Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Identifieur interne : 001D33 ( Pmc/Curation ); précédent : 001D32; suivant : 001D34Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Auteurs : Olga Kondrashova [Australie] ; Minh Nguyen [États-Unis] ; Kristy Shield-Artin [Australie] ; Anna V. Tinker [Canada] ; Nelson N. H. Teng [États-Unis] ; Maria I. Harrell [États-Unis] ; Michael J. Kuiper [Australie] ; Gwo-Yaw Ho [Australie] ; Holly Barker [Australie] ; Maria Jasin [États-Unis] ; Rohit Prakash [États-Unis] ; Elizabeth M. Kass [États-Unis] ; Meghan R. Sullivan [États-Unis] ; Gregory J. Brunette [États-Unis] ; Kara A. Bernstein [États-Unis] ; Robert L. Coleman [États-Unis] ; Anne Floquet [France] ; Michael Friedlander [Australie] ; Ganessan Kichenadasse [Australie] ; David M. O'Malley [États-Unis] ; Amit Oza [Canada] ; James Sun [États-Unis] ; Liliane Robillard [États-Unis] ; Lara Maloney [États-Unis] ; Heidi Giordano [États-Unis] ; Matthew J. Wakefield [Australie] ; Scott H. Kaufmann [États-Unis] ; Andrew D. Simmons [États-Unis] ; Thomas C. Harding [États-Unis] ; Mitch Raponi [États-Unis] ; Iain A. Mcneish [Royaume-Uni] ; Elizabeth M. Swisher [États-Unis] ; Kevin K. Lin [États-Unis] ; Clare L. Scott [Australie]Source :
- Cancer discovery [ 2159-8274 ] ; 2017.
Abstract
High-grade epithelial ovarian carcinomas containing mutated
Analyses of primary and secondary mutations in
Url:
DOI: 10.1158/2159-8290.CD-17-0419
PubMed: 28588062
PubMed Central: 5612362
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001E77
Links to Exploration step
PMC:5612362Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Secondary Somatic Mutations Restoring <italic>RAD51C</italic> and <italic>RAD51D</italic> Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma</title><author><name sortKey="Kondrashova, Olga" sort="Kondrashova, Olga" uniqKey="Kondrashova O" first="Olga" last="Kondrashova">Olga Kondrashova</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Nguyen, Minh" sort="Nguyen, Minh" uniqKey="Nguyen M" first="Minh" last="Nguyen">Minh Nguyen</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Shield Artin, Kristy" sort="Shield Artin, Kristy" uniqKey="Shield Artin K" first="Kristy" last="Shield-Artin">Kristy Shield-Artin</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Tinker, Anna V" sort="Tinker, Anna V" uniqKey="Tinker A" first="Anna V." last="Tinker">Anna V. Tinker</name><affiliation wicri:level="1"><nlm:aff id="A4">British Columbia Cancer Agency, Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>British Columbia Cancer Agency, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Teng, Nelson N H" sort="Teng, Nelson N H" uniqKey="Teng N" first="Nelson N. H." last="Teng">Nelson N. H. Teng</name><affiliation wicri:level="2"><nlm:aff id="A5">Stanford University, Palo Alto, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford University, Palo Alto</wicri:cityArea></affiliation></author><author><name sortKey="Harrell, Maria I" sort="Harrell, Maria I" uniqKey="Harrell M" first="Maria I." last="Harrell">Maria I. Harrell</name><affiliation wicri:level="2"><nlm:aff id="A6">University of Washington, Seattle, Washington</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Kuiper, Michael J" sort="Kuiper, Michael J" uniqKey="Kuiper M" first="Michael J." last="Kuiper">Michael J. Kuiper</name><affiliation wicri:level="1"><nlm:aff id="A7">Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Gwo Yaw" sort="Ho, Gwo Yaw" uniqKey="Ho G" first="Gwo-Yaw" last="Ho">Gwo-Yaw Ho</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Barker, Holly" sort="Barker, Holly" uniqKey="Barker H" first="Holly" last="Barker">Holly Barker</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Jasin, Maria" sort="Jasin, Maria" uniqKey="Jasin M" first="Maria" last="Jasin">Maria Jasin</name><affiliation wicri:level="2"><nlm:aff id="A9">Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Prakash, Rohit" sort="Prakash, Rohit" uniqKey="Prakash R" first="Rohit" last="Prakash">Rohit Prakash</name><affiliation wicri:level="2"><nlm:aff id="A9">Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Kass, Elizabeth M" sort="Kass, Elizabeth M" uniqKey="Kass E" first="Elizabeth M." last="Kass">Elizabeth M. Kass</name><affiliation wicri:level="2"><nlm:aff id="A9">Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Sullivan, Meghan R" sort="Sullivan, Meghan R" uniqKey="Sullivan M" first="Meghan R." last="Sullivan">Meghan R. Sullivan</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Brunette, Gregory J" sort="Brunette, Gregory J" uniqKey="Brunette