Role of hepatic intra-arterial therapies in metastatic neuroendocrine tumours (NET): guidelines from the NET-Liver-Metastases Consensus Conference
Identifieur interne : 002418 ( Pmc/Curation ); précédent : 002417; suivant : 002419Role of hepatic intra-arterial therapies in metastatic neuroendocrine tumours (NET): guidelines from the NET-Liver-Metastases Consensus Conference
Auteurs : Andrew Kennedy [États-Unis] ; Lourens Bester [Australie] ; Riad Salem [États-Unis] ; Ricky A. Sharma [Royaume-Uni] ; Rowan W. Parks [Royaume-Uni] ; Philippe Ruszniewski [France]Source :
- HPB : The Official Journal of the International Hepato Pancreato Biliary Association [ 1365-182X ] ; 2014.
Abstract
Liver metastasis from a neuroendocrine tumour (NET) represents a significant clinical entity. A multidisciplinary group of experts was convened to develop state-of-the-art recommendations for its management.
Peer-reviewed published reports on intra-arterial therapies for NET hepatic metastases were reviewed and the findings presented to a jury of peers. The therapies reviewed included transarterial embolization (TAE), transarterial chemoembolization (TACE) and radioembolization (RE). Two systems were used to evaluate the level of evidence in each publication: (i) the US National Cancer Institute (NCI) system, and (ii) the GRADE system.
Eighteen publications were reviewed. These comprised 11 reports on TAE or TACE and seven on RE. Four questions posed to the panel were answered and recommendations offered.
Studies of moderate quality support the use of TAE, TACE and RE in hepatic metastases of NETs. The quality and strength of the reports available do not allow any modality to be determined as superior in terms of imaging response, symptomatic response or impact on survival. Radioembolization may have advantages over TAE and TACE because it causes fewer side-effects and requires fewer treatments. Based on current European Neuroendocrine Tumor Society (ENETS) Consensus Guidelines, RE can be substituted for TAE or TACE in patients with either liver-only disease or those with limited extrahepatic metastases.
Url:
DOI: 10.1111/hpb.12326
PubMed: 25186181
PubMed Central: 4266438
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<author><name sortKey="Salem, Riad" sort="Salem, Riad" uniqKey="Salem R" first="Riad" last="Salem">Riad Salem</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Objectives</title>
<p>Liver metastasis from a neuroendocrine tumour (NET) represents a significant clinical entity. A multidisciplinary group of experts was convened to develop state-of-the-art recommendations for its management.</p>
</sec>
<sec><title>Methods</title>
<p>Peer-reviewed published reports on intra-arterial therapies for NET hepatic metastases were reviewed and the findings presented to a jury of peers. The therapies reviewed included transarterial embolization (TAE), transarterial chemoembolization (TACE) and radioembolization (RE). Two systems were used to evaluate the level of evidence in each publication: (i) the US National Cancer Institute (NCI) system, and (ii) the GRADE system.</p>
</sec>
<sec><title>Results</title>
<p>Eighteen publications were reviewed. These comprised 11 reports on TAE or TACE and seven on RE. Four questions posed to the panel were answered and recommendations offered.</p>
</sec>
<sec><title>Conclusions</title>
<p>Studies of moderate quality support the use of TAE, TACE and RE in hepatic metastases of NETs. The quality and strength of the reports available do not allow any modality to be determined as superior in terms of imaging response, symptomatic response or impact on survival. Radioembolization may have advantages over TAE and TACE because it causes fewer side-effects and requires fewer treatments. Based on current European Neuroendocrine Tumor Society (ENETS) Consensus Guidelines, RE can be substituted for TAE or TACE in patients with either liver-only disease or those with limited extrahepatic metastases.</p>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">HPB (Oxford)</journal-id>
<journal-id journal-id-type="iso-abbrev">HPB (Oxford)</journal-id>
<journal-id journal-id-type="publisher-id">hpb</journal-id>
<journal-title-group><journal-title>HPB : The Official Journal of the International Hepato Pancreato Biliary Association</journal-title>
</journal-title-group>
<issn pub-type="ppub">1365-182X</issn>
<issn pub-type="epub">1477-2574</issn>
<publisher><publisher-name>BlackWell Publishing Ltd</publisher-name>
<publisher-loc>Oxford, UK</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25186181</article-id>
<article-id pub-id-type="pmc">4266438</article-id>
