The Queensland study of Melanoma: Environmental and Genetic Associations (Q-MEGA). Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures
Identifieur interne : 001C91 ( Pmc/Curation ); précédent : 001C90; suivant : 001C92The Queensland study of Melanoma: Environmental and Genetic Associations (Q-MEGA). Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures
Auteurs : Amanda J. Baxter [Australie] ; Maria Celia Hughes [Australie] ; Marina Kvaskoff [Australie, France] ; Victor Siskind [Australie] ; Sri Shekar [Australie] ; Joanne F. Aitken [Australie] ; Adele C. Green [Australie] ; David L. Duffy [Australie] ; Nicholas K. Hayward [Australie] ; Nicholas G. Martin [Australie] ; David C. Whiteman [Australie]Source :
- Twin research and human genetics : the official journal of the International Society for Twin Studies [ 1832-4274 ] ; 2008.
Abstract
Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia which has the world’s highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland study of Melanoma: Environmental and Genetic Associations, which followed-up four population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. 3,471 participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002–2005. Updated data on environmental and phenotypic risk factors, and 2,777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from six to 17 years later, are also described.
Url:
DOI: 10.1375/twin.11.2.183
PubMed: 18361720
PubMed Central: 3677021
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Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures</title><author><name sortKey="Baxter, Amanda J" sort="Baxter, Amanda J" uniqKey="Baxter A" first="Amanda J." last="Baxter">Amanda J. Baxter</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Hughes, Maria Celia" sort="Hughes, Maria Celia" uniqKey="Hughes M" first="Maria Celia" last="Hughes">Maria Celia Hughes</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Kvaskoff, Marina" sort="Kvaskoff, Marina" uniqKey="Kvaskoff M" first="Marina" last="Kvaskoff">Marina Kvaskoff</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Inserm, (Institut National de la Santé et de la Recherche Médicale), ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, F-94805 France</nlm:aff><country wicri:rule="zip">France</country><wicri:regionArea>Inserm, (Institut National de la Santé et de la Recherche Médicale), ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, F-94805 France</wicri:regionArea></affiliation></author><author><name sortKey="Siskind, Victor" sort="Siskind, Victor" uniqKey="Siskind V" first="Victor" last="Siskind">Victor Siskind</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Shekar, Sri" sort="Shekar, Sri" uniqKey="Shekar S" first="Sri" last="Shekar">Sri Shekar</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name><affiliation wicri:level="1"><nlm:aff id="A3">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C." last="Green">Adele C. Green</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author></analytic><series><title level="j">Twin research and human genetics : the official journal of the International Society for Twin Studies</title><idno type="ISSN">1832-4274</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia which has the world’s highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland study of Melanoma: Environmental and Genetic Associations, which followed-up four population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. 3,471 participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002–2005. Updated data on environmental and phenotypic risk factors, and 2,777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from six to 17 years later, are also described.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101244624</journal-id><journal-id journal-id-type="pubmed-jr-id">32375</journal-id><journal-id journal-id-type="nlm-ta">Twin Res Hum Genet</journal-id><journal-id journal-id-type="iso-abbrev">Twin Res Hum Genet</journal-id><journal-title-group><journal-title>Twin research and human genetics : the official journal of the International Society for Twin Studies</journal-title></journal-title-group><issn pub-type="ppub">1832-4274</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18361720</article-id><article-id pub-id-type="pmc">3677021</article-id><article-id pub-id-type="doi">10.1375/twin.11.2.183</article-id><article-id pub-id-type="manuscript">NIHMS468849</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Queensland study of Melanoma: Environmental and Genetic Associations (Q-MEGA). Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Baxter</surname><given-names>Amanda J.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN2" ref-type="author-notes">+</xref></contrib><contrib contrib-type="author"><name><surname>Hughes</surname><given-names>Maria Celia</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN2" ref-type="author-notes">+</xref></contrib><contrib contrib-type="author"><name><surname>Kvaskoff</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN2" ref-type="author-notes">+</xref></contrib><contrib contrib-type="author"><name><surname>Siskind</surname><given-names>Victor</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN2" ref-type="author-notes">+</xref></contrib><contrib contrib-type="author"><name><surname>Shekar</surname><given-names>Sri</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Aitken</surname><given-names>Joanne F.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Green</surname><given-names>Adele C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Duffy</surname><given-names>David L.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Nicholas K.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Nicholas G.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Whiteman</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Queensland Institute of Medical Research, Brisbane, QLD, Australia</aff><aff id="A2"><label>2</label>Inserm, (Institut National de la Santé et de la Recherche Médicale), ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, F-94805 France</aff><aff id="A3"><label>3</label>Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD, Australia</aff><author-notes><corresp id="FN1">Address for correspondence: Dr David Whiteman, Queensland Institute of Medical Research, Cancer and Population Studies Group, CBCRC/B Floor, PO Royal Brisbane Hospital, Queensland 4029, Australia. <email>David.Whiteman@qimr.edu.au</email></corresp><fn id="FN2" fn-type="equal"><label>+</label><p>These authors contributed equally to this paper and were listed in alphabetical order</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>09</day><month>6</month><year>2013</year></pub-date><volume>11</volume><issue>2</issue><fpage>183</fpage><lpage>196</lpage><abstract><p id="P1">Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia which has the world’s highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland study of Melanoma: Environmental and Genetic Associations, which followed-up four population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. 3,471 participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002–2005. Updated data on environmental and phenotypic risk factors, and 2,777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from six to 17 years later, are also described.</p></abstract><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA088363 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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