G" first="Gregory J." last="Brunette">Gregory J. Brunette</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Bernstein, Kara A" sort="Bernstein, Kara A" uniqKey="Bernstein K" first="Kara A." last="Bernstein">Kara A. Bernstein</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L." last="Coleman">Robert L. Coleman</name><affiliation wicri:level="2"><nlm:aff id="A11">The University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Floquet, Anne" sort="Floquet, Anne" uniqKey="Floquet A" first="Anne" last="Floquet">Anne Floquet</name><affiliation wicri:level="1"><nlm:aff id="A12">Institut Bergonié, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Bergonié, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name><affiliation wicri:level="1"><nlm:aff id="A13">University of New South Wales and Prince of Wales Hospital, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales and Prince of Wales Hospital, Sydney, New South Wales</wicri:regionArea></affiliation></author><author><name sortKey="Kichenadasse, Ganessan" sort="Kichenadasse, Ganessan" uniqKey="Kichenadasse G" first="Ganessan" last="Kichenadasse">Ganessan Kichenadasse</name><affiliation wicri:level="1"><nlm:aff id="A14">Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders University, Adelaide, South Australia</wicri:regionArea></affiliation></author><author><name sortKey="O Malley, David M" sort="O Malley, David M" uniqKey="O Malley D" first="David M." last="O'Malley">David M. O'Malley</name><affiliation wicri:level="2"><nlm:aff id="A15">The Ohio State University, James Cancer Center, Columbus, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>The Ohio State University, James Cancer Center, Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Oza, Amit" sort="Oza, Amit" uniqKey="Oza A" first="Amit" last="Oza">Amit Oza</name><affiliation wicri:level="1"><nlm:aff id="A16">Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Sun, James" sort="Sun, James" uniqKey="Sun J" first="James" last="Sun">James Sun</name><affiliation wicri:level="2"><nlm:aff id="A17">Foundation Medicine, Inc., Cambridge, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Foundation Medicine, Inc., Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Robillard, Liliane" sort="Robillard, Liliane" uniqKey="Robillard L" first="Liliane" last="Robillard">Liliane Robillard</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Maloney, Lara" sort="Maloney, Lara" uniqKey="Maloney L" first="Lara" last="Maloney">Lara Maloney</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Giordano, Heidi" sort="Giordano, Heidi" uniqKey="Giordano H" first="Heidi" last="Giordano">Heidi Giordano</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Wakefield, Matthew J" sort="Wakefield, Matthew J" uniqKey="Wakefield M" first="Matthew J." last="Wakefield">Matthew J. Wakefield</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Kaufmann, Scott H" sort="Kaufmann, Scott H" uniqKey="Kaufmann S" first="Scott H." last="Kaufmann">Scott H. Kaufmann</name><affiliation wicri:level="2"><nlm:aff id="A21">Mayo Clinic Cancer Center, Rochester, Minnesota</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic Cancer Center, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Simmons, Andrew D" sort="Simmons, Andrew D" uniqKey="Simmons A" first="Andrew D." last="Simmons">Andrew D. Simmons</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Harding, Thomas C" sort="Harding, Thomas C" uniqKey="Harding T" first="Thomas C." last="Harding">Thomas C. Harding</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Mcneish, Iain A" sort="Mcneish, Iain A" uniqKey="Mcneish I" first="Iain A." last="Mcneish">Iain A. Mcneish</name><affiliation wicri:level="1"><nlm:aff id="A22">Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Sciences, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Swisher, Elizabeth M" sort="Swisher, Elizabeth M" uniqKey="Swisher E" first="Elizabeth M." last="Swisher">Elizabeth M. Swisher</name><affiliation wicri:level="2"><nlm:aff id="A6">University of Washington, Seattle, Washington</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Lin, Kevin K" sort="Lin, Kevin K" uniqKey="Lin K" first="Kevin K." last="Lin">Kevin K. Lin</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Clare L" sort="Scott, Clare L" uniqKey="Scott C" first="Clare L." last="Scott">Clare L. Scott</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28588062</idno><idno type="pmc">5612362</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612362</idno><idno type="RBID">PMC:5612362</idno><idno