<article-id pub-id-type="doi">10.1111/hpb.12326</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Role of hepatic intra-arterial therapies in metastatic neuroendocrine tumours (NET): guidelines from the NET-Liver-Metastases Consensus Conference</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kennedy</surname>
<given-names>Andrew</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bester</surname>
<given-names>Lourens</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Salem</surname>
<given-names>Riad</given-names>
</name>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sharma</surname>
<given-names>Ricky A</given-names>
</name>
<xref ref-type="aff" rid="au4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Parks</surname>
<given-names>Rowan W</given-names>
</name>
<xref ref-type="aff" rid="au5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ruszniewski</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="au6">6</xref>
</contrib>
<aff id="au1"><label>1</label>
<institution>Radiation Oncology Research, Sarah Cannon Research Institute</institution>
<addr-line>Nashville, TN, USA</addr-line>
</aff>
<aff id="au2"><label>2</label>
<institution>Department of Radiology, St Vincent's Public Hospital</institution>
<addr-line>Sydney, NSW, Australia</addr-line>
</aff>
<aff id="au3"><label>3</label>
<institution>Department of Radiology, Northwestern University</institution>
<addr-line>Chicago, IL, USA</addr-line>
</aff>
<aff id="au4"><label>4</label>
<institution>Oncology Department, Gray Institute, University of Oxford, Churchill Hospital</institution>
<addr-line>Oxford, UK</addr-line>
</aff>
<aff id="au5"><label>5</label>
<institution>Department of Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh</institution>
<addr-line>Edinburgh, UK</addr-line>
</aff>
<aff id="au6"><label>6</label>
<institution>Centre for Gastroenterological and Pancreatic Disease, Beaujon Hospital, University of Paris Denis-Diderot</institution>
<addr-line>Paris, France</addr-line>
</aff>
</contrib-group>
<author-notes><corresp id="cor1"><bold>Correspondence</bold>
, Andrew S. Kennedy, Radiation Oncology Research, Sarah Cannon Research Institute, 3322 West End Avenue, Suite 800, Nashville, TN 37203, USA. Tel: + 1 615 524 4200. Fax: + 1 615 524 4700. E-mail: <email>andrew.kennedy@sarahcannon.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>04</day>
<month>9</month>
<year>2014</year>
</pub-date>
<volume>17</volume>
<issue>1</issue>
<fpage>29</fpage>
<lpage>37</lpage>
<history><date date-type="received"><day>14</day>
<month>4</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>09</day>
<month>7</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 The Authors. HPB published by John Wiley & Sons Ltd on behalf of the International Hepato-Pancreato-Biliary Association.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p>This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.</license-p>
</license>
</permissions>
<abstract><sec><title>Objectives</title>
<p>Liver metastasis from a neuroendocrine tumour (NET) represents a significant clinical entity. A multidisciplinary group of experts was convened to develop state-of-the-art recommendations for its management.</p>
</sec>
<sec><title>Methods</title>
<p>Peer-reviewed published reports on intra-arterial therapies for NET hepatic metastases were reviewed and the findings presented to a jury of peers. The therapies reviewed included transarterial embolization (TAE), transarterial chemoembolization (TACE) and radioembolization (RE). Two systems were used to evaluate the level of evidence in each publication: (i) the US National Cancer Institute (NCI) system, and (ii) the GRADE system.</p>
</sec>
<sec><title>Results</title>
<p>Eighteen publications were reviewed. These comprised 11 reports on TAE or TACE and seven on RE. Four questions posed to the panel were answered and recommendations offered.</p>
</sec>
<sec><title>Conclusions</title>
<p>Studies of moderate quality support the use of TAE, TACE and RE in hepatic metastases of NETs. The quality and strength of the reports available do not allow any modality to be determined as superior in terms of imaging response, symptomatic response or impact on survival. Radioembolization may have advantages over TAE and TACE because it causes fewer side-effects and requires fewer treatments. Based on current European Neuroendocrine Tumor Society (ENETS) Consensus Guidelines, RE can be substituted for TAE or TACE in patients with either liver-only disease or those with limited extrahepatic metastases.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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