aff><aff id="aff6"><label>f</label>Universitat Pompeu Fabra (UPF), Barcelona, Spain</aff><aff id="aff7"><label>g</label>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain</aff><aff id="aff8"><label>h</label>Department of Public Health and Pediatrics, University of Turin, Turin, Italy</aff><aff id="aff9"><label>i</label>Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation–University of Pavia, Pavia, Italy</aff><aff id="aff10"><label>j</label>Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona, Italy</aff><aff id="aff11"><label>k</label>Department of Pulmonology, Division of Allergy, Arnaud de Villeneuve Hospital, CHU Montpellier, and EPAR Team–UMR-S 1136 INSERM, Paris, France</aff><aff id="aff12"><label>l</label>Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden</aff><aff id="aff13"><label>m</label>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="aff14"><label>n</label>Department of Respiratory Medicine and Sleep, Landspitali–The National University Hospital of Iceland, Reykjavik, Iceland</aff><aff id="aff15"><label>o</label>Institute of Epidemiology I, Helmholtz Zentrum, Munich, Germany</aff><aff id="aff16"><label>p</label>Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, Munich, Germany</aff><aff id="aff17"><label>q</label>Epidemiological Surveillance Section, Directorate General of Public Health, Department of Health of Asturias, Oviedo, Spain</aff><aff id="aff18"><label>r</label>Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden</aff><aff id="aff19"><label>s</label>Tartu University Hospital, Lung Clinic, Tartu, Estonia</aff><aff id="aff20"><label>t</label>Department of Publich Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</aff><aff id="aff21"><label>u</label>Unit of Clinical Management of Pneumology and Allergy, University Hospital of Huelva, Huelva, Spain</aff><aff id="aff22"><label>v</label>Unit of Pneumology, University Hospital of Albacete, Albacete, Spain</aff><aff id="aff23"><label>w</label>INSERM UMR1152, Paris, France</aff><aff id="aff24"><label>x</label>Université Paris Diderot Paris 7, UMR1152, Paris, France</aff><aff id="aff25"><label>y</label>Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, and the German Center for Lung Research, Munich, Germany</aff><aff id="aff26"><label>z</label>Pédiatrie, Pole Couple Enfants, CHU de Grenoble, Grenoble, France</aff><aff id="aff27"><label>aa</label>INSERM U823, Institut Albert Bonniot, Grenoble, France</aff><aff id="aff28"><label>bb</label>Université Joseph Fourier, Grenoble, France</aff><aff id="aff29"><label>cc</label>Swiss Tropical and Public Health Institute, Basel, Switzerland</aff><aff id="aff30"><label>dd</label>University of Basel, Basel, Switzerland</aff><aff id="aff31"><label>ee</label>INSERM U897, Institute of Public health and Epidemiology, Bordeaux University, Bordeaux, France</aff><aff id="aff32"><label>ff</label>Centre for International Health, University of Bergen, Bergen, Norway</aff><aff id="aff33"><label>gg</label>Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway</aff><aff id="aff34"><label>hh</label>Department of Pneumology, Galdakao Hospital, Galdakao, Spain</aff><aff id="aff35"><label>ii</label>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</aff><aff id="aff36"><label>jj</label>Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</aff><aff id="aff37"><label>kk</label>Epidemiology and Social Medicine and the StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author: André F. S. Amaral, PhD, Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, 1B Manresa Rd, London SW3 6LR, United Kingdom. <email>a.amaral@imperial.ac.uk</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>6</month><year>2016</year></pub-date><volume>137</volume><issue>6</issue><fpage>1788</fpage><lpage>1795.e9</lpage><history><date date-type="received"><day>10</day><month>4</month><year>2015</year></date><date date-type="rev-recd"><day>21</day><month>8</month><year>2015</year></date><date date-type="accepted"><day>30</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 The Authors</copyright-statement><copyright-year>2015</copyright-year><license license-type="CC BY" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).