REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH
Identifieur interne : 002038 ( Pmc/Curation ); précédent : 002037; suivant : 002039REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH
Auteurs : Vikas Gupta [Canada] ; Adriana K. Malone [États-Unis] ; Parameswaran N. Hari [États-Unis] ; Kwang Woo Ahn [États-Unis] ; Zhen-Huan Hu [États-Unis] ; Robert Peter Gale [Royaume-Uni] ; Karen K. Ballen [États-Unis] ; Mehdi Hamadani [États-Unis] ; Eduardo Olavarria [Espagne] ; Aaron T. Gerds [États-Unis] ; Edmund K. Waller [États-Unis] ; Luciano J. Costa [États-Unis] ; Joseph H. Antin [États-Unis] ; Rammurti T. Kamble [États-Unis] ; Koen M. Van Besien [États-Unis] ; Bipin N. Savani [États-Unis] ; Harry C. Schouten [Pays-Bas] ; Jeffrey Szer [Australie] ; Jean-Yves Cahn [France] ; Marcos J. De Lima [États-Unis] ; Baldeep Wirk [États-Unis] ; Mahmoud D. Aljurf [Arabie saoudite] ; Uday Popat [États-Unis] ; Nelli Bejanyan [États-Unis] ; Mark R. Litzow [États-Unis] ; Maxim Norkin [États-Unis] ; Ian D. Lewis [Australie] ; Gregory A. Hale [États-Unis] ; Ann E. Woolfrey [États-Unis] ; Alan M. Miller [États-Unis] ; Celalettin Ustun [États-Unis] ; Madan H. Jagasia [États-Unis] ; Michael Lill [États-Unis] ; Richard T. Maziarz [États-Unis] ; Jorge Cortes [États-Unis] ; Matt E. Kalaycio [États-Unis] ; Wael Saber [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2013.
Abstract
We evaluated the outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced intensity conditioning (RIC). Median age at HCT was 55 years. Donors were: matched sibling donor (MSD), 34%; HLA-well-matched unrelated donors (URD), 45%; and partially/mismatched URD, 21%. Risk stratification according to Dynamic International Prognostic Scoring System (DIPSS): low, 12%; intermediate-1, 49%; intermediate-2, 37%; and high, 1%. The probability of survival at 5-years was 47% (95% CI 40–53). In a multivariate analysis, donor type was the only independent factor associated with survival. Adjusted probabilities of survival at 5-years for MSD, well matched URD and partially matched/mismatched URD were 56% (95% CI 44–67), 48% (95% CI 37–58), and 34% (95% CI 21–47), respectively (p=0.002). Relative risks (RR) for NRM for well-matched URD and partially matched/mismatched URD were 3.92 (p=0.006) and 9.37 (p<0.0001), respectively. A trend towards increased NRM (RR 1.7, p=0.07) and inferior survival (RR 1.37, p=0.10) was observed in DIPSS-intermediate-2/high-risk patients compared to DIPSS-low/intermediate-1 risk patients.
RIC HCT is a potentially curative option for patients with MF, and donor type is the most important factor influencing survival in these patients.
Url:
DOI: 10.1016/j.bbmt.2013.10.018
PubMed: 24161923
PubMed Central: 3886623
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002187
Links to Exploration step
PMC:3886623Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH</title>
<author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Princess Margaret Cancer Center, University of Toronto, Toronto, CANADA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Center, University of Toronto, Toronto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Malone, Adriana K" sort="Malone, Adriana K" uniqKey="Malone A" first="Adriana K." last="Malone">Adriana K. Malone</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Mount Sinai Medical Center, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Mount Sinai Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hari, Parameswaran N" sort="Hari, Parameswaran N" uniqKey="Hari P" first="Parameswaran N." last="Hari">Parameswaran N. Hari</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Massachusetts General Hospital, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<affiliation wicri:level="2"><nlm:aff id="A6">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>West Virginia University Hospitals, Inc., Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona, SPAIN</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Espagne</country>
<wicri:regionArea>Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerds, Aaron T" sort="Gerds, Aaron T" uniqKey="Gerds A" first="Aaron T." last="Gerds">Aaron T. Gerds</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston, SC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Sud</region>
</placeName>
<wicri:cityArea>Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Dana Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Cell and Gene Therapy, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Besien, Koen M" sort="Van Besien, Koen M" uniqKey="Van Besien K" first="Koen M." last="Van Besien">Koen M. Van Besien</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Stem Cell Transplant, Weill Cornell Medical College, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Stem Cell Transplant, Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Academische Ziekenhuis Maastricht, Maastricht, NETHERLANDS</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria, AUSTRALIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Department of Hematology, University Hospital, Grenoble, FRANCE</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A20">King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country>
<wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bejanyan, Nelli" sort="Bejanyan, Nelli" uniqKey="Bejanyan N" first="Nelli" last="Bejanyan">Nelli Bejanyan</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Mayo Clinic Rochester, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name>
<affiliation wicri:level="2"><nlm:aff id="A25">All Children's Hospital, St. Petersburg, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>All Children's Hospital, St. Petersburg</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Baylor University Medical Center, Dallas, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Baylor University Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
<wicri:cityArea>Center for Hematologic Malignancies, Oregon Health and Science University, Portland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24161923</idno>
<idno type="pmc">3886623</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886623</idno>
<idno type="RBID">PMC:3886623</idno>
<idno type="doi">10.1016/j.bbmt.2013.10.018</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002187</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002187</idno>
<idno type="wicri:Area/Pmc/Curation">002038</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002038</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH</title>
<author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Princess Margaret Cancer Center, University of Toronto, Toronto, CANADA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Center, University of Toronto, Toronto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Malone, Adriana K" sort="Malone, Adriana K" uniqKey="Malone A" first="Adriana K." last="Malone">Adriana K. Malone</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Mount Sinai Medical Center, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Mount Sinai Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hari, Parameswaran N" sort="Hari, Parameswaran N" uniqKey="Hari P" first="Parameswaran N." last="Hari">Parameswaran N. Hari</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Massachusetts General Hospital, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<affiliation wicri:level="2"><nlm:aff id="A6">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>West Virginia University Hospitals, Inc., Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona, SPAIN</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Espagne</country>
<wicri:regionArea>Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerds, Aaron T" sort="Gerds, Aaron T" uniqKey="Gerds A" first="Aaron T." last="Gerds">Aaron T. Gerds</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston, SC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Sud</region>
</placeName>
<wicri:cityArea>Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Dana Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Cell and Gene Therapy, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Besien, Koen M" sort="Van Besien, Koen M" uniqKey="Van Besien K" first="Koen M." last="Van Besien">Koen M. Van Besien</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Stem Cell Transplant, Weill Cornell Medical College, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Stem Cell Transplant, Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Academische Ziekenhuis Maastricht, Maastricht, NETHERLANDS</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria, AUSTRALIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Department of Hematology, University Hospital, Grenoble, FRANCE</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A20">King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country>
<wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bejanyan, Nelli" sort="Bejanyan, Nelli" uniqKey="Bejanyan N" first="Nelli" last="Bejanyan">Nelli Bejanyan</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Mayo Clinic Rochester, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name>
<affiliation wicri:level="2"><nlm:aff id="A25">All Children's Hospital, St. Petersburg, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>All Children's Hospital, St. Petersburg</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Baylor University Medical Center, Dallas, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Baylor University Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
<wicri:cityArea>Center for Hematologic Malignancies, Oregon Health and Science University, Portland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">We evaluated the outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced intensity conditioning (RIC). Median age at HCT was 55 years. Donors were: matched sibling donor (MSD), 34%; HLA-well-matched unrelated donors (URD), 45%; and partially/mismatched URD, 21%. Risk stratification according to Dynamic International Prognostic Scoring System (DIPSS): low, 12%; intermediate-1, 49%; intermediate-2, 37%; and high, 1%. The probability of survival at 5-years was 47% (95% CI 40–53). In a multivariate analysis, donor type was the only independent factor associated with survival. Adjusted probabilities of survival at 5-years for MSD, well matched URD and partially matched/mismatched URD were 56% (95% CI 44–67), 48% (95% CI 37–58), and 34% (95% CI 21–47), respectively (p=0.002). Relative risks (RR) for NRM for well-matched URD and partially matched/mismatched URD were 3.92 (p=0.006) and 9.37 (p<0.0001), respectively. A trend towards increased NRM (RR 1.7, p=0.07) and inferior survival (RR 1.37, p=0.10) was observed in DIPSS-intermediate-2/high-risk patients compared to DIPSS-low/intermediate-1 risk patients.</p>
<p id="P2">RIC HCT is a potentially curative option for patients with MF, and donor type is the most important factor influencing survival in these patients.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20830</journal-id>
<journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id>
<journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id>
<journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title>
</journal-title-group>
<issn pub-type="ppub">1083-8791</issn>
<issn pub-type="epub">1523-6536</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24161923</article-id>
<article-id pub-id-type="pmc">3886623</article-id>
<article-id pub-id-type="doi">10.1016/j.bbmt.2013.10.018</article-id>
<article-id pub-id-type="manuscript">NIHMS544568</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Gupta</surname>
<given-names>Vikas</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Malone</surname>
<given-names>Adriana K.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hari</surname>
<given-names>Parameswaran N.</given-names>
</name>
<degrees>MD, MS</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ahn</surname>
<given-names>Kwang Woo</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hu</surname>
<given-names>Zhen-Huan</given-names>
</name>
<degrees>MS</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gale</surname>
<given-names>Robert Peter</given-names>
</name>
<degrees>MD, PhD, DSc(hon); FACP</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ballen</surname>
<given-names>Karen K.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamadani</surname>
<given-names>Mehdi</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olavarria</surname>
<given-names>Eduardo</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gerds</surname>
<given-names>Aaron T.</given-names>
</name>
<degrees>MD, MS</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Waller</surname>
<given-names>Edmund K.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Costa</surname>
<given-names>Luciano J.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Antin</surname>
<given-names>Joseph H.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kamble</surname>
<given-names>Rammurti T.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Besien</surname>
<given-names>Koen M.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Savani</surname>
<given-names>Bipin N.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schouten</surname>
<given-names>Harry C.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szer</surname>
<given-names>Jeffrey</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cahn</surname>
<given-names>Jean-Yves</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Lima</surname>
<given-names>Marcos J.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wirk</surname>
<given-names>Baldeep</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aljurf</surname>
<given-names>Mahmoud D.</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Popat</surname>
<given-names>Uday</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bejanyan</surname>
<given-names>Nelli</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Litzow</surname>
<given-names>Mark R.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Norkin</surname>
<given-names>Maxim</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lewis</surname>
<given-names>Ian D.</given-names>
</name>
<degrees>MBBS, PhD</degrees>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hale</surname>
<given-names>Gregory A.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Woolfrey</surname>
<given-names>Ann E.</given-names>
</name>
<degrees>MD, BA</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miller</surname>
<given-names>Alan M.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ustun</surname>
<given-names>Celalettin</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jagasia</surname>
<given-names>Madan H.</given-names>
</name>
<degrees>MBBS, MS</degrees>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lill</surname>
<given-names>Michael</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maziarz</surname>
<given-names>Richard T.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cortes</surname>
<given-names>Jorge</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kalaycio</surname>
<given-names>Matt E.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saber</surname>
<given-names>Wael</given-names>
</name>
<degrees>MD, MS</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Princess Margaret Cancer Center, University of Toronto, Toronto, CANADA</aff>
<aff id="A2"><label>2</label>
Mount Sinai Medical Center, New York, NY</aff>
<aff id="A3"><label>3</label>
Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</aff>
<aff id="A4"><label>4</label>
Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</aff>
<aff id="A5"><label>5</label>
Massachusetts General Hospital, Boston, MA</aff>
<aff id="A6"><label>6</label>
West Virginia University Hospitals, Inc., Morgantown, WV</aff>
<aff id="A7"><label>7</label>
Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona, SPAIN</aff>
<aff id="A8"><label>8</label>
Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</aff>
<aff id="A9"><label>9</label>
Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</aff>
<aff id="A10"><label>10</label>
Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston, SC</aff>
<aff id="A11"><label>11</label>
Dana Farber Cancer Institute, Boston, MA</aff>
<aff id="A12"><label>12</label>
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</aff>
<aff id="A13"><label>13</label>
Stem Cell Transplant, Weill Cornell Medical College, New York, NY</aff>
<aff id="A14"><label>14</label>
Vanderbilt University Medical Center, Nashville, TN</aff>
<aff id="A15"><label>15</label>
Academische Ziekenhuis Maastricht, Maastricht, NETHERLANDS</aff>
<aff id="A16"><label>16</label>
Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria, AUSTRALIA</aff>
<aff id="A17"><label>17</label>
Department of Hematology, University Hospital, Grenoble, FRANCE</aff>
<aff id="A18"><label>18</label>
Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</aff>
<aff id="A19"><label>19</label>
Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</aff>
<aff id="A20"><label>20</label>
King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</aff>
<aff id="A21"><label>21</label>
Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</aff>
<aff id="A22"><label>22</label>
Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</aff>
<aff id="A23"><label>23</label>
Mayo Clinic Rochester, Rochester, MN</aff>
<aff id="A24"><label>24</label>
Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</aff>
<aff id="A25"><label>25</label>
All Children's Hospital, St. Petersburg, FL</aff>
<aff id="A26"><label>26</label>
Baylor University Medical Center, Dallas, TX</aff>
<aff id="A27"><label>27</label>
Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA</aff>
<aff id="A28"><label>28</label>
Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</aff>
<author-notes><corresp id="CR1"><bold>Corresponding author:</bold>
Vikas Gupta, MD; Princess Margaret Cancer Center, 610 University Avenue, Suite 5-217, Toronto, ON M5G2M9, Canada; Phone: 416-946-4521; Fax: 416-946-6546; <email>vikas.gupta@uhn.on.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>2</day>
<month>1</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>10</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>1</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>1</month>
<year>2015</year>
</pub-date>
<volume>20</volume>
<issue>1</issue>
<elocation-id>10.1016/j.bbmt.2013.10.018</elocation-id>
<permissions><copyright-statement>© 2013 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p id="P1">We evaluated the outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced intensity conditioning (RIC). Median age at HCT was 55 years. Donors were: matched sibling donor (MSD), 34%; HLA-well-matched unrelated donors (URD), 45%; and partially/mismatched URD, 21%. Risk stratification according to Dynamic International Prognostic Scoring System (DIPSS): low, 12%; intermediate-1, 49%; intermediate-2, 37%; and high, 1%. The probability of survival at 5-years was 47% (95% CI 40–53). In a multivariate analysis, donor type was the only independent factor associated with survival. Adjusted probabilities of survival at 5-years for MSD, well matched URD and partially matched/mismatched URD were 56% (95% CI 44–67), 48% (95% CI 37–58), and 34% (95% CI 21–47), respectively (p=0.002). Relative risks (RR) for NRM for well-matched URD and partially matched/mismatched URD were 3.92 (p=0.006) and 9.37 (p<0.0001), respectively. A trend towards increased NRM (RR 1.7, p=0.07) and inferior survival (RR 1.37, p=0.10) was observed in DIPSS-intermediate-2/high-risk patients compared to DIPSS-low/intermediate-1 risk patients.</p>
<p id="P2">RIC HCT is a potentially curative option for patients with MF, and donor type is the most important factor influencing survival in these patients.</p>
</abstract>
<kwd-group><kwd>Myelofibrosis</kwd>
<kwd>allogeneic transplantation</kwd>
<kwd>reduced intensity</kwd>
<kwd>prognosis</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source>
<award-id>U10 HL069294 || HL</award-id>
</award-group>
<award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source>
<award-id>T32 HL007093 || HL</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002038 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 002038 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:3886623 |texte= REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:24161923" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |