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Risk Factors for Borderline Personality Disorder in Treatment Seeking Patients with a Substance Use Disorder: An International Multicenter Study

Identifieur interne : 002031 ( Pmc/Curation ); précédent : 002030; suivant : 002032

Risk Factors for Borderline Personality Disorder in Treatment Seeking Patients with a Substance Use Disorder: An International Multicenter Study

Auteurs : Manuela Wapp [Suisse] ; Geurt Van De Glind [Pays-Bas] ; Katelijne Van Emmerik-Van Oortmerssen [Pays-Bas] ; Geert Dom [Belgique] ; Sofie Verspreet [Belgique] ; Pieter Jan Carpentier [Pays-Bas] ; Josep Antoni Ramos-Quiroga [Espagne] ; Arvid Skutle [Norvège] ; Eli-Torlid Bu [Norvège] ; Johan Franck [Suède] ; Maija Konstenius [Suède] ; Sharlene Kaye [Australie] ; Zsolt Demetrovics [Hongrie] ; Csaba Barta [Hongrie] ; Melina Fatséas [France] ; Marc Auriacombe [France] ; Brian Johnson [États-Unis] ; Stephen V. Faraone [États-Unis] ; Frances R. Levin [États-Unis] ; Steve Allsop [Australie] ; Susan Carruthers [Australie] ; Robert A. Schoevers [Pays-Bas] ; Maarten W. J. Koeter [Pays-Bas] ; Wim Van Den Brink [Pays-Bas] ; Franz Moggi [Suisse]

Source :

RBID : PMC:4869722

Abstract

Borderline personality disorder (BPD) and substance use disorders (SUDs) often co-occur, partly because they share risk factors. In this international multicenter study, risk factors for BPD were examined for SUD patients. In total, 1,205 patients were comprehensively examined by standardized interviews and questionnaires on psychiatric diagnosis and risk factors, and it was found that 1,033 (85.7%) had SUDs without BPD (SUD) and 172 (14.3%) had SUD with BPD (SUD + BPD). SUD + BPD patients were significantly younger, more often females and more often diagnosed with comorbid adult attention deficit/hyperactivity disorder. SUD + BPD patients did not differ from SUD patients on most risk factors typical for SUD such as maternal use of drugs during pregnancy or parents having any SUD. However, SUD + BPD patients did have a higher risk of having experienced emotional and physical abuse, neglect, or family violence in childhood compared to SUD patients, suggesting that child abuse and family violence are BPD-specific risk factors in patients with SUDs.


Url:
DOI: 10.1159/000371724
PubMed: 25832736
PubMed Central: 4869722

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PMC:4869722

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<name sortKey="Ramos Quiroga, Josep Antoni" sort="Ramos Quiroga, Josep Antoni" uniqKey="Ramos Quiroga J" first="Josep Antoni" last="Ramos-Quiroga">Josep Antoni Ramos-Quiroga</name>
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<name sortKey="Franck, Johan" sort="Franck, Johan" uniqKey="Franck J" first="Johan" last="Franck">Johan Franck</name>
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<name sortKey="Konstenius, Maija" sort="Konstenius, Maija" uniqKey="Konstenius M" first="Maija" last="Konstenius">Maija Konstenius</name>
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<name sortKey="Kaye, Sharlene" sort="Kaye, Sharlene" uniqKey="Kaye S" first="Sharlene" last="Kaye">Sharlene Kaye</name>
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<name sortKey="Demetrovics, Zsolt" sort="Demetrovics, Zsolt" uniqKey="Demetrovics Z" first="Zsolt" last="Demetrovics">Zsolt Demetrovics</name>
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<name sortKey="Fatseas, Melina" sort="Fatseas, Melina" uniqKey="Fatseas M" first="Melina" last="Fatséas">Melina Fatséas</name>
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<name sortKey="Auriacombe, Marc" sort="Auriacombe, Marc" uniqKey="Auriacombe M" first="Marc" last="Auriacombe">Marc Auriacombe</name>
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<name sortKey="Johnson, Brian" sort="Johnson, Brian" uniqKey="Johnson B" first="Brian" last="Johnson">Brian Johnson</name>
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<name sortKey="Faraone, Stephen V" sort="Faraone, Stephen V" uniqKey="Faraone S" first="Stephen V." last="Faraone">Stephen V. Faraone</name>
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<name sortKey="Levin, Frances R" sort="Levin, Frances R" uniqKey="Levin F" first="Frances R." last="Levin">Frances R. Levin</name>
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<name sortKey="Allsop, Steve" sort="Allsop, Steve" uniqKey="Allsop S" first="Steve" last="Allsop">Steve Allsop</name>
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<name sortKey="Carruthers, Susan" sort="Carruthers, Susan" uniqKey="Carruthers S" first="Susan" last="Carruthers">Susan Carruthers</name>
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<name sortKey="Schoevers, Robert A" sort="Schoevers, Robert A" uniqKey="Schoevers R" first="Robert A." last="Schoevers">Robert A. Schoevers</name>
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<nlm:aff id="A19">Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
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<name sortKey="Koeter, Maarten W J" sort="Koeter, Maarten W J" uniqKey="Koeter M" first="Maarten W. J." last="Koeter">Maarten W. J. Koeter</name>
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<nlm:aff id="A4">Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam</nlm:aff>
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<name sortKey="Van Den Brink, Wim" sort="Van Den Brink, Wim" uniqKey="Van Den Brink W" first="Wim" last="Van Den Brink">Wim Van Den Brink</name>
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<nlm:aff id="A4">Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam</nlm:aff>
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<name sortKey="Moggi, Franz" sort="Moggi, Franz" uniqKey="Moggi F" first="Franz" last="Moggi">Franz Moggi</name>
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<nlm:aff id="A1">University Hospital of Psychiatry, University of Bern, Bern, Switzerland</nlm:aff>
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<nlm:aff id="A20">Department of Psychology, University of Fribourg, Fribourg, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
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<title xml:lang="en" level="a" type="main">Risk Factors for Borderline Personality Disorder in Treatment Seeking Patients with a Substance Use Disorder: An International Multicenter Study</title>
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<name sortKey="Dom, Geert" sort="Dom, Geert" uniqKey="Dom G" first="Geert" last="Dom">Geert Dom</name>
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<name sortKey="Verspreet, Sofie" sort="Verspreet, Sofie" uniqKey="Verspreet S" first="Sofie" last="Verspreet">Sofie Verspreet</name>
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<name sortKey="Carpentier, Pieter Jan" sort="Carpentier, Pieter Jan" uniqKey="Carpentier P" first="Pieter Jan" last="Carpentier">Pieter Jan Carpentier</name>
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<nlm:aff id="A7">Reinier van Arkel Groep, ‘s-Hertogenbosch, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
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<name sortKey="Ramos Quiroga, Josep Antoni" sort="Ramos Quiroga, Josep Antoni" uniqKey="Ramos Quiroga J" first="Josep Antoni" last="Ramos-Quiroga">Josep Antoni Ramos-Quiroga</name>
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<nlm:aff id="A8">Servei de Psiquiatria, Hospital Universitari Vall d’Hebron, CIBERSAM, Department of Psychiatry, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
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<name sortKey="Skutle, Arvid" sort="Skutle, Arvid" uniqKey="Skutle A" first="Arvid" last="Skutle">Arvid Skutle</name>
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<nlm:aff id="A9">Bergen Clinics Foundation, Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Bergen Clinics Foundation, Bergen</wicri:regionArea>
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<name sortKey="Bu, Eli Torlid" sort="Bu, Eli Torlid" uniqKey="Bu E" first="Eli-Torlid" last="Bu">Eli-Torlid Bu</name>
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<nlm:aff id="A9">Bergen Clinics Foundation, Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Bergen Clinics Foundation, Bergen</wicri:regionArea>
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<name sortKey="Franck, Johan" sort="Franck, Johan" uniqKey="Franck J" first="Johan" last="Franck">Johan Franck</name>
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<region type="state">État de New York</region>
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<region type="state">État de New York</region>
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<name sortKey="Levin, Frances R" sort="Levin, Frances R" uniqKey="Levin F" first="Frances R." last="Levin">Frances R. Levin</name>
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<name sortKey="Allsop, Steve" sort="Allsop, Steve" uniqKey="Allsop S" first="Steve" last="Allsop">Steve Allsop</name>
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<nlm:aff id="A18">National Drug Research Institute, Curtin University of Technology, Perth, W.A., Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>National Drug Research Institute, Curtin University of Technology, Perth, W.A.</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Carruthers, Susan" sort="Carruthers, Susan" uniqKey="Carruthers S" first="Susan" last="Carruthers">Susan Carruthers</name>
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<nlm:aff id="A18">National Drug Research Institute, Curtin University of Technology, Perth, W.A., Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>National Drug Research Institute, Curtin University of Technology, Perth, W.A.</wicri:regionArea>
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<author>
<name sortKey="Schoevers, Robert A" sort="Schoevers, Robert A" uniqKey="Schoevers R" first="Robert A." last="Schoevers">Robert A. Schoevers</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Koeter, Maarten W J" sort="Koeter, Maarten W J" uniqKey="Koeter M" first="Maarten W. J." last="Koeter">Maarten W. J. Koeter</name>
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<nlm:aff id="A4">Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam</nlm:aff>
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<placeName>
<settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
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<author>
<name sortKey="Van Den Brink, Wim" sort="Van Den Brink, Wim" uniqKey="Van Den Brink W" first="Wim" last="Van Den Brink">Wim Van Den Brink</name>
<affiliation wicri:level="4">
<nlm:aff id="A4">Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam</nlm:aff>
<country>Pays-Bas</country>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
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</author>
<author>
<name sortKey="Moggi, Franz" sort="Moggi, Franz" uniqKey="Moggi F" first="Franz" last="Moggi">Franz Moggi</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">University Hospital of Psychiatry, University of Bern, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>University Hospital of Psychiatry, University of Bern, Bern</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A20">Department of Psychology, University of Fribourg, Fribourg, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Psychology, University of Fribourg, Fribourg</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">European addiction research</title>
<idno type="ISSN">1022-6877</idno>
<idno type="eISSN">1421-9891</idno>
<imprint>
<date when="2015">2015</date>
</imprint>
</series>
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<front>
<div type="abstract" xml:lang="en">
<p id="P2">Borderline personality disorder (BPD) and substance use disorders (SUDs) often co-occur, partly because they share risk factors. In this international multicenter study, risk factors for BPD were examined for SUD patients. In total, 1,205 patients were comprehensively examined by standardized interviews and questionnaires on psychiatric diagnosis and risk factors, and it was found that 1,033 (85.7%) had SUDs without BPD (SUD) and 172 (14.3%) had SUD with BPD (SUD + BPD). SUD + BPD patients were significantly younger, more often females and more often diagnosed with comorbid adult attention deficit/hyperactivity disorder. SUD + BPD patients did not differ from SUD patients on most risk factors typical for SUD such as maternal use of drugs during pregnancy or parents having any SUD. However, SUD + BPD patients did have a higher risk of having experienced emotional and physical abuse, neglect, or family violence in childhood compared to SUD patients, suggesting that child abuse and family violence are BPD-specific risk factors in patients with SUDs.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">9502920</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21104</journal-id>
<journal-id journal-id-type="nlm-ta">Eur Addict Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Eur Addict Res</journal-id>
<journal-title-group>
<journal-title>European addiction research</journal-title>
</journal-title-group>
<issn pub-type="ppub">1022-6877</issn>
<issn pub-type="epub">1421-9891</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">25832736</article-id>
<article-id pub-id-type="pmc">4869722</article-id>
<article-id pub-id-type="doi">10.1159/000371724</article-id>
<article-id pub-id-type="manuscript">NIHMS785796</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Risk Factors for Borderline Personality Disorder in Treatment Seeking Patients with a Substance Use Disorder: An International Multicenter Study</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Wapp</surname>
<given-names>Manuela</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van de Glind</surname>
<given-names>Geurt</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van Emmerik-van Oortmerssen</surname>
<given-names>Katelijne</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dom</surname>
<given-names>Geert</given-names>
</name>
<xref ref-type="aff" rid="A6">f</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Verspreet</surname>
<given-names>Sofie</given-names>
</name>
<xref ref-type="aff" rid="A6">f</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Carpentier</surname>
<given-names>Pieter Jan</given-names>
</name>
<xref ref-type="aff" rid="A7">g</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ramos-Quiroga</surname>
<given-names>Josep Antoni</given-names>
</name>
<xref ref-type="aff" rid="A8">h</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Skutle</surname>
<given-names>Arvid</given-names>
</name>
<xref ref-type="aff" rid="A9">i</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bu</surname>
<given-names>Eli-Torlid</given-names>
</name>
<xref ref-type="aff" rid="A9">i</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Franck</surname>
<given-names>Johan</given-names>
</name>
<xref ref-type="aff" rid="A10">j</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Konstenius</surname>
<given-names>Maija</given-names>
</name>
<xref ref-type="aff" rid="A10">j</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kaye</surname>
<given-names>Sharlene</given-names>
</name>
<xref ref-type="aff" rid="A11">k</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Demetrovics</surname>
<given-names>Zsolt</given-names>
</name>
<xref ref-type="aff" rid="A12">l</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Barta</surname>
<given-names>Csaba</given-names>
</name>
<xref ref-type="aff" rid="A13">m</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fatséas</surname>
<given-names>Melina</given-names>
</name>
<xref ref-type="aff" rid="A14">n</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Auriacombe</surname>
<given-names>Marc</given-names>
</name>
<xref ref-type="aff" rid="A14">n</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Johnson</surname>
<given-names>Brian</given-names>
</name>
<xref ref-type="aff" rid="A15">o</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Faraone</surname>
<given-names>Stephen V.</given-names>
</name>
<xref ref-type="aff" rid="A15">o</xref>
<xref ref-type="aff" rid="A16">p</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Levin</surname>
<given-names>Frances R.</given-names>
</name>
<xref ref-type="aff" rid="A17">q</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Allsop</surname>
<given-names>Steve</given-names>
</name>
<xref ref-type="aff" rid="A18">r</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Carruthers</surname>
<given-names>Susan</given-names>
</name>
<xref ref-type="aff" rid="A18">r</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schoevers</surname>
<given-names>Robert A.</given-names>
</name>
<xref ref-type="aff" rid="A19">s</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Koeter</surname>
<given-names>Maarten W.J.</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van den Brink</surname>
<given-names>Wim</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Moggi</surname>
<given-names>Franz</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A20">t</xref>
</contrib>
<contrib contrib-type="author">
<collab>IASP Research Group</collab>
</contrib>
</contrib-group>
<aff id="A1">
<label>a</label>
University Hospital of Psychiatry, University of Bern, Bern, Switzerland</aff>
<aff id="A2">
<label>b</label>
Center for Cognition, Learning and Memory, University of Bern, Bern, Switzerland</aff>
<aff id="A3">
<label>c</label>
Trimbos Institute and ICASA Foundation, Utrecht</aff>
<aff id="A4">
<label>d</label>
Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam</aff>
<aff id="A5">
<label>e</label>
The Netherlands Arkin, Amsterdam, The Netherlands</aff>
<aff id="A6">
<label>f</label>
Collaborative Antwerp Psychiatry Research Institute (CAPRI, UA), PC Alexian Brothers, Boechout, Belgium</aff>
<aff id="A7">
<label>g</label>
Reinier van Arkel Groep, ‘s-Hertogenbosch, The Netherlands</aff>
<aff id="A8">
<label>h</label>
Servei de Psiquiatria, Hospital Universitari Vall d’Hebron, CIBERSAM, Department of Psychiatry, Universitat Autònoma de Barcelona, Barcelona, Spain</aff>
<aff id="A9">
<label>i</label>
Bergen Clinics Foundation, Bergen, Norway</aff>
<aff id="A10">
<label>j</label>
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institute, Stockholm, Sweden</aff>
<aff id="A11">
<label>k</label>
National Drug and Alcohol Research Centre, UNSW Australia, Sydney, N.S.W., Australia</aff>
<aff id="A12">
<label>l</label>
Institute of Psychology, Eötvös Loránd University, Budapest, Hungary</aff>
<aff id="A13">
<label>m</label>
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary</aff>
<aff id="A14">
<label>n</label>
Laboratoire de Psychiatrie, Département d’Addictologie, Université de Bordeaux, Bordeaux, France</aff>
<aff id="A15">
<label>o</label>
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, N.Y.</aff>
<aff id="A16">
<label>p</label>
Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, N.Y.</aff>
<aff id="A17">
<label>q</label>
Columbia University, The New York State Psychiatric Institute, New York, N.Y., USA</aff>
<aff id="A18">
<label>r</label>
National Drug Research Institute, Curtin University of Technology, Perth, W.A., Australia</aff>
<aff id="A19">
<label>s</label>
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff>
<aff id="A20">
<label>t</label>
Department of Psychology, University of Fribourg, Fribourg, Switzerland</aff>
<author-notes>
<corresp id="CR1">Prof. Franz Moggi, PhD, EMBA, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, CH–3000 Bern 60 (Switzerland),
<email>moggi@puk.unibe.ch</email>
</corresp>
<fn id="FN1">
<p id="P1">The IASP Research Group also includes: Eva Karin Løvaas, Kari Lossius, Anneke van Wamel, Geert Bosma, David Hay, Sara Wallhed, Marion Malivert, Romain Debrabant, Therese Dahl, Miguel Casas, Carlos Roncero, Constanza Daigre, Rutger-Jan van der Gaag, Atul Beniwal, Máté Kapitány-Fövény, Louisa Degenhardt, Joanne Cassar, Jesse Young and Merete Möller.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>12</day>
<month>5</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>01</day>
<month>4</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub">
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>17</day>
<month>5</month>
<year>2016</year>
</pub-date>
<volume>21</volume>
<issue>4</issue>
<fpage>188</fpage>
<lpage>194</lpage>
<pmc-comment>elocation-id from pubmed: 10.1159/000371724</pmc-comment>
<abstract>
<p id="P2">Borderline personality disorder (BPD) and substance use disorders (SUDs) often co-occur, partly because they share risk factors. In this international multicenter study, risk factors for BPD were examined for SUD patients. In total, 1,205 patients were comprehensively examined by standardized interviews and questionnaires on psychiatric diagnosis and risk factors, and it was found that 1,033 (85.7%) had SUDs without BPD (SUD) and 172 (14.3%) had SUD with BPD (SUD + BPD). SUD + BPD patients were significantly younger, more often females and more often diagnosed with comorbid adult attention deficit/hyperactivity disorder. SUD + BPD patients did not differ from SUD patients on most risk factors typical for SUD such as maternal use of drugs during pregnancy or parents having any SUD. However, SUD + BPD patients did have a higher risk of having experienced emotional and physical abuse, neglect, or family violence in childhood compared to SUD patients, suggesting that child abuse and family violence are BPD-specific risk factors in patients with SUDs.</p>
</abstract>
<kwd-group>
<kwd>Risk factors</kwd>
<kwd>Substance use disorder</kwd>
<kwd>Borderline personality disorder</kwd>
<kwd>Comorbidity</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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