Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
Identifieur interne : 002004 ( Pmc/Curation ); précédent : 002003; suivant : 002005Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
Auteurs : Alison M. Dunning [Royaume-Uni] ; Kyriaki Michailidou [Royaume-Uni] ; Karoline B. Kuchenbaecker [Royaume-Uni] ; Deborah Thompson [Royaume-Uni] ; Juliet D. French [Australie] ; Jonathan Beesley [Australie] ; Catherine S. Healey [Royaume-Uni] ; Siddhartha Kar [Royaume-Uni] ; Karen A. Pooley [Royaume-Uni] ; Elena Lopez-Knowles [Royaume-Uni] ; Ed Dicks [Royaume-Uni] ; Daniel Barrowdale [Royaume-Uni] ; Nicholas A. Sinnott-Armstrong [États-Unis] ; Richard C. Sallari [États-Unis] ; Kristine M. Hillman [Australie] ; Susanne Kaufmann [Australie] ; Haran Sivakumaran [Australie] ; Mahdi Moradi Marjaneh [Australie] ; Jason S. Lee [Australie] ; Margaret Hills [Royaume-Uni] ; Monika Jarosz [Royaume-Uni] ; Suzie Drury [Royaume-Uni] ; Sander Canisius [Pays-Bas] ; Manjeet K. Bolla [Royaume-Uni] ; Joe Dennis [Royaume-Uni] ; Qin Wang [Royaume-Uni] ; John L. Hopper [Australie] ; Melissa C. Southey [Australie] ; Annegien Broeks [Pays-Bas] ; Marjanka K. Schmidt [Pays-Bas] ; Artitaya Lophatananon [Royaume-Uni] ; Kenneth Muir [Royaume-Uni] ; Matthias W. Beckmann [Allemagne] ; Peter A. Fasching [Allemagne, États-Unis] ; Isabel Dos-Santos-Silva [Royaume-Uni] ; Julian Peto [Royaume-Uni] ; Elinor J. Sawyer [Royaume-Uni] ; Ian Tomlinson [Royaume-Uni] ; Barbara Burwinkel [Allemagne] ; Frederik Marme [Allemagne] ; Pascal Guénel [France] ; Thérèse Truong [France] ; Stig E. Bojesen [Danemark] ; Henrik Flyger [Danemark] ; Anna González-Neira [Espagne] ; Jose I A. Perez [Espagne] ; Hoda Anton-Culver [États-Unis] ; Lee Eunjung [États-Unis] ; Volker Arndt [Allemagne] ; Hermann Brenner [Allemagne] ; Alfons Meindl [Allemagne] ; Rita K. Schmutzler [Allemagne] ; Hiltrud Brauch [Allemagne] ; Ute Hamann [Allemagne] ; Kristiina Aittom Ki [Finlande] ; Carl Blomqvist [Finlande] ; Hidemi Ito [Japon] ; Keitaro Matsuo [Japon] ; Natasha Bogdanova [Allemagne] ; Thilo Dörk [Allemagne] ; Annika Lindblom [Suède] ; Sara Margolin [Suède] ; Veli-Matti Kosma [Finlande] ; Arto Mannermaa [Finlande] ; Chiu-Chen Tseng [États-Unis] ; Anna H. Wu [États-Unis] ; Diether Lambrechts [Belgique] ; Hans Wildiers [Belgique] ; Jenny Chang-Claude [Allemagne] ; Anja Rudolph [Allemagne] ; Paolo Peterlongo [Italie] ; Paolo Radice [Italie] ; Janet E. Olson [États-Unis] ; Graham G. Giles [Australie] ; Roger L. Milne [Australie] ; Christopher A. Haiman [États-Unis] ; Brian E. Henderson [États-Unis] ; Mark S. Goldberg [Canada] ; Soo H. Teo [Malaisie] ; Cheng Har Yip [Malaisie] ; Silje Nord [Norvège] ; Anne-Lise Borresen-Dale [Norvège] ; Vessela Kristensen [Norvège] ; Jirong Long [États-Unis] ; Wei Zheng [États-Unis] ; Katri Pylk S [Finlande] ; Robert Winqvist [Finlande] ; Irene L. Andrulis [Canada] ; Julia A. Knight [Canada] ; Peter Devilee [Pays-Bas] ; Caroline Seynaeve [Pays-Bas] ; Jonine Figueroa [États-Unis] ; Mark E. Sherman [États-Unis] ; Kamila Czene [Suède] ; Hatef Darabi [Suède] ; Antoinette Hollestelle [Pays-Bas] ; Ans M W. Van Den Ouweland [Pays-Bas] ; Keith Humphreys [Suède] ; Yu-Tang Gao [République populaire de Chine] ; Xiao-Ou Shu [États-Unis] ; Angela Cox [Royaume-Uni] ; Simon S. Cross [Royaume-Uni] ; William Blot [États-Unis] ; Qiuyin Cai [États-Unis] ; Maya Ghoussaini [Royaume-Uni] ; Barbara J. Perkins [Royaume-Uni] ; Mitul Shah [Royaume-Uni] ; Ji-Yeob Choi [Corée du Sud] ; Daehee Kang [Corée du Sud] ; Soo Chin Lee [Singapour] ; Mikael Hartman [Singapour] ; Maria Kabisch [Allemagne] ; Diana Torres [Allemagne, Colombie] ; Anna Jakubowska [Pologne] ; Jan Lubinski [Pologne] ; Paul Brennan [France] ; Suleeporn Sangrajrang [Thaïlande] ; Christine B. Ambrosone [États-Unis] ; Amanda E. Toland [États-Unis] ; Chen-Yang Shen [Taïwan] ; Pei-Ei Wu [Taïwan] ; Nick Orr [Royaume-Uni] ; Anthony Swerdlow [Royaume-Uni] ; Lesley Mcguffog [Royaume-Uni] ; Sue Healey [Australie] ; Andrew Lee [Royaume-Uni] ; Miroslav Kapuscinski [Australie] ; Esther M. John [États-Unis] ; Mary Beth Terry [États-Unis] ; Mary B. Daly [États-Unis] ; David E. Goldgar [États-Unis] ; Saundra S. Buys [États-Unis] ; Ramunas Janavicius [Lituanie] ; Laima Tihomirova [Lettonie] ; Nadine Tung [États-Unis] ; Cecilia M. Dorfling [Afrique du Sud] ; Elizabeth J. Van Rensburg [Afrique du Sud] ; Susan L. Neuhausen [États-Unis] ; Bent Ejlertsen [Danemark] ; Thomas V O. Hansen [Danemark] ; Ana Osorio [Espagne] ; Javier Benitez [Espagne] ; Rachel Rando [États-Unis] ; Jeffrey N. Weitzel [États-Unis] ; Bernardo Bonanni [Italie] ; Bernard Peissel [Italie] ; Siranoush Manoukian [Italie] ; Laura Papi [Italie] ; Laura Ottini [Italie] ; Irene Konstantopoulou [Grèce] ; Paraskevi Apostolou [Grèce] ; Judy Garber [États-Unis] ; Muhammad Usman Rashid [Allemagne, Pakistan] ; Debra Frost [Royaume-Uni] ; Louise Izatt [Royaume-Uni] ; Steve Ellis [Royaume-Uni] ; Andrew K. Godwin [États-Unis] ; Norbert Arnold [Allemagne] ; Dieter Niederacher [Allemagne] ; Kerstin Rhiem [Allemagne] ; Nadja Bogdanova-Markov [Allemagne] ; Charlotte Sagne [France] ; Dominique Stoppa-Lyonnet [France] ; Francesca Damiola [France] ; Olga M. Sinilnikova [France] ; Sylvie Mazoyer [France] ; Claudine Isaacs [États-Unis] ; Kathleen B M. Claes [Belgique] ; Kim De Leeneer [Belgique] ; Miguel De La Hoya [Espagne] ; Trinidad Caldes [Espagne] ; Heli Nevanlinna [Finlande] ; Sofia Khan [Finlande] ; Arjen R. Mensenkamp [Pays-Bas] ; Maartje J. Hooning [Pays-Bas] ; Matti A. Rookus [Pays-Bas] ; Ava Kwong [Hong Kong] ; Edith Olah [Hongrie] ; Orland Diez [Espagne] ; Joan Brunet [Espagne] ; Miquel Angel Pujana [Espagne] ; Jacek Gronwald [Pologne] ; Tomasz Huzarski [Pologne] ; Rosa B. Barkardottir [Islande] ; Rachel Laframboise [Canada] ; Penny Soucy [Canada] ; Marco Montagna [Italie] ; Simona Agata [Italie] ; Manuel R. Teixeira [Portugal] ; Sue Kyung Park [Corée du Sud] ; Noralane Lindor [États-Unis] ; Fergus J. Couch [États-Unis] ; Marc Tischkowitz [Canada] ; Lenka Foretova [République tchèque] ; Joseph Vijai [États-Unis] ; Kenneth Offit [États-Unis] ; Christian F. Singer [Autriche] ; Christine Rappaport [Autriche] ; Catherine M. Phelan [États-Unis] ; Mark H. Greene [États-Unis] ; Phuong L. Mai [États-Unis] ; Gad Rennert [Israël] ; Evgeny N. Imyanitov [Russie] ; Peter J. Hulick [États-Unis] ; Kelly-Anne Phillips [Australie] ; Marion Piedmonte [États-Unis] ; Anna Marie Mulligan [Canada] ; Gord Glendon [Canada] ; Anders Bojesen [Danemark] ; Mads Thomassen [Danemark] ; Maria A. Caligo [Italie] ; Sook-Yee Yoon [Malaisie] ; Eitan Friedman [Israël] ; Yael Laitman [Israël] ; Ake Borg [Suède] ; Anna Von Wachenfeldt [Suède] ; Hans Ehrencrona [Suède] ; Johanna Rantala [Suède] ; Olufunmilayo I. Olopade [États-Unis] ; Patricia A. Ganz [États-Unis] ; Robert L. Nussbaum [États-Unis] ; Simon A. Gayther [États-Unis] ; Katherine L. Nathanson [États-Unis] ; Susan M. Domchek [États-Unis] ; Banu K. Arun [États-Unis] ; Gillian Mitchell [Australie] ; Beth Y. Karlan [États-Unis] ; Jenny Lester [États-Unis] ; Gertraud Maskarinec [États-Unis] ; Christy Woolcott [Canada] ; Christopher Scott [États-Unis] ; Jennifer Stone [Australie] ; Carmel Apicella [Australie] ; Rulla Tamimi [États-Unis] ; Robert Luben [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Slaug Helland [Norvège] ; Vilde Haakensen [Norvège] ; Mitch Dowsett [Royaume-Uni] ; Paul D P. Pharoah [Royaume-Uni] ; Jacques Simard [Canada] ; Per Hall [Suède] ; Montserrat García-Closas [Royaume-Uni] ; Celine Vachon [États-Unis] ; Georgia Chenevix-Trench [Australie] ; Antonis C. Antoniou [Royaume-Uni] ; Douglas F. Easton [Royaume-Uni] ; Stacey L. Edwards [Australie]Source :
- Nature genetics [ 1061-4036 ] ; 2016.
Abstract
We analyzed 3,872 common genetic variants across the
Url:
DOI: 10.1038/ng.3521
PubMed: 26928228
PubMed Central: 4938803
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PMC:4938803Le document en format XML
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Pooley</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Knowles, Elena" sort="Lopez Knowles, Elena" uniqKey="Lopez Knowles E" first="Elena" last="Lopez-Knowles">Elena Lopez-Knowles</name><affiliation wicri:level="1"><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Sinnott Armstrong, Nicholas A" sort="Sinnott Armstrong, Nicholas A" uniqKey="Sinnott Armstrong N" first="Nicholas A" last="Sinnott-Armstrong">Nicholas A. Sinnott-Armstrong</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Genetics, Stanford University School of Medicine, Stanford, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Sallari, Richard C" sort="Sallari, Richard C" uniqKey="Sallari R" first="Richard C" last="Sallari">Richard C. Sallari</name><affiliation wicri:level="1"><nlm:aff id="A7">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hillman, Kristine M" sort="Hillman, Kristine M" uniqKey="Hillman K" first="Kristine M" last="Hillman">Kristine M. Hillman</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Kaufmann, Susanne" sort="Kaufmann, Susanne" uniqKey="Kaufmann S" first="Susanne" last="Kaufmann">Susanne Kaufmann</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Sivakumaran, Haran" sort="Sivakumaran, Haran" uniqKey="Sivakumaran H" first="Haran" last="Sivakumaran">Haran Sivakumaran</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Marjaneh, Mahdi Moradi" sort="Marjaneh, Mahdi Moradi" uniqKey="Marjaneh M" first="Mahdi Moradi" last="Marjaneh">Mahdi Moradi Marjaneh</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Hills, Margaret" sort="Hills, Margaret" uniqKey="Hills M" first="Margaret" last="Hills">Margaret Hills</name><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Jarosz, Monika" sort="Jarosz, Monika" uniqKey="Jarosz M" first="Monika" last="Jarosz">Monika Jarosz</name><affiliation wicri:level="1"><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Drury, Suzie" sort="Drury, Suzie" uniqKey="Drury S" first="Suzie" last="Drury">Suzie Drury</name><affiliation wicri:level="1"><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation wicri:level="1"><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation wicri:level="1"><nlm:aff id="A11">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry</wicri:regionArea></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="A11">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Population Health, University of Manchester, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J" last="Sawyer">Elinor J. Sawyer</name><affiliation wicri:level="1"><nlm:aff id="A16">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="A17">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="1"><nlm:aff id="A19">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A20">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="1"><nlm:aff id="A21">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A22">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="A23">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">University Paris–Sud, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris–Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="A23">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">University Paris–Sud, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris–Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="1"><nlm:aff id="A25">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A27">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:aff id="A29">Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Perez, Jose I A" sort="Perez, Jose I A" uniqKey="Perez J" first="Jose I A" last="Perez">Jose I A. Perez</name><affiliation wicri:level="1"><nlm:aff id="A30">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo</wicri:regionArea></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="A31">Department of Epidemiology, University of California–Irvine, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of California–Irvine, Irvine, California</wicri:regionArea></affiliation></author><author><name sortKey="Eunjung, Lee" sort="Eunjung, Lee" uniqKey="Eunjung L" first="Lee" last="Eunjung">Lee Eunjung</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="1"><nlm:aff id="A33">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="A33">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A34">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, Technical University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A36">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Center for Integrated Oncology, University Hospital, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Integrated Oncology, University Hospital, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="1"><nlm:aff id="A34">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="1"><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="A42">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation wicri:level="1"><nlm:aff id="A44">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi</wicri:regionArea></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation wicri:level="1"><nlm:aff id="A45">Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova, Natasha" sort="Bogdanova, Natasha" uniqKey="Bogdanova N" first="Natasha" last="Bogdanova">Natasha Bogdanova</name><affiliation wicri:level="1"><nlm:aff id="A46">Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Radiation Oncology Research Unit, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation wicri:level="1"><nlm:aff id="A47">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gynaecology Research Unit, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation wicri:level="1"><nlm:aff id="A48">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology-Pathology, Karolinska University Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="A50">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cancer Center, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="A50">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cancer Center, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="A53">Vesalius Research Center, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center, Leuven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation wicri:level="1"><nlm:aff id="A55">Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="A56">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation wicri:level="1"><nlm:aff id="A56">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="A58">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation wicri:level="1"><nlm:aff id="A59">Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S" last="Goldberg">Mark S. Goldberg</name><affiliation wicri:level="1"><nlm:aff id="A62">Department of Medicine, McGill University, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McGill University, Montreal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A63">Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Soo H" sort="Teo, Soo H" uniqKey="Teo S" first="Soo H" last="Teo">Soo H. Teo</name><affiliation wicri:level="1"><nlm:aff id="A64">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation wicri:level="1"><nlm:aff id="A65">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Institute of Clinical Medicine, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Institute of Clinical Medicine, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A68">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="A70">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="A70">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="A72">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A73">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><affiliation wicri:level="1"><nlm:aff id="A74">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A75">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><nlm:aff id="A76">Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation wicri:level="1"><nlm:aff id="A78">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A79">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E" last="Sherman">Mark E. Sherman</name><affiliation wicri:level="1"><nlm:aff id="A79">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation wicri:level="1"><nlm:aff id="A78">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M W" last="Van Den Ouweland">Ans M W. Van Den Ouweland</name><affiliation wicri:level="1"><nlm:aff id="A81">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation wicri:level="1"><nlm:aff id="A82">Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:aff id="A83">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name><affiliation wicri:level="1"><nlm:aff id="A84">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A85">International Epidemiology Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Epidemiology Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J" last="Perkins">Barbara J. Perkins</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation wicri:level="1"><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation wicri:level="1"><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Soo Chin" sort="Lee, Soo Chin" uniqKey="Lee S" first="Soo Chin" last="Lee">Soo Chin Lee</name><affiliation wicri:level="1"><nlm:aff id="A89">Department of Haematology-Oncology, National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Haematology-Oncology, National University Health System</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A90">Cancer Science Institute of Singapore, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Cancer Science Institute of Singapore, National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation wicri:level="1"><nlm:aff id="A91">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A92">Department of Surgery, National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Surgery, National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation wicri:level="1"><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation wicri:level="1"><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A93">Institute of Human Genetics, Pontificia Universidad Javerianar, Bogota, Colombia</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Institute of Human Genetics, Pontificia Universidad Javerianar, Bogota</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="1"><nlm:aff id="A95">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation wicri:level="1"><nlm:aff id="A96">National Cancer Institute, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>National Cancer Institute, Bangkok</wicri:regionArea></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B" last="Ambrosone">Christine B. Ambrosone</name><affiliation wicri:level="1"><nlm:aff id="A97">Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roswell Park Cancer Institute, Buffalo, New York</wicri:regionArea></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name><affiliation wicri:level="1"><nlm:aff id="A98">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation wicri:level="1"><nlm:aff id="A99">School of Public Health, China Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Public Health, China Medical University, Taichung</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A100">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation wicri:level="1"><nlm:aff id="A100">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation wicri:level="1"><nlm:aff id="A101">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="A102">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A103">Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Breast Cancer Research, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Kapuscinski, Miroslav" sort="Kapuscinski, Miroslav" uniqKey="Kapuscinski M" first="Miroslav" last="Kapuscinski">Miroslav Kapuscinski</name><affiliation wicri:level="1"><nlm:aff id="A104">Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation wicri:level="1"><nlm:aff id="A105">Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California</wicri:regionArea></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation wicri:level="1"><nlm:aff id="A106">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name><affiliation wicri:level="1"><nlm:aff id="A107">Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation wicri:level="1"><nlm:aff id="A108">Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah</wicri:regionArea></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name><affiliation wicri:level="1"><nlm:aff id="A109">Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah</wicri:regionArea></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation wicri:level="1"><nlm:aff id="A110">State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>State Research Institute Centre for Innovative Medicine, Vilnius</wicri:regionArea></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation wicri:level="1"><nlm:aff id="A111">Latvian Biomedical Research and Study Centre, Riga, Latvia</nlm:aff><country xml:lang="fr">Lettonie</country><wicri:regionArea>Latvian Biomedical Research and Study Centre, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation wicri:level="1"><nlm:aff id="A112">Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M" last="Dorfling">Cecilia M. Dorfling</name><affiliation wicri:level="1"><nlm:aff id="A113">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Genetics, University of Pretoria, Pretoria</wicri:regionArea></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J" last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation wicri:level="1"><nlm:aff id="A113">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Genetics, University of Pretoria, Pretoria</wicri:regionArea></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name><affiliation wicri:level="1"><nlm:aff id="A114">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California</wicri:regionArea></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation wicri:level="1"><nlm:aff id="A115">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name><affiliation wicri:level="1"><nlm:aff id="A116">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation wicri:level="1"><nlm:aff id="A117">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A118">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Biomedical Network on Rare Diseases (CIBERER), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="A117">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A118">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Biomedical Network on Rare Diseases (CIBERER), Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A119">Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Rando, Rachel" sort="Rando, Rachel" uniqKey="Rando R" first="Rachel" last="Rando">Rachel Rando</name><affiliation wicri:level="1"><nlm:aff id="A120">City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California</wicri:regionArea></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name><affiliation wicri:level="1"><nlm:aff id="A121">Clinical Cancer Genetics, City of Hope, Duarte, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Cancer Genetics, City of Hope, Duarte, California</wicri:regionArea></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation wicri:level="1"><nlm:aff id="A122">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation wicri:level="1"><nlm:aff id="A123">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation wicri:level="1"><nlm:aff id="A123">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation wicri:level="1"><nlm:aff id="A124">Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence</wicri:regionArea></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation wicri:level="1"><nlm:aff id="A125">Department of Molecular Medicine, University La Sapienza, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Molecular Medicine, University La Sapienza, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation wicri:level="1"><nlm:aff id="A126">Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Apostolou, Paraskevi" sort="Apostolou, Paraskevi" uniqKey="Apostolou P" first="Paraskevi" last="Apostolou">Paraskevi Apostolou</name><affiliation wicri:level="1"><nlm:aff id="A126">Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation wicri:level="1"><nlm:aff id="A127">Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Rashid, Muhammad Usman" sort="Rashid, Muhammad Usman" uniqKey="Rashid M" first="Muhammad Usman" last="Rashid">Muhammad Usman Rashid</name><affiliation wicri:level="1"><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A128">Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore</wicri:regionArea></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation wicri:level="1"><nlm:aff id="A129">Clinical Genetics, Guy’s and St. Thomas’ National Health Service (NHS) Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Genetics, Guy’s and St. Thomas’ National Health Service (NHS) Foundation Trust, London</wicri:regionArea></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name><affiliation wicri:level="1"><nlm:aff id="A130">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation wicri:level="1"><nlm:aff id="A131">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation wicri:level="1"><nlm:aff id="A132">University Düsseldorf, Dusseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Düsseldorf, Dusseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Rhiem, Kerstin" sort="Rhiem, Kerstin" uniqKey="Rhiem K" first="Kerstin" last="Rhiem">Kerstin Rhiem</name><affiliation wicri:level="1"><nlm:aff id="A133">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova Markov, Nadja" sort="Bogdanova Markov, Nadja" uniqKey="Bogdanova Markov N" first="Nadja" last="Bogdanova-Markov">Nadja Bogdanova-Markov</name><affiliation wicri:level="1"><nlm:aff id="A134">Institute of Human Genetics, Münster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Münster</wicri:regionArea></affiliation></author><author><name sortKey="Sagne, Charlotte" sort="Sagne, Charlotte" uniqKey="Sagne C" first="Charlotte" last="Sagne">Charlotte Sagne</name><affiliation wicri:level="1"><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="A136">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, Department of Tumour Biology, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A137">Université Paris Descartes, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation wicri:level="1"><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M" last="Sinilnikova">Olga M. Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A138">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation wicri:level="1"><nlm:aff id="A139">Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC</wicri:regionArea></affiliation></author><author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B M" last="Claes">Kathleen B M. Claes</name><affiliation wicri:level="1"><nlm:aff id="A140">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="De Leeneer, Kim" sort="De Leeneer, Kim" uniqKey="De Leeneer K" first="Kim" last="De Leeneer">Kim De Leeneer</name><affiliation wicri:level="1"><nlm:aff id="A140">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation wicri:level="1"><nlm:aff id="A141">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation wicri:level="1"><nlm:aff id="A141">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A142">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation wicri:level="1"><nlm:aff id="A142">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Mensenkamp, Arjen R" sort="Mensenkamp, Arjen R" uniqKey="Mensenkamp A" first="Arjen R" last="Mensenkamp">Arjen R. Mensenkamp</name><affiliation wicri:level="1"><nlm:aff id="A143">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J" last="Hooning">Maartje J. Hooning</name><affiliation wicri:level="1"><nlm:aff id="A144">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name><affiliation wicri:level="1"><nlm:aff id="A145">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation wicri:level="1"><nlm:aff id="A146">Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A147">Department of Surgery, University of Hong Kong, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Surgery, University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation wicri:level="1"><nlm:aff id="A148">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Molecular Genetics, National Institute of Oncology, Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation wicri:level="1"><nlm:aff id="A149">Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation wicri:level="1"><nlm:aff id="A150">Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona</wicri:regionArea></affiliation></author><author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name><affiliation wicri:level="1"><nlm:aff id="A151">Breast Cancer and Systems Biology Unit, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Unit, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B" last="Barkardottir">Rosa B. Barkardottir</name><affiliation wicri:level="1"><nlm:aff id="A152">Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Laframboise, Rachel" sort="Laframboise, Rachel" uniqKey="Laframboise R" first="Rachel" last="Laframboise">Rachel Laframboise</name><affiliation wicri:level="1"><nlm:aff id="A153">Medical Genetic Division, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Medical Genetic Division, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation wicri:level="1"><nlm:aff id="A154">Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation wicri:level="1"><nlm:aff id="A155">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua</wicri:regionArea></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation wicri:level="1"><nlm:aff id="A155">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua</wicri:regionArea></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name><affiliation wicri:level="1"><nlm:aff id="A156">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Genetics, Portuguese Oncology Institute, Porto</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A157">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Biomedical Sciences Institute (ICBAS), Porto University, Porto</wicri:regionArea></affiliation></author><author><name sortKey="Park, Sue Kyung" sort="Park, Sue Kyung" uniqKey="Park S" first="Sue Kyung" last="Park">Sue Kyung Park</name><affiliation wicri:level="1"><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A158">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation wicri:level="1"><nlm:aff id="A159">Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Cancer Genetics, McGill University, Montreal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation wicri:level="1"><nlm:aff id="A160">Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno</wicri:regionArea></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation wicri:level="1"><nlm:aff id="A161">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation wicri:level="1"><nlm:aff id="A161">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name><affiliation wicri:level="1"><nlm:aff id="A162">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation wicri:level="1"><nlm:aff id="A162">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name><affiliation wicri:level="1"><nlm:aff id="A163">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida</wicri:regionArea></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name><affiliation wicri:level="1"><nlm:aff id="A164">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name><affiliation wicri:level="1"><nlm:aff id="A164">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="1"><nlm:aff id="A165">Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A166">Clalit National Israeli Cancer Control Center, Haifa, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit National Israeli Cancer Control Center, Haifa</wicri:regionArea></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N" last="Imyanitov">Evgeny N. Imyanitov</name><affiliation wicri:level="1"><nlm:aff id="A167">N.N. Petrov Institute of Oncology, St. Petersburg, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>N.N. Petrov Institute of Oncology, St. Petersburg</wicri:regionArea></affiliation></author><author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J" last="Hulick">Peter J. Hulick</name><affiliation wicri:level="1"><nlm:aff id="A168">Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation wicri:level="1"><nlm:aff id="A169">Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation wicri:level="1"><nlm:aff id="A170">NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York</wicri:regionArea></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation wicri:level="1"><nlm:aff id="A171">Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine Program, University Health Network, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A172">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation wicri:level="1"><nlm:aff id="A72">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name><affiliation wicri:level="1"><nlm:aff id="A173">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Genetics, Vejle Hospital, Vejle</wicri:regionArea></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation wicri:level="1"><nlm:aff id="A174">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Genetics, Odense University Hospital, Odense</wicri:regionArea></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name><affiliation wicri:level="1"><nlm:aff id="A175">Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Yoon, Sook Yee" sort="Yoon, Sook Yee" uniqKey="Yoon S" first="Sook-Yee" last="Yoon">Sook-Yee Yoon</name><affiliation wicri:level="1"><nlm:aff id="A64">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A176">University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation wicri:level="1"><nlm:aff id="A177">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation wicri:level="1"><nlm:aff id="A177">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name><affiliation wicri:level="1"><nlm:aff id="A178">Department of Oncology, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Von Wachenfeldt, Anna" sort="Von Wachenfeldt, Anna" uniqKey="Von Wachenfeldt A" first="Anna" last="Von Wachenfeldt">Anna Von Wachenfeldt</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology-Pathology, Karolinska University Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation wicri:level="1"><nlm:aff id="A179">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A180">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Genetics, Lund University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation wicri:level="1"><nlm:aff id="A181">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Genetics, Karolinska University Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I" last="Olopade">Olufunmilayo I. Olopade</name><affiliation wicri:level="1"><nlm:aff id="A182">Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A" last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="1"><nlm:aff id="A183">Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine and School of Public Health, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine and School of Public Health, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L" last="Nussbaum">Robert L. Nussbaum</name><affiliation wicri:level="1"><nlm:aff id="A184">Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="1"><nlm:aff id="A185">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name><affiliation wicri:level="1"><nlm:aff id="A185">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K" last="Arun">Banu K. Arun</name><affiliation wicri:level="1"><nlm:aff id="A186">University of Texas MD Anderson Cancer Center, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Gillian" sort="Mitchell, Gillian" uniqKey="Mitchell G" first="Gillian" last="Mitchell">Gillian Mitchell</name><affiliation wicri:level="1"><nlm:aff id="A187">Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A188">Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><affiliation wicri:level="1"><nlm:aff id="A189">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation wicri:level="1"><nlm:aff id="A189">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name><affiliation wicri:level="1"><nlm:aff id="A190">University of Hawaii Cancer Center, Honolulu, Hawaii, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name><affiliation wicri:level="1"><nlm:aff id="A191">Department of Obstetrics, Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Obstetrics, Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Christopher" sort="Scott, Christopher" uniqKey="Scott C" first="Christopher" last="Scott">Christopher Scott</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation wicri:level="1"><nlm:aff id="A192">Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia</wicri:regionArea></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation wicri:level="1"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation wicri:level="1"><nlm:aff id="A193">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A194">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A195">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation wicri:level="1"><nlm:aff id="A196">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A196">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Haakensen, Vilde" sort="Haakensen, Vilde" uniqKey="Haakensen V" first="Vilde" last="Haakensen">Vilde Haakensen</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Dowsett, Mitch" sort="Dowsett, Mitch" uniqKey="Dowsett M" first="Mitch" last="Dowsett">Mitch Dowsett</name><affiliation wicri:level="1"><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D P" last="Pharoah">Paul D P. Pharoah</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="A154">Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation wicri:level="1"><nlm:aff id="A101">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A102">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L" last="Edwards">Stacey L. Edwards</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26928228</idno><idno type="pmc">4938803</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938803</idno><idno type="RBID">PMC:4938803</idno><idno type="doi">10.1038/ng.3521</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002152</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002152</idno><idno type="wicri:Area/Pmc/Curation">002004</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002004</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Breast cancer risk variants at 6q25 display different phenotype
associations and regulate <italic>ESR1</italic>, <italic>RMND1</italic> and
<italic>CCDC170</italic></title><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M" last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D" last="French">Juliet D. French</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S" last="Healey">Catherine S. Healey</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A" last="Pooley">Karen A. Pooley</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Knowles, Elena" sort="Lopez Knowles, Elena" uniqKey="Lopez Knowles E" first="Elena" last="Lopez-Knowles">Elena Lopez-Knowles</name><affiliation wicri:level="1"><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Dicks, Ed" sort="Dicks, Ed" uniqKey="Dicks E" first="Ed" last="Dicks">Ed Dicks</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Sinnott Armstrong, Nicholas A" sort="Sinnott Armstrong, Nicholas A" uniqKey="Sinnott Armstrong N" first="Nicholas A" last="Sinnott-Armstrong">Nicholas A. Sinnott-Armstrong</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Genetics, Stanford University School of Medicine, Stanford, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Sallari, Richard C" sort="Sallari, Richard C" uniqKey="Sallari R" first="Richard C" last="Sallari">Richard C. Sallari</name><affiliation wicri:level="1"><nlm:aff id="A7">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Hillman, Kristine M" sort="Hillman, Kristine M" uniqKey="Hillman K" first="Kristine M" last="Hillman">Kristine M. Hillman</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Kaufmann, Susanne" sort="Kaufmann, Susanne" uniqKey="Kaufmann S" first="Susanne" last="Kaufmann">Susanne Kaufmann</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Sivakumaran, Haran" sort="Sivakumaran, Haran" uniqKey="Sivakumaran H" first="Haran" last="Sivakumaran">Haran Sivakumaran</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Marjaneh, Mahdi Moradi" sort="Marjaneh, Mahdi Moradi" uniqKey="Marjaneh M" first="Mahdi Moradi" last="Marjaneh">Mahdi Moradi Marjaneh</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Hills, Margaret" sort="Hills, Margaret" uniqKey="Hills M" first="Margaret" last="Hills">Margaret Hills</name><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Jarosz, Monika" sort="Jarosz, Monika" uniqKey="Jarosz M" first="Monika" last="Jarosz">Monika Jarosz</name><affiliation wicri:level="1"><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Drury, Suzie" sort="Drury, Suzie" uniqKey="Drury S" first="Suzie" last="Drury">Suzie Drury</name><affiliation wicri:level="1"><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation wicri:level="1"><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation wicri:level="1"><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A8">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation wicri:level="1"><nlm:aff id="A11">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry</wicri:regionArea></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="A11">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Population Health, University of Manchester, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J" last="Sawyer">Elinor J. Sawyer</name><affiliation wicri:level="1"><nlm:aff id="A16">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="A17">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="1"><nlm:aff id="A19">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A20">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="1"><nlm:aff id="A21">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A22">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="A23">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">University Paris–Sud, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris–Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="A23">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">University Paris–Sud, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris–Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="1"><nlm:aff id="A25">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A27">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:aff id="A29">Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Perez, Jose I A" sort="Perez, Jose I A" uniqKey="Perez J" first="Jose I A" last="Perez">Jose I A. Perez</name><affiliation wicri:level="1"><nlm:aff id="A30">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo</wicri:regionArea></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation wicri:level="1"><nlm:aff id="A31">Department of Epidemiology, University of California–Irvine, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of California–Irvine, Irvine, California</wicri:regionArea></affiliation></author><author><name sortKey="Eunjung, Lee" sort="Eunjung, Lee" uniqKey="Eunjung L" first="Lee" last="Eunjung">Lee Eunjung</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="1"><nlm:aff id="A33">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="A33">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A34">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="A35">Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, Technical University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A36">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Center for Integrated Oncology, University Hospital, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Integrated Oncology, University Hospital, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="1"><nlm:aff id="A34">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="1"><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="A42">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation wicri:level="1"><nlm:aff id="A44">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi</wicri:regionArea></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation wicri:level="1"><nlm:aff id="A45">Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova, Natasha" sort="Bogdanova, Natasha" uniqKey="Bogdanova N" first="Natasha" last="Bogdanova">Natasha Bogdanova</name><affiliation wicri:level="1"><nlm:aff id="A46">Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Radiation Oncology Research Unit, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation wicri:level="1"><nlm:aff id="A47">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gynaecology Research Unit, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation wicri:level="1"><nlm:aff id="A48">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology-Pathology, Karolinska University Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="A50">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cancer Center, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="A50">Cancer Center, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cancer Center, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="A53">Vesalius Research Center, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center, Leuven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation wicri:level="1"><nlm:aff id="A55">Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="A56">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation wicri:level="1"><nlm:aff id="A56">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="A58">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation wicri:level="1"><nlm:aff id="A59">Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E" last="Olson">Janet E. Olson</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S" last="Goldberg">Mark S. Goldberg</name><affiliation wicri:level="1"><nlm:aff id="A62">Department of Medicine, McGill University, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McGill University, Montreal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A63">Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Soo H" sort="Teo, Soo H" uniqKey="Teo S" first="Soo H" last="Teo">Soo H. Teo</name><affiliation wicri:level="1"><nlm:aff id="A64">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A65">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation wicri:level="1"><nlm:aff id="A65">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Institute of Clinical Medicine, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Institute of Clinical Medicine, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A68">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="A70">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="A70">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="A72">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A73">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name><affiliation wicri:level="1"><nlm:aff id="A74">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A75">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><nlm:aff id="A76">Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation wicri:level="1"><nlm:aff id="A78">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A79">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E" last="Sherman">Mark E. Sherman</name><affiliation wicri:level="1"><nlm:aff id="A79">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation wicri:level="1"><nlm:aff id="A78">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M W" last="Van Den Ouweland">Ans M W. Van Den Ouweland</name><affiliation wicri:level="1"><nlm:aff id="A81">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation wicri:level="1"><nlm:aff id="A82">Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:aff id="A83">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name><affiliation wicri:level="1"><nlm:aff id="A84">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A85">International Epidemiology Institute, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Epidemiology Institute, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation wicri:level="1"><nlm:aff id="A69">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J" last="Perkins">Barbara J. Perkins</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation wicri:level="1"><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation wicri:level="1"><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Soo Chin" sort="Lee, Soo Chin" uniqKey="Lee S" first="Soo Chin" last="Lee">Soo Chin Lee</name><affiliation wicri:level="1"><nlm:aff id="A89">Department of Haematology-Oncology, National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Haematology-Oncology, National University Health System</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A90">Cancer Science Institute of Singapore, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Cancer Science Institute of Singapore, National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation wicri:level="1"><nlm:aff id="A91">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A92">Department of Surgery, National University Health System, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Surgery, National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation wicri:level="1"><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation wicri:level="1"><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A93">Institute of Human Genetics, Pontificia Universidad Javerianar, Bogota, Colombia</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Institute of Human Genetics, Pontificia Universidad Javerianar, Bogota</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="1"><nlm:aff id="A95">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation wicri:level="1"><nlm:aff id="A96">National Cancer Institute, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>National Cancer Institute, Bangkok</wicri:regionArea></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B" last="Ambrosone">Christine B. Ambrosone</name><affiliation wicri:level="1"><nlm:aff id="A97">Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roswell Park Cancer Institute, Buffalo, New York</wicri:regionArea></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E" last="Toland">Amanda E. Toland</name><affiliation wicri:level="1"><nlm:aff id="A98">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation wicri:level="1"><nlm:aff id="A99">School of Public Health, China Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Public Health, China Medical University, Taichung</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A100">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation wicri:level="1"><nlm:aff id="A100">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation wicri:level="1"><nlm:aff id="A101">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="A102">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A103">Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Breast Cancer Research, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Kapuscinski, Miroslav" sort="Kapuscinski, Miroslav" uniqKey="Kapuscinski M" first="Miroslav" last="Kapuscinski">Miroslav Kapuscinski</name><affiliation wicri:level="1"><nlm:aff id="A104">Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation wicri:level="1"><nlm:aff id="A105">Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California</wicri:regionArea></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation wicri:level="1"><nlm:aff id="A106">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name><affiliation wicri:level="1"><nlm:aff id="A107">Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation wicri:level="1"><nlm:aff id="A108">Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah</wicri:regionArea></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S" last="Buys">Saundra S. Buys</name><affiliation wicri:level="1"><nlm:aff id="A109">Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah</wicri:regionArea></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation wicri:level="1"><nlm:aff id="A110">State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>State Research Institute Centre for Innovative Medicine, Vilnius</wicri:regionArea></affiliation></author><author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name><affiliation wicri:level="1"><nlm:aff id="A111">Latvian Biomedical Research and Study Centre, Riga, Latvia</nlm:aff><country xml:lang="fr">Lettonie</country><wicri:regionArea>Latvian Biomedical Research and Study Centre, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation wicri:level="1"><nlm:aff id="A112">Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M" last="Dorfling">Cecilia M. Dorfling</name><affiliation wicri:level="1"><nlm:aff id="A113">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Genetics, University of Pretoria, Pretoria</wicri:regionArea></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J" last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation wicri:level="1"><nlm:aff id="A113">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Genetics, University of Pretoria, Pretoria</wicri:regionArea></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name><affiliation wicri:level="1"><nlm:aff id="A114">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California</wicri:regionArea></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation wicri:level="1"><nlm:aff id="A115">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name><affiliation wicri:level="1"><nlm:aff id="A116">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation wicri:level="1"><nlm:aff id="A117">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A118">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Biomedical Network on Rare Diseases (CIBERER), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="A117">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A118">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Biomedical Network on Rare Diseases (CIBERER), Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A119">Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Rando, Rachel" sort="Rando, Rachel" uniqKey="Rando R" first="Rachel" last="Rando">Rachel Rando</name><affiliation wicri:level="1"><nlm:aff id="A120">City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California</wicri:regionArea></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name><affiliation wicri:level="1"><nlm:aff id="A121">Clinical Cancer Genetics, City of Hope, Duarte, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Cancer Genetics, City of Hope, Duarte, California</wicri:regionArea></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation wicri:level="1"><nlm:aff id="A122">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation wicri:level="1"><nlm:aff id="A123">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation wicri:level="1"><nlm:aff id="A123">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation wicri:level="1"><nlm:aff id="A124">Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence</wicri:regionArea></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation wicri:level="1"><nlm:aff id="A125">Department of Molecular Medicine, University La Sapienza, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Molecular Medicine, University La Sapienza, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation wicri:level="1"><nlm:aff id="A126">Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Apostolou, Paraskevi" sort="Apostolou, Paraskevi" uniqKey="Apostolou P" first="Paraskevi" last="Apostolou">Paraskevi Apostolou</name><affiliation wicri:level="1"><nlm:aff id="A126">Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation wicri:level="1"><nlm:aff id="A127">Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Rashid, Muhammad Usman" sort="Rashid, Muhammad Usman" uniqKey="Rashid M" first="Muhammad Usman" last="Rashid">Muhammad Usman Rashid</name><affiliation wicri:level="1"><nlm:aff id="A41">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A128">Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore</wicri:regionArea></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation wicri:level="1"><nlm:aff id="A129">Clinical Genetics, Guy’s and St. Thomas’ National Health Service (NHS) Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Genetics, Guy’s and St. Thomas’ National Health Service (NHS) Foundation Trust, London</wicri:regionArea></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name><affiliation wicri:level="1"><nlm:aff id="A130">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation wicri:level="1"><nlm:aff id="A131">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation wicri:level="1"><nlm:aff id="A132">University Düsseldorf, Dusseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Düsseldorf, Dusseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Rhiem, Kerstin" sort="Rhiem, Kerstin" uniqKey="Rhiem K" first="Kerstin" last="Rhiem">Kerstin Rhiem</name><affiliation wicri:level="1"><nlm:aff id="A133">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova Markov, Nadja" sort="Bogdanova Markov, Nadja" uniqKey="Bogdanova Markov N" first="Nadja" last="Bogdanova-Markov">Nadja Bogdanova-Markov</name><affiliation wicri:level="1"><nlm:aff id="A134">Institute of Human Genetics, Münster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Münster</wicri:regionArea></affiliation></author><author><name sortKey="Sagne, Charlotte" sort="Sagne, Charlotte" uniqKey="Sagne C" first="Charlotte" last="Sagne">Charlotte Sagne</name><affiliation wicri:level="1"><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="A136">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, Department of Tumour Biology, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A137">Université Paris Descartes, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation wicri:level="1"><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M" last="Sinilnikova">Olga M. Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A138">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="A135">INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation wicri:level="1"><nlm:aff id="A139">Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC</wicri:regionArea></affiliation></author><author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B M" last="Claes">Kathleen B M. Claes</name><affiliation wicri:level="1"><nlm:aff id="A140">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="De Leeneer, Kim" sort="De Leeneer, Kim" uniqKey="De Leeneer K" first="Kim" last="De Leeneer">Kim De Leeneer</name><affiliation wicri:level="1"><nlm:aff id="A140">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation wicri:level="1"><nlm:aff id="A141">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation wicri:level="1"><nlm:aff id="A141">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A142">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation wicri:level="1"><nlm:aff id="A142">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Mensenkamp, Arjen R" sort="Mensenkamp, Arjen R" uniqKey="Mensenkamp A" first="Arjen R" last="Mensenkamp">Arjen R. Mensenkamp</name><affiliation wicri:level="1"><nlm:aff id="A143">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J" last="Hooning">Maartje J. Hooning</name><affiliation wicri:level="1"><nlm:aff id="A144">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name><affiliation wicri:level="1"><nlm:aff id="A145">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation wicri:level="1"><nlm:aff id="A146">Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A147">Department of Surgery, University of Hong Kong, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Surgery, University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation wicri:level="1"><nlm:aff id="A148">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Molecular Genetics, National Institute of Oncology, Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation wicri:level="1"><nlm:aff id="A149">Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation wicri:level="1"><nlm:aff id="A150">Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona</wicri:regionArea></affiliation></author><author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name><affiliation wicri:level="1"><nlm:aff id="A151">Breast Cancer and Systems Biology Unit, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Unit, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation wicri:level="1"><nlm:aff id="A94">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Barkardottir, Rosa B" sort="Barkardottir, Rosa B" uniqKey="Barkardottir R" first="Rosa B" last="Barkardottir">Rosa B. Barkardottir</name><affiliation wicri:level="1"><nlm:aff id="A152">Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Laframboise, Rachel" sort="Laframboise, Rachel" uniqKey="Laframboise R" first="Rachel" last="Laframboise">Rachel Laframboise</name><affiliation wicri:level="1"><nlm:aff id="A153">Medical Genetic Division, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Medical Genetic Division, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation wicri:level="1"><nlm:aff id="A154">Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation wicri:level="1"><nlm:aff id="A155">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua</wicri:regionArea></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation wicri:level="1"><nlm:aff id="A155">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua</wicri:regionArea></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name><affiliation wicri:level="1"><nlm:aff id="A156">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Genetics, Portuguese Oncology Institute, Porto</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A157">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Biomedical Sciences Institute (ICBAS), Porto University, Porto</wicri:regionArea></affiliation></author><author><name sortKey="Park, Sue Kyung" sort="Park, Sue Kyung" uniqKey="Park S" first="Sue Kyung" last="Park">Sue Kyung Park</name><affiliation wicri:level="1"><nlm:aff id="A86">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A87">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A158">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation wicri:level="1"><nlm:aff id="A159">Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Cancer Genetics, McGill University, Montreal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation wicri:level="1"><nlm:aff id="A160">Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno</wicri:regionArea></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation wicri:level="1"><nlm:aff id="A161">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation wicri:level="1"><nlm:aff id="A161">Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name><affiliation wicri:level="1"><nlm:aff id="A162">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation wicri:level="1"><nlm:aff id="A162">Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name><affiliation wicri:level="1"><nlm:aff id="A163">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida</wicri:regionArea></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name><affiliation wicri:level="1"><nlm:aff id="A164">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name><affiliation wicri:level="1"><nlm:aff id="A164">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation wicri:level="1"><nlm:aff id="A165">Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A166">Clalit National Israeli Cancer Control Center, Haifa, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Clalit National Israeli Cancer Control Center, Haifa</wicri:regionArea></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N" last="Imyanitov">Evgeny N. Imyanitov</name><affiliation wicri:level="1"><nlm:aff id="A167">N.N. Petrov Institute of Oncology, St. Petersburg, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>N.N. Petrov Institute of Oncology, St. Petersburg</wicri:regionArea></affiliation></author><author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J" last="Hulick">Peter J. Hulick</name><affiliation wicri:level="1"><nlm:aff id="A168">Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation wicri:level="1"><nlm:aff id="A169">Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation wicri:level="1"><nlm:aff id="A170">NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York</wicri:regionArea></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation wicri:level="1"><nlm:aff id="A171">Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine Program, University Health Network, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A172">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation wicri:level="1"><nlm:aff id="A72">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name><affiliation wicri:level="1"><nlm:aff id="A173">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Genetics, Vejle Hospital, Vejle</wicri:regionArea></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation wicri:level="1"><nlm:aff id="A174">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Genetics, Odense University Hospital, Odense</wicri:regionArea></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name><affiliation wicri:level="1"><nlm:aff id="A175">Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa</wicri:regionArea></affiliation></author><author><name sortKey="Yoon, Sook Yee" sort="Yoon, Sook Yee" uniqKey="Yoon S" first="Sook-Yee" last="Yoon">Sook-Yee Yoon</name><affiliation wicri:level="1"><nlm:aff id="A64">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A176">University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation wicri:level="1"><nlm:aff id="A177">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation wicri:level="1"><nlm:aff id="A177">Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name><affiliation wicri:level="1"><nlm:aff id="A178">Department of Oncology, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Von Wachenfeldt, Anna" sort="Von Wachenfeldt, Anna" uniqKey="Von Wachenfeldt A" first="Anna" last="Von Wachenfeldt">Anna Von Wachenfeldt</name><affiliation wicri:level="1"><nlm:aff id="A49">Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology-Pathology, Karolinska University Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation wicri:level="1"><nlm:aff id="A179">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A180">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Genetics, Lund University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation wicri:level="1"><nlm:aff id="A181">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Genetics, Karolinska University Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I" last="Olopade">Olufunmilayo I. Olopade</name><affiliation wicri:level="1"><nlm:aff id="A182">Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A" last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="1"><nlm:aff id="A183">Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine and School of Public Health, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine and School of Public Health, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L" last="Nussbaum">Robert L. Nussbaum</name><affiliation wicri:level="1"><nlm:aff id="A184">Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation wicri:level="1"><nlm:aff id="A32">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="1"><nlm:aff id="A185">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name><affiliation wicri:level="1"><nlm:aff id="A185">Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K" last="Arun">Banu K. Arun</name><affiliation wicri:level="1"><nlm:aff id="A186">University of Texas MD Anderson Cancer Center, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Gillian" sort="Mitchell, Gillian" uniqKey="Mitchell G" first="Gillian" last="Mitchell">Gillian Mitchell</name><affiliation wicri:level="1"><nlm:aff id="A187">Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A188">Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><affiliation wicri:level="1"><nlm:aff id="A189">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation wicri:level="1"><nlm:aff id="A189">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name><affiliation wicri:level="1"><nlm:aff id="A190">University of Hawaii Cancer Center, Honolulu, Hawaii, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea></affiliation></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name><affiliation wicri:level="1"><nlm:aff id="A191">Department of Obstetrics, Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Obstetrics, Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Christopher" sort="Scott, Christopher" uniqKey="Scott C" first="Christopher" last="Scott">Christopher Scott</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation wicri:level="1"><nlm:aff id="A192">Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia</wicri:regionArea></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation wicri:level="1"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation wicri:level="1"><nlm:aff id="A193">Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A194">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A195">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation wicri:level="1"><nlm:aff id="A196">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A196">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Haakensen, Vilde" sort="Haakensen, Vilde" uniqKey="Haakensen V" first="Vilde" last="Haakensen">Vilde Haakensen</name><affiliation wicri:level="1"><nlm:aff id="A66">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Dowsett, Mitch" sort="Dowsett, Mitch" uniqKey="Dowsett M" first="Mitch" last="Dowsett">Mitch Dowsett</name><affiliation wicri:level="1"><nlm:aff id="A4">Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Academic Biochemistry, Royal Marsden Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Biochemistry, Royal Marsden Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D P" last="Pharoah">Paul D P. Pharoah</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="A154">Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation wicri:level="1"><nlm:aff id="A101">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A102">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="A1">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L" last="Edwards">Stacey L. Edwards</name><affiliation wicri:level="1"><nlm:aff id="A3">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We analyzed 3,872 common genetic variants across the
<italic>ESR1</italic> locus (encoding estrogen receptor α) in
118,816 subjects from three international consortia. We found evidence for at
least five independent causal variants, each associated with different phenotype
sets, including estrogen receptor (ER<sup>+</sup> or
ER<sup>−</sup>) and human ERBB2 (HER2<sup>+</sup> or
HER2<sup>−</sup>) tumor subtypes, mammographic density and tumor
grade. The best candidate causal variants for ER<sup>−</sup> tumors lie
in four separate enhancer elements, and their risk alleles reduce expression of
<italic>ESR1</italic>, <italic>RMND1</italic> and <italic>CCDC170</italic>,
whereas the risk alleles of the strongest candidates for the remaining
independent causal variant disrupt a silencer element and putatively increase
<italic>ESR1</italic> and <italic>RMND1</italic> expression.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26928228</article-id><article-id pub-id-type="pmc">4938803</article-id><article-id pub-id-type="doi">10.1038/ng.3521</article-id><article-id pub-id-type="manuscript">NIHMS783876</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Breast cancer risk variants at 6q25 display different phenotype
associations and regulate <italic>ESR1</italic>, <italic>RMND1</italic> and
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contrib-type="author"><name><surname>Woolcott</surname><given-names>Christy</given-names></name><xref ref-type="aff" rid="A191">192</xref></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Stone</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A192">193</xref></contrib><contrib contrib-type="author"><name><surname>Apicella</surname><given-names>Carmel</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Tamimi</surname><given-names>Rulla</given-names></name><xref ref-type="aff" rid="A193">194</xref><xref ref-type="aff" rid="A194">195</xref><xref ref-type="aff" rid="A195">196</xref></contrib><contrib contrib-type="author"><name><surname>Luben</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A196">197</xref></contrib><contrib contrib-type="author"><name><surname>Khaw</surname><given-names>Kay-Tee</given-names></name><xref ref-type="aff" rid="A196">197</xref></contrib><contrib contrib-type="author"><name><surname>Helland</surname><given-names>Åslaug</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Haakensen</surname><given-names>Vilde</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Dowsett</surname><given-names>Mitch</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D P</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A154">155</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A80">80</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="A101">101</xref><xref ref-type="aff" rid="A102">102</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref rid="FN4" ref-type="author-notes">199</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN4" ref-type="author-notes">199</xref></contrib><contrib contrib-type="author"><name><surname>Edwards</surname><given-names>Stacey L</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref rid="FN4" ref-type="author-notes">199</xref></contrib></contrib-group><aff id="A1"><label>1</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A2"><label>2</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A3"><label>3</label>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</aff><aff id="A4"><label>4</label>Breast Cancer Research, Breakthrough Breast Cancer Research Centre, London, UK</aff><aff id="A5"><label>5</label>Academic Biochemistry, Royal Marsden Hospital, London, UK</aff><aff id="A6"><label>6</label>Department of Genetics, Stanford University School of Medicine, Stanford, California, USA</aff><aff id="A7"><label>7</label>Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA</aff><aff id="A8"><label>8</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</aff><aff id="A9"><label>9</label>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A10"><label>10</label>Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A11"><label>11</label>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</aff><aff id="A12"><label>12</label>Institute of Population Health, University of Manchester, Manchester, UK</aff><aff id="A13"><label>13</label>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany</aff><aff id="A14"><label>14</label>Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA</aff><aff id="A15"><label>15</label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="A16"><label>16</label>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK</aff><aff id="A17"><label>17</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A18"><label>18</label>Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</aff><aff id="A19"><label>19</label>Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A20"><label>20</label>Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A21"><label>21</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="A22"><label>22</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="A23"><label>23</label>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</aff><aff id="A24"><label>24</label>University Paris–Sud, Villejuif, France</aff><aff id="A25"><label>25</label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A26"><label>26</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A27"><label>27</label>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A28"><label>28</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A29"><label>29</label>Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain</aff><aff id="A30"><label>30</label>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</aff><aff id="A31"><label>31</label>Department of Epidemiology, University of California–Irvine, Irvine, California, USA</aff><aff id="A32"><label>32</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA</aff><aff id="A33"><label>33</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A34"><label>34</label>German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A35"><label>35</label>Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany</aff><aff id="A36"><label>36</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</aff><aff id="A37"><label>37</label>Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</aff><aff id="A38"><label>38</label>Center for Integrated Oncology, University Hospital, Cologne, Germany</aff><aff id="A39"><label>39</label>Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="A40"><label>40</label>University of Tübingen, Tübingen, Germany</aff><aff id="A41"><label>41</label>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A42"><label>42</label>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A43"><label>43</label>Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="A44"><label>44</label>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</aff><aff id="A45"><label>45</label>Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan</aff><aff id="A46"><label>46</label>Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="A47"><label>47</label>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="A48"><label>48</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A49"><label>49</label>Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A50"><label>50</label>Cancer Center, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A51"><label>51</label>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="A52"><label>52</label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A53"><label>53</label>Vesalius Research Center, Leuven, Belgium</aff><aff id="A54"><label>54</label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</aff><aff id="A55"><label>55</label>Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium</aff><aff id="A56"><label>56</label>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A57"><label>57</label>University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A58"><label>58</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A59"><label>59</label>Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</aff><aff id="A60"><label>60</label>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A61"><label>61</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</aff><aff id="A62"><label>62</label>Department of Medicine, McGill University, Montreal, Quebec, Canada</aff><aff id="A63"><label>63</label>Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada</aff><aff id="A64"><label>64</label>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</aff><aff id="A65"><label>65</label>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</aff><aff id="A66"><label>66</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</aff><aff id="A67"><label>67</label>Institute of Clinical Medicine, University of Oslo, Oslo, Norway</aff><aff id="A68"><label>68</label>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</aff><aff id="A69"><label>69</label>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA</aff><aff id="A70"><label>70</label>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu University Hospital, Oulu, Finland</aff><aff id="A71"><label>71</label>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</aff><aff id="A72"><label>72</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</aff><aff id="A73"><label>73</label>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A74"><label>74</label>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada</aff><aff id="A75"><label>75</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A76"><label>76</label>Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands</aff><aff id="A77"><label>77</label>Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands</aff><aff id="A78"><label>78</label>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands</aff><aff id="A79"><label>79</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA</aff><aff id="A80"><label>80</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A81"><label>81</label>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands</aff><aff id="A82"><label>82</label>Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</aff><aff id="A83"><label>83</label>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A84"><label>84</label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</aff><aff id="A85"><label>85</label>International Epidemiology Institute, Rockville, Maryland, USA</aff><aff id="A86"><label>86</label>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A87"><label>87</label>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A88"><label>88</label>Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A89"><label>89</label>Department of Haematology-Oncology, National University Health System, Singapore</aff><aff id="A90"><label>90</label>Cancer Science Institute of Singapore, National University of Singapore, Singapore</aff><aff id="A91"><label>91</label>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</aff><aff id="A92"><label>92</label>Department of Surgery, National University Health System, Singapore</aff><aff id="A93"><label>93</label>Institute of Human Genetics, Pontificia Universidad Javerianar, Bogota, Colombia</aff><aff id="A94"><label>94</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A95"><label>95</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="A96"><label>96</label>National Cancer Institute, Bangkok, Thailand</aff><aff id="A97"><label>97</label>Roswell Park Cancer Institute, Buffalo, New York, USA</aff><aff id="A98"><label>98</label>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA</aff><aff id="A99"><label>99</label>School of Public Health, China Medical University, Taichung, Taiwan</aff><aff id="A100"><label>100</label>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</aff><aff id="A101"><label>101</label>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</aff><aff id="A102"><label>102</label>Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</aff><aff id="A103"><label>103</label>Division of Breast Cancer Research, Institute of Cancer Research, London, UK</aff><aff id="A104"><label>104</label>Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A105"><label>105</label>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA</aff><aff id="A106"><label>106</label>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</aff><aff id="A107"><label>107</label>Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</aff><aff id="A108"><label>108</label>Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff><aff id="A109"><label>109</label>Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff><aff id="A110"><label>110</label>State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania</aff><aff id="A111"><label>111</label>Latvian Biomedical Research and Study Centre, Riga, Latvia</aff><aff id="A112"><label>112</label>Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA</aff><aff id="A113"><label>113</label>Department of Genetics, University of Pretoria, Pretoria, South Africa</aff><aff id="A114"><label>114</label>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA</aff><aff id="A115"><label>115</label>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A116"><label>116</label>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A117"><label>117</label>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</aff><aff id="A118"><label>118</label>Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</aff><aff id="A119"><label>119</label>Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A120"><label>120</label>City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA</aff><aff id="A121"><label>121</label>Clinical Cancer Genetics, City of Hope, Duarte, California, USA</aff><aff id="A122"><label>122</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</aff><aff id="A123"><label>123</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy</aff><aff id="A124"><label>124</label>Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</aff><aff id="A125"><label>125</label>Department of Molecular Medicine, University La Sapienza, Rome, Italy</aff><aff id="A126"><label>126</label>Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis, Athens, Greece</aff><aff id="A127"><label>127</label>Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A128"><label>128</label>Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan</aff><aff id="A129"><label>130</label>Clinical Genetics, Guy’s and St. Thomas’ National Health Service (NHS) Foundation Trust, London, UK</aff><aff id="A130"><label>131</label>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA</aff><aff id="A131"><label>132</label>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany</aff><aff id="A132"><label>133</label>University Düsseldorf, Dusseldorf, Germany</aff><aff id="A133"><label>134</label>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, Cologne, Germany</aff><aff id="A134"><label>135</label>Institute of Human Genetics, Münster, Germany</aff><aff id="A135"><label>136</label>INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France</aff><aff id="A136"><label>137</label>Institut Curie, Department of Tumour Biology, Paris, France</aff><aff id="A137"><label>138</label>Université Paris Descartes, Sorbonne Paris Cité, Paris, France</aff><aff id="A138"><label>139</label>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon–Centre Léon Bérard, Lyon, France</aff><aff id="A139"><label>140</label>Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA</aff><aff id="A140"><label>141</label>Center for Medical Genetics, Ghent University, Ghent, Belgium</aff><aff id="A141"><label>142</label>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain</aff><aff id="A142"><label>143</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A143"><label>144</label>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</aff><aff id="A144"><label>145</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands</aff><aff id="A145"><label>146</label>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands</aff><aff id="A146"><label>147</label>Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</aff><aff id="A147"><label>148</label>Department of Surgery, University of Hong Kong, Hong Kong</aff><aff id="A148"><label>149</label>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</aff><aff id="A149"><label>150</label>Oncogenetics Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, Barcelona, Spain</aff><aff id="A150"><label>151</label>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain</aff><aff id="A151"><label>152</label>Breast Cancer and Systems Biology Unit, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A152"><label>153</label>Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A153"><label>154</label>Medical Genetic Division, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</aff><aff id="A154"><label>155</label>Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada</aff><aff id="A155"><label>156</label>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Padua, Italy</aff><aff id="A156"><label>157</label>Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</aff><aff id="A157"><label>158</label>Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</aff><aff id="A158"><label>159</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A159"><label>160</label>Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada</aff><aff id="A160"><label>161</label>Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno, Czech Republic</aff><aff id="A161"><label>162</label>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA</aff><aff id="A162"><label>163</label>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</aff><aff id="A163"><label>164</label>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</aff><aff id="A164"><label>165</label>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA</aff><aff id="A165"><label>166</label>Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel</aff><aff id="A166"><label>167</label>Clalit National Israeli Cancer Control Center, Haifa, Israel</aff><aff id="A167"><label>168</label>N.N. Petrov Institute of Oncology, St. Petersburg, Russia</aff><aff id="A168"><label>169</label>Center for Medical Genetics, NorthShore University Health System, Evanston, Illinois, USA</aff><aff id="A169"><label>170</label>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia</aff><aff id="A170"><label>171</label>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA</aff><aff id="A171"><label>172</label>Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</aff><aff id="A172"><label>173</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A173"><label>174</label>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</aff><aff id="A174"><label>175</label>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</aff><aff id="A175"><label>176</label>Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy</aff><aff id="A176"><label>177</label>University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</aff><aff id="A177"><label>178</label>Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</aff><aff id="A178"><label>179</label>Department of Oncology, Lund University, Lund, Sweden</aff><aff id="A179"><label>180</label>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</aff><aff id="A180"><label>181</label>Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</aff><aff id="A181"><label>182</label>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A182"><label>183</label>Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA</aff><aff id="A183"><label>184</label>Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine and School of Public Health, Los Angeles, California, USA</aff><aff id="A184"><label>185</label>Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA</aff><aff id="A185"><label>186</label>Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</aff><aff id="A186"><label>187</label>University of Texas MD Anderson Cancer Center, Houston, Texas, USA</aff><aff id="A187"><label>188</label>Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</aff><aff id="A188"><label>189</label>Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A189"><label>190</label>Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff><aff id="A190"><label>191</label>University of Hawaii Cancer Center, Honolulu, Hawaii, USA</aff><aff id="A191"><label>192</label>Department of Obstetrics, Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada</aff><aff id="A192"><label>193</label>Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Western Australia, Australia</aff><aff id="A193"><label>194</label>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A194"><label>195</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A195"><label>196</label>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A196"><label>197</label>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><author-notes><corresp id="FN1">Correspondence should be addressed to A.M.D.
(<email>amd24@medschl.cam.ac.uk</email>), D.F.E.
(<email>dfe20@medschl.cam.ac.uk</email>) or S.L.E.
(<email>stacey.edwards@qimrberghofer.edu.au</email>)</corresp><fn id="FN2"><label>129</label><p>A full list of members appears in the <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>.</p></fn><fn id="FN3" fn-type="equal"><label>198</label><p>These authors contributed equally to this work.</p></fn><fn id="FN4"><label>199</label><p>These authors jointly supervised this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>29</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2016</year></pub-date><volume>48</volume><issue>4</issue><fpage>374</fpage><lpage>386</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.3521</pmc-comment>
<permissions><license license-type="permissions-link"><license-p>Reprints and permissions information is available online at <ext-link ext-link-type="uri" xlink:href="http://www.nature.com/reprints/index.html">http://www.nature.com/reprints/index.html</ext-link>.</license-p></license></permissions><abstract><p id="P1">We analyzed 3,872 common genetic variants across the
<italic>ESR1</italic> locus (encoding estrogen receptor α) in
118,816 subjects from three international consortia. We found evidence for at
least five independent causal variants, each associated with different phenotype
sets, including estrogen receptor (ER<sup>+</sup> or
ER<sup>−</sup>) and human ERBB2 (HER2<sup>+</sup> or
HER2<sup>−</sup>) tumor subtypes, mammographic density and tumor
grade. The best candidate causal variants for ER<sup>−</sup> tumors lie
in four separate enhancer elements, and their risk alleles reduce expression of
<italic>ESR1</italic>, <italic>RMND1</italic> and <italic>CCDC170</italic>,
whereas the risk alleles of the strongest candidates for the remaining
independent causal variant disrupt a silencer element and putatively increase
<italic>ESR1</italic> and <italic>RMND1</italic> expression.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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