type="doi">10.1158/2159-8290.CD-17-0419</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001E77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E77</idno><idno type="wicri:Area/Pmc/Curation">001D33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Secondary Somatic Mutations Restoring <italic>RAD51C</italic> and <italic>RAD51D</italic> Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma</title><author><name sortKey="Kondrashova, Olga" sort="Kondrashova, Olga" uniqKey="Kondrashova O" first="Olga" last="Kondrashova">Olga Kondrashova</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Nguyen, Minh" sort="Nguyen, Minh" uniqKey="Nguyen M" first="Minh" last="Nguyen">Minh Nguyen</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Shield Artin, Kristy" sort="Shield Artin, Kristy" uniqKey="Shield Artin K" first="Kristy" last="Shield-Artin">Kristy Shield-Artin</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Tinker, Anna V" sort="Tinker, Anna V" uniqKey="Tinker A" first="Anna V." last="Tinker">Anna V. Tinker</name><affiliation wicri:level="1"><nlm:aff id="A4">British Columbia Cancer Agency, Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>British Columbia Cancer Agency, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Teng, Nelson N H" sort="Teng, Nelson N H" uniqKey="Teng N" first="Nelson N. H." last="Teng">Nelson N. H. Teng</name><affiliation wicri:level="2"><nlm:aff id="A5">Stanford University, Palo Alto, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford University, Palo Alto</wicri:cityArea></affiliation></author><author><name sortKey="Harrell, Maria I" sort="Harrell, Maria I" uniqKey="Harrell M" first="Maria I." last="Harrell">Maria I. Harrell</name><affiliation wicri:level="2"><nlm:aff id="A6">University of Washington, Seattle, Washington</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Kuiper, Michael J" sort="Kuiper, Michael J" uniqKey="Kuiper M" first="Michael J." last="Kuiper">Michael J. Kuiper</name><affiliation wicri:level="1"><nlm:aff id="A7">Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Gwo Yaw" sort="Ho, Gwo Yaw" uniqKey="Ho G" first="Gwo-Yaw" last="Ho">Gwo-Yaw Ho</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Barker, Holly" sort="Barker, Holly" uniqKey="Barker H" first="Holly" last="Barker">Holly Barker</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Jasin, Maria" sort="Jasin, Maria" uniqKey="Jasin M" first="Maria" last="Jasin">Maria Jasin</name><affiliation wicri:level="2"><nlm:aff id="A9">Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Prakash, Rohit" sort="Prakash, Rohit" uniqKey="Prakash R" first="Rohit" last="Prakash">Rohit Prakash</name><affiliation wicri:level="2"><nlm:aff id="A9">Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Kass, Elizabeth M" sort="Kass, Elizabeth M" uniqKey="Kass E" first="Elizabeth M." last="Kass">Elizabeth M. Kass</name><affiliation wicri:level="2"><nlm:aff id="A9">Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Sullivan, Meghan R" sort="Sullivan, Meghan R" uniqKey="Sullivan M" first="Meghan R." last="Sullivan">Meghan R. Sullivan</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Brunette, Gregory J" sort="Brunette, Gregory J" uniqKey="Brunette G" first="Gregory J." last="Brunette">Gregory J. Brunette</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Bernstein, Kara A" sort="Bernstein, Kara A" uniqKey="Bernstein K" first="Kara A." last="Bernstein">Kara A. Bernstein</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L." last="Coleman">Robert L. Coleman</name><affiliation wicri:level="2"><nlm:aff id="A11">The University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Floquet, Anne" sort="Floquet, Anne" uniqKey="Floquet A" first="Anne" last="Floquet">Anne Floquet</name><affiliation wicri:level="1"><nlm:aff id="A12">Institut Bergonié, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Bergonié, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name><affiliation wicri:level="1"><nlm:aff id="A13">University of New South Wales and Prince of Wales Hospital, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales and Prince of Wales Hospital, Sydney, New South Wales</wicri:regionArea></affiliation></author><author><name sortKey="Kichenadasse, Ganessan" sort="Kichenadasse, Ganessan" uniqKey="Kichenadasse G" first="Ganessan" last="Kichenadasse">Ganessan Kichenadasse</name><affiliation wicri:level="1"><nlm:aff id="A14">Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders University, Adelaide, South Australia</wicri:regionArea></affiliation></author><author><name sortKey="O Malley, David