</license-p></license></permissions><abstract id="abs0010"><sec><title>Background</title><p>Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect.</p></sec><sec><title>Objective</title><p>We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period.</p></sec><sec><title>Methods</title><p>Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse.</p></sec><sec><title>Results</title><p>Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (−4.6%; 95% CI, −7.0% to −2.1%). The prevalence of sensitization to house dust mite (−4.3%; 95% CI, −6.0% to −2.6%) and cat (−2.1%; 95% CI, −3.6% to −0.7%) decreased more than sensitization to grass (−0.6%; 95% CI, −2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts.</p></sec><sec><title>Conclusion</title><p>Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.</p></sec></abstract><kwd-group id="kwrds0010"><title>Key words</title><kwd>Allergens</kwd><kwd>sensitization</kwd><kwd>cohort study</kwd><kwd>epidemiology</kwd><kwd>IgE</kwd><kwd>longitudinal analysis</kwd><kwd>aging</kwd><kwd>immunosenescence</kwd></kwd-group><kwd-group id="kwrds0015"><title>Abbreviations used</title><kwd>ECRHS, European Community Respiratory Health Survey</kwd><kwd>GM, Geometric mean</kwd></kwd-group></article-meta></front><floats-group><fig id="fig1"><label>Fig 1</label><caption><p>Participant flow in the ECRHS. Only centers that took part in all 3 surveys are included.</p></caption><graphic xlink:href="gr1"></graphic></fig><fig id="fig2"><label>Fig 2</label><caption><p>Net change in prevalence of IgE sensitization (cutoff, 0.35 kU<sub>A</sub>/L) to house dust mite (<italic>I</italic><sup><italic>2</italic></sup> [heterogeneity] = 0.0%, <italic>P</italic> = .71), grass (<italic>I</italic><sup><italic>2</italic></sup> = 44.9%, <italic>P</italic> = .009), cat (<italic>I</italic><sup><italic>2</italic></sup> = 29.0%, <italic>P</italic> = .09), and at least 1 of these allergens (<italic>I</italic><sup><italic>2</italic></sup> = 38.6%, <italic>P</italic> = .03). Centers are sorted by latitude (from north to south).</p></caption><graphic xlink:href="gr2"></graphic></fig><fig id="fig3"><label>Fig 3</label><caption><p>Prevalence of IgE sensitization to house dust mite <bold>(A)</bold>, grass <bold>(B)</bold>, cat <bold>(C)</bold>, and at least 1 of these 3 allergens <bold>(D)</bold> over 20 years of follow-up by year-of-birth cohort.</p></caption><graphic xlink:href="gr3"></graphic></fig><fig id="fig4"><label>Fig 4</label><caption><p>Changes in total IgE levels (kilounits per liter) over 20 years of follow-up by year-of-birth cohort.</p></caption><graphic xlink:href="gr4"></graphic></fig><table-wrap id="tbl1" position="float"><label>Table I</label><caption><p>Net change in IgE sensitization to house dust mite, grass, and cat and total IgE levels over 20 years (n = 3206)</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th>Prevalence<break></break>(%), ECRHS I</th><th>Net change (95% CI), ECRHS II vs I</th><th><italic>P</italic> value for heterogeneity<break></break>between centers</th><th>Net change (95% CI), ECRHS III vs I</th><th><italic>P</italic> value for heterogeneity between centers</th></tr></thead><tbody><tr><td>House dust mite</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> >0.35 kU<sub>A</sub>/L</td><td align="char">16.6</td><td align="char">−0.7 (−2.2 to 0.9)</td><td align="char">.051</td><td align="char">−4.3 (−6.0 to −2.6)</td><td align="char">.71</td></tr><tr><td> >0.70 kU<sub>A</sub>/L</td><td align="char">13.1</td><td align="char">−0.7 (−1.9 to 0.4)</td><td align="char">.63</td><td align="char">−3.1 (−4.5 to −1.7)</td><td align="char">.21</td></tr><tr><td>Grass</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> >0.35 kU<sub>A</sub>/L</td><td align="char">17.0</td><td align="char">0.5 (−1.0 to 2.0)</td><td align="char">.048</td><td align="char">−0.6 (−2.5 to 1.3)</td><td align="char">.009</td></tr><tr><td> >0.70 kU<sub>A</sub>/L</td><td align="char">14.2</td><td align="char">0.0 (−1.3 to 1.3)</td><td align="char">.48</td><td align="char">−2.2 (−3.8 to −0.6)</td><td align="char">.97</td></tr><tr><td>Cat</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> >0.35 kU<sub>A</sub>/L</td><td align="char">8.8</td><td align="char">−0.9 (−2.1 to 0.3)</td><td align="char">.14</td><td align="char">−2.1 (−3.6 to −0.7)</td><td align="char">.09</td></tr><tr><td> >0.70 kU<sub>A</sub>/L</td><td align="char">6.4</td><td align="char">0.0 (−1.0 to 1.1)</td><td align="char">.15</td><td align="char">−1.1 (−2.2 to 0.1)</td><td align="char">.04</td></tr><tr><td>House dust mite, grass, or cat</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> >0.35 kU<sub>A</sub>/L</td><td align="char">29.4</td><td align="char">0.1 (−2.0 to 2.1)</td><td align="char">.003</td><td align="char">−4.6 (−7.0 to −2.1)</td><td align="char">.03</td></tr><tr><td> >0.70 kU<sub>A</sub>/L</td><td align="char">24.2</td><td align="char">−0.6 (−2.2 to 1.0)</td><td align="char">.11</td><td align="char">−4.6 (−6.6 to −2.6)</td><td align="char">.17</td></tr></tbody></table><table frame="hsides" rules="groups"><thead><tr><th></th><th>GM, ECRHS I</th><th>GM ratio (95% CI), ECRHS II vs I</th><th><italic>P</italic> value for heterogeneity<break></break>between centers</th><th>GM ratio (95% CI), ECRHS III vs I</th><th><italic>P</italic> value for heterogeneity between centers</th></tr></thead><tbody><tr><td>Total IgE (kU/L)</td><td align="char">29.8</td><td align="char">0.84 (0.78 to 0.90)</td><td align="char"><.001</td><td align="char">0.63 (0.58 to 0.68)</td><td align="char"><.001</td></tr></tbody></table></table-wrap><table-wrap id="tbl2" position="float"><label>Table II</label><caption><p>Net change in IgE sensitization (>0.35 kU<sub>A</sub>/L) to house dust mite, grass, and cat and total IgE levels (kilounits per liter) over 20 years by year-of-birth cohort</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th colspan="3">1964-1973 (n = 736)<hr></hr></th><th colspan="3">1954-1963 (n = 1314)<hr></hr></th><th colspan="3">1944-1953 (n = 1156)<hr></hr></th></tr><tr><th>Prevalence (%) or GM<hr></hr></th><th colspan="2">Net change (95% CI)<hr></hr></th><th>Prevalence (%) or GM<hr></hr></th><th colspan="2">Net change (95% CI)<hr></hr></th><th>Prevalence (%) or GM<hr></hr></th><th colspan="2">Net change (95% CI)<hr></hr></th></tr><tr><th>ECRHS I</th><th>ECRHS II vs I</th><th>ECRHS III vs I</th><th>ECRHS I</th><th>ECRHS II vs I</th><th>ECRHS III vs I</th><th>ECRHS I</th><th>ECRHS II vs I</th><th>ECRHS III vs I</th></tr></thead><tbody><tr><td>House dust mite</td><td align="char">18.6</td><td align="char">−0.6 (−3.0 to 1.8)</td><td align="char">−4.1 (−6.7 to −1.5)</td><td align="char">17.2</td><td align="char">0.2 (−1.9 to 2.4)</td><td align="char">−4.5 (−6.9 to −2.1)</td><td align="char">13.8</td><td align="char">−2.0 (−3.9 to −0.1)</td><td align="char">−4.3 (−6.6 to −1.9)</td></tr><tr><td>Grass</td><td align="char">20.6</td><td align="char">3.3 (0.4 to 6.2)</td><td align="char">1.5 (−1.8 to 4.9)</td><td align="char">15.9</td><td align="char">0.5 (−1.4 to 2.3)</td><td align="char">−0.1 (−2.5 to 2.3)</td><td align="char">15.4</td><td align="char">−1.9 (−3.8 to 0.0)</td><td align="char">−3.2 (−5.3 to −1.0)</td></tr><tr><td>Cat</td><td align="char">10.5</td><td align="char">0.2 (−2.2 to 2.6)</td><td align="char">−0.7 (−3.5 to 2.0)</td><td align="char">8.3</td><td align="char">−1.4 (−2.9 to 0.1)</td><td align="char">−2.0 (−3.6 to −0.3)</td><td align="char">8.1</td><td align="char">−1.2 (−2.7 to 0.2)</td><td align="char">−3.6 (−5.2 to −2.0)</td></tr><tr><td>House dust mite, grass, or cat</td><td align="char">33.5</td><td align="char">1.9 (−1.3 to 5.1)</td><td align="char">−2.1 (−6.1 to 1.9)</td><td align="char">28.7</td><td align="char">1.1 (−1.6 to 3.7)</td><td align="char">−4.1 (−7.2 to −1.1)</td><td align="char">26.5</td><td align="char">−3.0 (−5.6 to −0.3)</td><td align="char">−7.4 (−10.4 to −4.3)</td></tr><tr><td>Total IgE</td><td align="char">29.9</td><td align="char">0.81 (0.72 to 0.91)</td><td align="char">0.61 (0.54 to 0.68)</td><td align="char">31.3</td><td align="char">0.85 (0.78 to 0.92)</td><td align="char">0.61 (0.56 to 0.67)</td><td align="char">27.9</td><td align="char">0.84 (0.78 to 0.92)</td><td align="char">0.68 (0.61 to 0.75)</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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