A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis
Identifieur interne : 002368 ( Pmc/Curation ); précédent : 002367; suivant : 002369A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis
Auteurs : Stella Cesari [France, Australie] ; Maud Bernoux [Australie] ; Philippe Moncuquet [Australie] ; Thomas Kroj [France] ; Peter N. Dodds [Australie]Source :
- Frontiers in Plant Science [ 1664-462X ] ; 2014.
Abstract
Plant immunity is often triggered by the specific recognition of pathogen effectors by intracellular nucleotide-binding, leucine-rich repeat receptors (NLR). Plant NLRs contain an N-terminal signaling domain that is mostly represented by either a Toll-interleukin1 receptor (TIR) domain or a coiled coil (CC) domain. In many cases, single NLR proteins are sufficient for both effector recognition and signaling activation. However, many paired NLRs have now been identified where both proteins are required to confer resistance to pathogens. Recent detailed studies on the
Url:
DOI: 10.3389/fpls.2014.00606
PubMed: 25506347
PubMed Central: 4246468
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<series><title level="j">Frontiers in Plant Science</title>
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<front><div type="abstract" xml:lang="en"><p>Plant immunity is often triggered by the specific recognition of pathogen effectors by intracellular nucleotide-binding, leucine-rich repeat receptors (NLR). Plant NLRs contain an N-terminal signaling domain that is mostly represented by either a Toll-interleukin1 receptor (TIR) domain or a coiled coil (CC) domain. In many cases, single NLR proteins are sufficient for both effector recognition and signaling activation. However, many paired NLRs have now been identified where both proteins are required to confer resistance to pathogens. Recent detailed studies on the <italic>Arabidopsis thaliana</italic>
TIR-NLR pair RRS1 and RPS4 and on the rice CC-NLR pair RGA4 and RGA5 have revealed for the first time how such protein pairs function together. In both cases, the paired partners interact physically to form a hetero-complex receptor in which each partner plays distinct roles in effector recognition or signaling activation, highlighting a conserved mode of action of NLR pairs across both monocotyledonous and dicotyledonous plants. We also describe an “integrated decoy” model for the function of these receptor complexes. In this model, a plant protein targeted by an effector has been duplicated and fused to one member of the NLR pair, where it acts as a bait to trigger defense signaling by the second NLR upon effector binding. This mechanism may be common to many other plant NLR pairs.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Plant Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Plant Sci</journal-id>
<journal-id journal-id-type="publisher-id">Front. Plant Sci.</journal-id>
<journal-title-group><journal-title>Frontiers in Plant Science</journal-title>
</journal-title-group>
<issn pub-type="epub">1664-462X</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25506347</article-id>
<article-id pub-id-type="pmc">4246468</article-id>
<article-id pub-id-type="doi">10.3389/fpls.2014.00606</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Plant Science</subject>
<subj-group><subject>Hypothesis and Theory Article</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Cesari</surname>
<given-names>Stella</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/194053"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Bernoux</surname>
<given-names>Maud</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/189856"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Moncuquet</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kroj</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/179420"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Dodds</surname>
<given-names>Peter N.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn002"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/28215"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Institut National de la Recherche Agronomique, Unité Mixtes de Recherche Biology and Genetics of Plant-Pathogen Interactions</institution>
<country>Montpellier, France</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Unité Mixtes de Recherche Biology and Genetics of Plant-Pathogen Interactions</institution>
<country>Montpellier, France</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Agriculture Flagship, Commonwealth Scientific and Industrial Research Organisation</institution>
<country>Canberra, ACT, Australia</country>
</aff>
<aff id="aff4"><sup>4</sup>
<institution>Commonwealth Scientific and Industrial Research Organisation, Digital Productivity and Service</institution>
<country>Canberra, ACT, Australia</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Gitta Coaker, University of California, Davis, USA</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Murray Grant, University of Exeter, UK; Roger Wise, United States Department of Agriculture-Agricultural Research Service and Iowa State University, USA</p>
</fn>
<corresp id="fn001">*Correspondence: Thomas Kroj, Institut National de la Recherche Agronomique, Unité Mixtes de Recherche Biology and Genetics of Plant-Pathogen Interactions, TA A-54/K, Campus International de Baillarguet, 34398 Montpellier, France e-mail: <email xlink:type="simple">kroj@supagro.inra.fr</email>
;</corresp>
<corresp id="fn002">Peter N. Dodds, CSIRO Agriculture, Clunies Ross Street, GPO Box 1600, Canberra, ACT 2601, Australia e-mail: <email xlink:type="simple">peter.dodds@csiro.au</email>
</corresp>
<fn fn-type="other" id="fn003"><p>This article was submitted to Plant-Microbe Interaction, a section of the journal Frontiers in Plant Science.</p>
</fn>
</author-notes>
<pub-date pub-type="epreprint"><day>11</day>
<month>9</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>25</day>
<month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<volume>5</volume>
<elocation-id>606</elocation-id>
<history><date date-type="received"><day>15</day>
<month>8</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>17</day>
<month>10</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 Cesari, Bernoux, Moncuquet, Kroj and Dodds.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Plant immunity is often triggered by the specific recognition of pathogen effectors by intracellular nucleotide-binding, leucine-rich repeat receptors (NLR). Plant NLRs contain an N-terminal signaling domain that is mostly represented by either a Toll-interleukin1 receptor (TIR) domain or a coiled coil (CC) domain. In many cases, single NLR proteins are sufficient for both effector recognition and signaling activation. However, many paired NLRs have now been identified where both proteins are required to confer resistance to pathogens. Recent detailed studies on the <italic>Arabidopsis thaliana</italic>
TIR-NLR pair RRS1 and RPS4 and on the rice CC-NLR pair RGA4 and RGA5 have revealed for the first time how such protein pairs function together. In both cases, the paired partners interact physically to form a hetero-complex receptor in which each partner plays distinct roles in effector recognition or signaling activation, highlighting a conserved mode of action of NLR pairs across both monocotyledonous and dicotyledonous plants. We also describe an “integrated decoy” model for the function of these receptor complexes. In this model, a plant protein targeted by an effector has been duplicated and fused to one member of the NLR pair, where it acts as a bait to trigger defense signaling by the second NLR upon effector binding. This mechanism may be common to many other plant NLR pairs.</p>
</abstract>
<kwd-group><kwd>NLR protein pairs</kwd>
<kwd>integrated decoy</kwd>
<kwd>pathogen recognition</kwd>
<kwd>plant immunity</kwd>
<kwd><italic>Arabidopsis thaliana</italic>
</kwd>
<kwd>rice</kwd>
</kwd-group>
<counts><fig-count count="2"></fig-count>
<table-count count="2"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="67"></ref-count>
<page-count count="10"></page-count>
<word-count count="7611"></word-count>
</counts>
</article-meta>
</front>
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