M" sort="O Malley, David M" uniqKey="O Malley D" first="David M." last="O'Malley">David M. O'Malley</name><affiliation wicri:level="2"><nlm:aff id="A15">The Ohio State University, James Cancer Center, Columbus, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>The Ohio State University, James Cancer Center, Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Oza, Amit" sort="Oza, Amit" uniqKey="Oza A" first="Amit" last="Oza">Amit Oza</name><affiliation wicri:level="1"><nlm:aff id="A16">Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Sun, James" sort="Sun, James" uniqKey="Sun J" first="James" last="Sun">James Sun</name><affiliation wicri:level="2"><nlm:aff id="A17">Foundation Medicine, Inc., Cambridge, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Foundation Medicine, Inc., Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Robillard, Liliane" sort="Robillard, Liliane" uniqKey="Robillard L" first="Liliane" last="Robillard">Liliane Robillard</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Maloney, Lara" sort="Maloney, Lara" uniqKey="Maloney L" first="Lara" last="Maloney">Lara Maloney</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Giordano, Heidi" sort="Giordano, Heidi" uniqKey="Giordano H" first="Heidi" last="Giordano">Heidi Giordano</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Wakefield, Matthew J" sort="Wakefield, Matthew J" uniqKey="Wakefield M" first="Matthew J." last="Wakefield">Matthew J. Wakefield</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Kaufmann, Scott H" sort="Kaufmann, Scott H" uniqKey="Kaufmann S" first="Scott H." last="Kaufmann">Scott H. Kaufmann</name><affiliation wicri:level="2"><nlm:aff id="A21">Mayo Clinic Cancer Center, Rochester, Minnesota</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic Cancer Center, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Simmons, Andrew D" sort="Simmons, Andrew D" uniqKey="Simmons A" first="Andrew D." last="Simmons">Andrew D. Simmons</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Harding, Thomas C" sort="Harding, Thomas C" uniqKey="Harding T" first="Thomas C." last="Harding">Thomas C. Harding</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Mcneish, Iain A" sort="Mcneish, Iain A" uniqKey="Mcneish I" first="Iain A." last="Mcneish">Iain A. Mcneish</name><affiliation wicri:level="1"><nlm:aff id="A22">Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Sciences, University of Glasgow, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Swisher, Elizabeth M" sort="Swisher, Elizabeth M" uniqKey="Swisher E" first="Elizabeth M." last="Swisher">Elizabeth M. Swisher</name><affiliation wicri:level="2"><nlm:aff id="A6">University of Washington, Seattle, Washington</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Lin, Kevin K" sort="Lin, Kevin K" uniqKey="Lin K" first="Kevin K." last="Lin">Kevin K. Lin</name><affiliation wicri:level="2"><nlm:aff id="A3">Clovis Oncology, Inc., Boulder, Colorado</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Clovis Oncology, Inc., Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Clare L" sort="Scott, Clare L" uniqKey="Scott C" first="Clare L." last="Scott">Clare L. Scott</name><affiliation wicri:level="1"><nlm:aff id="A1">Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cancer discovery</title><idno type="ISSN">2159-8274</idno><idno type="eISSN">2159-8290</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">High-grade epithelial ovarian carcinomas containing mutated <italic>BRCA1</italic> or <italic>BRCA2</italic> (<italic>BRCA1/2</italic>) homologous recombination (HR) genes are sensitive to platinum-based chemotherapy and PARP inhibitors (PARPi), while restoration of HR function due to secondary mutations in <italic>BRCA1/2</italic> has been recognized as an important resistance mechanism. We sequenced core HR pathway genes in 12 pairs of pretreatment and postprogression tumor biopsy samples collected from patients in ARIEL2 Part 1, a phase II study of the PARPi rucaparib as treatment for platinum-sensitive, relapsed ovarian carcinoma. In 6 of 12 pretreatment biopsies, a truncation mutation in <italic>BRCA1, RAD51C,</italic> or <italic>RAD51D</italic> was identified. In five of six paired postprogression biopsies, one or more secondary mutations restored the open reading frame. Four distinct secondary mutations and spatial heterogeneity were observed for <italic>RAD51C</italic>. <italic>In vitro</italic> complementation assays and a patient-derived xenograft, as well as predictive molecular modeling, confirmed that resistance to rucaparib was associated with secondary mutations.</p><sec id="S1"><title>Significance</title><p id="P2">Analyses of primary and secondary mutations in <italic>RAD51C</italic> and <italic>RAD51D</italic> provide evidence for these primary mutations in conferring PARPi sensitivity and secondary mutations as a mechanism of acquired PARPi resistance. PARPi resistance due to secondary mutations underpins the need for early delivery of PARPi therapy and for combination strategies.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101561693</journal-id><journal-id journal-id-type="pubmed-jr-id">39259</journal-id><journal-id journal-id-type="nlm-ta">Cancer Discov</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Discov</journal-id><journal-title-group><journal-title>Cancer discovery</journal-title></journal-title-group><issn pub-type="ppub">2159-8274</issn><issn pub-type="epub">2159-8290</issn></journal-meta><article-meta><article-id pub-id-type="pmid">28588062</article-id><article-id pub-id-type="pmc">5612362</article-id><article-id pub-id-type="doi">10.1158/2159-8290.CD-17-0419</article-id><article-id pub-id-type="manuscript">NIHMS904258</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Secondary Somatic Mutations Restoring <italic>RAD51C</italic> and <italic>RAD51D</italic> Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kondrashova</surname><given-names>Olga</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nguyen</surname><given-names>Minh</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Shield-Artin</surname><given-names>Kristy</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Tinker</surname><given-names>Anna V.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Teng</surname><given-names>Nelson N.H.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Harrell</surname><given-names>Maria I.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Kuiper</surname><given-names>Michael J.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Gwo-Yaw</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Barker</surname><given-names>Holly</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Jasin</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Prakash</surname><given-names>Rohit</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Kass</surname><given-names>Elizabeth M.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Sullivan</surname><given-names>Meghan R.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Brunette</surname><given-names>Gregory J.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Bernstein</surname><given-names>Kara A.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Coleman</surname><given-names>Robert L.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Floquet</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Friedlander</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Kichenadasse</surname><given-names>Ganessan</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>O'Malley</surname><given-names>David M.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Oza</surname><given-names>Amit</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Sun</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Robillard</surname><given-names>Liliane</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Maloney</surname><given-names>Lara</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><collab>David Bowtell on behalf of the AOCS Study Group</collab><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Giordano</surname><given-names>Heidi</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wakefield</surname><given-names>Matthew J.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Kaufmann</surname><given-names>Scott H.</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Simmons</surname><given-names>Andrew D.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Harding</surname><given-names>Thomas C.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Raponi</surname><given-names>Mitch</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>McNeish</surname><given-names>Iain A.</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Swisher</surname><given-names>Elizabeth M.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Kevin K.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>Clare L.