ArachnoServer: a database of protein toxins from spiders
Identifieur interne : 002132 ( Pmc/Curation ); précédent : 002131; suivant : 002133ArachnoServer: a database of protein toxins from spiders
Auteurs : David La Wood [Australie] ; Tomas Miljenovi [Australie] ; Shuzhi Cai [Australie] ; Robert J. Raven [Australie] ; Quentin Kaas [Australie] ; Pierre Escoubas [France] ; Volker Herzig [Australie] ; David Wilson [Australie] ; Glenn F. King [Australie]Source :
- BMC Genomics [ 1471-2164 ] ; 2009.
Abstract
Venomous animals incapacitate their prey using complex venoms that can contain hundreds of unique protein toxins. The realisation that many of these toxins may have pharmaceutical and insecticidal potential due to their remarkable potency and selectivity against target receptors has led to an explosion in the number of new toxins being discovered and characterised. From an evolutionary perspective, spiders are the most successful venomous animals and they maintain by far the largest pool of toxic peptides. However, at present, there are no databases dedicated to spider toxins and hence it is difficult to realise their full potential as drugs, insecticides, and pharmacological probes.
We have developed ArachnoServer, a manually curated database that provides detailed information about proteinaceous toxins from spiders. Key features of ArachnoServer include a new molecular target ontology designed especially for venom toxins, the most up-to-date taxonomic information available, and a powerful advanced search interface. Toxin information can be browsed through dynamic trees, and each toxin has a dedicated page summarising all available information about its sequence, structure, and biological activity. ArachnoServer currently manages 567 protein sequences, 334 nucleic acid sequences, and 51 protein structures.
ArachnoServer provides a single source of high-quality information about proteinaceous spider toxins that will be an invaluable resource for pharmacologists, neuroscientists, toxinologists, medicinal chemists, ion channel scientists, clinicians, and structural biologists. ArachnoServer is available online at
Url:
DOI: 10.1186/1471-2164-10-375
PubMed: 19674480
PubMed Central: 2907703
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Venomous animals incapacitate their prey using complex venoms that can contain hundreds of unique protein toxins. The realisation that many of these toxins may have pharmaceutical and insecticidal potential due to their remarkable potency and selectivity against target receptors has led to an explosion in the number of new toxins being discovered and characterised. From an evolutionary perspective, spiders are the most successful venomous animals and they maintain by far the largest pool of toxic peptides. However, at present, there are no databases dedicated to spider toxins and hence it is difficult to realise their full potential as drugs, insecticides, and pharmacological probes.</p>
</sec>
<sec><title>Description</title>
<p>We have developed ArachnoServer, a manually curated database that provides detailed information about proteinaceous toxins from spiders. Key features of ArachnoServer include a new molecular target ontology designed especially for venom toxins, the most up-to-date taxonomic information available, and a powerful advanced search interface. Toxin information can be browsed through dynamic trees, and each toxin has a dedicated page summarising all available information about its sequence, structure, and biological activity. ArachnoServer currently manages 567 protein sequences, 334 nucleic acid sequences, and 51 protein structures.</p>
</sec>
<sec><title>Conclusion</title>
<p>ArachnoServer provides a single source of high-quality information about proteinaceous spider toxins that will be an invaluable resource for pharmacologists, neuroscientists, toxinologists, medicinal chemists, ion channel scientists, clinicians, and structural biologists. ArachnoServer is available online at <ext-link ext-link-type="uri" xlink:href="http://www.arachnoserver.org">http://www.arachnoserver.org</ext-link>
.</p>
</sec>
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</author>
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</author>
<author><name sortKey="Bourne, Pe" uniqKey="Bourne P">PE Bourne</name>
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</author>
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<author><name sortKey="Gogarten, Jp" uniqKey="Gogarten J">JP Gogarten</name>
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<author><name sortKey="King, Gf" uniqKey="King G">GF King</name>
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</author>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Genomics</journal-id>
<journal-title-group><journal-title>BMC Genomics</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2164</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19674480</article-id>
<article-id pub-id-type="pmc">2907703</article-id>
<article-id pub-id-type="publisher-id">1471-2164-10-375</article-id>
<article-id pub-id-type="doi">10.1186/1471-2164-10-375</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Database</subject>
</subj-group>
</article-categories>
<title-group><article-title>ArachnoServer: a database of protein toxins from spiders</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Wood</surname>
<given-names>David LA</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>d.wood@imb.uq.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Miljenović</surname>
<given-names>Tomas</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>t.miljenovic@imb.uq.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Cai</surname>
<given-names>Shuzhi</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>shuzhi.cai@qsa.qld.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Raven</surname>
<given-names>Robert J</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>robertr@qm.qld.gov.au</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Kaas</surname>
<given-names>Quentin</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>q.kaas@imb.uq.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Escoubas</surname>
<given-names>Pierre</given-names>
</name>
<xref ref-type="aff" rid="I5">5</xref>
<email>escoubas@ipmc.cnrs.fr</email>
</contrib>
<contrib contrib-type="author" id="A7"><name><surname>Herzig</surname>
<given-names>Volker</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>v.herzig@imb.uq.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A8"><name><surname>Wilson</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>david.wilson@imb.uq.edu.au</email>
</contrib>
<contrib contrib-type="author" corresp="yes" id="A9"><name><surname>King</surname>
<given-names>Glenn F</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>glenn.king@imb.uq.edu.au</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Queensland Facility for Advanced Bioinformatics, The University of Queensland, St Lucia, QLD 4072, Australia</aff>
<aff id="I2"><label>2</label>
ARC Centre of Excellence in Bioinformatics, The University of Queensland, St Lucia, QLD 4072, Australia</aff>
<aff id="I3"><label>3</label>
Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia</aff>
<aff id="I4"><label>4</label>
Queensland Museum, Brisbane QLD 4101, Australia</aff>
<aff id="I5"><label>5</label>
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 06560 Valbonne, France</aff>
<pub-date pub-type="collection"><year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>13</day>
<month>8</month>
<year>2009</year>
</pub-date>
<volume>10</volume>
<fpage>375</fpage>
<lpage>375</lpage>
<history><date date-type="received"><day>13</day>
<month>3</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>13</day>
<month>8</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>Copyright ©2009 Wood et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2009</copyright-year>
<copyright-holder>Wood et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.biomedcentral.com/1471-2164/10/375"></self-uri>
<abstract><sec><title>Background</title>
<p>Venomous animals incapacitate their prey using complex venoms that can contain hundreds of unique protein toxins. The realisation that many of these toxins may have pharmaceutical and insecticidal potential due to their remarkable potency and selectivity against target receptors has led to an explosion in the number of new toxins being discovered and characterised. From an evolutionary perspective, spiders are the most successful venomous animals and they maintain by far the largest pool of toxic peptides. However, at present, there are no databases dedicated to spider toxins and hence it is difficult to realise their full potential as drugs, insecticides, and pharmacological probes.</p>
</sec>
<sec><title>Description</title>
<p>We have developed ArachnoServer, a manually curated database that provides detailed information about proteinaceous toxins from spiders. Key features of ArachnoServer include a new molecular target ontology designed especially for venom toxins, the most up-to-date taxonomic information available, and a powerful advanced search interface. Toxin information can be browsed through dynamic trees, and each toxin has a dedicated page summarising all available information about its sequence, structure, and biological activity. ArachnoServer currently manages 567 protein sequences, 334 nucleic acid sequences, and 51 protein structures.</p>
</sec>
<sec><title>Conclusion</title>
<p>ArachnoServer provides a single source of high-quality information about proteinaceous spider toxins that will be an invaluable resource for pharmacologists, neuroscientists, toxinologists, medicinal chemists, ion channel scientists, clinicians, and structural biologists. ArachnoServer is available online at <ext-link ext-link-type="uri" xlink:href="http://www.arachnoserver.org">http://www.arachnoserver.org</ext-link>
.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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