Genome-wide association analysis identifies six new loci associated with forced vital capacity
Identifieur interne : 001F98 ( Pmc/Curation ); précédent : 001F97; suivant : 001F99Genome-wide association analysis identifies six new loci associated with forced vital capacity
Auteurs : Daan W. Loth [Pays-Bas] ; María Soler Artigas [Royaume-Uni] ; Sina A. Gharib [États-Unis] ; Louise V. Wain [Royaume-Uni] ; Nora Franceschini [États-Unis] ; Beate Koch [Allemagne] ; Tess Pottinger [États-Unis] ; Albert Vernon Smith [Islande] ; Qing Duan [États-Unis] ; Chris Oldmeadow [Australie] ; Mi Kyeong Lee [Corée du Sud] ; David P. Strachan [Royaume-Uni] ; Alan L. James [Australie] ; Jennifer E. Huffman [Royaume-Uni] ; Veronique Vitart [Royaume-Uni] ; Adaikalavan Ramasamy [Royaume-Uni] ; Nicholas J. Wareham [Royaume-Uni] ; Jaakko Kaprio [Finlande] ; Xin-Qun Wang [États-Unis] ; Holly Trochet [Royaume-Uni] ; Mika K Hönen [Finlande] ; Claudia Flexeder [Allemagne] ; Eva Albrecht [Allemagne] ; Lorna M. Lopez [Royaume-Uni] ; Kim De Jong [Pays-Bas] ; Bharat Thyagarajan [États-Unis] ; Alexessander Couto Alves [Royaume-Uni] ; Stefan Enroth [Suède] ; Ernst Omenaas [Norvège] ; Peter K. Joshi [Royaume-Uni] ; Tove Fall [Suède] ; Ana Vi Uela [Royaume-Uni] ; Lenore J. Launer [États-Unis] ; Laura R. Loehr [États-Unis] ; Myriam Fornage [États-Unis] ; Guo Li [États-Unis] ; Jemma B. Wilk [États-Unis] ; Wenbo Tang [États-Unis] ; Ani Manichaikul [États-Unis] ; Lies Lahousse [Pays-Bas, Belgique] ; Tamara B. Harris [États-Unis] ; Kari E. North [États-Unis] ; Alicja R. Rudnicka [Royaume-Uni] ; Jennie Hui [Australie] ; Xiangjun Gu [États-Unis] ; Thomas Lumley [Nouvelle-Zélande] ; Alan F. Wright [Royaume-Uni] ; Nicholas D. Hastie [Royaume-Uni] ; Susan Campbell [Royaume-Uni] ; Rajesh Kumar [États-Unis] ; Isabelle Pin [France] ; Robert A. Scott [Royaume-Uni] ; Kirsi H. Pietil Inen [Finlande] ; Ida Surakka [Finlande] ; Yongmei Liu [États-Unis] ; Elizabeth G. Holliday [Australie] ; Holger Schulz [Allemagne] ; Joachim Heinrich [Allemagne] ; Gail Davies [Royaume-Uni] ; Judith M. Vonk [Pays-Bas] ; Mary Wojczynski [États-Unis] ; Anneli Pouta [Finlande] ; Sa Johansson [Suède] ; Sarah H. Wild [Royaume-Uni] ; Erik Ingelsson [Suède, Royaume-Uni] ; Fernando Rivadeneira [Pays-Bas] ; Henry Völzke [Allemagne] ; Pirro G. Hysi [Royaume-Uni] ; Gudny Eiriksdottir [Islande] ; Alanna C. Morrison [États-Unis] ; Jerome I. Rotter [États-Unis] ; Wei Gao [États-Unis] ; Dirkje S. Postma [Pays-Bas] ; Wendy B. White [États-Unis] ; Stephen S. Rich [États-Unis] ; Albert Hofman [Pays-Bas] ; Thor Aspelund [Islande] ; David Couper [États-Unis] ; Lewis J. Smith [États-Unis] ; Bruce M. Psaty [États-Unis] ; Kurt Lohman [États-Unis] ; Esteban G. Burchard [États-Unis] ; André G. Uitterlinden [Pays-Bas] ; Melissa Garcia [États-Unis] ; Bonnie R. Joubert [États-Unis] ; Wendy L. Mcardle [Royaume-Uni] ; A. Bill Musk [Australie] ; Nadia Hansel [États-Unis] ; Susan R. Heckbert [États-Unis] ; Lina Zgaga [Irlande (pays), Croatie] ; Joyce B. J. Van Meurs [Pays-Bas] ; Pau Navarro [Royaume-Uni] ; Igor Rudan [Royaume-Uni] ; Yeon-Mok Oh [Corée du Sud] ; Susan Redline [États-Unis] ; Deborah Jarvis [Royaume-Uni] ; Jing Hua Zhao [Royaume-Uni] ; Taina Rantanen [Finlande] ; George T. O Onnor [États-Unis] ; Samuli Ripatti [Finlande, Royaume-Uni] ; Rodney J. Scott [Australie] ; Stefan Karrasch [Allemagne] ; Harald Grallert [Allemagne] ; Nathan C. Gaddis [États-Unis] ; John M. Starr [Royaume-Uni] ; Cisca Wijmenga [Pays-Bas] ; Ryan L. Minster [États-Unis] ; David J. Lederer [États-Unis] ; Juha Pekkanen [Finlande] ; Ulf Gyllensten [Suède] ; Harry Campbell [Royaume-Uni] ; Andrew P. Morris [Royaume-Uni] ; Sven Gl Ser [Allemagne] ; Christopher J. Hammond [Royaume-Uni] ; Kristin M. Burkart [États-Unis] ; John Beilby [Australie] ; Stephen B. Kritchevsky [États-Unis] ; Vilmundur Gudnason [Islande] ; Dana B. Hancock [États-Unis] ; O. Dale Williams [États-Unis] ; Ozren Polasek [Croatie] ; Tatijana Zemunik [Croatie] ; Ivana Kolcic [Croatie] ; Marcy F. Petrini [États-Unis] ; Matthias Wjst [Allemagne] ; Woo Jin Kim [Corée du Sud] ; David J. Porteous [Royaume-Uni] ; Generation Scotland [États-Unis] ; Blair H. Smith [États-Unis] ; Anne Viljanen [Finlande] ; Markku Heliövaara [Finlande] ; John R. Attia [Australie] ; Ian Sayers [Royaume-Uni] ; Regina Hampel [Allemagne] ; Christian Gieger [Allemagne] ; Ian J. Deary [Royaume-Uni] ; H. Marike Boezen [Pays-Bas] ; Anne Newman [États-Unis] ; Marjo-Riitta Jarvelin [Royaume-Uni, Finlande] ; James F. Wilson [Royaume-Uni] ; Lars Lind [Suède] ; Bruno H. Stricker [Pays-Bas] ; Alexander Teumer [Allemagne] ; Timothy D. Spector [Royaume-Uni] ; Erik Melén [Suède] ; Marjolein J. Peters [Pays-Bas] ; Leslie A. Lange [États-Unis] ; R. Graham Barr [États-Unis] ; Ken R. Bracke [Belgique] ; Fien M. Verhamme [Belgique] ; Joohon Sung [Corée du Sud] ; Pieter S. Hiemstra [Pays-Bas] ; Patricia A. Cassano [États-Unis] ; Akshay Sood [États-Unis] ; Caroline Hayward [Royaume-Uni] ; Josée Dupuis [États-Unis] ; Ian P. Hall [Royaume-Uni] ; Guy G. Brusselle [Pays-Bas, Belgique] ; Martin D. Tobin [Royaume-Uni] ; Stephanie J. London [États-Unis]Source :
- Nature genetics [ 1061-4036 ] ; 2014.
Abstract
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (
Url:
DOI: 10.1038/ng.3011
PubMed: 24929828
PubMed Central: 4140093
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Loth</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Health Care Inspectorate, The Hague, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Health Care Inspectorate, The Hague</wicri:regionArea></affiliation></author><author><name sortKey="Artigas, Maria Soler" sort="Artigas, Maria Soler" uniqKey="Artigas M" first="María Soler" last="Artigas">María Soler Artigas</name><affiliation wicri:level="1"><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea></affiliation></author><author><name sortKey="Gharib, Sina A" sort="Gharib, Sina A" uniqKey="Gharib S" first="Sina A." last="Gharib">Sina A. 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Huffman</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation wicri:level="1"><nlm:aff id="A22">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="1"><nlm:aff id="A25">Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>The National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xin Qun" sort="Wang, Xin Qun" uniqKey="Wang X" first="Xin-Qun" last="Wang">Xin-Qun Wang</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Public Health Sciences, University of Virginia, Charlottesville, VA</wicri:regionArea></affiliation></author><author><name sortKey="Trochet, Holly" sort="Trochet, Holly" uniqKey="Trochet H" first="Holly" last="Trochet">Holly Trochet</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere</wicri:regionArea></affiliation></author><author><name sortKey="Flexeder, Claudia" sort="Flexeder, Claudia" uniqKey="Flexeder C" first="Claudia" last="Flexeder">Claudia Flexeder</name><affiliation wicri:level="1"><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="1"><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="De Jong, Kim" sort="De Jong, Kim" uniqKey="De Jong K" first="Kim" last="De Jong">Kim De Jong</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Thyagarajan, Bharat" sort="Thyagarajan, Bharat" uniqKey="Thyagarajan B" first="Bharat" last="Thyagarajan">Bharat Thyagarajan</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Alves, Alexessander Couto" sort="Alves, Alexessander Couto" uniqKey="Alves A" first="Alexessander Couto" last="Alves">Alexessander Couto Alves</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Omenaas, Ernst" sort="Omenaas, Ernst" uniqKey="Omenaas E" first="Ernst" last="Omenaas">Ernst Omenaas</name><affiliation wicri:level="1"><nlm:aff id="A39">Haukeland University Hospital, Bergen, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Haukeland University Hospital, Bergen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">Department Clinical Sciences, University of Bergen, Bergen, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department Clinical Sciences, University of Bergen, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Vi Uela, Ana" sort="Vi Uela, Ana" uniqKey="Vi Uela A" first="Ana" last="Vi Uela">Ana Vi Uela</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Twins Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Loehr, Laura R" sort="Loehr, Laura R" uniqKey="Loehr L" first="Laura R." last="Loehr">Laura R. Loehr</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A46">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation wicri:level="1"><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name><affiliation wicri:level="1"><nlm:aff id="A48">Precision Medicine, Pfizer Global Research and Development, Cambridge, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Precision Medicine, Pfizer Global Research and Development, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Tang, Wenbo" sort="Tang, Wenbo" uniqKey="Tang W" first="Wenbo" last="Tang">Wenbo Tang</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Nutritional Sciences, Cornell University, Ithaca, NY</wicri:regionArea></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation wicri:level="1"><nlm:aff id="A50">Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia</wicri:regionArea></affiliation></author><author><name sortKey="Lahousse, Lies" sort="Lahousse, Lies" uniqKey="Lahousse L" first="Lies" last="Lahousse">Lies Lahousse</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Department of Respiratory Medicine, Ghent University Hospital, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name><affiliation wicri:level="1"><nlm:aff id="A17">Division of Population Health Sciences and Education, St George's, University of London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Division of Population Health Sciences and Education, St George's, University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation wicri:level="1"><nlm:aff id="A53">PathWest Laboratory Medicine WA, Nedlands, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>PathWest Laboratory Medicine WA, Nedlands</wicri:regionArea></affiliation></author><author><name sortKey="Gu, Xiangjun" sort="Gu, Xiangjun" uniqKey="Gu X" first="Xiangjun" last="Gu">Xiangjun Gu</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A46">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name><affiliation wicri:level="1"><nlm:aff id="A54">Department of Statistics, University of Auckland, Auckland, New Zealand.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Nouvelle-Zélande</country><wicri:regionArea>Department of Statistics, University of Auckland, Auckland</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Hastie, Nicholas D" sort="Hastie, Nicholas D" uniqKey="Hastie N" first="Nicholas D." last="Hastie">Nicholas D. Hastie</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Susan" sort="Campbell, Susan" uniqKey="Campbell S" first="Susan" last="Campbell">Susan Campbell</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Kumar, Rajesh" sort="Kumar, Rajesh" uniqKey="Kumar R" first="Rajesh" last="Kumar">Rajesh Kumar</name><affiliation wicri:level="1"><nlm:aff id="A55">Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name><affiliation wicri:level="1"><nlm:aff id="A56">Centre Hospitallier Universitaire de Grenoble, Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Centre Hospitallier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">INSERM U823, Institut Albert Bonniot, Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>INSERM U823, Institut Albert Bonniot, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Université Joseph Fourier, Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A." last="Scott">Robert A. Scott</name><affiliation wicri:level="1"><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H." last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A59">Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="1"><nlm:aff id="A62">Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Faculty of Health, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Schulz, Holger" sort="Schulz, Holger" uniqKey="Schulz H" first="Holger" last="Schulz">Holger Schulz</name><affiliation wicri:level="1"><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation wicri:level="1"><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation wicri:level="1"><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A63">Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A64">MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Institute of Genetics and Molecular Medicine, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Vonk, Judith M" sort="Vonk, Judith M" uniqKey="Vonk J" first="Judith M." last="Vonk">Judith M. Vonk</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Wojczynski, Mary" sort="Wojczynski, Mary" uniqKey="Wojczynski M" first="Mary" last="Wojczynski">Mary Wojczynski</name><affiliation wicri:level="1"><nlm:aff id="A65">Department of Statistical Genomics, Washington University, St. Louis, MO, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Statistical Genomics, Washington University, St. Louis, MO</wicri:regionArea></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="A66">National Institute for Health and Welfare, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A68">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Uppsala Clinical Research Center, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A70">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="A73">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Twins Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>Iceland Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><affiliation wicri:level="1"><nlm:aff id="A74">School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>School of Public Health, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="1"><nlm:aff id="A75">Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A76">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Wei" sort="Gao, Wei" uniqKey="Gao W" first="Wei" last="Gao">Wei Gao</name><affiliation wicri:level="1"><nlm:aff id="A77">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name><affiliation wicri:level="1"><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A78">University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="White, Wendy B" sort="White, Wendy B" uniqKey="White W" first="Wendy B." last="White">Wendy B. White</name><affiliation wicri:level="1"><nlm:aff id="A79">Tougaloo College, Jackson, MS, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Tougaloo College, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name><affiliation wicri:level="1"><nlm:aff id="A50">Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>Iceland Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Couper, David" sort="Couper, David" uniqKey="Couper D" first="David" last="Couper">David Couper</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Lewis J" sort="Smith, Lewis J" uniqKey="Smith L" first="Lewis J." last="Smith">Lewis J. Smith</name><affiliation wicri:level="1"><nlm:aff id="A55">Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A81">Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A82">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation wicri:level="1"><nlm:aff id="A83">Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Burchard, Esteban G" sort="Burchard, Esteban G" uniqKey="Burchard E" first="Esteban G." last="Burchard">Esteban G. Burchard</name><affiliation wicri:level="1"><nlm:aff id="A84">Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A85">Department of Medicine, University of California, San Francisco, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, University of California, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation wicri:level="1"><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Joubert, Bonnie R" sort="Joubert, Bonnie R" uniqKey="Joubert B" first="Bonnie R." last="Joubert">Bonnie R. Joubert</name><affiliation wicri:level="1"><nlm:aff id="A86">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC</wicri:regionArea></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation wicri:level="1"><nlm:aff id="A87">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Musk, A Bill" sort="Musk, A Bill" uniqKey="Musk A" first="A. Bill" last="Musk">A. Bill Musk</name><affiliation wicri:level="1"><nlm:aff id="A88">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands</wicri:regionArea></affiliation></author><author><name sortKey="Hansel, Nadia" sort="Hansel, Nadia" uniqKey="Hansel N" first="Nadia" last="Hansel">Nadia Hansel</name><affiliation wicri:level="1"><nlm:aff id="A89">Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, Johns Hopkins University, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Heckbert, Susan R" sort="Heckbert, Susan R" uniqKey="Heckbert S" first="Susan R." last="Heckbert">Susan R. Heckbert</name><affiliation wicri:level="1"><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A81">Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A82">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation wicri:level="1"><nlm:aff id="A90">Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Irlande (pays)</country><wicri:regionArea>Department of Public Health and Primary Care, Trinity College Dublin, Dublin</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Croatie</country><wicri:regionArea>Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B. J." last="Van Meurs">Joyce B. J. Van Meurs</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="1"><nlm:aff id="A92">Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Oh, Yeon Mok" sort="Oh, Yeon Mok" uniqKey="Oh Y" first="Yeon-Mok" last="Oh">Yeon-Mok Oh</name><affiliation wicri:level="1"><nlm:aff id="A93">Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A94">Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="1"><nlm:aff id="A95">Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham Women's Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Jarvis, Deborah" sort="Jarvis, Deborah" uniqKey="Jarvis D" first="Deborah" last="Jarvis">Deborah Jarvis</name><affiliation wicri:level="1"><nlm:aff id="A22">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A96">MRC-PHE Centre for Environment & Health, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC-PHE Centre for Environment & Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="1"><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Rantanen, Taina" sort="Rantanen, Taina" uniqKey="Rantanen T" first="Taina" last="Rantanen">Taina Rantanen</name><affiliation wicri:level="1"><nlm:aff id="A97">Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä</wicri:regionArea></affiliation></author><author><name sortKey="O Onnor, George T" sort="O Onnor, George T" uniqKey="O Onnor G" first="George T." last="O Onnor">George T. O Onnor</name><affiliation wicri:level="1"><nlm:aff id="A98">Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Pulmonary Center, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A99">The NHLBI's Framingham Heart Study, Framingham, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>The NHLBI's Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A100">Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Faculty of Health, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Karrasch, Stefan" sort="Karrasch, Stefan" uniqKey="Karrasch S" first="Stefan" last="Karrasch">Stefan Karrasch</name><affiliation wicri:level="1"><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A101">Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A102">Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation wicri:level="1"><nlm:aff id="A103">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Gaddis, Nathan C" sort="Gaddis, Nathan C" uniqKey="Gaddis N" first="Nathan C." last="Gaddis">Nathan C. Gaddis</name><affiliation wicri:level="1"><nlm:aff id="A104">Research Computing Division, Research Triangle Institute International, Research Triangle Park, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Research Computing Division, Research Triangle Institute International, Research Triangle Park, NC</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A105">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation wicri:level="1"><nlm:aff id="A106">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Minster, Ryan L" sort="Minster, Ryan L" uniqKey="Minster R" first="Ryan L." last="Minster">Ryan L. Minster</name><affiliation wicri:level="1"><nlm:aff id="A107">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Lederer, David J" sort="Lederer, David J" uniqKey="Lederer D" first="David J." last="Lederer">David J. Lederer</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A108">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Pekkanen, Juha" sort="Pekkanen, Juha" uniqKey="Pekkanen J" first="Juha" last="Pekkanen">Juha Pekkanen</name><affiliation wicri:level="1"><nlm:aff id="A109">Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A110">Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P." last="Morris">Andrew P. Morris</name><affiliation wicri:level="1"><nlm:aff id="A70">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Gl Ser, Sven" sort="Gl Ser, Sven" uniqKey="Gl Ser S" first="Sven" last="Gl Ser">Sven Gl Ser</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Twins Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Burkart, Kristin M" sort="Burkart, Kristin M" uniqKey="Burkart K" first="Kristin M." last="Burkart">Kristin M. Burkart</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Beilby, John" sort="Beilby, John" uniqKey="Beilby J" first="John" last="Beilby">John Beilby</name><affiliation wicri:level="1"><nlm:aff id="A53">PathWest Laboratory Medicine WA, Nedlands, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>PathWest Laboratory Medicine WA, Nedlands</wicri:regionArea></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation wicri:level="1"><nlm:aff id="A111">Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>Iceland Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Hancock, Dana B" sort="Hancock, Dana B" uniqKey="Hancock D" first="Dana B." last="Hancock">Dana B. Hancock</name><affiliation wicri:level="1"><nlm:aff id="A112">Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC</wicri:regionArea></affiliation></author><author><name sortKey="Williams, O Dale" sort="Williams, O Dale" uniqKey="Williams O" first="O. Dale" last="Williams">O. Dale Williams</name><affiliation wicri:level="1"><nlm:aff id="A113">Florida International University, Miami, FL, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Florida International University, Miami, FL</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="A114">Department of Public Health, Medical School, University of Split, Split, Croatia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Croatie</country><wicri:regionArea>Department of Public Health, Medical School, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation wicri:level="1"><nlm:aff id="A115">Department of Medical Biology, Medical School, University of Split, Split, Croatia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Croatie</country><wicri:regionArea>Department of Medical Biology, Medical School, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation wicri:level="1"><nlm:aff id="A114">Department of Public Health, Medical School, University of Split, Split, Croatia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Croatie</country><wicri:regionArea>Department of Public Health, Medical School, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Petrini, Marcy F" sort="Petrini, Marcy F" uniqKey="Petrini M" first="Marcy F." last="Petrini">Marcy F. Petrini</name><affiliation wicri:level="1"><nlm:aff id="A116">Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Wjst, Matthias" sort="Wjst, Matthias" uniqKey="Wjst M" first="Matthias" last="Wjst">Matthias Wjst</name><affiliation wicri:level="1"><nlm:aff id="A117">Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), München, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), München</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Woo Jin" sort="Kim, Woo Jin" uniqKey="Kim W" first="Woo Jin" last="Kim">Woo Jin Kim</name><affiliation wicri:level="1"><nlm:aff id="A118">Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A119">Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon</wicri:regionArea></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation wicri:level="1"><nlm:aff id="A63">Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name><affiliation wicri:level="1"><nlm:aff id="A76">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Blair H" sort="Smith, Blair H" uniqKey="Smith B" first="Blair H." last="Smith">Blair H. Smith</name><affiliation wicri:level="1"><nlm:aff id="A75">Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea></affiliation></author><author><name sortKey="Viljanen, Anne" sort="Viljanen, Anne" uniqKey="Viljanen A" first="Anne" last="Viljanen">Anne Viljanen</name><affiliation wicri:level="1"><nlm:aff id="A97">Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä</wicri:regionArea></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation wicri:level="1"><nlm:aff id="A26">The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>The National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R." last="Attia">John R. Attia</name><affiliation wicri:level="1"><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Faculty of Health, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Sayers, Ian" sort="Sayers, Ian" uniqKey="Sayers I" first="Ian" last="Sayers">Ian Sayers</name><affiliation wicri:level="1"><nlm:aff id="A120">Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Hampel, Regina" sort="Hampel, Regina" uniqKey="Hampel R" first="Regina" last="Hampel">Regina Hampel</name><affiliation wicri:level="1"><nlm:aff id="A121">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="1"><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Boezen, H Marike" sort="Boezen, H Marike" uniqKey="Boezen H" first="H. Marike" last="Boezen">H. Marike Boezen</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Newman, Anne" sort="Newman, Anne" uniqKey="Newman A" first="Anne" last="Newman">Anne Newman</name><affiliation wicri:level="1"><nlm:aff id="A122">Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A123">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A124">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A125">Unit of Primary Care, Oulu University Hospital, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Unit of Primary Care, Oulu University Hospital, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A126">Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="1"><nlm:aff id="A69">Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Stricker, Bruno H" sort="Stricker, Bruno H" uniqKey="Stricker B" first="Bruno H." last="Stricker">Bruno H. Stricker</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Health Care Inspectorate, The Hague, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Health Care Inspectorate, The Hague</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="A127">Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Twins Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Melen, Erik" sort="Melen, Erik" uniqKey="Melen E" first="Erik" last="Melén">Erik Melén</name><affiliation wicri:level="1"><nlm:aff id="A128">Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J." last="Peters">Marjolein J. Peters</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A." last="Lange">Leslie A. Lange</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Genetics, University of North Carolina, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Barr, R Graham" sort="Barr, R Graham" uniqKey="Barr R" first="R. Graham" last="Barr">R. Graham Barr</name><affiliation wicri:level="1"><nlm:aff id="A108">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Bracke, Ken R" sort="Bracke, Ken R" uniqKey="Bracke K" first="Ken R." last="Bracke">Ken R. Bracke</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Department of Respiratory Medicine, Ghent University Hospital, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Verhamme, Fien M" sort="Verhamme, Fien M" uniqKey="Verhamme F" first="Fien M." last="Verhamme">Fien M. Verhamme</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Department of Respiratory Medicine, Ghent University Hospital, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Sung, Joohon" sort="Sung, Joohon" uniqKey="Sung J" first="Joohon" last="Sung">Joohon Sung</name><affiliation wicri:level="1"><nlm:aff id="A16">Institute of Health and Environment, Seoul National University, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Institute of Health and Environment, Seoul National University, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A129">Complex Disease & Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Complex Disease & Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Hiemstra, Pieter S" sort="Hiemstra, Pieter S" uniqKey="Hiemstra P" first="Pieter S." last="Hiemstra">Pieter S. Hiemstra</name><affiliation wicri:level="1"><nlm:aff id="A130">Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pulmonology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Cassano, Patricia A" sort="Cassano, Patricia A" uniqKey="Cassano P" first="Patricia A." last="Cassano">Patricia A. Cassano</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Nutritional Sciences, Cornell University, Ithaca, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A131">Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Sood, Akshay" sort="Sood, Akshay" uniqKey="Sood A" first="Akshay" last="Sood">Akshay Sood</name><affiliation wicri:level="1"><nlm:aff id="A132">University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Dupuis, Josee" sort="Dupuis, Josee" uniqKey="Dupuis J" first="Josée" last="Dupuis">Josée Dupuis</name><affiliation wicri:level="1"><nlm:aff id="A77">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A99">The NHLBI's Framingham Heart Study, Framingham, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>The NHLBI's Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Ian P" sort="Hall, Ian P" uniqKey="Hall I" first="Ian P." last="Hall">Ian P. Hall</name><affiliation wicri:level="1"><nlm:aff id="A120">Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Brusselle, Guy G" sort="Brusselle, Guy G" uniqKey="Brusselle G" first="Guy G." last="Brusselle">Guy G. Brusselle</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Department of Respiratory Medicine, Ghent University Hospital, Ghent</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A133">Department of Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Respiratory Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D." last="Tobin">Martin D. Tobin</name><affiliation wicri:level="1"><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea></affiliation></author><author><name sortKey="London, Stephanie J" sort="London, Stephanie J" uniqKey="London S" first="Stephanie J." last="London">Stephanie J. London</name><affiliation wicri:level="1"><nlm:aff id="A86">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24929828</idno><idno type="pmc">4140093</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140093</idno><idno type="RBID">PMC:4140093</idno><idno type="doi">10.1038/ng.3011</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002146</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002146</idno><idno type="wicri:Area/Pmc/Curation">001F98</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001F98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analysis identifies six new loci associated with forced vital capacity</title><author><name sortKey="Loth, Daan W" sort="Loth, Daan W" uniqKey="Loth D" first="Daan W." last="Loth">Daan W. Loth</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Health Care Inspectorate, The Hague, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Health Care Inspectorate, The Hague</wicri:regionArea></affiliation></author><author><name sortKey="Artigas, Maria Soler" sort="Artigas, Maria Soler" uniqKey="Artigas M" first="María Soler" last="Artigas">María Soler Artigas</name><affiliation wicri:level="1"><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea></affiliation></author><author><name sortKey="Gharib, Sina A" sort="Gharib, Sina A" uniqKey="Gharib S" first="Sina A." last="Gharib">Sina A. Gharib</name><affiliation wicri:level="1"><nlm:aff id="A5">Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Wain, Louise V" sort="Wain, Louise V" uniqKey="Wain L" first="Louise V." last="Wain">Louise V. Wain</name><affiliation wicri:level="1"><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea></affiliation></author><author><name sortKey="Franceschini, Nora" sort="Franceschini, Nora" uniqKey="Franceschini N" first="Nora" last="Franceschini">Nora Franceschini</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Koch, Beate" sort="Koch, Beate" uniqKey="Koch B" first="Beate" last="Koch">Beate Koch</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Pottinger, Tess" sort="Pottinger, Tess" uniqKey="Pottinger T" first="Tess" last="Pottinger">Tess Pottinger</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation wicri:level="1"><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>Iceland Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Duan, Qing" sort="Duan, Qing" uniqKey="Duan Q" first="Qing" last="Duan">Qing Duan</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Genetics, University of North Carolina, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Oldmeadow, Chris" sort="Oldmeadow, Chris" uniqKey="Oldmeadow C" first="Chris" last="Oldmeadow">Chris Oldmeadow</name><affiliation wicri:level="1"><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Faculty of Health, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mi Kyeong" sort="Lee, Mi Kyeong" uniqKey="Lee M" first="Mi Kyeong" last="Lee">Mi Kyeong Lee</name><affiliation wicri:level="1"><nlm:aff id="A16">Institute of Health and Environment, Seoul National University, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Institute of Health and Environment, Seoul National University, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name><affiliation wicri:level="1"><nlm:aff id="A17">Division of Population Health Sciences and Education, St George's, University of London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Division of Population Health Sciences and Education, St George's, University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L." last="James">Alan L. James</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Nedlands, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Nedlands</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>School of Medicine and Pharmacology, The University of Western Australia, Perth</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A20">Busselton Population Medical Research Institute, Busselton, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Busselton Population Medical Research Institute, Busselton</wicri:regionArea></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation wicri:level="1"><nlm:aff id="A22">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="1"><nlm:aff id="A25">Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>The National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xin Qun" sort="Wang, Xin Qun" uniqKey="Wang X" first="Xin-Qun" last="Wang">Xin-Qun Wang</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Public Health Sciences, University of Virginia, Charlottesville, VA</wicri:regionArea></affiliation></author><author><name sortKey="Trochet, Holly" sort="Trochet, Holly" uniqKey="Trochet H" first="Holly" last="Trochet">Holly Trochet</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere</wicri:regionArea></affiliation></author><author><name sortKey="Flexeder, Claudia" sort="Flexeder, Claudia" uniqKey="Flexeder C" first="Claudia" last="Flexeder">Claudia Flexeder</name><affiliation wicri:level="1"><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="1"><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="De Jong, Kim" sort="De Jong, Kim" uniqKey="De Jong K" first="Kim" last="De Jong">Kim De Jong</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Thyagarajan, Bharat" sort="Thyagarajan, Bharat" uniqKey="Thyagarajan B" first="Bharat" last="Thyagarajan">Bharat Thyagarajan</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Alves, Alexessander Couto" sort="Alves, Alexessander Couto" uniqKey="Alves A" first="Alexessander Couto" last="Alves">Alexessander Couto Alves</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Omenaas, Ernst" sort="Omenaas, Ernst" uniqKey="Omenaas E" first="Ernst" last="Omenaas">Ernst Omenaas</name><affiliation wicri:level="1"><nlm:aff id="A39">Haukeland University Hospital, Bergen, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Haukeland University Hospital, Bergen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">Department Clinical Sciences, University of Bergen, Bergen, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department Clinical Sciences, University of Bergen, Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Vi Uela, Ana" sort="Vi Uela, Ana" uniqKey="Vi Uela A" first="Ana" last="Vi Uela">Ana Vi Uela</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Twins Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Loehr, Laura R" sort="Loehr, Laura R" uniqKey="Loehr L" first="Laura R." last="Loehr">Laura R. Loehr</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A46">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation wicri:level="1"><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name><affiliation wicri:level="1"><nlm:aff id="A48">Precision Medicine, Pfizer Global Research and Development, Cambridge, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Precision Medicine, Pfizer Global Research and Development, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Tang, Wenbo" sort="Tang, Wenbo" uniqKey="Tang W" first="Wenbo" last="Tang">Wenbo Tang</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Nutritional Sciences, Cornell University, Ithaca, NY</wicri:regionArea></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation wicri:level="1"><nlm:aff id="A50">Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia</wicri:regionArea></affiliation></author><author><name sortKey="Lahousse, Lies" sort="Lahousse, Lies" uniqKey="Lahousse L" first="Lies" last="Lahousse">Lies Lahousse</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Department of Respiratory Medicine, Ghent University Hospital, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E." last="North">Kari E. North</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name><affiliation wicri:level="1"><nlm:aff id="A17">Division of Population Health Sciences and Education, St George's, University of London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Division of Population Health Sciences and Education, St George's, University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation wicri:level="1"><nlm:aff id="A53">PathWest Laboratory Medicine WA, Nedlands, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>PathWest Laboratory Medicine WA, Nedlands</wicri:regionArea></affiliation></author><author><name sortKey="Gu, Xiangjun" sort="Gu, Xiangjun" uniqKey="Gu X" first="Xiangjun" last="Gu">Xiangjun Gu</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A46">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name><affiliation wicri:level="1"><nlm:aff id="A54">Department of Statistics, University of Auckland, Auckland, New Zealand.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Nouvelle-Zélande</country><wicri:regionArea>Department of Statistics, University of Auckland, Auckland</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Hastie, Nicholas D" sort="Hastie, Nicholas D" uniqKey="Hastie N" first="Nicholas D." last="Hastie">Nicholas D. Hastie</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Susan" sort="Campbell, Susan" uniqKey="Campbell S" first="Susan" last="Campbell">Susan Campbell</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Kumar, Rajesh" sort="Kumar, Rajesh" uniqKey="Kumar R" first="Rajesh" last="Kumar">Rajesh Kumar</name><affiliation wicri:level="1"><nlm:aff id="A55">Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name><affiliation wicri:level="1"><nlm:aff id="A56">Centre Hospitallier Universitaire de Grenoble, Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Centre Hospitallier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">INSERM U823, Institut Albert Bonniot, Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>INSERM U823, Institut Albert Bonniot, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Université Joseph Fourier, Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A." last="Scott">Robert A. Scott</name><affiliation wicri:level="1"><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H." last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A59">Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A60">Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="1"><nlm:aff id="A62">Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Faculty of Health, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Schulz, Holger" sort="Schulz, Holger" uniqKey="Schulz H" first="Holger" last="Schulz">Holger Schulz</name><affiliation wicri:level="1"><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation wicri:level="1"><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation wicri:level="1"><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A63">Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A64">MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Institute of Genetics and Molecular Medicine, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Vonk, Judith M" sort="Vonk, Judith M" uniqKey="Vonk J" first="Judith M." last="Vonk">Judith M. Vonk</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Wojczynski, Mary" sort="Wojczynski, Mary" uniqKey="Wojczynski M" first="Mary" last="Wojczynski">Mary Wojczynski</name><affiliation wicri:level="1"><nlm:aff id="A65">Department of Statistical Genomics, Washington University, St. Louis, MO, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Statistical Genomics, Washington University, St. Louis, MO</wicri:regionArea></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="A66">National Institute for Health and Welfare, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A68">Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Uppsala Clinical Research Center, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A70">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="A73">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Twins Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>Iceland Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C." last="Morrison">Alanna C. Morrison</name><affiliation wicri:level="1"><nlm:aff id="A74">School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>School of Public Health, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="1"><nlm:aff id="A75">Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A76">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Wei" sort="Gao, Wei" uniqKey="Gao W" first="Wei" last="Gao">Wei Gao</name><affiliation wicri:level="1"><nlm:aff id="A77">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name><affiliation wicri:level="1"><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A78">University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="White, Wendy B" sort="White, Wendy B" uniqKey="White W" first="Wendy B." last="White">Wendy B. White</name><affiliation wicri:level="1"><nlm:aff id="A79">Tougaloo College, Jackson, MS, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Tougaloo College, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name><affiliation wicri:level="1"><nlm:aff id="A50">Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>Iceland Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Couper, David" sort="Couper, David" uniqKey="Couper D" first="David" last="Couper">David Couper</name><affiliation wicri:level="1"><nlm:aff id="A80">Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Lewis J" sort="Smith, Lewis J" uniqKey="Smith L" first="Lewis J." last="Smith">Lewis J. Smith</name><affiliation wicri:level="1"><nlm:aff id="A55">Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A81">Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A82">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation wicri:level="1"><nlm:aff id="A83">Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Burchard, Esteban G" sort="Burchard, Esteban G" uniqKey="Burchard E" first="Esteban G." last="Burchard">Esteban G. Burchard</name><affiliation wicri:level="1"><nlm:aff id="A84">Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A85">Department of Medicine, University of California, San Francisco, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, University of California, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name><affiliation wicri:level="1"><nlm:aff id="A44">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Joubert, Bonnie R" sort="Joubert, Bonnie R" uniqKey="Joubert B" first="Bonnie R." last="Joubert">Bonnie R. Joubert</name><affiliation wicri:level="1"><nlm:aff id="A86">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC</wicri:regionArea></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation wicri:level="1"><nlm:aff id="A87">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Musk, A Bill" sort="Musk, A Bill" uniqKey="Musk A" first="A. Bill" last="Musk">A. Bill Musk</name><affiliation wicri:level="1"><nlm:aff id="A88">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands</wicri:regionArea></affiliation></author><author><name sortKey="Hansel, Nadia" sort="Hansel, Nadia" uniqKey="Hansel N" first="Nadia" last="Hansel">Nadia Hansel</name><affiliation wicri:level="1"><nlm:aff id="A89">Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, Johns Hopkins University, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Heckbert, Susan R" sort="Heckbert, Susan R" uniqKey="Heckbert S" first="Susan R." last="Heckbert">Susan R. Heckbert</name><affiliation wicri:level="1"><nlm:aff id="A47">Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A81">Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A82">Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation wicri:level="1"><nlm:aff id="A90">Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Irlande (pays)</country><wicri:regionArea>Department of Public Health and Primary Care, Trinity College Dublin, Dublin</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A91">Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Croatie</country><wicri:regionArea>Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Van Meurs, Joyce B J" sort="Van Meurs, Joyce B J" uniqKey="Van Meurs J" first="Joyce B. J." last="Van Meurs">Joyce B. J. Van Meurs</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="1"><nlm:aff id="A92">Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Oh, Yeon Mok" sort="Oh, Yeon Mok" uniqKey="Oh Y" first="Yeon-Mok" last="Oh">Yeon-Mok Oh</name><affiliation wicri:level="1"><nlm:aff id="A93">Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A94">Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="1"><nlm:aff id="A95">Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, Brigham Women's Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Jarvis, Deborah" sort="Jarvis, Deborah" uniqKey="Jarvis D" first="Deborah" last="Jarvis">Deborah Jarvis</name><affiliation wicri:level="1"><nlm:aff id="A22">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A96">MRC-PHE Centre for Environment & Health, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC-PHE Centre for Environment & Health, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="1"><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Rantanen, Taina" sort="Rantanen, Taina" uniqKey="Rantanen T" first="Taina" last="Rantanen">Taina Rantanen</name><affiliation wicri:level="1"><nlm:aff id="A97">Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä</wicri:regionArea></affiliation></author><author><name sortKey="O Onnor, George T" sort="O Onnor, George T" uniqKey="O Onnor G" first="George T." last="O Onnor">George T. O Onnor</name><affiliation wicri:level="1"><nlm:aff id="A98">Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Pulmonary Center, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A99">The NHLBI's Framingham Heart Study, Framingham, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>The NHLBI's Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation wicri:level="1"><nlm:aff id="A27">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A100">Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Faculty of Health, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Karrasch, Stefan" sort="Karrasch, Stefan" uniqKey="Karrasch S" first="Stefan" last="Karrasch">Stefan Karrasch</name><affiliation wicri:level="1"><nlm:aff id="A30">Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A101">Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A102">Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation wicri:level="1"><nlm:aff id="A103">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Gaddis, Nathan C" sort="Gaddis, Nathan C" uniqKey="Gaddis N" first="Nathan C." last="Gaddis">Nathan C. Gaddis</name><affiliation wicri:level="1"><nlm:aff id="A104">Research Computing Division, Research Triangle Institute International, Research Triangle Park, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Research Computing Division, Research Triangle Institute International, Research Triangle Park, NC</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A105">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation wicri:level="1"><nlm:aff id="A106">Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Minster, Ryan L" sort="Minster, Ryan L" uniqKey="Minster R" first="Ryan L." last="Minster">Ryan L. Minster</name><affiliation wicri:level="1"><nlm:aff id="A107">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Lederer, David J" sort="Lederer, David J" uniqKey="Lederer D" first="David J." last="Lederer">David J. Lederer</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A108">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Pekkanen, Juha" sort="Pekkanen, Juha" uniqKey="Pekkanen J" first="Juha" last="Pekkanen">Juha Pekkanen</name><affiliation wicri:level="1"><nlm:aff id="A109">Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A110">Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Morris, Andrew P" sort="Morris, Andrew P" uniqKey="Morris A" first="Andrew P." last="Morris">Andrew P. Morris</name><affiliation wicri:level="1"><nlm:aff id="A70">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Gl Ser, Sven" sort="Gl Ser, Sven" uniqKey="Gl Ser S" first="Sven" last="Gl Ser">Sven Gl Ser</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Twins Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Burkart, Kristin M" sort="Burkart, Kristin M" uniqKey="Burkart K" first="Kristin M." last="Burkart">Kristin M. Burkart</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Beilby, John" sort="Beilby, John" uniqKey="Beilby J" first="John" last="Beilby">John Beilby</name><affiliation wicri:level="1"><nlm:aff id="A53">PathWest Laboratory Medicine WA, Nedlands, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>PathWest Laboratory Medicine WA, Nedlands</wicri:regionArea></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation wicri:level="1"><nlm:aff id="A111">Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A11">Iceland Heart Association, Kopavogur, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>Iceland Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">University of Iceland, Reykjavik, Iceland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Hancock, Dana B" sort="Hancock, Dana B" uniqKey="Hancock D" first="Dana B." last="Hancock">Dana B. Hancock</name><affiliation wicri:level="1"><nlm:aff id="A112">Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC</wicri:regionArea></affiliation></author><author><name sortKey="Williams, O Dale" sort="Williams, O Dale" uniqKey="Williams O" first="O. Dale" last="Williams">O. Dale Williams</name><affiliation wicri:level="1"><nlm:aff id="A113">Florida International University, Miami, FL, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Florida International University, Miami, FL</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="A114">Department of Public Health, Medical School, University of Split, Split, Croatia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Croatie</country><wicri:regionArea>Department of Public Health, Medical School, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation wicri:level="1"><nlm:aff id="A115">Department of Medical Biology, Medical School, University of Split, Split, Croatia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Croatie</country><wicri:regionArea>Department of Medical Biology, Medical School, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation wicri:level="1"><nlm:aff id="A114">Department of Public Health, Medical School, University of Split, Split, Croatia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Croatie</country><wicri:regionArea>Department of Public Health, Medical School, University of Split, Split</wicri:regionArea></affiliation></author><author><name sortKey="Petrini, Marcy F" sort="Petrini, Marcy F" uniqKey="Petrini M" first="Marcy F." last="Petrini">Marcy F. Petrini</name><affiliation wicri:level="1"><nlm:aff id="A116">Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Wjst, Matthias" sort="Wjst, Matthias" uniqKey="Wjst M" first="Matthias" last="Wjst">Matthias Wjst</name><affiliation wicri:level="1"><nlm:aff id="A117">Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), München, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), München</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Woo Jin" sort="Kim, Woo Jin" uniqKey="Kim W" first="Woo Jin" last="Kim">Woo Jin Kim</name><affiliation wicri:level="1"><nlm:aff id="A118">Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A119">Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon</wicri:regionArea></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation wicri:level="1"><nlm:aff id="A63">Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name><affiliation wicri:level="1"><nlm:aff id="A76">Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Blair H" sort="Smith, Blair H" uniqKey="Smith B" first="Blair H." last="Smith">Blair H. Smith</name><affiliation wicri:level="1"><nlm:aff id="A75">Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea></affiliation></author><author><name sortKey="Viljanen, Anne" sort="Viljanen, Anne" uniqKey="Viljanen A" first="Anne" last="Viljanen">Anne Viljanen</name><affiliation wicri:level="1"><nlm:aff id="A97">Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä</wicri:regionArea></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation wicri:level="1"><nlm:aff id="A26">The National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>The National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R." last="Attia">John R. Attia</name><affiliation wicri:level="1"><nlm:aff id="A14">Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Faculty of Health, University of Newcastle, Newcastle, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Sayers, Ian" sort="Sayers, Ian" uniqKey="Sayers I" first="Ian" last="Sayers">Ian Sayers</name><affiliation wicri:level="1"><nlm:aff id="A120">Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Hampel, Regina" sort="Hampel, Regina" uniqKey="Hampel R" first="Regina" last="Hampel">Regina Hampel</name><affiliation wicri:level="1"><nlm:aff id="A121">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="A31">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="1"><nlm:aff id="A32">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Department of Psychology, The University of Edinburgh, Edinburgh, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Boezen, H Marike" sort="Boezen, H Marike" uniqKey="Boezen H" first="H. Marike" last="Boezen">H. Marike Boezen</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Newman, Anne" sort="Newman, Anne" uniqKey="Newman A" first="Anne" last="Newman">Anne Newman</name><affiliation wicri:level="1"><nlm:aff id="A122">Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A123">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A124">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A125">Unit of Primary Care, Oulu University Hospital, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Unit of Primary Care, Oulu University Hospital, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A126">Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="1"><nlm:aff id="A69">Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Stricker, Bruno H" sort="Stricker, Bruno H" uniqKey="Stricker B" first="Bruno H." last="Stricker">Bruno H. Stricker</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Netherlands Health Care Inspectorate, The Hague, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Health Care Inspectorate, The Hague</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="A127">Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Twins Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Melen, Erik" sort="Melen, Erik" uniqKey="Melen E" first="Erik" last="Melén">Erik Melén</name><affiliation wicri:level="1"><nlm:aff id="A128">Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm, Sweden.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Marjolein J" sort="Peters, Marjolein J" uniqKey="Peters M" first="Marjolein J." last="Peters">Marjolein J. Peters</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A72">Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A." last="Lange">Leslie A. Lange</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Genetics, University of North Carolina, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Barr, R Graham" sort="Barr, R Graham" uniqKey="Barr R" first="R. Graham" last="Barr">R. Graham Barr</name><affiliation wicri:level="1"><nlm:aff id="A108">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Bracke, Ken R" sort="Bracke, Ken R" uniqKey="Bracke K" first="Ken R." last="Bracke">Ken R. Bracke</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Department of Respiratory Medicine, Ghent University Hospital, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Verhamme, Fien M" sort="Verhamme, Fien M" uniqKey="Verhamme F" first="Fien M." last="Verhamme">Fien M. Verhamme</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Department of Respiratory Medicine, Ghent University Hospital, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Sung, Joohon" sort="Sung, Joohon" uniqKey="Sung J" first="Joohon" last="Sung">Joohon Sung</name><affiliation wicri:level="1"><nlm:aff id="A16">Institute of Health and Environment, Seoul National University, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Institute of Health and Environment, Seoul National University, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A129">Complex Disease & Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul, South Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Complex Disease & Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Hiemstra, Pieter S" sort="Hiemstra, Pieter S" uniqKey="Hiemstra P" first="Pieter S." last="Hiemstra">Pieter S. Hiemstra</name><affiliation wicri:level="1"><nlm:aff id="A130">Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pulmonology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Cassano, Patricia A" sort="Cassano, Patricia A" uniqKey="Cassano P" first="Patricia A." last="Cassano">Patricia A. Cassano</name><affiliation wicri:level="1"><nlm:aff id="A49">Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Nutritional Sciences, Cornell University, Ithaca, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A131">Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Sood, Akshay" sort="Sood, Akshay" uniqKey="Sood A" first="Akshay" last="Sood">Akshay Sood</name><affiliation wicri:level="1"><nlm:aff id="A132">University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="A21">MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland</wicri:regionArea></affiliation></author><author><name sortKey="Dupuis, Josee" sort="Dupuis, Josee" uniqKey="Dupuis J" first="Josée" last="Dupuis">Josée Dupuis</name><affiliation wicri:level="1"><nlm:aff id="A77">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A99">The NHLBI's Framingham Heart Study, Framingham, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>The NHLBI's Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Ian P" sort="Hall, Ian P" uniqKey="Hall I" first="Ian P." last="Hall">Ian P. Hall</name><affiliation wicri:level="1"><nlm:aff id="A120">Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Brusselle, Guy G" sort="Brusselle, Guy G" uniqKey="Brusselle G" first="Guy G." last="Brusselle">Guy G. Brusselle</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Department of Respiratory Medicine, Ghent University Hospital, Ghent</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A133">Department of Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Respiratory Medicine, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D." last="Tobin">Martin D. Tobin</name><affiliation wicri:level="1"><nlm:aff id="A3">Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester</wicri:regionArea></affiliation></author><author><name sortKey="London, Stephanie J" sort="London, Stephanie J" uniqKey="London S" first="Stephanie J." last="London">Stephanie J. London</name><affiliation wicri:level="1"><nlm:aff id="A86">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (<italic>P</italic> < 5 × 10<sup>−8</sup>) with FVC in or near <italic>EFEMP1, BMP6, MIR-129-2/HSD17B12, PRDM11, WWOX</italic>, and <italic>KCNJ2</italic>. Two (<italic>GSTCD</italic> and <italic>PTCH1</italic>) loci previously associated with spirometric measures were related to FVC. Newly implicated regions were followed-up in samples of African American, Korean, Chinese, and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and pathogenesis of restrictive lung disease.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24929828</article-id><article-id pub-id-type="pmc">4140093</article-id><article-id pub-id-type="doi">10.1038/ng.3011</article-id><article-id pub-id-type="manuscript">NIHMS608728</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association analysis identifies six new loci associated with forced vital capacity</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Loth</surname><given-names>Daan W.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib 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rid="A108">108</xref></contrib><contrib contrib-type="author"><name><surname>Pekkanen</surname><given-names>Juha</given-names></name><xref ref-type="aff" rid="A109">109</xref><xref ref-type="aff" rid="A110">110</xref></contrib><contrib contrib-type="author"><name><surname>Gyllensten</surname><given-names>Ulf</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Harry</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>Andrew P.</given-names></name><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Gläser</surname><given-names>Sven</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Hammond</surname><given-names>Christopher J.</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Burkart</surname><given-names>Kristin M.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Beilby</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Kritchevsky</surname><given-names>Stephen B.</given-names></name><xref ref-type="aff" rid="A111">111</xref></contrib><contrib contrib-type="author"><name><surname>Gudnason</surname><given-names>Vilmundur</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Hancock</surname><given-names>Dana B.</given-names></name><xref ref-type="aff" rid="A112">112</xref></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>O. Dale</given-names></name><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Polasek</surname><given-names>Ozren</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Zemunik</surname><given-names>Tatijana</given-names></name><xref ref-type="aff" rid="A115">115</xref></contrib><contrib contrib-type="author"><name><surname>Kolcic</surname><given-names>Ivana</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Petrini</surname><given-names>Marcy F.</given-names></name><xref ref-type="aff" rid="A116">116</xref></contrib><contrib contrib-type="author"><name><surname>Wjst</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="A117">117</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Woo Jin</given-names></name><xref ref-type="aff" rid="A118">118</xref><xref ref-type="aff" rid="A119">119</xref></contrib><contrib contrib-type="author"><name><surname>Porteous</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Scotland</surname><given-names>Generation</given-names></name><xref ref-type="aff" rid="A76">76</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Blair H.</given-names></name><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>Viljanen</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Heliövaara</surname><given-names>Markku</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Attia</surname><given-names>John R.</given-names></name><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Sayers</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A120">120</xref></contrib><contrib contrib-type="author"><name><surname>Hampel</surname><given-names>Regina</given-names></name><xref ref-type="aff" rid="A121">121</xref></contrib><contrib contrib-type="author"><name><surname>Gieger</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Deary</surname><given-names>Ian J.</given-names></name><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Boezen</surname><given-names>H. Marike</given-names></name><xref ref-type="aff" rid="A34">34</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Newman</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A122">122</xref></contrib><contrib contrib-type="author"><name><surname>Jarvelin</surname><given-names>Marjo-Riitta</given-names></name><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A123">123</xref><xref ref-type="aff" rid="A124">124</xref><xref ref-type="aff" rid="A125">125</xref><xref ref-type="aff" rid="A126">126</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>James F.</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Lind</surname><given-names>Lars</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Stricker</surname><given-names>Bruno H.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A71">71</xref><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Teumer</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="A127">127</xref></contrib><contrib contrib-type="author"><name><surname>Spector</surname><given-names>Timothy D.</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Melén</surname><given-names>Erik</given-names></name><xref ref-type="aff" rid="A128">128</xref></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>Marjolein J.</given-names></name><xref ref-type="aff" rid="A71">71</xref><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Lange</surname><given-names>Leslie A.</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Barr</surname><given-names>R. Graham</given-names></name><xref ref-type="aff" rid="A108">108</xref></contrib><contrib contrib-type="author"><name><surname>Bracke</surname><given-names>Ken R.</given-names></name><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Verhamme</surname><given-names>Fien M.</given-names></name><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Sung</surname><given-names>Joohon</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A129">129</xref></contrib><contrib contrib-type="author"><name><surname>Hiemstra</surname><given-names>Pieter S.</given-names></name><xref ref-type="aff" rid="A130">130</xref></contrib><contrib contrib-type="author"><name><surname>Cassano</surname><given-names>Patricia A.</given-names></name><xref ref-type="aff" rid="A49">49</xref><xref ref-type="aff" rid="A131">131</xref></contrib><contrib contrib-type="author"><name><surname>Sood</surname><given-names>Akshay</given-names></name><xref ref-type="aff" rid="A132">132</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Dupuis</surname><given-names>Josée</given-names></name><xref ref-type="aff" rid="A77">77</xref><xref ref-type="aff" rid="A99">99</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Ian P.</given-names></name><xref ref-type="aff" rid="A120">120</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Brusselle</surname><given-names>Guy G.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A52">52</xref><xref ref-type="aff" rid="A133">133</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>Tobin</surname><given-names>Martin D.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib><contrib contrib-type="author"><name><surname>London</surname><given-names>Stephanie J.</given-names></name><xref ref-type="aff" rid="A86">86</xref><xref ref-type="author-notes" rid="FN2">**</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.</aff><aff id="A2"><label>2</label>Netherlands Health Care Inspectorate, The Hague, The Netherlands.</aff><aff id="A3"><label>3</label>Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.</aff><aff id="A4"><label>4</label>National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.</aff><aff id="A5"><label>5</label>Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, WA, USA.</aff><aff id="A6"><label>6</label>Department of Medicine, University of Washington, Seattle, WA, USA.</aff><aff id="A7"><label>7</label>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</aff><aff id="A8"><label>8</label>Carolina Center for Genome Sciences University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</aff><aff id="A9"><label>9</label>Department of Internal Medicine B - Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.</aff><aff id="A10"><label>10</label>Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.</aff><aff id="A11"><label>11</label>Iceland Heart Association, Kopavogur, Iceland.</aff><aff id="A12"><label>12</label>University of Iceland, Reykjavik, Iceland.</aff><aff id="A13"><label>13</label>Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.</aff><aff id="A14"><label>14</label>Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.</aff><aff id="A15"><label>15</label>Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</aff><aff id="A16"><label>16</label>Institute of Health and Environment, Seoul National University, Seoul, South Korea.</aff><aff id="A17"><label>17</label>Division of Population Health Sciences and Education, St George's, University of London, London, UK.</aff><aff id="A18"><label>18</label>Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Nedlands, Australia.</aff><aff id="A19"><label>19</label>School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia.</aff><aff id="A20"><label>20</label>Busselton Population Medical Research Institute, Busselton, Australia.</aff><aff id="A21"><label>21</label>MRC Human Genetics, MRC IGMM, University of Edinburgh, Edinburgh, Scotland, UK.</aff><aff id="A22"><label>22</label>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</aff><aff id="A23"><label>23</label>Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</aff><aff id="A24"><label>24</label>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.</aff><aff id="A25"><label>25</label>Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland.</aff><aff id="A26"><label>26</label>The National Institute for Health and Welfare (THL), Helsinki, Finland.</aff><aff id="A27"><label>27</label>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</aff><aff id="A28"><label>28</label>Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.</aff><aff id="A29"><label>29</label>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</aff><aff id="A30"><label>30</label>Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A31"><label>31</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A32"><label>32</label>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.</aff><aff id="A33"><label>33</label>Department of Psychology, The University of Edinburgh, Edinburgh, UK.</aff><aff id="A34"><label>34</label>University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.</aff><aff id="A35"><label>35</label>GRIAC research institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</aff><aff id="A36"><label>36</label>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.</aff><aff id="A37"><label>37</label>Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</aff><aff id="A38"><label>38</label>Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</aff><aff id="A39"><label>39</label>Haukeland University Hospital, Bergen, Norway.</aff><aff id="A40"><label>40</label>Department Clinical Sciences, University of Bergen, Bergen, Norway.</aff><aff id="A41"><label>41</label>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK.</aff><aff id="A42"><label>42</label>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</aff><aff id="A43"><label>43</label>Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.</aff><aff id="A44"><label>44</label>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</aff><aff id="A45"><label>45</label>Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.</aff><aff id="A46"><label>46</label>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</aff><aff id="A47"><label>47</label>Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.</aff><aff id="A48"><label>48</label>Precision Medicine, Pfizer Global Research and Development, Cambridge, MA, USA.</aff><aff id="A49"><label>49</label>Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.</aff><aff id="A50"><label>50</label>Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.</aff><aff id="A51"><label>51</label>Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA</aff><aff id="A52"><label>52</label>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</aff><aff id="A53"><label>53</label>PathWest Laboratory Medicine WA, Nedlands, Australia.</aff><aff id="A54"><label>54</label>Department of Statistics, University of Auckland, Auckland, New Zealand.</aff><aff id="A55"><label>55</label>Northwestern University Feinberg School of Medicine, Chicago, IL, USA.</aff><aff id="A56"><label>56</label>Centre Hospitallier Universitaire de Grenoble, Grenoble, France.</aff><aff id="A57"><label>57</label>INSERM U823, Institut Albert Bonniot, Grenoble, France.</aff><aff id="A58"><label>58</label>Université Joseph Fourier, Grenoble, France.</aff><aff id="A59"><label>59</label>Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.</aff><aff id="A60"><label>60</label>Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland.</aff><aff id="A61"><label>61</label>Public Health Genomics Unit, Department of Chronic Disease Prevention, The National Institute for Health and Welfare (THL), Helsinki, Finland.</aff><aff id="A62"><label>62</label>Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</aff><aff id="A63"><label>63</label>Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Edinburgh, UK.</aff><aff id="A64"><label>64</label>MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.</aff><aff id="A65"><label>65</label>Department of Statistical Genomics, Washington University, St. Louis, MO, USA.</aff><aff id="A66"><label>66</label>National Institute for Health and Welfare, Oulu, Finland.</aff><aff id="A67"><label>67</label>Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland.</aff><aff id="A68"><label>68</label>Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.</aff><aff id="A69"><label>69</label>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</aff><aff id="A70"><label>70</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</aff><aff id="A71"><label>71</label>Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.</aff><aff id="A72"><label>72</label>Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.</aff><aff id="A73"><label>73</label>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A74"><label>74</label>School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</aff><aff id="A75"><label>75</label>Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.</aff><aff id="A76"><label>76</label>Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</aff><aff id="A77"><label>77</label>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</aff><aff id="A78"><label>78</label>University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands.</aff><aff id="A79"><label>79</label>Tougaloo College, Jackson, MS, USA.</aff><aff id="A80"><label>80</label>Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</aff><aff id="A81"><label>81</label>Department of Epidemiology, University of Washington, Seattle, WA, USA.</aff><aff id="A82"><label>82</label>Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</aff><aff id="A83"><label>83</label>Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.</aff><aff id="A84"><label>84</label>Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA.</aff><aff id="A85"><label>85</label>Department of Medicine, University of California, San Francisco, CA, USA.</aff><aff id="A86"><label>86</label>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.</aff><aff id="A87"><label>87</label>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</aff><aff id="A88"><label>88</label>Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.</aff><aff id="A89"><label>89</label>Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.</aff><aff id="A90"><label>90</label>Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</aff><aff id="A91"><label>91</label>Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.</aff><aff id="A92"><label>92</label>Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland, UK.</aff><aff id="A93"><label>93</label>Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</aff><aff id="A94"><label>94</label>Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</aff><aff id="A95"><label>95</label>Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.</aff><aff id="A96"><label>96</label>MRC-PHE Centre for Environment & Health, Imperial College London, London, UK.</aff><aff id="A97"><label>97</label>Gerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</aff><aff id="A98"><label>98</label>Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.</aff><aff id="A99"><label>99</label>The NHLBI's Framingham Heart Study, Framingham, MA, USA.</aff><aff id="A100"><label>100</label>Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</aff><aff id="A101"><label>101</label>Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany.</aff><aff id="A102"><label>102</label>Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</aff><aff id="A103"><label>103</label>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A104"><label>104</label>Research Computing Division, Research Triangle Institute International, Research Triangle Park, NC, USA.</aff><aff id="A105"><label>105</label>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</aff><aff id="A106"><label>106</label>Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</aff><aff id="A107"><label>107</label>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.</aff><aff id="A108"><label>108</label>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.</aff><aff id="A109"><label>109</label>Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland.</aff><aff id="A110"><label>110</label>Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.</aff><aff id="A111"><label>111</label>Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.</aff><aff id="A112"><label>112</label>Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA.</aff><aff id="A113"><label>113</label>Florida International University, Miami, FL, USA.</aff><aff id="A114"><label>114</label>Department of Public Health, Medical School, University of Split, Split, Croatia.</aff><aff id="A115"><label>115</label>Department of Medical Biology, Medical School, University of Split, Split, Croatia.</aff><aff id="A116"><label>116</label>Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.</aff><aff id="A117"><label>117</label>Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), München, Germany.</aff><aff id="A118"><label>118</label>Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</aff><aff id="A119"><label>119</label>Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.</aff><aff id="A120"><label>120</label>Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.</aff><aff id="A121"><label>121</label>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A122"><label>122</label>Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA.</aff><aff id="A123"><label>123</label>Institute of Health Sciences, University of Oulu, Oulu, Finland.</aff><aff id="A124"><label>124</label>Biocenter Oulu, University of Oulu, Oulu, Finland.</aff><aff id="A125"><label>125</label>Unit of Primary Care, Oulu University Hospital, Oulu, Finland</aff><aff id="A126"><label>126</label>Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.</aff><aff id="A127"><label>127</label>Department for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</aff><aff id="A128"><label>128</label>Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm, Sweden.</aff><aff id="A129"><label>129</label>Complex Disease & Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul, South Korea.</aff><aff id="A130"><label>130</label>Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.</aff><aff id="A131"><label>131</label>Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, USA.</aff><aff id="A132"><label>132</label>University of New Mexico Health Sciences Center School of Medicine, Albuquerque, NM, USA.</aff><aff id="A133"><label>133</label>Department of Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.</aff><author-notes><corresp id="cor1">Correspondence regarding this manuscript should be directed to: Stephanie J. London, <email>london2@niehs.nih.gov</email>, Martin D. Tobin, <email>mt47@le.ac.uk</email></corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">These authors contributed equally to this work</p></fn><fn id="FN2"><label>**</label><p id="P2">These authors jointly directed this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2015</year></pub-date><volume>46</volume><issue>7</issue><fpage>669</fpage><lpage>677</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.3011</pmc-comment>
<abstract><p id="P3">Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (<italic>P</italic> < 5 × 10<sup>−8</sup>) with FVC in or near <italic>EFEMP1, BMP6, MIR-129-2/HSD17B12, PRDM11, WWOX</italic>, and <italic>KCNJ2</italic>. Two (<italic>GSTCD</italic> and <italic>PTCH1</italic>) loci previously associated with spirometric measures were related to FVC. Newly implicated regions were followed-up in samples of African American, Korean, Chinese, and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and pathogenesis of restrictive lung disease.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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