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A8">8</xref></contrib></contrib-group><aff id="A1"><label>1</label>Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia</aff><aff id="A2"><label>2</label>Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A3"><label>3</label>Clovis Oncology, Inc., Boulder, Colorado</aff><aff id="A4"><label>4</label>British Columbia Cancer Agency, Vancouver, British Columbia, Canada</aff><aff id="A5"><label>5</label>Stanford University, Palo Alto, California</aff><aff id="A6"><label>6</label>University of Washington, Seattle, Washington</aff><aff id="A7"><label>7</label>Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A8"><label>8</label>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</aff><aff id="A9"><label>9</label>Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York</aff><aff id="A10"><label>10</label>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</aff><aff id="A11"><label>11</label>The University of Texas MD Anderson Cancer Center, Houston, Texas</aff><aff id="A12"><label>12</label>Institut Bergonié, Bordeaux, France</aff><aff id="A13"><label>13</label>University of New South Wales and Prince of Wales Hospital, Sydney, New South Wales, Australia</aff><aff id="A14"><label>14</label>Flinders University, Adelaide, South Australia, Australia</aff><aff id="A15"><label>15</label>The Ohio State University, James Cancer Center, Columbus, Ohio</aff><aff id="A16"><label>16</label>Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada</aff><aff id="A17"><label>17</label>Foundation Medicine, Inc., Cambridge, Massachusetts</aff><aff id="A18"><label>18</label>Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</aff><aff id="A19"><label>19</label>Centre for Cancer Research, University of Sydney at Westmead Millennium Institute, and Departments of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia</aff><aff id="A20"><label>20</label>QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</aff><aff id="A21"><label>21</label>Mayo Clinic Cancer Center, Rochester, Minnesota</aff><aff id="A22"><label>22</label>Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom</aff><author-notes><corresp id="FN1">Corresponding Author: Clare L. Scott, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia. Phone: 61-3-9345-2498; Fax: 61-3-9347-0852; <email>scottc@wehi.edu.au</email></corresp><fn id="FN2" fn-type="equal"><p>O. Kondrashova, M. Nguyen, K. Shield-Artin, K.K. Lin, and Clare L. Scott contributed equally to this article.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>9</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>06</day><month>6</month><year>2017</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>9</month><year>2017</year></pub-date><volume>7</volume><issue>9</issue><fpage>984</fpage><lpage>998</lpage><pmc-comment>elocation-id from pubmed: 10.1158/2159-8290.CD-17-0419</pmc-comment>
<abstract><p id="P1">High-grade epithelial ovarian carcinomas containing mutated <italic>BRCA1</italic> or <italic>BRCA2</italic> (<italic>BRCA1/2</italic>) homologous recombination (HR) genes are sensitive to platinum-based chemotherapy and PARP inhibitors (PARPi), while restoration of HR function due to secondary mutations in <italic>BRCA1/2</italic> has been recognized as an important resistance mechanism. We sequenced core HR pathway genes in 12 pairs of pretreatment and postprogression tumor biopsy samples collected from patients in ARIEL2 Part 1, a phase II study of the PARPi rucaparib as treatment for platinum-sensitive, relapsed ovarian carcinoma. In 6 of 12 pretreatment biopsies, a truncation mutation in <italic>BRCA1, RAD51C,</italic> or <italic>RAD51D</italic> was identified. In five of six paired postprogression biopsies, one or more secondary mutations restored the open reading frame. Four distinct secondary mutations and spatial heterogeneity were observed for <italic>RAD51C</italic>. <italic>In vitro</italic> complementation assays and a patient-derived xenograft, as well as predictive molecular modeling, confirmed that resistance to rucaparib was associated with secondary mutations.</p><sec id="S1"><title>Significance</title><p id="P2">Analyses of primary and secondary mutations in <italic>RAD51C</italic> and <italic>RAD51D</italic> provide evidence for these primary mutations in conferring PARPi sensitivity and secondary mutations as a mechanism of acquired PARPi resistance. PARPi resistance due to secondary mutations underpins the need for early delivery of PARPi therapy and for combination strategies.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D33 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 001D33 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:5612362
|texte= Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:28588062" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |